GALNT14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.94330192
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.94330192
3microtubule nucleation (GO:0007020)6.78562344
4folic acid-containing compound biosynthetic process (GO:0009396)6.60760483
5homocysteine metabolic process (GO:0050667)6.53622408
6purine nucleotide salvage (GO:0032261)6.41747501
7cysteine metabolic process (GO:0006534)6.28979616
8sulfur amino acid catabolic process (GO:0000098)6.17199582
9aminoglycoside antibiotic metabolic process (GO:0030647)5.61399021
10regulation of plasminogen activation (GO:0010755)5.45477311
11desmosome organization (GO:0002934)5.38893241
12protein-cofactor linkage (GO:0018065)5.19381438
13detection of calcium ion (GO:0005513)4.92090977
14pteridine-containing compound biosynthetic process (GO:0042559)4.83698043
15cochlea development (GO:0090102)4.57963549
16IMP biosynthetic process (GO:0006188)4.56740063
17sensory perception of smell (GO:0007608)4.50033442
18white fat cell differentiation (GO:0050872)4.48322898
19regulation of short-term neuronal synaptic plasticity (GO:0048172)4.38706587
20L-serine metabolic process (GO:0006563)4.35754558
21regulation of synaptic vesicle exocytosis (GO:2000300)4.35400312
22synaptic vesicle exocytosis (GO:0016079)4.29953930
23adenosine metabolic process (GO:0046085)4.23291830
24glycoside metabolic process (GO:0016137)4.18294267
25serine family amino acid biosynthetic process (GO:0009070)4.16687589
26inner ear receptor cell development (GO:0060119)4.16600536
27alternative mRNA splicing, via spliceosome (GO:0000380)4.11664445
28sulfur amino acid biosynthetic process (GO:0000097)4.09130402
29neuron cell-cell adhesion (GO:0007158)4.08893673
30galactose catabolic process (GO:0019388)4.07632796
31nucleotide salvage (GO:0043173)3.98876129
32mitochondrial RNA metabolic process (GO:0000959)3.97002841
33neuronal action potential propagation (GO:0019227)3.93626826
34protein localization to cilium (GO:0061512)3.90947060
35polyketide metabolic process (GO:0030638)3.88444268
36doxorubicin metabolic process (GO:0044598)3.88444268
37daunorubicin metabolic process (GO:0044597)3.88444268
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87161738
39histone H4-K12 acetylation (GO:0043983)3.86792450
40synaptic vesicle docking involved in exocytosis (GO:0016081)3.82822631
41negative regulation of keratinocyte proliferation (GO:0010839)3.80895628
42growth hormone secretion (GO:0030252)3.73774849
43female mating behavior (GO:0060180)3.72946704
44regulation of synaptic vesicle transport (GO:1902803)3.72646282
45glutamate secretion (GO:0014047)3.67000661
46IMP metabolic process (GO:0046040)3.64824502
47phosphate ion transport (GO:0006817)3.64564300
48tRNA modification (GO:0006400)3.61724985
49polyamine metabolic process (GO:0006595)3.58747945
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.54632708
51organic cation transport (GO:0015695)3.53915358
52vocalization behavior (GO:0071625)3.52482786
53galactose metabolic process (GO:0006012)3.52168427
54sensory perception of chemical stimulus (GO:0007606)3.49067478
55synaptic vesicle maturation (GO:0016188)3.43577909
56positive regulation of amino acid transport (GO:0051957)3.40238028
57protein-chromophore linkage (GO:0018298)3.40214868
58epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.39798358
59urate metabolic process (GO:0046415)3.38876428
60phosphatidylglycerol biosynthetic process (GO:0006655)3.36594878
61adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.36157220
62regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.35426265
63COPII vesicle coating (GO:0048208)3.35206445
64phosphorelay signal transduction system (GO:0000160)3.34499617
65regulation of female receptivity (GO:0045924)3.29689034
66transferrin transport (GO:0033572)3.29462903
67NADH dehydrogenase complex assembly (GO:0010257)3.29398248
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29398248
69mitochondrial respiratory chain complex I assembly (GO:0032981)3.29398248
70energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28851430
71ATP hydrolysis coupled proton transport (GO:0015991)3.28851430
72negative regulation of DNA biosynthetic process (GO:2000279)3.28199860
73regulation of vitamin D biosynthetic process (GO:0060556)3.25854511
74neurotransmitter secretion (GO:0007269)3.25180552
75neuronal action potential (GO:0019228)3.24259949
76energy homeostasis (GO:0097009)3.21498253
77regulation of gonadotropin secretion (GO:0032276)3.21022329
78locomotory exploration behavior (GO:0035641)3.18485485
79folic acid-containing compound metabolic process (GO:0006760)3.18352903
80polyamine biosynthetic process (GO:0006596)3.17902860
81rRNA methylation (GO:0031167)3.15931173
82guanosine-containing compound biosynthetic process (GO:1901070)3.15024977
83GMP metabolic process (GO:0046037)3.14718744
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14492769
85regulation of glutamate receptor signaling pathway (GO:1900449)3.11335433
86trivalent inorganic cation transport (GO:0072512)3.10909334
87ferric iron transport (GO:0015682)3.10909334
88presynaptic membrane assembly (GO:0097105)3.10554195
89membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10475061
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08781622
91rRNA modification (GO:0000154)3.07973816
92protein localization to synapse (GO:0035418)3.06733065
93tetrahydrofolate metabolic process (GO:0046653)3.05847787
94proline transport (GO:0015824)3.02525139
95pyrimidine nucleobase catabolic process (GO:0006208)3.02178292
96calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01992709
97cellular response to glucagon stimulus (GO:0071377)3.01477296
98primary amino compound metabolic process (GO:1901160)3.01007455
99negative regulation of dendrite morphogenesis (GO:0050774)3.00885058
100preassembly of GPI anchor in ER membrane (GO:0016254)3.00450946
101purine-containing compound salvage (GO:0043101)3.00022286
102negative regulation of catecholamine secretion (GO:0033604)2.99279939
103tRNA processing (GO:0008033)2.98133305
104cartilage morphogenesis (GO:0060536)2.96075082
105acrosome assembly (GO:0001675)2.95892990
106striatum development (GO:0021756)2.92992965
107membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.92960305
1084-hydroxyproline metabolic process (GO:0019471)2.92754208
109activation of protein kinase A activity (GO:0034199)2.92241625
110insulin secretion (GO:0030073)2.92104309
111nucleoside transmembrane transport (GO:1901642)2.90342775
112L-methionine salvage (GO:0071267)2.89681333
113L-methionine biosynthetic process (GO:0071265)2.89681333
114amino acid salvage (GO:0043102)2.89681333
115neuron recognition (GO:0008038)2.88665193
116peptidyl-proline hydroxylation (GO:0019511)2.88416410
117postsynaptic membrane organization (GO:0001941)2.87317305
118positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.87032097
119negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85986288
120neurofilament cytoskeleton organization (GO:0060052)2.85149968
121protein maturation by protein folding (GO:0022417)2.82749306
122positive regulation of membrane potential (GO:0045838)2.82625405
123sulfur amino acid metabolic process (GO:0000096)2.82603305
124potassium ion transmembrane transport (GO:0071805)2.81871097
125cellular potassium ion transport (GO:0071804)2.81871097
126intraciliary transport (GO:0042073)2.81314182
127neuron-neuron synaptic transmission (GO:0007270)2.80492016
128behavioral fear response (GO:0001662)2.79492514
129behavioral defense response (GO:0002209)2.79492514
130negative regulation of Notch signaling pathway (GO:0045746)2.79090778
131presynaptic membrane organization (GO:0097090)2.79049545
132membrane depolarization during action potential (GO:0086010)2.78795369
133regulation of penile erection (GO:0060405)2.78635110
134regulation of neuronal synaptic plasticity (GO:0048168)2.78284826
135regulation of neurotransmitter secretion (GO:0046928)2.77952060
136C-terminal protein lipidation (GO:0006501)2.77914104
137glycosphingolipid biosynthetic process (GO:0006688)2.77230903
138neurotransmitter transport (GO:0006836)2.76750364
139calcium ion-dependent exocytosis (GO:0017156)2.75771033
140ER overload response (GO:0006983)2.75351729
141Golgi transport vesicle coating (GO:0048200)2.74280625
142COPI coating of Golgi vesicle (GO:0048205)2.74280625
143pteridine-containing compound metabolic process (GO:0042558)2.73625737
144substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73557597
145substrate-independent telencephalic tangential migration (GO:0021826)2.73557597
146folic acid metabolic process (GO:0046655)2.72539853
147long-term synaptic potentiation (GO:0060291)2.70709063
148exploration behavior (GO:0035640)2.70409326
149innervation (GO:0060384)2.70374372
150gamma-aminobutyric acid transport (GO:0015812)2.70186052
151cerebellar Purkinje cell differentiation (GO:0021702)2.70118687
152behavioral response to cocaine (GO:0048148)2.70054366
153synapse assembly (GO:0007416)2.68268263
154artery smooth muscle contraction (GO:0014824)2.67987397
155neurotransmitter-gated ion channel clustering (GO:0072578)2.67869331
156multicellular organismal reproductive behavior (GO:0033057)2.67803454
157alpha-amino acid biosynthetic process (GO:1901607)2.67695772
158peptide hormone processing (GO:0016486)2.67514641
159synaptic transmission, glutamatergic (GO:0035249)2.66934560
160melanosome transport (GO:0032402)2.66709214
161protein insertion into membrane (GO:0051205)2.66429253
162negative regulation of Ras GTPase activity (GO:0034261)2.66270369
163startle response (GO:0001964)2.66099581
164negative regulation of norepinephrine secretion (GO:0010700)2.65507994
165synaptic vesicle endocytosis (GO:0048488)2.65449087
166positive regulation of exocytosis (GO:0045921)2.65146282
167multi-organism reproductive behavior (GO:0044705)2.64867073
168regulation of vesicle fusion (GO:0031338)2.64642225
169urinary tract smooth muscle contraction (GO:0014848)2.64272763
170mating behavior (GO:0007617)2.63455926
171potassium ion transport (GO:0006813)2.61412767
172establishment of melanosome localization (GO:0032401)2.60821832
173regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60707403
174drug transport (GO:0015893)2.60661758
175drug transmembrane transport (GO:0006855)2.59919994
176ribosome biogenesis (GO:0042254)2.59740900
177pigment granule transport (GO:0051904)2.59031674
178negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.58890011
179membrane repolarization during action potential (GO:0086011)2.58881251
180protein complex biogenesis (GO:0070271)2.58776879
181negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58713869
182nucleobase catabolic process (GO:0046113)2.58464022
183positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.56697842
184negative regulation of cation channel activity (GO:2001258)2.56648563
185axonal fasciculation (GO:0007413)2.56033035
186lactate metabolic process (GO:0006089)2.55906626
187establishment of pigment granule localization (GO:0051905)2.53760879
188negative regulation of amine transport (GO:0051953)2.53161425
189cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.52981515
190regulation of neurotransmitter transport (GO:0051588)2.52747569
191succinate metabolic process (GO:0006105)2.51704122
192regulation of insulin secretion (GO:0050796)2.50603279
193regulation of long-term neuronal synaptic plasticity (GO:0048169)2.49300727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.72487015
2EZH2_22144423_ChIP-Seq_EOC_Human6.53783546
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.50590755
4E2F7_22180533_ChIP-Seq_HELA_Human4.82264259
5GBX2_23144817_ChIP-Seq_PC3_Human4.02266008
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.38989064
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.02483366
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95069427
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71975934
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68712495
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.61938862
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60033891
13* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.57386688
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52379450
15TAF15_26573619_Chip-Seq_HEK293_Human2.51315570
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49521984
17* REST_21632747_ChIP-Seq_MESCs_Mouse2.44410311
18GABP_19822575_ChIP-Seq_HepG2_Human2.38148322
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37369288
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35564323
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33670682
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.28545362
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25007630
24* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23290091
25* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23290091
26BMI1_23680149_ChIP-Seq_NPCS_Mouse2.22827586
27* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16605244
28ZNF263_19887448_ChIP-Seq_K562_Human2.15252840
29* EZH2_27304074_Chip-Seq_ESCs_Mouse2.13041655
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.11543670
31* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09710661
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05900696
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03586802
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03001117
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02700852
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.02181660
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.98498671
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95810505
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.94731372
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93263584
41KDM5A_27292631_Chip-Seq_BREAST_Human1.92476947
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91017947
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90671521
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89569070
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.86079828
46DROSHA_22980978_ChIP-Seq_HELA_Human1.84622590
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82563765
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81529953
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.80543198
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.76226774
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75712036
52* RNF2_27304074_Chip-Seq_ESCs_Mouse1.75507258
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.72436721
54P300_19829295_ChIP-Seq_ESCs_Human1.72410006
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65812324
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57641759
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57291312
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55967212
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.55235891
60XRN2_22483619_ChIP-Seq_HELA_Human1.53830313
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51585877
62IGF1R_20145208_ChIP-Seq_DFB_Human1.47951551
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47408126
64EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46410781
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45908397
66VDR_23849224_ChIP-Seq_CD4+_Human1.45315791
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45118371
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44895274
69RNF2_27304074_Chip-Seq_NSC_Mouse1.44050646
70ELK1_19687146_ChIP-ChIP_HELA_Human1.43185733
71FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43155465
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42341215
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.42069164
74FOXP3_21729870_ChIP-Seq_TREG_Human1.39613602
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.38032399
76* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37934417
77AHR_22903824_ChIP-Seq_MCF-7_Human1.35636835
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35307766
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.33854426
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32839404
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32586185
82VDR_22108803_ChIP-Seq_LS180_Human1.32497995
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.31911047
84TP53_22573176_ChIP-Seq_HFKS_Human1.31087128
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30271502
86* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29369603
87STAT3_23295773_ChIP-Seq_U87_Human1.27519641
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27023323
89* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26407374
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26344903
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.23739562
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23291699
93MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21990604
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20476676
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20205715
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19648248
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19619324
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19383603
99ZNF274_21170338_ChIP-Seq_K562_Hela1.19251240
100THAP11_20581084_ChIP-Seq_MESCs_Mouse1.19201866
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19020530
102DCP1A_22483619_ChIP-Seq_HELA_Human1.18333058
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.18109194
104HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17692884
105* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17652629
106AR_25329375_ChIP-Seq_VCAP_Human1.16885805
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16721929
108TP63_19390658_ChIP-ChIP_HaCaT_Human1.16369694
109* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.13608702
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12944542
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12668811
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12106735
113TCF4_23295773_ChIP-Seq_U87_Human1.11714891
114ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11687379
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11148147
116HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10552482
117* RUNX2_22187159_ChIP-Seq_PCA_Human1.09685306
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08902188
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08135898
120NCOR_22424771_ChIP-Seq_293T_Human1.08010714
121MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07387353
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06139425
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.05931376
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.04522939
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02278072
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01179477
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.00955752
128RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00860254
129PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.00781287
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00467329
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00137331
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00133032
133SMAD3_21741376_ChIP-Seq_ESCs_Human1.00075755
134* AR_19668381_ChIP-Seq_PC3_Human0.99216715
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98990540
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97723150
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97711410
138CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97066516
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96452333
140NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96352958
141BCAT_22108803_ChIP-Seq_LS180_Human0.96101319
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95822912
143LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94661998
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94607969
145* JUN_21703547_ChIP-Seq_K562_Human0.94285033
146FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94252048
147FOXA1_25329375_ChIP-Seq_VCAP_Human0.94252048
148* SOX2_20726797_ChIP-Seq_SW620_Human0.94186462
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.93944230
150POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93894309
151TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93894309
152SRF_21415370_ChIP-Seq_HL-1_Mouse0.93640005
153* KDM2B_26808549_Chip-Seq_REH_Human0.93555248
154ER_23166858_ChIP-Seq_MCF-7_Human0.93261128
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93145976
156YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92898867
157P53_22387025_ChIP-Seq_ESCs_Mouse0.92719321
158MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92716128
159DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92415022
160FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92355217
161* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92082793
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91573536
163ERG_21242973_ChIP-ChIP_JURKAT_Human0.91316864
164PRDM14_20953172_ChIP-Seq_ESCs_Human0.90754940
165ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89718347
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89273768
167FLI1_21867929_ChIP-Seq_TH2_Mouse0.89127609
168FUS_26573619_Chip-Seq_HEK293_Human0.88785610
169IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88248645
170CBP_20019798_ChIP-Seq_JUKART_Human0.88248645
171AR_21572438_ChIP-Seq_LNCaP_Human0.87684980
172RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87643005
173ETS1_21867929_ChIP-Seq_TH2_Mouse0.87280455
174MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86531468
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86468634
176NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86223800
177TP53_22127205_ChIP-Seq_IMR90_Human0.83183874
178SMAD_19615063_ChIP-ChIP_OVARY_Human0.80820833
179KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80762852
180RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80753168
181CREB1_15753290_ChIP-ChIP_HEK293T_Human0.80580925
182* CDX2_22108803_ChIP-Seq_LS180_Human0.79347284
183SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79159164
184SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79159164
185CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79087795
186ESR1_21235772_ChIP-Seq_MCF-7_Human0.78311221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction4.44066396
2MP0005360_urolithiasis4.43983800
3MP0008995_early_reproductive_senescence3.64436871
4MP0005670_abnormal_white_adipose3.18563261
5MP0004270_analgesia3.16478899
6MP0004859_abnormal_synaptic_plasticity3.14890808
7MP0005645_abnormal_hypothalamus_physiol2.97866768
8MP0009780_abnormal_chondrocyte_physiolo2.88045429
9MP0004043_abnormal_pH_regulation2.85666282
10MP0003635_abnormal_synaptic_transmissio2.75364044
11MP0010386_abnormal_urinary_bladder2.71564170
12MP0002735_abnormal_chemical_nociception2.68398344
13MP0002734_abnormal_mechanical_nocicepti2.54559826
14MP0003880_abnormal_central_pattern2.46057032
15MP0002138_abnormal_hepatobiliary_system2.41321930
16MP0006276_abnormal_autonomic_nervous2.37370179
17MP0002837_dystrophic_cardiac_calcinosis2.32622337
18MP0005394_taste/olfaction_phenotype2.32416572
19MP0005499_abnormal_olfactory_system2.32416572
20MP0008789_abnormal_olfactory_epithelium2.26403674
21MP0002063_abnormal_learning/memory/cond2.26292179
22MP0009745_abnormal_behavioral_response2.22006341
23MP0002822_catalepsy2.21672083
24MP0001968_abnormal_touch/_nociception2.20009652
25MP0002064_seizures2.16840230
26MP0005367_renal/urinary_system_phenotyp2.14737837
27MP0000516_abnormal_urinary_system2.14737837
28MP0002272_abnormal_nervous_system2.12340207
29MP0002877_abnormal_melanocyte_morpholog2.12101018
30MP0002909_abnormal_adrenal_gland2.08242206
31MP0002572_abnormal_emotion/affect_behav2.07739581
32MP0002184_abnormal_innervation2.06535696
33MP0002876_abnormal_thyroid_physiology2.04262452
34MP0005646_abnormal_pituitary_gland2.03226116
35MP0009046_muscle_twitch2.01684773
36MP0003705_abnormal_hypodermis_morpholog1.97763464
37MP0000013_abnormal_adipose_tissue1.86795343
38MP0002736_abnormal_nociception_after1.86565962
39MP0002733_abnormal_thermal_nociception1.84905557
40MP0003183_abnormal_peptide_metabolism1.84301762
41MP0001764_abnormal_homeostasis1.79323678
42MP0004858_abnormal_nervous_system1.79315859
43MP0001970_abnormal_pain_threshold1.78893382
44MP0002132_abnormal_respiratory_system1.78417390
45MP0002557_abnormal_social/conspecific_i1.74801858
46MP0003786_premature_aging1.72495614
47MP0001486_abnormal_startle_reflex1.71621055
48MP0002067_abnormal_sensory_capabilities1.67857564
49MP0003283_abnormal_digestive_organ1.61924400
50MP0005084_abnormal_gallbladder_morpholo1.59786944
51MP0002234_abnormal_pharynx_morphology1.59184685
52MP0005332_abnormal_amino_acid1.58609272
53MP0003879_abnormal_hair_cell1.56688722
54MP0001501_abnormal_sleep_pattern1.56635730
55MP0001986_abnormal_taste_sensitivity1.55642648
56MP0003787_abnormal_imprinting1.53875897
57MP0001502_abnormal_circadian_rhythm1.49157317
58MP0002396_abnormal_hematopoietic_system1.48814807
59MP0000678_abnormal_parathyroid_gland1.46527312
60MP0003122_maternal_imprinting1.43789383
61MP0001485_abnormal_pinna_reflex1.41883430
62MP0002693_abnormal_pancreas_physiology1.41823884
63MP0002095_abnormal_skin_pigmentation1.38521716
64MP0001188_hyperpigmentation1.33331085
65MP0000778_abnormal_nervous_system1.31797920
66MP0001944_abnormal_pancreas_morphology1.30151497
67MP0003195_calcinosis1.29971216
68MP0004811_abnormal_neuron_physiology1.28763573
69MP0000467_abnormal_esophagus_morphology1.27968137
70MP0000762_abnormal_tongue_morphology1.27805661
71MP0008058_abnormal_DNA_repair1.24949810
72MP0005423_abnormal_somatic_nervous1.23933645
73MP0001661_extended_life_span1.23686978
74MP0005379_endocrine/exocrine_gland_phen1.23319513
75MP0001440_abnormal_grooming_behavior1.22339652
76MP0000647_abnormal_sebaceous_gland1.21322006
77MP0002882_abnormal_neuron_morphology1.20161172
78MP0000372_irregular_coat_pigmentation1.16780949
79MP0002638_abnormal_pupillary_reflex1.15179059
80MP0004885_abnormal_endolymph1.13563364
81MP0008872_abnormal_physiological_respon1.12436245
82MP0004134_abnormal_chest_morphology1.11189220
83MP0004924_abnormal_behavior1.10778229
84MP0005386_behavior/neurological_phenoty1.10778229
85MP0001765_abnormal_ion_homeostasis1.10632490
86MP0000955_abnormal_spinal_cord1.09943658
87MP0001270_distended_abdomen1.09528888
88MP0004742_abnormal_vestibular_system1.09401969
89MP0001963_abnormal_hearing_physiology1.08299864
90MP0002098_abnormal_vibrissa_morphology1.06901762
91MP0000538_abnormal_urinary_bladder1.06722045
92MP0003806_abnormal_nucleotide_metabolis1.06399567
93MP0005451_abnormal_body_composition1.05898771
94MP0002066_abnormal_motor_capabilities/c1.05376149
95MP0001756_abnormal_urination1.04995715
96MP0001216_abnormal_epidermal_layer1.03700334
97MP0002751_abnormal_autonomic_nervous1.02415482
98MP0002160_abnormal_reproductive_system1.02372188
99MP0000631_abnormal_neuroendocrine_gland1.02186342
100MP0010678_abnormal_skin_adnexa1.02031522
101MP0005535_abnormal_body_temperature1.00085889
102MP0001529_abnormal_vocalization0.99611896
103MP0006072_abnormal_retinal_apoptosis0.99500458
104MP0000049_abnormal_middle_ear0.98960510
105MP0002938_white_spotting0.97164913
106MP0003252_abnormal_bile_duct0.95458035
107MP0002078_abnormal_glucose_homeostasis0.94941587
108MP0002229_neurodegeneration0.94940037
109MP0008569_lethality_at_weaning0.94791060
110MP0002069_abnormal_eating/drinking_beha0.94738529
111MP0003315_abnormal_perineum_morphology0.94214041
112MP0003724_increased_susceptibility_to0.92871156
113MP0000003_abnormal_adipose_tissue0.90763075
114MP0004133_heterotaxia0.89600955
115MP0002752_abnormal_somatic_nervous0.89209198
116MP0000579_abnormal_nail_morphology0.89140961
117MP0002928_abnormal_bile_duct0.83989526
118MP0001905_abnormal_dopamine_level0.83742388
119MP0003755_abnormal_palate_morphology0.81940182
120MP0002332_abnormal_exercise_endurance0.81682610
121MP0000026_abnormal_inner_ear0.80896476
122MP0005375_adipose_tissue_phenotype0.79128613
123MP0010094_abnormal_chromosome_stability0.78720845
124MP0003633_abnormal_nervous_system0.77348573
125MP0003953_abnormal_hormone_level0.76095882
126MP0003186_abnormal_redox_activity0.75703448
127MP0002152_abnormal_brain_morphology0.74906295
128MP0005501_abnormal_skin_physiology0.74292191
129MP0005551_abnormal_eye_electrophysiolog0.73515995
130MP0001664_abnormal_digestion0.72199971
131MP0010771_integument_phenotype0.71900813
132MP0009643_abnormal_urine_homeostasis0.70901190
133MP0005253_abnormal_eye_physiology0.70639984
134MP0002896_abnormal_bone_mineralization0.69937828
135MP0002177_abnormal_outer_ear0.69694794
136MP0004142_abnormal_muscle_tone0.69562827
137MP0003172_abnormal_lysosome_physiology0.69044842
138MP0000750_abnormal_muscle_regeneration0.69016216
139MP0004185_abnormal_adipocyte_glucose0.68912475
140MP0004085_abnormal_heartbeat0.67746941
141MP0000383_abnormal_hair_follicle0.67610767
142MP0000681_abnormal_thyroid_gland0.67373663
143MP0005310_abnormal_salivary_gland0.65814970
144MP0003329_amyloid_beta_deposits0.65417647
145MP0001340_abnormal_eyelid_morphology0.65409803
146MP0004147_increased_porphyrin_level0.64683475
147MP0002653_abnormal_ependyma_morphology0.62724169
148MP0005636_abnormal_mineral_homeostasis0.62655552
149MP0008961_abnormal_basal_metabolism0.62639530
150MP0001177_atelectasis0.60377547
151MP0003935_abnormal_craniofacial_develop0.60290446
152MP0002139_abnormal_hepatobiliary_system0.60095622
153MP0005376_homeostasis/metabolism_phenot0.59381334
154MP0003221_abnormal_cardiomyocyte_apopto0.58964266
155MP0000534_abnormal_ureter_morphology0.57945621
156MP0002697_abnormal_eye_size0.57722362

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)7.16161130
2Abnormality of alanine metabolism (HP:0010916)7.16161130
3Hyperalaninemia (HP:0003348)7.16161130
4Constricted visual fields (HP:0001133)5.66567144
5Focal motor seizures (HP:0011153)4.93763101
6Atonic seizures (HP:0010819)4.39411217
7Febrile seizures (HP:0002373)4.38964961
8Visual hallucinations (HP:0002367)4.22551618
9Esophageal varix (HP:0002040)4.21227988
10Congenital sensorineural hearing impairment (HP:0008527)4.18223164
11Hypothermia (HP:0002045)4.06333261
12Myokymia (HP:0002411)3.73271661
13Focal seizures (HP:0007359)3.61101870
14Hyperactive renin-angiotensin system (HP:0000841)3.60924733
15Pendular nystagmus (HP:0012043)3.57892575
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.53889886
17Chorioretinal atrophy (HP:0000533)3.49459670
18Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.48485042
19Ankle clonus (HP:0011448)3.47324977
20Thyroid-stimulating hormone excess (HP:0002925)3.45241072
21Absence seizures (HP:0002121)3.40224526
22Decreased circulating renin level (HP:0003351)3.38037251
23Heterochromia iridis (HP:0001100)3.33497999
24White forelock (HP:0002211)3.22567020
25Increased circulating renin level (HP:0000848)3.15845623
26Hyperventilation (HP:0002883)3.13820412
27Generalized tonic-clonic seizures (HP:0002069)3.05618229
28Gait imbalance (HP:0002141)3.00207677
29Dialeptic seizures (HP:0011146)3.00147224
30Medial flaring of the eyebrow (HP:0010747)3.00088933
31Pheochromocytoma (HP:0002666)2.99284656
32Epileptic encephalopathy (HP:0200134)2.98966595
33Retinal dysplasia (HP:0007973)2.98954068
34Patchy hypopigmentation of hair (HP:0011365)2.97866811
35Abnormality of renin-angiotensin system (HP:0000847)2.95149208
36Abnormal umbilical cord blood vessels (HP:0011403)2.94892119
37Single umbilical artery (HP:0001195)2.94892119
38Abnormality of the fetal cardiovascular system (HP:0010948)2.94892119
39Hypokalemic alkalosis (HP:0001949)2.92416617
40Abnormality of calcium-phosphate metabolism (HP:0100530)2.89404727
41Nephrogenic diabetes insipidus (HP:0009806)2.84121186
42Congenital primary aphakia (HP:0007707)2.81520981
43Focal segmental glomerulosclerosis (HP:0000097)2.81040705
44Hypomagnesemia (HP:0002917)2.77052054
45Spontaneous hematomas (HP:0007420)2.75792821
46Birth length less than 3rd percentile (HP:0003561)2.74796590
47Neuroendocrine neoplasm (HP:0100634)2.74465303
48Clonus (HP:0002169)2.73658353
49Metabolic alkalosis (HP:0200114)2.71426725
50Poor speech (HP:0002465)2.71149971
51Hypokalemia (HP:0002900)2.69764272
52Abnormal hair whorl (HP:0010721)2.66011299
53Conjugated hyperbilirubinemia (HP:0002908)2.63112217
54Epileptiform EEG discharges (HP:0011182)2.62830313
55Hypoglycemic seizures (HP:0002173)2.62445109
56EEG with generalized epileptiform discharges (HP:0011198)2.62410232
57Acute necrotizing encephalopathy (HP:0006965)2.60431743
58Generalized aminoaciduria (HP:0002909)2.60422919
59Hyperinsulinemic hypoglycemia (HP:0000825)2.57715775
60Agitation (HP:0000713)2.56341701
61Abnormality of magnesium homeostasis (HP:0004921)2.55467595
62Conjunctival telangiectasia (HP:0000524)2.54538620
63Cortical visual impairment (HP:0100704)2.52243375
64B lymphocytopenia (HP:0010976)2.51946187
65Hyperaldosteronism (HP:0000859)2.50447329
66Intention tremor (HP:0002080)2.49407092
67Abnormal mitochondria in muscle tissue (HP:0008316)2.49161399
68Symptomatic seizures (HP:0011145)2.49055332
69Gout (HP:0001997)2.47690964
70Limb dystonia (HP:0002451)2.46249724
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.46196906
72Hypsarrhythmia (HP:0002521)2.45474353
73Polyuria (HP:0000103)2.43689291
74Progressive macrocephaly (HP:0004481)2.42801291
75Aplasia/hypoplasia of the uterus (HP:0008684)2.40159021
76Abnormality of serum amino acid levels (HP:0003112)2.38394242
77Stenosis of the external auditory canal (HP:0000402)2.37192657
78Glomerulosclerosis (HP:0000096)2.34043960
79Vaginal atresia (HP:0000148)2.31373750
80Polydipsia (HP:0001959)2.31235718
81Abnormal drinking behavior (HP:0030082)2.31235718
82Ketoacidosis (HP:0001993)2.29927669
83Attenuation of retinal blood vessels (HP:0007843)2.29409539
84Genital tract atresia (HP:0001827)2.28775143
85Amblyopia (HP:0000646)2.28545910
86Anosmia (HP:0000458)2.28321306
87Myocardial infarction (HP:0001658)2.27995575
88Insulin-resistant diabetes mellitus (HP:0000831)2.26601133
89Hypoplasia of the thymus (HP:0000778)2.25423471
90Fatigue (HP:0012378)2.23953911
91Anxiety (HP:0000739)2.23499272
92Acute encephalopathy (HP:0006846)2.22908709
93Abnormality of the lower motor neuron (HP:0002366)2.21515983
94Abnormality of homocysteine metabolism (HP:0010919)2.20854158
95Homocystinuria (HP:0002156)2.20854158
96Dyskinesia (HP:0100660)2.20261726
97Abnormality of chloride homeostasis (HP:0011422)2.17747699
98Bifid tongue (HP:0010297)2.17481819
99Unilateral renal agenesis (HP:0000122)2.16996864
100Abnormal urine output (HP:0012590)2.15339626
101Abnormal ciliary motility (HP:0012262)2.15064858
102Anorexia (HP:0002039)2.14537935
103Failure to thrive in infancy (HP:0001531)2.13972088
104Abnormality of potassium homeostasis (HP:0011042)2.13549923
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.13490849
106Lissencephaly (HP:0001339)2.13459066
107Progressive cerebellar ataxia (HP:0002073)2.11800944
108Truncal ataxia (HP:0002078)2.11609040
109Abnormality of the vasculature of the conjunctiva (HP:0008054)2.10837151
110Rhinitis (HP:0012384)2.09478191
111Hyperuricemia (HP:0002149)2.08549880
112Increased purine levels (HP:0004368)2.08549880
113Abnormality of renal excretion (HP:0011036)2.08049555
114Abnormal respiratory motile cilium physiology (HP:0012261)2.06807180
115Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05242627
116Chronic bronchitis (HP:0004469)2.05166082
117Hypoplasia of the uterus (HP:0000013)2.01897601
118Molar tooth sign on MRI (HP:0002419)2.01112243
119Abnormality of midbrain morphology (HP:0002418)2.01112243
120Muscular hypotonia of the trunk (HP:0008936)2.00982948
121Spastic gait (HP:0002064)2.00486541
122Abnormality of the umbilical cord (HP:0010881)1.98932093
123Osteomalacia (HP:0002749)1.97934449
124Type II lissencephaly (HP:0007260)1.97694049
125Tubulointerstitial nephritis (HP:0001970)1.97162669
126Abnormality of B cell number (HP:0010975)1.95531248
127Poor coordination (HP:0002370)1.94483739
128Abnormal respiratory motile cilium morphology (HP:0005938)1.94143051
129Abnormal respiratory epithelium morphology (HP:0012253)1.94143051
130Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.93698800
131Abnormal eating behavior (HP:0100738)1.93005714
132Granulocytopenia (HP:0001913)1.92816246
133Abnormal pancreas size (HP:0012094)1.92496757
134Epidermoid cyst (HP:0200040)1.92435236
135Abnormality of macular pigmentation (HP:0008002)1.92141513
136Tetany (HP:0001281)1.91039850
137Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90616588
138Alkalosis (HP:0001948)1.90353482
139Abnormality of the labia minora (HP:0012880)1.89654215
140Dysautonomia (HP:0002459)1.88737513
141Spastic diplegia (HP:0001264)1.87817446
142Arteriovenous malformation (HP:0100026)1.87565164
143Onycholysis (HP:0001806)1.85515546
144Adrenal overactivity (HP:0002717)1.85345689
145Abnormality of glycolysis (HP:0004366)1.84798736
146Absent eyebrow (HP:0002223)1.81760064
147Mitochondrial inheritance (HP:0001427)1.81088564
148Depression (HP:0000716)1.81059487
149Cortical dysplasia (HP:0002539)1.80534733
150Action tremor (HP:0002345)1.80296882
151Increased serum pyruvate (HP:0003542)1.79723409
152Plantar hyperkeratosis (HP:0007556)1.78510830
153Hypokinesia (HP:0002375)1.77742351
154Oligomenorrhea (HP:0000876)1.77474350
155Visceral angiomatosis (HP:0100761)1.77385183
156Bradycardia (HP:0001662)1.76714682
157Poor suck (HP:0002033)1.76631561
158Late onset (HP:0003584)1.76504340
159Progressive inability to walk (HP:0002505)1.76286524
160Brittle hair (HP:0002299)1.75905728
161Excessive salivation (HP:0003781)1.75425424
162Drooling (HP:0002307)1.75425424
163Polyphagia (HP:0002591)1.74765805
164Inability to walk (HP:0002540)1.74297429
165Carpal bone hypoplasia (HP:0001498)1.74217764
166Erythroderma (HP:0001019)1.74088788
167Short tibia (HP:0005736)1.73590129
168Disproportionate short-trunk short stature (HP:0003521)1.73500042
169Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73027434
170Abnormal protein N-linked glycosylation (HP:0012347)1.73027434
171Abnormal protein glycosylation (HP:0012346)1.73027434
172Abnormal glycosylation (HP:0012345)1.73027434
173Fragile nails (HP:0001808)1.72307035
174Proximal tubulopathy (HP:0000114)1.72167042
175Reduced subcutaneous adipose tissue (HP:0003758)1.71559526
176Spastic tetraplegia (HP:0002510)1.71183747
177Pancreatic fibrosis (HP:0100732)1.71129434
178Type II diabetes mellitus (HP:0005978)1.70890210
179Aplasia/Hypoplasia of the lens (HP:0008063)1.70814677
180Torticollis (HP:0000473)1.69865383
181Menstrual irregularities (HP:0000858)1.69642510
182Increased serum lactate (HP:0002151)1.69528216
183Absent speech (HP:0001344)1.69140206
184Abnormality of purine metabolism (HP:0004352)1.68604309
185Bone marrow hypocellularity (HP:0005528)1.66725127
186Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63606922
187Hypopigmentation of the fundus (HP:0007894)1.62503858
188Abnormality of the renal collecting system (HP:0004742)1.60799269
189Abnormality of nucleobase metabolism (HP:0010932)1.60426578
190Maternal diabetes (HP:0009800)1.59854790
191Abolished electroretinogram (ERG) (HP:0000550)1.59728005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.15011503
2NTRK34.13021687
3INSRR3.48947281
4MAP2K73.31657075
5MAP3K33.17424658
6CASK3.13980040
7MAP2K32.99574518
8MAP3K42.89244732
9CDK92.37753544
10LMTK22.37666538
11MST1R2.35688311
12WNK42.24148119
13MAP3K122.22196217
14MINK12.19310866
15EPHA22.09561773
16WNK32.07195840
17MAP3K21.93962605
18EPHA41.91584858
19PHKG21.86114206
20PHKG11.86114206
21MARK11.85071651
22ARAF1.83522060
23GRK51.78054821
24RPS6KA41.75893840
25NTRK11.74216742
26MAP2K41.69266288
27SRPK11.68624163
28MAPK131.68232135
29DAPK21.65539732
30TESK11.62886648
31AKT31.62274614
32EPHB21.62264787
33EIF2AK31.61277109
34CAMKK21.61265612
35PRKD31.56792793
36SIK31.56740005
37SGK2231.56332936
38SGK4941.56332936
39PIM21.56160407
40RPS6KB21.56112979
41MAPK151.55951955
42ERBB31.53791183
43NEK11.52328658
44PRPF4B1.51978118
45BMPR21.51270610
46PKN21.51011058
47BRD41.49297317
48SGK21.48873052
49MET1.47806221
50TAOK11.45809585
51MAP4K21.43478543
52OXSR11.42957334
53BCKDK1.42458793
54BRAF1.40930875
55DYRK21.40869662
56PLK21.36208235
57FGR1.35407256
58HIPK21.33558641
59JAK31.31524564
60PASK1.30333116
61STK38L1.25586742
62CCNB11.24903160
63NTRK21.23725102
64CSNK1G11.19343503
65PRKCG1.19250085
66FLT31.18717093
67DAPK11.12557199
68CDK51.09717743
69RIPK41.09716375
70PRKCE1.06259885
71MAP3K91.03128289
72CAMKK10.97381455
73ZAK0.97285068
74CAMK2B0.96144146
75FRK0.95521704
76IRAK30.93574391
77PNCK0.93192010
78MUSK0.92671570
79PAK30.92544717
80TNIK0.92345362
81UHMK10.92064022
82AURKA0.91419136
83MAP3K50.91289801
84DYRK1A0.91059528
85BMPR1B0.86785722
86BCR0.85465692
87RPS6KA20.84739185
88CAMK2A0.80261297
89CSNK1G20.80027768
90CAMK2D0.79119582
91PAK60.77645541
92WNK10.77487149
93SGK30.77238159
94CDK70.76853221
95FER0.73181687
96STK380.72110834
97PRKCH0.69095201
98NEK60.69002794
99SIK20.68919048
100ADRBK20.67937370
101ACVR1B0.67616368
102TIE10.67040426
103MAP2K60.66710720
104CDC42BPA0.66570370
105IRAK40.62455067
106CAMK2G0.62266378
107SCYL20.62000671
108MAP3K10.61984532
109NME10.61958206
110KSR10.59494315
111PAK40.59307612
112CDK80.58944959
113DAPK30.57725556
114STK390.57142582
115KSR20.56656695
116ADRBK10.52354943
117PRKACA0.52339226
118MAP3K60.51478878
119CSNK1A1L0.51153877
120MAP2K10.50747647
121STK240.50661477
122PRKCZ0.49065133
123RET0.47323456
124TAOK30.46721603
125STK160.44762044
126TAF10.44755661
127SGK10.44334070
128CAMK10.42711631
129CSNK1G30.42604200
130CSNK1A10.41622833
131CAMK1G0.41257739
132ATR0.40640489
133RPS6KA10.39102263
134PINK10.38185222
135MAP3K110.37925370
136RPS6KB10.37790727
137EGFR0.37526069
138LIMK10.36601065
139IRAK10.36320137
140CAMK40.34923881
141PRKACG0.34429705
142CDK140.34272386
143MARK20.33667953
144ERBB40.33471728
145AKT20.33130879
146IRAK20.32844956
147SIK10.31572358
148PRKCI0.30923098
149EIF2AK10.27556496
150CHEK20.26682817
151VRK10.26538507
152PRKCD0.26199501
153DYRK30.25821348

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.99839295
2Synaptic vesicle cycle_Homo sapiens_hsa047213.43107710
3Collecting duct acid secretion_Homo sapiens_hsa049663.33884542
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.01285050
5One carbon pool by folate_Homo sapiens_hsa006702.87695924
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79706544
7Selenocompound metabolism_Homo sapiens_hsa004502.68765238
8Insulin secretion_Homo sapiens_hsa049112.68348326
9Galactose metabolism_Homo sapiens_hsa000522.45711640
10Vibrio cholerae infection_Homo sapiens_hsa051102.45009822
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.36674338
12Taste transduction_Homo sapiens_hsa047422.34459686
13GABAergic synapse_Homo sapiens_hsa047272.21301870
14Nicotine addiction_Homo sapiens_hsa050332.20204291
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.19991529
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.13916923
17Arginine biosynthesis_Homo sapiens_hsa002202.09164959
18Morphine addiction_Homo sapiens_hsa050322.07852544
19Circadian entrainment_Homo sapiens_hsa047132.07808425
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.06146722
21Sulfur relay system_Homo sapiens_hsa041222.01915778
22Oxidative phosphorylation_Homo sapiens_hsa001901.95254383
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91530594
24Amphetamine addiction_Homo sapiens_hsa050311.90442169
25Base excision repair_Homo sapiens_hsa034101.87530261
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87459684
27Dopaminergic synapse_Homo sapiens_hsa047281.86745853
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.84356551
29Long-term potentiation_Homo sapiens_hsa047201.70591064
30Glutamatergic synapse_Homo sapiens_hsa047241.69921832
31Serotonergic synapse_Homo sapiens_hsa047261.68866775
32Cholinergic synapse_Homo sapiens_hsa047251.65356532
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.53068656
34Sulfur metabolism_Homo sapiens_hsa009201.49470865
35Biosynthesis of amino acids_Homo sapiens_hsa012301.45291162
36Protein export_Homo sapiens_hsa030601.44413123
37Cocaine addiction_Homo sapiens_hsa050301.42665569
38Butanoate metabolism_Homo sapiens_hsa006501.40444061
39Type I diabetes mellitus_Homo sapiens_hsa049401.36452015
40Parkinsons disease_Homo sapiens_hsa050121.36132726
41Non-homologous end-joining_Homo sapiens_hsa034501.34053454
42Type II diabetes mellitus_Homo sapiens_hsa049301.32859867
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30071535
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29975652
45Alzheimers disease_Homo sapiens_hsa050101.28850658
46Salivary secretion_Homo sapiens_hsa049701.28373492
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28233868
48Gastric acid secretion_Homo sapiens_hsa049711.25441474
49Phototransduction_Homo sapiens_hsa047441.21823188
50Proteasome_Homo sapiens_hsa030501.19118381
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13882862
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10039976
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09522006
54Renin secretion_Homo sapiens_hsa049241.09226067
55Fanconi anemia pathway_Homo sapiens_hsa034601.08300543
56SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07668572
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.06792310
58Calcium signaling pathway_Homo sapiens_hsa040201.06736179
59mRNA surveillance pathway_Homo sapiens_hsa030151.05288889
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03758632
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03319969
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00214624
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99425980
64Basal transcription factors_Homo sapiens_hsa030220.98373947
65Cardiac muscle contraction_Homo sapiens_hsa042600.96598608
66Long-term depression_Homo sapiens_hsa047300.95856039
67Folate biosynthesis_Homo sapiens_hsa007900.95119692
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95010079
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94653477
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93215147
71Fructose and mannose metabolism_Homo sapiens_hsa000510.93088118
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91194324
73Pyrimidine metabolism_Homo sapiens_hsa002400.90612321
74DNA replication_Homo sapiens_hsa030300.88651079
75Huntingtons disease_Homo sapiens_hsa050160.87502737
76Ether lipid metabolism_Homo sapiens_hsa005650.86718452
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86127881
78Glucagon signaling pathway_Homo sapiens_hsa049220.85563971
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85334756
80Thyroid hormone synthesis_Homo sapiens_hsa049180.85023638
81Regulation of autophagy_Homo sapiens_hsa041400.83832702
82cAMP signaling pathway_Homo sapiens_hsa040240.83718874
83Spliceosome_Homo sapiens_hsa030400.82045878
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80138880
85beta-Alanine metabolism_Homo sapiens_hsa004100.79201373
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78630793
87Rheumatoid arthritis_Homo sapiens_hsa053230.78277881
88Oxytocin signaling pathway_Homo sapiens_hsa049210.77318916
89GnRH signaling pathway_Homo sapiens_hsa049120.74492114
90* Metabolic pathways_Homo sapiens_hsa011000.73505481
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72574683
92Pancreatic secretion_Homo sapiens_hsa049720.72262084
93Gap junction_Homo sapiens_hsa045400.71954003
94RNA transport_Homo sapiens_hsa030130.71935399
95Purine metabolism_Homo sapiens_hsa002300.71746771
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70955154
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70855107
98Estrogen signaling pathway_Homo sapiens_hsa049150.68992942
99Glioma_Homo sapiens_hsa052140.64689069
100Pyruvate metabolism_Homo sapiens_hsa006200.63848869
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.63210096
102Phagosome_Homo sapiens_hsa041450.62643788
103Alcoholism_Homo sapiens_hsa050340.62588192
104Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62541990
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61863478
106RNA degradation_Homo sapiens_hsa030180.61014251
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60068595
108Peroxisome_Homo sapiens_hsa041460.59417626
109Pentose phosphate pathway_Homo sapiens_hsa000300.59248199
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.59154226
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54144229
112Melanogenesis_Homo sapiens_hsa049160.53821265
113Sphingolipid metabolism_Homo sapiens_hsa006000.50353632
114Insulin signaling pathway_Homo sapiens_hsa049100.50301700
115ErbB signaling pathway_Homo sapiens_hsa040120.49669963
116Arginine and proline metabolism_Homo sapiens_hsa003300.49511344
117Fatty acid elongation_Homo sapiens_hsa000620.49031896
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47277138
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45486726
120N-Glycan biosynthesis_Homo sapiens_hsa005100.44502497
121Carbon metabolism_Homo sapiens_hsa012000.44125096
122Lysosome_Homo sapiens_hsa041420.43473831
123Retinol metabolism_Homo sapiens_hsa008300.42431966
124Circadian rhythm_Homo sapiens_hsa047100.41627098
125* Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41388400
126RNA polymerase_Homo sapiens_hsa030200.40952811
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40770313
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39519933
129Starch and sucrose metabolism_Homo sapiens_hsa005000.39475786
130Ras signaling pathway_Homo sapiens_hsa040140.39073973
131Homologous recombination_Homo sapiens_hsa034400.37492735
132Shigellosis_Homo sapiens_hsa051310.37075553
133Other glycan degradation_Homo sapiens_hsa005110.36892692
134Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35738913
135Axon guidance_Homo sapiens_hsa043600.34152649
136Melanoma_Homo sapiens_hsa052180.33438067
137Vitamin digestion and absorption_Homo sapiens_hsa049770.33253686
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32838119
139Ovarian steroidogenesis_Homo sapiens_hsa049130.32405101
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31335735
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.30785854
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.30686137
143Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30581674
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30036307
145Prolactin signaling pathway_Homo sapiens_hsa049170.29788389
146Endometrial cancer_Homo sapiens_hsa052130.29729102
147Glutathione metabolism_Homo sapiens_hsa004800.29213478
148Neurotrophin signaling pathway_Homo sapiens_hsa047220.28481506
149Fatty acid biosynthesis_Homo sapiens_hsa000610.28330546
150Nitrogen metabolism_Homo sapiens_hsa009100.28265619
151Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28184213
152Mineral absorption_Homo sapiens_hsa049780.27865756
153Bile secretion_Homo sapiens_hsa049760.27074967
154Mismatch repair_Homo sapiens_hsa034300.26663899
155Choline metabolism in cancer_Homo sapiens_hsa052310.25860264
156MAPK signaling pathway_Homo sapiens_hsa040100.25328965
157Glycosaminoglycan degradation_Homo sapiens_hsa005310.24638236
158Prion diseases_Homo sapiens_hsa050200.24433316
159Nucleotide excision repair_Homo sapiens_hsa034200.23541383
160Inositol phosphate metabolism_Homo sapiens_hsa005620.20627674

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