GALNT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. This gene is expressed specifically in the brain, with highest expression in the cerebellum. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17889528
2synaptic vesicle exocytosis (GO:0016079)5.76579742
3vocalization behavior (GO:0071625)5.66157569
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.64803830
5synaptic vesicle maturation (GO:0016188)5.56974748
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.54945770
7locomotory exploration behavior (GO:0035641)5.41902650
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.39243026
9glutamate secretion (GO:0014047)5.37440400
10ionotropic glutamate receptor signaling pathway (GO:0035235)5.27551196
11regulation of synaptic vesicle exocytosis (GO:2000300)5.17048796
12synaptic vesicle docking involved in exocytosis (GO:0016081)5.10473071
13regulation of glutamate receptor signaling pathway (GO:1900449)5.03376980
14protein localization to synapse (GO:0035418)4.97411412
15neuronal action potential propagation (GO:0019227)4.91270132
16glutamate receptor signaling pathway (GO:0007215)4.77179663
17regulation of synaptic vesicle transport (GO:1902803)4.76596981
18neuron cell-cell adhesion (GO:0007158)4.60931015
19synaptic transmission, glutamatergic (GO:0035249)4.59306486
20regulation of neuronal synaptic plasticity (GO:0048168)4.52987889
21exploration behavior (GO:0035640)4.50088927
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.49180043
23neurotransmitter secretion (GO:0007269)4.39072462
24axon ensheathment in central nervous system (GO:0032291)4.26247344
25central nervous system myelination (GO:0022010)4.26247344
26neuron-neuron synaptic transmission (GO:0007270)4.22438970
27dendritic spine morphogenesis (GO:0060997)4.17090553
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15459646
29L-amino acid import (GO:0043092)4.15315314
30potassium ion import (GO:0010107)4.06684138
31neuron recognition (GO:0008038)4.05654347
32positive regulation of synapse maturation (GO:0090129)4.02140556
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01481246
34gamma-aminobutyric acid signaling pathway (GO:0007214)4.01194751
35layer formation in cerebral cortex (GO:0021819)3.99851393
36proline transport (GO:0015824)3.99349875
37long-term memory (GO:0007616)3.96969281
38cellular potassium ion homeostasis (GO:0030007)3.93554739
39synaptic vesicle endocytosis (GO:0048488)3.91814175
40axonal fasciculation (GO:0007413)3.88870751
41neuronal ion channel clustering (GO:0045161)3.88320425
42potassium ion homeostasis (GO:0055075)3.87769583
43positive regulation of membrane potential (GO:0045838)3.82235112
44regulation of postsynaptic membrane potential (GO:0060078)3.81813436
45regulation of synaptic plasticity (GO:0048167)3.81194365
46cerebellar Purkinje cell differentiation (GO:0021702)3.81178577
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79266042
48neurotransmitter-gated ion channel clustering (GO:0072578)3.79043856
49regulation of synapse structural plasticity (GO:0051823)3.78174767
50regulation of voltage-gated calcium channel activity (GO:1901385)3.75983192
51long-term synaptic potentiation (GO:0060291)3.68114733
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.60757579
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57753564
54neurotransmitter transport (GO:0006836)3.57674308
55regulation of vesicle fusion (GO:0031338)3.56324719
56regulation of dendritic spine morphogenesis (GO:0061001)3.55223124
57sodium ion export (GO:0071436)3.54818149
58amino acid import (GO:0043090)3.52808415
59regulation of neurotransmitter secretion (GO:0046928)3.50874855
60transmission of nerve impulse (GO:0019226)3.49474785
61neuromuscular synaptic transmission (GO:0007274)3.46519157
62dendritic spine organization (GO:0097061)3.44751659
63gamma-aminobutyric acid transport (GO:0015812)3.44745155
64postsynaptic membrane organization (GO:0001941)3.38796823
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37209339
66cellular sodium ion homeostasis (GO:0006883)3.34826647
67behavioral fear response (GO:0001662)3.32963117
68behavioral defense response (GO:0002209)3.32963117
69positive regulation of neurotransmitter secretion (GO:0001956)3.32921805
70innervation (GO:0060384)3.30999590
71membrane depolarization (GO:0051899)3.29798569
72regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.29749426
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29429772
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28454999
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.27745552
76regulation of neurotransmitter levels (GO:0001505)3.27327767
77G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26887456
78cell communication by electrical coupling (GO:0010644)3.24456935
79membrane depolarization during action potential (GO:0086010)3.22519367
80activation of protein kinase A activity (GO:0034199)3.22501449
81learning (GO:0007612)3.19917268
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.19214133
83long term synaptic depression (GO:0060292)3.18946785
84cerebellar granule cell differentiation (GO:0021707)3.18728909
85presynaptic membrane assembly (GO:0097105)3.17428374
86fear response (GO:0042596)3.17325831
87cell differentiation in hindbrain (GO:0021533)3.17101652
88neuromuscular process controlling balance (GO:0050885)3.16934818
89positive regulation of dendritic spine development (GO:0060999)3.15414027
90mechanosensory behavior (GO:0007638)3.15275500
91regulation of neurotransmitter transport (GO:0051588)3.11952631
92negative regulation of dendrite morphogenesis (GO:0050774)3.11362276
93neurotransmitter uptake (GO:0001504)3.11054433
94chemosensory behavior (GO:0007635)3.10876740
95positive regulation of dendritic spine morphogenesis (GO:0061003)3.09912612
96regulation of synaptic transmission (GO:0050804)3.09597918
97regulation of dendritic spine development (GO:0060998)3.08935280
98response to auditory stimulus (GO:0010996)3.08681484
99presynaptic membrane organization (GO:0097090)3.08148367
100response to histamine (GO:0034776)3.07416670
101neuromuscular process controlling posture (GO:0050884)3.06264880
102regulation of synapse maturation (GO:0090128)3.06088525
103intraspecies interaction between organisms (GO:0051703)3.05945115
104social behavior (GO:0035176)3.05945115
105synaptic transmission (GO:0007268)3.05301746
106neuromuscular process (GO:0050905)3.04339670
107serotonin metabolic process (GO:0042428)3.02375941
108adult walking behavior (GO:0007628)3.01949905
109dendrite morphogenesis (GO:0048813)3.01800924
110detection of calcium ion (GO:0005513)3.01705025
111positive regulation of synaptic transmission (GO:0050806)2.99192184
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99018251
113regulation of ARF protein signal transduction (GO:0032012)2.98450764
114positive regulation of synapse assembly (GO:0051965)2.97713672
115cell migration in hindbrain (GO:0021535)2.97484806
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.96991468
117positive regulation of neurotransmitter transport (GO:0051590)2.96171418
118signal release (GO:0023061)2.94918178
119vesicle transport along microtubule (GO:0047496)2.94733084
120establishment of synaptic vesicle localization (GO:0097480)2.94530970
121synaptic vesicle transport (GO:0048489)2.94530970
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93805601
123regulation of glutamate secretion (GO:0014048)2.91089395
124auditory behavior (GO:0031223)2.90135671
125synapse assembly (GO:0007416)2.89385001

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.71974951
2GBX2_23144817_ChIP-Seq_PC3_Human3.69722713
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.24596047
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.24074140
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.16802619
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.87061018
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83802556
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83802556
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76046905
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.75158216
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.65556453
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.58313631
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57377341
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.56447118
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.52117019
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49894259
17DROSHA_22980978_ChIP-Seq_HELA_Human2.49665577
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.40031797
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33634462
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.31549520
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31148515
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.29941689
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.26558713
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20297260
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.08107486
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88521471
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86837826
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82167514
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79997404
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.78049479
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76258773
32AR_21572438_ChIP-Seq_LNCaP_Human1.75540765
33SMAD4_21799915_ChIP-Seq_A2780_Human1.69355477
34TAF15_26573619_Chip-Seq_HEK293_Human1.68910316
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65718347
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58499068
37ZNF274_21170338_ChIP-Seq_K562_Hela1.49677419
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49530475
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.45024064
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43863296
41P300_19829295_ChIP-Seq_ESCs_Human1.43460900
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41725700
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36894836
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.36436749
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34694894
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31728604
47AR_25329375_ChIP-Seq_VCAP_Human1.30382199
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29641736
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28820947
50* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28028503
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.26746671
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.26625866
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.26587119
54CTCF_27219007_Chip-Seq_Bcells_Human1.26452064
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22303532
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.22236620
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21786067
58* AR_19668381_ChIP-Seq_PC3_Human1.20270045
59PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19840870
60TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16841112
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16380097
62STAT3_23295773_ChIP-Seq_U87_Human1.15377551
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14712331
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14512600
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.13711851
66* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12876495
67RNF2_27304074_Chip-Seq_NSC_Mouse1.12715562
68* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11827614
69* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11827614
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09043088
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08281865
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.07509129
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07444319
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06531727
75IGF1R_20145208_ChIP-Seq_DFB_Human1.04322320
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04193062
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.03938396
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03869034
79* TCF4_23295773_ChIP-Seq_U87_Human1.03723715
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.03626114
81* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03534491
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02235586
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00912592
84YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00877161
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00760659
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00731331
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.00347006
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.00285543
89ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99682180
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.99270238
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98505156
92* KDM2B_26808549_Chip-Seq_K562_Human0.98129996
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97154251
94* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96229608
95VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95975932
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.95253178
97OCT4_19829295_ChIP-Seq_ESCs_Human0.94355806
98RUNX2_22187159_ChIP-Seq_PCA_Human0.93488750
99FUS_26573619_Chip-Seq_HEK293_Human0.93437286
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92319578
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90943976
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90610537
103TP53_16413492_ChIP-PET_HCT116_Human0.90423541
104JUN_21703547_ChIP-Seq_K562_Human0.90328420
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90206252
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89656582
107AHR_22903824_ChIP-Seq_MCF-7_Human0.89359238
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89349435
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.89334891
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89282028
111TP53_18474530_ChIP-ChIP_U2OS_Human0.89096016
112* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88508113
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87836595
114TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87314746
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.86264540
116KLF4_19829295_ChIP-Seq_ESCs_Human0.85814476
117VDR_22108803_ChIP-Seq_LS180_Human0.85649235
118* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83637241
119FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81628391
120TP53_20018659_ChIP-ChIP_R1E_Mouse0.80868766
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79761231
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.77518449
123SMAD4_21741376_ChIP-Seq_ESCs_Human0.76620433
124DPY_21335234_ChIP-Seq_ESCs_Mouse0.73616178
125SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73396478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.96377067
2MP0003880_abnormal_central_pattern5.48856010
3MP0003635_abnormal_synaptic_transmissio4.32722233
4MP0004270_analgesia3.77517046
5MP0002063_abnormal_learning/memory/cond3.56187074
6MP0009745_abnormal_behavioral_response3.46373731
7MP0002064_seizures3.25079943
8MP0001968_abnormal_touch/_nociception3.22369744
9MP0009046_muscle_twitch2.98192188
10MP0002572_abnormal_emotion/affect_behav2.92773261
11MP0002736_abnormal_nociception_after2.69734897
12MP0002272_abnormal_nervous_system2.68717675
13MP0002734_abnormal_mechanical_nocicepti2.68063862
14MP0001501_abnormal_sleep_pattern2.53493836
15MP0005423_abnormal_somatic_nervous2.52872486
16MP0002735_abnormal_chemical_nociception2.51807655
17MP0001486_abnormal_startle_reflex2.50273682
18MP0001440_abnormal_grooming_behavior2.46869303
19MP0006276_abnormal_autonomic_nervous2.06315258
20MP0002067_abnormal_sensory_capabilities2.05771865
21MP0002733_abnormal_thermal_nociception2.04657271
22MP0003329_amyloid_beta_deposits2.04452951
23MP0001970_abnormal_pain_threshold2.00835107
24MP0008569_lethality_at_weaning1.98564882
25MP0000778_abnormal_nervous_system1.97398004
26MP0002184_abnormal_innervation1.91466734
27MP0004811_abnormal_neuron_physiology1.79581954
28MP0002557_abnormal_social/conspecific_i1.76046471
29MP0004858_abnormal_nervous_system1.72585046
30MP0003123_paternal_imprinting1.71490051
31MP0009780_abnormal_chondrocyte_physiolo1.62259308
32MP0001984_abnormal_olfaction1.61934511
33MP0005386_behavior/neurological_phenoty1.60317407
34MP0004924_abnormal_behavior1.60317407
35MP0005645_abnormal_hypothalamus_physiol1.59495749
36MP0003122_maternal_imprinting1.58843711
37MP0003879_abnormal_hair_cell1.57148690
38MP0000955_abnormal_spinal_cord1.56411015
39MP0002909_abnormal_adrenal_gland1.54007641
40MP0001502_abnormal_circadian_rhythm1.45436080
41MP0002066_abnormal_motor_capabilities/c1.43811650
42MP0003787_abnormal_imprinting1.42861671
43MP0002882_abnormal_neuron_morphology1.42479606
44MP0004142_abnormal_muscle_tone1.35048709
45MP0002822_catalepsy1.33132401
46MP0008877_abnormal_DNA_methylation1.32601921
47MP0001529_abnormal_vocalization1.30220177
48MP0005646_abnormal_pituitary_gland1.29979382
49MP0003633_abnormal_nervous_system1.28682981
50MP0002837_dystrophic_cardiac_calcinosis1.28151886
51MP0004145_abnormal_muscle_electrophysio1.25603735
52MP0001905_abnormal_dopamine_level1.14276876
53MP0010386_abnormal_urinary_bladder1.13727553
54MP0004885_abnormal_endolymph1.12134902
55MP0003631_nervous_system_phenotype1.11657078
56MP0008961_abnormal_basal_metabolism1.11398507
57MP0001986_abnormal_taste_sensitivity1.10562174
58MP0002152_abnormal_brain_morphology1.10291577
59MP0000604_amyloidosis1.01271572
60MP0000751_myopathy1.00173221
61MP0008872_abnormal_physiological_respon0.97914446
62MP0004510_myositis0.97326657
63MP0005535_abnormal_body_temperature0.96157562
64MP0004147_increased_porphyrin_level0.96042375
65MP0000569_abnormal_digit_pigmentation0.95762398
66MP0002653_abnormal_ependyma_morphology0.95469417
67MP0002069_abnormal_eating/drinking_beha0.95282303
68MP0004742_abnormal_vestibular_system0.94258982
69MP0002229_neurodegeneration0.88344955
70MP0001188_hyperpigmentation0.85422763
71MP0003075_altered_response_to0.84397490
72MP0005167_abnormal_blood-brain_barrier0.84212873
73MP0002876_abnormal_thyroid_physiology0.83770842
74MP0001963_abnormal_hearing_physiology0.82780655
75MP0008874_decreased_physiological_sensi0.82651660
76MP0003632_abnormal_nervous_system0.80737182
77MP0005551_abnormal_eye_electrophysiolog0.77618927
78MP0004484_altered_response_of0.77180495
79MP0005499_abnormal_olfactory_system0.74958919
80MP0005394_taste/olfaction_phenotype0.74958919
81MP0004085_abnormal_heartbeat0.73566832
82MP0003634_abnormal_glial_cell0.72564314
83MP0002752_abnormal_somatic_nervous0.71697732
84MP0000920_abnormal_myelination0.69213034
85MP0001177_atelectasis0.68927063
86MP0001348_abnormal_lacrimal_gland0.66387587
87MP0004043_abnormal_pH_regulation0.66144874
88MP0000026_abnormal_inner_ear0.65836386
89MP0003690_abnormal_glial_cell0.65095507
90MP0002638_abnormal_pupillary_reflex0.64707136
91MP0004215_abnormal_myocardial_fiber0.63920053
92MP0000013_abnormal_adipose_tissue0.63556359
93MP0004133_heterotaxia0.63175344
94MP0006292_abnormal_olfactory_placode0.61764712
95MP0000631_abnormal_neuroendocrine_gland0.60861131
96MP0004130_abnormal_muscle_cell0.60172122
97MP0002090_abnormal_vision0.59098780
98MP0003121_genomic_imprinting0.57400208
99MP0001664_abnormal_digestion0.56516121
100MP0003861_abnormal_nervous_system0.55305768
101MP0001346_abnormal_lacrimal_gland0.54454239
102MP0005187_abnormal_penis_morphology0.54208313
103MP0003137_abnormal_impulse_conducting0.52944652
104MP0003283_abnormal_digestive_organ0.52410762
105MP0001943_abnormal_respiration0.51953765
106MP0003938_abnormal_ear_development0.51871064
107MP0010769_abnormal_survival0.51785484
108MP0005623_abnormal_meninges_morphology0.51534659
109MP0010770_preweaning_lethality0.49598254
110MP0002082_postnatal_lethality0.49598254
111MP0001485_abnormal_pinna_reflex0.49518096
112MP0001299_abnormal_eye_distance/0.49093757
113MP0003172_abnormal_lysosome_physiology0.49007102
114MP0010768_mortality/aging0.48887889
115MP0000579_abnormal_nail_morphology0.48779589
116MP0003956_abnormal_body_size0.45754771

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.04409629
2Myokymia (HP:0002411)6.83153095
3Focal seizures (HP:0007359)6.10000965
4Visual hallucinations (HP:0002367)5.66249646
5Epileptic encephalopathy (HP:0200134)5.25086685
6Atonic seizures (HP:0010819)5.18025665
7Febrile seizures (HP:0002373)5.06911218
8Progressive cerebellar ataxia (HP:0002073)4.89815957
9Absence seizures (HP:0002121)4.54745945
10Dialeptic seizures (HP:0011146)4.18149972
11Action tremor (HP:0002345)4.10532640
12Supranuclear gaze palsy (HP:0000605)4.08085977
13Generalized tonic-clonic seizures (HP:0002069)4.03576752
14Broad-based gait (HP:0002136)3.78037459
15Cerebral hypomyelination (HP:0006808)3.66347044
16Amblyopia (HP:0000646)3.59710202
17Gaze-evoked nystagmus (HP:0000640)3.45125205
18Impaired vibration sensation in the lower limbs (HP:0002166)3.42975043
19Hyperventilation (HP:0002883)3.39319063
20Abnormal eating behavior (HP:0100738)3.38032790
21Dysmetria (HP:0001310)3.28500902
22Poor eye contact (HP:0000817)3.20761452
23Dysdiadochokinesis (HP:0002075)3.17758445
24Truncal ataxia (HP:0002078)3.14699686
25Depression (HP:0000716)3.11832756
26Impaired smooth pursuit (HP:0007772)3.09624025
27Diplopia (HP:0000651)3.04607879
28Abnormality of binocular vision (HP:0011514)3.04607879
29Cerebral inclusion bodies (HP:0100314)3.04292793
30Urinary bladder sphincter dysfunction (HP:0002839)3.04143387
31Ankle clonus (HP:0011448)3.00822515
32Genetic anticipation (HP:0003743)2.99774965
33Postural instability (HP:0002172)2.92328302
34Anxiety (HP:0000739)2.91783110
35Abnormality of the lower motor neuron (HP:0002366)2.89530874
36Mutism (HP:0002300)2.87924129
37Akinesia (HP:0002304)2.87120394
38Hemiparesis (HP:0001269)2.87037425
39Impaired social interactions (HP:0000735)2.85861008
40Abnormal social behavior (HP:0012433)2.85861008
41Polyphagia (HP:0002591)2.84223934
42Drooling (HP:0002307)2.84220169
43Excessive salivation (HP:0003781)2.84220169
44Neurofibrillary tangles (HP:0002185)2.83783079
45Epileptiform EEG discharges (HP:0011182)2.71860057
46Urinary urgency (HP:0000012)2.69391621
47Papilledema (HP:0001085)2.69287758
48Scanning speech (HP:0002168)2.61687775
49Abnormality of ocular smooth pursuit (HP:0000617)2.60206671
50Spastic tetraparesis (HP:0001285)2.58031772
51Spastic gait (HP:0002064)2.52964790
52Bradykinesia (HP:0002067)2.52250107
53EEG with generalized epileptiform discharges (HP:0011198)2.48927649
54Stereotypic behavior (HP:0000733)2.46405640
55Absent speech (HP:0001344)2.42745223
56Ventricular fibrillation (HP:0001663)2.39232972
57Tetraplegia (HP:0002445)2.39119458
58Failure to thrive in infancy (HP:0001531)2.37047965
59Fetal akinesia sequence (HP:0001989)2.36871759
60Progressive inability to walk (HP:0002505)2.36671676
61Clonus (HP:0002169)2.36462784
62Delusions (HP:0000746)2.36443025
63Morphological abnormality of the pyramidal tract (HP:0002062)2.36247616
64CNS hypomyelination (HP:0003429)2.34165299
65Dysmetric saccades (HP:0000641)2.33217648
66Intention tremor (HP:0002080)2.33018242
67Hypsarrhythmia (HP:0002521)2.29562069
68Hemiplegia (HP:0002301)2.28805448
69Status epilepticus (HP:0002133)2.25916335
70Impaired vibratory sensation (HP:0002495)2.25595550
71Thickened helices (HP:0000391)2.22022686
72Abnormality of the corticospinal tract (HP:0002492)2.21921457
73Torticollis (HP:0000473)2.20767315
74Insidious onset (HP:0003587)2.18925256
75Termporal pattern (HP:0011008)2.18925256
76Focal dystonia (HP:0004373)2.17259409
77Protruding tongue (HP:0010808)2.13156886
78Amyotrophic lateral sclerosis (HP:0007354)2.11104933
79Pheochromocytoma (HP:0002666)2.10288908
80Lower limb muscle weakness (HP:0007340)2.08998240
81Inability to walk (HP:0002540)2.07978959
82Rigidity (HP:0002063)2.04910453
83Dyskinesia (HP:0100660)2.04049339
84Gait ataxia (HP:0002066)2.03988405
85Generalized myoclonic seizures (HP:0002123)2.03726579
86Psychosis (HP:0000709)2.01601788
87Sleep apnea (HP:0010535)1.98192032
88Choreoathetosis (HP:0001266)1.97842529
89Hypoventilation (HP:0002791)1.95431690
90Prolonged QT interval (HP:0001657)1.95045895
91Incomplete penetrance (HP:0003829)1.94007051
92Agitation (HP:0000713)1.91584594
93Abnormality of salivation (HP:0100755)1.90362309
94Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90255449
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.90255449
96Abnormal ciliary motility (HP:0012262)1.90112648
97Apathy (HP:0000741)1.89924581
98Peripheral hypomyelination (HP:0007182)1.89911052
99Inappropriate behavior (HP:0000719)1.89124647
100Spastic tetraplegia (HP:0002510)1.88963348
101Insomnia (HP:0100785)1.88241406
102Esotropia (HP:0000565)1.87302264
103Lower limb asymmetry (HP:0100559)1.86882881
104Increased circulating renin level (HP:0000848)1.86159284
105Specific learning disability (HP:0001328)1.86068089
106Neuronal loss in central nervous system (HP:0002529)1.85478419
107Pointed chin (HP:0000307)1.84113625
108Blue irides (HP:0000635)1.82775426
109Abnormality of the labia minora (HP:0012880)1.82608965
110Craniofacial dystonia (HP:0012179)1.82003893
111Megalencephaly (HP:0001355)1.80447815
112Rapidly progressive (HP:0003678)1.80397546
113Annular pancreas (HP:0001734)1.80147953
114Neuroendocrine neoplasm (HP:0100634)1.79830938
115Abnormal EKG (HP:0003115)1.79096232
116Abnormality of saccadic eye movements (HP:0000570)1.78338596
117Gait imbalance (HP:0002141)1.77762227
118Congenital stationary night blindness (HP:0007642)1.74957922
119Confusion (HP:0001289)1.72891592
120Unsteady gait (HP:0002317)1.72422526
121Limb dystonia (HP:0002451)1.71888882
122Obstructive sleep apnea (HP:0002870)1.71827548
123Diminished motivation (HP:0000745)1.71285688
124Retinal dysplasia (HP:0007973)1.70947286

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.42155469
2MAP3K94.25558150
3EPHA44.25536760
4MAP3K43.10453076
5RIPK43.03405023
6MINK12.81067504
7MARK12.67643247
8MAP2K72.67319137
9DAPK22.53989873
10MAP3K122.50265083
11PAK62.37807844
12CASK2.08309834
13MAP2K42.07644911
14NTRK21.92896876
15CDK191.87409679
16KSR21.86424008
17PNCK1.82034349
18PLK21.81760209
19DAPK11.79994628
20KSR11.79635113
21GRK51.63368872
22PRKD31.61958236
23SIK21.58171197
24CAMKK11.57663826
25NTRK11.56179633
26CDK51.50922539
27PRPF4B1.39159306
28MAP3K131.38818112
29BMPR21.34890943
30ARAF1.31763993
31MAPK131.30418689
32PRKCG1.29555891
33TNIK1.27990580
34STK381.27801100
35UHMK11.21650337
36EPHB11.20421068
37TYRO31.12497793
38FES1.10073653
39CAMK2A1.06949473
40PTK2B1.04491289
41PKN10.97163762
42CDK180.95661502
43CAMK10.94340423
44NME10.93348130
45CAMKK20.92596578
46MAP3K20.92439718
47CDK150.92062319
48LATS20.91869079
49CAMK2B0.91326968
50CDK140.87197652
51OXSR10.84996446
52STK110.81255432
53WNK40.80707693
54CDK11A0.80385099
55DYRK1A0.78244570
56SGK4940.77259586
57SGK2230.77259586
58RAF10.76429120
59BRSK10.76304667
60PAK30.74637215
61WNK10.72961569
62PHKG20.68269445
63PHKG10.68269445
64SIK30.68120279
65FGR0.67842760
66RET0.67584186
67PRKCH0.65478301
68MAPK120.65288615
69SGK10.63679349
70RIPK10.62148116
71SGK20.62009328
72PDK10.61471347
73MAP2K20.58665226
74TAOK10.58656848
75PINK10.55035636
76TNK20.54436865
77CAMK1G0.53491421
78TRIM280.52308750
79FGFR20.52005171
80MAP3K60.51684624
81FER0.51497001
82LIMK10.51154946
83MAP3K70.50867814
84DYRK20.49244933
85PDPK10.49172156
86CSNK1G20.48541761
87MARK20.48080544
88SGK30.47664235
89BCR0.46318294
90PRKCE0.45645743
91CAMK2D0.45522396
92SCYL20.45346711
93PRKCZ0.45320401
94MAP2K60.43746299
95CAMK2G0.43229302
96ERBB20.43140519
97FYN0.42813632
98MAP3K10.42125219
99PRKCA0.41690073
100RPS6KA30.41662065
101DAPK30.40588472
102ROCK20.40579023
103RPS6KA20.40129683
104ALK0.39869593
105MAPK100.39700608
106GRK70.39515434
107PRKACA0.39182624
108PRKG10.36895242
109ADRBK20.36749470
110CAMK40.36367376
111MOS0.35755356
112LMTK20.35422327
113MAP2K10.35148580
114MAP3K110.34763585
115GRK10.33790851
116CDC42BPA0.33597427
117NEK60.32962896
118BRAF0.31882642
119MAPKAPK50.31514080
120WNK30.31485334
121DMPK0.31308439
122CSNK1E0.30986445
123INSRR0.30862461
124AKT30.30767546

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.20853791
2Synaptic vesicle cycle_Homo sapiens_hsa047213.42814276
3Long-term potentiation_Homo sapiens_hsa047202.95632914
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82752240
5Circadian entrainment_Homo sapiens_hsa047132.76438469
6Glutamatergic synapse_Homo sapiens_hsa047242.65821036
7GABAergic synapse_Homo sapiens_hsa047272.53837825
8Amphetamine addiction_Homo sapiens_hsa050312.50923728
9Olfactory transduction_Homo sapiens_hsa047402.48775465
10Morphine addiction_Homo sapiens_hsa050322.44348275
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29316544
12Salivary secretion_Homo sapiens_hsa049702.27484327
13Dopaminergic synapse_Homo sapiens_hsa047282.13567494
14Insulin secretion_Homo sapiens_hsa049112.01768934
15Gastric acid secretion_Homo sapiens_hsa049711.89257228
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86952367
17Collecting duct acid secretion_Homo sapiens_hsa049661.86423877
18Taste transduction_Homo sapiens_hsa047421.86174268
19Long-term depression_Homo sapiens_hsa047301.78630426
20Cholinergic synapse_Homo sapiens_hsa047251.77116690
21Calcium signaling pathway_Homo sapiens_hsa040201.68554658
22Oxytocin signaling pathway_Homo sapiens_hsa049211.67665892
23Renin secretion_Homo sapiens_hsa049241.67520761
24Serotonergic synapse_Homo sapiens_hsa047261.65987180
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62049279
26Vitamin B6 metabolism_Homo sapiens_hsa007501.55069914
27GnRH signaling pathway_Homo sapiens_hsa049121.47935092
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36527091
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36063363
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36039263
31Cocaine addiction_Homo sapiens_hsa050301.33621040
32Gap junction_Homo sapiens_hsa045401.30682638
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25672990
34cAMP signaling pathway_Homo sapiens_hsa040241.25314530
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20760850
36Axon guidance_Homo sapiens_hsa043601.17766656
37Type II diabetes mellitus_Homo sapiens_hsa049301.14395587
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14394710
39Estrogen signaling pathway_Homo sapiens_hsa049151.13587031
40Vibrio cholerae infection_Homo sapiens_hsa051101.11023880
41Glioma_Homo sapiens_hsa052141.10773323
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08866318
43Cardiac muscle contraction_Homo sapiens_hsa042601.05525750
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03229592
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02905113
46ErbB signaling pathway_Homo sapiens_hsa040121.02648516
47Melanogenesis_Homo sapiens_hsa049161.02531593
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.98370698
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93937151
50Oocyte meiosis_Homo sapiens_hsa041140.91353428
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90081011
52Pancreatic secretion_Homo sapiens_hsa049720.89031765
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.88852567
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80852134
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.77659935
56Choline metabolism in cancer_Homo sapiens_hsa052310.75809010
57Thyroid hormone synthesis_Homo sapiens_hsa049180.74154755
58VEGF signaling pathway_Homo sapiens_hsa043700.74122392
59Phototransduction_Homo sapiens_hsa047440.73692234
60MAPK signaling pathway_Homo sapiens_hsa040100.70543199
61Dorso-ventral axis formation_Homo sapiens_hsa043200.69113054
62Mineral absorption_Homo sapiens_hsa049780.64168850
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.64011959
64Alzheimers disease_Homo sapiens_hsa050100.63623778
65Dilated cardiomyopathy_Homo sapiens_hsa054140.61525727
66Inositol phosphate metabolism_Homo sapiens_hsa005620.60031217
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55879763
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55870143
69Ras signaling pathway_Homo sapiens_hsa040140.55476938
70Glucagon signaling pathway_Homo sapiens_hsa049220.55102253
71Ether lipid metabolism_Homo sapiens_hsa005650.53998633
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.53926415
73Rap1 signaling pathway_Homo sapiens_hsa040150.52152835
74Circadian rhythm_Homo sapiens_hsa047100.52063665
75African trypanosomiasis_Homo sapiens_hsa051430.51706435
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50889281
77Arginine and proline metabolism_Homo sapiens_hsa003300.48838867
78Parkinsons disease_Homo sapiens_hsa050120.48579506
79Endocytosis_Homo sapiens_hsa041440.46218700
80Oxidative phosphorylation_Homo sapiens_hsa001900.44588867
81mTOR signaling pathway_Homo sapiens_hsa041500.44095920
82Wnt signaling pathway_Homo sapiens_hsa043100.42935767
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42651797
84Ovarian steroidogenesis_Homo sapiens_hsa049130.41905353
85Type I diabetes mellitus_Homo sapiens_hsa049400.41180399
86Linoleic acid metabolism_Homo sapiens_hsa005910.41069680
87Histidine metabolism_Homo sapiens_hsa003400.40287946
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40129956
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40070005
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38658739
91Nitrogen metabolism_Homo sapiens_hsa009100.38438730
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38117634
93Rheumatoid arthritis_Homo sapiens_hsa053230.37668071
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37376319
95Alcoholism_Homo sapiens_hsa050340.36374078
96Renal cell carcinoma_Homo sapiens_hsa052110.36159272
97Prion diseases_Homo sapiens_hsa050200.35915919
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35178332
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33934246
100Non-small cell lung cancer_Homo sapiens_hsa052230.31771100
101Bile secretion_Homo sapiens_hsa049760.31764822
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31624033
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30648915
104Butanoate metabolism_Homo sapiens_hsa006500.30473596
105Chemokine signaling pathway_Homo sapiens_hsa040620.30057314
106Arginine biosynthesis_Homo sapiens_hsa002200.29471279
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.29320435
108Endometrial cancer_Homo sapiens_hsa052130.29224188
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29196313
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27568051
111Insulin signaling pathway_Homo sapiens_hsa049100.26947663
112Salmonella infection_Homo sapiens_hsa051320.26908572
113Phagosome_Homo sapiens_hsa041450.26880958
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25980295
115beta-Alanine metabolism_Homo sapiens_hsa004100.24422288
116Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24003904
117Regulation of autophagy_Homo sapiens_hsa041400.23319989
118Fatty acid biosynthesis_Homo sapiens_hsa000610.18718438
119Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.17013782
120Huntingtons disease_Homo sapiens_hsa050160.16203631

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »