GAPDHP23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.12257794
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.12257794
3DNA deamination (GO:0045006)5.09122228
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.88944882
5protein neddylation (GO:0045116)4.80128254
6retinal cone cell development (GO:0046549)4.64444787
7water-soluble vitamin biosynthetic process (GO:0042364)4.50719307
8ATP synthesis coupled proton transport (GO:0015986)4.38945520
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.38945520
10postsynaptic membrane organization (GO:0001941)4.07671394
11chaperone-mediated protein transport (GO:0072321)3.99117755
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.83249535
13ribosomal small subunit assembly (GO:0000028)3.76801793
14protein complex biogenesis (GO:0070271)3.76596160
15synaptic transmission, cholinergic (GO:0007271)3.68146497
16rRNA modification (GO:0000154)3.54791035
17mitochondrial respiratory chain complex assembly (GO:0033108)3.54686980
18behavioral response to nicotine (GO:0035095)3.53346159
19axoneme assembly (GO:0035082)3.52049219
20maturation of SSU-rRNA (GO:0030490)3.48995455
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48181745
22regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.47315098
23intracellular protein transmembrane import (GO:0044743)3.47072336
24rRNA methylation (GO:0031167)3.41517707
25signal peptide processing (GO:0006465)3.38437405
26lysine catabolic process (GO:0006554)3.35668086
27lysine metabolic process (GO:0006553)3.35668086
28mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34091469
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.34091469
30NADH dehydrogenase complex assembly (GO:0010257)3.34091469
31xenobiotic catabolic process (GO:0042178)3.28540490
32nonmotile primary cilium assembly (GO:0035058)3.27554793
33response to folic acid (GO:0051593)3.26369674
34protein K6-linked ubiquitination (GO:0085020)3.25635100
35respiratory electron transport chain (GO:0022904)3.23568964
36proteasome assembly (GO:0043248)3.21448790
37electron transport chain (GO:0022900)3.20928377
38positive regulation of prostaglandin secretion (GO:0032308)3.19301706
39respiratory chain complex IV assembly (GO:0008535)3.16070106
40epithelial cilium movement (GO:0003351)3.14303940
41alkaloid metabolic process (GO:0009820)3.13392026
42neuronal action potential propagation (GO:0019227)3.07046091
43ATP biosynthetic process (GO:0006754)3.02899627
44L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.02870359
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02087810
46thalamus development (GO:0021794)3.01631783
47auditory receptor cell differentiation (GO:0042491)3.00990930
48coenzyme catabolic process (GO:0009109)3.00695374
49regulation of cilium movement (GO:0003352)3.00393187
50cytochrome complex assembly (GO:0017004)2.97550227
51purine nucleoside triphosphate biosynthetic process (GO:0009145)2.96084502
52tRNA processing (GO:0008033)2.92550172
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.91419865
54replication fork processing (GO:0031297)2.89185571
55rRNA catabolic process (GO:0016075)2.88889562
56hydrogen ion transmembrane transport (GO:1902600)2.84824514
57positive regulation of fatty acid transport (GO:2000193)2.83764329
58protein-cofactor linkage (GO:0018065)2.82027824
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80506978
60proton transport (GO:0015992)2.79990914
61nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77371893
62cellular response to interferon-beta (GO:0035458)2.76725123
63L-serine metabolic process (GO:0006563)2.76669675
64negative regulation of complement activation (GO:0045916)2.75904612
65hydrogen transport (GO:0006818)2.74265610
66regulation of microtubule-based movement (GO:0060632)2.74222400
67somite development (GO:0061053)2.73246440
68regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72879955
69viral transcription (GO:0019083)2.71020037
70tRNA metabolic process (GO:0006399)2.68599778
71piRNA metabolic process (GO:0034587)2.67425980
72translational termination (GO:0006415)2.65647871
73retinal ganglion cell axon guidance (GO:0031290)2.65463147
74adaptation of signaling pathway (GO:0023058)2.65326178
75nucleotide transmembrane transport (GO:1901679)2.65274405
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64253722
77regulation of cellular amino acid metabolic process (GO:0006521)2.61149685
78tetrahydrofolate metabolic process (GO:0046653)2.61048963
79ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60826666
80cotranslational protein targeting to membrane (GO:0006613)2.60396139
81mechanosensory behavior (GO:0007638)2.60072161
82positive regulation of T cell apoptotic process (GO:0070234)2.59114736
83protein targeting to ER (GO:0045047)2.58441431
84intracellular protein transmembrane transport (GO:0065002)2.57793451
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.56199340
86ribosomal small subunit biogenesis (GO:0042274)2.55917743
87response to pheromone (GO:0019236)2.55435864
88GTP biosynthetic process (GO:0006183)2.55067286
89negative regulation of multicellular organism growth (GO:0040015)2.54274238
90photoreceptor cell maintenance (GO:0045494)2.53758104
91cullin deneddylation (GO:0010388)2.52987884
92DNA strand renaturation (GO:0000733)2.52689107
93protein heterotetramerization (GO:0051290)2.52282853
94intraciliary transport (GO:0042073)2.52218335
95translational elongation (GO:0006414)2.51916963
96serine family amino acid catabolic process (GO:0009071)2.51336769
97protein localization to endoplasmic reticulum (GO:0070972)2.50957636
98preassembly of GPI anchor in ER membrane (GO:0016254)2.50046211
99cellular component biogenesis (GO:0044085)2.49916936
100cellular ketone body metabolic process (GO:0046950)2.49286345

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.06944947
2EZH2_22144423_ChIP-Seq_EOC_Human4.39939906
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.21482446
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59801069
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.11953330
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01491707
7VDR_22108803_ChIP-Seq_LS180_Human2.87360419
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86087053
9ZNF274_21170338_ChIP-Seq_K562_Hela2.50834881
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.46926652
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12368252
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.11992373
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09128376
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08168151
15ELK1_19687146_ChIP-ChIP_HELA_Human1.97268634
16ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93384744
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.83331855
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79901207
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79477119
20VDR_23849224_ChIP-Seq_CD4+_Human1.75395950
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.73525714
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70172188
23YY1_21170310_ChIP-Seq_MESCs_Mouse1.58221994
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57168480
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.56236502
26IRF1_19129219_ChIP-ChIP_H3396_Human1.55893346
27MYC_18940864_ChIP-ChIP_HL60_Human1.55630598
28EWS_26573619_Chip-Seq_HEK293_Human1.53510825
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53457830
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.52136151
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.51703193
32POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49521330
33TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49521330
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48020078
35FUS_26573619_Chip-Seq_HEK293_Human1.45430584
36PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44813503
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44187106
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43345949
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.41340493
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.40798411
41FOXP3_21729870_ChIP-Seq_TREG_Human1.40327702
42TTF2_22483619_ChIP-Seq_HELA_Human1.37257882
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37184991
44P300_19829295_ChIP-Seq_ESCs_Human1.36027892
45TAF15_26573619_Chip-Seq_HEK293_Human1.35034340
46MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34834730
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33878788
48GBX2_23144817_ChIP-Seq_PC3_Human1.32546478
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32376708
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.26448325
51TP53_22573176_ChIP-Seq_HFKS_Human1.26355561
52TAF2_19829295_ChIP-Seq_ESCs_Human1.25898313
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24233377
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24062456
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19437247
56SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19103713
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18065023
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18016649
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16824842
60NCOR_22424771_ChIP-Seq_293T_Human1.16123162
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15762411
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13883930
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10356641
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.09643200
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09600647
66NANOG_19829295_ChIP-Seq_ESCs_Human1.08099067
67SOX2_19829295_ChIP-Seq_ESCs_Human1.08099067
68REST_21632747_ChIP-Seq_MESCs_Mouse1.07401803
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.04862189
70GABP_19822575_ChIP-Seq_HepG2_Human1.04208535
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.03022335
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03022335
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00603289
74SOX2_16153702_ChIP-ChIP_HESCs_Human0.99383503
75FOXH1_21741376_ChIP-Seq_EPCs_Human0.98804601
76BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98505115
77TCF4_22108803_ChIP-Seq_LS180_Human0.97034929
78PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96537881
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93396554
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93163067
81PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91486441
82MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91093616
83TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89385343
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.89336409
85SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88904433
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.88370905
87NANOG_20526341_ChIP-Seq_ESCs_Human0.88174423
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.86888521
89MYC_19829295_ChIP-Seq_ESCs_Human0.86683406
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86149808
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.86083221
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85407833
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85249500
94RNF2_27304074_Chip-Seq_NSC_Mouse0.84816620
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84693545
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.84651270
97HOXB7_26014856_ChIP-Seq_BT474_Human0.83830945
98IGF1R_20145208_ChIP-Seq_DFB_Human0.83810622
99EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83734202
100MYC_19079543_ChIP-ChIP_MESCs_Mouse0.83589386

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.42060884
2MP0002638_abnormal_pupillary_reflex3.36064206
3MP0002234_abnormal_pharynx_morphology2.96823233
4MP0003880_abnormal_central_pattern2.89190013
5MP0003787_abnormal_imprinting2.84181140
6MP0008877_abnormal_DNA_methylation2.83528145
7MP0003646_muscle_fatigue2.62291757
8MP0006292_abnormal_olfactory_placode2.44547285
9MP0003011_delayed_dark_adaptation2.33696426
10MP0002163_abnormal_gland_morphology2.27779363
11MP0005551_abnormal_eye_electrophysiolog2.27693632
12MP0002736_abnormal_nociception_after2.23267091
13MP0009379_abnormal_foot_pigmentation2.17181598
14MP0001502_abnormal_circadian_rhythm2.13078483
15MP0004885_abnormal_endolymph2.10339968
16MP0005253_abnormal_eye_physiology1.99123395
17MP0004142_abnormal_muscle_tone1.90367135
18MP0004742_abnormal_vestibular_system1.89787672
19MP0001968_abnormal_touch/_nociception1.86152107
20MP0003136_yellow_coat_color1.85431978
21MP0008789_abnormal_olfactory_epithelium1.83859992
22MP0006054_spinal_hemorrhage1.83274462
23MP0006072_abnormal_retinal_apoptosis1.79872859
24MP0003123_paternal_imprinting1.79614699
25MP0001485_abnormal_pinna_reflex1.77668465
26MP0001661_extended_life_span1.73394103
27MP0001984_abnormal_olfaction1.66844039
28MP0004145_abnormal_muscle_electrophysio1.57809871
29MP0002272_abnormal_nervous_system1.57172000
30MP0009053_abnormal_anal_canal1.52734145
31MP0003283_abnormal_digestive_organ1.50381179
32MP0008872_abnormal_physiological_respon1.50145993
33MP0002876_abnormal_thyroid_physiology1.47465498
34MP0000778_abnormal_nervous_system1.44429391
35MP0004133_heterotaxia1.44212234
36MP0003121_genomic_imprinting1.43078495
37MP0002837_dystrophic_cardiac_calcinosis1.42571212
38MP0006276_abnormal_autonomic_nervous1.41366118
39MP0003122_maternal_imprinting1.40720327
40MP0002138_abnormal_hepatobiliary_system1.40654218
41MP0005499_abnormal_olfactory_system1.38775305
42MP0005394_taste/olfaction_phenotype1.38775305
43MP0000049_abnormal_middle_ear1.36951127
44MP0008875_abnormal_xenobiotic_pharmacok1.35574010
45MP0000647_abnormal_sebaceous_gland1.34725609
46MP0000427_abnormal_hair_cycle1.33424990
47MP0004147_increased_porphyrin_level1.29812059
48MP0001348_abnormal_lacrimal_gland1.25375144
49MP0005379_endocrine/exocrine_gland_phen1.23282137
50MP0002557_abnormal_social/conspecific_i1.22485818
51MP0009046_muscle_twitch1.21368415
52MP0001293_anophthalmia1.20918319
53MP0001529_abnormal_vocalization1.20586493
54MP0009745_abnormal_behavioral_response1.19947271
55MP0002090_abnormal_vision1.18151253
56MP0003195_calcinosis1.11528514
57MP0001486_abnormal_startle_reflex1.08538956
58MP0005195_abnormal_posterior_eye1.08508707
59MP0000026_abnormal_inner_ear1.07331222
60MP0003879_abnormal_hair_cell1.04057620
61MP0001905_abnormal_dopamine_level1.03996100
62MP0005646_abnormal_pituitary_gland1.02578835
63MP0002572_abnormal_emotion/affect_behav1.02475807
64MP0003119_abnormal_digestive_system1.01034537
65MP0002160_abnormal_reproductive_system0.99717483
66MP0006035_abnormal_mitochondrial_morpho0.98946144
67MP0002752_abnormal_somatic_nervous0.97926172
68MP0004043_abnormal_pH_regulation0.97862012
69MP0002095_abnormal_skin_pigmentation0.97596582
70MP0005423_abnormal_somatic_nervous0.97374640
71MP0000685_abnormal_immune_system0.96386910
72MP0000372_irregular_coat_pigmentation0.96373441
73MP0003186_abnormal_redox_activity0.95896017
74MP0000631_abnormal_neuroendocrine_gland0.95687636
75MP0003878_abnormal_ear_physiology0.92786973
76MP0005377_hearing/vestibular/ear_phenot0.92786973
77MP0001970_abnormal_pain_threshold0.92292134
78MP0002067_abnormal_sensory_capabilities0.91799751
79MP0002229_neurodegeneration0.90595746
80MP0003786_premature_aging0.89267324
81MP0001963_abnormal_hearing_physiology0.88084128
82MP0002938_white_spotting0.87937214
83MP0005391_vision/eye_phenotype0.86761549
84MP0002184_abnormal_innervation0.86315910
85MP0001286_abnormal_eye_development0.85869631
86MP0005389_reproductive_system_phenotype0.84456955
87MP0002734_abnormal_mechanical_nocicepti0.84326559
88MP0002064_seizures0.83547176
89MP0000613_abnormal_salivary_gland0.83513778
90MP0002063_abnormal_learning/memory/cond0.82997725
91MP0003567_abnormal_fetal_cardiomyocyte0.80789735
92MP0002233_abnormal_nose_morphology0.80388663
93MP0002733_abnormal_thermal_nociception0.79344598
94MP0001501_abnormal_sleep_pattern0.79255889
95MP0003635_abnormal_synaptic_transmissio0.79074028
96MP0006036_abnormal_mitochondrial_physio0.79008283
97MP0000383_abnormal_hair_follicle0.78261235
98MP0000579_abnormal_nail_morphology0.77367865
99MP0005084_abnormal_gallbladder_morpholo0.75075403
100MP0002751_abnormal_autonomic_nervous0.74830895

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.38147519
2Acute encephalopathy (HP:0006846)4.07787082
3Hepatocellular necrosis (HP:0001404)3.97479496
4Hyperglycinemia (HP:0002154)3.91811759
5Abnormal mitochondria in muscle tissue (HP:0008316)3.87188429
6Mitochondrial inheritance (HP:0001427)3.82411566
7Increased CSF lactate (HP:0002490)3.56615164
8Hepatic necrosis (HP:0002605)3.53169960
9Progressive macrocephaly (HP:0004481)3.52974439
10Medial flaring of the eyebrow (HP:0010747)3.44847602
11Reticulocytopenia (HP:0001896)3.30304653
12Congenital, generalized hypertrichosis (HP:0004540)3.24358493
13Pancreatic cysts (HP:0001737)3.09026085
14Gait imbalance (HP:0002141)3.06279099
15Optic disc pallor (HP:0000543)3.00457329
16Pancreatic fibrosis (HP:0100732)2.99701188
17Polyphagia (HP:0002591)2.92186170
18Septo-optic dysplasia (HP:0100842)2.91642293
19Methylmalonic aciduria (HP:0012120)2.89340976
20Congenital primary aphakia (HP:0007707)2.82532717
21Methylmalonic acidemia (HP:0002912)2.78669238
22Congenital stationary night blindness (HP:0007642)2.78167940
23Abnormality of the labia minora (HP:0012880)2.72926146
24Absent phalangeal crease (HP:0006109)2.72788773
25Abnormality of midbrain morphology (HP:0002418)2.70071393
26Molar tooth sign on MRI (HP:0002419)2.70071393
27Nephrogenic diabetes insipidus (HP:0009806)2.69373835
28Coronal craniosynostosis (HP:0004440)2.66818855
29Cerebral edema (HP:0002181)2.63031448
30Abnormality of cells of the erythroid lineage (HP:0012130)2.55796987
31True hermaphroditism (HP:0010459)2.53819570
32Increased serum lactate (HP:0002151)2.50754405
33Hyperglycinuria (HP:0003108)2.42569337
34Abnormality of the renal cortex (HP:0011035)2.40113831
35Increased hepatocellular lipid droplets (HP:0006565)2.38473490
36Adrenal hypoplasia (HP:0000835)2.34826880
37Abnormal rod and cone electroretinograms (HP:0008323)2.34021099
38Abnormal finger flexion creases (HP:0006143)2.33377273
39Optic nerve hypoplasia (HP:0000609)2.32082364
40Abnormality of serum amino acid levels (HP:0003112)2.31246785
41Lipid accumulation in hepatocytes (HP:0006561)2.30649828
42Lethargy (HP:0001254)2.28026513
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27314550
44Abnormality of alanine metabolism (HP:0010916)2.27314550
45Hyperalaninemia (HP:0003348)2.27314550
46Abnormality of glycine metabolism (HP:0010895)2.24215477
47Abnormality of serine family amino acid metabolism (HP:0010894)2.24215477
48CNS demyelination (HP:0007305)2.24089949
49Sclerocornea (HP:0000647)2.22098816
50Nephronophthisis (HP:0000090)2.21640966
51Broad foot (HP:0001769)2.21112659
52Cerebral hypomyelination (HP:0006808)2.17856604
53Leukodystrophy (HP:0002415)2.16624359
54Lactic acidosis (HP:0003128)2.16292703
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.15216443
56Abnormal number of erythroid precursors (HP:0012131)2.08609382
57Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06840907
58Colon cancer (HP:0003003)2.04097668
59Increased serum pyruvate (HP:0003542)2.02678627
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01762227
61CNS hypomyelination (HP:0003429)2.01739288
62Brittle hair (HP:0002299)2.01517916
63Vaginal atresia (HP:0000148)1.97961181
64Status epilepticus (HP:0002133)1.97712464
65Respiratory failure (HP:0002878)1.97703026
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.96373037
67Genital tract atresia (HP:0001827)1.95779725
68Abnormality of DNA repair (HP:0003254)1.95513994
69Polyuria (HP:0000103)1.95509320
70Type II lissencephaly (HP:0007260)1.93638094
71Poor coordination (HP:0002370)1.92963537
72Blindness (HP:0000618)1.90986406
73Asplenia (HP:0001746)1.89791003
74Tubular atrophy (HP:0000092)1.89442969
75Pendular nystagmus (HP:0012043)1.89319798
76Occipital encephalocele (HP:0002085)1.88989422
77Atonic seizures (HP:0010819)1.88507971
78Hypoplasia of the ulna (HP:0003022)1.88069240
79Polydipsia (HP:0001959)1.87815775
80Abnormal drinking behavior (HP:0030082)1.87815775
81Retinal atrophy (HP:0001105)1.87475238
82Abnormality of the renal medulla (HP:0100957)1.85656933
83Impulsivity (HP:0100710)1.85019894
843-Methylglutaconic aciduria (HP:0003535)1.84517570
85Neonatal respiratory distress (HP:0002643)1.84318762
86Exercise intolerance (HP:0003546)1.84067553
87Abolished electroretinogram (ERG) (HP:0000550)1.82658149
88Postaxial foot polydactyly (HP:0001830)1.81871459
89Entropion (HP:0000621)1.80300165
90Double outlet right ventricle (HP:0001719)1.79836429
91Congenital malformation of the right heart (HP:0011723)1.79836429
92Papilledema (HP:0001085)1.78165336
93Abnormality of binocular vision (HP:0011514)1.77867361
94Diplopia (HP:0000651)1.77867361
95X-linked dominant inheritance (HP:0001423)1.77620549
96Renal Fanconi syndrome (HP:0001994)1.77442689
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.76747354
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.76379246
99Tachypnea (HP:0002789)1.75932995
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.74109790

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.43859663
2TRIM282.88836440
3CDC72.58209030
4PDK22.53167151
5GRK12.48238412
6TAF12.36292602
7TIE12.31841314
8MAP4K22.29509230
9EIF2AK12.16551016
10MKNK22.14363181
11DYRK22.06751069
12TSSK61.99265237
13TXK1.95514122
14WNK41.94903280
15NME11.93135814
16EPHA41.88458280
17MAP3K121.87919423
18BMPR1B1.86832737
19STK161.78883065
20FRK1.69479644
21ADRBK21.68387615
22NUAK11.66688938
23OXSR11.47978827
24STK391.46294816
25EIF2AK31.42490576
26TLK11.40507980
27VRK11.39331388
28PAK31.39120270
29NEK11.37563556
30PHKG11.36532435
31PHKG21.36532435
32EPHB21.35095220
33WNK31.29755471
34PINK11.28638849
35CSNK1G21.27440414
36CSNK1G11.25293207
37BCKDK1.23749337
38CSNK1G31.21916186
39ZAK1.21501759
40PLK21.13606692
41AKT31.09914086
42PRKCG1.07706999
43NTRK21.03747701
44PLK31.01110733
45CSNK1A1L0.99647638
46SRPK10.98630743
47TYRO30.88096788
48CDK80.87884532
49MARK10.87466392
50SIK30.87182193
51MKNK10.86185331
52CASK0.85530280
53INSRR0.82558686
54STK38L0.82318107
55MAP4K10.81518115
56CDK190.78707979
57MAPKAPK30.76813885
58TGFBR10.75859769
59MAP3K90.75559318
60DAPK30.75272080
61MAPKAPK50.74938767
62PASK0.68934767
63MINK10.64119321
64EIF2AK20.63427512
65DAPK10.60132689
66GRK50.59777439
67PRKCI0.58599118
68CSNK1E0.55312643
69BCR0.55021112
70DYRK1A0.54822062
71PRKCE0.54720131
72ATR0.53226524
73MAPK130.53151695
74CCNB10.52795143
75RPS6KA50.52200999
76PIK3CA0.51269714
77ADRBK10.49912470
78PRKACA0.49719557
79PRKCQ0.47146042
80CSNK2A20.44466038
81CDK140.44216900
82CAMK10.42851110
83SIK20.42753504
84BRAF0.42088417
85PLK10.42065796
86CSNK1A10.41560321
87AURKA0.41097494
88PLK40.39998090
89BUB10.39823465
90MAP3K40.39219693
91PRKCH0.39168003
92MST40.37543882
93CAMK2A0.37259945
94IKBKB0.36882801
95CDK180.36447605
96FES0.35976688
97AURKB0.35575059
98AKT20.35143596
99PRKCD0.35008723
100CAMKK20.34011063

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.49029032
2Proteasome_Homo sapiens_hsa030503.38920163
3One carbon pool by folate_Homo sapiens_hsa006703.00268761
4Ribosome_Homo sapiens_hsa030102.90187500
5Parkinsons disease_Homo sapiens_hsa050122.83139844
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82300325
7Protein export_Homo sapiens_hsa030602.27437368
8Propanoate metabolism_Homo sapiens_hsa006402.18672157
9Huntingtons disease_Homo sapiens_hsa050162.14387362
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10070214
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.99176237
12Alzheimers disease_Homo sapiens_hsa050101.93031273
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90499336
14Basal transcription factors_Homo sapiens_hsa030221.88998233
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88510990
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87187552
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78077898
18Cardiac muscle contraction_Homo sapiens_hsa042601.76360299
19Tryptophan metabolism_Homo sapiens_hsa003801.74085695
20Linoleic acid metabolism_Homo sapiens_hsa005911.63703147
21RNA polymerase_Homo sapiens_hsa030201.62676338
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59015677
23Steroid biosynthesis_Homo sapiens_hsa001001.57783991
24Homologous recombination_Homo sapiens_hsa034401.57367149
25beta-Alanine metabolism_Homo sapiens_hsa004101.50242263
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49376328
27RNA degradation_Homo sapiens_hsa030181.47966704
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44806477
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42388027
30Glycerolipid metabolism_Homo sapiens_hsa005611.39138405
31Phototransduction_Homo sapiens_hsa047441.36143095
32Peroxisome_Homo sapiens_hsa041461.34857259
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33957919
34Mismatch repair_Homo sapiens_hsa034301.31623511
35Butanoate metabolism_Homo sapiens_hsa006501.29596573
36Pyruvate metabolism_Homo sapiens_hsa006201.28917177
37Fanconi anemia pathway_Homo sapiens_hsa034601.28495821
38Nucleotide excision repair_Homo sapiens_hsa034201.18420250
39Histidine metabolism_Homo sapiens_hsa003401.14900408
40Fatty acid degradation_Homo sapiens_hsa000711.14329802
41Fatty acid elongation_Homo sapiens_hsa000621.13907442
42Ether lipid metabolism_Homo sapiens_hsa005651.11719931
43Selenocompound metabolism_Homo sapiens_hsa004501.09728493
44Nitrogen metabolism_Homo sapiens_hsa009101.09351463
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04384287
46Arginine and proline metabolism_Homo sapiens_hsa003301.03450796
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.03449849
48Non-homologous end-joining_Homo sapiens_hsa034500.99127278
49Collecting duct acid secretion_Homo sapiens_hsa049660.93463294
50Pyrimidine metabolism_Homo sapiens_hsa002400.90800896
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.90728889
52Nicotine addiction_Homo sapiens_hsa050330.90263100
53Lysine degradation_Homo sapiens_hsa003100.89224675
54Vitamin B6 metabolism_Homo sapiens_hsa007500.87403836
55Sulfur metabolism_Homo sapiens_hsa009200.86332913
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85691666
57Hedgehog signaling pathway_Homo sapiens_hsa043400.85581724
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.85480277
59Fat digestion and absorption_Homo sapiens_hsa049750.85170118
60Chemical carcinogenesis_Homo sapiens_hsa052040.83397225
61Metabolic pathways_Homo sapiens_hsa011000.83083623
62Basal cell carcinoma_Homo sapiens_hsa052170.79229754
63Folate biosynthesis_Homo sapiens_hsa007900.73783461
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70918856
65Caffeine metabolism_Homo sapiens_hsa002320.67182022
66RNA transport_Homo sapiens_hsa030130.66594685
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66280433
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66028374
69Purine metabolism_Homo sapiens_hsa002300.64280768
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.64207055
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64065655
72Retinol metabolism_Homo sapiens_hsa008300.64020780
73Glutathione metabolism_Homo sapiens_hsa004800.63985511
74DNA replication_Homo sapiens_hsa030300.61318682
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.58378589
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.55964854
77Biosynthesis of amino acids_Homo sapiens_hsa012300.55918859
78Sulfur relay system_Homo sapiens_hsa041220.55587806
79Olfactory transduction_Homo sapiens_hsa047400.47525906
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47095845
81Base excision repair_Homo sapiens_hsa034100.46715015
82Carbon metabolism_Homo sapiens_hsa012000.46420745
83ABC transporters_Homo sapiens_hsa020100.45461966
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44459239
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43773484
86Insulin secretion_Homo sapiens_hsa049110.43125394
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42593104
88Arachidonic acid metabolism_Homo sapiens_hsa005900.42386771
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.41839371
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.40747552
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39882908
92Morphine addiction_Homo sapiens_hsa050320.39850757
93Circadian rhythm_Homo sapiens_hsa047100.39702340
94Spliceosome_Homo sapiens_hsa030400.39389582
95Fatty acid metabolism_Homo sapiens_hsa012120.38963769
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35945730
97Glutamatergic synapse_Homo sapiens_hsa047240.32302892
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.30949584
99Pancreatic secretion_Homo sapiens_hsa049720.28913568
100Serotonergic synapse_Homo sapiens_hsa047260.27231407

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