GAPDHP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic sister chromatid separation (GO:1901970)9.53553714
2positive regulation of mitotic metaphase/anaphase transition (GO:0045842)9.53553714
3positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)9.53553714
4negative regulation of Ras GTPase activity (GO:0034261)8.94233554
5eosinophil chemotaxis (GO:0048245)8.88460986
6negative regulation of T cell receptor signaling pathway (GO:0050860)8.61037395
7eosinophil migration (GO:0072677)8.01903725
8fucose catabolic process (GO:0019317)7.88262404
9L-fucose metabolic process (GO:0042354)7.88262404
10L-fucose catabolic process (GO:0042355)7.88262404
11regulation of sister chromatid cohesion (GO:0007063)7.41833732
12regulation of mononuclear cell migration (GO:0071675)7.04627329
13negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)6.78360060
14negative regulation of peptidyl-threonine phosphorylation (GO:0010801)6.61253452
15ribosomal small subunit assembly (GO:0000028)6.45915807
16branch elongation of an epithelium (GO:0060602)6.38197936
17vesicle fusion (GO:0006906)6.34327604
18positive regulation of chromosome segregation (GO:0051984)6.13384674
19negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)5.85624917
20coenzyme A biosynthetic process (GO:0015937)5.81118532
21autophagic vacuole fusion (GO:0000046)5.56335678
22proteasome assembly (GO:0043248)5.48706746
23regulation of T cell receptor signaling pathway (GO:0050856)5.41912404
24macrophage chemotaxis (GO:0048246)5.25195048
25non-recombinational repair (GO:0000726)5.18447262
26double-strand break repair via nonhomologous end joining (GO:0006303)5.18447262
27organ growth (GO:0035265)4.94144838
28protein import into peroxisome matrix (GO:0016558)4.58583064
29positive regulation of calcium ion import (GO:0090280)4.55476963
30detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.50161711
31organelle membrane fusion (GO:0090174)4.44660494
32axis elongation (GO:0003401)4.42394900
33oxidative demethylation (GO:0070989)4.36773860
34localization within membrane (GO:0051668)4.29540412
35monocyte chemotaxis (GO:0002548)4.28634078
36metallo-sulfur cluster assembly (GO:0031163)4.22350245
37iron-sulfur cluster assembly (GO:0016226)4.22350245
38organelle fusion (GO:0048284)4.13047634
39acrosome assembly (GO:0001675)4.11767963
40fucosylation (GO:0036065)4.11404211
41fucose metabolic process (GO:0006004)4.07826213
42peptidyl-lysine dimethylation (GO:0018027)4.07783819
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)4.06437924
44detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.97380962
45preassembly of GPI anchor in ER membrane (GO:0016254)3.96495464
46regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.91739218
47seminiferous tubule development (GO:0072520)3.89158175
48negative regulation of GTPase activity (GO:0034260)3.87754835
49negative regulation of GTP catabolic process (GO:0033125)3.87754835
50negative regulation of circadian rhythm (GO:0042754)3.81651038
51pantothenate metabolic process (GO:0015939)3.81247808
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.75909487
53ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.71828546
54nucleoside bisphosphate biosynthetic process (GO:0033866)3.71828546
55purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.71828546
56DNA demethylation (GO:0080111)3.71307300
57regulation of autophagic vacuole assembly (GO:2000785)3.59790947
58coenzyme A metabolic process (GO:0015936)3.57374349
59DNA integration (GO:0015074)3.52007748
60regulation of beta-amyloid formation (GO:1902003)3.51293584
61establishment of mitotic spindle orientation (GO:0000132)3.46444506
62protein localization to peroxisome (GO:0072662)3.44838466
63protein targeting to peroxisome (GO:0006625)3.44838466
64establishment of protein localization to peroxisome (GO:0072663)3.44838466
65single-organism membrane fusion (GO:0044801)3.43047822
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.40521446
67termination of RNA polymerase III transcription (GO:0006386)3.40521446
68positive chemotaxis (GO:0050918)3.37927467
69intracellular protein transmembrane import (GO:0044743)3.33801153
70telomere maintenance via recombination (GO:0000722)3.32181095
71RNA methylation (GO:0001510)3.27616827
72ER to Golgi vesicle-mediated transport (GO:0006888)3.22351316
73mitochondrial RNA metabolic process (GO:0000959)3.16115830
74negative regulation of macroautophagy (GO:0016242)3.12267253
75folic acid-containing compound biosynthetic process (GO:0009396)3.11766674
76DNA deamination (GO:0045006)3.10420602
77regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)3.09306970
78establishment of mitotic spindle localization (GO:0040001)3.06790187
79peroxisomal transport (GO:0043574)3.03850284
80membrane budding (GO:0006900)3.02104394
81histone H3-K9 methylation (GO:0051567)2.99248129
82DNA dealkylation (GO:0035510)2.97353646
83regulation of vacuole organization (GO:0044088)2.88943642
84tRNA modification (GO:0006400)2.87638798
85regulation of amyloid precursor protein catabolic process (GO:1902991)2.86828554
86establishment of spindle orientation (GO:0051294)2.86005169
87regulation of cellular amino acid metabolic process (GO:0006521)2.85582225
88protein sumoylation (GO:0016925)2.85443351
89regulation of stem cell maintenance (GO:2000036)2.84321951
90imidazole-containing compound metabolic process (GO:0052803)2.79983589
91sodium-independent organic anion transport (GO:0043252)2.79090878
92C-terminal protein lipidation (GO:0006501)2.78975592
93GPI anchor biosynthetic process (GO:0006506)2.76668921
94GPI anchor metabolic process (GO:0006505)2.73592301
95mitotic recombination (GO:0006312)2.71799091
96regulation of T cell apoptotic process (GO:0070232)2.69441800
97lipid particle organization (GO:0034389)2.67027594
98RNA modification (GO:0009451)2.66699150
99prenylation (GO:0097354)10.4235661
100protein prenylation (GO:0018342)10.4235661

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.11330692
2GATA1_22025678_ChIP-Seq_K562_Human7.12201404
3VDR_22108803_ChIP-Seq_LS180_Human5.62829563
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.30889724
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.70948880
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.50618513
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.03510709
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86887756
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.63708717
10SRF_21415370_ChIP-Seq_HL-1_Mouse2.57381174
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53380081
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46239805
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46122924
14ZNF274_21170338_ChIP-Seq_K562_Hela2.42656133
15CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39294229
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.36089084
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25219593
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.24544135
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17072849
20AR_21572438_ChIP-Seq_LNCaP_Human2.10413345
21IRF1_19129219_ChIP-ChIP_H3396_Human2.09502747
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.02271178
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.95583475
24VDR_23849224_ChIP-Seq_CD4+_Human1.92735974
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90630499
26PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.85319529
27SRY_22984422_ChIP-ChIP_TESTIS_Rat1.69044181
28ELK1_19687146_ChIP-ChIP_HELA_Human1.54499363
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.49376805
30TAF15_26573619_Chip-Seq_HEK293_Human1.48490134
31BCAT_22108803_ChIP-Seq_LS180_Human1.36894403
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36341467
33TP53_22573176_ChIP-Seq_HFKS_Human1.35490861
34FOXP3_21729870_ChIP-Seq_TREG_Human1.35456279
35GBX2_23144817_ChIP-Seq_PC3_Human1.33386589
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.31429960
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22255711
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21124848
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21124848
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20446873
41RXR_22108803_ChIP-Seq_LS180_Human1.13092734
42GABP_19822575_ChIP-Seq_HepG2_Human1.12108495
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.10996391
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10996391
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10917792
46GATA3_26560356_Chip-Seq_TH1_Human1.10892269
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09879140
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09620477
49EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06037841
50P300_19829295_ChIP-Seq_ESCs_Human1.01352223
51DCP1A_22483619_ChIP-Seq_HELA_Human1.00503975
52HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99821677
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99504631
54FUS_26573619_Chip-Seq_HEK293_Human0.98959888
55MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98549054
56THAP11_20581084_ChIP-Seq_MESCs_Mouse0.98509235
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97438245
58HTT_18923047_ChIP-ChIP_STHdh_Human0.96191336
59IGF1R_20145208_ChIP-Seq_DFB_Human0.95897916
60ERG_20517297_ChIP-Seq_VCAP_Human0.95447648
61NFE2_27457419_Chip-Seq_LIVER_Mouse0.95408934
62P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94278205
63E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91874399
64ZNF263_19887448_ChIP-Seq_K562_Human0.91706299
65CREB1_15753290_ChIP-ChIP_HEK293T_Human0.91542706
66NANOG_19829295_ChIP-Seq_ESCs_Human0.91406326
67SOX2_19829295_ChIP-Seq_ESCs_Human0.91406326
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91253903
69CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89998595
70FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89268302
71E2F1_18555785_ChIP-Seq_MESCs_Mouse0.88618938
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88273833
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88144163
74AR_20517297_ChIP-Seq_VCAP_Human0.87317818
75EWS_26573619_Chip-Seq_HEK293_Human0.84934246
76FOXH1_21741376_ChIP-Seq_EPCs_Human0.83266319
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82404080
78TCF4_22108803_ChIP-Seq_LS180_Human0.81291600
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.80851727
80MYC_19030024_ChIP-ChIP_MESCs_Mouse0.80767486
81NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80679812
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78869560
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77992197
84TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.77744488
85NANOG_20526341_ChIP-Seq_ESCs_Human0.77720130
86POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77051634
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.74960193
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74714296
89MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.71239116
90FOXH1_21741376_ChIP-Seq_ESCs_Human0.70816763
91ELK1_22589737_ChIP-Seq_MCF10A_Human0.70597941
92TTF2_22483619_ChIP-Seq_HELA_Human0.69607941
93PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.69415333
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.68579469
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68520168
96MYC_18940864_ChIP-ChIP_HL60_Human0.68399829
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.68315324
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67799952
99AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67167894
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.66757730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.98721154
2MP0003303_peritoneal_inflammation6.99666042
3MP0006082_CNS_inflammation4.79023543
4MP0002102_abnormal_ear_morphology3.25210565
5MP0002751_abnormal_autonomic_nervous2.85693362
6MP0001663_abnormal_digestive_system2.75474289
7MP0001664_abnormal_digestion2.63256823
8MP0001919_abnormal_reproductive_system2.58567400
9MP0000467_abnormal_esophagus_morphology2.48491733
10MP0002876_abnormal_thyroid_physiology2.44338207
11MP0000383_abnormal_hair_follicle2.28096691
12MP0005381_digestive/alimentary_phenotyp2.00097831
13MP0005389_reproductive_system_phenotype1.80005692
14MP0001764_abnormal_homeostasis1.63434318
15MP0008058_abnormal_DNA_repair1.59733994
16MP0003880_abnormal_central_pattern1.58782977
17MP0003115_abnormal_respiratory_system1.57182831
18MP0002163_abnormal_gland_morphology1.54350841
19MP0005671_abnormal_response_to1.51706178
20MP0005166_decreased_susceptibility_to1.49228602
21MP0001293_anophthalmia1.46203667
22MP0003937_abnormal_limbs/digits/tail_de1.44561327
23MP0008875_abnormal_xenobiotic_pharmacok1.39542283
24MP0002837_dystrophic_cardiac_calcinosis1.39541023
25MP0010678_abnormal_skin_adnexa1.36837860
26MP0001529_abnormal_vocalization1.31429411
27MP0001986_abnormal_taste_sensitivity1.29281809
28MP0002822_catalepsy1.28471223
29MP0002138_abnormal_hepatobiliary_system1.27740150
30MP0000372_irregular_coat_pigmentation1.21748033
31MP0008877_abnormal_DNA_methylation1.20494060
32MP0003763_abnormal_thymus_physiology1.18485446
33MP0003195_calcinosis1.15409550
34MP0005379_endocrine/exocrine_gland_phen1.15164487
35MP0005084_abnormal_gallbladder_morpholo1.14285583
36MP0000490_abnormal_crypts_of1.09968954
37MP0008872_abnormal_physiological_respon1.06858628
38MP0000358_abnormal_cell_content/1.06585972
39MP0002019_abnormal_tumor_incidence1.01945287
40MP0002736_abnormal_nociception_after1.00362423
41MP0001286_abnormal_eye_development0.96523689
42MP0000026_abnormal_inner_ear0.95704127
43MP0006072_abnormal_retinal_apoptosis0.94939678
44MP0005253_abnormal_eye_physiology0.93347337
45MP0001915_intracranial_hemorrhage0.92690938
46MP0003718_maternal_effect0.91108637
47MP0001968_abnormal_touch/_nociception0.90545280
48MP0001963_abnormal_hearing_physiology0.89316050
49MP0010155_abnormal_intestine_physiology0.89181860
50MP0001984_abnormal_olfaction0.89085691
51MP0005551_abnormal_eye_electrophysiolog0.88923620
52MP0004147_increased_porphyrin_level0.88090022
53MP0005645_abnormal_hypothalamus_physiol0.87367033
54MP0000534_abnormal_ureter_morphology0.86531637
55MP0005332_abnormal_amino_acid0.85900465
56MP0003878_abnormal_ear_physiology0.85582154
57MP0005377_hearing/vestibular/ear_phenot0.85582154
58MP0002184_abnormal_innervation0.80616073
59MP0002277_abnormal_respiratory_mucosa0.76209451
60MP0009763_increased_sensitivity_to0.74795708
61MP0001835_abnormal_antigen_presentation0.74602625
62MP0004145_abnormal_muscle_electrophysio0.74359408
63MP0002210_abnormal_sex_determination0.73274382
64MP0005501_abnormal_skin_physiology0.72326378
65MP0002109_abnormal_limb_morphology0.69652046
66MP0000428_abnormal_craniofacial_morphol0.69315525
67MP0000477_abnormal_intestine_morphology0.66416880
68MP0005410_abnormal_fertilization0.65628326
69MP0005085_abnormal_gallbladder_physiolo0.64515728
70MP0002405_respiratory_system_inflammati0.63670181
71MP0009785_altered_susceptibility_to0.63002883
72MP0001800_abnormal_humoral_immune0.61694768
73MP0003011_delayed_dark_adaptation0.60993206
74MP0008789_abnormal_olfactory_epithelium0.60457477
75MP0003806_abnormal_nucleotide_metabolis0.58065202
76MP0003329_amyloid_beta_deposits0.57183649
77MP0008775_abnormal_heart_ventricle0.57100149
78MP0005397_hematopoietic_system_phenotyp0.56130191
79MP0001545_abnormal_hematopoietic_system0.56130191
80MP0003638_abnormal_response/metabolism_0.55875639
81MP0001501_abnormal_sleep_pattern0.54770441
82MP0005360_urolithiasis0.54754733
83MP0002752_abnormal_somatic_nervous0.52458810
84MP0002115_abnormal_skeleton_extremities0.52275893
85MP0003786_premature_aging0.51378108
86MP0004019_abnormal_vitamin_homeostasis0.50906971
87MP0006276_abnormal_autonomic_nervous0.49380671
88MP0005646_abnormal_pituitary_gland0.49304541
89MP0002452_abnormal_antigen_presenting0.49119275
90MP0002234_abnormal_pharynx_morphology0.48298966
91MP0002272_abnormal_nervous_system0.48287723
92MP0000858_altered_metastatic_potential0.47689113
93MP0009333_abnormal_splenocyte_physiolog0.46267384
94MP0006292_abnormal_olfactory_placode0.46243113
95MP0001119_abnormal_female_reproductive0.46010869
96MP0004885_abnormal_endolymph0.45994352
97MP0005075_abnormal_melanosome_morpholog0.45754417
98MP0000470_abnormal_stomach_morphology0.45511321
99MP0009745_abnormal_behavioral_response0.44902342
100MP0001873_stomach_inflammation0.44496896

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of long-chain fatty-acid metabolism (HP:0010964)8.58098095
2Duplicated collecting system (HP:0000081)6.87570725
3Abnormality of the renal collecting system (HP:0004742)6.16696064
4Large for gestational age (HP:0001520)6.15317370
5Long foot (HP:0001833)6.00740515
6Adactyly (HP:0009776)5.45366300
7Hypoplastic pelvis (HP:0008839)5.28119908
8Acute lymphatic leukemia (HP:0006721)5.17181711
9Abnormality of fatty-acid metabolism (HP:0004359)4.79400726
10Dry hair (HP:0011359)4.41685965
11Progressive muscle weakness (HP:0003323)4.39184789
12Autoamputation (HP:0001218)4.27297063
13Brushfield spots (HP:0001088)4.21024610
14Ureteral stenosis (HP:0000071)4.03962841
15Steatorrhea (HP:0002570)3.76955348
16Ureteral obstruction (HP:0006000)3.70413733
17Ureteral duplication (HP:0000073)3.61985586
18Severe muscular hypotonia (HP:0006829)3.50757792
19Hypoplastic nipples (HP:0002557)3.47590935
20Pulmonary artery stenosis (HP:0004415)3.34623452
21Anhidrosis (HP:0000970)3.30701172
22Reduced subcutaneous adipose tissue (HP:0003758)3.24697920
23Abnormal auditory evoked potentials (HP:0006958)3.21393521
24Broad-based gait (HP:0002136)3.19067262
25Menstrual irregularities (HP:0000858)3.06121420
26Lactic acidosis (HP:0003128)2.96180202
27Fat malabsorption (HP:0002630)2.92904302
28Acute necrotizing encephalopathy (HP:0006965)2.82109543
29Myoglobinuria (HP:0002913)2.78389952
30Rhabdomyolysis (HP:0003201)2.71079322
31Sudden death (HP:0001699)2.62243256
32Polymicrogyria (HP:0002126)2.59625619
33Epiphyseal stippling (HP:0010655)2.56422505
34Palmoplantar hyperkeratosis (HP:0000972)2.55247493
35Polyneuropathy (HP:0001271)2.53263065
36Decreased muscle mass (HP:0003199)2.53058910
37Mitochondrial inheritance (HP:0001427)2.51505460
38Abnormal mitochondria in muscle tissue (HP:0008316)2.49796789
39Chorioretinal coloboma (HP:0000567)2.49444822
40Clubbing of toes (HP:0100760)2.49340412
41Increased serum lactate (HP:0002151)2.48597031
42Acute encephalopathy (HP:0006846)2.46707150
43Palmar hyperkeratosis (HP:0010765)2.46140329
44Decreased lacrimation (HP:0000633)2.41729806
45Increased CSF lactate (HP:0002490)2.41637301
46Progressive macrocephaly (HP:0004481)2.34876827
47Stomatitis (HP:0010280)2.33881158
48Aplasia/hypoplasia of the uterus (HP:0008684)2.31238820
49Hepatocellular necrosis (HP:0001404)2.27999148
50Abnormality of vision evoked potentials (HP:0000649)2.26834654
51Transposition of the great arteries (HP:0001669)2.24635063
52Abnormal connection of the cardiac segments (HP:0011545)2.24635063
53Abnormal ventriculo-arterial connection (HP:0011563)2.24635063
54Exercise intolerance (HP:0003546)2.20741536
55Female pseudohermaphroditism (HP:0010458)2.17074975
56Wide intermamillary distance (HP:0006610)2.16271963
573-Methylglutaconic aciduria (HP:0003535)2.10885741
58Respiratory failure (HP:0002878)2.09221913
59Hepatic necrosis (HP:0002605)2.08135343
60CNS demyelination (HP:0007305)2.03957890
61Increased number of teeth (HP:0011069)2.03916122
62Pancreatic cysts (HP:0001737)1.98706460
63IgG deficiency (HP:0004315)1.97008431
64Plantar hyperkeratosis (HP:0007556)1.96557868
65True hermaphroditism (HP:0010459)1.94296594
66Broad nasal tip (HP:0000455)1.93671670
67Methylmalonic acidemia (HP:0002912)1.88999894
68Postnatal microcephaly (HP:0005484)1.86473198
69Metabolic acidosis (HP:0001942)1.86420778
70Increased IgM level (HP:0003496)1.84768711
71Cerebral edema (HP:0002181)1.83377364
72Congenital stationary night blindness (HP:0007642)1.82515294
73Abnormal epiphyseal ossification (HP:0010656)1.82424616
74Widely spaced teeth (HP:0000687)1.80381053
75Hypoplastic iliac wings (HP:0002866)1.78257823
76Aplasia/Hypoplasia of the nipples (HP:0006709)1.77166667
77Renal Fanconi syndrome (HP:0001994)1.76982985
78Increased hepatocellular lipid droplets (HP:0006565)1.72663097
79Overfolded helix (HP:0000396)1.72359363
80Hypoplasia of the uterus (HP:0000013)1.69893579
81Large hands (HP:0001176)1.69058543
82Pancreatic fibrosis (HP:0100732)1.69019721
83Anxiety (HP:0000739)1.68592605
84Generalized amyotrophy (HP:0003700)1.68121906
85Optic disc pallor (HP:0000543)1.66302616
86Hypoproteinemia (HP:0003075)1.63365538
87Lipid accumulation in hepatocytes (HP:0006561)1.63172611
88Renal cortical cysts (HP:0000803)1.63090067
89Hyperammonemia (HP:0001987)1.62875521
90Methylmalonic aciduria (HP:0012120)1.62608843
91Abnormality of the renal cortex (HP:0011035)1.61558113
92Congenital onset (HP:0003577)1.59177133
93Primary adrenal insufficiency (HP:0008207)1.58426088
94Spastic tetraplegia (HP:0002510)1.58357766
95Cerebral hypomyelination (HP:0006808)1.57340809
96Abnormality of the line of Schwalbe (HP:0008048)1.57143038
97Posterior embryotoxon (HP:0000627)1.54162058
98Flat face (HP:0012368)1.53152735
99Thickened nuchal skin fold (HP:0000474)1.49682897
100Lethargy (HP:0001254)1.48973416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK16.49668297
2TAOK24.87304611
3TAOK14.60989931
4MAP3K33.42460336
5MAP3K113.24388134
6MAP2K33.18923927
7JAK32.09386583
8MKNK210.7667504
9SRPK11.83365632
10MAP4K21.77750489
11ABL21.70479930
12DYRK1A1.59588355
13VRK21.50822965
14TRIM281.26910477
15TXK1.17532075
16MAP3K51.11465551
17TLK11.06594880
18ZAK1.03066108
19NUAK10.94629741
20TSSK60.93753845
21ADRBK20.91950641
22VRK10.91720699
23MST40.88690816
24TIE10.86476465
25NEK10.80721779
26BUB10.77932501
27GRK10.76434165
28WNK30.70711280
29CHEK20.69788143
30WNK40.68983329
31BCKDK0.64389822
32PRKCQ0.61281833
33BCR0.54597058
34TAF10.51054514
35MAP3K80.49558795
36FRK0.49291532
37MAP3K10.48363514
38KDR0.47453067
39OXSR10.47390339
40BMPR1B0.46023890
41EIF2AK30.45690599
42PLK30.45471528
43TESK10.45256213
44STK390.44147148
45PLK40.35099937
46INSRR0.35096267
47EIF2AK10.34870124
48TNIK0.34750677
49PLK20.33107899
50CSNK1G30.32864232
51DYRK20.31699224
52CSNK1A10.30001488
53CSNK1G10.29700922
54DAPK10.28075038
55CSNK1G20.27149798
56EIF2AK20.26509283
57PAK30.25050534
58GRK50.21853339
59TESK20.21313307
60SIK30.20846638
61CSNK1A1L0.19997510
62PHKG10.19580462
63PHKG20.19580462
64MAP3K120.19261298
65IGF1R0.19134195
66TAOK30.18695600
67PBK0.18651187
68ERBB30.18338367
69IKBKB0.18244031
70TEC0.18148374
71OBSCN0.17349960
72MAPK130.16612813
73MYLK0.16068905
74CSNK2A10.15160942
75CSNK2A20.14823504
76RPS6KA50.14760331
77MAP2K70.11643872
78PRKCD0.11625059
79AURKA0.11502283
80MAPKAPK50.11409477
81MAP3K40.11190198
82ABL10.10971080
83PRKCA0.09439391
84PINK10.09150981
85MAP4K10.08605162
86GRK70.08603589
87PASK0.08260433
88PRKCE0.07548711
89NME10.07020673
90LMTK20.06613559
91ITK0.06603615
92RPS6KA40.06152417
93LIMK10.05833750
94PRKCB0.05677256
95CCNB10.05502980
96IKBKE0.05268671
97PRKACA0.04858347
98MINK10.04641153
99PRKCG0.04473489
100CSNK1E0.04300913

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041305.11571373
2Proteasome_Homo sapiens_hsa030504.31255828
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007704.31020499
4RNA polymerase_Homo sapiens_hsa030203.52290435
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.15686884
6Fatty acid elongation_Homo sapiens_hsa000622.37758781
7Butanoate metabolism_Homo sapiens_hsa006502.36765398
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.23329383
9Propanoate metabolism_Homo sapiens_hsa006402.12233523
10One carbon pool by folate_Homo sapiens_hsa006702.02164717
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.98805945
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87781818
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83874997
14Oxidative phosphorylation_Homo sapiens_hsa001901.82880628
15Taste transduction_Homo sapiens_hsa047421.75133401
16Protein export_Homo sapiens_hsa030601.73649968
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54011042
18Parkinsons disease_Homo sapiens_hsa050121.52949420
19Asthma_Homo sapiens_hsa053101.45885032
20Phototransduction_Homo sapiens_hsa047441.39981736
21Tryptophan metabolism_Homo sapiens_hsa003801.39103627
22Primary immunodeficiency_Homo sapiens_hsa053401.37630497
23Peroxisome_Homo sapiens_hsa041461.33587884
24beta-Alanine metabolism_Homo sapiens_hsa004101.33255867
25Pyrimidine metabolism_Homo sapiens_hsa002401.30700855
26Allograft rejection_Homo sapiens_hsa053301.19731116
27Autoimmune thyroid disease_Homo sapiens_hsa053201.17289458
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.16949632
29Huntingtons disease_Homo sapiens_hsa050161.11031727
30Glycerolipid metabolism_Homo sapiens_hsa005611.06086735
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04260477
32Caffeine metabolism_Homo sapiens_hsa002321.02573901
33Nucleotide excision repair_Homo sapiens_hsa034201.01328190
34RNA transport_Homo sapiens_hsa030131.01270891
35Fatty acid metabolism_Homo sapiens_hsa012120.99923955
36Purine metabolism_Homo sapiens_hsa002300.99434740
37Linoleic acid metabolism_Homo sapiens_hsa005910.95107227
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94898082
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94066921
40Fatty acid degradation_Homo sapiens_hsa000710.93831004
41Lysine degradation_Homo sapiens_hsa003100.92822061
42Type I diabetes mellitus_Homo sapiens_hsa049400.89797219
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.87510808
44Basal transcription factors_Homo sapiens_hsa030220.85267607
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83842497
46RNA degradation_Homo sapiens_hsa030180.82924420
47Homologous recombination_Homo sapiens_hsa034400.77200354
48Alzheimers disease_Homo sapiens_hsa050100.75493904
49Viral myocarditis_Homo sapiens_hsa054160.75024221
50Mismatch repair_Homo sapiens_hsa034300.73391667
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72798587
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71249997
53Graft-versus-host disease_Homo sapiens_hsa053320.71047811
54Nitrogen metabolism_Homo sapiens_hsa009100.69373727
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69107007
56Carbon metabolism_Homo sapiens_hsa012000.67260621
57Sulfur metabolism_Homo sapiens_hsa009200.67257102
58Retinol metabolism_Homo sapiens_hsa008300.65968818
59Antigen processing and presentation_Homo sapiens_hsa046120.65859029
60Steroid biosynthesis_Homo sapiens_hsa001000.65015756
61Metabolic pathways_Homo sapiens_hsa011000.63668907
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.63586915
63Fat digestion and absorption_Homo sapiens_hsa049750.63395143
64Vitamin B6 metabolism_Homo sapiens_hsa007500.62821528
65DNA replication_Homo sapiens_hsa030300.61628337
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61183288
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60988943
68Systemic lupus erythematosus_Homo sapiens_hsa053220.60773816
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59948726
70Collecting duct acid secretion_Homo sapiens_hsa049660.58342895
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57180527
72Chemical carcinogenesis_Homo sapiens_hsa052040.55713089
73Epstein-Barr virus infection_Homo sapiens_hsa051690.55639832
74Rheumatoid arthritis_Homo sapiens_hsa053230.54181469
75Fanconi anemia pathway_Homo sapiens_hsa034600.54120949
76Renin-angiotensin system_Homo sapiens_hsa046140.52138195
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51917079
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51463152
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50086883
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49647499
81Arachidonic acid metabolism_Homo sapiens_hsa005900.49631629
82Non-homologous end-joining_Homo sapiens_hsa034500.49210279
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.47959902
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.47785274
85Vitamin digestion and absorption_Homo sapiens_hsa049770.47458748
86Cardiac muscle contraction_Homo sapiens_hsa042600.46885228
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46463168
88Biosynthesis of amino acids_Homo sapiens_hsa012300.45800405
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45187956
90Base excision repair_Homo sapiens_hsa034100.39845448
91Olfactory transduction_Homo sapiens_hsa047400.39638274
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.39095674
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36465346
94Ether lipid metabolism_Homo sapiens_hsa005650.35794593
95Hematopoietic cell lineage_Homo sapiens_hsa046400.35284031
96Folate biosynthesis_Homo sapiens_hsa007900.34392052
97Glutathione metabolism_Homo sapiens_hsa004800.32898499
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32628239
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.32575328
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31350487

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