GALNT8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.84991288
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39950731
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.20846579
4postsynaptic membrane organization (GO:0001941)5.04483539
5glutamate secretion (GO:0014047)5.03628389
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.02567536
7synaptic vesicle exocytosis (GO:0016079)4.86777925
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.86341776
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.79629821
10protein localization to synapse (GO:0035418)4.72361304
11neuron cell-cell adhesion (GO:0007158)4.61558134
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.58717901
13regulation of synaptic vesicle exocytosis (GO:2000300)4.53791102
14vocalization behavior (GO:0071625)4.50607086
15neurotransmitter-gated ion channel clustering (GO:0072578)4.36896615
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34715753
17dendritic spine morphogenesis (GO:0060997)4.29687960
18neurotransmitter secretion (GO:0007269)4.28820614
19synaptic transmission, glutamatergic (GO:0035249)4.15424314
20presynaptic membrane assembly (GO:0097105)4.15179701
21locomotory exploration behavior (GO:0035641)4.04205824
22presynaptic membrane organization (GO:0097090)4.00681045
23regulation of synaptic vesicle transport (GO:1902803)3.94543066
24cellular potassium ion homeostasis (GO:0030007)3.93597668
25exploration behavior (GO:0035640)3.89933357
26positive regulation of synapse maturation (GO:0090129)3.82865494
27pyrimidine nucleobase catabolic process (GO:0006208)3.82774223
28glutamate receptor signaling pathway (GO:0007215)3.82040259
29transmission of nerve impulse (GO:0019226)3.77388473
30regulation of glutamate receptor signaling pathway (GO:1900449)3.76836994
31regulation of neuronal synaptic plasticity (GO:0048168)3.75947376
32auditory behavior (GO:0031223)3.73219492
33neuron-neuron synaptic transmission (GO:0007270)3.70924654
34neuron recognition (GO:0008038)3.69929308
35nucleobase catabolic process (GO:0046113)3.65546413
36cerebellar granule cell differentiation (GO:0021707)3.63869337
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.62494145
38regulation of synapse structural plasticity (GO:0051823)3.62452751
39neuronal action potential propagation (GO:0019227)3.62235425
40membrane depolarization during action potential (GO:0086010)3.58403035
41layer formation in cerebral cortex (GO:0021819)3.57516534
42neuronal ion channel clustering (GO:0045161)3.57391105
43central nervous system myelination (GO:0022010)3.56303923
44axon ensheathment in central nervous system (GO:0032291)3.56303923
45axonal fasciculation (GO:0007413)3.52720915
46regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.50630768
47positive regulation of membrane potential (GO:0045838)3.44750533
48neurotransmitter transport (GO:0006836)3.41051489
49positive regulation of dendritic spine development (GO:0060999)3.38724279
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.36565907
51sodium ion export (GO:0071436)3.35501855
52regulation of long-term neuronal synaptic plasticity (GO:0048169)3.35026264
53gamma-aminobutyric acid transport (GO:0015812)3.32972511
54establishment of mitochondrion localization (GO:0051654)3.29529429
55regulation of postsynaptic membrane potential (GO:0060078)3.28369755
56regulation of synapse maturation (GO:0090128)3.27142008
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25949269
58mechanosensory behavior (GO:0007638)3.23554343
59regulation of neurotransmitter levels (GO:0001505)3.22855498
60regulation of neurotransmitter secretion (GO:0046928)3.21875961
61gamma-aminobutyric acid signaling pathway (GO:0007214)3.19648687
62positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.19254945
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.18004946
64membrane depolarization (GO:0051899)3.15648765
65response to auditory stimulus (GO:0010996)3.13606193
66neuromuscular synaptic transmission (GO:0007274)3.11742133
67synapse assembly (GO:0007416)3.10033883
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08918830
69detection of calcium ion (GO:0005513)3.08745349
70dendritic spine organization (GO:0097061)3.06758067
71regulation of neurotransmitter transport (GO:0051588)3.06624009
72cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05882888
73behavioral response to nicotine (GO:0035095)3.03085091
74L-amino acid import (GO:0043092)3.01944435
75adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01710571
76regulation of dendritic spine morphogenesis (GO:0061001)3.00423910
77regulation of vesicle fusion (GO:0031338)3.00413188
78positive regulation of neurotransmitter transport (GO:0051590)3.00394569
79synaptic vesicle endocytosis (GO:0048488)3.00019834
80adult walking behavior (GO:0007628)2.95154834
81cerebellar Purkinje cell differentiation (GO:0021702)2.94415567
82potassium ion import (GO:0010107)2.92011580
83central nervous system projection neuron axonogenesis (GO:0021952)2.91980912
84startle response (GO:0001964)2.90877606
85potassium ion homeostasis (GO:0055075)2.88919345
86regulation of synaptic plasticity (GO:0048167)2.87646602
87regulation of synaptic transmission, glutamatergic (GO:0051966)2.86863708
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.86122262
89establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85681089
90mitochondrion transport along microtubule (GO:0047497)2.85681089
91positive regulation of neurotransmitter secretion (GO:0001956)2.85492297
92positive regulation of synapse assembly (GO:0051965)2.84481670
93regulation of dendritic spine development (GO:0060998)2.83701911
94synaptic transmission (GO:0007268)2.83383350
95calcium ion-dependent exocytosis (GO:0017156)2.81596945
96regulation of calcium ion-dependent exocytosis (GO:0017158)2.80084212
97synapse organization (GO:0050808)2.79958490
98regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78039206
99cerebral cortex neuron differentiation (GO:0021895)2.77567654
100neuronal action potential (GO:0019228)2.77265074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.61522214
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.07929187
3GBX2_23144817_ChIP-Seq_PC3_Human3.02311952
4REST_21632747_ChIP-Seq_MESCs_Mouse2.98875418
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.76090547
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.71938702
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.55201840
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47511436
9DROSHA_22980978_ChIP-Seq_HELA_Human2.41467570
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.35562008
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28856639
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28674684
13SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26692896
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.25010515
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21528134
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21528134
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17965796
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.17164113
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.11051967
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10570406
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07145392
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06982048
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05880488
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02890688
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02702364
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.95536577
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.84709211
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80168048
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78434365
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77675798
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66465854
32TAF15_26573619_Chip-Seq_HEK293_Human1.66437288
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63846200
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.62194069
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61100812
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58001197
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57753539
38RNF2_27304074_Chip-Seq_NSC_Mouse1.56839082
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52648624
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51111108
41SMAD4_21799915_ChIP-Seq_A2780_Human1.46480430
42AR_21572438_ChIP-Seq_LNCaP_Human1.46291234
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46165154
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42753535
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42753535
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.41060059
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31824758
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31358131
49IGF1R_20145208_ChIP-Seq_DFB_Human1.30741554
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30549808
51P300_19829295_ChIP-Seq_ESCs_Human1.29602407
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27839413
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.27522679
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26991502
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21555633
56FUS_26573619_Chip-Seq_HEK293_Human1.21021548
57AR_25329375_ChIP-Seq_VCAP_Human1.20866451
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19454769
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15794557
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15726583
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.15278127
62AR_19668381_ChIP-Seq_PC3_Human1.14276205
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13823689
64STAT3_23295773_ChIP-Seq_U87_Human1.13205818
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.10256321
66* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10089697
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08190258
68SMAD3_21741376_ChIP-Seq_ESCs_Human1.08061494
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06578711
70TCF4_23295773_ChIP-Seq_U87_Human1.06411567
71VDR_22108803_ChIP-Seq_LS180_Human1.06387579
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05920473
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05763161
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.05747098
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03487512
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03311700
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02642236
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00463026
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00063935
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99573734
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99175322
82CTCF_27219007_Chip-Seq_Bcells_Human0.97175637
83RUNX2_22187159_ChIP-Seq_PCA_Human0.96980537
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.94783335
85CBP_20019798_ChIP-Seq_JUKART_Human0.93590800
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93590800
87NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92478139
88ZNF274_21170338_ChIP-Seq_K562_Hela0.91969734
89* PRDM14_20953172_ChIP-Seq_ESCs_Human0.91134810
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90977688
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90435194
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89811227
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.89063013
94KDM2B_26808549_Chip-Seq_REH_Human0.88999381
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.88342792
96BCAT_22108803_ChIP-Seq_LS180_Human0.88174788
97CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88157798
98YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86426318
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86135562
100SOX9_26525672_Chip-Seq_HEART_Mouse0.83651771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25234429
2MP0003880_abnormal_central_pattern4.41434372
3MP0004270_analgesia3.94759405
4MP0003635_abnormal_synaptic_transmissio3.43170449
5MP0005423_abnormal_somatic_nervous3.14400955
6MP0003787_abnormal_imprinting2.89507655
7MP0002064_seizures2.86284360
8MP0009745_abnormal_behavioral_response2.82673499
9MP0002734_abnormal_mechanical_nocicepti2.79778634
10MP0002063_abnormal_learning/memory/cond2.78677171
11MP0002272_abnormal_nervous_system2.74818031
12MP0001968_abnormal_touch/_nociception2.66753117
13MP0009046_muscle_twitch2.64835822
14MP0002735_abnormal_chemical_nociception2.50850525
15MP0001486_abnormal_startle_reflex2.47355273
16MP0002572_abnormal_emotion/affect_behav2.46048249
17MP0000778_abnormal_nervous_system2.42244666
18MP0003122_maternal_imprinting2.31330750
19MP0002736_abnormal_nociception_after2.18374014
20MP0003879_abnormal_hair_cell2.13871430
21MP0006276_abnormal_autonomic_nervous2.13716689
22MP0002822_catalepsy2.07744958
23MP0004885_abnormal_endolymph2.02766261
24MP0001970_abnormal_pain_threshold1.99018632
25MP0003123_paternal_imprinting1.96920646
26MP0002733_abnormal_thermal_nociception1.93311937
27MP0008877_abnormal_DNA_methylation1.92772795
28MP0001501_abnormal_sleep_pattern1.88709897
29MP0001984_abnormal_olfaction1.79564134
30MP0002067_abnormal_sensory_capabilities1.79315910
31MP0002557_abnormal_social/conspecific_i1.78045992
32MP0001440_abnormal_grooming_behavior1.69975072
33MP0003121_genomic_imprinting1.68806896
34MP0000955_abnormal_spinal_cord1.68583410
35MP0003329_amyloid_beta_deposits1.62345094
36MP0004811_abnormal_neuron_physiology1.59179424
37MP0002638_abnormal_pupillary_reflex1.56329046
38MP0002882_abnormal_neuron_morphology1.54949036
39MP0005646_abnormal_pituitary_gland1.54605570
40MP0008569_lethality_at_weaning1.52974161
41MP0004742_abnormal_vestibular_system1.49810285
42MP0002184_abnormal_innervation1.48429475
43MP0005645_abnormal_hypothalamus_physiol1.44724175
44MP0003633_abnormal_nervous_system1.38887520
45MP0005386_behavior/neurological_phenoty1.36864058
46MP0004924_abnormal_behavior1.36864058
47MP0001485_abnormal_pinna_reflex1.35868295
48MP0001188_hyperpigmentation1.34497588
49MP0005551_abnormal_eye_electrophysiolog1.32237885
50MP0002066_abnormal_motor_capabilities/c1.29825593
51MP0001905_abnormal_dopamine_level1.28638218
52MP0002909_abnormal_adrenal_gland1.26393905
53MP0009780_abnormal_chondrocyte_physiolo1.21588250
54MP0001502_abnormal_circadian_rhythm1.21359039
55MP0004133_heterotaxia1.20637003
56MP0002152_abnormal_brain_morphology1.18636957
57MP0002229_neurodegeneration1.17221408
58MP0003631_nervous_system_phenotype1.16082359
59MP0001963_abnormal_hearing_physiology1.11248478
60MP0001986_abnormal_taste_sensitivity1.09733989
61MP0003283_abnormal_digestive_organ1.09159066
62MP0004142_abnormal_muscle_tone1.05543681
63MP0002752_abnormal_somatic_nervous1.03482469
64MP0000631_abnormal_neuroendocrine_gland1.01739911
65MP0001529_abnormal_vocalization1.01502845
66MP0003690_abnormal_glial_cell1.01256167
67MP0002653_abnormal_ependyma_morphology0.96470355
68MP0006072_abnormal_retinal_apoptosis0.94449135
69MP0000026_abnormal_inner_ear0.90185939
70MP0003890_abnormal_embryonic-extraembry0.89377805
71MP0002069_abnormal_eating/drinking_beha0.84919672
72MP0003632_abnormal_nervous_system0.84512567
73MP0003861_abnormal_nervous_system0.83275955
74MP0001177_atelectasis0.82619512
75MP0000920_abnormal_myelination0.80893540
76MP0010386_abnormal_urinary_bladder0.78627551
77MP0003634_abnormal_glial_cell0.78127776
78MP0005253_abnormal_eye_physiology0.76989571
79MP0008872_abnormal_physiological_respon0.74900710
80MP0003119_abnormal_digestive_system0.72980912
81MP0005499_abnormal_olfactory_system0.71740286
82MP0005394_taste/olfaction_phenotype0.71740286
83MP0004043_abnormal_pH_regulation0.71467448
84MP0004147_increased_porphyrin_level0.69668461
85MP0004130_abnormal_muscle_cell0.67432536
86MP0004085_abnormal_heartbeat0.66758489
87MP0005195_abnormal_posterior_eye0.63106639
88MP0005535_abnormal_body_temperature0.58728238
89MP0010770_preweaning_lethality0.58252605
90MP0002082_postnatal_lethality0.58252605
91MP0003698_abnormal_male_reproductive0.57964278
92MP0003938_abnormal_ear_development0.57849999
93MP0003137_abnormal_impulse_conducting0.57638897
94MP0005410_abnormal_fertilization0.57303283
95MP0000569_abnormal_digit_pigmentation0.57006270
96MP0010769_abnormal_survival0.56851707
97MP0001299_abnormal_eye_distance/0.55148091
98MP0000604_amyloidosis0.54076453
99MP0010768_mortality/aging0.53717971
100MP0004215_abnormal_myocardial_fiber0.53649847

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.51854678
2Focal motor seizures (HP:0011153)6.09787294
3Focal seizures (HP:0007359)5.31950655
4Epileptic encephalopathy (HP:0200134)4.70292532
5Limb dystonia (HP:0002451)4.65108920
6Action tremor (HP:0002345)4.58487781
7Febrile seizures (HP:0002373)4.48432206
8Progressive cerebellar ataxia (HP:0002073)4.28636815
9Atonic seizures (HP:0010819)4.24029777
10Papilledema (HP:0001085)3.86340926
11Polyphagia (HP:0002591)3.68516342
12Generalized tonic-clonic seizures (HP:0002069)3.45444921
13Abnormal eating behavior (HP:0100738)3.37623998
14Hyperventilation (HP:0002883)3.32737771
15Dialeptic seizures (HP:0011146)3.24551006
16Ankle clonus (HP:0011448)3.23688677
17Absence seizures (HP:0002121)3.20621503
18Epileptiform EEG discharges (HP:0011182)3.17798159
19Drooling (HP:0002307)3.15591977
20Diplopia (HP:0000651)3.04377827
21Abnormality of binocular vision (HP:0011514)3.04377827
22Hemiparesis (HP:0001269)2.99705254
23Fetal akinesia sequence (HP:0001989)2.96470396
24EEG with generalized epileptiform discharges (HP:0011198)2.94965364
25Impaired vibration sensation in the lower limbs (HP:0002166)2.94249886
26Abnormality of the corticospinal tract (HP:0002492)2.92439115
27Excessive salivation (HP:0003781)2.90071074
28Hypsarrhythmia (HP:0002521)2.84815621
29Akinesia (HP:0002304)2.80279535
30Broad-based gait (HP:0002136)2.78837120
31Urinary bladder sphincter dysfunction (HP:0002839)2.67615908
32Amblyopia (HP:0000646)2.66348539
33Spastic gait (HP:0002064)2.59810002
34Agitation (HP:0000713)2.58971505
35Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.54252004
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.54252004
37Sleep apnea (HP:0010535)2.54123699
38Spastic tetraplegia (HP:0002510)2.49573670
39Urinary urgency (HP:0000012)2.48339907
40Genetic anticipation (HP:0003743)2.47087009
41Status epilepticus (HP:0002133)2.44514246
42Postural instability (HP:0002172)2.41300104
43Torticollis (HP:0000473)2.40220492
44Supranuclear gaze palsy (HP:0000605)2.32865064
45Neurofibrillary tangles (HP:0002185)2.29095153
46Intention tremor (HP:0002080)2.28323114
47Gait imbalance (HP:0002141)2.24037848
48Abnormality of the labia minora (HP:0012880)2.23200360
49Poor eye contact (HP:0000817)2.20742007
50Lissencephaly (HP:0001339)2.19604229
51Dysdiadochokinesis (HP:0002075)2.19431525
52Absent speech (HP:0001344)2.17418384
53Focal dystonia (HP:0004373)2.16857532
54Anxiety (HP:0000739)2.14887191
55Dysmetria (HP:0001310)2.13910234
56Visual hallucinations (HP:0002367)2.13795155
57Mutism (HP:0002300)2.11900598
58Gaze-evoked nystagmus (HP:0000640)2.11457370
59Morphological abnormality of the pyramidal tract (HP:0002062)2.11212486
60Hemiplegia (HP:0002301)2.11145767
61Truncal ataxia (HP:0002078)2.11096997
62Inability to walk (HP:0002540)2.08042426
63Megalencephaly (HP:0001355)2.06082340
64Poor suck (HP:0002033)2.05865414
65Impaired social interactions (HP:0000735)2.00865452
66Abnormal social behavior (HP:0012433)2.00865452
67Lower limb muscle weakness (HP:0007340)1.97322867
68Cerebral hypomyelination (HP:0006808)1.95979748
69Increased circulating renin level (HP:0000848)1.93029233
70Impaired vibratory sensation (HP:0002495)1.91750795
71Nephronophthisis (HP:0000090)1.91160135
72Depression (HP:0000716)1.86997256
73Spastic tetraparesis (HP:0001285)1.86906783
74Failure to thrive in infancy (HP:0001531)1.85930398
75Hypoplasia of the corpus callosum (HP:0002079)1.85314198
76Turricephaly (HP:0000262)1.84054655
77Optic nerve hypoplasia (HP:0000609)1.82500098
78Type II lissencephaly (HP:0007260)1.82395144
79Bradykinesia (HP:0002067)1.81195898
80Pachygyria (HP:0001302)1.78929370
81True hermaphroditism (HP:0010459)1.78738747
82Craniofacial dystonia (HP:0012179)1.78011651
83Prolonged QT interval (HP:0001657)1.77874334
84Syncope (HP:0001279)1.77504451
85Chronic hepatic failure (HP:0100626)1.76279591
86Hepatoblastoma (HP:0002884)1.74699455
87Congenital malformation of the right heart (HP:0011723)1.74269349
88Double outlet right ventricle (HP:0001719)1.74269349
89Thickened helices (HP:0000391)1.73303011
90Specific learning disability (HP:0001328)1.73002058
91Retinal dysplasia (HP:0007973)1.72025587
92Impaired smooth pursuit (HP:0007772)1.70905251
93Protruding tongue (HP:0010808)1.68519582
94Delusions (HP:0000746)1.68224270
95Cerebral inclusion bodies (HP:0100314)1.66370411
96Molar tooth sign on MRI (HP:0002419)1.66288441
97Abnormality of midbrain morphology (HP:0002418)1.66288441
98Abnormal EKG (HP:0003115)1.66155123
99Clonus (HP:0002169)1.64832350
100Intellectual disability, severe (HP:0010864)1.63814097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.94800614
2CASK4.31896342
3NTRK34.06636297
4EPHA43.80123550
5DAPK22.79672566
6PNCK2.68845860
7NTRK22.67834493
8PAK62.16447661
9UHMK12.11922700
10MAPK132.01866357
11MINK11.99497282
12MAP3K91.98113529
13SIK21.88169638
14MAP3K41.87958681
15WNK31.72585132
16PINK11.68499619
17PLK21.68265611
18PRKCG1.67270321
19TNIK1.61258127
20PHKG11.58242581
21PHKG21.58242581
22MAP2K71.52736055
23DYRK21.49165897
24CDK51.44933916
25SGK2231.43453452
26SGK4941.43453452
27FRK1.41612770
28TYRO31.37486986
29NTRK11.36396960
30CAMK1G1.30558225
31CAMKK11.29880102
32CDK191.28494146
33PRKD31.28060340
34CSNK1G21.27079507
35OXSR11.25505112
36PAK31.21675852
37CAMK11.16409405
38CAMK2B1.09136953
39SGK21.08380590
40CAMK2A1.03609735
41DYRK1A1.03271849
42FGFR21.01547231
43GRK50.94610615
44MAP2K40.94315976
45PKN10.92831979
46SGK10.90884003
47STK110.90317236
48WNK40.88963803
49EPHB20.88607064
50DYRK1B0.85873078
51PRKCH0.84943137
52LATS20.82761162
53MARK20.82711412
54CDK140.81025386
55CDK150.79666540
56DAPK10.78914041
57CSNK1G30.78538227
58PRKCZ0.77868199
59CDK180.77076230
60SGK30.75104025
61CDK11A0.73815182
62STK390.68159616
63CAMK2G0.63819496
64CSNK1G10.63257278
65CAMKK20.61865142
66CAMK2D0.61387383
67MAP3K120.58955389
68INSRR0.58034916
69PRKG10.56321696
70PRKCE0.55652749
71RPS6KA30.55278553
72CAMK1D0.55075917
73CAMK40.54900955
74ARAF0.54874636
75MAPK120.51480942
76CSNK1A1L0.47478013
77BCR0.46981509
78CSNK1E0.46939988
79PRKACA0.46729091
80TIE10.46616056
81MAPK150.46395830
82MAP4K20.46036039
83ADRBK20.45169351
84CDK30.44121074
85BRAF0.42974022
86WNK10.42710895
87MAPK100.41262143
88ALK0.40862707
89PRKAA10.39452747
90PRKCA0.38848262
91CSNK1D0.37277328
92STK380.36360648
93CSNK1A10.34502429
94ROCK20.34389661
95NEK60.34330640
96MAPKAPK50.33861442
97ROCK10.32972489
98BMPR1B0.32904678
99PRKCB0.32442337
100GSK3B0.30910268

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.41766420
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09458692
3GABAergic synapse_Homo sapiens_hsa047272.78232347
4Circadian entrainment_Homo sapiens_hsa047132.74608510
5Morphine addiction_Homo sapiens_hsa050322.72275957
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71272872
7Insulin secretion_Homo sapiens_hsa049112.65885570
8Amphetamine addiction_Homo sapiens_hsa050312.65034737
9Glutamatergic synapse_Homo sapiens_hsa047242.64162320
10Dopaminergic synapse_Homo sapiens_hsa047282.42319709
11Cocaine addiction_Homo sapiens_hsa050302.32358602
12Long-term potentiation_Homo sapiens_hsa047202.17340381
13Cholinergic synapse_Homo sapiens_hsa047251.86056558
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79102187
15Gastric acid secretion_Homo sapiens_hsa049711.75062847
16Taste transduction_Homo sapiens_hsa047421.67229094
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64913328
18Salivary secretion_Homo sapiens_hsa049701.64124849
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63816065
20Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58097838
21Cardiac muscle contraction_Homo sapiens_hsa042601.53479378
22Serotonergic synapse_Homo sapiens_hsa047261.49293572
23Long-term depression_Homo sapiens_hsa047301.48235318
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46310424
25Renin secretion_Homo sapiens_hsa049241.45816003
26Oxytocin signaling pathway_Homo sapiens_hsa049211.42071878
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39202905
28cAMP signaling pathway_Homo sapiens_hsa040241.37662445
29Phototransduction_Homo sapiens_hsa047441.36857382
30Calcium signaling pathway_Homo sapiens_hsa040201.32263765
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32102223
32Olfactory transduction_Homo sapiens_hsa047401.27701675
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24720150
34Axon guidance_Homo sapiens_hsa043601.21430055
35Collecting duct acid secretion_Homo sapiens_hsa049661.17543319
36Dorso-ventral axis formation_Homo sapiens_hsa043201.16078923
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12431621
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.12103821
39Gap junction_Homo sapiens_hsa045401.11768442
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04317999
41Estrogen signaling pathway_Homo sapiens_hsa049151.02610576
42Butanoate metabolism_Homo sapiens_hsa006501.02463781
43Type II diabetes mellitus_Homo sapiens_hsa049300.97797850
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97757927
45Pancreatic secretion_Homo sapiens_hsa049720.97216337
46Melanogenesis_Homo sapiens_hsa049160.91717772
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89153353
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88325548
49GnRH signaling pathway_Homo sapiens_hsa049120.87442741
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86477907
51Bile secretion_Homo sapiens_hsa049760.82426992
52Thyroid hormone synthesis_Homo sapiens_hsa049180.80652708
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.74361112
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71274981
55Oocyte meiosis_Homo sapiens_hsa041140.69501174
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69071886
57Alzheimers disease_Homo sapiens_hsa050100.68300027
58Ras signaling pathway_Homo sapiens_hsa040140.65037184
59Vibrio cholerae infection_Homo sapiens_hsa051100.65009565
60Vitamin B6 metabolism_Homo sapiens_hsa007500.64360411
61Oxidative phosphorylation_Homo sapiens_hsa001900.62685584
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62208360
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60513436
64Glioma_Homo sapiens_hsa052140.59547610
65ErbB signaling pathway_Homo sapiens_hsa040120.59232933
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.57423289
67Alcoholism_Homo sapiens_hsa050340.55684614
68MAPK signaling pathway_Homo sapiens_hsa040100.55668134
69Rap1 signaling pathway_Homo sapiens_hsa040150.55421777
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55109023
71Ether lipid metabolism_Homo sapiens_hsa005650.54737726
72Parkinsons disease_Homo sapiens_hsa050120.53538332
73Inositol phosphate metabolism_Homo sapiens_hsa005620.53232611
74* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51601612
75Dilated cardiomyopathy_Homo sapiens_hsa054140.49949702
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.45419770
77Glucagon signaling pathway_Homo sapiens_hsa049220.45168665
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44391327
79Tight junction_Homo sapiens_hsa045300.43497609
80Ovarian steroidogenesis_Homo sapiens_hsa049130.43392799
81Fatty acid biosynthesis_Homo sapiens_hsa000610.42591731
82Mineral absorption_Homo sapiens_hsa049780.40812486
83Nitrogen metabolism_Homo sapiens_hsa009100.39711501
84Wnt signaling pathway_Homo sapiens_hsa043100.39153272
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38995239
86Hippo signaling pathway_Homo sapiens_hsa043900.38212341
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38183113
88Linoleic acid metabolism_Homo sapiens_hsa005910.38100867
89Regulation of autophagy_Homo sapiens_hsa041400.37566896
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.36039999
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35352278
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33697236
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.33022241
94Tryptophan metabolism_Homo sapiens_hsa003800.32825918
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.32618005
96Hedgehog signaling pathway_Homo sapiens_hsa043400.31467644
97Arginine and proline metabolism_Homo sapiens_hsa003300.30504826
98Protein digestion and absorption_Homo sapiens_hsa049740.29708615
99Huntingtons disease_Homo sapiens_hsa050160.29457805
100Glycerolipid metabolism_Homo sapiens_hsa005610.29411225

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