GAGE13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diterpenoid biosynthetic process (GO:0016102)6.44515923
2proteasome assembly (GO:0043248)5.45696303
3formation of translation preinitiation complex (GO:0001731)5.33646090
4terpenoid biosynthetic process (GO:0016114)5.20321599
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.19836593
6oxidative phosphorylation (GO:0006119)5.00969572
7ATP synthesis coupled proton transport (GO:0015986)4.80807525
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.80807525
9ribosomal large subunit biogenesis (GO:0042273)4.53891195
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.42544071
11DNA unwinding involved in DNA replication (GO:0006268)4.42512595
12resolution of meiotic recombination intermediates (GO:0000712)4.36487612
13DNA replication checkpoint (GO:0000076)4.36048799
14rRNA modification (GO:0000154)4.32035368
15gas transport (GO:0015669)4.29265008
16blastocyst development (GO:0001824)4.27604630
17regulation of translational fidelity (GO:0006450)4.23034041
18ribosomal small subunit biogenesis (GO:0042274)4.17091717
19rRNA methylation (GO:0031167)4.12948302
20oxygen transport (GO:0015671)4.11051889
21ribonucleoprotein complex biogenesis (GO:0022613)4.06638602
22respiratory electron transport chain (GO:0022904)4.06005975
23ribosome assembly (GO:0042255)4.05509403
24ribosomal small subunit assembly (GO:0000028)3.96669369
25electron transport chain (GO:0022900)3.96108228
26ribosome biogenesis (GO:0042254)3.95890359
27protein-cofactor linkage (GO:0018065)3.92806103
28viral transcription (GO:0019083)3.86459708
29aerobic respiration (GO:0009060)3.85300042
30tRNA aminoacylation for protein translation (GO:0006418)3.83721743
31translational termination (GO:0006415)3.80093022
32regulation of gene expression by genetic imprinting (GO:0006349)3.79733445
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77348732
34maturation of SSU-rRNA (GO:0030490)3.76043953
35translational initiation (GO:0006413)3.74705760
36transcription from mitochondrial promoter (GO:0006390)3.73331758
37protoporphyrinogen IX metabolic process (GO:0046501)3.72412036
38nuclear pore complex assembly (GO:0051292)3.70776632
39mitotic sister chromatid segregation (GO:0000070)3.69848873
40tRNA aminoacylation (GO:0043039)3.68893024
41amino acid activation (GO:0043038)3.68893024
42synapsis (GO:0007129)3.68125254
43DNA strand elongation involved in DNA replication (GO:0006271)3.63010245
44homocysteine metabolic process (GO:0050667)3.61194208
45DNA strand elongation (GO:0022616)3.60409116
46protoporphyrinogen IX biosynthetic process (GO:0006782)3.55027809
47DNA replication initiation (GO:0006270)3.53338695
48nuclear pore organization (GO:0006999)3.51723295
49pseudouridine synthesis (GO:0001522)3.50282882
50protein targeting to mitochondrion (GO:0006626)3.49307216
51purine nucleobase biosynthetic process (GO:0009113)3.47802352
52meiotic chromosome segregation (GO:0045132)3.43034037
53tricarboxylic acid cycle (GO:0006099)3.42379828
54SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.42342376
55translation (GO:0006412)3.42198668
56translational elongation (GO:0006414)3.39474164
57chaperone-mediated protein transport (GO:0072321)3.37261714
58sister chromatid segregation (GO:0000819)3.36350548
59mitotic nuclear envelope disassembly (GO:0007077)3.35712817
60cellular component biogenesis (GO:0044085)3.35384091
61cotranslational protein targeting to membrane (GO:0006613)3.33883702
62oxaloacetate metabolic process (GO:0006107)3.31032695
63maturation of 5.8S rRNA (GO:0000460)3.30254757
64mitochondrial RNA metabolic process (GO:0000959)3.30155985
65protein targeting to ER (GO:0045047)3.28478323
66response to vitamin A (GO:0033189)3.27752100
67positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27719692
68telomere maintenance via semi-conservative replication (GO:0032201)3.27679979
69ATP biosynthetic process (GO:0006754)3.26784325
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26324638
71protein localization to endoplasmic reticulum (GO:0070972)3.19161444
72rRNA processing (GO:0006364)3.18736623
73proline biosynthetic process (GO:0006561)3.17325697
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.16617925
75positive regulation of ligase activity (GO:0051351)3.16276382
76regulation of mitotic spindle organization (GO:0060236)3.15798469
77nucleobase biosynthetic process (GO:0046112)3.13024675
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.12463351
79establishment of protein localization to mitochondrion (GO:0072655)3.11210755
80mitotic metaphase plate congression (GO:0007080)3.09033323
81cellular respiration (GO:0045333)3.08960625
82purine nucleoside monophosphate biosynthetic process (GO:0009127)3.07766337
83purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.07766337
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07556230
85mitotic recombination (GO:0006312)3.06930279
86CENP-A containing nucleosome assembly (GO:0034080)3.04992861
87rRNA metabolic process (GO:0016072)3.04089680
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.03761080
89anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02146891
90protein localization to mitochondrion (GO:0070585)3.01968846
91chromosome segregation (GO:0007059)3.01900091
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01807042
93nuclear envelope disassembly (GO:0051081)3.00913877
94membrane disassembly (GO:0030397)3.00913877
95cellular protein complex disassembly (GO:0043624)3.00542569
96DNA topological change (GO:0006265)2.98295305
97regulation of RNA export from nucleus (GO:0046831)2.96047433
98viral life cycle (GO:0019058)2.94434945
99regulation of ubiquitin-protein transferase activity (GO:0051438)2.90524636
100telomere maintenance via recombination (GO:0000722)2.90294949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38675131
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15784255
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.95362061
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85192552
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.62949474
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.45132137
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38594487
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16100444
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.13978293
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.02377162
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93219466
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76712988
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.68318280
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68101819
15ZNF263_19887448_ChIP-Seq_K562_Human2.66724045
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63261464
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.59234443
18FOXM1_23109430_ChIP-Seq_U2OS_Human2.58082067
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54331113
20XRN2_22483619_ChIP-Seq_HELA_Human2.41956173
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41474158
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.38114959
23DCP1A_22483619_ChIP-Seq_HELA_Human2.31088297
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17723095
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11731783
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05320179
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03315328
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02722670
29TTF2_22483619_ChIP-Seq_HELA_Human1.98378812
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.96622105
31FOXP3_21729870_ChIP-Seq_TREG_Human1.93929724
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.92641935
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90281023
34GABP_19822575_ChIP-Seq_HepG2_Human1.90229579
35VDR_23849224_ChIP-Seq_CD4+_Human1.86504379
36ELK1_19687146_ChIP-ChIP_HELA_Human1.79733631
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.73945027
38PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72176902
39KDM5A_27292631_Chip-Seq_BREAST_Human1.70045538
40NCOR1_26117541_ChIP-Seq_K562_Human1.67284728
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64945938
42AR_21909140_ChIP-Seq_LNCAP_Human1.62049120
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60822068
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56035198
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54534863
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53317760
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52113125
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51546699
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50850905
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.47841950
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45072732
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45056610
53CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42802684
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.42336287
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.41803527
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39914338
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39705896
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29570692
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24887344
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24745230
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23440172
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21190339
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21040206
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19874541
65FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19743856
66GATA1_19941826_ChIP-Seq_K562_Human1.16651223
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16413375
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15186520
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14807530
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09467932
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07520544
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07378613
73CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07345102
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07021324
75SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06274467
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03475759
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02418638
78CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98835293
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.97211682
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97166092
81CIITA_25753668_ChIP-Seq_RAJI_Human0.95343183
82TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94556473
83TFEB_21752829_ChIP-Seq_HELA_Human0.92849179
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88558347
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87765436
86CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87120781
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86741201
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.83253560
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82557970
90GATA6_21074721_ChIP-Seq_CACO-2_Human0.82485258
91GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82257752
92GATA2_19941826_ChIP-Seq_K562_Human0.80509133
93ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79935473
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78806158
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.78512103
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78102982
97RBPJ_21746931_ChIP-Seq_IB4_Human0.76778556
98ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76633244
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76070535
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75973650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.39128259
2MP0004147_increased_porphyrin_level4.00371635
3MP0003806_abnormal_nucleotide_metabolis3.99617061
4MP0003693_abnormal_embryo_hatching3.79307163
5MP0003111_abnormal_nucleus_morphology3.49035144
6MP0008058_abnormal_DNA_repair3.34392204
7MP0010094_abnormal_chromosome_stability3.23929760
8MP0008995_early_reproductive_senescence3.19919671
9MP0003186_abnormal_redox_activity2.89839433
10MP0003077_abnormal_cell_cycle2.70924879
11MP0008932_abnormal_embryonic_tissue2.61275961
12MP0009697_abnormal_copulation2.53024230
13MP0003718_maternal_effect2.50911664
14MP0006036_abnormal_mitochondrial_physio2.44170017
15MP0003786_premature_aging2.41800118
16MP0008057_abnormal_DNA_replication2.35580026
17MP0005451_abnormal_body_composition2.35533659
18MP0005083_abnormal_biliary_tract2.24217325
19MP0000372_irregular_coat_pigmentation2.13644286
20MP0005408_hypopigmentation1.99445323
21MP0003656_abnormal_erythrocyte_physiolo1.97363996
22MP0006035_abnormal_mitochondrial_morpho1.96813782
23MP0001730_embryonic_growth_arrest1.94378161
24MP0000678_abnormal_parathyroid_gland1.84261087
25MP0005636_abnormal_mineral_homeostasis1.83680701
26MP0000350_abnormal_cell_proliferation1.67804470
27MP0000015_abnormal_ear_pigmentation1.65290935
28MP0008875_abnormal_xenobiotic_pharmacok1.62418136
29MP0001697_abnormal_embryo_size1.61369060
30MP0002132_abnormal_respiratory_system1.59468859
31MP0002210_abnormal_sex_determination1.58548981
32MP0008007_abnormal_cellular_replicative1.52476848
33MP0002080_prenatal_lethality1.51592658
34MP0005670_abnormal_white_adipose1.50539593
35MP0001672_abnormal_embryogenesis/_devel1.47627643
36MP0005380_embryogenesis_phenotype1.47627643
37MP0000358_abnormal_cell_content/1.47474054
38MP0003941_abnormal_skin_development1.47323565
39MP0002095_abnormal_skin_pigmentation1.42647718
40MP0001929_abnormal_gametogenesis1.41248920
41MP0000313_abnormal_cell_death1.40442758
42MP0003984_embryonic_growth_retardation1.37260399
43MP0004145_abnormal_muscle_electrophysio1.36442866
44MP0002088_abnormal_embryonic_growth/wei1.32733236
45MP0008872_abnormal_physiological_respon1.31348758
46MP0001764_abnormal_homeostasis1.29126044
47MP0002086_abnormal_extraembryonic_tissu1.26522093
48MP0001881_abnormal_mammary_gland1.25922197
49MP0003959_abnormal_lean_body1.19990447
50MP0005410_abnormal_fertilization1.16786479
51MP0001545_abnormal_hematopoietic_system1.16109111
52MP0005397_hematopoietic_system_phenotyp1.16109111
53MP0005171_absent_coat_pigmentation1.15882812
54MP0002796_impaired_skin_barrier1.15276594
55MP0001661_extended_life_span1.15269378
56MP0004233_abnormal_muscle_weight1.12961185
57MP0010234_abnormal_vibrissa_follicle1.09965412
58MP0008260_abnormal_autophagy1.07235544
59MP0010030_abnormal_orbit_morphology1.07167465
60MP0000647_abnormal_sebaceous_gland1.06742734
61MP0005058_abnormal_lysosome_morphology1.05406221
62MP0009333_abnormal_splenocyte_physiolog1.04929077
63MP0001145_abnormal_male_reproductive1.04627498
64MP0003698_abnormal_male_reproductive1.04472859
65MP0001502_abnormal_circadian_rhythm1.02679637
66MP0005501_abnormal_skin_physiology1.02147802
67MP0009379_abnormal_foot_pigmentation1.00810864
68MP0000653_abnormal_sex_gland0.99477633
69MP0002085_abnormal_embryonic_tissue0.98119897
70MP0003699_abnormal_female_reproductive0.96306463
71MP0001727_abnormal_embryo_implantation0.95960376
72MP0008775_abnormal_heart_ventricle0.93964684
73MP0005332_abnormal_amino_acid0.91070987
74MP0005266_abnormal_metabolism0.88635857
75MP0005319_abnormal_enzyme/_coenzyme0.83286639
76MP0002019_abnormal_tumor_incidence0.81854704
77MP0002084_abnormal_developmental_patter0.81186609
78MP0004185_abnormal_adipocyte_glucose0.79827930
79MP0004084_abnormal_cardiac_muscle0.78279519
80MP0002161_abnormal_fertility/fecundity0.78126714
81MP0008770_decreased_survivor_rate0.77736140
82MP0006292_abnormal_olfactory_placode0.75581134
83MP0000609_abnormal_liver_physiology0.75423641
84MP0001919_abnormal_reproductive_system0.74967594
85MP0003646_muscle_fatigue0.74377937
86MP0002396_abnormal_hematopoietic_system0.73551021
87MP0006138_congestive_heart_failure0.72606384
88MP0002160_abnormal_reproductive_system0.71475148
89MP0002938_white_spotting0.71250009
90MP0008961_abnormal_basal_metabolism0.69436866
91MP0004019_abnormal_vitamin_homeostasis0.66597000
92MP0005389_reproductive_system_phenotype0.66112419
93MP0003385_abnormal_body_wall0.65392222
94MP0005330_cardiomyopathy0.64158974
95MP0002269_muscular_atrophy0.63749747
96MP0000371_diluted_coat_color0.62675825
97MP0009931_abnormal_skin_appearance0.61503136
98MP0009765_abnormal_xenobiotic_induced0.61404698
99MP0003936_abnormal_reproductive_system0.61001166
100MP0004264_abnormal_extraembryonic_tissu0.60883703

Predicted human phenotypes

RankGene SetZ-score
1Abnormal gallbladder physiology (HP:0012438)5.08957965
2Cholecystitis (HP:0001082)5.08957965
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.78570653
4Reticulocytosis (HP:0001923)4.36253588
5Truncus arteriosus (HP:0001660)4.34020842
6Abnormal hemoglobin (HP:0011902)4.33393900
7Acute necrotizing encephalopathy (HP:0006965)4.33356127
8Hyperthyroidism (HP:0000836)4.21162529
9Abnormality of reticulocytes (HP:0004312)4.16817335
10Acute encephalopathy (HP:0006846)4.13500536
11Abnormal mitochondria in muscle tissue (HP:0008316)4.09055424
12Cerebral hypomyelination (HP:0006808)3.86173119
13Reticulocytopenia (HP:0001896)3.75785244
14Seborrheic dermatitis (HP:0001051)3.72194231
15Pallor (HP:0000980)3.68523865
16Ileus (HP:0002595)3.62781739
17Birth length less than 3rd percentile (HP:0003561)3.60047473
18Progressive macrocephaly (HP:0004481)3.46207077
19Increased CSF lactate (HP:0002490)3.45419824
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.29996905
21Chromsome breakage (HP:0040012)3.17018630
22Mitochondrial inheritance (HP:0001427)3.16650057
23Abnormality of glycolysis (HP:0004366)3.04627546
24Hypertensive crisis (HP:0100735)3.04203937
25Increased serum pyruvate (HP:0003542)3.02461661
26Abnormality of alanine metabolism (HP:0010916)3.00643447
27Hyperalaninemia (HP:0003348)3.00643447
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00643447
29Abnormality of cells of the erythroid lineage (HP:0012130)3.00633755
30Abnormality of the tricuspid valve (HP:0001702)2.97237450
31Cerebral edema (HP:0002181)2.93630483
32Duplicated collecting system (HP:0000081)2.93506152
33Abnormal number of erythroid precursors (HP:0012131)2.92176649
34CNS hypomyelination (HP:0003429)2.88931850
35Increased serum lactate (HP:0002151)2.86380937
36Pheochromocytoma (HP:0002666)2.81583006
37Neuroendocrine neoplasm (HP:0100634)2.79389829
38Homocystinuria (HP:0002156)2.78374898
39Abnormality of homocysteine metabolism (HP:0010919)2.78374898
40Tinnitus (HP:0000360)2.76506209
41Polycythemia (HP:0001901)2.74506884
42Hypoparathyroidism (HP:0000829)2.72907658
43Cholelithiasis (HP:0001081)2.64889631
44Lactic acidosis (HP:0003128)2.63956362
45Renal Fanconi syndrome (HP:0001994)2.61997057
46Hepatocellular necrosis (HP:0001404)2.57490889
47Upper limb muscle weakness (HP:0003484)2.53292521
48Palpitations (HP:0001962)2.52643135
49Increased hepatocellular lipid droplets (HP:0006565)2.51160009
50Abnormality of the renal collecting system (HP:0004742)2.51095203
51Respiratory difficulties (HP:0002880)2.50102487
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.48535779
53Macrocytic anemia (HP:0001972)2.47997672
54Redundant skin (HP:0001582)2.46122495
55Bowel incontinence (HP:0002607)2.44179138
56Conjunctival hamartoma (HP:0100780)2.43524448
57Abnormal large intestine physiology (HP:0012700)2.40251687
58Abnormality of cochlea (HP:0000375)2.36087424
59Poikilocytosis (HP:0004447)2.33098947
60Paralysis (HP:0003470)2.32866941
61Neoplasm of head and neck (HP:0012288)2.32539863
62Esophageal neoplasm (HP:0100751)2.32539863
63Hepatic necrosis (HP:0002605)2.31859672
64Cortical dysplasia (HP:0002539)2.30534551
65Abnormal gallbladder morphology (HP:0012437)2.30499645
66Leukodystrophy (HP:0002415)2.29725584
67Cerebral hemorrhage (HP:0001342)2.29254001
68Adenoma sebaceum (HP:0009720)2.28991067
69Angiofibromas (HP:0010615)2.28991067
70Spastic paraparesis (HP:0002313)2.28490800
71Premature ovarian failure (HP:0008209)2.26780707
72Atelectasis (HP:0100750)2.22749800
73Hyperbilirubinemia (HP:0002904)2.21235254
74Lipid accumulation in hepatocytes (HP:0006561)2.20166261
75Respiratory failure (HP:0002878)2.19769612
76Abnormality of methionine metabolism (HP:0010901)2.18775927
77Ankyloglossia (HP:0010296)2.18503184
78Breast hypoplasia (HP:0003187)2.17755606
79Delusions (HP:0000746)2.16793758
80Increased intramyocellular lipid droplets (HP:0012240)2.09925912
81Ureteral duplication (HP:0000073)2.09348979
82Short middle phalanx of the 5th finger (HP:0004220)2.07406067
83Abnormality of the preputium (HP:0100587)2.05797076
84CNS demyelination (HP:0007305)2.04816456
85Abnormality of DNA repair (HP:0003254)2.02816515
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02662114
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02662114
88Exercise intolerance (HP:0003546)2.00438640
89Septate vagina (HP:0001153)1.98974233
90Breech presentation (HP:0001623)1.98526931
91Neoplasm of the peripheral nervous system (HP:0100007)1.98110564
92Concave nail (HP:0001598)1.96149184
93Secondary amenorrhea (HP:0000869)1.95429110
94Hypoplasia of the fovea (HP:0007750)1.94714261
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.94714261
96Morphological abnormality of the inner ear (HP:0011390)1.93134051
97Lethargy (HP:0001254)1.90382377
98Abnormality of the fovea (HP:0000493)1.89472320
99Hepatocellular carcinoma (HP:0001402)1.88887050
100Patellar dislocation (HP:0002999)1.85156907

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.63043606
2EIF2AK14.67350992
3PDK24.38500944
4NEK13.92964178
5MST43.33568180
6NME23.06684161
7WNK42.67531942
8TTK2.57320249
9BUB12.45673502
10SRPK12.35169353
11NME12.25358597
12CCNB12.10357916
13CLK12.09721571
14KSR22.07374142
15EIF2AK32.03643938
16RIPK41.93222609
17CDC71.85557476
18TSSK61.82784626
19STK161.65094839
20BRSK21.63265920
21IRAK31.58447679
22BRSK11.50406815
23EEF2K1.43642106
24WEE11.42228437
25KSR11.39991245
26RAF11.39152921
27CHEK21.36777842
28PLK41.31215722
29NTRK31.29372845
30STK41.27510038
31MAP3K81.26168526
32PLK31.26123666
33MAP3K21.25284730
34BMX1.23585025
35NEK21.21322107
36BMPR21.18803286
37RPS6KB21.16701490
38TRIM281.16142691
39MST1R1.05123696
40ALK1.00641071
41MAPKAPK30.96273683
42VRK20.96099695
43ILK0.93930906
44SIK30.92738863
45PLK10.87048988
46CHEK10.81119355
47ICK0.79924112
48STK390.77079967
49BRAF0.76834560
50NTRK10.75508962
51ATR0.74854257
52MKNK10.72596984
53JAK30.71243486
54EIF2AK20.70575544
55MARK30.67198813
56SCYL20.66420967
57STK30.64657047
58CDK70.61132685
59DMPK0.60575813
60AURKB0.59728809
61CSNK2A20.58876579
62PAK10.57933353
63STK100.56503441
64TRPM70.53732645
65CDK10.53558836
66MAP3K10.51626624
67MET0.48819106
68ATM0.48012296
69CSNK2A10.47719352
70MATK0.47065208
71CDK20.46779065
72LRRK20.45899169
73MAP3K120.44890371
74CDK80.43982139
75MAP2K10.42245383
76PRKCI0.41686782
77ZAK0.40923891
78NUAK10.40249881
79PRKG20.40101203
80CSNK1E0.39835181
81MAPKAPK50.39624983
82AURKA0.37955740
83WNK10.33778310
84RPS6KA50.30491189
85PASK0.29870314
86PAK40.28910117
87MKNK20.27799639
88JAK20.25848086
89PIM10.24377244
90NEK60.22291276
91MAPKAPK20.19786105
92PIK3CG0.19323668
93PHKG20.18868299
94PHKG10.18868299
95BCR0.18286412
96CDK180.17339226
97CDK11A0.16819525
98OXSR10.16188581
99AKT20.15645171
100AKT30.15564633

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.17361713
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.45888815
3Proteasome_Homo sapiens_hsa030503.41486524
4Oxidative phosphorylation_Homo sapiens_hsa001903.41382980
5Parkinsons disease_Homo sapiens_hsa050123.38813330
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.25832177
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23582645
8DNA replication_Homo sapiens_hsa030303.17577559
9Homologous recombination_Homo sapiens_hsa034402.98994839
10Mismatch repair_Homo sapiens_hsa034302.79682933
11Huntingtons disease_Homo sapiens_hsa050162.58206541
12One carbon pool by folate_Homo sapiens_hsa006702.55291511
13RNA polymerase_Homo sapiens_hsa030202.54395720
14RNA transport_Homo sapiens_hsa030132.29642459
15Basal transcription factors_Homo sapiens_hsa030222.10513654
16Spliceosome_Homo sapiens_hsa030402.07812936
17Alzheimers disease_Homo sapiens_hsa050102.07672204
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.07506847
19Fanconi anemia pathway_Homo sapiens_hsa034601.89798062
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.89065126
21Nucleotide excision repair_Homo sapiens_hsa034201.86180598
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78996518
23Pyruvate metabolism_Homo sapiens_hsa006201.65811799
24Pyrimidine metabolism_Homo sapiens_hsa002401.58161071
25Carbon metabolism_Homo sapiens_hsa012001.57881552
26Base excision repair_Homo sapiens_hsa034101.56369767
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.51179429
28Cell cycle_Homo sapiens_hsa041101.49333387
29Biosynthesis of amino acids_Homo sapiens_hsa012301.40372565
30Cardiac muscle contraction_Homo sapiens_hsa042601.37934772
31Non-homologous end-joining_Homo sapiens_hsa034501.32333986
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.20490232
33Selenocompound metabolism_Homo sapiens_hsa004501.16501597
34mRNA surveillance pathway_Homo sapiens_hsa030151.15708963
35RNA degradation_Homo sapiens_hsa030181.15320188
36Steroid biosynthesis_Homo sapiens_hsa001001.13011205
37Purine metabolism_Homo sapiens_hsa002301.08007225
38Fructose and mannose metabolism_Homo sapiens_hsa000511.03874481
39Protein export_Homo sapiens_hsa030601.03858080
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97263069
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94836035
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93690192
43Folate biosynthesis_Homo sapiens_hsa007900.91681013
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89821429
45Pentose phosphate pathway_Homo sapiens_hsa000300.86882023
46Sulfur relay system_Homo sapiens_hsa041220.85525788
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.84562734
48N-Glycan biosynthesis_Homo sapiens_hsa005100.83261084
49Arginine biosynthesis_Homo sapiens_hsa002200.80960664
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80504719
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77079461
52Metabolic pathways_Homo sapiens_hsa011000.76066571
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70523690
54Sulfur metabolism_Homo sapiens_hsa009200.68892562
55Fatty acid elongation_Homo sapiens_hsa000620.64356392
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62674262
57Tyrosine metabolism_Homo sapiens_hsa003500.62637457
58Oocyte meiosis_Homo sapiens_hsa041140.58877718
59Propanoate metabolism_Homo sapiens_hsa006400.58719911
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50379394
61Glutathione metabolism_Homo sapiens_hsa004800.49655686
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.47946634
63Epstein-Barr virus infection_Homo sapiens_hsa051690.47255818
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47040124
65HIF-1 signaling pathway_Homo sapiens_hsa040660.46043267
66Thyroid cancer_Homo sapiens_hsa052160.38054299
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37720349
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37059882
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35530173
70Galactose metabolism_Homo sapiens_hsa000520.34579433
71p53 signaling pathway_Homo sapiens_hsa041150.33935754
72Retinol metabolism_Homo sapiens_hsa008300.30807791
73Acute myeloid leukemia_Homo sapiens_hsa052210.28800609
74Fatty acid metabolism_Homo sapiens_hsa012120.28444065
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25809932
76Olfactory transduction_Homo sapiens_hsa047400.25368108
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.24494234
78Arginine and proline metabolism_Homo sapiens_hsa003300.24423873
79Viral carcinogenesis_Homo sapiens_hsa052030.23109260
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21766929
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21140460
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.17250894
83Regulation of autophagy_Homo sapiens_hsa041400.16808673
84Chronic myeloid leukemia_Homo sapiens_hsa052200.14109935
85Nitrogen metabolism_Homo sapiens_hsa009100.13369221
86ABC transporters_Homo sapiens_hsa020100.11042743
87Phenylalanine metabolism_Homo sapiens_hsa003600.10111233
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.09628975
89Pancreatic cancer_Homo sapiens_hsa052120.09331029
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.09014867
91Apoptosis_Homo sapiens_hsa042100.08149532
92Collecting duct acid secretion_Homo sapiens_hsa049660.08042005
93Vitamin B6 metabolism_Homo sapiens_hsa007500.07404464
94Insulin signaling pathway_Homo sapiens_hsa049100.06614790
95Prion diseases_Homo sapiens_hsa050200.05757751
96mTOR signaling pathway_Homo sapiens_hsa041500.05694173
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05560038
98Shigellosis_Homo sapiens_hsa051310.03528459
99Peroxisome_Homo sapiens_hsa041460.03438150
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.03352373

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