GAMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a methyltransferase that converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in this gene have been implicated in neurologic syndromes and muscular hypotonia, probably due to creatine deficiency and accumulation of guanidinoacetate in the brain of affected individuals. Two transcript variants encoding different isoforms have been described for this gene. Pseudogenes of this gene are found on chromosomes 2 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.48623615
2muscle filament sliding (GO:0030049)8.48623615
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.49489294
4L-phenylalanine catabolic process (GO:0006559)7.49489294
5sarcoplasmic reticulum calcium ion transport (GO:0070296)7.05741328
6regulation of skeletal muscle contraction (GO:0014819)6.96375287
7L-phenylalanine metabolic process (GO:0006558)6.92128663
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.92128663
9actin-mediated cell contraction (GO:0070252)6.85268270
10skeletal muscle contraction (GO:0003009)6.74765737
11fatty acid elongation (GO:0030497)6.19061522
12axon ensheathment in central nervous system (GO:0032291)5.92793362
13central nervous system myelination (GO:0022010)5.92793362
14aromatic amino acid family catabolic process (GO:0009074)5.77869625
15response to muscle activity (GO:0014850)5.00836457
16glyoxylate metabolic process (GO:0046487)4.95817696
17bile acid biosynthetic process (GO:0006699)4.88302512
18striated muscle contraction (GO:0006941)4.84178580
19NADH metabolic process (GO:0006734)4.82730495
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.81753040
21regulation of relaxation of muscle (GO:1901077)4.81186755
22* creatine metabolic process (GO:0006600)4.79413034
23actin filament-based movement (GO:0030048)4.78801624
24response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.78293963
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.78174772
26cysteine metabolic process (GO:0006534)4.72252461
27skeletal muscle fiber development (GO:0048741)4.71291573
28myofibril assembly (GO:0030239)4.59958916
29alpha-linolenic acid metabolic process (GO:0036109)4.53304361
30cholesterol biosynthetic process (GO:0006695)4.46316386
31gluconeogenesis (GO:0006094)4.42969735
32glycogen catabolic process (GO:0005980)4.37031055
33sarcomere organization (GO:0045214)4.31452331
34myotube cell development (GO:0014904)4.26707518
35tryptophan catabolic process (GO:0006569)4.26062778
36indole-containing compound catabolic process (GO:0042436)4.26062778
37indolalkylamine catabolic process (GO:0046218)4.26062778
38very long-chain fatty acid metabolic process (GO:0000038)4.23020177
39high-density lipoprotein particle remodeling (GO:0034375)4.22499643
40coenzyme catabolic process (GO:0009109)4.21295739
412-oxoglutarate metabolic process (GO:0006103)4.19963355
42negative regulation of fibrinolysis (GO:0051918)4.18003270
43oxaloacetate metabolic process (GO:0006107)4.17261443
44bile acid metabolic process (GO:0008206)4.15375511
45fructose metabolic process (GO:0006000)4.13158035
46aromatic amino acid family metabolic process (GO:0009072)4.12909308
47heme transport (GO:0015886)4.12568859
48exogenous drug catabolic process (GO:0042738)4.12167540
49sulfur amino acid catabolic process (GO:0000098)4.11873943
50kynurenine metabolic process (GO:0070189)4.11649132
51regulation of fibrinolysis (GO:0051917)4.11597979
52tyrosine metabolic process (GO:0006570)4.08224138
53hexose biosynthetic process (GO:0019319)4.07983906
54regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.07263993
55protein carboxylation (GO:0018214)4.06327391
56peptidyl-glutamic acid carboxylation (GO:0017187)4.06327391
57tryptophan metabolic process (GO:0006568)4.05294565
58intestinal cholesterol absorption (GO:0030299)3.99614931
59glucan catabolic process (GO:0009251)3.98434957
60plasma lipoprotein particle clearance (GO:0034381)3.93313965
61cellular ketone body metabolic process (GO:0046950)3.92490773
62serine family amino acid biosynthetic process (GO:0009070)3.90959312
63sterol biosynthetic process (GO:0016126)3.89921470
64fatty-acyl-CoA biosynthetic process (GO:0046949)3.86647468
65cofactor catabolic process (GO:0051187)3.85058367
66regulation of cholesterol esterification (GO:0010872)3.84015565
67long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.82689635
68glucan biosynthetic process (GO:0009250)3.81392087
69glycogen biosynthetic process (GO:0005978)3.81392087
70L-serine metabolic process (GO:0006563)3.78091646
71drug catabolic process (GO:0042737)3.77897385
72aldehyde catabolic process (GO:0046185)3.76854887
73axon ensheathment (GO:0008366)3.76462881
74ensheathment of neurons (GO:0007272)3.76462881
75alpha-amino acid catabolic process (GO:1901606)3.73694891
76myelination (GO:0042552)3.73584753
77monosaccharide biosynthetic process (GO:0046364)3.72154923
78cellular polysaccharide catabolic process (GO:0044247)3.71185883
79short-chain fatty acid metabolic process (GO:0046459)3.70321420
80acetyl-CoA metabolic process (GO:0006084)3.70135824
81* muscle contraction (GO:0006936)3.68487113
82urea metabolic process (GO:0019627)3.66357796
83urea cycle (GO:0000050)3.66357796
84regulation of triglyceride catabolic process (GO:0010896)3.66265519
85complement activation, alternative pathway (GO:0006957)3.65782833
86reverse cholesterol transport (GO:0043691)3.62716852
87nitrogen cycle metabolic process (GO:0071941)3.61473547
88regulation of protein activation cascade (GO:2000257)3.61469253
89tricarboxylic acid cycle (GO:0006099)3.61279974
90fatty-acyl-CoA metabolic process (GO:0035337)3.59348062
91ethanol oxidation (GO:0006069)3.56617983
92plasma lipoprotein particle remodeling (GO:0034369)3.55295361
93protein-lipid complex remodeling (GO:0034368)3.55295361
94macromolecular complex remodeling (GO:0034367)3.55295361
95serine family amino acid metabolic process (GO:0009069)3.54636037
96cardiac myofibril assembly (GO:0055003)3.54317801
97ubiquinone biosynthetic process (GO:0006744)3.54249963
98cholesterol efflux (GO:0033344)3.53371339
99cellular amino acid catabolic process (GO:0009063)3.52990304
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52254984
101serine family amino acid catabolic process (GO:0009071)3.50630899
102aspartate family amino acid catabolic process (GO:0009068)3.48714905
103acylglycerol homeostasis (GO:0055090)3.47682649
104triglyceride homeostasis (GO:0070328)3.47682649
105response to inactivity (GO:0014854)3.47248334
106cardiac muscle contraction (GO:0060048)3.47008301
107response to mercury ion (GO:0046689)3.46001990
108acyl-CoA biosynthetic process (GO:0071616)3.44967575
109thioester biosynthetic process (GO:0035384)3.44967575
110quinone biosynthetic process (GO:1901663)3.44018772
111ketone body metabolic process (GO:1902224)3.43990436
112regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.43815217
113positive regulation of lipoprotein lipase activity (GO:0051006)3.42555473
114positive regulation of triglyceride lipase activity (GO:0061365)3.42555473
115homocysteine metabolic process (GO:0050667)3.42170249
116thioester metabolic process (GO:0035383)3.39865349
117acyl-CoA metabolic process (GO:0006637)3.39865349
118glutamate metabolic process (GO:0006536)3.38740106
119opsonization (GO:0008228)3.36842365
120cholesterol metabolic process (GO:0008203)3.35325479
121regulation of complement activation (GO:0030449)3.33628330
122cellular biogenic amine catabolic process (GO:0042402)3.32360252
123amine catabolic process (GO:0009310)3.32360252
124oxidative phosphorylation (GO:0006119)3.30579990
125negative regulation of cholesterol transport (GO:0032375)3.29541999
126negative regulation of sterol transport (GO:0032372)3.29541999
127muscle fiber development (GO:0048747)3.28379484
128positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.28308396
129cellular modified amino acid catabolic process (GO:0042219)3.28123186
130polysaccharide catabolic process (GO:0000272)3.27324400
131long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26120400
132* muscle system process (GO:0003012)3.25849608
133muscle cell fate commitment (GO:0042693)3.24277699
134cholesterol homeostasis (GO:0042632)3.23101565
135actomyosin structure organization (GO:0031032)3.21299465
136response to methylmercury (GO:0051597)3.20776938
137phospholipid efflux (GO:0033700)3.20091351
138fibrinolysis (GO:0042730)3.19787156
139glycine metabolic process (GO:0006544)3.19151319
140skeletal muscle adaptation (GO:0043501)3.18374232
141very-low-density lipoprotein particle assembly (GO:0034379)3.18240324
142epoxygenase P450 pathway (GO:0019373)3.18140833
143blood coagulation, intrinsic pathway (GO:0007597)3.17625055
144sterol homeostasis (GO:0055092)3.15428696
145carboxylic acid catabolic process (GO:0046395)3.15294438
146organic acid catabolic process (GO:0016054)3.15294438
147iron coordination entity transport (GO:1901678)3.14639824
148cellular glucuronidation (GO:0052695)3.13866009
149sterol metabolic process (GO:0016125)3.13808864
150regulation of cholesterol metabolic process (GO:0090181)3.13529184
151muscle organ morphogenesis (GO:0048644)3.12446906
152negative regulation of lipase activity (GO:0060192)3.11941855
153plasma membrane repair (GO:0001778)3.11019002
154ubiquinone metabolic process (GO:0006743)3.10345663
155negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.09841012
156muscle cell cellular homeostasis (GO:0046716)3.09350764
157regulation of plasminogen activation (GO:0010755)3.06840763
158glycogen metabolic process (GO:0005977)3.05006833
159regulation of actin filament-based movement (GO:1903115)3.04087509
160regulation of glucokinase activity (GO:0033131)3.00755271
161regulation of hexokinase activity (GO:1903299)3.00755271
162amino-acid betaine metabolic process (GO:0006577)2.98223251
163regulation of cell communication by electrical coupling (GO:0010649)2.97444029
164glucan metabolic process (GO:0044042)2.94985139
165cellular glucan metabolic process (GO:0006073)2.94985139
166oxidative demethylation (GO:0070989)2.93583727
167omega-hydroxylase P450 pathway (GO:0097267)2.92443019
168branched-chain amino acid catabolic process (GO:0009083)2.92300050
169skeletal muscle tissue development (GO:0007519)2.91293453
170L-methionine biosynthetic process (GO:0071265)2.84403726
171amino acid salvage (GO:0043102)2.84403726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.53829406
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.87498559
3EGR1_23403033_ChIP-Seq_LIVER_Mouse4.91150407
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.84717514
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.84650104
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.90043810
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.59473505
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.14151612
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.12187505
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.94334384
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71733125
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.50763452
13BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.38386078
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37220218
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.32595298
16* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20454727
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.09614503
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.07339469
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07186558
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.05625011
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95675960
22SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.93158950
23HTT_18923047_ChIP-ChIP_STHdh_Human1.91120474
24LXR_22292898_ChIP-Seq_THP-1_Human1.87640115
25TET1_21451524_ChIP-Seq_MESCs_Mouse1.86102923
26ZNF263_19887448_ChIP-Seq_K562_Human1.80279338
27TAF15_26573619_Chip-Seq_HEK293_Human1.78309805
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.76742890
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76644295
30CTCF_27219007_Chip-Seq_Bcells_Human1.73999690
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70069297
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68295242
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67185613
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63355898
35* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.63170952
36* P68_20966046_ChIP-Seq_HELA_Human1.61682228
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.59272640
38ETS1_20019798_ChIP-Seq_JURKAT_Human1.58186025
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52795928
40SA1_27219007_Chip-Seq_Bcells_Human1.44095474
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.42715489
42YY1_22570637_ChIP-Seq_MALME-3M_Human1.42306060
43BCL6_27268052_Chip-Seq_Bcells_Human1.36385973
44* FOXP1_21924763_ChIP-Seq_HESCs_Human1.32816992
45CTCF_26484167_Chip-Seq_Bcells_Mouse1.28980582
46* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28659458
47GBX2_23144817_ChIP-Seq_PC3_Human1.28241254
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27084340
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26418037
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24725771
51SPI1_20517297_ChIP-Seq_HL60_Human1.24564876
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.24418039
53MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24389768
54SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.23309178
55* E2F1_20622854_ChIP-Seq_HELA_Human1.22972220
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22785072
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22448631
58CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22440445
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22362779
60SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20969428
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19337452
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18637944
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18125306
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18125306
65SMC3_22415368_ChIP-Seq_MEFs_Mouse1.18010098
66* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.17843054
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.17067641
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16977959
69CTCF_21964334_Chip-Seq_Bcells_Human1.16269961
70RARB_24833708_ChIP-Seq_LIVER_Mouse1.15821014
71PHF8_20622854_ChIP-Seq_HELA_Human1.15149303
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13978627
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.13512878
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.13512878
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12200631
76* BCOR_27268052_Chip-Seq_Bcells_Human1.11830842
77SMC4_20622854_ChIP-Seq_HELA_Human1.11557864
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11356030
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11136634
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.10970829
81GABP_19822575_ChIP-Seq_HepG2_Human1.10762907
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10321230
83STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10025213
84SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09546062
85GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09530266
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.09000656
87* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08717412
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05054412
89MYC_18555785_ChIP-Seq_MESCs_Mouse1.04567324
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04294399
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04017065
92EZH2_22144423_ChIP-Seq_EOC_Human1.03651707
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02623723
94* XRN2_22483619_ChIP-Seq_HELA_Human1.02567105
95STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02403089
96* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02267673
97MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02187849
98PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01259564
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01002534
100* RAC3_21632823_ChIP-Seq_H3396_Human1.00740083
101EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00282886
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99501740
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99371494
104TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97967122
105* ETS1_21867929_ChIP-Seq_TH2_Mouse0.97104839
106ERG_21242973_ChIP-ChIP_JURKAT_Human0.96304145
107ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94689481
108ESR2_21235772_ChIP-Seq_MCF-7_Human0.94109432
109FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93699899
110DCP1A_22483619_ChIP-Seq_HELA_Human0.91365187
111MTF2_20144788_ChIP-Seq_MESCs_Mouse0.91353419
112EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.90650849
113ER_23166858_ChIP-Seq_MCF-7_Human0.90058708
114* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89133719
115SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88799586
116AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87764638
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87479375
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85680923
119* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.83499593
120SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82924197
121CBP_21632823_ChIP-Seq_H3396_Human0.82818746
122CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82786303
123FOXA1_25552417_ChIP-Seq_VCAP_Human0.82663023
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82552074
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.82256082
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80551333
127RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79977215
128EOMES_21245162_ChIP-Seq_HESCs_Human0.79572461
129OCT4_20526341_ChIP-Seq_ESCs_Human0.78745712
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78645875
131IRF1_19129219_ChIP-ChIP_H3396_Human0.78406690
132WT1_19549856_ChIP-ChIP_CCG9911_Human0.78104516
133NCOR_22424771_ChIP-Seq_293T_Human0.75778049
134CLOCK_20551151_ChIP-Seq_293T_Human0.74128209
135EZH2_27294783_Chip-Seq_ESCs_Mouse0.74104709
136TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72526775
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72170066
138VDR_22108803_ChIP-Seq_LS180_Human0.71820982
139GATA4_25053715_ChIP-Seq_YYC3_Human0.71710709
140SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71106392
141RXRA_24833708_ChIP-Seq_LIVER_Mouse0.70613297
142VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.70597715
143* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.70220362
144EGR1_19032775_ChIP-ChIP_M12_Human0.70187432
145MYC_19915707_ChIP-ChIP_AK7_Human0.70043570
146CTCF_20526341_ChIP-Seq_ESCs_Human0.69758900
147FOXO3_23340844_ChIP-Seq_DLD1_Human0.68499680
148EED_16625203_ChIP-ChIP_MESCs_Mouse0.68457461
149NANOG_19829295_ChIP-Seq_ESCs_Human0.67744711
150SOX2_19829295_ChIP-Seq_ESCs_Human0.67744711
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67265888
152* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.67248480
153P53_21459846_ChIP-Seq_SAOS-2_Human0.66891887
154SMAD3_21741376_ChIP-Seq_EPCs_Human0.66504188
155TAL1_26923725_Chip-Seq_HPCs_Mouse0.66255986
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.65908993
157GATA1_19941826_ChIP-Seq_K562_Human0.65480195
158SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65298176
159TRIM28_21343339_ChIP-Seq_HEK293_Human0.65236582
160ESET_19884257_ChIP-Seq_ESCs_Mouse0.65104490
161RNF2_18974828_ChIP-Seq_MESCs_Mouse0.64955350
162EZH2_18974828_ChIP-Seq_MESCs_Mouse0.64955350
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.64121847
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.64097186
165SMAD4_21741376_ChIP-Seq_EPCs_Human0.63735788
166P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.63545157
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.63515521
168SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.63385578
169RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63308550
170PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.62814503
171SOX2_20726797_ChIP-Seq_SW620_Human0.62664565
172THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.62631606
173ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61867985
174SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.61592588
175EP300_21415370_ChIP-Seq_HL-1_Mouse0.61456658

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.61112856
2MP0003646_muscle_fatigue5.95088713
3MP0004145_abnormal_muscle_electrophysio5.93355909
4MP0005360_urolithiasis5.91982863
5MP0005365_abnormal_bile_salt5.30669001
6MP0005085_abnormal_gallbladder_physiolo5.28074992
7MP0000751_myopathy5.26909060
8MP0000749_muscle_degeneration5.00348782
9MP0003806_abnormal_nucleotide_metabolis4.76281081
10MP0008875_abnormal_xenobiotic_pharmacok4.21352114
11MP0005083_abnormal_biliary_tract3.93088558
12MP0004036_abnormal_muscle_relaxation3.63981408
13MP0002106_abnormal_muscle_physiology3.25631747
14MP0001666_abnormal_nutrient_absorption3.19278895
15MP0000920_abnormal_myelination3.18971934
16MP0003195_calcinosis3.15036718
17MP0000759_abnormal_skeletal_muscle3.00620711
18MP0009840_abnormal_foam_cell3.00003273
19MP0004087_abnormal_muscle_fiber2.86627461
20MP0002269_muscular_atrophy2.77348537
21MP0005369_muscle_phenotype2.74661323
22MP0003252_abnormal_bile_duct2.70412735
23MP0004233_abnormal_muscle_weight2.66600568
24MP0005330_cardiomyopathy2.65426997
25MP0010329_abnormal_lipoprotein_level2.57111934
26MP0002332_abnormal_exercise_endurance2.52638140
27* MP0005332_abnormal_amino_acid2.41811660
28MP0000750_abnormal_muscle_regeneration2.40540579
29MP0002837_dystrophic_cardiac_calcinosis2.38310111
30MP0004084_abnormal_cardiac_muscle2.26605403
31MP0003690_abnormal_glial_cell2.24506654
32MP0004130_abnormal_muscle_cell2.23952746
33MP0005620_abnormal_muscle_contractility2.23830417
34MP0002118_abnormal_lipid_homeostasis2.09241789
35MP0003329_amyloid_beta_deposits2.00628364
36MP0003868_abnormal_feces_composition1.98128195
37MP0003191_abnormal_cellular_cholesterol1.71581450
38MP0005670_abnormal_white_adipose1.71202327
39MP0003950_abnormal_plasma_membrane1.69092746
40MP0002972_abnormal_cardiac_muscle1.69015641
41MP0000013_abnormal_adipose_tissue1.67471890
42MP0000604_amyloidosis1.66014427
43MP0000733_abnormal_muscle_development1.62928126
44MP0005584_abnormal_enzyme/coenzyme_acti1.52050549
45MP0002108_abnormal_muscle_morphology1.48918107
46MP0000609_abnormal_liver_physiology1.48214168
47MP0005408_hypopigmentation1.45364626
48MP0003656_abnormal_erythrocyte_physiolo1.36619369
49MP0001661_extended_life_span1.35079820
50MP0003011_delayed_dark_adaptation1.33397887
51MP0004019_abnormal_vitamin_homeostasis1.33032562
52MP0004215_abnormal_myocardial_fiber1.30557609
53MP0003186_abnormal_redox_activity1.28592257
54MP0000003_abnormal_adipose_tissue1.24686051
55MP0005319_abnormal_enzyme/_coenzyme1.20117013
56MP0004142_abnormal_muscle_tone1.19097030
57MP0002822_catalepsy1.18140673
58MP0001764_abnormal_homeostasis1.17222638
59MP0010630_abnormal_cardiac_muscle1.16472029
60MP0004885_abnormal_endolymph1.16332780
61MP0004381_abnormal_hair_follicle1.12330097
62MP0001529_abnormal_vocalization1.11541523
63MP0009697_abnormal_copulation1.09837088
64MP0005220_abnormal_exocrine_pancreas1.08789446
65MP0001905_abnormal_dopamine_level1.08664957
66MP0004270_analgesia1.08270525
67MP0003634_abnormal_glial_cell1.07568947
68MP0003137_abnormal_impulse_conducting1.05102028
69MP0002127_abnormal_cardiovascular_syste1.04015559
70MP0005084_abnormal_gallbladder_morpholo1.03294814
71MP0002138_abnormal_hepatobiliary_system1.01483360
72MP0003632_abnormal_nervous_system1.01471758
73MP0000372_irregular_coat_pigmentation0.98752120
74MP0002229_neurodegeneration0.98634171
75MP0005385_cardiovascular_system_phenoty0.97515382
76MP0001544_abnormal_cardiovascular_syste0.97515382
77MP0005375_adipose_tissue_phenotype0.96597123
78MP0004484_altered_response_of0.95323713
79MP0010030_abnormal_orbit_morphology0.93487449
80MP0005058_abnormal_lysosome_morphology0.93334324
81MP0003879_abnormal_hair_cell0.91442966
82MP0006138_congestive_heart_failure0.89517986
83* MP0009643_abnormal_urine_homeostasis0.88786653
84MP0004043_abnormal_pH_regulation0.87989897
85MP0009765_abnormal_xenobiotic_induced0.87832851
86MP0005666_abnormal_adipose_tissue0.86728212
87MP0003880_abnormal_central_pattern0.85376387
88MP0005647_abnormal_sex_gland0.85013048
89MP0008775_abnormal_heart_ventricle0.84819688
90MP0004147_increased_porphyrin_level0.84724644
91MP0005410_abnormal_fertilization0.83279279
92MP0006035_abnormal_mitochondrial_morpho0.81543303
93MP0000462_abnormal_digestive_system0.80887268
94MP0004510_myositis0.80776469
95MP0002272_abnormal_nervous_system0.79535455
96MP0004742_abnormal_vestibular_system0.79173874
97MP0009763_increased_sensitivity_to0.77796351
98MP0000639_abnormal_adrenal_gland0.76491904
99MP0002234_abnormal_pharynx_morphology0.74899261
100MP0008438_abnormal_cutaneous_collagen0.73793029
101MP0005636_abnormal_mineral_homeostasis0.73527076
102MP0001485_abnormal_pinna_reflex0.73330619
103MP0000598_abnormal_liver_morphology0.71885964
104MP0002295_abnormal_pulmonary_circulatio0.71508678
105MP0001346_abnormal_lacrimal_gland0.70073126
106MP0005551_abnormal_eye_electrophysiolog0.69171032
107MP0000747_muscle_weakness0.68219245
108MP0006082_CNS_inflammation0.68125820
109MP0003631_nervous_system_phenotype0.68019060
110MP0001486_abnormal_startle_reflex0.67716179
111MP0009780_abnormal_chondrocyte_physiolo0.67431603
112MP0003221_abnormal_cardiomyocyte_apopto0.66386447
113MP0003136_yellow_coat_color0.65714937
114MP0008260_abnormal_autophagy0.65156859
115* MP0006036_abnormal_mitochondrial_physio0.64602799
116MP0002249_abnormal_larynx_morphology0.64414292
117MP0010678_abnormal_skin_adnexa0.63733059
118MP0005376_homeostasis/metabolism_phenot0.62931232
119MP0005535_abnormal_body_temperature0.62426749
120* MP0005451_abnormal_body_composition0.61996205
121MP0000647_abnormal_sebaceous_gland0.58859438
122MP0005171_absent_coat_pigmentation0.58518318
123* MP0009642_abnormal_blood_homeostasis0.57916555
124MP0002064_seizures0.57341861
125MP0002090_abnormal_vision0.57187075
126MP0004085_abnormal_heartbeat0.56420168
127MP0004185_abnormal_adipocyte_glucose0.54879386
128MP0003633_abnormal_nervous_system0.54875687
129MP0000778_abnormal_nervous_system0.54644187
130MP0000579_abnormal_nail_morphology0.54597960
131MP0008469_abnormal_protein_level0.53813041
132MP0002971_abnormal_brown_adipose0.53595369
133MP0002078_abnormal_glucose_homeostasis0.52357130
134MP0005645_abnormal_hypothalamus_physiol0.51882279
135MP0008874_decreased_physiological_sensi0.51676513
136MP0000383_abnormal_hair_follicle0.51256926
137MP0009384_cardiac_valve_regurgitation0.50887455
138MP0008872_abnormal_physiological_respon0.50834424
139MP0005448_abnormal_energy_balance0.48735492
140MP0005195_abnormal_posterior_eye0.48087455
141MP0003718_maternal_effect0.47570945
142* MP0005452_abnormal_adipose_tissue0.47509926
143MP0005266_abnormal_metabolism0.46322011
144MP0002876_abnormal_thyroid_physiology0.46156853
145MP0003638_abnormal_response/metabolism_0.45057491
146MP0005334_abnormal_fat_pad0.44547367
147MP0005187_abnormal_penis_morphology0.42808775
148MP0000230_abnormal_systemic_arterial0.42607107
149MP0000955_abnormal_spinal_cord0.42527488
150MP0000566_synostosis0.42273470
151MP0003075_altered_response_to0.41487226
152MP0008873_increased_physiological_sensi0.41220288
153MP0004134_abnormal_chest_morphology0.39660116
154MP0006276_abnormal_autonomic_nervous0.35919576
155MP0000266_abnormal_heart_morphology0.35451184

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)9.44808650
2Nemaline bodies (HP:0003798)9.41585520
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)9.09692477
4Exercise-induced myalgia (HP:0003738)7.45505194
5Type 1 muscle fiber predominance (HP:0003803)6.94169106
6Abnormality of aromatic amino acid family metabolism (HP:0004338)6.85952034
7Exercise-induced muscle cramps (HP:0003710)6.70790395
8Intrahepatic cholestasis (HP:0001406)6.13381155
9Deep venous thrombosis (HP:0002625)5.82996987
10Muscle hypertrophy of the lower extremities (HP:0008968)5.46936039
11Distal arthrogryposis (HP:0005684)5.42805008
12Myopathic facies (HP:0002058)5.40346989
13Prolonged partial thromboplastin time (HP:0003645)4.98072128
14Xanthomatosis (HP:0000991)4.94506513
15Rhabdomyolysis (HP:0003201)4.90827633
16Hyperlipoproteinemia (HP:0010980)4.90802632
17Calf muscle hypertrophy (HP:0008981)4.83428496
18Myoglobinuria (HP:0002913)4.75291674
19Round ear (HP:0100830)4.67522395
20Abnormality of monocarboxylic acid metabolism (HP:0010996)4.67081577
21Hypobetalipoproteinemia (HP:0003563)4.66151513
22EMG: myopathic abnormalities (HP:0003458)4.60766867
23Ulnar deviation of the wrist (HP:0003049)4.16650774
24Neurofibrillary tangles (HP:0002185)4.12905177
25Centrally nucleated skeletal muscle fibers (HP:0003687)4.06901110
26Fat malabsorption (HP:0002630)3.95193321
27Abnormality of the calf musculature (HP:0001430)3.88251086
28Abnormality of methionine metabolism (HP:0010901)3.86717393
29Calcaneovalgus deformity (HP:0001848)3.78178026
30Hyporeflexia of lower limbs (HP:0002600)3.73049428
31Muscle fiber splitting (HP:0003555)3.72944653
32Rimmed vacuoles (HP:0003805)3.66459221
33Neck muscle weakness (HP:0000467)3.64650687
34Abnormality of skeletal muscle fiber size (HP:0012084)3.64503001
35Muscle stiffness (HP:0003552)3.62323084
36Steatorrhea (HP:0002570)3.59861784
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.56830881
38Degeneration of the lateral corticospinal tracts (HP:0002314)3.55716235
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.55716235
40Complement deficiency (HP:0004431)3.47460496
41Hyperammonemia (HP:0001987)3.47211853
42Subaortic stenosis (HP:0001682)3.45978128
43Abnormality of the left ventricular outflow tract (HP:0011103)3.45978128
44Hyperglycinemia (HP:0002154)3.45367899
45Ketosis (HP:0001946)3.44488790
46Abnormality of serine family amino acid metabolism (HP:0010894)3.40550345
47Abnormality of glycine metabolism (HP:0010895)3.40550345
48Deformed tarsal bones (HP:0008119)3.36303297
49Absent phalangeal crease (HP:0006109)3.33347258
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.29555846
51Hypolipoproteinemia (HP:0010981)3.28701113
52Abnormality of sulfur amino acid metabolism (HP:0004339)3.23855530
53Epidermoid cyst (HP:0200040)3.23588903
54Parakeratosis (HP:0001036)3.22316006
55Sensory axonal neuropathy (HP:0003390)3.21318497
56Joint hemorrhage (HP:0005261)3.20895420
57Abnormality of glycolysis (HP:0004366)3.11857249
58Increased serum pyruvate (HP:0003542)3.11857249
59Abnormality of the common coagulation pathway (HP:0010990)3.11822911
60Asymmetric septal hypertrophy (HP:0001670)3.03892543
61Myotonia (HP:0002486)3.03878148
62Cerebral inclusion bodies (HP:0100314)3.01411050
63Conjugated hyperbilirubinemia (HP:0002908)3.01306124
64Increased variability in muscle fiber diameter (HP:0003557)2.97367281
65Increased connective tissue (HP:0009025)2.94714003
66Malignant hyperthermia (HP:0002047)2.94077368
67Spastic paraparesis (HP:0002313)2.93117185
68Distal lower limb muscle weakness (HP:0009053)2.89907077
69Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81310315
70Areflexia of lower limbs (HP:0002522)2.77840393
71Abnormality of the corticospinal tract (HP:0002492)2.77586887
72Cerebral edema (HP:0002181)2.76993705
73Abnormality of fatty-acid metabolism (HP:0004359)2.73562957
74Hyperglycinuria (HP:0003108)2.73098220
75Sudden death (HP:0001699)2.71921673
76Hypoalphalipoproteinemia (HP:0003233)2.70088705
77Abnormality of the intrinsic pathway (HP:0010989)2.68720869
78Abnormal finger flexion creases (HP:0006143)2.67314724
79Difficulty running (HP:0009046)2.66462724
80Progressive muscle weakness (HP:0003323)2.65588180
81Frequent falls (HP:0002359)2.64926548
82Hypoglycemic coma (HP:0001325)2.58908106
83Amyloidosis (HP:0011034)2.55055801
84Exercise intolerance (HP:0003546)2.54959884
85Hypercholesterolemia (HP:0003124)2.53874715
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51435999
87Cerebral hemorrhage (HP:0001342)2.51430435
88Increased intramyocellular lipid droplets (HP:0012240)2.49262602
89Abnormality of serum amino acid levels (HP:0003112)2.49175206
90Hyperbilirubinemia (HP:0002904)2.45541327
91Delayed CNS myelination (HP:0002188)2.45443347
92Hypophosphatemic rickets (HP:0004912)2.43638107
93EMG: neuropathic changes (HP:0003445)2.41148200
94Lethargy (HP:0001254)2.40335672
95Increased muscle lipid content (HP:0009058)2.37168112
96Fetal akinesia sequence (HP:0001989)2.36493748
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.35909712
98Dicarboxylic aciduria (HP:0003215)2.35909712
99Vascular calcification (HP:0004934)2.35874138
100Abnormal gallbladder physiology (HP:0012438)2.35333227
101Cholecystitis (HP:0001082)2.35333227
102Bulbar palsy (HP:0001283)2.34987861
103Ragged-red muscle fibers (HP:0003200)2.31550285
104Generalized muscle weakness (HP:0003324)2.31442730
105Abnormal gallbladder morphology (HP:0012437)2.29318920
106Abnormality of complement system (HP:0005339)2.29101372
107Acute encephalopathy (HP:0006846)2.27199164
108Ketoacidosis (HP:0001993)2.27188650
109Leukodystrophy (HP:0002415)2.26332329
110Bundle branch block (HP:0011710)2.26242814
111Metabolic acidosis (HP:0001942)2.25948733
112Abnormal mitochondria in muscle tissue (HP:0008316)2.22099465
113Limb-girdle muscle atrophy (HP:0003797)2.21325199
114Paraparesis (HP:0002385)2.20850542
115Dilated cardiomyopathy (HP:0001644)2.20631137
116Opisthotonus (HP:0002179)2.19096427
117Brushfield spots (HP:0001088)2.18038467
118Hepatocellular necrosis (HP:0001404)2.17916916
119Methylmalonic acidemia (HP:0002912)2.17235609
120Acute necrotizing encephalopathy (HP:0006965)2.16944731
121Weak cry (HP:0001612)2.14361690
122Mildly elevated creatine phosphokinase (HP:0008180)2.11998481
123Intention tremor (HP:0002080)2.10855342
124Gowers sign (HP:0003391)2.09941818
125Onion bulb formation (HP:0003383)2.09481844
126Axonal loss (HP:0003447)2.09477015
127Abnormality of the calcaneus (HP:0008364)2.07003766
128Irritability (HP:0000737)2.05706312
129Cardiovascular calcification (HP:0011915)2.05578283
130Mitochondrial inheritance (HP:0001427)2.03584014
131Cholelithiasis (HP:0001081)2.02535000
132Ventricular tachycardia (HP:0004756)2.02489430
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00145302
134Rickets (HP:0002748)1.99914348
135Spastic gait (HP:0002064)1.99819362
136Heart block (HP:0012722)1.97840746
137Slender build (HP:0001533)1.97620131
138Vomiting (HP:0002013)1.96364790
139Acanthocytosis (HP:0001927)1.95780842
140Spontaneous abortion (HP:0005268)1.94849533
141Abnormality of vitamin metabolism (HP:0100508)1.92905928
142Scapular winging (HP:0003691)1.92827774
143Congenital ichthyosiform erythroderma (HP:0007431)1.91272142
144Renal Fanconi syndrome (HP:0001994)1.91144355
145Abnormal atrioventricular conduction (HP:0005150)1.89240509
1463-Methylglutaconic aciduria (HP:0003535)1.88663342
147Autoamputation (HP:0001218)1.87222651
148Cerebral hypomyelination (HP:0006808)1.86558511
149Distal lower limb amyotrophy (HP:0008944)1.86169998
150Abnormality of the Achilles tendon (HP:0005109)1.85832754
151Cerebral palsy (HP:0100021)1.85283096
152Skin nodule (HP:0200036)1.84941832
153Pancreatitis (HP:0001733)1.84901427
154Methylmalonic aciduria (HP:0012120)1.84318823
155Fatigable weakness (HP:0003473)1.83150978
156Abnormality of the neuromuscular junction (HP:0003398)1.83150978
157Abnormality of urine glucose concentration (HP:0011016)1.81824420
158Glycosuria (HP:0003076)1.81824420
159Hepatic necrosis (HP:0002605)1.81303716
160Slow saccadic eye movements (HP:0000514)1.81117915
161Abnormality of pyrimidine metabolism (HP:0004353)1.80482222
162Increased CSF lactate (HP:0002490)1.79996309
163Stridor (HP:0010307)1.79889758
164Muscle fiber atrophy (HP:0100295)1.79771449
165Delayed myelination (HP:0012448)1.79757145
166Respiratory insufficiency due to muscle weakness (HP:0002747)1.78398565
167Spinal rigidity (HP:0003306)1.78296589
168Type 2 muscle fiber atrophy (HP:0003554)1.77662133
169Lactic acidosis (HP:0003128)1.77362878
170Difficulty climbing stairs (HP:0003551)1.76788395
171Peripheral hypomyelination (HP:0007182)1.76366430
172Spastic tetraparesis (HP:0001285)1.75405289
173Hepatosplenomegaly (HP:0001433)1.75307961
174Myocardial infarction (HP:0001658)1.75138630
175Hemorrhage of the eye (HP:0011885)1.74550771
176Abnormality of the gallbladder (HP:0005264)1.74534913
177Lipoatrophy (HP:0100578)1.74264219
178Progressive macrocephaly (HP:0004481)1.73701684
179Waddling gait (HP:0002515)1.73509899
180Gout (HP:0001997)1.72908060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.16003436
2PHKG15.82359728
3PHKG25.82359728
4TTN4.96368799
5OXSR14.28069243
6BCKDK4.21480853
7EPHB13.60206802
8BCR2.92467870
9PBK2.74638376
10PKN12.58875172
11MET2.57102281
12WNK42.50684700
13VRK22.40309561
14FGFR22.21221497
15CSNK1G32.15310472
16CDK192.03554126
17CSNK1A1L2.02335424
18ICK1.97614231
19MUSK1.84837262
20CSNK1G11.75302811
21MAPKAPK31.75290130
22LIMK11.71497760
23ERBB41.64442033
24NME11.62351678
25MAP2K31.59979558
26CSNK1G21.59352852
27MAP3K111.53047595
28MAPKAPK51.49255307
29CCNB11.46536037
30PRPF4B1.46486762
31WNK11.45525518
32TNIK1.43217530
33NME21.42560426
34SIK11.39936458
35NTRK11.38103363
36NEK61.37577215
37CAMK2B1.31924031
38NEK11.30021310
39MAPK151.28755283
40CAMK2G1.26289313
41FGFR41.22919475
42PIM21.16046157
43TESK21.15563378
44ROCK21.15427200
45CAMK2D1.15306386
46EEF2K1.12731308
47MAP2K61.09117022
48TRIB31.07528544
49UHMK11.07404863
50INSRR1.07047600
51MAP2K21.02013748
52EPHA41.00772032
53PDK20.99827499
54SGK4940.98358281
55SGK2230.98358281
56PRKCQ0.98109097
57ERN10.97702061
58PAK60.97543368
59PIK3CG0.96975398
60FGR0.96845621
61AKT20.92583425
62DYRK1B0.91820594
63MAPK110.91319824
64MARK10.89728718
65ABL20.88321669
66DYRK20.88124062
67PDPK10.82631456
68PAK30.81553494
69MST40.79601269
70TESK10.77977763
71PRKAA10.76066013
72OBSCN0.73273932
73TAOK20.72793043
74ARAF0.70309681
75CLK10.69605941
76IRAK20.68594266
77CAMK2A0.67966644
78PRKD30.67464110
79PRKD10.66953928
80MST1R0.66624326
81TYRO30.66189595
82KDR0.64830227
83TAOK30.64136950
84PNCK0.60197349
85GSK3A0.59931863
86CDK140.58987843
87SCYL20.58850416
88MOS0.55676831
89PIK3CA0.54156871
90PRKCZ0.53279056
91CAMK40.53073783
92IRAK30.52758148
93PINK10.50674665
94SMG10.49448245
95CSK0.48961700
96MAPK70.48519654
97PRKACB0.47131713
98CDK150.46277051
99VRK10.45713786
100PRKG10.45537808
101MARK20.45430993
102TRPM70.44947627
103FYN0.44898300
104TLK10.44151460
105CDK50.42747692
106IRAK10.42561442
107CSNK1D0.42177714
108PAK20.42044579
109PRKCE0.41326728
110CDK80.41061207
111DAPK10.40835070
112MAP3K130.40491489
113MAP2K40.40374641
114BRAF0.40357414
115GRK10.40201950
116CDK180.39359518
117CDK11A0.38656489
118DAPK30.37305752
119CAMK10.37213769
120BMPR1B0.36159460
121ITK0.35915585
122STK160.35882655
123DAPK20.35748046
124PDK10.35296970
125CSNK1A10.35228493
126MAPK120.34918587
127PRKAA20.34360233
128MAP2K70.34288238
129MAP3K10.33506669
130MAPK130.32155801
131TBK10.32033284
132KSR20.31795025
133RPS6KA50.31760113
134PRKACA0.31713394
135PRKCH0.31613148
136PRKACG0.30925697
137CASK0.29080510
138AURKA0.28816163
139ILK0.28438419
140MAPK40.28309966
141NEK90.27878115
142ERBB20.26821298
143ERBB30.26671825
144ABL10.26117817
145MAP3K70.25973614
146MAP2K10.25470151
147ROCK10.24869699
148RAF10.23781262
149RPS6KA30.20800993
150TNK20.20519776
151RPS6KB20.19978686
152GRK50.19426695
153RPS6KB10.17248666
154MAP4K20.17177868
155CSNK2A20.16727952
156ZAK0.16515819
157DMPK0.15682741
158LRRK20.15178151

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.66751095
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.26824179
3Steroid biosynthesis_Homo sapiens_hsa001003.19655628
4Fatty acid elongation_Homo sapiens_hsa000622.97688031
5Nitrogen metabolism_Homo sapiens_hsa009102.93994727
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.88040753
7* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.69984664
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55571582
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.52830006
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.52690534
11Butanoate metabolism_Homo sapiens_hsa006502.38942887
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.32049487
13Arginine biosynthesis_Homo sapiens_hsa002202.25587125
14Histidine metabolism_Homo sapiens_hsa003402.17647488
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15448204
16Complement and coagulation cascades_Homo sapiens_hsa046102.10170405
17Tryptophan metabolism_Homo sapiens_hsa003802.09648206
18Propanoate metabolism_Homo sapiens_hsa006402.08535851
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.07731904
20Fatty acid degradation_Homo sapiens_hsa000712.03332109
21Sulfur metabolism_Homo sapiens_hsa009202.01667599
22Peroxisome_Homo sapiens_hsa041461.98549370
23Fatty acid metabolism_Homo sapiens_hsa012121.86822084
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84353798
25Chemical carcinogenesis_Homo sapiens_hsa052041.82394677
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.81082417
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63401232
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.61572482
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59217004
30Folate biosynthesis_Homo sapiens_hsa007901.57145489
31beta-Alanine metabolism_Homo sapiens_hsa004101.50166000
32Retinol metabolism_Homo sapiens_hsa008301.47740979
33Fat digestion and absorption_Homo sapiens_hsa049751.47642808
34PPAR signaling pathway_Homo sapiens_hsa033201.46938861
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42645507
36Vitamin B6 metabolism_Homo sapiens_hsa007501.41805187
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41514848
38Dilated cardiomyopathy_Homo sapiens_hsa054141.37611712
39Pyruvate metabolism_Homo sapiens_hsa006201.37259166
40Tyrosine metabolism_Homo sapiens_hsa003501.25951635
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24462312
42Glucagon signaling pathway_Homo sapiens_hsa049221.23004516
43Staphylococcus aureus infection_Homo sapiens_hsa051501.21637861
44* Arginine and proline metabolism_Homo sapiens_hsa003301.19048174
45Caffeine metabolism_Homo sapiens_hsa002321.15259725
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.12324644
47Phenylalanine metabolism_Homo sapiens_hsa003601.12295551
48Bile secretion_Homo sapiens_hsa049761.10776823
49Glutathione metabolism_Homo sapiens_hsa004801.05658922
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.04888913
51Ether lipid metabolism_Homo sapiens_hsa005651.02515622
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99955658
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97500117
54Vitamin digestion and absorption_Homo sapiens_hsa049770.96206242
55Linoleic acid metabolism_Homo sapiens_hsa005910.95877191
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.94802379
57Selenocompound metabolism_Homo sapiens_hsa004500.94156944
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93883191
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92762622
60Protein export_Homo sapiens_hsa030600.91678310
61ABC transporters_Homo sapiens_hsa020100.91120722
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.90654892
63Glycerolipid metabolism_Homo sapiens_hsa005610.89647015
64Biosynthesis of amino acids_Homo sapiens_hsa012300.88247724
65Circadian rhythm_Homo sapiens_hsa047100.88176205
66Oxidative phosphorylation_Homo sapiens_hsa001900.87163142
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.85827331
68Starch and sucrose metabolism_Homo sapiens_hsa005000.84087510
69Carbon metabolism_Homo sapiens_hsa012000.81493450
70Galactose metabolism_Homo sapiens_hsa000520.78971967
71Sulfur relay system_Homo sapiens_hsa041220.73436372
72Insulin signaling pathway_Homo sapiens_hsa049100.73238175
73* Metabolic pathways_Homo sapiens_hsa011000.64649026
74Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64325099
75AMPK signaling pathway_Homo sapiens_hsa041520.63700517
76Insulin resistance_Homo sapiens_hsa049310.63082739
77Parkinsons disease_Homo sapiens_hsa050120.58122483
78Fatty acid biosynthesis_Homo sapiens_hsa000610.55075085
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54759830
80Calcium signaling pathway_Homo sapiens_hsa040200.51928664
81Alzheimers disease_Homo sapiens_hsa050100.49604227
82Pancreatic secretion_Homo sapiens_hsa049720.46208958
83Pyrimidine metabolism_Homo sapiens_hsa002400.44043997
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43329394
85Purine metabolism_Homo sapiens_hsa002300.40843943
86Base excision repair_Homo sapiens_hsa034100.39396149
87RNA polymerase_Homo sapiens_hsa030200.38033925
88Oxytocin signaling pathway_Homo sapiens_hsa049210.37064831
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.36934579
90Pentose phosphate pathway_Homo sapiens_hsa000300.35445932
91Proteasome_Homo sapiens_hsa030500.33470230
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33391230
93Arachidonic acid metabolism_Homo sapiens_hsa005900.33062341
94Ribosome_Homo sapiens_hsa030100.32127819
95Lysine degradation_Homo sapiens_hsa003100.31551062
96Prion diseases_Homo sapiens_hsa050200.28172985
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27712508
98Sphingolipid metabolism_Homo sapiens_hsa006000.24408645
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.22331452
100Protein digestion and absorption_Homo sapiens_hsa049740.22262743
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.21586665
102Axon guidance_Homo sapiens_hsa043600.16574611
103Ovarian steroidogenesis_Homo sapiens_hsa049130.14643350
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.14579289
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.12207632
106Insulin secretion_Homo sapiens_hsa049110.12020390
107Other glycan degradation_Homo sapiens_hsa005110.11019215
108Huntingtons disease_Homo sapiens_hsa050160.09965178
109DNA replication_Homo sapiens_hsa030300.06786377
110Regulation of autophagy_Homo sapiens_hsa041400.06006950
111Lysosome_Homo sapiens_hsa041420.04641570
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.03021721
113Fructose and mannose metabolism_Homo sapiens_hsa00051-0.1050896
114Tight junction_Homo sapiens_hsa04530-0.0927703
115Citrate cycle (TCA cycle)_Homo sapiens_hsa00020-0.0912259
116Malaria_Homo sapiens_hsa05144-0.0849523
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0689188
118SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0670491
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0588431
120GABAergic synapse_Homo sapiens_hsa04727-0.0536983
121Mineral absorption_Homo sapiens_hsa04978-0.0507243
122One carbon pool by folate_Homo sapiens_hsa00670-0.0420692
123Cardiac muscle contraction_Homo sapiens_hsa04260-0.0416773
124Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0232745
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0174360

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