GALM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucuronate metabolic process (GO:0019585)6.65643582
2uronic acid metabolic process (GO:0006063)6.65643582
3cellular glucuronidation (GO:0052695)6.51239781
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.49970825
5L-phenylalanine catabolic process (GO:0006559)6.49970825
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.27450580
7L-phenylalanine metabolic process (GO:0006558)6.27450580
8aromatic amino acid family catabolic process (GO:0009074)5.93963610
9response to nitrosative stress (GO:0051409)5.90858521
10sulfur amino acid catabolic process (GO:0000098)5.77152255
11xenobiotic catabolic process (GO:0042178)5.72868394
12glyoxylate metabolic process (GO:0046487)5.53010022
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.51981643
14indole-containing compound catabolic process (GO:0042436)5.50944821
15indolalkylamine catabolic process (GO:0046218)5.50944821
16tryptophan catabolic process (GO:0006569)5.50944821
17bile acid biosynthetic process (GO:0006699)5.33158734
18kynurenine metabolic process (GO:0070189)5.33056674
19cysteine metabolic process (GO:0006534)5.19835872
20tryptophan metabolic process (GO:0006568)5.18313927
21high-density lipoprotein particle remodeling (GO:0034375)5.09965125
22urea metabolic process (GO:0019627)4.96218947
23urea cycle (GO:0000050)4.96218947
24alpha-linolenic acid metabolic process (GO:0036109)4.89251667
25benzene-containing compound metabolic process (GO:0042537)4.86937364
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85898959
27regulation of cholesterol esterification (GO:0010872)4.76390665
28aldehyde catabolic process (GO:0046185)4.64497063
29regulation of fibrinolysis (GO:0051917)4.61208367
30amino-acid betaine metabolic process (GO:0006577)4.58671989
31nitrogen cycle metabolic process (GO:0071941)4.58512446
32bile acid metabolic process (GO:0008206)4.57929532
33serine family amino acid catabolic process (GO:0009071)4.54078841
34negative regulation of fibrinolysis (GO:0051918)4.50793810
35lysine catabolic process (GO:0006554)4.49784004
36lysine metabolic process (GO:0006553)4.49784004
37peptidyl-glutamic acid carboxylation (GO:0017187)4.49669576
38protein carboxylation (GO:0018214)4.49669576
39reverse cholesterol transport (GO:0043691)4.47046542
40complement activation, alternative pathway (GO:0006957)4.44063448
41ethanol oxidation (GO:0006069)4.43722947
42regulation of protein activation cascade (GO:2000257)4.42957681
43cytidine deamination (GO:0009972)4.42580118
44cytidine metabolic process (GO:0046087)4.42580118
45cytidine catabolic process (GO:0006216)4.42580118
46homocysteine metabolic process (GO:0050667)4.39379861
47regulation of triglyceride catabolic process (GO:0010896)4.37216432
48phospholipid efflux (GO:0033700)4.33618543
49aromatic amino acid family metabolic process (GO:0009072)4.31715356
50flavonoid metabolic process (GO:0009812)4.28185756
51protein-lipid complex remodeling (GO:0034368)4.27797413
52macromolecular complex remodeling (GO:0034367)4.27797413
53plasma lipoprotein particle remodeling (GO:0034369)4.27797413
54regulation of cholesterol biosynthetic process (GO:0045540)4.15581570
55regulation of complement activation (GO:0030449)4.14591621
56drug catabolic process (GO:0042737)4.08564588
57tyrosine metabolic process (GO:0006570)4.07773474
58alpha-amino acid catabolic process (GO:1901606)4.05618474
59acylglycerol homeostasis (GO:0055090)4.01267149
60triglyceride homeostasis (GO:0070328)4.01267149
61bile acid and bile salt transport (GO:0015721)3.99058011
62negative regulation of cholesterol transport (GO:0032375)3.98978298
63negative regulation of sterol transport (GO:0032372)3.98978298
64L-ascorbic acid metabolic process (GO:0019852)3.89588686
65cellular biogenic amine catabolic process (GO:0042402)3.89331317
66amine catabolic process (GO:0009310)3.89331317
67cellular amino acid catabolic process (GO:0009063)3.88889339
68cholesterol efflux (GO:0033344)3.87017455
69cellular ketone body metabolic process (GO:0046950)3.86737971
70indolalkylamine metabolic process (GO:0006586)3.84740567
71protein-lipid complex assembly (GO:0065005)3.84418493
72serine family amino acid metabolic process (GO:0009069)3.83278712
73pyrimidine ribonucleoside catabolic process (GO:0046133)3.80859881
74regulation of bile acid biosynthetic process (GO:0070857)3.80602454
75phospholipid homeostasis (GO:0055091)3.80263879
76regulation of cholesterol metabolic process (GO:0090181)3.78694362
77imidazole-containing compound metabolic process (GO:0052803)3.76335115
78cellular modified amino acid catabolic process (GO:0042219)3.74308303
79negative regulation of lipase activity (GO:0060192)3.74276988
80plasma lipoprotein particle clearance (GO:0034381)3.72749841
81glycine metabolic process (GO:0006544)3.72233773
82eosinophil chemotaxis (GO:0048245)3.70994897
83low-density lipoprotein particle remodeling (GO:0034374)3.69943413
84carnitine metabolic process (GO:0009437)3.68159086
85DNA deamination (GO:0045006)3.67950651
86carboxylic acid catabolic process (GO:0046395)3.63031869
87organic acid catabolic process (GO:0016054)3.63031869
88plasma lipoprotein particle assembly (GO:0034377)3.62608291
89glutamate metabolic process (GO:0006536)3.60495078
90glutathione derivative metabolic process (GO:1901685)3.59991322
91glutathione derivative biosynthetic process (GO:1901687)3.59991322
92very-low-density lipoprotein particle assembly (GO:0034379)3.58438996
93fatty acid oxidation (GO:0019395)3.58367780
94regulation of cholesterol homeostasis (GO:2000188)3.58311589
95coenzyme catabolic process (GO:0009109)3.57716800
96drug transmembrane transport (GO:0006855)3.57631465
97monocarboxylic acid catabolic process (GO:0072329)3.57573932
98fatty acid beta-oxidation (GO:0006635)3.52490084
99serine family amino acid biosynthetic process (GO:0009070)3.52182989
100lipid oxidation (GO:0034440)3.51482963
101short-chain fatty acid metabolic process (GO:0046459)3.51328964
102plasma lipoprotein particle organization (GO:0071827)3.50291963
103drug metabolic process (GO:0017144)3.46801422
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.45853223
105arginine metabolic process (GO:0006525)3.45465658
106cholesterol homeostasis (GO:0042632)3.44822569
107intestinal cholesterol absorption (GO:0030299)3.44549606
108phenylpropanoid metabolic process (GO:0009698)3.43879048
109positive regulation of lipoprotein lipase activity (GO:0051006)3.43181681
110glycosphingolipid catabolic process (GO:0046479)3.42978301
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.37000554
112protein-lipid complex subunit organization (GO:0071825)3.29779440
113eosinophil migration (GO:0072677)3.27089907
114regulation of cholesterol storage (GO:0010885)3.21942723
115glycolipid catabolic process (GO:0019377)3.12307499
116response to interferon-beta (GO:0035456)3.04231154
117oligosaccharide catabolic process (GO:0009313)3.00152936
118positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.96877790
119lipoprotein metabolic process (GO:0042157)2.96700929
120fat-soluble vitamin biosynthetic process (GO:0042362)2.96085023
121regulation of cytokine secretion involved in immune response (GO:0002739)2.93058954
122regulation of mononuclear cell migration (GO:0071675)2.92438368
123ceramide catabolic process (GO:0046514)2.92182999
124neutrophil activation involved in immune response (GO:0002283)2.90287497
125positive regulation of triglyceride lipase activity (GO:0061365)2.88933587
126positive regulation of gamma-delta T cell activation (GO:0046645)2.87809237
127regulation of T cell tolerance induction (GO:0002664)2.86453768
128positive regulation of defense response to virus by host (GO:0002230)2.85843431
129cellular response to interleukin-15 (GO:0071350)2.85633622
130pyrimidine nucleoside catabolic process (GO:0046135)2.81373931
131positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.81168872
132response to interleukin-15 (GO:0070672)2.81030877
133immunoglobulin mediated immune response (GO:0016064)2.80824026
134positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.80743674
135cellular response to interferon-beta (GO:0035458)2.79898506
136lipoprotein transport (GO:0042953)2.79440344
137sterol transport (GO:0015918)2.76450294
138cholesterol transport (GO:0030301)2.76450294
139antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72508450
140regulation of interleukin-2 biosynthetic process (GO:0045076)2.69398413
141negative regulation of interleukin-1 beta production (GO:0032691)2.67121176
142antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.66217459
143intestinal absorption (GO:0050892)2.62629898
144negative regulation of interleukin-12 production (GO:0032695)2.61332667
145angiotensin maturation (GO:0002003)2.58887178
146regulation of macrophage chemotaxis (GO:0010758)2.57763877
147regulation of superoxide anion generation (GO:0032928)2.54219859
148antigen processing and presentation of endogenous antigen (GO:0019883)2.53391105
149regulation of macrophage derived foam cell differentiation (GO:0010743)2.52078598
150response to thyroid hormone (GO:0097066)2.50770512
151positive regulation of monocyte chemotaxis (GO:0090026)2.50760514
152regulation of regulatory T cell differentiation (GO:0045589)2.49512376
153regulation of natural killer cell mediated immunity (GO:0002715)2.49164941
154regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.49164941
155regulation of activation of Janus kinase activity (GO:0010533)2.49112622
156heme transport (GO:0015886)2.48222897
157regulation of vitamin metabolic process (GO:0030656)2.47190593
158epoxygenase P450 pathway (GO:0019373)2.45694652
159antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.43393276
160regulation of leukocyte mediated cytotoxicity (GO:0001910)2.42247488
161N-acetylneuraminate metabolic process (GO:0006054)2.42112740
162positive regulation of calcium-mediated signaling (GO:0050850)2.41862803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.67781022
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.69551742
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.44749144
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.04969001
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01627011
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.74995588
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.55184946
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.10671789
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74426771
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.72417113
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.64035956
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.10031775
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.97475990
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.87100160
15* IRF8_27001747_Chip-Seq_BMDM_Mouse2.46465067
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.42510433
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.35853981
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12287022
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.11614102
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03027203
21CLOCK_20551151_ChIP-Seq_293T_Human2.01552447
22* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8062531
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95819146
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.94756743
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.93261550
26LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.92150673
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90901353
28VDR_22108803_ChIP-Seq_LS180_Human1.90166069
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88497371
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.86026381
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84501584
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77893565
33SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76232752
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70130412
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69232290
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66385579
37SPI1_23547873_ChIP-Seq_NB4_Human1.64213930
38* MYB_26560356_Chip-Seq_TH2_Human1.63495341
39GATA3_26560356_Chip-Seq_TH2_Human1.59692665
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55775877
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.47572460
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.44735582
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43628455
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.42421482
45RUNX_20019798_ChIP-Seq_JUKART_Human1.42188863
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41990612
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41886425
48LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41309058
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.39447865
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.38064917
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.37118747
52GATA3_27048872_Chip-Seq_THYMUS_Human1.36273336
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35502090
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33824170
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.33566621
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.32253273
57* HNF4A_19822575_ChIP-Seq_HepG2_Human1.31833889
58GATA4_25053715_ChIP-Seq_YYC3_Human1.30513608
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29142004
60CDX2_20551321_ChIP-Seq_CACO-2_Human1.24668948
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24086251
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23817666
63SPI1_23127762_ChIP-Seq_K562_Human1.22237972
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19320067
65CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18931133
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18542590
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18379391
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18115432
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17339844
70* MYB_26560356_Chip-Seq_TH1_Human1.17199376
71STAT1_20625510_ChIP-Seq_HELA_Human1.16680180
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15572509
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15231624
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14854311
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13571313
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10031057
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09768013
78FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08601917
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06134668
80* VDR_24787735_ChIP-Seq_THP-1_Human1.03659025
81RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02753181
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.01575290
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01563478
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00414301
85HTT_18923047_ChIP-ChIP_STHdh_Human0.98911563
86EST1_17652178_ChIP-ChIP_JURKAT_Human0.97895745
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97237573
88ZNF263_19887448_ChIP-Seq_K562_Human0.95236635
89NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92795235
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91695610
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91555624
92NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91555624
93* FOXP3_21729870_ChIP-Seq_TREG_Human0.91147123
94BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91101207
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.90173892
96SOX2_20726797_ChIP-Seq_SW620_Human0.89094521
97VDR_23849224_ChIP-Seq_CD4+_Human0.88670495
98RUNX1_22412390_ChIP-Seq_EML_Mouse0.88530061
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87647824
100NANOG_20526341_ChIP-Seq_ESCs_Human0.87524528
101SCL_19346495_ChIP-Seq_HPC-7_Human0.86777521
102GATA6_25053715_ChIP-Seq_YYC3_Human0.85862997
103STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85735228
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84752283
105KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84632378
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.84354770
107GATA1_22025678_ChIP-Seq_K562_Human0.83637192
108PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82740960
109POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.82195471
110FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82170995
111FOXA1_25329375_ChIP-Seq_VCAP_Human0.82170995
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81921800
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81906725
114BP1_19119308_ChIP-ChIP_Hs578T_Human0.81473535
115FOXH1_21741376_ChIP-Seq_ESCs_Human0.81461501
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.80929449
117TP63_17297297_ChIP-ChIP_HaCaT_Human0.80808281
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80207807
119SOX2_19829295_ChIP-Seq_ESCs_Human0.78806330
120NANOG_19829295_ChIP-Seq_ESCs_Human0.78806330
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78564108
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.78465990
123PCGF2_27294783_Chip-Seq_NPCs_Mouse0.77566513
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77199580
125GATA3_26560356_Chip-Seq_TH1_Human0.76463717
126GATA3_21878914_ChIP-Seq_MCF-7_Human0.76154142
127FOXO3_23340844_ChIP-Seq_DLD1_Human0.76115892
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75743046
129TAF2_19829295_ChIP-Seq_ESCs_Human0.75534197
130ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75511938
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.75144246
132FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75119249
133BCOR_27268052_Chip-Seq_Bcells_Human0.75096443
134BCL6_27268052_Chip-Seq_Bcells_Human0.74831970
135GATA3_24758297_ChIP-Seq_MCF-7_Human0.74481911
136CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.74478157
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.71861442
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71667134
139ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63666463
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63378585
141BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63227452
142NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.61808264
143CEBPB_22108803_ChIP-Seq_LS180_Human0.61076506
144TCF3_18692474_ChIP-Seq_MEFs_Mouse0.60260125
145PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.59334775
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.59037054
147PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.57769372
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.57626381
149PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.56777392
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56610949
151AR_21909140_ChIP-Seq_LNCAP_Human0.56105396
152SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.54665709
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.52869134
154ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.52496005
155STAT1_17558387_ChIP-Seq_HELA_Human0.52111012
156RACK7_27058665_Chip-Seq_MCF-7_Human0.51362400
157AR_20517297_ChIP-Seq_VCAP_Human0.50357316
158ERG_20517297_ChIP-Seq_VCAP_Human0.49862266
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.49583260
160TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.49552648
161RARB_24833708_ChIP-Seq_LIVER_Mouse0.48954507
162ESET_19884257_ChIP-Seq_ESCs_Mouse0.47766282
163CDX2_22108803_ChIP-Seq_LS180_Human0.47383607
164SOX2_18692474_ChIP-Seq_MEFs_Mouse0.46841828
165* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.45601451
166GATA2_21666600_ChIP-Seq_HMVEC_Human0.45337495
167P63_26484246_Chip-Seq_KERATINOCYTES_Human0.44218495
168* GATA2_19941826_ChIP-Seq_K562_Human0.43631338
169TP63_23658742_ChIP-Seq_EP156T_Human0.43134517
170BCAT_22108803_ChIP-Seq_LS180_Human0.41716213
171PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.41395735
172SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.41044057
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.40481958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.26972296
2MP0005360_urolithiasis7.00302266
3MP0005085_abnormal_gallbladder_physiolo5.92568185
4MP0008875_abnormal_xenobiotic_pharmacok5.81808971
5MP0005365_abnormal_bile_salt5.75439340
6MP0003806_abnormal_nucleotide_metabolis4.09055707
7MP0005671_abnormal_response_to3.69633739
8MP0003252_abnormal_bile_duct3.51086136
9MP0010329_abnormal_lipoprotein_level3.40482811
10MP0009840_abnormal_foam_cell3.20051372
11MP0001835_abnormal_antigen_presentation2.68361191
12MP0005332_abnormal_amino_acid2.67089732
13MP0005083_abnormal_biliary_tract2.62071202
14MP0009785_altered_susceptibility_to2.60310414
15MP0001666_abnormal_nutrient_absorption2.51412861
16MP0004019_abnormal_vitamin_homeostasis2.46196412
17MP0003195_calcinosis2.45743955
18MP0005058_abnormal_lysosome_morphology2.41887450
19MP0002148_abnormal_hypersensitivity_rea2.38113779
20MP0003186_abnormal_redox_activity2.32635713
21MP0003191_abnormal_cellular_cholesterol2.20555709
22MP0009333_abnormal_splenocyte_physiolog2.16017554
23MP0005025_abnormal_response_to2.10398925
24MP0001790_abnormal_immune_system2.09424493
25MP0005387_immune_system_phenotype2.09424493
26MP0005000_abnormal_immune_tolerance1.97109682
27MP0001800_abnormal_humoral_immune1.90539618
28MP0000609_abnormal_liver_physiology1.89014344
29MP0002118_abnormal_lipid_homeostasis1.86093940
30MP0002419_abnormal_innate_immunity1.81155306
31MP0002723_abnormal_immune_serum1.79489471
32MP0005319_abnormal_enzyme/_coenzyme1.76680902
33MP0002452_abnormal_antigen_presenting1.67599051
34MP0010155_abnormal_intestine_physiology1.66747576
35MP0002138_abnormal_hepatobiliary_system1.65310740
36MP0001845_abnormal_inflammatory_respons1.64194343
37MP0000685_abnormal_immune_system1.61335710
38MP0001764_abnormal_homeostasis1.56064052
39MP0003183_abnormal_peptide_metabolism1.53931033
40MP0001853_heart_inflammation1.53069039
41MP0003866_abnormal_defecation1.51138355
42MP0002420_abnormal_adaptive_immunity1.51043342
43MP0001819_abnormal_immune_cell1.50317052
44MP0009643_abnormal_urine_homeostasis1.45176560
45MP0003172_abnormal_lysosome_physiology1.42909235
46MP0009697_abnormal_copulation1.41707099
47MP0005584_abnormal_enzyme/coenzyme_acti1.41502337
48MP0008789_abnormal_olfactory_epithelium1.39871515
49MP0000343_altered_response_to1.36995986
50MP0005499_abnormal_olfactory_system1.34647913
51MP0005394_taste/olfaction_phenotype1.34647913
52MP0005451_abnormal_body_composition1.34451557
53MP0008004_abnormal_stomach_pH1.32827342
54MP0004147_increased_porphyrin_level1.32327045
55MP0002405_respiratory_system_inflammati1.31144284
56MP0002254_reproductive_system_inflammat1.29417208
57MP0003763_abnormal_thymus_physiology1.27624901
58MP0001533_abnormal_skeleton_physiology1.26087692
59MP0000372_irregular_coat_pigmentation1.25536501
60MP0005408_hypopigmentation1.23303670
61MP0003868_abnormal_feces_composition1.22595079
62MP0010368_abnormal_lymphatic_system1.21445250
63MP0002837_dystrophic_cardiac_calcinosis1.20277621
64MP0001873_stomach_inflammation1.19748357
65MP0002277_abnormal_respiratory_mucosa1.19418393
66MP0005647_abnormal_sex_gland1.17860998
67MP0000716_abnormal_immune_system1.15426685
68MP0003705_abnormal_hypodermis_morpholog1.14903362
69MP0008995_early_reproductive_senescence1.11049876
70MP0005310_abnormal_salivary_gland1.10664395
71MP0000689_abnormal_spleen_morphology1.06778202
72MP0000598_abnormal_liver_morphology1.04347981
73MP0001984_abnormal_olfaction1.03920999
74MP0004043_abnormal_pH_regulation1.02831360
75MP0003656_abnormal_erythrocyte_physiolo1.01233039
76MP0002998_abnormal_bone_remodeling0.99785902
77MP0003011_delayed_dark_adaptation0.98965047
78MP0000371_diluted_coat_color0.98716359
79MP0009764_decreased_sensitivity_to0.98198423
80MP0005636_abnormal_mineral_homeostasis0.97519770
81MP0002398_abnormal_bone_marrow0.97022032
82MP0009763_increased_sensitivity_to0.95877873
83MP0002429_abnormal_blood_cell0.94951466
84MP0003303_peritoneal_inflammation0.93379057
85MP0005670_abnormal_white_adipose0.91014691
86MP0009053_abnormal_anal_canal0.90871030
87MP0005084_abnormal_gallbladder_morpholo0.89976325
88MP0001663_abnormal_digestive_system0.89732719
89MP0003300_gastrointestinal_ulcer0.89405997
90MP0010030_abnormal_orbit_morphology0.88813190
91MP0002722_abnormal_immune_system0.88580038
92MP0005266_abnormal_metabolism0.85590296
93MP0001756_abnormal_urination0.84744522
94MP0005167_abnormal_blood-brain_barrier0.83542770
95MP0005376_homeostasis/metabolism_phenot0.82857934
96MP0008469_abnormal_protein_level0.78667911
97MP0009642_abnormal_blood_homeostasis0.78223092
98MP0002876_abnormal_thyroid_physiology0.77225205
99MP0002132_abnormal_respiratory_system0.76770257
100MP0005174_abnormal_tail_pigmentation0.76443417
101MP0003690_abnormal_glial_cell0.75319019
102MP0001986_abnormal_taste_sensitivity0.75142519
103MP0009765_abnormal_xenobiotic_induced0.74970745
104MP0000604_amyloidosis0.74180645
105MP0002933_joint_inflammation0.73587839
106MP0003638_abnormal_response/metabolism_0.72572323
107MP0002136_abnormal_kidney_physiology0.70503925
108MP0008872_abnormal_physiological_respon0.70401891
109MP0002971_abnormal_brown_adipose0.69601352
110MP0005075_abnormal_melanosome_morpholog0.69196822
111MP0005248_abnormal_Harderian_gland0.68673172
112MP0006036_abnormal_mitochondrial_physio0.68569090
113MP0000858_altered_metastatic_potential0.68143622
114MP0004947_skin_inflammation0.67500654
115MP0005334_abnormal_fat_pad0.67476704
116MP0004264_abnormal_extraembryonic_tissu0.67459970
117MP0004782_abnormal_surfactant_physiolog0.64446910
118MP0003718_maternal_effect0.63257750
119MP0005535_abnormal_body_temperature0.63213170
120MP0002078_abnormal_glucose_homeostasis0.61026997
121MP0006082_CNS_inflammation0.58198066
122MP0003878_abnormal_ear_physiology0.57993454
123MP0005377_hearing/vestibular/ear_phenot0.57993454
124MP0002928_abnormal_bile_duct0.56414628
125MP0003724_increased_susceptibility_to0.56236491
126MP0005395_other_phenotype0.54347332
127MP0009115_abnormal_fat_cell0.52613479
128MP0003453_abnormal_keratinocyte_physiol0.51958246
129MP0001346_abnormal_lacrimal_gland0.50996066
130MP0003436_decreased_susceptibility_to0.49642211
131MP0005220_abnormal_exocrine_pancreas0.49129726
132MP0003075_altered_response_to0.46434141
133MP0004130_abnormal_muscle_cell0.46117810
134MP0002877_abnormal_melanocyte_morpholog0.46039080
135MP0005166_decreased_susceptibility_to0.45340503
136MP0005023_abnormal_wound_healing0.45043899
137MP0004883_abnormal_blood_vessel0.43786672
138MP0005464_abnormal_platelet_physiology0.43212957
139MP0005164_abnormal_response_to0.41971286
140MP0002295_abnormal_pulmonary_circulatio0.41003060
141MP0000678_abnormal_parathyroid_gland0.40988628
142MP0000566_synostosis0.39466466
143MP0005666_abnormal_adipose_tissue0.39437694
144MP0010234_abnormal_vibrissa_follicle0.37792051
145MP0002249_abnormal_larynx_morphology0.37081943
146MP0002060_abnormal_skin_morphology0.36996026
147MP0005448_abnormal_energy_balance0.36935128
148MP0000613_abnormal_salivary_gland0.36799812
149MP0003953_abnormal_hormone_level0.36671944
150MP0008873_increased_physiological_sensi0.35750949
151MP0001881_abnormal_mammary_gland0.35450324
152MP0002135_abnormal_kidney_morphology0.34600244
153MP0002098_abnormal_vibrissa_morphology0.34350416

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.64023569
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.58761552
3Deep venous thrombosis (HP:0002625)6.56691073
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.23666303
5Hypobetalipoproteinemia (HP:0003563)5.81995682
6Xanthomatosis (HP:0000991)5.66029660
7Prolonged partial thromboplastin time (HP:0003645)5.55869690
8Hyperglycinuria (HP:0003108)4.60800078
9Hyperlipoproteinemia (HP:0010980)4.58412096
10Complement deficiency (HP:0004431)4.54935912
11Abnormality of glycolipid metabolism (HP:0010969)4.54612532
12Abnormality of liposaccharide metabolism (HP:0010968)4.54612532
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.54612532
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.48665181
15Hypolipoproteinemia (HP:0010981)4.42540395
16Hyperammonemia (HP:0001987)4.37398476
17Vacuolated lymphocytes (HP:0001922)4.33492675
18Hyperglycinemia (HP:0002154)4.26754405
19Fat malabsorption (HP:0002630)4.23637716
20Abnormality of glycine metabolism (HP:0010895)4.19815113
21Abnormality of serine family amino acid metabolism (HP:0010894)4.19815113
22Ketosis (HP:0001946)4.16000878
23Conjugated hyperbilirubinemia (HP:0002908)4.11645535
24Joint hemorrhage (HP:0005261)4.11284018
25Abnormality of aspartate family amino acid metabolism (HP:0010899)4.07259678
26Abnormality of sulfur amino acid metabolism (HP:0004339)4.03928331
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.99502051
28Epidermoid cyst (HP:0200040)3.98926977
29Hypoalphalipoproteinemia (HP:0003233)3.85669746
30Abnormality of methionine metabolism (HP:0010901)3.81945852
31Abnormality of fatty-acid metabolism (HP:0004359)3.79504838
32Abnormality of the common coagulation pathway (HP:0010990)3.75804985
33Abnormality of macrophages (HP:0004311)3.71804188
34Hypoglycemic coma (HP:0001325)3.68814348
35Hypercholesterolemia (HP:0003124)3.52851126
36Abnormality of pyrimidine metabolism (HP:0004353)3.45795521
37Abnormality of complement system (HP:0005339)3.42780490
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.34144531
39T lymphocytopenia (HP:0005403)3.26371214
40Ketoacidosis (HP:0001993)3.26334443
41Steatorrhea (HP:0002570)3.24509516
42Abnormality of T cell number (HP:0011839)3.23296629
43Hyperbilirubinemia (HP:0002904)3.21702928
44Purpura (HP:0000979)3.21223445
45Abnormality of the intrinsic pathway (HP:0010989)3.20559739
46Abnormality of nucleobase metabolism (HP:0010932)3.18724864
47Elevated erythrocyte sedimentation rate (HP:0003565)3.08209559
48Hepatocellular carcinoma (HP:0001402)3.05881012
49Abnormality of purine metabolism (HP:0004352)3.05189535
50Myocardial infarction (HP:0001658)2.99038238
51Petechiae (HP:0000967)2.96145614
52Abnormality of serum amino acid levels (HP:0003112)2.93543605
53Metabolic acidosis (HP:0001942)2.91665008
54Autoimmune hemolytic anemia (HP:0001890)2.90438216
55Delayed CNS myelination (HP:0002188)2.86192150
56Chronic diarrhea (HP:0002028)2.84698456
57Gout (HP:0001997)2.84302193
58Eczematoid dermatitis (HP:0000976)2.82805249
59Joint swelling (HP:0001386)2.81683188
60Dicarboxylic aciduria (HP:0003215)2.76481215
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.76481215
62Systemic lupus erythematosus (HP:0002725)2.73895310
63Abnormality of T cells (HP:0002843)2.71084490
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70383542
65Abnormality of alanine metabolism (HP:0010916)2.70383542
66Hyperalaninemia (HP:0003348)2.70383542
67Lethargy (HP:0001254)2.69784040
68Generalized aminoaciduria (HP:0002909)2.68086178
69Recurrent cutaneous fungal infections (HP:0011370)2.65532204
70Chronic mucocutaneous candidiasis (HP:0002728)2.65532204
71Stomatitis (HP:0010280)2.64733638
72Vascular calcification (HP:0004934)2.62007223
73Increased cerebral lipofuscin (HP:0011813)2.57059046
74Malnutrition (HP:0004395)2.56432433
75Proximal tubulopathy (HP:0000114)2.56131335
76Abnormal delayed hypersensitivity skin test (HP:0002963)2.52274688
77Dysostosis multiplex (HP:0000943)2.51182918
78Recurrent abscess formation (HP:0002722)2.49688472
79Spastic diplegia (HP:0001264)2.47360151
80Esophageal varix (HP:0002040)2.45471715
81Spontaneous abortion (HP:0005268)2.43629964
82Congenital sensorineural hearing impairment (HP:0008527)2.42675584
83Retrobulbar optic neuritis (HP:0100654)2.37257769
84Optic neuritis (HP:0100653)2.37257769
85Autoimmune thrombocytopenia (HP:0001973)2.35753748
86Recurrent bacterial skin infections (HP:0005406)2.35121378
87Hydroxyprolinuria (HP:0003080)2.35051592
88Abnormality of proline metabolism (HP:0010907)2.35051592
89Pulmonary embolism (HP:0002204)2.33850468
90Recurrent fungal infections (HP:0002841)2.33126571
91Increased serum pyruvate (HP:0003542)2.33118382
92Hypochromic microcytic anemia (HP:0004840)2.32484184
93Renal cortical cysts (HP:0000803)2.32346110
94Pulmonary infiltrates (HP:0002113)2.31479420
95Cardiovascular calcification (HP:0011915)2.31438294
96Renal tubular acidosis (HP:0001947)2.30436717
97Increased IgM level (HP:0003496)2.29895200
98Myositis (HP:0100614)2.29761144
99Pancreatitis (HP:0001733)2.29056536
100Acanthocytosis (HP:0001927)2.26658329
101Recurrent skin infections (HP:0001581)2.25524920
102IgG deficiency (HP:0004315)2.22220715
103Glycosuria (HP:0003076)2.20925593
104Abnormality of urine glucose concentration (HP:0011016)2.20925593
105Irritability (HP:0000737)2.20442827
106Anorexia (HP:0002039)2.19656424
107Abnormality of polysaccharide metabolism (HP:0011012)2.19352453
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19352453
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19352453
110Sensorimotor neuropathy (HP:0007141)2.19147339
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.18854131
112Rickets (HP:0002748)2.18782347
113Orchitis (HP:0100796)2.17882021
114Vasculitis (HP:0002633)2.17570385
115Skin nodule (HP:0200036)2.17159986
116Spontaneous hematomas (HP:0007420)2.17075689
117Vomiting (HP:0002013)2.16238059
118Cerebral edema (HP:0002181)2.14781977
119Abnormal cartilage morphology (HP:0002763)2.13437284
120Abnormal gallbladder morphology (HP:0012437)2.12600295
121Hemoptysis (HP:0002105)2.12460363
122Alkalosis (HP:0001948)2.11993226
123Amyloidosis (HP:0011034)2.11701299
124Cholelithiasis (HP:0001081)2.08853859
125Increased purine levels (HP:0004368)2.08825811
126Hyperuricemia (HP:0002149)2.08825811
127Pustule (HP:0200039)2.08237700
128Encephalitis (HP:0002383)2.08094729
129Metaphyseal irregularity (HP:0003025)2.07802186
130Obstructive lung disease (HP:0006536)2.07688805
131Chronic obstructive pulmonary disease (HP:0006510)2.07688805
132Epistaxis (HP:0000421)2.07103509
133Urinary glycosaminoglycan excretion (HP:0003541)2.05890952
134Mucopolysacchariduria (HP:0008155)2.05890952
135Abnormality of glycolysis (HP:0004366)2.03837088
136Polyneuropathy (HP:0001271)2.03479250
137Neonatal onset (HP:0003623)2.03150740
138Abnormality of eosinophils (HP:0001879)2.02698065
139Recurrent gram-negative bacterial infections (HP:0005420)2.01462791
140Opisthotonus (HP:0002179)2.00244664
141Abnormality of the prostate (HP:0008775)1.99649317
142Hypoglycemic seizures (HP:0002173)1.99515041
143Abnormality of vitamin metabolism (HP:0100508)1.98813583
144Nephritis (HP:0000123)1.98150484
145Abnormal tarsal ossification (HP:0008369)1.96044295
146Glomerulonephritis (HP:0000099)1.96042049
147Nausea (HP:0002018)1.95960389
148Increased serum ferritin (HP:0003281)1.95753997
149Aplastic anemia (HP:0001915)1.94911542
150Enlarged kidneys (HP:0000105)1.94154403
151Mitral stenosis (HP:0001718)1.93614920
152Thrombophlebitis (HP:0004418)1.93169209
153Pigmentary retinal degeneration (HP:0001146)1.92666853
154Disinhibition (HP:0000734)1.91145397
155Cholecystitis (HP:0001082)1.91118920
156Abnormal gallbladder physiology (HP:0012438)1.91118920
157Brushfield spots (HP:0001088)1.90156236
158Gingival bleeding (HP:0000225)1.89706818
159Meningitis (HP:0001287)1.89274544
160Ileus (HP:0002595)1.88839720
161Hypertriglyceridemia (HP:0002155)1.88801562
162Hepatosplenomegaly (HP:0001433)1.88454142
163Abnormal enzyme/coenzyme activity (HP:0012379)1.88106164
164Abnormality of T cell physiology (HP:0011840)1.87651778
165Late onset (HP:0003584)1.86130740
166Polycythemia (HP:0001901)1.85995145
167Elevated hepatic transaminases (HP:0002910)1.84014662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.69477513
2BCKDK6.17166830
3MAP4K14.10603198
4ACVR1B3.90497678
5ERN13.71133418
6FGFR43.52350291
7SIK13.00135219
8FRK2.86449522
9MAP3K32.59835058
10PBK2.39023809
11ERBB42.32724638
12PKN22.28572899
13MST1R2.14118693
14TRIB32.09386426
15MAP2K32.08860062
16ADRBK22.07284343
17RIPK42.04229065
18STK38L1.93953330
19TESK21.86056022
20INSRR1.81032252
21BLK1.78665001
22LATS11.75045815
23TAOK31.71609925
24MAPK151.59494764
25ITK1.58863840
26GRK71.58341987
27IRAK41.54298792
28ZAP701.52226867
29TAOK21.50671255
30TYK21.49854585
31RIPK11.43450973
32ZAK1.38383187
33MATK1.36795767
34MAP3K111.35677210
35EPHA31.35516861
36IRAK31.34512183
37NEK91.29789167
38MAPK111.29056009
39FGR1.25663921
40MST41.25522078
41MAP2K61.24114703
42EPHB11.23586745
43FLT31.22644748
44MAP2K21.17227636
45SYK1.14129752
46LYN1.13884548
47PTK61.13866050
48MAP3K141.13823407
49LCK1.13675425
50TBK11.11095329
51CAMKK21.08124933
52TAOK11.07896669
53ABL21.07638318
54PRKCQ1.07402799
55CDK61.06258223
56RPS6KB21.04035410
57MAP2K41.00905862
58PINK11.00547207
59EPHA20.97737100
60ERBB20.96398943
61FES0.96045995
62PRKAA20.95227760
63JAK20.94861637
64PIK3CG0.94405764
65NLK0.89521561
66MAP3K20.88374804
67JAK10.87026168
68GRK10.85927693
69SGK20.84989322
70TRIM280.83881607
71STK100.83806684
72MAP3K70.82146059
73SGK30.81372423
74TEC0.81279204
75IKBKE0.80796737
76CSF1R0.80741073
77MAPKAPK30.80224408
78GRK60.79436813
79TLK10.77003739
80MAP2K10.76798735
81BMPR1B0.75566916
82KDR0.74645432
83NUAK10.74468522
84BTK0.74393263
85STK40.72869470
86OXSR10.72150742
87MARK30.70948819
88KIT0.70020941
89PDK40.69910540
90PDK30.69910540
91EPHB20.67834330
92MAP3K50.67405407
93BMPR20.67261712
94HCK0.66173563
95MET0.65337624
96FGFR30.64888939
97NME20.61316901
98WNK40.60379617
99SGK2230.60018902
100SGK4940.60018902
101IGF1R0.59728740
102PDK20.58194302
103PAK30.56998573
104MAPK40.56664974
105GSK3A0.55935950
106WNK30.54601911
107MAP3K10.53308667
108EIF2AK10.52829230
109EIF2AK30.52458265
110AKT30.50059422
111LRRK20.49462177
112STK390.49273955
113LATS20.48924534
114PIK3CA0.48807026
115TRPM70.48776135
116PRKCZ0.48517073
117TIE10.47809554
118TGFBR20.47549262
119CHUK0.47308563
120TNIK0.46016458
121IRAK10.43887666
122TESK10.43865199
123CSK0.43497300
124FER0.42285205
125PRKAA10.41272498
126MYLK0.41250325
127JAK30.41217779
128PDPK10.40921915
129PRKG20.39483570
130TTK0.38864986
131STK30.38165739
132MAP3K60.37879394
133STK380.37287847
134PRKCD0.37147148
135LMTK20.36986372
136CAMK2G0.36727360
137CSNK2A10.36422556
138MAPK70.36199988
139PDK10.35695738
140PRKACG0.35505623
141CSNK1A10.34800946
142IKBKB0.34616360
143STK160.34468162
144ADRBK10.34184991
145MAPKAPK20.33536950
146PRKCA0.32714300
147FYN0.31832401
148MAP3K120.30408750
149MAP3K80.29608976
150VRK10.27968108

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.22173189
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.78799027
3Pentose and glucuronate interconversions_Homo sapiens_hsa000403.62782377
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.96127297
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.77190902
6Nitrogen metabolism_Homo sapiens_hsa009102.76274367
7Chemical carcinogenesis_Homo sapiens_hsa052042.63063734
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.56291881
9Arginine biosynthesis_Homo sapiens_hsa002202.42017553
10Fatty acid degradation_Homo sapiens_hsa000712.37813048
11Tryptophan metabolism_Homo sapiens_hsa003802.36243790
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.34086560
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27939067
14Butanoate metabolism_Homo sapiens_hsa006502.24992425
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23728688
16Other glycan degradation_Homo sapiens_hsa005112.18843995
17Sulfur metabolism_Homo sapiens_hsa009202.16949975
18Complement and coagulation cascades_Homo sapiens_hsa046102.16764109
19Graft-versus-host disease_Homo sapiens_hsa053322.16163970
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.15540920
21Allograft rejection_Homo sapiens_hsa053302.14791404
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14346740
23Antigen processing and presentation_Homo sapiens_hsa046122.14220126
24Drug metabolism - other enzymes_Homo sapiens_hsa009832.09493043
25Autoimmune thyroid disease_Homo sapiens_hsa053202.07005216
26Peroxisome_Homo sapiens_hsa041462.05306759
27Retinol metabolism_Homo sapiens_hsa008301.96859619
28Primary immunodeficiency_Homo sapiens_hsa053401.94342565
29Propanoate metabolism_Homo sapiens_hsa006401.89962195
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89610348
31Histidine metabolism_Homo sapiens_hsa003401.83931900
32Caffeine metabolism_Homo sapiens_hsa002321.81616200
33Asthma_Homo sapiens_hsa053101.80036973
34Lysosome_Homo sapiens_hsa041421.77300254
35beta-Alanine metabolism_Homo sapiens_hsa004101.75578828
36Starch and sucrose metabolism_Homo sapiens_hsa005001.75522016
37PPAR signaling pathway_Homo sapiens_hsa033201.67945467
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59604498
39Fatty acid metabolism_Homo sapiens_hsa012121.59068921
40Rheumatoid arthritis_Homo sapiens_hsa053231.59020828
41Proteasome_Homo sapiens_hsa030501.56744888
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.54656767
43Sulfur relay system_Homo sapiens_hsa041221.54322357
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.49336412
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45157680
46Hematopoietic cell lineage_Homo sapiens_hsa046401.44874132
47Type I diabetes mellitus_Homo sapiens_hsa049401.44122446
48Selenocompound metabolism_Homo sapiens_hsa004501.42792425
49Phenylalanine metabolism_Homo sapiens_hsa003601.38474120
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37804572
51Glutathione metabolism_Homo sapiens_hsa004801.35729337
52Staphylococcus aureus infection_Homo sapiens_hsa051501.35151788
53Bile secretion_Homo sapiens_hsa049761.34524183
54Collecting duct acid secretion_Homo sapiens_hsa049661.33441196
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31057732
56Tyrosine metabolism_Homo sapiens_hsa003501.29319328
57Pyruvate metabolism_Homo sapiens_hsa006201.28833047
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27611973
59Folate biosynthesis_Homo sapiens_hsa007901.26460282
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.22446627
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19364684
62Fat digestion and absorption_Homo sapiens_hsa049751.14356564
63ABC transporters_Homo sapiens_hsa020101.13306083
64Carbon metabolism_Homo sapiens_hsa012001.04692944
65Cyanoamino acid metabolism_Homo sapiens_hsa004601.04218951
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01973476
67Vitamin digestion and absorption_Homo sapiens_hsa049770.98285509
68Biosynthesis of amino acids_Homo sapiens_hsa012300.97900971
69Fatty acid elongation_Homo sapiens_hsa000620.96871457
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.96434268
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94832083
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93900856
73Arginine and proline metabolism_Homo sapiens_hsa003300.92519824
74Steroid biosynthesis_Homo sapiens_hsa001000.91144290
75Oxidative phosphorylation_Homo sapiens_hsa001900.88539401
76* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85951152
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84990163
78Leishmaniasis_Homo sapiens_hsa051400.82484862
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80610611
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.79765538
81Glycerolipid metabolism_Homo sapiens_hsa005610.78729555
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75263113
83One carbon pool by folate_Homo sapiens_hsa006700.73099347
84Measles_Homo sapiens_hsa051620.68745349
85Osteoclast differentiation_Homo sapiens_hsa043800.68222456
86Lysine degradation_Homo sapiens_hsa003100.66365722
87Pentose phosphate pathway_Homo sapiens_hsa000300.63265821
88Phagosome_Homo sapiens_hsa041450.61710244
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61152531
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59202649
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58528331
92Tuberculosis_Homo sapiens_hsa051520.57666320
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57506650
94T cell receptor signaling pathway_Homo sapiens_hsa046600.55310401
95Vitamin B6 metabolism_Homo sapiens_hsa007500.51649588
96Viral myocarditis_Homo sapiens_hsa054160.50189462
97Ether lipid metabolism_Homo sapiens_hsa005650.50115707
98Sphingolipid metabolism_Homo sapiens_hsa006000.50093678
99* Metabolic pathways_Homo sapiens_hsa011000.43922236
100Fatty acid biosynthesis_Homo sapiens_hsa000610.42978700
101Fructose and mannose metabolism_Homo sapiens_hsa000510.37785372
102Prion diseases_Homo sapiens_hsa050200.36569394
103* Galactose metabolism_Homo sapiens_hsa000520.31102605
104Insulin resistance_Homo sapiens_hsa049310.20400522
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20311461
106Linoleic acid metabolism_Homo sapiens_hsa005910.16870848
107Mineral absorption_Homo sapiens_hsa049780.14336646
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.12102334
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07249629
110Arachidonic acid metabolism_Homo sapiens_hsa005900.03793285
111Renin-angiotensin system_Homo sapiens_hsa046140.03784424
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.00337872
113TNF signaling pathway_Homo sapiens_hsa04668-0.1870079
114Insulin signaling pathway_Homo sapiens_hsa04910-0.1856350
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1784527
116Circadian rhythm_Homo sapiens_hsa04710-0.1757881
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1754971
118Legionellosis_Homo sapiens_hsa05134-0.1561903
119Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1539440
120Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1487719
121Protein digestion and absorption_Homo sapiens_hsa04974-0.1307433
122Pertussis_Homo sapiens_hsa05133-0.1271553
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1209576
124Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1017860
125Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0872313
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0867713
127Hepatitis C_Homo sapiens_hsa05160-0.0724641
128AMPK signaling pathway_Homo sapiens_hsa04152-0.0715473
129Glucagon signaling pathway_Homo sapiens_hsa04922-0.0608372
130African trypanosomiasis_Homo sapiens_hsa05143-0.0254879
131Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0144513
132Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0134437

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