GAL3ST4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate to the C-3' position of galactose residues in O-linked glycoproteins. This enzyme is highly specific for core 1 structures, with asialofetuin, Gal-beta-1,3-GalNAc and Gal-beta-1,3 (GlcNAc-beta-1,6)GalNAc being good substrates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)9.40245537
2G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)8.41264053
3regulation of chemokine secretion (GO:0090196)8.24982924
4regulation of interferon-beta biosynthetic process (GO:0045357)6.55571750
5pyrimidine nucleobase catabolic process (GO:0006208)6.38520747
6macrophage activation involved in immune response (GO:0002281)6.15804456
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.79073739
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.79073739
9modulation by symbiont of host immune response (GO:0052553)5.79073739
10positive regulation by symbiont of host defense response (GO:0052509)5.79073739
11modulation by symbiont of host defense response (GO:0052031)5.79073739
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.79073739
13chondroitin sulfate catabolic process (GO:0030207)5.67846778
14behavioral response to nicotine (GO:0035095)5.54758893
15purinergic nucleotide receptor signaling pathway (GO:0035590)5.49214268
16regulation of antigen processing and presentation of peptide antigen (GO:0002583)5.41949484
17G-protein coupled purinergic receptor signaling pathway (GO:0035588)5.27868417
18oligosaccharide catabolic process (GO:0009313)5.16580963
19ceramide catabolic process (GO:0046514)4.97018540
20macrophage activation (GO:0042116)4.95166570
21keratan sulfate catabolic process (GO:0042340)4.86296611
22nucleobase catabolic process (GO:0046113)4.84477333
23negative regulation of granulocyte differentiation (GO:0030853)4.76803204
24glycosphingolipid catabolic process (GO:0046479)4.76664689
25axonal fasciculation (GO:0007413)4.59198503
26neuron recognition (GO:0008038)4.49081864
27negative regulation of tissue remodeling (GO:0034104)4.41055097
28forebrain neuron differentiation (GO:0021879)4.34586708
29establishment of mitochondrion localization (GO:0051654)4.30234838
30presynaptic membrane organization (GO:0097090)4.29678289
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29405043
32cyclooxygenase pathway (GO:0019371)4.20952280
33glycolipid catabolic process (GO:0019377)4.18542131
34purinergic receptor signaling pathway (GO:0035587)4.15185367
35postsynaptic membrane organization (GO:0001941)4.11798108
36regulation of cilium movement (GO:0003352)4.05345349
37negative regulation of norepinephrine secretion (GO:0010700)4.02927958
38negative regulation of axon guidance (GO:1902668)3.95779146
39adenosine receptor signaling pathway (GO:0001973)3.92066323
40negative regulation of axon extension involved in axon guidance (GO:0048843)3.89951993
41neuronal ion channel clustering (GO:0045161)3.89049050
42positive regulation of antigen processing and presentation (GO:0002579)3.88041062
43dendritic spine morphogenesis (GO:0060997)3.84375464
44regulation of extracellular matrix disassembly (GO:0010715)3.83133115
45retinal ganglion cell axon guidance (GO:0031290)3.80141090
46negative regulation of multicellular organism growth (GO:0040015)3.79324317
47head development (GO:0060322)3.79314792
48response to host defenses (GO:0052200)3.78839984
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.78839984
50response to host (GO:0075136)3.78839984
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75857065
52transmission of nerve impulse (GO:0019226)3.75105438
53axon extension (GO:0048675)3.73728523
54monocyte differentiation (GO:0030224)3.72602172
55spinal cord development (GO:0021510)3.71162167
56outer ear morphogenesis (GO:0042473)3.70538068
57negative regulation of glycoprotein metabolic process (GO:1903019)3.70029357
58desmosome organization (GO:0002934)3.69182078
59positive regulation of cellular amide metabolic process (GO:0034250)3.66670920
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.65703625
61hyaluronan catabolic process (GO:0030214)3.65626104
62regulation of microtubule-based movement (GO:0060632)3.64444446
63cell proliferation in forebrain (GO:0021846)3.64005382
64pathway-restricted SMAD protein phosphorylation (GO:0060389)3.63335144
65positive regulation of gastrulation (GO:2000543)3.59922965
66response to cholesterol (GO:0070723)3.59558772
67negative regulation of systemic arterial blood pressure (GO:0003085)3.59132829
68cell migration in hindbrain (GO:0021535)3.58158043
69presynaptic membrane assembly (GO:0097105)3.57677695
70protein polyglutamylation (GO:0018095)3.52476615
71phagocytosis, engulfment (GO:0006911)3.50138517
72substrate-independent telencephalic tangential migration (GO:0021826)3.49549165
73substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.49549165
74negative regulation of stress fiber assembly (GO:0051497)3.49513204
75synapse assembly (GO:0007416)3.48418804
76olfactory bulb development (GO:0021772)3.48381875
77synaptic transmission, cholinergic (GO:0007271)3.47527054
78response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.47328556
79response to host immune response (GO:0052572)3.47328556
80mitochondrion transport along microtubule (GO:0047497)3.47218157
81establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.47218157
82macrophage differentiation (GO:0030225)3.46852447
83axon extension involved in axon guidance (GO:0048846)3.44534623
84neuron projection extension involved in neuron projection guidance (GO:1902284)3.44534623
85positive regulation of interferon-alpha production (GO:0032727)3.44208158
86regulation of synapse structural plasticity (GO:0051823)3.43852007
87adaptation of signaling pathway (GO:0023058)3.36775345
88positive regulation of B cell differentiation (GO:0045579)3.35454577
89I-kappaB phosphorylation (GO:0007252)3.34501084
90nonmotile primary cilium assembly (GO:0035058)3.32827986
91neuron cell-cell adhesion (GO:0007158)3.30719286
92regulation of B cell receptor signaling pathway (GO:0050855)3.29296081
93sphingolipid catabolic process (GO:0030149)3.29265107
94ruffle organization (GO:0031529)3.28849240
95tachykinin receptor signaling pathway (GO:0007217)3.28832363
96regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.28168459
97extracellular fibril organization (GO:0043206)3.27283062
98daunorubicin metabolic process (GO:0044597)3.24049833
99polyketide metabolic process (GO:0030638)3.24049833
100doxorubicin metabolic process (GO:0044598)3.24049833
101regulation of interferon-alpha production (GO:0032647)3.23040387
102spinal cord association neuron differentiation (GO:0021527)3.20524060
103regulation of cell proliferation involved in kidney development (GO:1901722)3.19640036
104protein localization to synapse (GO:0035418)3.19251756
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.15718812
106positive regulation of chemokine production (GO:0032722)3.15194881
107ganglion development (GO:0061548)3.12593268
108negative regulation of transcription regulatory region DNA binding (GO:2000678)3.12569365
109cerebral cortex radially oriented cell migration (GO:0021799)3.10672840
110positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.09624272
111negative regulation of axon extension (GO:0030517)3.08439035
112response to sterol (GO:0036314)3.08106027
113ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.07747561
114regulation of axon guidance (GO:1902667)3.07726696
115ganglioside metabolic process (GO:0001573)3.05605835
116brain morphogenesis (GO:0048854)3.03293952
117neurotransmitter-gated ion channel clustering (GO:0072578)3.03064383
118parturition (GO:0007567)3.02213077
119central nervous system projection neuron axonogenesis (GO:0021952)3.02001768
120response to muramyl dipeptide (GO:0032495)3.01760148
121regulation of antigen processing and presentation (GO:0002577)3.01519675
122myeloid cell activation involved in immune response (GO:0002275)3.00426339
123regulation of collateral sprouting (GO:0048670)2.98419366
124auditory behavior (GO:0031223)2.97943364
125lysosome organization (GO:0007040)2.97015197
126lytic vacuole organization (GO:0080171)2.97015197
127negative regulation of bone resorption (GO:0045779)2.96924451
128hippocampus development (GO:0021766)2.96638453
129sodium-independent organic anion transport (GO:0043252)2.95382734
130macrophage chemotaxis (GO:0048246)2.94784718
131central nervous system myelination (GO:0022010)2.94600446
132axon ensheathment in central nervous system (GO:0032291)2.94600446
133adult walking behavior (GO:0007628)2.94586472
134neuron projection extension (GO:1990138)2.94347446
135negative regulation of interleukin-6 production (GO:0032715)2.94044304
136negative regulation of axonogenesis (GO:0050771)2.92780187
137regulation of axon extension involved in axon guidance (GO:0048841)2.92490077
138positive regulation of synapse assembly (GO:0051965)2.92354674
139dendrite morphogenesis (GO:0048813)2.91537906
140membrane lipid catabolic process (GO:0046466)2.91098609
141gland morphogenesis (GO:0022612)2.88246788
142nucleoside diphosphate catabolic process (GO:0009134)2.86809343
143negative regulation of mast cell activation (GO:0033004)2.86780894
144cellular extravasation (GO:0045123)2.86013310
145short-term memory (GO:0007614)2.84795544
146response to peptidoglycan (GO:0032494)2.84567851
147cellular response to interferon-beta (GO:0035458)2.84418637
148limb bud formation (GO:0060174)2.84375314
149negative regulation of response to food (GO:0032096)2.82609315
150negative regulation of appetite (GO:0032099)2.82609315
151germ cell migration (GO:0008354)2.82305789
152regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82140034
153pharyngeal system development (GO:0060037)2.81730042
154microtubule severing (GO:0051013)2.81544638
155gamma-aminobutyric acid transport (GO:0015812)2.80647491
156positive regulation of NF-kappaB import into nucleus (GO:0042346)2.79635737
157neurofilament cytoskeleton organization (GO:0060052)2.79065642
158regulation of monocyte differentiation (GO:0045655)2.78794409
159epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78357760
160cerebellar Purkinje cell differentiation (GO:0021702)2.77059580
161cell-cell junction maintenance (GO:0045217)2.76944994
162regulation of mast cell activation involved in immune response (GO:0033006)2.75299858
163positive regulation of mitochondrial fission (GO:0090141)2.74031744
164negative regulation of bone remodeling (GO:0046851)2.73902272
165fibril organization (GO:0097435)2.72458000
166negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.70545369
167Rac protein signal transduction (GO:0016601)2.68645563
168L-serine transport (GO:0015825)2.67071594
169negative regulation of osteoclast differentiation (GO:0045671)2.65613782
170cell junction maintenance (GO:0034331)2.64815727
171regulation of extent of cell growth (GO:0061387)2.64421140
172cornea development in camera-type eye (GO:0061303)2.63419565
173epithelial cilium movement (GO:0003351)2.61999337
174negative regulation of smooth muscle contraction (GO:0045986)2.61638432
175regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.61341739
176protein insertion into membrane (GO:0051205)2.60830947
177mechanosensory behavior (GO:0007638)2.59014005
178synaptic vesicle maturation (GO:0016188)2.58791600
179protein localization to cilium (GO:0061512)2.58715653
180regulation of axon extension (GO:0030516)2.58438220
181vocalization behavior (GO:0071625)2.58193082
182respiratory burst (GO:0045730)2.57977245
183regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.57518659
184negative regulation of actin filament bundle assembly (GO:0032232)2.56869112
185neural tube formation (GO:0001841)2.56621634
186negative regulation of synaptic transmission, GABAergic (GO:0032229)2.56304941
187nervous system development (GO:0007399)2.56105684
188regulation of interleukin-6 biosynthetic process (GO:0045408)2.55650638
189negative regulation of interleukin-2 production (GO:0032703)2.55536917
190regulation of feeding behavior (GO:0060259)2.52937563
191response to auditory stimulus (GO:0010996)2.51296561
192regulation of membrane repolarization (GO:0060306)2.51166040
193G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51157269
194synapse organization (GO:0050808)2.51083734
195neuron migration (GO:0001764)2.50577957
196somite development (GO:0061053)2.49412170
197positive regulation of potassium ion transmembrane transport (GO:1901381)2.45577967
198positive regulation of chemokine secretion (GO:0090197)10.6169291

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.79612991
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.03500372
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.23628184
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.00139556
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.96913357
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.62845340
7SCL_19346495_ChIP-Seq_HPC-7_Human3.38996186
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.31208953
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.29279870
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.02017787
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.89232051
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.75662209
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.69062007
14REST_21632747_ChIP-Seq_MESCs_Mouse2.61883706
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.58964319
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.57893250
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53822694
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.51785240
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.48922427
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35134599
21GATA1_22025678_ChIP-Seq_K562_Human2.34337355
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30675563
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28075377
24ZNF274_21170338_ChIP-Seq_K562_Hela2.27582445
25RUNX_20019798_ChIP-Seq_JUKART_Human2.26909370
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25900459
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22682802
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20827292
29REST_18959480_ChIP-ChIP_MESCs_Mouse2.17045276
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.15550868
31EZH2_27294783_Chip-Seq_ESCs_Mouse2.15049233
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11859439
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.02565994
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.02374241
35SPI1_23127762_ChIP-Seq_K562_Human1.99561584
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98841459
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98841459
38VDR_21846776_ChIP-Seq_THP-1_Human1.97919670
39VDR_24787735_ChIP-Seq_THP-1_Human1.96292276
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93807514
41VDR_24763502_ChIP-Seq_THP-1_Human1.92401892
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.91472743
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85433262
44SPI1_23547873_ChIP-Seq_NB4_Human1.83687042
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83283712
46SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82555902
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81638897
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.76605867
49NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.76217562
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73723276
51RNF2_27304074_Chip-Seq_NSC_Mouse1.70758184
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69176816
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68450547
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65903434
55FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65717490
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64470915
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.61981612
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.59630475
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.57861967
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.56034224
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54795201
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.54181153
63GBX2_23144817_ChIP-Seq_PC3_Human1.53969736
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48082276
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.47564469
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46983213
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46983213
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44949176
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44684853
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.43639745
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41482339
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39701266
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.38389564
74PU_27001747_Chip-Seq_BMDM_Mouse1.37142004
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36773353
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36725883
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36417955
78VDR_22108803_ChIP-Seq_LS180_Human1.35788324
79SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35244406
80IGF1R_20145208_ChIP-Seq_DFB_Human1.34923032
81RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.32574024
82MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31148365
83* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26887094
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.26548597
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24154680
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.24035680
87PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23708189
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23389161
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22929259
90CJUN_26792858_Chip-Seq_BT549_Human1.22064939
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21949833
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20118968
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19915587
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17625407
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17115550
96CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.14825362
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11466897
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.11047913
99SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11047857
100TP53_18474530_ChIP-ChIP_U2OS_Human1.07485969
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06873637
102TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.06836763
103* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06503287
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.06402993
105SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06233909
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05713654
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05587326
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.05318788
109AR_21572438_ChIP-Seq_LNCaP_Human1.04815910
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04631548
111POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04151808
112IRF1_19129219_ChIP-ChIP_H3396_Human1.03594991
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03239936
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.02967967
115TCF7_22412390_ChIP-Seq_EML_Mouse1.02232383
116MYB_26560356_Chip-Seq_TH2_Human1.02077617
117SMAD3_21741376_ChIP-Seq_ESCs_Human1.01268310
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.01150922
119TAF15_26573619_Chip-Seq_HEK293_Human0.99442793
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99325039
121SMAD3_21741376_ChIP-Seq_HESCs_Human0.98730259
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98358425
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96558786
124CTCF_27219007_Chip-Seq_Bcells_Human0.96489372
125KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96268771
126CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95812478
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95455202
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94990606
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94829031
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.94555822
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94332075
132STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94173320
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93939793
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92742695
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92474791
136CBP_20019798_ChIP-Seq_JUKART_Human0.92474791
137GATA3_26560356_Chip-Seq_TH2_Human0.92419041
138GATA2_19941826_ChIP-Seq_K562_Human0.91889886
139NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91637133
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91557508
141KDM2B_26808549_Chip-Seq_K562_Human0.91024847
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.90861951
143DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90517621
144TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90443383
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.90392770
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90123031
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89280563
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88757466
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.88632649
150OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88532242
151SMAD4_21799915_ChIP-Seq_A2780_Human0.88508401
152TP63_23658742_ChIP-Seq_EP156T_Human0.88472207
153AR_25329375_ChIP-Seq_VCAP_Human0.88098471
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87145802
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.85629367
156PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85427780
157SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.84420911
158EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84292855
159GATA3_27048872_Chip-Seq_THYMUS_Human0.84175178
160BCAT_22108803_ChIP-Seq_LS180_Human0.83767642
161EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83657790
162TAL1_26923725_Chip-Seq_HPCs_Mouse0.83469365
163GATA1_26923725_Chip-Seq_HPCs_Mouse0.83359343
164ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.83307224
165RUNX2_22187159_ChIP-Seq_PCA_Human0.83289075
166RARB_27405468_Chip-Seq_BRAIN_Mouse0.83258314
167MYC_22102868_ChIP-Seq_BL_Human0.81599230
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81520752
169ARNT_22903824_ChIP-Seq_MCF-7_Human0.81266098
170GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81138276
171GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80757401
172SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80299468
173GATA1_19941827_ChIP-Seq_MEL_Mouse0.77919390
174SOX2_20726797_ChIP-Seq_SW620_Human0.77911546
175DROSHA_22980978_ChIP-Seq_HELA_Human0.75391597
176KDM2B_26808549_Chip-Seq_SUP-B15_Human0.75074846
177TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74820153
178SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74473868
179CDX2_20551321_ChIP-Seq_CACO-2_Human0.74236088
180NFIB_24661679_ChIP-Seq_LUNG_Mouse0.72500090
181LXR_22292898_ChIP-Seq_THP-1_Human0.71963497
182TCF4_22108803_ChIP-Seq_LS180_Human0.71622934
183P300_19829295_ChIP-Seq_ESCs_Human0.71449649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.91206696
2MP0005058_abnormal_lysosome_morphology3.80385463
3MP0006082_CNS_inflammation3.63813422
4MP0005423_abnormal_somatic_nervous3.53772752
5MP0003787_abnormal_imprinting3.42103551
6MP0002254_reproductive_system_inflammat3.28924614
7MP0000778_abnormal_nervous_system3.20270098
8MP0003172_abnormal_lysosome_physiology3.14327273
9MP0003183_abnormal_peptide_metabolism3.06273578
10MP0003122_maternal_imprinting2.93572253
11MP0003880_abnormal_central_pattern2.90778432
12MP0009384_cardiac_valve_regurgitation2.88997635
13MP0003075_altered_response_to2.88319586
14MP0005671_abnormal_response_to2.84559747
15MP0008004_abnormal_stomach_pH2.71137744
16MP0002653_abnormal_ependyma_morphology2.66146548
17MP0005464_abnormal_platelet_physiology2.64644874
18MP0001984_abnormal_olfaction2.51819851
19MP0005275_abnormal_skin_tensile2.48439292
20MP0006276_abnormal_autonomic_nervous2.44646720
21MP0003121_genomic_imprinting2.39955063
22MP0001835_abnormal_antigen_presentation2.36326011
23MP0003690_abnormal_glial_cell2.35678101
24MP0005394_taste/olfaction_phenotype2.35578249
25MP0005499_abnormal_olfactory_system2.35578249
26MP0008789_abnormal_olfactory_epithelium2.28514948
27MP0008007_abnormal_cellular_replicative2.25779942
28MP0002419_abnormal_innate_immunity2.24621318
29MP0003279_aneurysm2.24205898
30MP0000465_gastrointestinal_hemorrhage2.22730344
31MP0000566_synostosis2.15516904
32MP0004859_abnormal_synaptic_plasticity2.02084874
33MP0003123_paternal_imprinting1.99855353
34MP0002396_abnormal_hematopoietic_system1.96652200
35MP0003635_abnormal_synaptic_transmissio1.95084853
36MP0004133_heterotaxia1.93080920
37MP0002102_abnormal_ear_morphology1.92693832
38MP0001851_eye_inflammation1.84270161
39MP0002184_abnormal_innervation1.83996959
40MP0003941_abnormal_skin_development1.82404531
41MP0000955_abnormal_spinal_cord1.81855785
42MP0005551_abnormal_eye_electrophysiolog1.80505952
43MP0002063_abnormal_learning/memory/cond1.79466137
44MP0003566_abnormal_cell_adhesion1.78579348
45MP0005166_decreased_susceptibility_to1.78193130
46MP0002557_abnormal_social/conspecific_i1.77580960
47MP0000383_abnormal_hair_follicle1.71454434
48MP0002452_abnormal_antigen_presenting1.71078693
49MP0001533_abnormal_skeleton_physiology1.69724921
50MP0002272_abnormal_nervous_system1.69670240
51MP0002148_abnormal_hypersensitivity_rea1.67865817
52MP0001970_abnormal_pain_threshold1.65862748
53MP0008438_abnormal_cutaneous_collagen1.64597264
54MP0002882_abnormal_neuron_morphology1.61433960
55MP0002166_altered_tumor_susceptibility1.60000721
56MP0002572_abnormal_emotion/affect_behav1.58756477
57MP0002009_preneoplasia1.58598425
58MP0009745_abnormal_behavioral_response1.58538639
59MP0002822_catalepsy1.55921447
60MP0001188_hyperpigmentation1.54184564
61MP0003890_abnormal_embryonic-extraembry1.53704355
62MP0002796_impaired_skin_barrier1.53600034
63MP0002752_abnormal_somatic_nervous1.53076752
64MP0004142_abnormal_muscle_tone1.52988856
65MP0005171_absent_coat_pigmentation1.51035029
66MP0002734_abnormal_mechanical_nocicepti1.50350913
67MP0004270_analgesia1.49962499
68MP0002090_abnormal_vision1.48796067
69MP0002064_seizures1.48776065
70MP0004885_abnormal_endolymph1.47820973
71MP0004883_abnormal_blood_vessel1.47121300
72MP0003436_decreased_susceptibility_to1.46990034
73MP0002060_abnormal_skin_morphology1.46457986
74MP0002733_abnormal_thermal_nociception1.45719447
75MP0003646_muscle_fatigue1.45651790
76MP0010386_abnormal_urinary_bladder1.45410135
77MP0002837_dystrophic_cardiac_calcinosis1.45253563
78MP0002998_abnormal_bone_remodeling1.44514766
79MP0001819_abnormal_immune_cell1.41815735
80MP0001485_abnormal_pinna_reflex1.41675052
81MP0001542_abnormal_bone_strength1.40591269
82MP0005645_abnormal_hypothalamus_physiol1.40319048
83MP0004811_abnormal_neuron_physiology1.39673553
84MP0002420_abnormal_adaptive_immunity1.39180605
85MP0003011_delayed_dark_adaptation1.38644021
86MP0001529_abnormal_vocalization1.35179494
87MP0002723_abnormal_immune_serum1.33870767
88MP0005000_abnormal_immune_tolerance1.31315108
89MP0001800_abnormal_humoral_immune1.31094515
90MP0002638_abnormal_pupillary_reflex1.30689619
91MP0000026_abnormal_inner_ear1.30563312
92MP0004742_abnormal_vestibular_system1.29264393
93MP0001486_abnormal_startle_reflex1.28868659
94MP0005390_skeleton_phenotype1.28459926
95MP0001968_abnormal_touch/_nociception1.27540775
96MP0001440_abnormal_grooming_behavior1.27435669
97MP0003136_yellow_coat_color1.24436936
98MP0005195_abnormal_posterior_eye1.23762375
99MP0000631_abnormal_neuroendocrine_gland1.23514452
100MP0009046_muscle_twitch1.23440527
101MP0010678_abnormal_skin_adnexa1.23022554
102MP0002152_abnormal_brain_morphology1.22435747
103MP0002933_joint_inflammation1.21196640
104MP0003303_peritoneal_inflammation1.21158681
105MP0002067_abnormal_sensory_capabilities1.19496169
106MP0001853_heart_inflammation1.19487414
107MP0005508_abnormal_skeleton_morphology1.19404945
108MP0004145_abnormal_muscle_electrophysio1.18173726
109MP0002751_abnormal_autonomic_nervous1.15533488
110MP0005023_abnormal_wound_healing1.14745963
111MP0003938_abnormal_ear_development1.12795599
112MP0002735_abnormal_chemical_nociception1.12725124
113MP0005646_abnormal_pituitary_gland1.11935870
114MP0008877_abnormal_DNA_methylation1.11917260
115MP0001915_intracranial_hemorrhage1.11735277
116MP0000343_altered_response_to1.10532225
117MP0001216_abnormal_epidermal_layer1.09415259
118MP0003300_gastrointestinal_ulcer1.05262754
119MP0008995_early_reproductive_senescence1.04880067
120MP0002928_abnormal_bile_duct1.04687704
121MP0003724_increased_susceptibility_to1.03924807
122MP0005253_abnormal_eye_physiology1.03552025
123MP0001905_abnormal_dopamine_level1.03550906
124MP0006292_abnormal_olfactory_placode1.01901278
125MP0000858_altered_metastatic_potential1.01534352
126MP0002229_neurodegeneration1.00387624
127MP0003861_abnormal_nervous_system1.00219079
128MP0003329_amyloid_beta_deposits0.98913085
129MP0005025_abnormal_response_to0.98706226
130MP0000716_abnormal_immune_system0.97381363
131MP0002163_abnormal_gland_morphology0.95587784
132MP0005670_abnormal_white_adipose0.95300174
133MP0003633_abnormal_nervous_system0.95268924
134MP0003453_abnormal_keratinocyte_physiol0.94491509
135MP0003045_fibrosis0.91437760
136MP0002398_abnormal_bone_marrow0.90993106
137MP0000049_abnormal_middle_ear0.90872663
138MP0001963_abnormal_hearing_physiology0.90701223
139MP0001324_abnormal_eye_pigmentation0.90654385
140MP0005084_abnormal_gallbladder_morpholo0.90132522
141MP0003879_abnormal_hair_cell0.89324918
142MP0008469_abnormal_protein_level0.87648665
143MP0002095_abnormal_skin_pigmentation0.87596080
144MP0000604_amyloidosis0.87420456
145MP0002066_abnormal_motor_capabilities/c0.87323059
146MP0000538_abnormal_urinary_bladder0.87281716
147MP0003942_abnormal_urinary_system0.87133099
148MP0010771_integument_phenotype0.87045849
149MP0006072_abnormal_retinal_apoptosis0.86896237
150MP0001845_abnormal_inflammatory_respons0.86569642
151MP0001346_abnormal_lacrimal_gland0.86400224
152MP0000689_abnormal_spleen_morphology0.85559384
153MP0002098_abnormal_vibrissa_morphology0.85394437
154MP0003763_abnormal_thymus_physiology0.85366886
155MP0001502_abnormal_circadian_rhythm0.84851317
156MP0000647_abnormal_sebaceous_gland0.84764336
157MP0001986_abnormal_taste_sensitivity0.84350154
158MP0005165_increased_susceptibility_to0.83690326
159MP0009764_decreased_sensitivity_to0.83112692
160MP0002006_tumorigenesis0.82723366
161MP0002736_abnormal_nociception_after0.82498119
162MP0003795_abnormal_bone_structure0.82334565
163MP0002909_abnormal_adrenal_gland0.81916271
164MP0002722_abnormal_immune_system0.80453045
165MP0002429_abnormal_blood_cell0.76929415
166MP0003385_abnormal_body_wall0.76402529
167MP0000767_abnormal_smooth_muscle0.76350783
168MP0008569_lethality_at_weaning0.75236772
169MP0004947_skin_inflammation0.74752273
170MP0003755_abnormal_palate_morphology0.74346732
171MP0005391_vision/eye_phenotype0.74292896
172MP0005647_abnormal_sex_gland0.73933334
173MP0009333_abnormal_splenocyte_physiolog0.72652883
174MP0000427_abnormal_hair_cycle0.72599186
175MP0002277_abnormal_respiratory_mucosa0.72125722
176MP0005197_abnormal_uvea_morphology0.71865092
177MP0001293_anophthalmia0.71574410
178MP0005386_behavior/neurological_phenoty0.71030820
179MP0004924_abnormal_behavior0.71030820
180MP0003634_abnormal_glial_cell0.70914724
181MP0001545_abnormal_hematopoietic_system0.70825045
182MP0005397_hematopoietic_system_phenotyp0.70825045
183MP0004858_abnormal_nervous_system0.70023577
184MP0005164_abnormal_response_to0.69500800
185MP0001790_abnormal_immune_system0.69205455

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.14566474
2Glomerulonephritis (HP:0000099)6.44200981
3Arterial tortuosity (HP:0005116)6.01867866
4Abnormality of liposaccharide metabolism (HP:0010968)5.71758045
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.71758045
6Abnormality of glycolipid metabolism (HP:0010969)5.71758045
7Vascular tortuosity (HP:0004948)5.38262753
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.83953832
9Retinal atrophy (HP:0001105)4.73518574
10Polyphagia (HP:0002591)4.73212542
11Increased cerebral lipofuscin (HP:0011813)4.56359015
12Agitation (HP:0000713)4.42909051
13Complement deficiency (HP:0004431)4.36222256
14Cerebral aneurysm (HP:0004944)4.33329531
15Aortic aneurysm (HP:0004942)4.09010979
16Dysostosis multiplex (HP:0000943)3.88106545
17Gait imbalance (HP:0002141)3.81152250
18Myokymia (HP:0002411)3.78314245
19Nephronophthisis (HP:0000090)3.73935692
20Medial flaring of the eyebrow (HP:0010747)3.72681049
21Polygenic inheritance (HP:0010982)3.63942785
22Spondylolisthesis (HP:0003302)3.60260407
23Mutism (HP:0002300)3.50603723
24Amelogenesis imperfecta (HP:0000705)3.50106609
25Progressive neurologic deterioration (HP:0002344)3.44029597
26Chronic diarrhea (HP:0002028)3.34884160
27Urethral obstruction (HP:0000796)3.33751904
28Vacuolated lymphocytes (HP:0001922)3.31067741
29Aortic dissection (HP:0002647)3.29188613
30Progressive cerebellar ataxia (HP:0002073)3.28364794
31Nephrogenic diabetes insipidus (HP:0009806)3.26216434
32Congenital primary aphakia (HP:0007707)3.25685882
33Abnormality of complement system (HP:0005339)3.25014623
34Onycholysis (HP:0001806)3.23540628
35Partial duplication of thumb phalanx (HP:0009944)3.20758423
36Split foot (HP:0001839)3.19613832
37Recurrent abscess formation (HP:0002722)3.14387617
38Recurrent bacterial skin infections (HP:0005406)3.11760344
39Abnormality of midbrain morphology (HP:0002418)3.10883469
40Molar tooth sign on MRI (HP:0002419)3.10883469
41Orthostatic hypotension (HP:0001278)2.98126117
42Anomalous pulmonary venous return (HP:0010772)2.95443072
43True hermaphroditism (HP:0010459)2.93951535
44Striae distensae (HP:0001065)2.93620154
45Hematochezia (HP:0002573)2.91967082
46Vaginal atresia (HP:0000148)2.91738355
47Abnormality of the renal medulla (HP:0100957)2.88329254
48Limb dystonia (HP:0002451)2.86875805
49Pachygyria (HP:0001302)2.85901616
50Genital tract atresia (HP:0001827)2.85083041
51Nephritis (HP:0000123)2.83791757
52Partial duplication of the phalanx of hand (HP:0009999)2.77296545
53Lissencephaly (HP:0001339)2.76743745
54Urinary glycosaminoglycan excretion (HP:0003541)2.74481919
55Mucopolysacchariduria (HP:0008155)2.74481919
56Pancreatic fibrosis (HP:0100732)2.74170375
57Parakeratosis (HP:0001036)2.73218346
58Abnormal eating behavior (HP:0100738)2.68881847
59Cortical dysplasia (HP:0002539)2.68852369
60Amyloidosis (HP:0011034)2.66421512
61Hepatoblastoma (HP:0002884)2.65888277
62Aplasia/Hypoplasia of the spleen (HP:0010451)2.65196797
63Abnormal pancreas size (HP:0012094)2.62073222
64Agnosia (HP:0010524)2.61950021
65Hepatosplenomegaly (HP:0001433)2.61867477
66Abnormality of the pulmonary veins (HP:0011718)2.60847424
67Disproportionate tall stature (HP:0001519)2.59578881
68Abnormality of polysaccharide metabolism (HP:0011012)2.55937486
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55937486
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55937486
71Drooling (HP:0002307)2.55270436
72Intestinal atresia (HP:0011100)2.55112350
73Asplenia (HP:0001746)2.50862392
74Specific learning disability (HP:0001328)2.43595256
75Lip pit (HP:0100267)2.40697702
76Pancreatic cysts (HP:0001737)2.39911987
77Focal seizures (HP:0007359)2.39328498
78Excessive salivation (HP:0003781)2.39171536
79Abnormality of the corticospinal tract (HP:0002492)2.37626664
80Inappropriate behavior (HP:0000719)2.35987774
81Spastic tetraplegia (HP:0002510)2.34077045
82Hyperventilation (HP:0002883)2.33997476
83Poor coordination (HP:0002370)2.33567445
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32799824
85Chronic hepatic failure (HP:0100626)2.31770631
86Multifactorial inheritance (HP:0001426)2.30657992
87Disinhibition (HP:0000734)2.29201748
88Hip dysplasia (HP:0001385)2.28432593
89Rib fusion (HP:0000902)2.28308436
90Adrenal hypoplasia (HP:0000835)2.25650043
91Anencephaly (HP:0002323)2.25605104
92Hypohidrosis (HP:0000966)2.23165265
93Pathologic fracture (HP:0002756)2.22576530
94Neoplasm of the adrenal cortex (HP:0100641)2.21914646
95Abnormality of the labia minora (HP:0012880)2.21043782
96Soft skin (HP:0000977)2.20361611
97Absent speech (HP:0001344)2.18874912
98Myositis (HP:0100614)2.17011768
99Epileptic encephalopathy (HP:0200134)2.16092804
100Broad-based gait (HP:0002136)2.16092364
101Impaired platelet aggregation (HP:0003540)2.13905665
102Abnormal platelet function (HP:0011869)2.13905665
103Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11972094
104Cardiomegaly (HP:0001640)2.11846748
105Eczematoid dermatitis (HP:0000976)2.11572050
106Abnormality of the aortic arch (HP:0012303)2.11316532
107Failure to thrive in infancy (HP:0001531)2.11242625
108Retinal dysplasia (HP:0007973)2.10409735
109Genetic anticipation (HP:0003743)2.09248474
110Aplasia/Hypoplasia of the lens (HP:0008063)2.07936818
111Hemiparesis (HP:0001269)2.07262694
112Hypoplasia of the brainstem (HP:0002365)2.07192700
113Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07192700
114Amyotrophic lateral sclerosis (HP:0007354)2.06983842
115Basal ganglia calcification (HP:0002135)2.06765128
116Joint stiffness (HP:0001387)2.06676367
117Peripheral hypomyelination (HP:0007182)2.06668135
118Erythema (HP:0010783)2.06341076
119Shawl scrotum (HP:0000049)2.05021168
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03650126
121Septo-optic dysplasia (HP:0100842)2.02879710
122Sleep apnea (HP:0010535)2.01029591
123Retinitis pigmentosa (HP:0000510)2.00145496
124Restlessness (HP:0000711)1.99227011
125Arnold-Chiari malformation (HP:0002308)1.98963613
126Cheilitis (HP:0100825)1.97635419
127Chorioretinal atrophy (HP:0000533)1.97266764
128Abolished electroretinogram (ERG) (HP:0000550)1.96622197
129Premature loss of primary teeth (HP:0006323)1.96391560
130Thrombocytosis (HP:0001894)1.96142952
131Abnormality of the fovea (HP:0000493)1.95019643
132Growth hormone deficiency (HP:0000824)1.94525658
133J-shaped sella turcica (HP:0002680)1.93150585
134Amblyopia (HP:0000646)1.92293902
135Progressive visual loss (HP:0000529)1.91757205
136Thickened calvaria (HP:0002684)1.91101194
137Hypoplasia of the corpus callosum (HP:0002079)1.90604126
138Narrow forehead (HP:0000341)1.90417615
139Intellectual disability, severe (HP:0010864)1.90322895
140Short middle phalanx of the 5th finger (HP:0004220)1.88761402
141Short foot (HP:0001773)1.87348223
142Abnormal rod and cone electroretinograms (HP:0008323)1.87263933
143Bony spicule pigmentary retinopathy (HP:0007737)1.87036282
144Short 4th metacarpal (HP:0010044)1.86304773
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86304773
146Postaxial hand polydactyly (HP:0001162)1.84556889
147Diastasis recti (HP:0001540)1.84302019
148Premature skin wrinkling (HP:0100678)1.83794717
149Fetal akinesia sequence (HP:0001989)1.83000743
150Macular degeneration (HP:0000608)1.82799121
151Type II lissencephaly (HP:0007260)1.82798449
152Elevated erythrocyte sedimentation rate (HP:0003565)1.81804715
153Abnormality of hair growth rate (HP:0011363)1.81694921
154Slow-growing hair (HP:0002217)1.81694921
155Congenital stationary night blindness (HP:0007642)1.81380755
156Bifid uvula (HP:0000193)1.81366992
157Plantar hyperkeratosis (HP:0007556)1.81298128
158Sclerocornea (HP:0000647)1.81012508
159Polymicrogyria (HP:0002126)1.79949152
160Pendular nystagmus (HP:0012043)1.78867062
1613-Methylglutaconic aciduria (HP:0003535)1.78448961
162Dementia (HP:0000726)1.74969640
163Arterial thrombosis (HP:0004420)1.74786950
164Esotropia (HP:0000565)1.74462056
165Megalencephaly (HP:0001355)1.72892061
166Neurofibrillary tangles (HP:0002185)1.72612207
167Urinary bladder sphincter dysfunction (HP:0002839)1.72309177
168Action tremor (HP:0002345)1.72179334
169Hypogonadotrophic hypogonadism (HP:0000044)1.72019096
170Bicuspid aortic valve (HP:0001647)1.71754722
171Abnormal drinking behavior (HP:0030082)1.71471166
172Polydipsia (HP:0001959)1.71471166
173IgM deficiency (HP:0002850)1.70775899
174Broad face (HP:0000283)1.70078499
175Exotropia (HP:0000577)1.69623768
176Mitral valve prolapse (HP:0001634)1.69369753
177Renal dysplasia (HP:0000110)1.69120983
178Craniofacial hyperostosis (HP:0004493)1.67971694
179Aplasia involving bones of the upper limbs (HP:0009823)1.67442116
180Aplasia of the phalanges of the hand (HP:0009802)1.67442116
181Aplasia involving bones of the extremities (HP:0009825)1.67442116
182Recurrent skin infections (HP:0001581)1.66060566
183Sparse eyelashes (HP:0000653)1.65090957
184Macroglossia (HP:0000158)1.64770866
185Neuronal loss in central nervous system (HP:0002529)1.64034337
186Abnormal autonomic nervous system physiology (HP:0012332)1.61006135
187Erectile abnormalities (HP:0100639)1.60657755
188Atrophic scars (HP:0001075)1.59931101
189Ectropion (HP:0000656)1.57927156
190Mixed hearing impairment (HP:0000410)1.56785656
191Colitis (HP:0002583)1.56743860
192Axonal loss (HP:0003447)1.56568280
193Intestinal fistula (HP:0100819)1.54581551
194Cranial hyperostosis (HP:0004437)1.53854364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.70393813
2MARK14.62206182
3MAPK154.51756583
4GRK74.43158240
5CSF1R3.14340397
6EPHB22.74745883
7TSSK62.72886445
8DYRK22.71631318
9MAP2K72.53898861
10MAP3K42.29064944
11VRK12.28809445
12WNK32.16693524
13WNK42.08867417
14TYK21.84984389
15STK161.84062757
16MAPK121.83899037
17STK101.77155069
18MAP4K21.69618756
19PINK11.65315330
20PAK41.64468986
21TYRO31.61755557
22KIT1.61158172
23CLK11.60229808
24IRAK41.59529524
25CDK31.58258708
26CSNK1G21.51394669
27PDK21.49968707
28EEF2K1.44539565
29DYRK31.44035640
30IRAK31.43695026
31YES11.39676731
32DYRK1B1.37290302
33MAPKAPK31.37245835
34PRKCG1.35631242
35NTRK31.34971996
36CAMK1D1.34753127
37CDK191.33674950
38MINK11.33174945
39MAP2K41.32562427
40SGK4941.30522545
41SGK2231.30522545
42CDK81.30164491
43ADRBK21.29853926
44MARK21.27733593
45PAK31.26451342
46ERBB31.24217286
47BCR1.24085573
48EPHA31.23726028
49MAPK71.15774582
50RIPK41.14983556
51MOS1.11769141
52CSNK1G31.11474871
53CSNK1A1L1.10822134
54EPHA41.10266040
55CAMKK11.08333842
56BTK1.07989189
57BMPR1B1.07224665
58ZAK1.06774305
59ITK1.02866793
60TNIK0.99418779
61PIM20.98961869
62LYN0.98029240
63TRPM70.97780312
64MAPKAPK50.97073900
65TAOK30.95867545
66HCK0.94616460
67GRK10.93568109
68TEC0.92558905
69JAK10.90591502
70MAP3K30.89841766
71DYRK1A0.88609453
72FLT30.87440030
73ZAP700.86715419
74BLK0.86094771
75TXK0.85252109
76TNK20.84873458
77MAP4K10.84727969
78TGFBR10.83873987
79PIK3CG0.82969701
80SIK30.82093877
81CDK50.82070391
82CSNK1G10.81855515
83PTK60.81473277
84CAMK1G0.80874720
85SYK0.79558570
86BCKDK0.79548864
87TBK10.78619340
88PNCK0.78037318
89MAP3K110.78020353
90EIF2AK20.77920510
91PKN10.77513927
92STK390.76402449
93MAP2K30.74798363
94INSRR0.74494484
95SGK20.73845987
96LIMK10.73755921
97JAK20.71792444
98PRKCZ0.71126109
99IGF1R0.69951464
100FES0.69638761
101PRKCH0.69257601
102LCK0.68595986
103CAMKK20.67756946
104GRK50.66937885
105MAP3K140.66871846
106ERN10.64259494
107PAK60.62266473
108STK240.62001941
109RPS6KA20.61979025
110STK110.61868806
111MATK0.60008366
112MAPKAPK20.59163947
113MAPK130.58955303
114MKNK20.55334547
115MAPK40.55193347
116PKN20.54166835
117CAMK40.54108043
118MKNK10.53796976
119MAP3K90.53321644
120UHMK10.53218998
121PRKCE0.51663637
122PAK20.51342893
123PRKACA0.51151123
124MAP3K60.50163197
125RPS6KA60.49903870
126CCNB10.49262210
127FGFR20.49074018
128DAPK20.46247823
129KSR10.45974735
130BRAF0.45919162
131RPS6KB20.45743132
132PRKD30.44111229
133FRK0.43269234
134MAP2K60.43031662
135SIK20.42792892
136SIK10.41421213
137ICK0.41026044
138CAMK2A0.40666337
139CDK140.39986008
140CASK0.39588056
141PRKCQ0.38506192
142PHKG10.37679798
143PHKG20.37679798
144SGK30.37655619
145IKBKB0.37151766
146NTRK20.36819383
147RPS6KL10.36393263
148RPS6KC10.36393263
149CAMK10.36296957
150ADRBK10.36198007
151PLK30.34795776
152LMTK20.34700924
153PRKD20.34578835
154SGK10.34535854
155ABL20.34312357
156DDR20.33280466
157FGFR30.33011818
158DMPK0.32132713
159ERBB20.32128278
160PRKG10.31964815
161CDK60.31404297
162JAK30.31154249
163ACVR1B0.30099074
164MARK30.29305720
165CSK0.28923113

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.88484360
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.46423616
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.12282026
4Staphylococcus aureus infection_Homo sapiens_hsa051503.63847887
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.44322000
6Nicotine addiction_Homo sapiens_hsa050333.23347790
7Phototransduction_Homo sapiens_hsa047442.76085168
8Lysosome_Homo sapiens_hsa041422.58887474
9Morphine addiction_Homo sapiens_hsa050322.56320649
10Collecting duct acid secretion_Homo sapiens_hsa049662.46690308
11Axon guidance_Homo sapiens_hsa043602.33481901
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.30934657
13Osteoclast differentiation_Homo sapiens_hsa043802.29085036
14Glutamatergic synapse_Homo sapiens_hsa047242.16458732
15Oxidative phosphorylation_Homo sapiens_hsa001902.15065505
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.14775407
17GABAergic synapse_Homo sapiens_hsa047272.14230718
18Synaptic vesicle cycle_Homo sapiens_hsa047212.08746231
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.07501746
20Leishmaniasis_Homo sapiens_hsa051401.98934767
21Pertussis_Homo sapiens_hsa051331.98665341
22Dopaminergic synapse_Homo sapiens_hsa047281.96891538
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95315948
24Circadian entrainment_Homo sapiens_hsa047131.83959977
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.83713645
26Cardiac muscle contraction_Homo sapiens_hsa042601.82966302
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.78606293
28Cholinergic synapse_Homo sapiens_hsa047251.76963568
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76227559
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68190051
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.65154314
32B cell receptor signaling pathway_Homo sapiens_hsa046621.62055042
33Prion diseases_Homo sapiens_hsa050201.54206449
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51326034
35Parkinsons disease_Homo sapiens_hsa050121.50105452
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.47955520
37Toxoplasmosis_Homo sapiens_hsa051451.46267660
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43877661
39Antigen processing and presentation_Homo sapiens_hsa046121.42455036
40Legionellosis_Homo sapiens_hsa051341.37420930
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37266329
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.34513749
43N-Glycan biosynthesis_Homo sapiens_hsa005101.33255442
44Insulin secretion_Homo sapiens_hsa049111.31345875
45Basal cell carcinoma_Homo sapiens_hsa052171.31128043
46Sphingolipid metabolism_Homo sapiens_hsa006001.29290905
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.27284182
48Colorectal cancer_Homo sapiens_hsa052101.26775792
49Oxytocin signaling pathway_Homo sapiens_hsa049211.26060820
50Pancreatic cancer_Homo sapiens_hsa052121.24140332
51Hematopoietic cell lineage_Homo sapiens_hsa046401.20476406
52Hedgehog signaling pathway_Homo sapiens_hsa043401.18955877
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15948011
54Arachidonic acid metabolism_Homo sapiens_hsa005901.15883235
55Tuberculosis_Homo sapiens_hsa051521.14725475
56Chronic myeloid leukemia_Homo sapiens_hsa052201.13926361
57Long-term depression_Homo sapiens_hsa047301.12668373
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10750991
59Notch signaling pathway_Homo sapiens_hsa043301.08453977
60Malaria_Homo sapiens_hsa051441.04427156
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04131262
62Linoleic acid metabolism_Homo sapiens_hsa005911.01343473
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00987437
64Vibrio cholerae infection_Homo sapiens_hsa051101.00371356
65Influenza A_Homo sapiens_hsa051640.99359694
66Platelet activation_Homo sapiens_hsa046110.98745838
67Alzheimers disease_Homo sapiens_hsa050100.97419673
68Ether lipid metabolism_Homo sapiens_hsa005650.96622200
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95414741
70Ras signaling pathway_Homo sapiens_hsa040140.95107189
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93126361
72Hepatitis B_Homo sapiens_hsa051610.92609765
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90993820
74Salmonella infection_Homo sapiens_hsa051320.89513362
75Taste transduction_Homo sapiens_hsa047420.86955322
76Huntingtons disease_Homo sapiens_hsa050160.86940411
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.86622374
78Gap junction_Homo sapiens_hsa045400.86366829
79Regulation of autophagy_Homo sapiens_hsa041400.84714794
80Measles_Homo sapiens_hsa051620.83677725
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82778994
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80998825
83Olfactory transduction_Homo sapiens_hsa047400.78457227
84Gastric acid secretion_Homo sapiens_hsa049710.78058306
85Steroid biosynthesis_Homo sapiens_hsa001000.77541256
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76590184
87Butanoate metabolism_Homo sapiens_hsa006500.76005410
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75894209
89Dorso-ventral axis formation_Homo sapiens_hsa043200.75261700
90Amphetamine addiction_Homo sapiens_hsa050310.73978512
91Chemokine signaling pathway_Homo sapiens_hsa040620.72808789
92Rheumatoid arthritis_Homo sapiens_hsa053230.70419135
93Ovarian steroidogenesis_Homo sapiens_hsa049130.70229269
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.69112572
95TGF-beta signaling pathway_Homo sapiens_hsa043500.68990305
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68188932
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66818130
98Endocytosis_Homo sapiens_hsa041440.66205677
99African trypanosomiasis_Homo sapiens_hsa051430.65863002
100Nitrogen metabolism_Homo sapiens_hsa009100.65811888
101Adherens junction_Homo sapiens_hsa045200.65040525
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64271730
103Phagosome_Homo sapiens_hsa041450.63500545
104Fatty acid biosynthesis_Homo sapiens_hsa000610.63441000
105Melanogenesis_Homo sapiens_hsa049160.61358088
106TNF signaling pathway_Homo sapiens_hsa046680.61172127
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59853722
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.58859038
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58835567
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.58473403
111Hippo signaling pathway_Homo sapiens_hsa043900.58325159
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.58272298
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58165703
114Type II diabetes mellitus_Homo sapiens_hsa049300.57364965
115Apoptosis_Homo sapiens_hsa042100.56598015
116Wnt signaling pathway_Homo sapiens_hsa043100.56432217
117ABC transporters_Homo sapiens_hsa020100.56110545
118Melanoma_Homo sapiens_hsa052180.55450723
119Cocaine addiction_Homo sapiens_hsa050300.53115361
120Calcium signaling pathway_Homo sapiens_hsa040200.53094584
121Circadian rhythm_Homo sapiens_hsa047100.51389496
122Rap1 signaling pathway_Homo sapiens_hsa040150.49811164
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.49548246
124Estrogen signaling pathway_Homo sapiens_hsa049150.48922005
125HTLV-I infection_Homo sapiens_hsa051660.48516369
126Protein export_Homo sapiens_hsa030600.47929446
127Pathways in cancer_Homo sapiens_hsa052000.47596093
128Dilated cardiomyopathy_Homo sapiens_hsa054140.47123273
129Herpes simplex infection_Homo sapiens_hsa051680.45451275
130Shigellosis_Homo sapiens_hsa051310.44776863
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42833150
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41564445
133Salivary secretion_Homo sapiens_hsa049700.41321259
134Non-small cell lung cancer_Homo sapiens_hsa052230.40727161
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40246573
136Complement and coagulation cascades_Homo sapiens_hsa046100.38686621
137Renin secretion_Homo sapiens_hsa049240.37990631
138Basal transcription factors_Homo sapiens_hsa030220.36931580
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36317662
140cAMP signaling pathway_Homo sapiens_hsa040240.35482748
141FoxO signaling pathway_Homo sapiens_hsa040680.34757081
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33651911
143Acute myeloid leukemia_Homo sapiens_hsa052210.33582290
144Peroxisome_Homo sapiens_hsa041460.33320878
145MAPK signaling pathway_Homo sapiens_hsa040100.33235758
146VEGF signaling pathway_Homo sapiens_hsa043700.32610783
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32473049
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.31512825
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31162480
150GnRH signaling pathway_Homo sapiens_hsa049120.30474963
151Amoebiasis_Homo sapiens_hsa051460.29433794
152Epstein-Barr virus infection_Homo sapiens_hsa051690.29415908
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29356199
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29337989
155Glioma_Homo sapiens_hsa052140.28980642
156Serotonergic synapse_Homo sapiens_hsa047260.27011742
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24482943
158Phospholipase D signaling pathway_Homo sapiens_hsa040720.23966853
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23488668
160Hepatitis C_Homo sapiens_hsa051600.23195282
161Inositol phosphate metabolism_Homo sapiens_hsa005620.22473913

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