GALE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.76679933
2Golgi transport vesicle coating (GO:0048200)5.76679933
3intestinal absorption (GO:0050892)4.99735911
4intestinal cholesterol absorption (GO:0030299)4.87399659
5UDP-N-acetylglucosamine metabolic process (GO:0006047)4.68791645
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.64376165
7protein retention in ER lumen (GO:0006621)4.58025504
8sulfur amino acid catabolic process (GO:0000098)4.56679154
9GDP-mannose metabolic process (GO:0019673)4.55643608
10nucleotide-sugar biosynthetic process (GO:0009226)4.51003820
11intestinal epithelial cell development (GO:0060576)4.13405997
123-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.11855530
13purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.11855530
14COPII vesicle coating (GO:0048208)3.93779203
15proteasome assembly (GO:0043248)3.82343934
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.74554684
17proline biosynthetic process (GO:0006561)3.73658374
184-hydroxyproline metabolic process (GO:0019471)3.67997984
19nucleotide-sugar metabolic process (GO:0009225)3.59930338
20pyrimidine-containing compound transmembrane transport (GO:0072531)3.58161140
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.51953061
22L-phenylalanine metabolic process (GO:0006558)3.51953061
23regulation of mitochondrial translation (GO:0070129)3.51292821
24desmosome organization (GO:0002934)3.47558405
25bile acid and bile salt transport (GO:0015721)3.46848867
26transcytosis (GO:0045056)3.35239019
27protein autoprocessing (GO:0016540)3.35115061
28regulation of cholesterol homeostasis (GO:2000188)3.30590996
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.28087794
30L-serine metabolic process (GO:0006563)3.26859805
31regulation of cellular amino acid metabolic process (GO:0006521)3.25207672
32L-phenylalanine catabolic process (GO:0006559)3.24794222
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.24794222
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20576050
35negative regulation of cholesterol transport (GO:0032375)3.16646571
36negative regulation of sterol transport (GO:0032372)3.16646571
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14351345
38oxidative phosphorylation (GO:0006119)3.13381826
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.13115739
40signal peptide processing (GO:0006465)3.13007833
41primary alcohol catabolic process (GO:0034310)3.11905602
42proline metabolic process (GO:0006560)3.09501494
43nucleotide salvage (GO:0043173)3.08962901
44glutamine family amino acid biosynthetic process (GO:0009084)3.08334289
45protein maturation by protein folding (GO:0022417)3.07820339
46mitotic nuclear envelope reassembly (GO:0007084)3.06941437
47nuclear envelope reassembly (GO:0031468)3.06941437
48nucleobase-containing small molecule interconversion (GO:0015949)3.06719605
49nucleoside bisphosphate metabolic process (GO:0033865)3.05895564
50purine nucleoside bisphosphate metabolic process (GO:0034032)3.05895564
51ribonucleoside bisphosphate metabolic process (GO:0033875)3.05895564
52homocysteine metabolic process (GO:0050667)3.05628303
53cysteine metabolic process (GO:0006534)3.05396849
54nucleoside diphosphate biosynthetic process (GO:0009133)3.04395801
55cellular glucuronidation (GO:0052695)3.01276937
56lipopolysaccharide biosynthetic process (GO:0009103)2.99872084
57high-density lipoprotein particle remodeling (GO:0034375)2.99305884
58ethanol metabolic process (GO:0006067)2.98326543
59alpha-linolenic acid metabolic process (GO:0036109)2.98000245
60acylglycerol homeostasis (GO:0055090)2.97342713
61triglyceride homeostasis (GO:0070328)2.97342713
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.96727103
63maintenance of gastrointestinal epithelium (GO:0030277)2.96689940
64folic acid-containing compound biosynthetic process (GO:0009396)2.96503103
65negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93439835
66negative regulation of ligase activity (GO:0051352)2.93439835
67activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.93104683
68serine family amino acid biosynthetic process (GO:0009070)2.91519772
69positive regulation of nuclease activity (GO:0032075)2.89841189
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89153526
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88035117
72purine nucleotide salvage (GO:0032261)2.87807712
73cellular ketone body metabolic process (GO:0046950)2.86818069
74nucleoside salvage (GO:0043174)2.86628846
75pteridine-containing compound biosynthetic process (GO:0042559)2.86334536
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86161039
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85971545
78pentose-phosphate shunt (GO:0006098)2.84479482
79positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82899099
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.80480149
81signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.80480149
82positive regulation of triglyceride lipase activity (GO:0061365)2.80264094
83positive regulation of lipoprotein lipase activity (GO:0051006)2.80264094
84glucose 6-phosphate metabolic process (GO:0051156)2.79680948
85endocrine pancreas development (GO:0031018)2.77867542
86glucuronate metabolic process (GO:0019585)2.77545025
87uronic acid metabolic process (GO:0006063)2.77545025
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76589199
89regulation of triglyceride catabolic process (GO:0010896)2.76363987
90tricarboxylic acid cycle (GO:0006099)2.76124948
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76106721
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76106721
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76106721
94mitochondrial calcium ion transport (GO:0006851)2.75925778
95telomere maintenance via semi-conservative replication (GO:0032201)2.75365753
96reverse cholesterol transport (GO:0043691)2.75351078
97flavonoid metabolic process (GO:0009812)2.73150160
98DNA strand elongation involved in DNA replication (GO:0006271)2.73136492
99phospholipid efflux (GO:0033700)2.72805416
100digestive system process (GO:0022600)2.72109433
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.72051713
102signal transduction involved in DNA integrity checkpoint (GO:0072401)2.72051713
103drug catabolic process (GO:0042737)2.69637776
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.68457103
105regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.67953356
106establishment of viral latency (GO:0019043)2.67153917
107aromatic amino acid family catabolic process (GO:0009074)2.66821681
108signal transduction involved in cell cycle checkpoint (GO:0072395)2.66778780
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66218327
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66218327
111lipoprotein metabolic process (GO:0042157)2.66199646
112digestion (GO:0007586)2.66149421
113regulation of translational fidelity (GO:0006450)2.65628179
114regulation of nuclease activity (GO:0032069)2.65002498
115establishment of integrated proviral latency (GO:0075713)2.63384279
116DNA strand elongation (GO:0022616)2.63257095
117purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.62703257
118ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.62703257
119nucleoside bisphosphate biosynthetic process (GO:0033866)2.62703257
120protein-lipid complex remodeling (GO:0034368)2.62641721
121macromolecular complex remodeling (GO:0034367)2.62641721
122plasma lipoprotein particle remodeling (GO:0034369)2.62641721
123regulation of metalloenzyme activity (GO:0048552)2.62183144
124endoplasmic reticulum unfolded protein response (GO:0030968)2.61559076
125mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.61183319
126NADPH regeneration (GO:0006740)2.60886406
127positive regulation of triglyceride metabolic process (GO:0090208)2.60042824
128activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.59559638
129protein N-linked glycosylation via asparagine (GO:0018279)2.57976558
130valine metabolic process (GO:0006573)2.57671054
131lysine catabolic process (GO:0006554)2.57306009
132lysine metabolic process (GO:0006553)2.57306009
133fatty acid beta-oxidation (GO:0006635)2.57279943
134positive regulation of ligase activity (GO:0051351)2.56863615
135glutathione biosynthetic process (GO:0006750)2.56795116
136plasma lipoprotein particle assembly (GO:0034377)2.56283713
137peptidyl-asparagine modification (GO:0018196)2.55293860
138pyrimidine nucleoside catabolic process (GO:0046135)2.55023950
139NADH metabolic process (GO:0006734)2.54355987
140regulation of proton transport (GO:0010155)2.54116312
141urea metabolic process (GO:0019627)2.53750471
142urea cycle (GO:0000050)2.53750471
143cellular response to unfolded protein (GO:0034620)2.53571064
144pyrimidine-containing compound salvage (GO:0008655)2.53435005
145pyrimidine nucleoside salvage (GO:0043097)2.53435005
146ribosome biogenesis (GO:0042254)2.51682803
147guanosine-containing compound biosynthetic process (GO:1901070)2.50453371
148mitochondrial RNA metabolic process (GO:0000959)2.49432763
149protein targeting to mitochondrion (GO:0006626)2.49001427
150daunorubicin metabolic process (GO:0044597)2.47743918
151polyketide metabolic process (GO:0030638)2.47743918
152doxorubicin metabolic process (GO:0044598)2.47743918
153regulation of cellular amine metabolic process (GO:0033238)2.47211704
154tRNA aminoacylation for protein translation (GO:0006418)2.46816418
155de novo posttranslational protein folding (GO:0051084)2.46732168
156glycosphingolipid catabolic process (GO:0046479)2.46135464
157folic acid metabolic process (GO:0046655)2.45348952
158gluconeogenesis (GO:0006094)2.44990255
159monosaccharide biosynthetic process (GO:0046364)2.43567649
160aminoglycoside antibiotic metabolic process (GO:0030647)2.43442050
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.43410265
162cellular copper ion homeostasis (GO:0006878)2.42883109
163glycoside metabolic process (GO:0016137)2.40870729
164base-excision repair, AP site formation (GO:0006285)2.40294727
165pseudouridine synthesis (GO:0001522)2.40039174
166de novo protein folding (GO:0006458)2.40031711
167nonribosomal peptide biosynthetic process (GO:0019184)2.39317485
168amino acid activation (GO:0043038)2.37628922
169tRNA aminoacylation (GO:0043039)2.37628922
170rRNA modification (GO:0000154)2.37353308
171regulation of ubiquitin-protein transferase activity (GO:0051438)2.36980737
172hexose biosynthetic process (GO:0019319)2.36588605
173nucleoside transmembrane transport (GO:1901642)2.34431570
174glycolipid catabolic process (GO:0019377)2.34223622
175mitochondrial fusion (GO:0008053)2.34218518
176alpha-amino acid biosynthetic process (GO:1901607)2.32545311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.09713995
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.01696199
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.97324212
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.43677261
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.39888768
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15612171
7E2F7_22180533_ChIP-Seq_HELA_Human2.86811677
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.83534313
9HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.65219944
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.44039572
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.25800177
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25685630
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.20233056
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12445372
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.10140510
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07410346
17SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95984630
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91985400
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90915274
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90231611
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.86796197
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83621953
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.81206589
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77527151
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74417541
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73624696
27* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73041595
28GATA4_25053715_ChIP-Seq_YYC3_Human1.72794296
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70277206
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68118199
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67721695
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65457984
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.64217528
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61726131
35CDX2_20551321_ChIP-Seq_CACO-2_Human1.57300883
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.57034153
37* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56580074
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.56017202
39* GATA6_25053715_ChIP-Seq_YYC3_Human1.54258165
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54100318
41* ATF3_27146783_Chip-Seq_COLON_Human1.50574734
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49401766
43DCP1A_22483619_ChIP-Seq_HELA_Human1.47456827
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.46099565
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43309870
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42214090
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39791754
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38337204
49GABP_19822575_ChIP-Seq_HepG2_Human1.38155710
50* SOX2_20726797_ChIP-Seq_SW620_Human1.35959323
51XRN2_22483619_ChIP-Seq_HELA_Human1.35257016
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34591643
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.34453630
54CLOCK_20551151_ChIP-Seq_293T_Human1.33566359
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33227733
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.32174894
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30745533
58KDM5A_27292631_Chip-Seq_BREAST_Human1.29315034
59TTF2_22483619_ChIP-Seq_HELA_Human1.28153824
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24305148
61* RACK7_27058665_Chip-Seq_MCF-7_Human1.24263152
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23810261
63ZNF263_19887448_ChIP-Seq_K562_Human1.22598648
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.21893749
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20437723
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20143205
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.19646955
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18388040
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15773162
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15194811
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13567657
72P68_20966046_ChIP-Seq_HELA_Human1.12832263
73ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12437464
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.12362745
75OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11998321
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11857204
77CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11659056
78GATA1_22025678_ChIP-Seq_K562_Human1.11177328
79AR_21909140_ChIP-Seq_LNCAP_Human1.09951133
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.08721809
81* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08588935
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08069822
83LXR_22292898_ChIP-Seq_THP-1_Human1.05677434
84BCOR_27268052_Chip-Seq_Bcells_Human1.04556570
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04475454
86TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04371357
87* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04122907
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03814349
89ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03556873
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.02991480
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02720739
92* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01976916
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01976315
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01697092
95PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00801775
96SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00284050
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00273450
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.99834123
99NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.99303703
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98353762
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98314126
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98241811
103ESR1_21235772_ChIP-Seq_MCF-7_Human0.98135287
104E2F1_21310950_ChIP-Seq_MCF-7_Human0.98125200
105PHF8_20622854_ChIP-Seq_HELA_Human0.97600241
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97131406
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95870360
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95257425
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95237420
110TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94913802
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94454174
112YY1_21170310_ChIP-Seq_MESCs_Mouse0.94393410
113VDR_23849224_ChIP-Seq_CD4+_Human0.94272020
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93932423
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93606254
116P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93404094
117SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92601569
118* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92530453
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.91610338
120* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90837810
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.90684381
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.88994809
123* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88666385
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87811425
125YY1_22570637_ChIP-Seq_MALME-3M_Human0.87775737
126* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87536930
127THAP11_20581084_ChIP-Seq_MESCs_Mouse0.87347202
128* FOXP3_21729870_ChIP-Seq_TREG_Human0.86878754

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.29170637
2MP0005360_urolithiasis4.77437511
3MP0003806_abnormal_nucleotide_metabolis4.16228975
4MP0005365_abnormal_bile_salt3.80085159
5MP0001666_abnormal_nutrient_absorption3.79115942
6MP0005085_abnormal_gallbladder_physiolo3.77333711
7MP0004264_abnormal_extraembryonic_tissu3.37985616
8MP0005083_abnormal_biliary_tract3.00126416
9MP0010234_abnormal_vibrissa_follicle2.97613318
10MP0003283_abnormal_digestive_organ2.87347041
11MP0009840_abnormal_foam_cell2.47709190
12MP0003693_abnormal_embryo_hatching2.40115684
13MP0010030_abnormal_orbit_morphology2.37533899
14MP0008875_abnormal_xenobiotic_pharmacok2.28358644
15MP0003252_abnormal_bile_duct2.21096040
16MP0000462_abnormal_digestive_system2.15157004
17MP0010329_abnormal_lipoprotein_level2.14510861
18MP0005408_hypopigmentation2.14337830
19MP0003866_abnormal_defecation2.04202151
20MP0009643_abnormal_urine_homeostasis1.80561214
21MP0001873_stomach_inflammation1.76603008
22MP0005220_abnormal_exocrine_pancreas1.75872254
23MP0003111_abnormal_nucleus_morphology1.74988040
24MP0003705_abnormal_hypodermis_morpholog1.73183844
25MP0005381_digestive/alimentary_phenotyp1.66205308
26MP0005332_abnormal_amino_acid1.65527261
27MP0001663_abnormal_digestive_system1.63792253
28MP0008932_abnormal_embryonic_tissue1.61525171
29MP0003786_premature_aging1.61307960
30MP0001664_abnormal_digestion1.57469076
31MP0005257_abnormal_intraocular_pressure1.54511097
32MP0003868_abnormal_feces_composition1.54384346
33MP0003191_abnormal_cellular_cholesterol1.54120651
34MP0000609_abnormal_liver_physiology1.52883973
35MP0002098_abnormal_vibrissa_morphology1.50729879
36MP0003300_gastrointestinal_ulcer1.50719771
37MP0002796_impaired_skin_barrier1.50535997
38MP0000490_abnormal_crypts_of1.44905737
39MP0005084_abnormal_gallbladder_morpholo1.44113767
40MP0001764_abnormal_homeostasis1.43641305
41MP0004019_abnormal_vitamin_homeostasis1.43037230
42MP0000477_abnormal_intestine_morphology1.42550363
43MP0000358_abnormal_cell_content/1.41675281
44MP0005636_abnormal_mineral_homeostasis1.41622723
45MP0002909_abnormal_adrenal_gland1.40960471
46MP0003077_abnormal_cell_cycle1.40195417
47MP0010155_abnormal_intestine_physiology1.39526839
48MP0004272_abnormal_basement_membrane1.39452676
49MP0002118_abnormal_lipid_homeostasis1.38634594
50MP0010094_abnormal_chromosome_stability1.37416550
51MP0006054_spinal_hemorrhage1.37109215
52MP0005319_abnormal_enzyme/_coenzyme1.36733182
53MP0005451_abnormal_body_composition1.35888361
54MP0008058_abnormal_DNA_repair1.35576677
55MP0008007_abnormal_cellular_replicative1.35367173
56MP0008004_abnormal_stomach_pH1.34903865
57MP0003186_abnormal_redox_activity1.33381861
58MP0010352_gastrointestinal_tract_polyps1.30338327
59MP0000566_synostosis1.27525276
60MP0004957_abnormal_blastocyst_morpholog1.25544484
61MP0001944_abnormal_pancreas_morphology1.23206924
62MP0004043_abnormal_pH_regulation1.23130351
63MP0003315_abnormal_perineum_morphology1.22880012
64MP0008260_abnormal_autophagy1.22126232
65MP0000537_abnormal_urethra_morphology1.20399128
66MP0002693_abnormal_pancreas_physiology1.18913225
67MP0004233_abnormal_muscle_weight1.17079327
68MP0001661_extended_life_span1.16893903
69MP0006036_abnormal_mitochondrial_physio1.15027583
70MP0000678_abnormal_parathyroid_gland1.14068030
71MP0002138_abnormal_hepatobiliary_system1.13145555
72MP0004782_abnormal_surfactant_physiolog1.10779796
73MP0003950_abnormal_plasma_membrane1.06456539
74MP0002938_white_spotting1.06177222
75MP0003718_maternal_effect1.05535541
76MP0006035_abnormal_mitochondrial_morpho1.04728206
77MP0003656_abnormal_erythrocyte_physiolo1.04441350
78MP0001727_abnormal_embryo_implantation1.03763415
79MP0001730_embryonic_growth_arrest1.03541096
80MP0001881_abnormal_mammary_gland1.02003613
81MP0003123_paternal_imprinting1.01792321
82MP0005501_abnormal_skin_physiology1.01747641
83MP0003566_abnormal_cell_adhesion0.99788537
84MP0005058_abnormal_lysosome_morphology0.98608221
85MP0005670_abnormal_white_adipose0.98238703
86MP0001756_abnormal_urination0.98061900
87MP0000013_abnormal_adipose_tissue0.94905589
88MP0000516_abnormal_urinary_system0.93420751
89MP0005367_renal/urinary_system_phenotyp0.93420751
90MP0002060_abnormal_skin_morphology0.93019463
91MP0000538_abnormal_urinary_bladder0.92989850
92MP0003195_calcinosis0.91902237
93MP0002078_abnormal_glucose_homeostasis0.91238784
94MP0010771_integument_phenotype0.90925791
95MP0000762_abnormal_tongue_morphology0.90837943
96MP0000598_abnormal_liver_morphology0.90817035
97MP0000647_abnormal_sebaceous_gland0.90497403
98MP0002877_abnormal_melanocyte_morpholog0.90224250
99MP0005377_hearing/vestibular/ear_phenot0.88492584
100MP0003878_abnormal_ear_physiology0.88492584
101MP0001765_abnormal_ion_homeostasis0.86127853
102MP0005165_increased_susceptibility_to0.85018641
103MP0002080_prenatal_lethality0.84756796
104MP0009780_abnormal_chondrocyte_physiolo0.84272801
105MP0002876_abnormal_thyroid_physiology0.83273033
106MP0004185_abnormal_adipocyte_glucose0.82031086
107MP0005410_abnormal_fertilization0.80566448
108MP0001216_abnormal_epidermal_layer0.79964325
109MP0009384_cardiac_valve_regurgitation0.78343821
110MP0000858_altered_metastatic_potential0.77319245
111MP0005266_abnormal_metabolism0.76737639
112MP0002896_abnormal_bone_mineralization0.75990213
113MP0004858_abnormal_nervous_system0.75156380
114MP0000003_abnormal_adipose_tissue0.73742896
115MP0005448_abnormal_energy_balance0.73649601
116MP0009642_abnormal_blood_homeostasis0.73629168
117MP0001243_abnormal_dermal_layer0.72710778
118MP0003453_abnormal_keratinocyte_physiol0.72522885
119MP0001849_ear_inflammation0.71977808
120MP0000470_abnormal_stomach_morphology0.71944529
121MP0004947_skin_inflammation0.71331081
122MP0000015_abnormal_ear_pigmentation0.71138879
123MP0000163_abnormal_cartilage_morphology0.70151153
124MP0010678_abnormal_skin_adnexa0.67864170
125MP0009379_abnormal_foot_pigmentation0.67609304
126MP0005023_abnormal_wound_healing0.67597833
127MP0005376_homeostasis/metabolism_phenot0.67350836
128MP0005395_other_phenotype0.67180753
129MP0005330_cardiomyopathy0.67120808
130MP0005197_abnormal_uvea_morphology0.66805087
131MP0005584_abnormal_enzyme/coenzyme_acti0.66523905
132MP0001697_abnormal_embryo_size0.66197067
133MP0002132_abnormal_respiratory_system0.66133766
134MP0003183_abnormal_peptide_metabolism0.65676021
135MP0009931_abnormal_skin_appearance0.64652339
136MP0005380_embryogenesis_phenotype0.64074783
137MP0001672_abnormal_embryogenesis/_devel0.64074783
138MP0000627_abnormal_mammary_gland0.63954366
139MP0003436_decreased_susceptibility_to0.63914501
140MP0009697_abnormal_copulation0.63845410
141MP0002136_abnormal_kidney_physiology0.63754272
142MP0002933_joint_inflammation0.63152185
143MP0000367_abnormal_coat/_hair0.62770310
144MP0000467_abnormal_esophagus_morphology0.61930749
145MP0004147_increased_porphyrin_level0.61504387
146MP0008469_abnormal_protein_level0.61441991

Predicted human phenotypes

RankGene SetZ-score
1Abnormal tarsal ossification (HP:0008369)5.14068441
2Irregular epiphyses (HP:0010582)4.38605406
3Hypoglycemic coma (HP:0001325)4.33166883
4Flat acetabular roof (HP:0003180)3.72150877
5Cupped ribs (HP:0000887)3.71806734
6Intrahepatic cholestasis (HP:0001406)3.71109705
7Abnormal foot bone ossification (HP:0010675)3.70738301
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.60904368
9Hypobetalipoproteinemia (HP:0003563)3.55265771
10Abnormality of glycolysis (HP:0004366)3.53867938
11Abnormality of monocarboxylic acid metabolism (HP:0010996)3.51992896
12Abnormal gallbladder physiology (HP:0012438)3.49924927
13Cholecystitis (HP:0001082)3.49924927
14Flat capital femoral epiphysis (HP:0003370)3.42058171
15Symptomatic seizures (HP:0011145)3.32620399
16Ileus (HP:0002595)3.29706867
17Abdominal distention (HP:0003270)3.26661693
18Hypoglycemic seizures (HP:0002173)3.21512561
19Increased serum pyruvate (HP:0003542)3.21163918
20Epiphyseal dysplasia (HP:0002656)3.19142838
21Delayed epiphyseal ossification (HP:0002663)3.10498060
22Xanthomatosis (HP:0000991)3.05715107
23Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93236976
24Abnormality of dicarboxylic acid metabolism (HP:0010995)2.92104727
25Dicarboxylic aciduria (HP:0003215)2.92104727
26Hepatocellular necrosis (HP:0001404)2.90112035
27Protuberant abdomen (HP:0001538)2.85875871
28Malnutrition (HP:0004395)2.83228726
29Abnormality of the intrinsic pathway (HP:0010989)2.82703438
30Flattened epiphyses (HP:0003071)2.82628159
31Late onset (HP:0003584)2.80629314
32Abnormality of carpal bone ossification (HP:0006257)2.78446267
33Right ventricular cardiomyopathy (HP:0011663)2.77509298
34Generalized aminoaciduria (HP:0002909)2.77253564
35Beaking of vertebral bodies (HP:0004568)2.74226944
36Abnormal mitochondria in muscle tissue (HP:0008316)2.74196604
37Hyperinsulinemic hypoglycemia (HP:0000825)2.72803152
38Hypokinesia (HP:0002375)2.70580318
39Fat malabsorption (HP:0002630)2.68961646
40Abnormal cartilage morphology (HP:0002763)2.66702212
41Genu varum (HP:0002970)2.64854051
42Hypolipoproteinemia (HP:0010981)2.61938135
43Abnormality of alanine metabolism (HP:0010916)2.60397274
44Hyperalaninemia (HP:0003348)2.60397274
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60397274
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.56182152
47Hyperammonemia (HP:0001987)2.55992387
48Small epiphyses (HP:0010585)2.54786571
49Rough bone trabeculation (HP:0100670)2.51853618
50Conjugated hyperbilirubinemia (HP:0002908)2.51562891
51Abnormality of fatty-acid metabolism (HP:0004359)2.50276877
52Abnormality of proline metabolism (HP:0010907)2.46927694
53Hydroxyprolinuria (HP:0003080)2.46927694
54Entropion (HP:0000621)2.46520782
55Glomerulosclerosis (HP:0000096)2.46244010
56Irregular vertebral endplates (HP:0003301)2.45838814
57Hyperglycinuria (HP:0003108)2.45801769
58Poikiloderma (HP:0001029)2.44850450
59Hepatic necrosis (HP:0002605)2.44197246
60Ketoacidosis (HP:0001993)2.42786037
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41933932
62Acute necrotizing encephalopathy (HP:0006965)2.41888545
63Upper limb muscle weakness (HP:0003484)2.41067259
64Reduced antithrombin III activity (HP:0001976)2.39030948
65Upper limb amyotrophy (HP:0009129)2.38235662
66Distal upper limb amyotrophy (HP:0007149)2.38235662
67Ketosis (HP:0001946)2.36054258
68Increased serum lactate (HP:0002151)2.35547297
69Vertebral clefting (HP:0008428)2.34519936
70Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34497235
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34497235
72Abnormal trabecular bone morphology (HP:0100671)2.28821727
73Microretrognathia (HP:0000308)2.28447377
74Increased CSF lactate (HP:0002490)2.27839902
75Mitochondrial inheritance (HP:0001427)2.26795331
76Focal segmental glomerulosclerosis (HP:0000097)2.26519964
77Metaphyseal irregularity (HP:0003025)2.26139120
78Abnormality of pyrimidine metabolism (HP:0004353)2.25675019
79Abnormal hair laboratory examination (HP:0003328)2.24735794
80Abnormality of the vertebral endplates (HP:0005106)2.23111430
81Lactic acidosis (HP:0003128)2.21925042
82Delayed CNS myelination (HP:0002188)2.21857846
83Deep venous thrombosis (HP:0002625)2.21140132
84Prolonged neonatal jaundice (HP:0006579)2.19769687
85Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.18781702
86Abnormality of femoral epiphyses (HP:0006499)2.18432554
87Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.18432554
88Vitreoretinal degeneration (HP:0000655)2.14888628
89Lethargy (HP:0001254)2.14671598
90Cerebral edema (HP:0002181)2.13747187
91Abnormality of the epiphysis of the femoral head (HP:0010574)2.13522340
92Nonimmune hydrops fetalis (HP:0001790)2.13141661
93Vertebral compression fractures (HP:0002953)2.12920390
94Abnormalities of placenta or umbilical cord (HP:0001194)2.12833378
95Abnormality of the proximal phalanges of the hand (HP:0009834)2.12301292
96Testicular atrophy (HP:0000029)2.11849239
97Abnormality of the common coagulation pathway (HP:0010990)2.11600921
98Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11279877
99Metaphyseal cupping (HP:0003021)2.11076064
100Vascular calcification (HP:0004934)2.09605264
101Hand muscle atrophy (HP:0009130)2.09324623
102Abnormal protein N-linked glycosylation (HP:0012347)2.08600945
103Abnormal protein glycosylation (HP:0012346)2.08600945
104Abnormal glycosylation (HP:0012345)2.08600945
105Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08600945
106Abnormality of sulfur amino acid metabolism (HP:0004339)2.08294545
107Abnormality of the umbilical cord (HP:0010881)2.07338842
108Spastic paraparesis (HP:0002313)2.06403403
109Abnormal hand bone ossification (HP:0010660)2.05958284
110Hyperbilirubinemia (HP:0002904)2.05525433
111Abnormal ossification of hand bones (HP:0005921)2.05085099
112Abnormality of glycine metabolism (HP:0010895)2.03484632
113Abnormality of serine family amino acid metabolism (HP:0010894)2.03484632
114Trismus (HP:0000211)2.01970959
115Type I transferrin isoform profile (HP:0003642)2.01868682
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99943683
117Short femoral neck (HP:0100864)1.98105095
118Proximal tubulopathy (HP:0000114)1.97926934
119Carpal bone hypoplasia (HP:0001498)1.97286478
120Prolonged partial thromboplastin time (HP:0003645)1.96010574
121Hypoalphalipoproteinemia (HP:0003233)1.95691562
122Abnormality of liposaccharide metabolism (HP:0010968)1.95598658
123Abnormality of glycosphingolipid metabolism (HP:0004343)1.95598658
124Abnormality of glycolipid metabolism (HP:0010969)1.95598658
125Hyperglycinemia (HP:0002154)1.95368198
126Hyperglycemia (HP:0003074)1.94459675
127Abnormality of the femoral head (HP:0003368)1.94336177
128Acute encephalopathy (HP:0006846)1.94231968
129Abnormality of the Achilles tendon (HP:0005109)1.93304678
130Ragged-red muscle fibers (HP:0003200)1.92370737
131Glycosuria (HP:0003076)1.91935834
132Abnormality of urine glucose concentration (HP:0011016)1.91935834
133Sparse eyelashes (HP:0000653)1.91911095
134Achilles tendon contracture (HP:0001771)1.91821754
135Abnormality of purine metabolism (HP:0004352)1.91017303
136Pili torti (HP:0003777)1.90566102
137Platyspondyly (HP:0000926)1.89952122
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.88686493
139Abnormal epiphyseal ossification (HP:0010656)1.88633249
140Hyperparathyroidism (HP:0000843)1.87758721
141Insulin resistance (HP:0000855)1.87631567
142Abnormal pancreas size (HP:0012094)1.86556290
143Exercise intolerance (HP:0003546)1.85098722
144Myopathic facies (HP:0002058)1.84342010
145Congenital ichthyosiform erythroderma (HP:0007431)1.83823890
146Paraparesis (HP:0002385)1.83753924
147Hemorrhage of the eye (HP:0011885)1.83683427
148Opisthotonus (HP:0002179)1.83573934
149Increased purine levels (HP:0004368)1.83461208
150Hyperuricemia (HP:0002149)1.83461208
151Spinal cord compression (HP:0002176)1.83022343
152Nausea (HP:0002018)1.82628412
153Palpitations (HP:0001962)1.80707180
154Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80705308
155CNS demyelination (HP:0007305)1.80467115
156Gout (HP:0001997)1.80337696
157Vacuolated lymphocytes (HP:0001922)1.80327192
158Distal lower limb amyotrophy (HP:0008944)1.79874030
159Abnormality of methionine metabolism (HP:0010901)1.78465558
160Abnormality of endocrine pancreas physiology (HP:0012093)1.77831267
161Abnormality of the pancreatic islet cells (HP:0006476)1.77831267
162Osteoarthritis (HP:0002758)1.77452350
163Abnormality of nucleobase metabolism (HP:0010932)1.76975361
164Squamous cell carcinoma (HP:0002860)1.76261991
165Reduced subcutaneous adipose tissue (HP:0003758)1.75126090
166Short nail (HP:0001799)1.74943648

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.07202676
2ERN13.92285672
3BCKDK3.34877018
4MAP2K23.06895663
5NME12.71823070
6EPHA22.69239054
7MST42.67675075
8TESK12.48253490
9PIK3CA2.47720769
10NME22.44696505
11VRK22.31370856
12TRIB32.14515598
13PDK22.14432073
14PKN22.00003352
15MAP3K31.97174752
16STK38L1.94830774
17PRKG21.91992735
18TESK21.89130881
19MET1.84484008
20BUB11.80953726
21FRK1.78542922
22MAP3K121.77005975
23PASK1.75487044
24MAP3K111.68989074
25TAOK31.64859469
26MAP3K21.62264703
27PIM21.61450106
28BRSK21.61378663
29PTK61.54335730
30FLT31.53385323
31DDR21.52188455
32BRAF1.44084902
33SIK11.42131245
34PIK3CG1.41188846
35MAP2K11.39755033
36SMG11.38286739
37EIF2AK31.35191190
38LMTK21.32151193
39CCNB11.31468566
40KDR1.25953108
41NUAK11.24697728
42INSRR1.24093035
43RPS6KB21.22680337
44MAPKAPK31.20972259
45LIMK11.18653472
46KSR21.18552224
47ARAF1.15582420
48PTK21.13735389
49MAP3K81.12688455
50PRKCI1.05189457
51SRPK11.03074052
52EIF2AK11.02785727
53TSSK60.98496979
54ZAP700.96867217
55TAOK10.93098251
56EPHB20.88986161
57SCYL20.87727914
58DAPK10.87406672
59TAOK20.86745373
60CSNK1G30.84784095
61LRRK20.83130982
62MAP3K10.81711112
63MYLK0.80730478
64EPHA30.78924055
65NEK10.78046885
66GRK60.77002875
67WNK40.74228410
68STK160.72756318
69MAP3K100.72546436
70ERBB40.71396118
71CSNK1A1L0.69744196
72MAPK110.69085259
73FER0.68513178
74TLK10.68283662
75PBK0.68083739
76TRIM280.67774301
77PAK40.67214870
78CDK70.65252554
79SIK30.64332937
80CAMKK20.64027591
81BRSK10.63639307
82ICK0.63619685
83AURKB0.62762514
84CDC70.60813083
85TTK0.60760548
86PAK10.60245569
87STK100.59514646
88EEF2K0.57614374
89PLK40.56149368
90MAP2K60.55042662
91FGFR40.54118074
92AKT20.50066396
93RAF10.49214593
94MATK0.48096437
95VRK10.48058739
96BCR0.47465858
97BMX0.47111550
98RIPK10.45556321
99MAP2K70.45387765
100ILK0.44595090
101ABL20.44505006
102EPHB10.44439885
103CAMK2G0.43356933
104CHEK20.43217340
105WEE10.42377182
106NEK20.42321393
107ERBB20.42019476
108LATS10.41896293
109ZAK0.41676438
110MAPK150.41653422
111TBK10.40227100
112CDK80.40133613
113CSNK1G10.39287059
114MAP2K30.39154771
115NTRK10.38620686
116CDC42BPA0.38401726
117CDK90.38361625
118DAPK30.38024345
119ATR0.37030898
120CSNK1G20.36955685
121PDPK10.35831278
122TYK20.34541148
123PDGFRA0.34493169
124RPS6KA40.34421642
125IRAK30.33924302
126GRK10.33203842
127CSNK2A10.32289390
128TEC0.31427560
129CSNK2A20.29794306
130CAMK2D0.29786431
131AURKA0.29432357
132PRKD30.29209167
133MAP3K70.28698248
134CSNK1A10.27500679
135BLK0.27388938
136ACVR1B0.26822680
137CDK180.25682144
138PLK10.25501753
139CDK11A0.24430731
140CDK140.23355770
141DYRK1B0.22954696
142CDK150.21497187

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.51165425
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.37979665
3Fat digestion and absorption_Homo sapiens_hsa049752.82662387
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.59639457
5Folate biosynthesis_Homo sapiens_hsa007902.47327992
6Protein export_Homo sapiens_hsa030602.26545013
7* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.22687358
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19081431
9Fatty acid degradation_Homo sapiens_hsa000712.10549523
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.01440467
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00500726
12Pyruvate metabolism_Homo sapiens_hsa006201.94514046
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94384575
14Fructose and mannose metabolism_Homo sapiens_hsa000511.92175790
15Tryptophan metabolism_Homo sapiens_hsa003801.86768735
16Base excision repair_Homo sapiens_hsa034101.86137998
17Sulfur relay system_Homo sapiens_hsa041221.74506266
18Selenocompound metabolism_Homo sapiens_hsa004501.73996733
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.71476061
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66432531
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.65399402
22Carbon metabolism_Homo sapiens_hsa012001.59597790
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.58979646
24Histidine metabolism_Homo sapiens_hsa003401.54161616
25Propanoate metabolism_Homo sapiens_hsa006401.48518102
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46994112
27Proteasome_Homo sapiens_hsa030501.38151992
28* Galactose metabolism_Homo sapiens_hsa000521.36752307
29Oxidative phosphorylation_Homo sapiens_hsa001901.34507737
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34376464
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32992885
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32315794
33Arginine biosynthesis_Homo sapiens_hsa002201.31759237
34Butanoate metabolism_Homo sapiens_hsa006501.31538904
35Starch and sucrose metabolism_Homo sapiens_hsa005001.31171944
36Steroid biosynthesis_Homo sapiens_hsa001001.31044680
37Fatty acid metabolism_Homo sapiens_hsa012121.30522287
38Peroxisome_Homo sapiens_hsa041461.30063092
39Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29942324
40Glutathione metabolism_Homo sapiens_hsa004801.28872371
41Ribosome_Homo sapiens_hsa030101.26827290
42Pentose phosphate pathway_Homo sapiens_hsa000301.26005495
43PPAR signaling pathway_Homo sapiens_hsa033201.22685534
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22614465
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.21317317
46Chemical carcinogenesis_Homo sapiens_hsa052041.18336945
47Arginine and proline metabolism_Homo sapiens_hsa003301.18003194
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.16862625
49Nucleotide excision repair_Homo sapiens_hsa034201.16581021
50Caffeine metabolism_Homo sapiens_hsa002321.14316204
51Biosynthesis of amino acids_Homo sapiens_hsa012301.12134333
52N-Glycan biosynthesis_Homo sapiens_hsa005101.09127870
53Mineral absorption_Homo sapiens_hsa049781.07657474
54Parkinsons disease_Homo sapiens_hsa050121.07357165
55Bile secretion_Homo sapiens_hsa049761.06972768
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06402139
57Nitrogen metabolism_Homo sapiens_hsa009101.04992053
58RNA polymerase_Homo sapiens_hsa030201.04509615
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01143481
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00886550
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00857738
62Protein digestion and absorption_Homo sapiens_hsa049740.99621937
63Glycerolipid metabolism_Homo sapiens_hsa005610.99515336
64alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99371389
65One carbon pool by folate_Homo sapiens_hsa006700.99237830
66Homologous recombination_Homo sapiens_hsa034400.95763368
67beta-Alanine metabolism_Homo sapiens_hsa004100.94876234
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.94822548
69Phenylalanine metabolism_Homo sapiens_hsa003600.94733903
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.93382399
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90181702
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.89869451
73Vitamin digestion and absorption_Homo sapiens_hsa049770.89405671
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88347597
75Linoleic acid metabolism_Homo sapiens_hsa005910.87503296
76Bladder cancer_Homo sapiens_hsa052190.85681439
77Tyrosine metabolism_Homo sapiens_hsa003500.85036631
78Vitamin B6 metabolism_Homo sapiens_hsa007500.83481323
79* Metabolic pathways_Homo sapiens_hsa011000.82200803
80Retinol metabolism_Homo sapiens_hsa008300.75680500
81Fatty acid elongation_Homo sapiens_hsa000620.74551132
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73034561
83Renin-angiotensin system_Homo sapiens_hsa046140.72630516
84Pyrimidine metabolism_Homo sapiens_hsa002400.71888242
85Fanconi anemia pathway_Homo sapiens_hsa034600.71077997
86ABC transporters_Homo sapiens_hsa020100.70471506
87Alzheimers disease_Homo sapiens_hsa050100.69989130
88Complement and coagulation cascades_Homo sapiens_hsa046100.68926826
89Pancreatic secretion_Homo sapiens_hsa049720.68088715
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.67566800
91Spliceosome_Homo sapiens_hsa030400.66569599
92RNA transport_Homo sapiens_hsa030130.65515317
93Lysosome_Homo sapiens_hsa041420.64252769
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63015087
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62831050
96Other glycan degradation_Homo sapiens_hsa005110.61510549
97Vibrio cholerae infection_Homo sapiens_hsa051100.58644459
98Purine metabolism_Homo sapiens_hsa002300.58296369
99Collecting duct acid secretion_Homo sapiens_hsa049660.56250612
100Huntingtons disease_Homo sapiens_hsa050160.53916686
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53005100
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52007246
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51675565
104Arachidonic acid metabolism_Homo sapiens_hsa005900.50562715
105Thyroid cancer_Homo sapiens_hsa052160.50155723
106Fatty acid biosynthesis_Homo sapiens_hsa000610.48169645
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47534806
108Non-homologous end-joining_Homo sapiens_hsa034500.38461485
109DNA replication_Homo sapiens_hsa030300.38364978
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.36743366
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35942204
112Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34382331
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29727338
114Mismatch repair_Homo sapiens_hsa034300.28692168
115Sphingolipid metabolism_Homo sapiens_hsa006000.27960490
116Thyroid hormone synthesis_Homo sapiens_hsa049180.22124280
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22122532
118Legionellosis_Homo sapiens_hsa051340.21532942
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21287962

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