GABPB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.20773499
2protein localization to kinetochore (GO:0034501)4.11412943
3DNA strand elongation involved in DNA replication (GO:0006271)4.08728410
4piRNA metabolic process (GO:0034587)4.03400579
5DNA replication initiation (GO:0006270)4.01525378
6telomere maintenance via semi-conservative replication (GO:0032201)3.95956187
7synapsis (GO:0007129)3.94629736
8DNA strand elongation (GO:0022616)3.93698250
9DNA double-strand break processing (GO:0000729)3.74870512
10protein localization to chromosome, centromeric region (GO:0071459)3.73625379
11mitotic metaphase plate congression (GO:0007080)3.73210940
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.67198538
13telomere maintenance via recombination (GO:0000722)3.66094011
14regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.63342397
15DNA replication checkpoint (GO:0000076)3.62898514
16mitotic nuclear envelope disassembly (GO:0007077)3.59088075
17mitotic sister chromatid cohesion (GO:0007064)3.58816462
18mitotic recombination (GO:0006312)3.56612393
19exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54246964
20kinetochore organization (GO:0051383)3.52280449
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51001315
22regulation of mitotic spindle checkpoint (GO:1903504)3.51001315
23maturation of SSU-rRNA (GO:0030490)3.49314592
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.48349290
25nuclear pore complex assembly (GO:0051292)3.47855059
26mitotic chromosome condensation (GO:0007076)3.47651920
27CENP-A containing nucleosome assembly (GO:0034080)3.45550700
28nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.45537406
29dosage compensation (GO:0007549)3.44641107
30metaphase plate congression (GO:0051310)3.42385870
31ribosomal small subunit assembly (GO:0000028)3.41124792
32DNA replication-independent nucleosome organization (GO:0034724)3.38533204
33DNA replication-independent nucleosome assembly (GO:0006336)3.38533204
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.36348204
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36348204
36nuclear pore organization (GO:0006999)3.34713663
37replication fork processing (GO:0031297)3.32653592
38chromatin remodeling at centromere (GO:0031055)3.32206373
39nuclear envelope disassembly (GO:0051081)3.30808586
40membrane disassembly (GO:0030397)3.30808586
41nucleobase biosynthetic process (GO:0046112)3.29932743
42negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.29016445
43negative regulation of translation, ncRNA-mediated (GO:0040033)3.29016445
44regulation of translation, ncRNA-mediated (GO:0045974)3.29016445
45regulation of spindle organization (GO:0090224)3.27884754
46regulation of DNA endoreduplication (GO:0032875)3.26231283
47telomere maintenance via telomere lengthening (GO:0010833)3.24087520
48regulation of centriole replication (GO:0046599)3.22614603
49centriole replication (GO:0007099)3.22282346
50attachment of spindle microtubules to kinetochore (GO:0008608)3.20866646
51recombinational repair (GO:0000725)3.20218874
52neural tube formation (GO:0001841)3.17739899
53kinetochore assembly (GO:0051382)3.17441594
54double-strand break repair via homologous recombination (GO:0000724)3.17161538
55DNA methylation involved in gamete generation (GO:0043046)3.11757950
56DNA ligation (GO:0006266)3.08934987
57DNA deamination (GO:0045006)3.08388456
58positive regulation of mRNA metabolic process (GO:1903313)3.08106218
59protein localization to chromosome (GO:0034502)3.07839315
60establishment of chromosome localization (GO:0051303)3.06852632
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04840927
62positive regulation of mRNA processing (GO:0050685)3.03740015
63purine nucleobase biosynthetic process (GO:0009113)3.01541924
64mitotic sister chromatid segregation (GO:0000070)2.98235856
65behavioral response to nicotine (GO:0035095)2.92382496
66nucleotide-excision repair, DNA gap filling (GO:0006297)2.90970398
67RNA destabilization (GO:0050779)2.90433528
68DNA duplex unwinding (GO:0032508)2.89623332
69regulation of sister chromatid cohesion (GO:0007063)2.89623328
70viral transcription (GO:0019083)2.89046735
71single strand break repair (GO:0000012)2.89039427
72DNA topological change (GO:0006265)2.88651165
73DNA geometric change (GO:0032392)2.88209126
74sister chromatid segregation (GO:0000819)2.88109268
75definitive hemopoiesis (GO:0060216)2.87753570
76positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.87278308
77regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.87278308
78histone exchange (GO:0043486)2.86772489
79regulation of nuclear cell cycle DNA replication (GO:0033262)2.85986025
80somatic diversification of immune receptors (GO:0002200)2.85467065
81monoubiquitinated protein deubiquitination (GO:0035520)2.85294725
82maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85106366
83rRNA catabolic process (GO:0016075)2.84940326
84translational termination (GO:0006415)2.84656149
85formation of translation preinitiation complex (GO:0001731)2.82872380
86positive regulation of mRNA catabolic process (GO:0061014)2.82024465
87IMP biosynthetic process (GO:0006188)2.81827431
88ribosome biogenesis (GO:0042254)2.81258656
893-UTR-mediated mRNA stabilization (GO:0070935)2.79738214
90negative regulation of RNA splicing (GO:0033119)2.78204155
91reciprocal DNA recombination (GO:0035825)2.77908337
92reciprocal meiotic recombination (GO:0007131)2.77908337
93regulation of telomere maintenance via telomerase (GO:0032210)2.76914070
94chromatin assembly or disassembly (GO:0006333)2.75022949
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74965811
96positive regulation of mRNA 3-end processing (GO:0031442)2.74617903
97DNA demethylation (GO:0080111)2.74577734
98meiotic chromosome segregation (GO:0045132)2.73431055
99intra-S DNA damage checkpoint (GO:0031573)2.72568652
100positive regulation of gamma-delta T cell activation (GO:0046645)2.72393068
101microtubule depolymerization (GO:0007019)2.72053662
102nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:0000288)2.71982170
103somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.71674907
104isotype switching (GO:0045190)2.71674907
105somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.71674907
106translesion synthesis (GO:0019985)2.71431725
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71005045
108ATP-dependent chromatin remodeling (GO:0043044)2.70700532
109somatic cell DNA recombination (GO:0016444)2.70373206
110somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.70373206
111telomere maintenance (GO:0000723)2.70084597
112regulation of chromosome segregation (GO:0051983)2.69360813
113gene silencing by RNA (GO:0031047)2.68452235
114ribosome assembly (GO:0042255)2.68363628
115telomere organization (GO:0032200)2.68286341
116regulation of double-strand break repair via homologous recombination (GO:0010569)2.66417623
117DNA replication-dependent nucleosome assembly (GO:0006335)2.66405449
118DNA replication-dependent nucleosome organization (GO:0034723)2.66405449
119somatic diversification of immunoglobulins (GO:0016445)2.66215110
120mitotic G2/M transition checkpoint (GO:0044818)2.65008257
121mismatch repair (GO:0006298)2.64096744
122V(D)J recombination (GO:0033151)2.64074083
123positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63807783
124regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63807783
125ribonucleoprotein complex biogenesis (GO:0022613)2.63730475
126histone mRNA metabolic process (GO:0008334)2.63305979
127nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63155296
128positive regulation of DNA-dependent DNA replication (GO:2000105)2.62969787
129spindle checkpoint (GO:0031577)2.62957705
130negative regulation of DNA recombination (GO:0045910)2.62165039
131postreplication repair (GO:0006301)2.62068784
132positive regulation of chromosome segregation (GO:0051984)2.62037723
133pore complex assembly (GO:0046931)2.61820262
134translational initiation (GO:0006413)2.60968152
135nuclear envelope organization (GO:0006998)2.60630646
136negative regulation of chromosome segregation (GO:0051985)2.59236407
137DNA recombination (GO:0006310)2.59190419
138negative regulation of mitotic sister chromatid separation (GO:2000816)2.58631488
139negative regulation of mitotic sister chromatid segregation (GO:0033048)2.58631488
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.58631488
141negative regulation of sister chromatid segregation (GO:0033046)2.58631488
142spindle assembly checkpoint (GO:0071173)2.58430624
143DNA conformation change (GO:0071103)2.57775641
144chromosome segregation (GO:0007059)2.56162877
145translational elongation (GO:0006414)2.55248477
146mitotic spindle assembly checkpoint (GO:0007094)2.54643627
147mRNA splicing, via spliceosome (GO:0000398)2.54421772
148RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.54421772
149RNA splicing, via transesterification reactions (GO:0000375)2.54108652
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.54045026
151rRNA modification (GO:0000154)2.52930360
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.52174601
153histone H3-K9 methylation (GO:0051567)2.51142020
154ribosomal small subunit biogenesis (GO:0042274)2.50795640
155negative regulation of histone methylation (GO:0031061)2.50712646
156histone mRNA catabolic process (GO:0071044)2.50320532
157positive regulation of B cell differentiation (GO:0045579)2.50057291
158IMP metabolic process (GO:0046040)2.49720110
159regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.49159851
160double-strand break repair (GO:0006302)2.47465747
161seminiferous tubule development (GO:0072520)2.47109833
162negative regulation of cell cycle G2/M phase transition (GO:1902750)2.46938273
163regulation of mRNA 3-end processing (GO:0031440)2.46570743
164positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45067200
165regulation of helicase activity (GO:0051095)2.43722747
166regulation of establishment of cell polarity (GO:2000114)2.43648690
167DNA modification (GO:0006304)2.42975785
168mitotic G2 DNA damage checkpoint (GO:0007095)2.42839883
169somatic recombination of immunoglobulin gene segments (GO:0016447)2.42047579
170protein K6-linked ubiquitination (GO:0085020)2.41880108
171regulation of centrosome cycle (GO:0046605)2.40939688
172regulation of telomere maintenance (GO:0032204)2.40298172
173regulation of centrosome duplication (GO:0010824)2.39467619
174termination of RNA polymerase II transcription (GO:0006369)2.39312507
175peptidyl-lysine trimethylation (GO:0018023)2.38994314
176histone H2A acetylation (GO:0043968)2.36667325
177mRNA splice site selection (GO:0006376)2.36655591
178sister chromatid cohesion (GO:0007062)2.35698652
179DNA catabolic process, exonucleolytic (GO:0000738)2.35399512
180negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.33862031
181DNA methylation or demethylation (GO:0044728)2.33740347

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.11814639
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53028715
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.95345513
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.54152803
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.51195677
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.26964083
7ZNF274_21170338_ChIP-Seq_K562_Hela3.07376452
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92242751
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.74646444
10EWS_26573619_Chip-Seq_HEK293_Human2.71047308
11VDR_22108803_ChIP-Seq_LS180_Human2.65348311
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58850320
13MYC_22102868_ChIP-Seq_BL_Human2.52808579
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37549413
15FUS_26573619_Chip-Seq_HEK293_Human2.32835833
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31696092
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.30910484
18IGF1R_20145208_ChIP-Seq_DFB_Human2.27331272
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.21490243
20* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.19678651
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13498830
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.12826990
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.09822888
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.09536919
25* VDR_23849224_ChIP-Seq_CD4+_Human2.08908375
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.07724325
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05953397
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01379562
29XRN2_22483619_ChIP-Seq_HELA_Human2.00445527
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92304608
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90706341
32ETS1_20019798_ChIP-Seq_JURKAT_Human1.88844116
33AR_21909140_ChIP-Seq_LNCAP_Human1.87123761
34TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.87106345
35IRF1_19129219_ChIP-ChIP_H3396_Human1.85294202
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84596330
37FOXP3_21729870_ChIP-Seq_TREG_Human1.82920759
38CIITA_25753668_ChIP-Seq_RAJI_Human1.79781056
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79477805
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.77937397
41TAF15_26573619_Chip-Seq_HEK293_Human1.77724096
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74583271
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74350010
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.74173791
45* ER_23166858_ChIP-Seq_MCF-7_Human1.74131903
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71266646
47HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70394660
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70165254
49* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68713812
50* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68236998
51IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68112785
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67010413
53SCL_19346495_ChIP-Seq_HPC-7_Human1.63888000
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62352301
55* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61302298
56MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59975906
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59819441
58VDR_21846776_ChIP-Seq_THP-1_Human1.58959649
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.58875797
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57815012
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57624347
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57110423
63POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56092512
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55791093
65ELK1_19687146_ChIP-ChIP_HELA_Human1.55145075
66P300_19829295_ChIP-Seq_ESCs_Human1.54854955
67* GABP_19822575_ChIP-Seq_HepG2_Human1.54399425
68MYB_26560356_Chip-Seq_TH2_Human1.53756681
69TTF2_22483619_ChIP-Seq_HELA_Human1.51483964
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49214762
71GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48622931
72SPI1_23547873_ChIP-Seq_NB4_Human1.48477093
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.46277790
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44546404
75DCP1A_22483619_ChIP-Seq_HELA_Human1.42676192
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41988165
77MYB_26560356_Chip-Seq_TH1_Human1.40957349
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40550246
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36208263
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.35042389
81KDM5A_27292631_Chip-Seq_BREAST_Human1.34874659
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34199226
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.33528342
84MAF_26560356_Chip-Seq_TH1_Human1.32478749
85ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31829388
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31311196
87GBX2_23144817_ChIP-Seq_PC3_Human1.31088712
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29855881
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28825486
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27513904
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26456276
92UTX_26944678_Chip-Seq_JUKART_Human1.24828690
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23860764
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23753039
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.22375259
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21741900
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21265431
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20666227
99IRF8_22096565_ChIP-ChIP_GC-B_Human1.20037514
100* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19716127
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16393611
102TFEB_21752829_ChIP-Seq_HELA_Human1.15498192
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14290816
104TP53_22573176_ChIP-Seq_HFKS_Human1.12513747
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11408864
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11308898
107* RUNX1_22412390_ChIP-Seq_EML_Mouse1.10517004
108TCF7_22412390_ChIP-Seq_EML_Mouse1.09573365
109GATA3_26560356_Chip-Seq_TH2_Human1.09499217
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.08781449
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07093932
112RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.07011273
113IRF8_21731497_ChIP-ChIP_J774_Mouse1.04464167
114IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04218167
115CBP_20019798_ChIP-Seq_JUKART_Human1.04218167
116* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03177240
117* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03034991
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02821468
119VDR_24763502_ChIP-Seq_THP-1_Human1.02779700
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02438901
121* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01563561
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01519166
123THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00809909
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.00613660
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.00094066
126BP1_19119308_ChIP-ChIP_Hs578T_Human0.99230775
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98413378
128* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97262868
129ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96302773
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96112625
131FLI1_21867929_ChIP-Seq_TH2_Mouse0.94648430
132MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94343884
133MAF_26560356_Chip-Seq_TH2_Human0.92895746
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92866857
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92329066
136BRD4_27068464_Chip-Seq_AML-cells_Mouse0.91319533
137STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91001640
138SRF_21415370_ChIP-Seq_HL-1_Mouse0.90761707
139MYC_18940864_ChIP-ChIP_HL60_Human0.89568145
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88867015
141STAT3_23295773_ChIP-Seq_U87_Human0.86469101
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.85892446
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85446096
144NANOG_16153702_ChIP-ChIP_HESCs_Human0.84668149
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84649877
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84126903
147TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83039395
148FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82203832
149SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82105326
150NFE2_27457419_Chip-Seq_LIVER_Mouse0.82017285
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.81821443
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.81269899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.21565420
2MP0010094_abnormal_chromosome_stability3.77747536
3MP0008057_abnormal_DNA_replication3.75218349
4MP0002396_abnormal_hematopoietic_system3.71272251
5MP0006292_abnormal_olfactory_placode3.63747678
6MP0003111_abnormal_nucleus_morphology3.49026160
7MP0003077_abnormal_cell_cycle3.33965314
8MP0004957_abnormal_blastocyst_morpholog2.97587136
9MP0008007_abnormal_cellular_replicative2.75762091
10MP0008058_abnormal_DNA_repair2.57616390
11MP0003763_abnormal_thymus_physiology2.50936541
12MP0004808_abnormal_hematopoietic_stem2.45091471
13MP0000569_abnormal_digit_pigmentation2.36612601
14MP0000685_abnormal_immune_system2.12780643
15MP0002009_preneoplasia2.11417173
16MP0000490_abnormal_crypts_of2.06001995
17MP0002398_abnormal_bone_marrow2.02685063
18MP0001545_abnormal_hematopoietic_system1.98638075
19MP0005397_hematopoietic_system_phenotyp1.98638075
20MP0006072_abnormal_retinal_apoptosis1.95303777
21MP0001800_abnormal_humoral_immune1.92031242
22MP0000350_abnormal_cell_proliferation1.90746055
23MP0010352_gastrointestinal_tract_polyps1.89860506
24MP0001835_abnormal_antigen_presentation1.87400460
25MP0008877_abnormal_DNA_methylation1.86973460
26MP0005671_abnormal_response_to1.84740224
27MP0000703_abnormal_thymus_morphology1.78369725
28MP0009333_abnormal_splenocyte_physiolog1.75532753
29MP0005084_abnormal_gallbladder_morpholo1.73627388
30MP0002722_abnormal_immune_system1.68164280
31MP0000689_abnormal_spleen_morphology1.66216602
32MP0002638_abnormal_pupillary_reflex1.64145350
33MP0008932_abnormal_embryonic_tissue1.63468874
34MP0002452_abnormal_antigen_presenting1.60642931
35MP0000716_abnormal_immune_system1.59190779
36MP0010307_abnormal_tumor_latency1.57413804
37MP0002420_abnormal_adaptive_immunity1.57412982
38MP0003786_premature_aging1.55946096
39MP0001819_abnormal_immune_cell1.55483322
40MP0001730_embryonic_growth_arrest1.55369759
41MP0009278_abnormal_bone_marrow1.51495878
42MP0002723_abnormal_immune_serum1.50681025
43MP0002019_abnormal_tumor_incidence1.50679353
44MP0009697_abnormal_copulation1.49208642
45MP0002429_abnormal_blood_cell1.48753507
46MP0002405_respiratory_system_inflammati1.45868666
47MP0009785_altered_susceptibility_to1.42627538
48MP0003890_abnormal_embryonic-extraembry1.42057462
49MP0005253_abnormal_eye_physiology1.35982765
50MP0003123_paternal_imprinting1.33981657
51MP0001697_abnormal_embryo_size1.32812582
52MP0000372_irregular_coat_pigmentation1.31866899
53MP0002928_abnormal_bile_duct1.31862465
54MP0005380_embryogenesis_phenotype1.31791814
55MP0001672_abnormal_embryogenesis/_devel1.31791814
56MP0000313_abnormal_cell_death1.31781706
57MP0005389_reproductive_system_phenotype1.31451656
58MP0001919_abnormal_reproductive_system1.31294950
59MP0006054_spinal_hemorrhage1.28030937
60MP0005000_abnormal_immune_tolerance1.25932550
61MP0010155_abnormal_intestine_physiology1.25807787
62MP0002138_abnormal_hepatobiliary_system1.23449974
63MP0004147_increased_porphyrin_level1.23246330
64MP0005387_immune_system_phenotype1.23187120
65MP0001790_abnormal_immune_system1.23187120
66MP0002166_altered_tumor_susceptibility1.22764923
67MP0001853_heart_inflammation1.22465136
68MP0002160_abnormal_reproductive_system1.21862805
69MP0005025_abnormal_response_to1.21854033
70MP0005646_abnormal_pituitary_gland1.20466678
71MP0001873_stomach_inflammation1.20026074
72MP0003984_embryonic_growth_retardation1.19462653
73MP0000465_gastrointestinal_hemorrhage1.18963889
74MP0002088_abnormal_embryonic_growth/wei1.17789395
75* MP0002080_prenatal_lethality1.17386716
76MP0002736_abnormal_nociception_after1.16832226
77MP0000427_abnormal_hair_cycle1.15500869
78MP0000858_altered_metastatic_potential1.15482061
79MP0002102_abnormal_ear_morphology1.15225052
80MP0002086_abnormal_extraembryonic_tissu1.15076310
81MP0003121_genomic_imprinting1.12612302
82MP0001968_abnormal_touch/_nociception1.11917479
83MP0008789_abnormal_olfactory_epithelium1.09982821
84MP0003436_decreased_susceptibility_to1.08795923
85MP0000631_abnormal_neuroendocrine_gland1.08250130
86MP0002006_tumorigenesis1.08167923
87MP0005076_abnormal_cell_differentiation1.07855694
88MP0001986_abnormal_taste_sensitivity1.07156657
89MP0005551_abnormal_eye_electrophysiolog1.02688574
90MP0004197_abnormal_fetal_growth/weight/1.02460261
91MP0002085_abnormal_embryonic_tissue1.01957446
92MP0003303_peritoneal_inflammation1.00456224
93MP0003567_abnormal_fetal_cardiomyocyte0.99323649
94MP0002148_abnormal_hypersensitivity_rea0.98815497
95MP0005220_abnormal_exocrine_pancreas0.98663975
96MP0003880_abnormal_central_pattern0.98346398
97MP0002084_abnormal_developmental_patter0.96893627
98MP0004142_abnormal_muscle_tone0.96542833
99MP0005464_abnormal_platelet_physiology0.95930967
100MP0000383_abnormal_hair_follicle0.95758883
101MP0006276_abnormal_autonomic_nervous0.94660528
102MP0005647_abnormal_sex_gland0.94624563
103MP0004133_heterotaxia0.93459693
104MP0002132_abnormal_respiratory_system0.92111806
105MP0003195_calcinosis0.91812264
106MP0002419_abnormal_innate_immunity0.91562520
107MP0003300_gastrointestinal_ulcer0.90734034
108MP0003866_abnormal_defecation0.89882689
109MP0002095_abnormal_skin_pigmentation0.88367583
110MP0005174_abnormal_tail_pigmentation0.88294858
111MP0004947_skin_inflammation0.88201821
112MP0003698_abnormal_male_reproductive0.87228792
113MP0002210_abnormal_sex_determination0.85766253
114MP0008995_early_reproductive_senescence0.84495695
115MP0002751_abnormal_autonomic_nervous0.83839729
116MP0003724_increased_susceptibility_to0.83806111
117MP0001293_anophthalmia0.83295492
118MP0005367_renal/urinary_system_phenotyp0.81186161
119MP0000516_abnormal_urinary_system0.81186161
120MP0001286_abnormal_eye_development0.80659785
121MP0001188_hyperpigmentation0.80000057
122MP0002234_abnormal_pharynx_morphology0.78316585
123MP0003943_abnormal_hepatobiliary_system0.77522984
124MP0001845_abnormal_inflammatory_respons0.77366057
125MP0008872_abnormal_physiological_respon0.76916798
126MP0001851_eye_inflammation0.76429978
127MP0005075_abnormal_melanosome_morpholog0.76219035
128MP0005391_vision/eye_phenotype0.75421947
129MP0003448_altered_tumor_morphology0.75061916
130MP0005394_taste/olfaction_phenotype0.74581142
131MP0005499_abnormal_olfactory_system0.74581142
132MP0001929_abnormal_gametogenesis0.73867554
133MP0001119_abnormal_female_reproductive0.73584503
134MP0003221_abnormal_cardiomyocyte_apopto0.72688001
135MP0003787_abnormal_imprinting0.72217852
136MP0001145_abnormal_male_reproductive0.71853483
137MP0001501_abnormal_sleep_pattern0.71730848
138MP0000477_abnormal_intestine_morphology0.68402598
139MP0003718_maternal_effect0.68298272
140MP0001502_abnormal_circadian_rhythm0.66819424
141MP0005395_other_phenotype0.66046323
142MP0009703_decreased_birth_body0.64546313
143MP0000653_abnormal_sex_gland0.64261579
144MP0004264_abnormal_extraembryonic_tissu0.63958882
145MP0002938_white_spotting0.63726712
146MP0009053_abnormal_anal_canal0.62707510
147MP0002877_abnormal_melanocyte_morpholog0.62259951

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.58880876
2Chromsome breakage (HP:0040012)3.52935265
3Aplastic anemia (HP:0001915)3.38495016
4IgM deficiency (HP:0002850)3.36740240
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.34398229
6Reticulocytopenia (HP:0001896)3.34328250
7Pancreatic cysts (HP:0001737)3.25086099
8Patellar aplasia (HP:0006443)3.18104284
9Thrombocytosis (HP:0001894)3.05513424
10Medulloblastoma (HP:0002885)3.00525990
11Acute myeloid leukemia (HP:0004808)2.98774937
12Volvulus (HP:0002580)2.96136362
13Aplasia/Hypoplasia of the patella (HP:0006498)2.95546667
14Abnormality of the fingertips (HP:0001211)2.93714922
15Myelodysplasia (HP:0002863)2.88774152
16Myositis (HP:0100614)2.87514557
17Breast hypoplasia (HP:0003187)2.81806705
18Acute lymphatic leukemia (HP:0006721)2.80634537
19Muscle fiber atrophy (HP:0100295)2.78850984
20IgG deficiency (HP:0004315)2.73350370
21Recurrent bronchitis (HP:0002837)2.73162473
22Chronic otitis media (HP:0000389)2.72982435
23Abnormality of chromosome stability (HP:0003220)2.69373157
24Colon cancer (HP:0003003)2.64207558
25Abnormality of midbrain morphology (HP:0002418)2.60667012
26Molar tooth sign on MRI (HP:0002419)2.60667012
27Pancreatic fibrosis (HP:0100732)2.58030768
28Abnormality of the labia minora (HP:0012880)2.53380887
29Abnormality of B cell number (HP:0010975)2.52877262
30B lymphocytopenia (HP:0010976)2.52877262
31Amaurosis fugax (HP:0100576)2.51850427
32Stomach cancer (HP:0012126)2.51556137
33Type 2 muscle fiber atrophy (HP:0003554)2.47084088
34Protruding tongue (HP:0010808)2.44924311
35Abnormality of the preputium (HP:0100587)2.44322133
36Lymphoma (HP:0002665)2.43808404
37True hermaphroditism (HP:0010459)2.41161170
38Abnormality of T cells (HP:0002843)2.40858329
39Meckel diverticulum (HP:0002245)2.40703376
40Facial hemangioma (HP:0000329)2.38521323
41Pendular nystagmus (HP:0012043)2.37929896
42Elevated erythrocyte sedimentation rate (HP:0003565)2.36996521
43Abnormality of the renal cortex (HP:0011035)2.36457902
44Abolished electroretinogram (ERG) (HP:0000550)2.34940726
45Basal cell carcinoma (HP:0002671)2.33579629
46Increased nuchal translucency (HP:0010880)2.33043409
47Recurrent viral infections (HP:0004429)2.32154063
48Abnormality of the ileum (HP:0001549)2.31466262
49Panhypogammaglobulinemia (HP:0003139)2.30341021
50T lymphocytopenia (HP:0005403)2.29734085
51Microretrognathia (HP:0000308)2.29577301
52Abnormality of cells of the erythroid lineage (HP:0012130)2.26786003
53Nephronophthisis (HP:0000090)2.25127348
54Chronic hepatic failure (HP:0100626)2.24728489
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.23478304
56Dyschromatopsia (HP:0007641)2.23164009
57Carpal bone hypoplasia (HP:0001498)2.22953348
58Oral leukoplakia (HP:0002745)2.22761958
59Entropion (HP:0000621)2.22693915
60Prominent nose (HP:0000448)2.20653325
61Bile duct proliferation (HP:0001408)2.19227118
62Abnormal biliary tract physiology (HP:0012439)2.19227118
63Agnosia (HP:0010524)2.19058784
64Fair hair (HP:0002286)2.18462852
65Abnormality of T cell number (HP:0011839)2.18040182
66Ectopic kidney (HP:0000086)2.17408321
67Abnormal number of erythroid precursors (HP:0012131)2.16669393
68Renal cortical cysts (HP:0000803)2.16519227
69Congenital stationary night blindness (HP:0007642)2.16377539
70Abnormality of T cell physiology (HP:0011840)2.15329492
71Severe combined immunodeficiency (HP:0004430)2.15147351
72Hyperventilation (HP:0002883)2.13175899
73Abnormality of the prostate (HP:0008775)2.07474342
74Abnormality of DNA repair (HP:0003254)2.07470552
75Hypoplasia of the pons (HP:0012110)2.07233039
76Recurrent fungal infections (HP:0002841)2.06420686
77Abnormality of the renal medulla (HP:0100957)2.06092613
78Stomatitis (HP:0010280)2.05672274
79Thyroiditis (HP:0100646)2.04704289
80Pallor (HP:0000980)2.04321567
81Abnormality of the pons (HP:0007361)2.04234876
82Supernumerary spleens (HP:0009799)2.03043131
83Bone marrow hypocellularity (HP:0005528)2.02562639
84Proximal placement of thumb (HP:0009623)2.02543519
85Selective tooth agenesis (HP:0001592)2.02510480
86Retrobulbar optic neuritis (HP:0100654)2.02203602
87Optic neuritis (HP:0100653)2.02203602
88Combined immunodeficiency (HP:0005387)2.01814679
89Duodenal stenosis (HP:0100867)2.00301778
90Small intestinal stenosis (HP:0012848)2.00301778
91Poikiloderma (HP:0001029)1.99369099
92Neoplasm of the oral cavity (HP:0100649)1.98939101
93Asplenia (HP:0001746)1.98872251
94Rhabdomyosarcoma (HP:0002859)1.98384175
95Abnormal delayed hypersensitivity skin test (HP:0002963)1.97569796
96Broad-based gait (HP:0002136)1.96742296
97Abnormality of eosinophils (HP:0001879)1.96665083
98Abnormality of the carotid arteries (HP:0005344)1.95855642
99Absent thumb (HP:0009777)1.95738513
100Cellulitis (HP:0100658)1.94478725
101Orchitis (HP:0100796)1.94356063
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.94309731
103Deviation of the thumb (HP:0009603)1.94149515
104Abnormality of cells of the lymphoid lineage (HP:0012140)1.92308934
105Optic nerve hypoplasia (HP:0000609)1.92207641
106Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92044375
107Lymphopenia (HP:0001888)1.91750109
108Neoplasm of the adrenal cortex (HP:0100641)1.91111744
109Type II lissencephaly (HP:0007260)1.90805019
110Cutis marmorata (HP:0000965)1.90101045
111Aplasia/Hypoplasia of the fovea (HP:0008060)1.89660519
112Hypoplasia of the fovea (HP:0007750)1.89660519
113Long eyelashes (HP:0000527)1.89638741
114Clubbing of toes (HP:0100760)1.88325520
115Abnormality of the anterior horn cell (HP:0006802)1.88206420
116Degeneration of anterior horn cells (HP:0002398)1.88206420
117Capillary hemangiomas (HP:0005306)1.87663959
118Premature graying of hair (HP:0002216)1.86917150
119Congenital, generalized hypertrichosis (HP:0004540)1.86864830
120Pulmonary fibrosis (HP:0002206)1.86790230
121Broad palm (HP:0001169)1.86514075
122Nephroblastoma (Wilms tumor) (HP:0002667)1.86424841
123Atresia of the external auditory canal (HP:0000413)1.83830610
124Abnormality of the duodenum (HP:0002246)1.83708898
125Dandy-Walker malformation (HP:0001305)1.82464468
126Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81503292
127Embryonal renal neoplasm (HP:0011794)1.81446237
128Autoimmune hemolytic anemia (HP:0001890)1.81016279
129Aplasia/Hypoplasia of the spleen (HP:0010451)1.80551454
130Nasal polyposis (HP:0100582)1.80454620
131Oligodactyly (hands) (HP:0001180)1.80336691
132IgA deficiency (HP:0002720)1.80194963
133Sloping forehead (HP:0000340)1.79983282
13411 pairs of ribs (HP:0000878)1.76745931
135Pancytopenia (HP:0001876)1.76133819
136Recurrent abscess formation (HP:0002722)1.75638786
137Slender long bone (HP:0003100)1.74559906
138Gonadotropin excess (HP:0000837)1.73687151
139Abnormal number of incisors (HP:0011064)1.73539936
140Intestinal atresia (HP:0011100)1.73222005
141Agammaglobulinemia (HP:0004432)1.72901370
142Neoplasm of the pancreas (HP:0002894)1.72302542
143Meningitis (HP:0001287)1.70893973
144Ependymoma (HP:0002888)1.70844333
145Small hand (HP:0200055)1.70236483
146Hypoplastic iliac wings (HP:0002866)1.70037810
147Neoplasm of the tracheobronchial system (HP:0100552)1.66723444
148Attenuation of retinal blood vessels (HP:0007843)1.66410826
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.65614996
150Eosinophilia (HP:0001880)1.64769684
151Optic nerve coloboma (HP:0000588)1.64321903
152Breast carcinoma (HP:0003002)1.64193392
153Duplicated collecting system (HP:0000081)1.63681135
154Abnormality of the fovea (HP:0000493)1.63485951
155Cerebellar dysplasia (HP:0007033)1.63361335
156Hypothermia (HP:0002045)1.63293644
157Abnormality of the renal collecting system (HP:0004742)1.63020142
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.61225189
159Short tibia (HP:0005736)1.60834969
160Generalized hypopigmentation of hair (HP:0011358)1.59016730
161Abnormal lung lobation (HP:0002101)1.57995817
162Lissencephaly (HP:0001339)1.57793670
163Gaze-evoked nystagmus (HP:0000640)1.57561956
164Triphalangeal thumb (HP:0001199)1.57391450

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.81350434
2WEE13.68447845
3CDC73.56279121
4BUB13.17692377
5ZAK2.95212730
6ACVR1B2.72210615
7NME22.71910427
8TRIM282.61745840
9NUAK12.60725520
10MAP4K12.48288464
11EEF2K2.43694398
12BRSK22.39848261
13BMPR1B2.26351477
14NEK22.25525948
15SRPK12.20859577
16STK161.96912603
17RPS6KA41.96350818
18STK101.93562222
19DYRK31.82619702
20TXK1.77525615
21PINK11.75362977
22TAOK31.73476355
23MAP4K21.73361714
24EIF2AK11.70749765
25FLT31.70218835
26TGFBR11.67345967
27MAPK131.60000721
28TEC1.59182785
29MKNK11.58899355
30RPS6KB21.57258402
31MAP3K101.55589196
32TSSK61.55050842
33VRK11.51555132
34JAK31.48600059
35CDK41.46038805
36PLK41.45687127
37CDK71.44936979
38TIE11.40633839
39PLK11.38693603
40KIT1.35959355
41CCNB11.35691778
42BTK1.34319892
43ATR1.33924833
44CDK121.31817017
45ZAP701.31554706
46ERBB31.30945618
47CDK81.28023706
48TAF11.26865580
49TTK1.24863164
50MKNK21.24376587
51PIM11.22387528
52AURKB1.21860401
53CASK1.15247029
54MAP2K31.15219207
55BCR1.12464617
56CHEK21.11983467
57MAP3K81.07352321
58BRD41.07142459
59SIK31.06824936
60INSRR1.06791712
61STK41.05615107
62ITK1.05212856
63PLK31.05046777
64MAPKAPK31.05027367
65WNK31.04740766
66IKBKB1.01885785
67TNIK1.01807909
68NLK0.99084227
69GRK10.98430320
70MAP3K40.96067714
71EIF2AK30.96043449
72CDK60.95838053
73CSF1R0.95513853
74BRSK10.95355270
75CHEK10.93488507
76VRK20.92824065
77MELK0.92750548
78AKT30.92184985
79KDR0.91026709
80ADRBK20.88059914
81TESK20.87419804
82LRRK20.84198949
83CDK90.84004667
84BMPR20.82124247
85CSNK1G10.78793633
86PBK0.77683488
87GRK60.76803323
88TBK10.76782738
89TYK20.76514836
90CHUK0.76394390
91PASK0.76312608
92STK30.75357226
93PAK40.74905935
94IRAK40.74766382
95IKBKE0.73224250
96SCYL20.70780951
97TAOK10.70575381
98DYRK20.69581582
99CDK30.69554643
100PIM20.68825546
101CDK190.68818719
102ATM0.68304776
103CSNK1G30.68180494
104TLK10.66951350
105PIK3CA0.65601218
106CSNK1G20.64399325
107CDK20.62305777
108SYK0.61635367
109CLK10.61613478
110PNCK0.60149916
111TGFBR20.59638284
112MAP3K50.56718673
113IRAK10.55399868
114LCK0.54734411
115FGFR20.54073593
116CSNK1A1L0.53460406
117NEK90.53183159
118CAMKK20.52870893
119AURKA0.52557106
120SGK20.52540846
121MST40.52289593
122MAP3K130.51926699
123RPS6KA50.50608797
124ALK0.50315320
125LYN0.49910488
126MAP2K70.49352719
127PLK20.48273474
128STK240.47237758
129EIF2AK20.46264445
130FES0.45916713
131PRKCQ0.45295655
132MAP3K60.44917141
133MAP3K140.44758565
134HIPK20.43731332
135HCK0.42448267
136CDK10.41962390
137CSNK2A10.38574754
138PKN20.37525318
139CSNK2A20.36716809
140MAPKAPK20.35895352
141BLK0.34859844
142MARK30.33793541
143RPS6KB10.33790666
144NEK10.32405301
145MAP3K30.31199910

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30886577
2Mismatch repair_Homo sapiens_hsa034303.57663012
3Spliceosome_Homo sapiens_hsa030402.84856394
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82772523
5Cell cycle_Homo sapiens_hsa041102.77712755
6Base excision repair_Homo sapiens_hsa034102.68979380
7Homologous recombination_Homo sapiens_hsa034402.59624253
8RNA transport_Homo sapiens_hsa030132.51582407
9Ribosome_Homo sapiens_hsa030102.34124882
10RNA polymerase_Homo sapiens_hsa030202.31756228
11Nucleotide excision repair_Homo sapiens_hsa034202.30402223
12Primary immunodeficiency_Homo sapiens_hsa053402.08774907
13Fanconi anemia pathway_Homo sapiens_hsa034601.97057928
14Non-homologous end-joining_Homo sapiens_hsa034501.92876145
15Pyrimidine metabolism_Homo sapiens_hsa002401.91564008
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91010376
17Basal transcription factors_Homo sapiens_hsa030221.88117902
18p53 signaling pathway_Homo sapiens_hsa041151.81641442
19RNA degradation_Homo sapiens_hsa030181.81214256
20Protein export_Homo sapiens_hsa030601.70443345
21mRNA surveillance pathway_Homo sapiens_hsa030151.67032593
22One carbon pool by folate_Homo sapiens_hsa006701.64395503
23Proteasome_Homo sapiens_hsa030501.63937365
24Herpes simplex infection_Homo sapiens_hsa051681.63295167
25Phototransduction_Homo sapiens_hsa047441.58080576
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.52135392
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48605883
28Antigen processing and presentation_Homo sapiens_hsa046121.45823243
29Selenocompound metabolism_Homo sapiens_hsa004501.44212632
30Epstein-Barr virus infection_Homo sapiens_hsa051691.43417876
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41218456
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40132494
33Measles_Homo sapiens_hsa051621.35328082
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28231447
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25970810
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.25742107
37Viral carcinogenesis_Homo sapiens_hsa052031.19791720
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17340329
39T cell receptor signaling pathway_Homo sapiens_hsa046601.13592067
40B cell receptor signaling pathway_Homo sapiens_hsa046621.13300662
41HTLV-I infection_Homo sapiens_hsa051661.07373960
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05215097
43Nitrogen metabolism_Homo sapiens_hsa009101.01484569
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00986005
45Leishmaniasis_Homo sapiens_hsa051400.99669691
46Hepatitis B_Homo sapiens_hsa051610.97783745
47Alcoholism_Homo sapiens_hsa050340.97488959
48Purine metabolism_Homo sapiens_hsa002300.96083774
49Small cell lung cancer_Homo sapiens_hsa052220.94862888
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94806624
51Hematopoietic cell lineage_Homo sapiens_hsa046400.94787539
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.94199259
53Legionellosis_Homo sapiens_hsa051340.92380860
54MicroRNAs in cancer_Homo sapiens_hsa052060.91928345
55Apoptosis_Homo sapiens_hsa042100.90722655
56Acute myeloid leukemia_Homo sapiens_hsa052210.90433906
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89805007
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88663970
59Type I diabetes mellitus_Homo sapiens_hsa049400.88186837
60Chronic myeloid leukemia_Homo sapiens_hsa052200.86814270
61Oocyte meiosis_Homo sapiens_hsa041140.83754689
62Systemic lupus erythematosus_Homo sapiens_hsa053220.83295952
63Thyroid cancer_Homo sapiens_hsa052160.83242646
64Propanoate metabolism_Homo sapiens_hsa006400.82154978
65Osteoclast differentiation_Homo sapiens_hsa043800.81602531
66Butanoate metabolism_Homo sapiens_hsa006500.81137048
67Influenza A_Homo sapiens_hsa051640.81050238
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80930369
69Colorectal cancer_Homo sapiens_hsa052100.80279012
70Shigellosis_Homo sapiens_hsa051310.80126196
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79139718
72Parkinsons disease_Homo sapiens_hsa050120.77767121
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76893837
74Allograft rejection_Homo sapiens_hsa053300.76315038
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75877475
76Pancreatic cancer_Homo sapiens_hsa052120.75151865
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.72848095
78TNF signaling pathway_Homo sapiens_hsa046680.72463459
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68959173
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67647883
81Toxoplasmosis_Homo sapiens_hsa051450.67633479
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65135016
83Oxidative phosphorylation_Homo sapiens_hsa001900.65026309
84Linoleic acid metabolism_Homo sapiens_hsa005910.64085730
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63128134
86Nicotine addiction_Homo sapiens_hsa050330.62879900
87Regulation of autophagy_Homo sapiens_hsa041400.60323755
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60215505
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59674889
90Viral myocarditis_Homo sapiens_hsa054160.59110902
91Ether lipid metabolism_Homo sapiens_hsa005650.58129610
92Taste transduction_Homo sapiens_hsa047420.57958932
93Notch signaling pathway_Homo sapiens_hsa043300.57340598
94Dorso-ventral axis formation_Homo sapiens_hsa043200.56613513
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56583408
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55617237
97Olfactory transduction_Homo sapiens_hsa047400.55369616
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.54913535
99N-Glycan biosynthesis_Homo sapiens_hsa005100.54627531
100Platelet activation_Homo sapiens_hsa046110.54546912
101TGF-beta signaling pathway_Homo sapiens_hsa043500.53748981
102Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53315396
103Huntingtons disease_Homo sapiens_hsa050160.52542825
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51761769
105Autoimmune thyroid disease_Homo sapiens_hsa053200.50181397
106Peroxisome_Homo sapiens_hsa041460.49580828
107Asthma_Homo sapiens_hsa053100.49036354
108Steroid biosynthesis_Homo sapiens_hsa001000.48354195
109Pathways in cancer_Homo sapiens_hsa052000.48209395
110FoxO signaling pathway_Homo sapiens_hsa040680.47864214
111Rheumatoid arthritis_Homo sapiens_hsa053230.47521473
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47152945
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44313965
114Non-small cell lung cancer_Homo sapiens_hsa052230.42839167
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41994537
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40529412
117Pentose phosphate pathway_Homo sapiens_hsa000300.40279546
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.39932703
119Chemokine signaling pathway_Homo sapiens_hsa040620.38804556
120Vitamin B6 metabolism_Homo sapiens_hsa007500.38483972
121Circadian rhythm_Homo sapiens_hsa047100.37288071
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.36531760
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36175054
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35541023
125Graft-versus-host disease_Homo sapiens_hsa053320.34321363
126Hepatitis C_Homo sapiens_hsa051600.32996237
127Prolactin signaling pathway_Homo sapiens_hsa049170.31979497
128Prostate cancer_Homo sapiens_hsa052150.31365155
129Pertussis_Homo sapiens_hsa051330.30787669
130Hippo signaling pathway_Homo sapiens_hsa043900.30347159
131HIF-1 signaling pathway_Homo sapiens_hsa040660.29085932
132Drug metabolism - other enzymes_Homo sapiens_hsa009830.28851381
133Tuberculosis_Homo sapiens_hsa051520.28043043
134mTOR signaling pathway_Homo sapiens_hsa041500.27318656
135Tryptophan metabolism_Homo sapiens_hsa003800.27244039
136Malaria_Homo sapiens_hsa051440.26965813
137Serotonergic synapse_Homo sapiens_hsa047260.24128964
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23876886
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23717425
140Long-term depression_Homo sapiens_hsa047300.22275389

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