GAGE12F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.61398916
2proteasome assembly (GO:0043248)5.16073786
3nuclear pore organization (GO:0006999)5.06759924
4formation of translation preinitiation complex (GO:0001731)4.98045976
5DNA replication checkpoint (GO:0000076)4.92229183
6diterpenoid biosynthetic process (GO:0016102)4.72432347
7regulation of translational fidelity (GO:0006450)4.67251090
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.56593959
9gas transport (GO:0015669)4.46368412
10terpenoid biosynthetic process (GO:0016114)4.40505984
11oxidative phosphorylation (GO:0006119)4.32445738
12oxygen transport (GO:0015671)4.23585963
13DNA replication initiation (GO:0006270)4.22644508
14synapsis (GO:0007129)4.20256270
15pore complex assembly (GO:0046931)4.17241664
16mitotic nuclear envelope disassembly (GO:0007077)4.15687908
17resolution of meiotic recombination intermediates (GO:0000712)4.13967606
18tRNA aminoacylation for protein translation (GO:0006418)4.13761485
19ribosome assembly (GO:0042255)4.06093349
20amino acid activation (GO:0043038)4.00679570
21tRNA aminoacylation (GO:0043039)4.00679570
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95839779
23ATP synthesis coupled proton transport (GO:0015986)3.95839779
24protoporphyrinogen IX metabolic process (GO:0046501)3.93183294
25DNA strand elongation involved in DNA replication (GO:0006271)3.91577423
26rRNA methylation (GO:0031167)3.83077070
27DNA strand elongation (GO:0022616)3.81381693
28rRNA modification (GO:0000154)3.80982387
29purine nucleobase biosynthetic process (GO:0009113)3.80777487
30membrane disassembly (GO:0030397)3.77311603
31nuclear envelope disassembly (GO:0051081)3.77311603
32protoporphyrinogen IX biosynthetic process (GO:0006782)3.69136199
33maturation of 5.8S rRNA (GO:0000460)3.68954868
34DNA unwinding involved in DNA replication (GO:0006268)3.64987808
35telomere maintenance via semi-conservative replication (GO:0032201)3.61687282
36mitotic sister chromatid segregation (GO:0000070)3.61099109
37regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60904890
38ribosome biogenesis (GO:0042254)3.60372751
39ribosomal large subunit biogenesis (GO:0042273)3.56648689
40nucleobase biosynthetic process (GO:0046112)3.52479880
41regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50861473
42nucleobase-containing small molecule interconversion (GO:0015949)3.47776480
43respiratory electron transport chain (GO:0022904)3.46483888
44mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39329216
45IMP biosynthetic process (GO:0006188)3.37460031
46electron transport chain (GO:0022900)3.37365237
47aerobic respiration (GO:0009060)3.35782567
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.35279808
49ribonucleoprotein complex biogenesis (GO:0022613)3.34529053
50sister chromatid segregation (GO:0000819)3.30246696
51mitotic metaphase plate congression (GO:0007080)3.29352686
52pseudouridine synthesis (GO:0001522)3.26449885
53protein targeting to mitochondrion (GO:0006626)3.25524344
54deoxyribonucleotide biosynthetic process (GO:0009263)3.23782176
55positive regulation of ligase activity (GO:0051351)3.21109664
56folic acid-containing compound biosynthetic process (GO:0009396)3.19688246
57negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.17649275
58mitotic recombination (GO:0006312)3.17524008
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17321259
60telomere maintenance via recombination (GO:0000722)3.14011377
61oxaloacetate metabolic process (GO:0006107)3.11105384
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09517330
63regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09390791
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09216852
65homocysteine metabolic process (GO:0050667)3.09040763
66regulation of translational elongation (GO:0006448)3.05382651
67chromosome segregation (GO:0007059)3.02944930
68regulation of ubiquitin-protein transferase activity (GO:0051438)3.00627720
69heme biosynthetic process (GO:0006783)3.00024744
70DNA topological change (GO:0006265)2.99407921
71regulation of mitotic spindle organization (GO:0060236)2.99089362
72cellular respiration (GO:0045333)2.98096768
73mitochondrial RNA metabolic process (GO:0000959)2.97181420
74negative regulation of ligase activity (GO:0051352)2.92861338
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92861338
76meiotic chromosome segregation (GO:0045132)2.90988592
77regulation of ligase activity (GO:0051340)2.90195732
78regulation of RNA export from nucleus (GO:0046831)2.90184218
79negative regulation of smooth muscle cell differentiation (GO:0051151)2.89615242
80rRNA processing (GO:0006364)2.88392629
81transcription from mitochondrial promoter (GO:0006390)2.88375611
82IMP metabolic process (GO:0046040)2.88275623
83negative regulation of protein acetylation (GO:1901984)2.87774594
84nuclear envelope organization (GO:0006998)2.87512495
85establishment of protein localization to mitochondrion (GO:0072655)2.87504037
86protein-cofactor linkage (GO:0018065)2.86974352
87protein localization to mitochondrion (GO:0070585)2.86700024
88regulation of histone H3-K4 methylation (GO:0051569)2.85861737
89regulation of cellular amino acid metabolic process (GO:0006521)2.84622595
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.83964938
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.83964938
92maturation of SSU-rRNA (GO:0030490)2.83848368
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83714026
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.83166608
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.83166608
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.83166608
97purine nucleoside monophosphate biosynthetic process (GO:0009127)2.81980800
98purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.81980800
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81044806
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.81044806

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.72559868
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.46409800
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.71070755
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59475989
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.52976324
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.36729596
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31084855
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.27473705
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19224731
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.16818921
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.05425403
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.02175642
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84798031
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77040610
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71956253
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.63573367
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59307554
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.45538192
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39820620
20DCP1A_22483619_ChIP-Seq_HELA_Human2.33469414
21XRN2_22483619_ChIP-Seq_HELA_Human2.24830466
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21699785
23ELK1_19687146_ChIP-ChIP_HELA_Human2.19407196
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12727626
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.05889259
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04224381
27AR_21909140_ChIP-Seq_LNCAP_Human2.02936182
28VDR_23849224_ChIP-Seq_CD4+_Human2.00312469
29FOXP3_21729870_ChIP-Seq_TREG_Human1.98365967
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.98081090
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94529402
32TTF2_22483619_ChIP-Seq_HELA_Human1.92304535
33GABP_19822575_ChIP-Seq_HepG2_Human1.88711026
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82686647
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81453890
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80491760
37ZNF263_19887448_ChIP-Seq_K562_Human1.80014051
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77032380
39NCOR1_26117541_ChIP-Seq_K562_Human1.76488773
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.76167410
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.74529948
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72260848
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71514383
44KDM5A_27292631_Chip-Seq_BREAST_Human1.69258242
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.66798011
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65811055
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65423033
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65394138
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61703110
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.56226208
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54537058
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53445576
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53272568
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47578483
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44332058
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.42415743
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33899942
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32775242
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30971627
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29353446
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26089217
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25420040
63TFEB_21752829_ChIP-Seq_HELA_Human1.24251351
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23833624
65BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21927779
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16161256
67CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14736090
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13355821
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12823970
70CIITA_25753668_ChIP-Seq_RAJI_Human1.10780134
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07995400
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07077419
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06976811
74GATA1_19941826_ChIP-Seq_K562_Human1.06132067
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04494756
76CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04248087
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01055603
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98858824
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98767992
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.98274961
81CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97517781
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97043737
83MYC_18940864_ChIP-ChIP_HL60_Human0.94878780
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93514057
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.93373959
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90415454
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90207396
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90151607
89GATA2_19941826_ChIP-Seq_K562_Human0.89867733
90RBPJ_21746931_ChIP-Seq_IB4_Human0.88754818
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87565614
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87541960
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86218777
94E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86128813
95PHF8_20622853_ChIP-Seq_HELA_Human0.84554941
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83735170
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83683019
98CHD1_26751641_Chip-Seq_LNCaP_Human0.80988278
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.79500696
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77279478

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.18024491
2MP0004957_abnormal_blastocyst_morpholog4.03972102
3MP0008058_abnormal_DNA_repair3.76720146
4MP0003806_abnormal_nucleotide_metabolis3.74126036
5MP0003111_abnormal_nucleus_morphology3.70741728
6MP0010094_abnormal_chromosome_stability3.53222749
7MP0008995_early_reproductive_senescence3.38041601
8MP0003693_abnormal_embryo_hatching3.37777393
9MP0005451_abnormal_body_composition3.20888064
10MP0000372_irregular_coat_pigmentation2.95575384
11MP0003186_abnormal_redox_activity2.83994777
12MP0003786_premature_aging2.83726428
13MP0009697_abnormal_copulation2.83557826
14MP0003077_abnormal_cell_cycle2.72954303
15MP0005171_absent_coat_pigmentation2.62876461
16MP0008932_abnormal_embryonic_tissue2.58097513
17MP0004084_abnormal_cardiac_muscle2.40620903
18MP0005408_hypopigmentation2.38978384
19MP0006036_abnormal_mitochondrial_physio2.36868892
20MP0003718_maternal_effect2.36440647
21MP0008057_abnormal_DNA_replication2.21190082
22MP0008007_abnormal_cellular_replicative2.08130925
23MP0006035_abnormal_mitochondrial_morpho2.05625950
24MP0002132_abnormal_respiratory_system1.96611212
25MP0001881_abnormal_mammary_gland1.94459276
26MP0000678_abnormal_parathyroid_gland1.84952571
27MP0008775_abnormal_heart_ventricle1.70904839
28MP0005083_abnormal_biliary_tract1.65783941
29MP0001730_embryonic_growth_arrest1.57953585
30MP0000350_abnormal_cell_proliferation1.55674168
31MP0001697_abnormal_embryo_size1.52850210
32MP0000358_abnormal_cell_content/1.50907237
33MP0004036_abnormal_muscle_relaxation1.48932590
34MP0002210_abnormal_sex_determination1.48335473
35MP0001764_abnormal_homeostasis1.48135576
36MP0003656_abnormal_erythrocyte_physiolo1.46073450
37MP0001929_abnormal_gametogenesis1.44788362
38MP0000313_abnormal_cell_death1.39719429
39MP0002080_prenatal_lethality1.35040625
40MP0005636_abnormal_mineral_homeostasis1.33182926
41MP0001545_abnormal_hematopoietic_system1.32395781
42MP0005397_hematopoietic_system_phenotyp1.32395781
43MP0003959_abnormal_lean_body1.29839179
44MP0001661_extended_life_span1.28555558
45MP0005380_embryogenesis_phenotype1.26423727
46MP0001672_abnormal_embryogenesis/_devel1.26423727
47MP0004484_altered_response_of1.24767167
48MP0005410_abnormal_fertilization1.16936159
49MP0003984_embryonic_growth_retardation1.15484455
50MP0002088_abnormal_embryonic_growth/wei1.11727535
51MP0004233_abnormal_muscle_weight1.10887294
52MP0002086_abnormal_extraembryonic_tissu1.06253805
53MP0003698_abnormal_male_reproductive1.03540234
54MP0001145_abnormal_male_reproductive1.02581673
55MP0002095_abnormal_skin_pigmentation1.00392072
56MP0000653_abnormal_sex_gland0.99510189
57MP0005330_cardiomyopathy0.98182516
58MP0006138_congestive_heart_failure0.97684739
59MP0008961_abnormal_basal_metabolism0.94289223
60MP0004145_abnormal_muscle_electrophysio0.93283509
61MP0010307_abnormal_tumor_latency0.90343355
62MP0003646_muscle_fatigue0.89815482
63MP0009333_abnormal_splenocyte_physiolog0.85296026
64MP0001727_abnormal_embryo_implantation0.84611057
65MP0002396_abnormal_hematopoietic_system0.83465017
66MP0000015_abnormal_ear_pigmentation0.83214840
67MP0002161_abnormal_fertility/fecundity0.79390488
68MP0002085_abnormal_embryonic_tissue0.79317624
69MP0002019_abnormal_tumor_incidence0.79206598
70MP0003699_abnormal_female_reproductive0.77916174
71MP0005266_abnormal_metabolism0.76901766
72MP0008875_abnormal_xenobiotic_pharmacok0.76177353
73MP0005332_abnormal_amino_acid0.75706405
74MP0001502_abnormal_circadian_rhythm0.75702249
75MP0008770_decreased_survivor_rate0.73996599
76MP0003936_abnormal_reproductive_system0.73721608
77MP0002084_abnormal_developmental_patter0.71924826
78MP0008438_abnormal_cutaneous_collagen0.71593103
79MP0001119_abnormal_female_reproductive0.70285271
80MP0001919_abnormal_reproductive_system0.70126565
81MP0004272_abnormal_basement_membrane0.70038519
82MP0002160_abnormal_reproductive_system0.69195396
83MP0000609_abnormal_liver_physiology0.67996084
84MP0000647_abnormal_sebaceous_gland0.67707972
85MP0008260_abnormal_autophagy0.66512803
86MP0002938_white_spotting0.64958353
87MP0003828_pulmonary_edema0.64024859
88MP0001915_intracranial_hemorrhage0.63784699
89MP0005389_reproductive_system_phenotype0.62880362
90MP0005384_cellular_phenotype0.62573152
91MP0000598_abnormal_liver_morphology0.62429228
92MP0005360_urolithiasis0.62359248
93MP0002269_muscular_atrophy0.61364643
94MP0000747_muscle_weakness0.61118680
95MP0003136_yellow_coat_color0.60951161
96MP0005376_homeostasis/metabolism_phenot0.60663902
97MP0005395_other_phenotype0.60590854
98MP0005075_abnormal_melanosome_morpholog0.59190506
99MP0005058_abnormal_lysosome_morphology0.58763292
100MP0004381_abnormal_hair_follicle0.58373823

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)5.95271176
2Abnormal gallbladder physiology (HP:0012438)5.95271176
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.83807104
4Abnormal hemoglobin (HP:0011902)4.37302437
5Truncus arteriosus (HP:0001660)4.35682197
6Hyperthyroidism (HP:0000836)4.11483168
7Reticulocytosis (HP:0001923)4.10816967
8Acute encephalopathy (HP:0006846)4.03891463
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.03645168
10Birth length less than 3rd percentile (HP:0003561)3.98505186
11Chromsome breakage (HP:0040012)3.91975188
12Acute necrotizing encephalopathy (HP:0006965)3.91132562
13Abnormality of reticulocytes (HP:0004312)3.83480559
14Cerebral hypomyelination (HP:0006808)3.72418559
15Abnormal mitochondria in muscle tissue (HP:0008316)3.67024964
16Abnormality of glycolysis (HP:0004366)3.65118679
17Ileus (HP:0002595)3.63736490
18Upper limb muscle weakness (HP:0003484)3.42244370
19Increased serum pyruvate (HP:0003542)3.35156246
20Increased CSF lactate (HP:0002490)3.30713437
21Seborrheic dermatitis (HP:0001051)3.26362979
22Reticulocytopenia (HP:0001896)3.25770363
23Progressive macrocephaly (HP:0004481)3.17341412
24Hypertensive crisis (HP:0100735)3.15834121
25Pallor (HP:0000980)3.14996137
26Mitochondrial inheritance (HP:0001427)3.04369970
27Abnormality of the preputium (HP:0100587)2.99022566
28Abnormality of the tricuspid valve (HP:0001702)2.98060321
29Polycythemia (HP:0001901)2.92238746
30Hepatocellular necrosis (HP:0001404)2.82170838
31Cholelithiasis (HP:0001081)2.79116714
32Duplicated collecting system (HP:0000081)2.75282078
33Spastic paraparesis (HP:0002313)2.70274446
34Hypoparathyroidism (HP:0000829)2.69938175
35Tinnitus (HP:0000360)2.68183810
36Cerebral edema (HP:0002181)2.66783908
37Homocystinuria (HP:0002156)2.65154887
38Abnormality of homocysteine metabolism (HP:0010919)2.65154887
39Increased hepatocellular lipid droplets (HP:0006565)2.62446038
40CNS hypomyelination (HP:0003429)2.61869293
41Increased serum lactate (HP:0002151)2.57609065
42Short middle phalanx of the 5th finger (HP:0004220)2.52643001
43Abnormal large intestine physiology (HP:0012700)2.52482322
44Bowel incontinence (HP:0002607)2.51923438
45Abnormality of cochlea (HP:0000375)2.46402329
46Hepatic necrosis (HP:0002605)2.46177605
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.45340854
48Poikilocytosis (HP:0004447)2.43097046
49Abnormal gallbladder morphology (HP:0012437)2.42213013
50Abnormality of the renal collecting system (HP:0004742)2.41578058
51Renal Fanconi syndrome (HP:0001994)2.39563891
52Lipid accumulation in hepatocytes (HP:0006561)2.37446077
53Ureteral duplication (HP:0000073)2.36972291
54Lactic acidosis (HP:0003128)2.32706556
55Ankyloglossia (HP:0010296)2.30465925
56Respiratory difficulties (HP:0002880)2.30209000
57Morphological abnormality of the inner ear (HP:0011390)2.25579024
58Meckel diverticulum (HP:0002245)2.22318410
59Cortical dysplasia (HP:0002539)2.21191476
60Myelodysplasia (HP:0002863)2.19700738
61Abnormality of chromosome stability (HP:0003220)2.19480815
62Abnormality of DNA repair (HP:0003254)2.19223780
63Atelectasis (HP:0100750)2.18519686
64Microvesicular hepatic steatosis (HP:0001414)2.17304842
65Pheochromocytoma (HP:0002666)2.16755211
66Small intestinal stenosis (HP:0012848)2.15207994
67Duodenal stenosis (HP:0100867)2.15207994
68Premature ovarian failure (HP:0008209)2.14554587
69Secondary amenorrhea (HP:0000869)2.12028024
70Respiratory failure (HP:0002878)2.10771723
71Redundant skin (HP:0001582)2.08800845
72Neuroendocrine neoplasm (HP:0100634)2.08617955
73Abnormality of the ileum (HP:0001549)2.07605781
74Aplasia/Hypoplasia of the earlobes (HP:0009906)2.04542525
75Leukodystrophy (HP:0002415)2.04220644
76Abnormality of sulfur amino acid metabolism (HP:0004339)2.03581782
77Delusions (HP:0000746)2.02624723
78Acute myeloid leukemia (HP:0004808)2.01668403
79Aplasia/Hypoplasia of the fovea (HP:0008060)1.98658817
80Hypoplasia of the fovea (HP:0007750)1.98658817
81Type I transferrin isoform profile (HP:0003642)1.95997280
82CNS demyelination (HP:0007305)1.93891187
83Abnormality of the gallbladder (HP:0005264)1.93807448
84Emotional lability (HP:0000712)1.93709876
85Hyperbilirubinemia (HP:0002904)1.92989717
86Abnormality of pyrimidine metabolism (HP:0004353)1.92740798
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91883390
88Abnormality of alanine metabolism (HP:0010916)1.91883390
89Hyperalaninemia (HP:0003348)1.91883390
90Exercise intolerance (HP:0003546)1.91063168
91Abnormally folded helix (HP:0008544)1.87123944
92Macrocytic anemia (HP:0001972)1.86771321
93Abnormal number of erythroid precursors (HP:0012131)1.83082237
94Breech presentation (HP:0001623)1.82699918
95Adenoma sebaceum (HP:0009720)1.81757056
96Angiofibromas (HP:0010615)1.81757056
97Abnormality of the carotid arteries (HP:0005344)1.80907047
98Conjunctival hamartoma (HP:0100780)1.80795793
99Abnormality of cells of the erythroid lineage (HP:0012130)1.80122298
100Abnormality of methionine metabolism (HP:0010901)1.79974632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.06081156
2SIK34.80131823
3EIF2AK14.34012284
4PBK3.54544068
5NEK13.35327792
6MAP3K33.23357363
7TTK2.71144775
8KSR12.67119738
9EIF2AK32.60263525
10PDK22.48663205
11CCNB12.37207947
12BCR2.34603461
13BUB12.29548562
14MST42.20256527
15SRPK12.10167283
16CDC72.04418966
17RIPK41.97506651
18CLK11.91406574
19KSR21.90056536
20NME11.89996262
21STK161.89151616
22NME21.84985719
23PLK41.75973923
24WEE11.69880193
25TSSK61.66689844
26BRSK21.65169179
27RAF11.57828283
28BRSK11.35450002
29BMPR21.31102340
30NTRK31.27325442
31CHEK21.21470059
32IRAK31.14831483
33MAP3K21.14516772
34PLK31.09389309
35MAP3K81.08683183
36NEK21.08483189
37WNK41.06782728
38SCYL20.95353074
39STK40.92583426
40PLK10.91396996
41ALK0.90023051
42ATR0.86978189
43MKNK10.84878324
44EEF2K0.83299107
45ILK0.82730606
46STK30.80369139
47CHEK10.80178594
48TAOK30.79133213
49PIK3CG0.78023935
50BRAF0.77998134
51RPS6KB20.77426497
52AKT30.76177847
53ICK0.72956954
54BMX0.70566907
55AURKB0.66469094
56PAK10.64337351
57EIF2AK20.63912979
58MINK10.63195840
59MARK30.59152304
60CDK20.55233999
61CDK10.54412973
62ATM0.52807005
63CSNK2A20.52558239
64CDK180.49825769
65ZAK0.48309305
66CSNK2A10.45586963
67VRK20.44292767
68NUAK10.41311274
69CSNK1E0.41211020
70MAPKAPK50.40888015
71MKNK20.40417925
72MAPKAPK20.39264184
73CDK70.38995897
74TRPM70.38757208
75STK100.37851226
76MAPKAPK30.37570800
77PIM10.37463766
78AURKA0.35958710
79DMPK0.34086476
80PAK40.33488221
81MAP3K120.32924480
82DYRK1A0.32212921
83MAP2K10.30154117
84CDK11A0.27192589
85RPS6KA50.26849828
86JAK20.26825520
87PLK20.26264042
88TEC0.25020610
89CDK150.22353381
90CDK140.21683565
91MAPK40.21049670
92AKT20.20836183
93MAPK140.19913598
94PRKCI0.18785452
95GSK3A0.18576757
96ERBB30.17513181
97GSK3B0.17316985
98LRRK20.16903606
99JAK30.16834802
100MAP3K10.15807285

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.98656056
2Proteasome_Homo sapiens_hsa030503.61041196
3DNA replication_Homo sapiens_hsa030303.43610608
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39719461
5Mismatch repair_Homo sapiens_hsa034303.17536970
6Ribosome_Homo sapiens_hsa030103.04143122
7Homologous recombination_Homo sapiens_hsa034402.94863646
8Parkinsons disease_Homo sapiens_hsa050122.83131957
9Oxidative phosphorylation_Homo sapiens_hsa001902.77444375
10RNA polymerase_Homo sapiens_hsa030202.69110304
11One carbon pool by folate_Homo sapiens_hsa006702.66298714
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53397717
13RNA transport_Homo sapiens_hsa030132.45671014
14Spliceosome_Homo sapiens_hsa030402.26643481
15Fanconi anemia pathway_Homo sapiens_hsa034602.15880094
16Huntingtons disease_Homo sapiens_hsa050162.02087522
17Nucleotide excision repair_Homo sapiens_hsa034201.98120771
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.95773984
19Basal transcription factors_Homo sapiens_hsa030221.85657298
20Pyrimidine metabolism_Homo sapiens_hsa002401.81858578
21Cell cycle_Homo sapiens_hsa041101.74276294
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.69326881
23Alzheimers disease_Homo sapiens_hsa050101.68977499
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67131440
25Carbon metabolism_Homo sapiens_hsa012001.62245859
26Biosynthesis of amino acids_Homo sapiens_hsa012301.60967720
27Protein export_Homo sapiens_hsa030601.59675849
28Base excision repair_Homo sapiens_hsa034101.56976308
29Non-homologous end-joining_Homo sapiens_hsa034501.48440172
30RNA degradation_Homo sapiens_hsa030181.41116075
31Pyruvate metabolism_Homo sapiens_hsa006201.40100359
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.38519425
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.37150508
34Fructose and mannose metabolism_Homo sapiens_hsa000511.36581623
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32795284
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.28912634
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28423112
38Steroid biosynthesis_Homo sapiens_hsa001001.21836025
39Purine metabolism_Homo sapiens_hsa002301.21241657
40Pentose phosphate pathway_Homo sapiens_hsa000301.18023591
41mRNA surveillance pathway_Homo sapiens_hsa030151.16078074
42Fatty acid elongation_Homo sapiens_hsa000621.08689548
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03549866
44Propanoate metabolism_Homo sapiens_hsa006400.99245745
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98095266
46Selenocompound metabolism_Homo sapiens_hsa004500.97992907
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96287176
48Glutathione metabolism_Homo sapiens_hsa004800.89612075
49Arginine biosynthesis_Homo sapiens_hsa002200.84770589
50Oocyte meiosis_Homo sapiens_hsa041140.83987922
51Cardiac muscle contraction_Homo sapiens_hsa042600.81540024
52Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77252214
53N-Glycan biosynthesis_Homo sapiens_hsa005100.76883878
54Sulfur relay system_Homo sapiens_hsa041220.73885482
55Metabolic pathways_Homo sapiens_hsa011000.73196527
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.71081562
57Olfactory transduction_Homo sapiens_hsa047400.66289120
58Epstein-Barr virus infection_Homo sapiens_hsa051690.63985673
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62980622
60Fatty acid metabolism_Homo sapiens_hsa012120.61409757
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.60201414
62Folate biosynthesis_Homo sapiens_hsa007900.59916381
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.58399877
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50455518
65Tyrosine metabolism_Homo sapiens_hsa003500.49821341
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47284997
67Butanoate metabolism_Homo sapiens_hsa006500.46325824
68HIF-1 signaling pathway_Homo sapiens_hsa040660.45214267
69p53 signaling pathway_Homo sapiens_hsa041150.44509835
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43838351
71Vitamin B6 metabolism_Homo sapiens_hsa007500.43412342
72Viral carcinogenesis_Homo sapiens_hsa052030.36901055
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33582542
74Acute myeloid leukemia_Homo sapiens_hsa052210.26031991
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.25651035
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25554172
77Arginine and proline metabolism_Homo sapiens_hsa003300.25436712
78Other glycan degradation_Homo sapiens_hsa005110.24033444
79Galactose metabolism_Homo sapiens_hsa000520.23137931
80Thyroid cancer_Homo sapiens_hsa052160.23008250
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22897674
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22523584
83Lysine degradation_Homo sapiens_hsa003100.21607162
84Sulfur metabolism_Homo sapiens_hsa009200.17160093
85Retinol metabolism_Homo sapiens_hsa008300.15273110
86Chronic myeloid leukemia_Homo sapiens_hsa052200.14622209
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13524937
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12830191
89Fatty acid biosynthesis_Homo sapiens_hsa000610.11982517
90MicroRNAs in cancer_Homo sapiens_hsa052060.11263512
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.08585776
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.06518374
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.05970999
94Prion diseases_Homo sapiens_hsa050200.04480398
95mTOR signaling pathway_Homo sapiens_hsa041500.03700508
96Peroxisome_Homo sapiens_hsa041460.03618339
97beta-Alanine metabolism_Homo sapiens_hsa004100.02782207
98Nitrogen metabolism_Homo sapiens_hsa009100.02172998
99Hepatitis B_Homo sapiens_hsa051610.02105631
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0030001

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