GAL3ST1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. This gene encodes galactosylceramide sulfotransferase, which catalyzes the sulfation of membrane glycolipids including the final step in the synthesis of sulfatide, a major lipid component of the myelin sheath. This gene exhibits elevated expression in ovarian epithelial carcinoma and the encoded enzyme exhibits elevated activity in renal cell carcinoma. Mutations in this gene may be associated with reduced insulin resistance. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.70795487
2* ensheathment of neurons (GO:0007272)6.90173368
3* axon ensheathment (GO:0008366)6.90173368
4* myelination (GO:0042552)6.81476165
5long-chain fatty acid biosynthetic process (GO:0042759)6.41746003
6cholesterol biosynthetic process (GO:0006695)5.97762130
7myelin maintenance (GO:0043217)5.24482228
8sterol biosynthetic process (GO:0016126)5.24024821
9negative regulation of neurotransmitter secretion (GO:0046929)5.04560348
10phosphate ion transmembrane transport (GO:0035435)4.96977625
11urate metabolic process (GO:0046415)4.94265634
12regulation of cholesterol esterification (GO:0010872)4.89240743
13high-density lipoprotein particle remodeling (GO:0034375)4.87667377
14negative regulation of neurotransmitter transport (GO:0051589)4.65977081
15long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.62785207
16phospholipid efflux (GO:0033700)4.58562050
17isoprenoid biosynthetic process (GO:0008299)4.56315245
18oligodendrocyte differentiation (GO:0048709)4.52886067
19creatine metabolic process (GO:0006600)4.49266052
20reverse cholesterol transport (GO:0043691)4.46646571
21phosphate ion transport (GO:0006817)4.45958055
22negative regulation of cholesterol transport (GO:0032375)4.44074841
23negative regulation of sterol transport (GO:0032372)4.44074841
24response to methylmercury (GO:0051597)4.43823110
25regulation of collateral sprouting (GO:0048670)4.39159632
26long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.36360412
27proline metabolic process (GO:0006560)4.34825264
28glycerophospholipid catabolic process (GO:0046475)4.33910539
29negative regulation of protein localization to cell surface (GO:2000009)4.30705091
30amyloid precursor protein metabolic process (GO:0042982)4.22095392
31establishment of mitochondrion localization (GO:0051654)4.18372896
32apical protein localization (GO:0045176)4.18086537
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.17160922
34artery smooth muscle contraction (GO:0014824)4.15087629
35photoreceptor cell differentiation (GO:0046530)4.14761105
36eye photoreceptor cell differentiation (GO:0001754)4.14761105
37substantia nigra development (GO:0021762)4.08250865
38asymmetric protein localization (GO:0008105)4.07534076
39fatty-acyl-CoA biosynthetic process (GO:0046949)4.06263831
404-hydroxyproline metabolic process (GO:0019471)4.03697358
41drug transmembrane transport (GO:0006855)4.03003265
42response to redox state (GO:0051775)3.98533525
43adhesion of symbiont to host cell (GO:0044650)3.91967130
44virion attachment to host cell (GO:0019062)3.91967130
45plasma lipoprotein particle assembly (GO:0034377)3.87220972
46positive regulation of oligodendrocyte differentiation (GO:0048714)3.85469420
47fatty-acyl-CoA metabolic process (GO:0035337)3.83744452
48cholesterol efflux (GO:0033344)3.83521873
49astrocyte development (GO:0014002)3.82974563
50glyoxylate metabolic process (GO:0046487)3.82726163
51plasma lipoprotein particle remodeling (GO:0034369)3.82512842
52protein-lipid complex remodeling (GO:0034368)3.82512842
53macromolecular complex remodeling (GO:0034367)3.82512842
54response to lipoprotein particle (GO:0055094)3.80108867
55L-amino acid import (GO:0043092)3.77028564
56myelination in peripheral nervous system (GO:0022011)3.73354374
57peripheral nervous system axon ensheathment (GO:0032292)3.73354374
58presynaptic membrane organization (GO:0097090)3.72394958
59peptidyl-tyrosine autophosphorylation (GO:0038083)3.69813740
60very long-chain fatty acid metabolic process (GO:0000038)3.68116620
61intestinal cholesterol absorption (GO:0030299)3.67930119
62protein-lipid complex assembly (GO:0065005)3.67676982
63tonic smooth muscle contraction (GO:0014820)3.67130370
64very-low-density lipoprotein particle assembly (GO:0034379)3.66236491
65negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.61062370
66regulation of bile acid biosynthetic process (GO:0070857)3.55985770
67presynaptic membrane assembly (GO:0097105)3.55803881
68L-phenylalanine metabolic process (GO:0006558)3.54782909
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54782909
70cellular glucuronidation (GO:0052695)3.52749232
71regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.51929319
72drug transport (GO:0015893)3.48376666
73import into cell (GO:0098657)3.45418284
74protein palmitoylation (GO:0018345)3.45287025
75uronic acid metabolic process (GO:0006063)3.42528884
76glucuronate metabolic process (GO:0019585)3.42528884
77flavonoid metabolic process (GO:0009812)3.41365952
78nephron tubule formation (GO:0072079)3.37487786
79regulation of lipoprotein metabolic process (GO:0050746)3.37438488
80nucleotide transmembrane transport (GO:1901679)3.34654140
81acyl-CoA biosynthetic process (GO:0071616)3.31496574
82thioester biosynthetic process (GO:0035384)3.31496574
83magnesium ion transport (GO:0015693)3.29155499
84regulation of apoptotic process involved in morphogenesis (GO:1902337)3.27155432
85serine family amino acid biosynthetic process (GO:0009070)3.23488471
86amyloid precursor protein catabolic process (GO:0042987)3.22876325
87GPI anchor biosynthetic process (GO:0006506)3.21403515
88regulation of systemic arterial blood pressure by hormone (GO:0001990)3.18880684
89regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.18880684
90endocrine process (GO:0050886)3.18880684
91toxin transport (GO:1901998)3.17377782
92membrane tubulation (GO:0097320)3.17311430
93plasma lipoprotein particle clearance (GO:0034381)3.16542336
94angiotensin maturation (GO:0002003)3.15738917
95regulation of triglyceride catabolic process (GO:0010896)3.14948775
96axon development (GO:0061564)3.12083194
97GPI anchor metabolic process (GO:0006505)3.11782664
98aldehyde catabolic process (GO:0046185)3.09212399
99negative regulation of fatty acid biosynthetic process (GO:0045717)3.08714919
100proline biosynthetic process (GO:0006561)3.06268435
101negative regulation of axonogenesis (GO:0050771)3.03604340
102intestinal absorption (GO:0050892)3.01638183
103cysteine metabolic process (GO:0006534)3.01554912
104plasma lipoprotein particle organization (GO:0071827)2.98429367
105L-ascorbic acid metabolic process (GO:0019852)2.97621120
106protein carboxylation (GO:0018214)2.97009211
107peptidyl-glutamic acid carboxylation (GO:0017187)2.97009211
108glutamate metabolic process (GO:0006536)2.93755451
109limb bud formation (GO:0060174)2.93397925
110protein-lipid complex subunit organization (GO:0071825)2.93150319
111negative regulation of lipase activity (GO:0060192)2.92900489
112peripheral nervous system development (GO:0007422)2.92872237
113cellular response to epinephrine stimulus (GO:0071872)2.90811752
114lipoprotein metabolic process (GO:0042157)2.88448935
115glutamine family amino acid biosynthetic process (GO:0009084)2.88000112
116regulation of extracellular matrix disassembly (GO:0010715)2.87935802
117adhesion of symbiont to host (GO:0044406)2.86827275
118negative regulation of metanephros development (GO:0072217)2.86786987
119amino acid import (GO:0043090)2.85555035
120acylglycerol homeostasis (GO:0055090)2.85419626
121triglyceride homeostasis (GO:0070328)2.85419626
122peptidyl-cysteine modification (GO:0018198)2.83207016
123cellular modified amino acid catabolic process (GO:0042219)2.83191764
124neuron cell-cell adhesion (GO:0007158)2.83176125
125positive regulation of cellular amine metabolic process (GO:0033240)2.79584659
126cell-cell junction maintenance (GO:0045217)2.77724901
127adult walking behavior (GO:0007628)2.77404300
128neural nucleus development (GO:0048857)2.76483878
129diacylglycerol metabolic process (GO:0046339)2.75102156
130transmission of nerve impulse (GO:0019226)2.74744040
131drug metabolic process (GO:0017144)2.74532015
132preassembly of GPI anchor in ER membrane (GO:0016254)2.73595098
133response to hepatocyte growth factor (GO:0035728)2.73172225
134cellular response to hepatocyte growth factor stimulus (GO:0035729)2.73172225
135negative regulation of fatty acid metabolic process (GO:0045922)2.72885457
136leukocyte migration involved in inflammatory response (GO:0002523)2.72869127
137glutathione biosynthetic process (GO:0006750)2.72352631
138neuronal action potential propagation (GO:0019227)2.71111627
139lung epithelium development (GO:0060428)2.71053201
140glucose 6-phosphate metabolic process (GO:0051156)2.71021242
141metanephric tubule development (GO:0072170)2.70631009
142metanephric nephron tubule development (GO:0072234)2.70631009
143positive regulation of action potential (GO:0045760)2.70566926
144iron coordination entity transport (GO:1901678)2.70176259
145cholesterol homeostasis (GO:0042632)2.69823808
146cerebral cortex radially oriented cell migration (GO:0021799)2.69510788
147carbohydrate derivative transport (GO:1901264)2.69415240
148regulation of systemic arterial blood pressure (GO:0003073)2.68824510
149positive regulation of actin filament depolymerization (GO:0030836)2.67076523
150response to epinephrine (GO:0071871)2.66390154
151negative regulation of JUN kinase activity (GO:0043508)2.65457151
152alcohol biosynthetic process (GO:0046165)2.65213568
153regulation of cholesterol metabolic process (GO:0090181)2.64826283
154metanephric nephron epithelium development (GO:0072243)2.64111744
155low-density lipoprotein particle remodeling (GO:0034374)2.63512348
156sterol homeostasis (GO:0055092)2.63005209
157neuron remodeling (GO:0016322)2.62586399
158cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.61633250
159glial cell development (GO:0021782)2.60913095
160heme transport (GO:0015886)2.59873818
161vitamin transport (GO:0051180)2.59516099
162negative regulation of axon extension (GO:0030517)2.58908494
163negative regulation of execution phase of apoptosis (GO:1900118)2.58098691
164epoxygenase P450 pathway (GO:0019373)2.57249197
165positive regulation of glial cell differentiation (GO:0045687)2.56530132
166positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.56312375
167nerve growth factor signaling pathway (GO:0038180)2.55898915
168positive regulation of steroid metabolic process (GO:0045940)2.55370717
169interleukin-6-mediated signaling pathway (GO:0070102)2.55247799
170regulation of plasminogen activation (GO:0010755)2.55060051
171mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.54971305
172peptide hormone processing (GO:0016486)2.54818228
173protein neddylation (GO:0045116)2.54799228
174cholesterol metabolic process (GO:0008203)2.54166727
175nonribosomal peptide biosynthetic process (GO:0019184)2.53363987
176enteric nervous system development (GO:0048484)2.53259372
177metanephric epithelium development (GO:0072207)2.52827501
178glial cell differentiation (GO:0010001)2.52492352
179negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.52069914
180positive regulation of pseudopodium assembly (GO:0031274)2.51182375
181erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.50941005
182L-phenylalanine catabolic process (GO:0006559)2.50941005
183regulation of guanylate cyclase activity (GO:0031282)2.50788943
184regulation of cholesterol homeostasis (GO:2000188)2.50767466
185regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.50746495
186embryonic retina morphogenesis in camera-type eye (GO:0060059)2.49808036
187basic amino acid transport (GO:0015802)2.49323586
188phosphatidylserine metabolic process (GO:0006658)2.48020218
189axon ensheathment in central nervous system (GO:0032291)11.1268468
190central nervous system myelination (GO:0022010)11.1268468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62270772
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.25699497
3GBX2_23144817_ChIP-Seq_PC3_Human3.10348238
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.06391316
5RXR_22158963_ChIP-Seq_LIVER_Mouse2.90607217
6SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.77469764
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57022611
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.41360854
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25485066
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17096057
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.16954782
12TAF15_26573619_Chip-Seq_HEK293_Human2.16326667
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15184384
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14533347
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.11990779
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09431504
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.08850962
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05937570
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.05825456
20FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02142209
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99816872
22* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96782427
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96441670
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95427945
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90700090
26CTCF_27219007_Chip-Seq_Bcells_Human1.90670823
27VDR_22108803_ChIP-Seq_LS180_Human1.85867825
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85164048
29NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.84059856
30* LXR_22292898_ChIP-Seq_THP-1_Human1.83366410
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81089720
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80680131
33* EZH2_27304074_Chip-Seq_ESCs_Mouse1.78552655
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76721324
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76721324
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76515427
37EZH2_22144423_ChIP-Seq_EOC_Human1.76280536
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75854017
39ER_23166858_ChIP-Seq_MCF-7_Human1.75371965
40* EZH2_27294783_Chip-Seq_ESCs_Mouse1.74430642
41AR_21572438_ChIP-Seq_LNCaP_Human1.70685146
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.69765494
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67471233
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66691603
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63325388
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63196985
47CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62877366
48PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61095651
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.58016889
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.53484124
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52235685
52STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.51976495
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.49795543
54DROSHA_22980978_ChIP-Seq_HELA_Human1.48681248
55SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47782825
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.46954972
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.45037857
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.44799691
59SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44381210
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.39092516
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.38377531
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37293324
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36434417
64* RNF2_27304074_Chip-Seq_ESCs_Mouse1.36344032
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35950689
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35874944
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35194928
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34964094
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33881170
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33241125
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31682222
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31500837
73* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31457117
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30431918
75KDM2B_26808549_Chip-Seq_K562_Human1.29388164
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28439997
77* HNF4A_19822575_ChIP-Seq_HepG2_Human1.28072987
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.26148113
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.26110086
80SOX2_20726797_ChIP-Seq_SW620_Human1.24675573
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24083277
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23166175
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23166175
84ESR1_21235772_ChIP-Seq_MCF-7_Human1.23044403
85EP300_21415370_ChIP-Seq_HL-1_Mouse1.20643559
86FUS_26573619_Chip-Seq_HEK293_Human1.18653865
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18081429
88BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17291344
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16869609
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16568598
91CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15071481
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14994132
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.14977078
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13716409
95RING1B_27294783_Chip-Seq_ESCs_Mouse1.11842999
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.11316971
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.10733965
98GATA4_25053715_ChIP-Seq_YYC3_Human1.10402586
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.10342885
100RACK7_27058665_Chip-Seq_MCF-7_Human1.10058913
101* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09342973
102EOMES_21245162_ChIP-Seq_HESCs_Human1.08547029
103SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.08359806
104P300_19829295_ChIP-Seq_ESCs_Human1.07698953
105TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.07281484
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07161265
107P68_20966046_ChIP-Seq_HELA_Human1.06491835
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06083456
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.06073330
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05161197
111LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04980862
112CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04344543
113HTT_18923047_ChIP-ChIP_STHdh_Human1.03905157
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03810460
115STAT3_23295773_ChIP-Seq_U87_Human1.03152319
116RARB_27405468_Chip-Seq_BRAIN_Mouse1.02638796
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.00716335
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.99993745
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99917945
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99135919
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98999380
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97712023
123SA1_27219007_Chip-Seq_Bcells_Human0.97590666
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96936429
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96100903
126ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95920567
127SMC4_20622854_ChIP-Seq_HELA_Human0.95520264
128WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95465553
129NANOG_18555785_Chip-Seq_ESCs_Mouse0.95189845
130RARA_24833708_ChIP-Seq_LIVER_Mouse0.95174849
131POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95132562
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95074833
133P300_18555785_Chip-Seq_ESCs_Mouse0.94332266
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93276997
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93211468
136AHR_22903824_ChIP-Seq_MCF-7_Human0.93142935
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92558913
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.92495654
139FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92245136
140SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91685615
141TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91087027
142REST_21632747_ChIP-Seq_MESCs_Mouse0.90826429
143TCF4_23295773_ChIP-Seq_U87_Human0.89211878
144TET1_21490601_ChIP-Seq_MESCs_Mouse0.89191147
145SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.88983085
146TP53_22127205_ChIP-Seq_IMR90_Human0.88802406
147CTCF_20526341_ChIP-Seq_ESCs_Human0.88730925
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.88127887
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87879436
150RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87436165
151ARNT_22903824_ChIP-Seq_MCF-7_Human0.87286179
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86668662
153TBL1_22424771_ChIP-Seq_293T_Human0.86448077
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.86225502
155OCT4_19829295_ChIP-Seq_ESCs_Human0.85999950
156TP63_22573176_ChIP-Seq_HFKS_Human0.85829830
157TP63_17297297_ChIP-ChIP_HaCaT_Human0.85251722
158SMAD4_21799915_ChIP-Seq_A2780_Human0.84987737
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84962626
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84933958
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84929968
162NANOG_19829295_ChIP-Seq_ESCs_Human0.84680714
163SOX2_19829295_ChIP-Seq_ESCs_Human0.84680714
164* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83164160
165UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82684723
166SMAD4_21741376_ChIP-Seq_EPCs_Human0.82128236
167RNF2_27304074_Chip-Seq_NSC_Mouse0.81887984
168JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80631948
169CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80595845
170MYC_19915707_ChIP-ChIP_AK7_Human0.80178531
171SOX2_21211035_ChIP-Seq_LN229_Human0.79806782
172CREB1_26743006_Chip-Seq_LNCaP_Human0.79426568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.30616946
2MP0005360_urolithiasis5.74170659
3* MP0000920_abnormal_myelination5.62003224
4MP0003950_abnormal_plasma_membrane3.47295387
5MP0003880_abnormal_central_pattern3.45548597
6MP0004270_analgesia3.30749847
7MP0003690_abnormal_glial_cell3.25829581
8MP0005084_abnormal_gallbladder_morpholo3.25548854
9MP0005083_abnormal_biliary_tract2.96965003
10MP0005365_abnormal_bile_salt2.87886032
11MP0003329_amyloid_beta_deposits2.86403928
12MP0004742_abnormal_vestibular_system2.72348203
13MP0003136_yellow_coat_color2.72184278
14MP0005085_abnormal_gallbladder_physiolo2.71050067
15MP0004885_abnormal_endolymph2.67924764
16MP0001529_abnormal_vocalization2.63373665
17MP0004019_abnormal_vitamin_homeostasis2.62681238
18MP0003634_abnormal_glial_cell2.50645633
19MP0005451_abnormal_body_composition2.42541431
20MP0001905_abnormal_dopamine_level2.42467168
21MP0002272_abnormal_nervous_system2.36328503
22MP0005332_abnormal_amino_acid2.34677064
23MP0001485_abnormal_pinna_reflex2.31273112
24MP0001486_abnormal_startle_reflex2.27562008
25MP0004043_abnormal_pH_regulation2.27144595
26MP0000462_abnormal_digestive_system2.25445796
27MP0003879_abnormal_hair_cell2.20374342
28MP0003183_abnormal_peptide_metabolism2.18701260
29MP0005171_absent_coat_pigmentation2.15767793
30MP0003806_abnormal_nucleotide_metabolis2.15180010
31MP0001666_abnormal_nutrient_absorption2.14459503
32MP0004142_abnormal_muscle_tone2.13805503
33MP0010329_abnormal_lipoprotein_level2.12898009
34MP0005409_darkened_coat_color2.07697383
35MP0010386_abnormal_urinary_bladder2.06467699
36MP0003632_abnormal_nervous_system2.01050928
37MP0010678_abnormal_skin_adnexa1.99431025
38MP0000778_abnormal_nervous_system1.98861374
39MP0002064_seizures1.92097573
40MP0003122_maternal_imprinting1.88492617
41MP0002138_abnormal_hepatobiliary_system1.84239479
42MP0004381_abnormal_hair_follicle1.83200819
43MP0002229_neurodegeneration1.83040562
44MP0000383_abnormal_hair_follicle1.77343372
45MP0003195_calcinosis1.77090033
46MP0005410_abnormal_fertilization1.76607301
47MP0003252_abnormal_bile_duct1.75715423
48MP0002089_abnormal_postnatal_growth/wei1.75169732
49MP0002928_abnormal_bile_duct1.75115560
50MP0005423_abnormal_somatic_nervous1.69139666
51MP0002734_abnormal_mechanical_nocicepti1.59631865
52MP0002822_catalepsy1.55269086
53MP0000604_amyloidosis1.50939026
54MP0001756_abnormal_urination1.50644265
55MP0009046_muscle_twitch1.48383467
56MP0004147_increased_porphyrin_level1.46740612
57MP0004134_abnormal_chest_morphology1.44966393
58MP0004133_heterotaxia1.44699991
59MP0002909_abnormal_adrenal_gland1.43946922
60MP0008875_abnormal_xenobiotic_pharmacok1.41407657
61MP0009780_abnormal_chondrocyte_physiolo1.40232191
62MP0003631_nervous_system_phenotype1.39449215
63MP0009745_abnormal_behavioral_response1.39123798
64MP0004859_abnormal_synaptic_plasticity1.38115191
65MP0000678_abnormal_parathyroid_gland1.38005044
66MP0003283_abnormal_digestive_organ1.35187273
67MP0009643_abnormal_urine_homeostasis1.31141858
68MP0000955_abnormal_spinal_cord1.30599769
69MP0003635_abnormal_synaptic_transmissio1.30482355
70MP0001661_extended_life_span1.27804724
71MP0005670_abnormal_white_adipose1.26157694
72MP0005551_abnormal_eye_electrophysiolog1.25984955
73MP0001963_abnormal_hearing_physiology1.25949851
74MP0002876_abnormal_thyroid_physiology1.25124297
75* MP0002882_abnormal_neuron_morphology1.22388511
76MP0000647_abnormal_sebaceous_gland1.19830403
77MP0000747_muscle_weakness1.18581685
78MP0005408_hypopigmentation1.12619959
79* MP0002066_abnormal_motor_capabilities/c1.11416643
80MP0008260_abnormal_autophagy1.11061122
81MP0001346_abnormal_lacrimal_gland1.10261249
82MP0001970_abnormal_pain_threshold1.10120988
83MP0001299_abnormal_eye_distance/1.10066597
84MP0000639_abnormal_adrenal_gland1.09711191
85MP0005058_abnormal_lysosome_morphology1.09232438
86MP0001440_abnormal_grooming_behavior1.08857917
87MP0003633_abnormal_nervous_system1.08373302
88MP0002752_abnormal_somatic_nervous1.06381267
89MP0002067_abnormal_sensory_capabilities1.06087920
90MP0002572_abnormal_emotion/affect_behav1.05820947
91MP0001851_eye_inflammation1.01146643
92MP0000013_abnormal_adipose_tissue1.01099951
93MP0008569_lethality_at_weaning1.00686859
94MP0002733_abnormal_thermal_nociception0.98116194
95MP0009379_abnormal_foot_pigmentation0.97581998
96MP0005623_abnormal_meninges_morphology0.96661400
97MP0002254_reproductive_system_inflammat0.96602883
98MP0000467_abnormal_esophagus_morphology0.96513506
99MP0002063_abnormal_learning/memory/cond0.95212596
100MP0001944_abnormal_pancreas_morphology0.93915190
101MP0005386_behavior/neurological_phenoty0.93244799
102MP0004924_abnormal_behavior0.93244799
103MP0002557_abnormal_social/conspecific_i0.93212718
104MP0004858_abnormal_nervous_system0.92194348
105MP0000762_abnormal_tongue_morphology0.91877178
106MP0003938_abnormal_ear_development0.90189539
107MP0005195_abnormal_posterior_eye0.89767555
108MP0010030_abnormal_orbit_morphology0.88796640
109MP0002295_abnormal_pulmonary_circulatio0.88786991
110MP0005636_abnormal_mineral_homeostasis0.88549181
111MP0001502_abnormal_circadian_rhythm0.88266233
112MP0000566_synostosis0.87684077
113MP0004264_abnormal_extraembryonic_tissu0.87506595
114MP0003937_abnormal_limbs/digits/tail_de0.86142736
115MP0000538_abnormal_urinary_bladder0.84850842
116MP0008438_abnormal_cutaneous_collagen0.84118248
117MP0008872_abnormal_physiological_respon0.82856676
118MP0003123_paternal_imprinting0.81754773
119MP0001177_atelectasis0.81533694
120MP0001968_abnormal_touch/_nociception0.79190152
121MP0001764_abnormal_homeostasis0.78689028
122MP0000026_abnormal_inner_ear0.78429719
123MP0001765_abnormal_ion_homeostasis0.77768792
124MP0001664_abnormal_digestion0.77348389
125MP0005645_abnormal_hypothalamus_physiol0.75785120
126MP0002796_impaired_skin_barrier0.75241861
127MP0009840_abnormal_foam_cell0.75085552
128MP0004272_abnormal_basement_membrane0.74095731
129MP0003718_maternal_effect0.73858547
130MP0002249_abnormal_larynx_morphology0.73640157
131MP0003011_delayed_dark_adaptation0.73512654
132MP0000579_abnormal_nail_morphology0.73271222
133MP0004145_abnormal_muscle_electrophysio0.72411466
134MP0001986_abnormal_taste_sensitivity0.71463721
135MP0005220_abnormal_exocrine_pancreas0.70949567
136MP0005375_adipose_tissue_phenotype0.70758003
137MP0003119_abnormal_digestive_system0.70701258
138MP0006072_abnormal_retinal_apoptosis0.70398754
139MP0005379_endocrine/exocrine_gland_phen0.69743496
140MP0001984_abnormal_olfaction0.69590123
141MP0002090_abnormal_vision0.67881876
142MP0003953_abnormal_hormone_level0.67768931
143MP0005253_abnormal_eye_physiology0.66720375
144* MP0002152_abnormal_brain_morphology0.66094731
145MP0002136_abnormal_kidney_physiology0.65726368
146MP0000534_abnormal_ureter_morphology0.65636309
147MP0002184_abnormal_innervation0.64489786
148MP0004185_abnormal_adipocyte_glucose0.64211825
149MP0005448_abnormal_energy_balance0.63908821
150MP0002736_abnormal_nociception_after0.63822044
151MP0001340_abnormal_eyelid_morphology0.63810885
152MP0001348_abnormal_lacrimal_gland0.62918032
153MP0000003_abnormal_adipose_tissue0.59606138
154MP0002133_abnormal_respiratory_system0.58995382
155MP0005388_respiratory_system_phenotype0.58995382
156MP0002118_abnormal_lipid_homeostasis0.58684899
157MP0005381_digestive/alimentary_phenotyp0.56573517
158MP0009384_cardiac_valve_regurgitation0.55823028
159MP0002735_abnormal_chemical_nociception0.55549104

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.60298185
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.60298185
3Neurofibrillary tangles (HP:0002185)6.10760875
4Parakeratosis (HP:0001036)5.19417740
5Sensory axonal neuropathy (HP:0003390)5.06944685
6Abnormality of the corticospinal tract (HP:0002492)4.90281846
7Peripheral hypomyelination (HP:0007182)4.64840023
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.60760323
9Cerebral inclusion bodies (HP:0100314)4.37252656
10Insidious onset (HP:0003587)4.08093200
11Termporal pattern (HP:0011008)4.08093200
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.06202776
13Focal segmental glomerulosclerosis (HP:0000097)4.06151732
14Onion bulb formation (HP:0003383)4.00448650
15Abnormality of proline metabolism (HP:0010907)3.81236174
16Hydroxyprolinuria (HP:0003080)3.81236174
17Hypobetalipoproteinemia (HP:0003563)3.74020429
18Gout (HP:0001997)3.73056197
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.68130209
20Xanthomatosis (HP:0000991)3.65024786
21Cerebral hypomyelination (HP:0006808)3.55101789
22Supranuclear gaze palsy (HP:0000605)3.40972278
23Segmental peripheral demyelination/remyelination (HP:0003481)3.40917946
24Spastic gait (HP:0002064)3.39759431
25Increased serum pyruvate (HP:0003542)3.39638756
26Abnormality of glycolysis (HP:0004366)3.39638756
27Congenital ichthyosiform erythroderma (HP:0007431)3.27475149
28Hyperglycinuria (HP:0003108)3.26423408
29Late onset (HP:0003584)3.23439757
30Intention tremor (HP:0002080)3.22657704
31Metabolic alkalosis (HP:0200114)3.20609980
32Glomerulosclerosis (HP:0000096)3.19227460
33Increased circulating renin level (HP:0000848)3.18812618
34Distal upper limb amyotrophy (HP:0007149)3.18124573
35Upper limb amyotrophy (HP:0009129)3.18124573
36Potter facies (HP:0002009)3.17759832
37Facial shape deformation (HP:0011334)3.17759832
38Abnormality of serine family amino acid metabolism (HP:0010894)3.15145534
39Abnormality of glycine metabolism (HP:0010895)3.15145534
40Abnormal auditory evoked potentials (HP:0006958)3.13111618
41Hand muscle atrophy (HP:0009130)3.07629144
42Hypomagnesemia (HP:0002917)3.02452590
43Leukodystrophy (HP:0002415)2.97697291
44Alacrima (HP:0000522)2.93488146
45Akinesia (HP:0002304)2.91266878
46Dysmetria (HP:0001310)2.88547187
47Hypokalemic alkalosis (HP:0001949)2.79905318
48Abnormal pancreas size (HP:0012094)2.78903506
49Hypoplastic pelvis (HP:0008839)2.78439558
50Hyperglycinemia (HP:0002154)2.75788121
51Scanning speech (HP:0002168)2.64545852
52Premature skin wrinkling (HP:0100678)2.64432238
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62065384
54Retinal dysplasia (HP:0007973)2.61585655
55Slow saccadic eye movements (HP:0000514)2.55632533
56Ankle clonus (HP:0011448)2.55304503
57Prolonged partial thromboplastin time (HP:0003645)2.55143603
58Spastic paraparesis (HP:0002313)2.54267837
59Stridor (HP:0010307)2.53213740
60Cerebral hemorrhage (HP:0001342)2.50635515
61Hypercholesterolemia (HP:0003124)2.50493340
62Increased purine levels (HP:0004368)2.50080272
63Hyperuricemia (HP:0002149)2.50080272
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.44370674
65Autoamputation (HP:0001218)2.44106569
66Anteriorly placed anus (HP:0001545)2.43473014
67Malnutrition (HP:0004395)2.41515498
68Myokymia (HP:0002411)2.40050078
69Abnormality of magnesium homeostasis (HP:0004921)2.38258715
70Abnormality of purine metabolism (HP:0004352)2.36225487
71Thickened helices (HP:0000391)2.35713654
72Bicornuate uterus (HP:0000813)2.35628335
73Glycosuria (HP:0003076)2.34996620
74Abnormality of urine glucose concentration (HP:0011016)2.34996620
75Hypolipoproteinemia (HP:0010981)2.34221529
76Hemorrhage of the eye (HP:0011885)2.32468291
77Absent septum pellucidum (HP:0001331)2.30595279
78Partial agenesis of the corpus callosum (HP:0001338)2.30057606
79Clumsiness (HP:0002312)2.26294951
80Nephrolithiasis (HP:0000787)2.24191428
81Decreased lacrimation (HP:0000633)2.23776635
82Proximal tubulopathy (HP:0000114)2.22268419
83Foot dorsiflexor weakness (HP:0009027)2.19659143
84Hypercalciuria (HP:0002150)2.19276376
85Action tremor (HP:0002345)2.18353954
86Ulnar claw (HP:0001178)2.17315642
87Pheochromocytoma (HP:0002666)2.13905004
88Vaginal fistula (HP:0004320)2.13762621
89Pigmentary retinal degeneration (HP:0001146)2.12680471
90Hepatosplenomegaly (HP:0001433)2.11916451
91Ulnar bowing (HP:0003031)2.11693429
92CNS hypomyelination (HP:0003429)2.10924629
93Morphological abnormality of the inner ear (HP:0011390)2.10350304
94Cupped ear (HP:0000378)2.09852110
95Hypoplasia of the uterus (HP:0000013)2.09312475
96Steppage gait (HP:0003376)2.08714562
97Spastic tetraparesis (HP:0001285)2.07859998
98Abnormality of the vitreous humor (HP:0004327)2.03441794
99Hyperlipoproteinemia (HP:0010980)2.02484965
100Hammertoe (HP:0001765)2.01800190
101Esophageal atresia (HP:0002032)2.01211953
102Confusion (HP:0001289)2.00896497
103Adrenal hypoplasia (HP:0000835)2.00058103
104Deep venous thrombosis (HP:0002625)1.99938028
105Decreased motor nerve conduction velocity (HP:0003431)1.99703683
106Renal Fanconi syndrome (HP:0001994)1.98199528
107Infantile muscular hypotonia (HP:0008947)1.97977796
108Delayed CNS myelination (HP:0002188)1.97571246
109Abnormality of the foot musculature (HP:0001436)1.95959449
110Abnormality of the middle phalanges of the toes (HP:0010183)1.95693949
111Vascular calcification (HP:0004934)1.94141834
112Split foot (HP:0001839)1.94092341
113Patchy hypopigmentation of hair (HP:0011365)1.91564650
114Methylmalonic acidemia (HP:0002912)1.91265074
115Abnormality of nucleobase metabolism (HP:0010932)1.91258714
116Abnormal urine phosphate concentration (HP:0012599)1.90788229
117Synostosis involving the elbow (HP:0003938)1.89606412
118Humeroradial synostosis (HP:0003041)1.89606412
119Lower limb muscle weakness (HP:0007340)1.89284054
120Abnormality of the septum pellucidum (HP:0007375)1.89271116
121Axonal loss (HP:0003447)1.89053511
122Peripheral demyelination (HP:0011096)1.88982178
123Joint hemorrhage (HP:0005261)1.88526362
124Anomalous pulmonary venous return (HP:0010772)1.87905567
125Abnormality of vitamin metabolism (HP:0100508)1.86963939
126Intrahepatic cholestasis (HP:0001406)1.86275193
127Mesangial abnormality (HP:0001966)1.86076893
128Acute necrotizing encephalopathy (HP:0006965)1.85982468
129White forelock (HP:0002211)1.85762492
130Ileus (HP:0002595)1.85711906
131Fat malabsorption (HP:0002630)1.85221548
132Abnormal urine output (HP:0012590)1.84853384
133Coronal craniosynostosis (HP:0004440)1.84528914
134Erythroderma (HP:0001019)1.84089563
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83167796
136Neuroendocrine neoplasm (HP:0100634)1.82487772
137Hypophosphatemic rickets (HP:0004912)1.82363920
138Hypoplasia of the iris (HP:0007676)1.82323252
139Athetosis (HP:0002305)1.81673231
140Morphological abnormality of the pyramidal tract (HP:0002062)1.80677426
141J-shaped sella turcica (HP:0002680)1.80559238
142Abnormality of renal excretion (HP:0011036)1.80448362
143Hypothermia (HP:0002045)1.77983296
144Acute encephalopathy (HP:0006846)1.77711710
145Alkalosis (HP:0001948)1.77487512
146Renal salt wasting (HP:0000127)1.77413660
147Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.77381990
148Megalencephaly (HP:0001355)1.77119375
149Barrel-shaped chest (HP:0001552)1.76246142
150Distal sensory impairment (HP:0002936)1.75469018
151Bronchomalacia (HP:0002780)1.75413515
152Aplasia/hypoplasia of the uterus (HP:0008684)1.75013675
153Clonus (HP:0002169)1.74521325
154Muscle fiber splitting (HP:0003555)1.72183335
155Urinary incontinence (HP:0000020)1.71723588
156Nuclear cataract (HP:0100018)1.71524559
157Widely patent fontanelles and sutures (HP:0004492)1.70217431
158Generalized myoclonic seizures (HP:0002123)1.69885659
159Gowers sign (HP:0003391)1.68937742
160Choanal stenosis (HP:0000452)1.68635190
161Abnormality of the vocal cords (HP:0008777)1.68568832
162Hyperphosphaturia (HP:0003109)1.68275466
163Hypophosphatemia (HP:0002148)1.68127733
1643-Methylglutaconic aciduria (HP:0003535)1.67874315
165Hepatoblastoma (HP:0002884)1.67695884
166Paraparesis (HP:0002385)1.66571881
167Partial duplication of thumb phalanx (HP:0009944)1.65879938
168Sleep apnea (HP:0010535)1.65047301
169Abnormality of renin-angiotensin system (HP:0000847)1.64147881
170Abnormality of the Achilles tendon (HP:0005109)1.63916930
171Bowing of the arm (HP:0006488)1.63278017
172Bowed forearm bones (HP:0003956)1.63278017
173Turricephaly (HP:0000262)1.62878753
174Diaphragmatic weakness (HP:0009113)1.62621895
175Enlarged kidneys (HP:0000105)1.62290589
176Abnormality of carpal bone ossification (HP:0006257)1.62098909
177Rickets (HP:0002748)1.60369780
178Growth hormone excess (HP:0000845)1.59296619
179Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.58993965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.44536171
2OXSR14.77880561
3EPHB13.90618096
4WNK43.32603450
5MST1R3.19655048
6BCR2.83244797
7EPHA22.67923342
8PBK2.64350051
9MAPKAPK52.58398100
10MET2.55113054
11FGFR42.49218826
12LMTK22.44481528
13DAPK22.43720089
14RIPK12.43316064
15PKN12.39270022
16CDK192.31222483
17TNIK2.17686568
18WNK12.06241300
19NTRK31.97757268
20LIMK11.91890737
21PRPF4B1.90361104
22UHMK11.87765742
23MST41.86116068
24ICK1.78326210
25FGFR21.74909880
26CSNK1G31.68765948
27MAP3K101.60940995
28CSNK1A1L1.58731434
29NEK61.54108588
30DYRK1B1.52165342
31NTRK11.50655376
32CLK11.47687428
33TESK21.45654477
34PNCK1.44442338
35FGR1.42845562
36ROCK21.39910388
37CAMK2B1.39863976
38ERN11.31185644
39EPHB21.29620276
40CSNK1G11.29397780
41ACVR1B1.29237849
42PTK21.24818250
43CSNK1G21.22233946
44PRKG21.22200996
45SGK2231.20326639
46SGK4941.20326639
47CAMK2D1.17805346
48MAPK151.15502852
49DAPK31.15278003
50MAP4K21.14794656
51PRKD31.14662935
52PRKCG1.10924957
53MAPKAPK31.10695901
54CASK1.09019237
55PAK61.02755977
56TYRO31.02062670
57PINK11.01382162
58MAP3K40.99094623
59SIK10.97548194
60EPHA40.97049628
61ERBB40.95856350
62PRKCI0.93414697
63PRKCZ0.90980374
64IRAK20.90818719
65CAMK2G0.89067306
66DYRK20.88243574
67WNK30.85129264
68PAK30.84881562
69PRKCQ0.84814706
70BRAF0.80935591
71CDK140.78169177
72MAP2K20.76231130
73CAMK2A0.76187878
74MARK10.76059201
75FGFR10.75756599
76MARK20.75465288
77PLK20.73555839
78CDK50.73239937
79ERBB20.72208104
80MINK10.71661404
81MAP3K90.67602920
82PRKD10.66334000
83DAPK10.66241600
84CDK150.64682828
85IRAK10.64249118
86SIK20.63299667
87TTN0.62541367
88MAP3K20.61356707
89MAP2K60.60275491
90PRKCE0.60023021
91MAPK110.59835416
92CDK180.58862561
93CDK11A0.58812906
94ABL20.58121927
95EEF2K0.57157149
96PDK20.55999624
97PHKG20.55543298
98PHKG10.55543298
99BRSK10.55327503
100PDPK10.55212930
101MAP2K70.55068241
102FYN0.54810673
103RPS6KA50.53775976
104FGFR30.52642800
105PRKAA10.52045284
106GRK50.49342249
107ARAF0.48481377
108AKT20.47456925
109GSK3A0.46641425
110CSNK1D0.45599966
111SGK10.45414975
112PDGFRA0.44782255
113PRKACG0.43810386
114KSR20.43126368
115BMPR1B0.43011548
116FES0.42538521
117CSNK1A10.42297399
118PRKG10.42120277
119PRKCA0.41506354
120CAMKK10.40306976
121PAK40.40065801
122MUSK0.39616069
123ILK0.38023539
124PRKAA20.37960854
125STK160.37908876
126PRKACB0.37577578
127DMPK0.37448931
128PDGFRB0.37410656
129RPS6KA20.36688403
130ADRBK20.36321481
131MKNK10.35736684
132PAK10.35088181
133STK110.34764173
134GRK70.33589643
135NME10.32778090
136MAPK130.31491725
137ITK0.30804394
138CAMK1G0.30168458
139PRKCH0.29724752
140HIPK20.29632157
141PRKACA0.29248703
142BMX0.29182097
143GRK10.28000987
144INSR0.27394598
145ROCK10.26181017
146TRPM70.26137344
147CSK0.25310260
148PTK2B0.22847109
149NTRK20.22070961
150DDR20.21975260
151MAPK70.21568653
152OBSCN0.21139417
153PDK10.20130758

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.90595366
2Steroid biosynthesis_Homo sapiens_hsa001005.12307019
3Fatty acid elongation_Homo sapiens_hsa000624.71620512
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.12651746
5Cyanoamino acid metabolism_Homo sapiens_hsa004603.91742525
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88920574
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.75196820
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69929055
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.64475714
10* Ether lipid metabolism_Homo sapiens_hsa005652.63186282
11Sulfur metabolism_Homo sapiens_hsa009202.56439604
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.56073886
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32687123
14Arginine biosynthesis_Homo sapiens_hsa002202.20669042
15Oxidative phosphorylation_Homo sapiens_hsa001902.13167900
16Protein export_Homo sapiens_hsa030602.07720995
17Butanoate metabolism_Homo sapiens_hsa006502.02051067
18Fructose and mannose metabolism_Homo sapiens_hsa000511.86786194
19Linoleic acid metabolism_Homo sapiens_hsa005911.82330734
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81732851
21Histidine metabolism_Homo sapiens_hsa003401.78402759
22Bile secretion_Homo sapiens_hsa049761.75042659
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.72369357
24Galactose metabolism_Homo sapiens_hsa000521.72027626
25Starch and sucrose metabolism_Homo sapiens_hsa005001.68818415
26Sulfur relay system_Homo sapiens_hsa041221.65795762
27Vitamin B6 metabolism_Homo sapiens_hsa007501.65431526
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61386634
29Axon guidance_Homo sapiens_hsa043601.53138134
30Parkinsons disease_Homo sapiens_hsa050121.51143591
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47979898
32* Sphingolipid metabolism_Homo sapiens_hsa006001.45396663
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44776461
34Alzheimers disease_Homo sapiens_hsa050101.42530239
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.37859634
36Renin-angiotensin system_Homo sapiens_hsa046141.32363710
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.26300220
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22439204
39Phenylalanine metabolism_Homo sapiens_hsa003601.18395882
40Complement and coagulation cascades_Homo sapiens_hsa046101.16929578
41Arginine and proline metabolism_Homo sapiens_hsa003301.15222362
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.08205345
43PPAR signaling pathway_Homo sapiens_hsa033201.05752564
44Fatty acid metabolism_Homo sapiens_hsa012121.05151441
45Serotonergic synapse_Homo sapiens_hsa047261.04929531
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.04187968
47Biosynthesis of amino acids_Homo sapiens_hsa012300.99825333
48Glutathione metabolism_Homo sapiens_hsa004800.99256106
49Collecting duct acid secretion_Homo sapiens_hsa049660.96660557
50Tryptophan metabolism_Homo sapiens_hsa003800.95325214
51Insulin secretion_Homo sapiens_hsa049110.92015050
52Arachidonic acid metabolism_Homo sapiens_hsa005900.91563847
53Tight junction_Homo sapiens_hsa045300.91223327
54Vibrio cholerae infection_Homo sapiens_hsa051100.90841767
55Glutamatergic synapse_Homo sapiens_hsa047240.90638102
56Propanoate metabolism_Homo sapiens_hsa006400.87529876
57Renal cell carcinoma_Homo sapiens_hsa052110.85739234
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85531767
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85524593
60GABAergic synapse_Homo sapiens_hsa047270.85235065
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84474147
62Long-term depression_Homo sapiens_hsa047300.83420089
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83334280
64Mineral absorption_Homo sapiens_hsa049780.79492991
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.78703751
66Peroxisome_Homo sapiens_hsa041460.78081656
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.76710880
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73874008
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.73725008
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72636548
71Huntingtons disease_Homo sapiens_hsa050160.72415242
72Folate biosynthesis_Homo sapiens_hsa007900.72279843
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.71308952
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.70924101
75Carbon metabolism_Homo sapiens_hsa012000.70721522
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68906844
77Thyroid hormone synthesis_Homo sapiens_hsa049180.65962936
78Synaptic vesicle cycle_Homo sapiens_hsa047210.63952686
79Cardiac muscle contraction_Homo sapiens_hsa042600.63676792
80Vitamin digestion and absorption_Homo sapiens_hsa049770.62693582
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61051938
82Nicotine addiction_Homo sapiens_hsa050330.59697281
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58796384
84Morphine addiction_Homo sapiens_hsa050320.57933935
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57925266
86Lysosome_Homo sapiens_hsa041420.56249887
87Pancreatic secretion_Homo sapiens_hsa049720.55898239
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55726679
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54360656
90Endocytosis_Homo sapiens_hsa041440.53511822
91Cocaine addiction_Homo sapiens_hsa050300.53355396
92Ovarian steroidogenesis_Homo sapiens_hsa049130.52984029
93Chemical carcinogenesis_Homo sapiens_hsa052040.51772274
94Rheumatoid arthritis_Homo sapiens_hsa053230.51679707
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.51587680
96* Metabolic pathways_Homo sapiens_hsa011000.51040776
97Ras signaling pathway_Homo sapiens_hsa040140.50333317
98Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49339916
99Pyruvate metabolism_Homo sapiens_hsa006200.49280728
100Gastric acid secretion_Homo sapiens_hsa049710.49081896
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48991979
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.48481586
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48360386
104Fat digestion and absorption_Homo sapiens_hsa049750.46942843
105Nitrogen metabolism_Homo sapiens_hsa009100.45414059
106Other glycan degradation_Homo sapiens_hsa005110.44503296
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.39783890
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39768621
109Amphetamine addiction_Homo sapiens_hsa050310.39578104
110Circadian entrainment_Homo sapiens_hsa047130.38231577
111Retinol metabolism_Homo sapiens_hsa008300.38130146
112N-Glycan biosynthesis_Homo sapiens_hsa005100.38113258
113Cholinergic synapse_Homo sapiens_hsa047250.37630778
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37608623
115ECM-receptor interaction_Homo sapiens_hsa045120.37563890
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37241892
117Hedgehog signaling pathway_Homo sapiens_hsa043400.37200225
118Dopaminergic synapse_Homo sapiens_hsa047280.37090551
119beta-Alanine metabolism_Homo sapiens_hsa004100.36928061
120Salivary secretion_Homo sapiens_hsa049700.36260145
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35943464
122Fatty acid biosynthesis_Homo sapiens_hsa000610.35329254
123Autoimmune thyroid disease_Homo sapiens_hsa053200.34529898
124Maturity onset diabetes of the young_Homo sapiens_hsa049500.32340784
125ErbB signaling pathway_Homo sapiens_hsa040120.32175747
126Phototransduction_Homo sapiens_hsa047440.31357877
127Dorso-ventral axis formation_Homo sapiens_hsa043200.30683465
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29664953
129Phagosome_Homo sapiens_hsa041450.29449190
130Tyrosine metabolism_Homo sapiens_hsa003500.27841970
131Glycerolipid metabolism_Homo sapiens_hsa005610.27630825
132ABC transporters_Homo sapiens_hsa020100.27613100
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27067916
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21125804
135Renin secretion_Homo sapiens_hsa049240.20983968
136Prion diseases_Homo sapiens_hsa050200.20180426
137Fatty acid degradation_Homo sapiens_hsa000710.19780598
138Gap junction_Homo sapiens_hsa045400.19735468
139Choline metabolism in cancer_Homo sapiens_hsa052310.19550030
140Protein digestion and absorption_Homo sapiens_hsa049740.19468684

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