GABARAPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.67738025
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.48851761
3glutamate secretion (GO:0014047)4.17969799
4synaptic vesicle exocytosis (GO:0016079)4.08295339
5locomotory exploration behavior (GO:0035641)4.06069871
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.05515763
7L-amino acid import (GO:0043092)3.96095484
8amino acid import (GO:0043090)3.83270526
9cerebellar granule cell differentiation (GO:0021707)3.82823788
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79654072
11neurotransmitter secretion (GO:0007269)3.74173866
12regulation of synaptic vesicle exocytosis (GO:2000300)3.73009919
13regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.70750567
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65787899
15L-phenylalanine catabolic process (GO:0006559)3.65787899
16vocalization behavior (GO:0071625)3.63166066
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.61484114
18neuronal ion channel clustering (GO:0045161)3.55519946
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.54547219
20L-phenylalanine metabolic process (GO:0006558)3.54547219
21regulation of synaptic vesicle transport (GO:1902803)3.43080974
22gamma-aminobutyric acid transport (GO:0015812)3.42759982
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.39418110
24regulation of glutamate receptor signaling pathway (GO:1900449)3.39201254
25regulation of ARF protein signal transduction (GO:0032012)3.37142545
26positive regulation of synapse maturation (GO:0090129)3.31365870
27regulation of neuronal synaptic plasticity (GO:0048168)3.29592694
28neuronal action potential propagation (GO:0019227)3.28541914
29cytoskeletal anchoring at plasma membrane (GO:0007016)3.24306906
30regulation of synapse structural plasticity (GO:0051823)3.24043419
31potassium ion import (GO:0010107)3.20340121
32regulation of voltage-gated calcium channel activity (GO:1901385)3.18474445
33potassium ion homeostasis (GO:0055075)3.18160159
34proline transport (GO:0015824)3.15989489
35exploration behavior (GO:0035640)3.14914882
36glutamate metabolic process (GO:0006536)3.13959961
37regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12889396
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.12315140
39aromatic amino acid family catabolic process (GO:0009074)3.09545029
40neurotransmitter-gated ion channel clustering (GO:0072578)3.09358275
41cell communication involved in cardiac conduction (GO:0086065)3.07426091
42cellular potassium ion homeostasis (GO:0030007)3.07416398
43lysine catabolic process (GO:0006554)3.06949582
44lysine metabolic process (GO:0006553)3.06949582
45activation of protein kinase A activity (GO:0034199)3.06929322
46protein localization to synapse (GO:0035418)3.06118194
47neurotransmitter transport (GO:0006836)3.06036130
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02003199
49dicarboxylic acid biosynthetic process (GO:0043650)3.01934347
50neuromuscular process controlling posture (GO:0050884)3.01803281
51sodium ion export (GO:0071436)2.98152909
52positive regulation of neurotransmitter secretion (GO:0001956)2.97386150
53regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.96441448
54regulation of neurotransmitter levels (GO:0001505)2.94655668
55detection of calcium ion (GO:0005513)2.94463208
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93092812
57synaptic vesicle endocytosis (GO:0048488)2.92549870
58ionotropic glutamate receptor signaling pathway (GO:0035235)2.91122166
59regulation of cell communication by electrical coupling (GO:0010649)2.90077016
60layer formation in cerebral cortex (GO:0021819)2.88962417
61positive regulation of dendritic spine development (GO:0060999)2.88717432
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.87808752
63regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.85299101
64gamma-aminobutyric acid signaling pathway (GO:0007214)2.81042256
65bile acid biosynthetic process (GO:0006699)2.79795293
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79367970
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.79049399
68negative regulation of dendrite morphogenesis (GO:0050774)2.77831326
69cellular ketone body metabolic process (GO:0046950)2.77197808
70cysteine metabolic process (GO:0006534)2.76856053
71cerebellar Purkinje cell differentiation (GO:0021702)2.74982976
72postsynaptic membrane organization (GO:0001941)2.74192791
73regulation of neurotransmitter transport (GO:0051588)2.72964343
74regulation of synapse maturation (GO:0090128)2.72041638
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71713558
76alpha-linolenic acid metabolic process (GO:0036109)2.71638366
77dicarboxylic acid catabolic process (GO:0043649)2.70283108
78kynurenine metabolic process (GO:0070189)2.69592982
79glycine transport (GO:0015816)2.67347333
80peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.67289201
81glyoxylate metabolic process (GO:0046487)2.66681947
82positive regulation of membrane potential (GO:0045838)2.66102251
83positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65483343
84cell communication by electrical coupling (GO:0010644)2.64477214
85drug catabolic process (GO:0042737)2.64376452
86alanine transport (GO:0032328)2.63770344
87negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63111648
88membrane depolarization during action potential (GO:0086010)2.62657608
89exogenous drug catabolic process (GO:0042738)2.61977989
90cellular response to catecholamine stimulus (GO:0071870)2.61753592
91cellular response to monoamine stimulus (GO:0071868)2.61753592
92positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.61283016
93synaptic transmission, glutamatergic (GO:0035249)2.61210198
94aspartate family amino acid catabolic process (GO:0009068)2.59818642
95acidic amino acid transport (GO:0015800)2.59590631
96neuron-neuron synaptic transmission (GO:0007270)2.59110548
97neuron cell-cell adhesion (GO:0007158)2.58658163
98tryptophan catabolic process (GO:0006569)2.58621134
99indole-containing compound catabolic process (GO:0042436)2.58621134
100indolalkylamine catabolic process (GO:0046218)2.58621134
101prepulse inhibition (GO:0060134)2.56126833
102positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55742022
103cellular modified amino acid catabolic process (GO:0042219)2.55602344
104drug transmembrane transport (GO:0006855)2.55589133
105regulation of excitatory postsynaptic membrane potential (GO:0060079)2.54439586
106neuromuscular process controlling balance (GO:0050885)2.53284484
107regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.52505062
108long-term memory (GO:0007616)2.52175690
109regulation of synaptic plasticity (GO:0048167)2.50613209
110behavioral response to cocaine (GO:0048148)2.49103945
111cellular response to epinephrine stimulus (GO:0071872)2.48924298
112cellular sodium ion homeostasis (GO:0006883)2.47532963
113short-chain fatty acid metabolic process (GO:0046459)2.47196090
114glutamate receptor signaling pathway (GO:0007215)2.46659649
115regulation of synaptic transmission (GO:0050804)2.45236938
116triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.45133129
117mating behavior (GO:0007617)2.43995113
118dendritic spine organization (GO:0097061)2.43352933
119sulfur amino acid catabolic process (GO:0000098)2.43235109
120clathrin coat assembly (GO:0048268)2.41827542
121succinate metabolic process (GO:0006105)2.41719391
122membrane depolarization (GO:0051899)2.41006271
123regulation of postsynaptic membrane potential (GO:0060078)2.40952328
124regulation of female receptivity (GO:0045924)2.40224990
125cardiac muscle contraction (GO:0060048)2.39763472
126ketone body metabolic process (GO:1902224)2.39723766
127regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39632163
128tryptophan metabolic process (GO:0006568)2.39020530
129fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.37276438
130regulation of dendritic spine development (GO:0060998)2.36946535
131regulation of neurotransmitter secretion (GO:0046928)2.36068382
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.35695144
133axon ensheathment in central nervous system (GO:0032291)2.35345768
134central nervous system myelination (GO:0022010)2.35345768
135regulation of synaptic transmission, glutamatergic (GO:0051966)2.34379206
136neuromuscular process (GO:0050905)2.34324166
137coenzyme catabolic process (GO:0009109)2.32897156
138regulation of vesicle fusion (GO:0031338)2.32686787
139regulation of dendritic spine morphogenesis (GO:0061001)2.32195441
140positive regulation of neurotransmitter transport (GO:0051590)2.30810139
141dendritic spine morphogenesis (GO:0060997)2.30452460
142long-term synaptic potentiation (GO:0060291)2.29919067
143alpha-amino acid catabolic process (GO:1901606)2.28451003
144bile acid metabolic process (GO:0008206)2.27118267
1452-oxoglutarate metabolic process (GO:0006103)2.27065976
146cellular amino acid catabolic process (GO:0009063)2.26888824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91634945
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.49356260
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61246349
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58299824
5GBX2_23144817_ChIP-Seq_PC3_Human2.50253642
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.48907524
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.31729167
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.30111622
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29869120
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29472762
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25541028
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25541028
13REST_21632747_ChIP-Seq_MESCs_Mouse2.24273798
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.22073479
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16726519
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.12734005
17DROSHA_22980978_ChIP-Seq_HELA_Human2.12251269
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07002717
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.05313965
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.99893908
21REST_18959480_ChIP-ChIP_MESCs_Mouse1.98752058
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.94778196
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94437329
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.90225704
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.88207396
26ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.80281476
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.78371935
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77362681
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.76347962
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.74908820
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.61377437
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59318137
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.58692110
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58387669
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.58058961
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56525355
37* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53106797
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53072280
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48535230
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48371416
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41436468
42SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36593955
43TAF15_26573619_Chip-Seq_HEK293_Human1.35928932
44AR_21572438_ChIP-Seq_LNCaP_Human1.33361974
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.30192501
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28461898
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28387865
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.28353352
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28231032
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28230923
51SMAD4_21799915_ChIP-Seq_A2780_Human1.23476617
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23246438
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19781787
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19742487
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18551546
56KDM2B_26808549_Chip-Seq_DND41_Human1.16091736
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10798812
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10688967
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09787415
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07900344
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.07806458
62CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07582503
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07207274
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05854734
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.05310176
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.04863827
67CLOCK_20551151_ChIP-Seq_293T_Human1.03386211
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03251425
69KDM2B_26808549_Chip-Seq_K562_Human1.03194448
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02959915
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02358225
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.02314193
73TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01622366
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01058264
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01022074
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00992251
77AR_25329375_ChIP-Seq_VCAP_Human1.00535944
78SMC4_20622854_ChIP-Seq_HELA_Human1.00449119
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99733326
80ZNF274_21170338_ChIP-Seq_K562_Hela0.99607593
81PIAS1_25552417_ChIP-Seq_VCAP_Human0.98766510
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.98419852
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98415998
84CTCF_27219007_Chip-Seq_Bcells_Human0.98371716
85AR_19668381_ChIP-Seq_PC3_Human0.96424733
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.96413172
87TBX20_22328084_ChIP-Seq_HEART_Mouse0.96413172
88TP53_20018659_ChIP-ChIP_R1E_Mouse0.95670060
89NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95004019
90* KDM2B_26808549_Chip-Seq_JURKAT_Human0.93688091
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93462403
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92768029
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92370044
94FOXA2_19822575_ChIP-Seq_HepG2_Human0.92100104
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.91750676
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91618794
97RING1B_27294783_Chip-Seq_NPCs_Mouse0.91227853
98TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.89925472
99P300_19829295_ChIP-Seq_ESCs_Human0.89679262
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88820197
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87380422
102* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86865771
103* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86487704
104LXR_22292898_ChIP-Seq_THP-1_Human0.86466348
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86352881
106CREB1_26743006_Chip-Seq_LNCaP_Human0.85873993
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85599168
108TET1_21490601_ChIP-Seq_MESCs_Mouse0.85339458
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.84910016
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84372131
111AHR_22903824_ChIP-Seq_MCF-7_Human0.84091967
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83106915
113TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82985407
114STAT3_23295773_ChIP-Seq_U87_Human0.82627466
115BCAT_22108803_ChIP-Seq_LS180_Human0.82579735
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82086219
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81940728
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81652726
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.81641084
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81516425
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.81485575
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80530008
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80246308
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.80097136
125KLF4_19829295_ChIP-Seq_ESCs_Human0.79463113
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79140485
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79057527
128MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78752445
129SMAD3_21741376_ChIP-Seq_EPCs_Human0.78488251
130RXR_22108803_ChIP-Seq_LS180_Human0.78408325
131SMAD4_21741376_ChIP-Seq_EPCs_Human0.77646053
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.77571078
133OCT4_19829295_ChIP-Seq_ESCs_Human0.76769903
134DPY_21335234_ChIP-Seq_ESCs_Mouse0.75871900
135* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75848282
136* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75848282
137RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.75491897
138GATA1_26923725_Chip-Seq_HPCs_Mouse0.74956839
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74446295
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.73515329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.06533218
2MP0002139_abnormal_hepatobiliary_system3.84034018
3MP0005360_urolithiasis3.47856413
4MP0002822_catalepsy3.22966253
5MP0003880_abnormal_central_pattern3.20546843
6MP0003635_abnormal_synaptic_transmissio3.16411652
7MP0004270_analgesia2.92196572
8MP0005085_abnormal_gallbladder_physiolo2.79172942
9MP0009745_abnormal_behavioral_response2.66695190
10MP0008875_abnormal_xenobiotic_pharmacok2.55491957
11MP0005365_abnormal_bile_salt2.53154022
12MP0002063_abnormal_learning/memory/cond2.51963536
13MP0002064_seizures2.51528463
14MP0001968_abnormal_touch/_nociception2.40691279
15MP0009046_muscle_twitch2.32853711
16MP0003329_amyloid_beta_deposits2.14870593
17MP0002572_abnormal_emotion/affect_behav2.06826188
18MP0002272_abnormal_nervous_system2.00528534
19MP0001501_abnormal_sleep_pattern2.00228387
20MP0002734_abnormal_mechanical_nocicepti1.94615989
21MP0003195_calcinosis1.91044141
22MP0002909_abnormal_adrenal_gland1.90859399
23MP0002735_abnormal_chemical_nociception1.86489058
24MP0002736_abnormal_nociception_after1.85638881
25MP0004510_myositis1.84315238
26MP0001486_abnormal_startle_reflex1.83686245
27MP0004858_abnormal_nervous_system1.82510128
28MP0009780_abnormal_chondrocyte_physiolo1.81205597
29MP0005332_abnormal_amino_acid1.76357813
30MP0002733_abnormal_thermal_nociception1.74559580
31MP0010329_abnormal_lipoprotein_level1.71959680
32MP0004043_abnormal_pH_regulation1.68778186
33MP0005423_abnormal_somatic_nervous1.67987311
34MP0003252_abnormal_bile_duct1.63285689
35MP0001440_abnormal_grooming_behavior1.61359926
36MP0006276_abnormal_autonomic_nervous1.56765015
37MP0001970_abnormal_pain_threshold1.54041677
38MP0005646_abnormal_pituitary_gland1.52744774
39MP0005535_abnormal_body_temperature1.50280534
40MP0002067_abnormal_sensory_capabilities1.43691709
41MP0000749_muscle_degeneration1.41272632
42MP0000604_amyloidosis1.39710452
43MP0003879_abnormal_hair_cell1.34377030
44MP0003633_abnormal_nervous_system1.34305879
45MP0005386_behavior/neurological_phenoty1.34172540
46MP0004924_abnormal_behavior1.34172540
47MP0004885_abnormal_endolymph1.34070791
48MP0004036_abnormal_muscle_relaxation1.33669067
49MP0008569_lethality_at_weaning1.31586442
50MP0005083_abnormal_biliary_tract1.30956505
51MP0004811_abnormal_neuron_physiology1.29917853
52MP0001984_abnormal_olfaction1.28436628
53MP0003075_altered_response_to1.23607402
54MP0004084_abnormal_cardiac_muscle1.23432028
55MP0003634_abnormal_glial_cell1.22463225
56MP0005584_abnormal_enzyme/coenzyme_acti1.20811590
57MP0004019_abnormal_vitamin_homeostasis1.20442920
58MP0008872_abnormal_physiological_respon1.19647133
59MP0002557_abnormal_social/conspecific_i1.19482818
60MP0004484_altered_response_of1.18703324
61MP0002118_abnormal_lipid_homeostasis1.18475496
62MP0002837_dystrophic_cardiac_calcinosis1.18373427
63MP0008961_abnormal_basal_metabolism1.16565896
64MP0008874_decreased_physiological_sensi1.15482253
65MP0003690_abnormal_glial_cell1.15073815
66MP0001348_abnormal_lacrimal_gland1.14026263
67MP0001958_emphysema1.11729931
68MP0001765_abnormal_ion_homeostasis1.10740070
69MP0000747_muscle_weakness1.10312558
70MP0002066_abnormal_motor_capabilities/c1.09996976
71MP0000013_abnormal_adipose_tissue1.09695217
72MP0004130_abnormal_muscle_cell1.09519632
73MP0000955_abnormal_spinal_cord1.07672687
74MP0005623_abnormal_meninges_morphology1.05244981
75MP0002184_abnormal_innervation1.04468600
76MP0002295_abnormal_pulmonary_circulatio1.04277212
77MP0001502_abnormal_circadian_rhythm1.03560536
78MP0002876_abnormal_thyroid_physiology1.03161095
79MP0003631_nervous_system_phenotype1.03014507
80MP0003705_abnormal_hypodermis_morpholog1.00857794
81MP0004215_abnormal_myocardial_fiber1.00726581
82MP0004087_abnormal_muscle_fiber1.00537887
83MP0008260_abnormal_autophagy0.99125031
84MP0004142_abnormal_muscle_tone0.98455289
85MP0005058_abnormal_lysosome_morphology0.97366180
86MP0008438_abnormal_cutaneous_collagen0.96542237
87MP0001666_abnormal_nutrient_absorption0.96204485
88MP0005167_abnormal_blood-brain_barrier0.95963696
89MP0002069_abnormal_eating/drinking_beha0.95440037
90MP0001905_abnormal_dopamine_level0.95369749
91MP0009840_abnormal_foam_cell0.95014452
92MP0006138_congestive_heart_failure0.92359771
93MP0003191_abnormal_cellular_cholesterol0.92326346
94MP0002972_abnormal_cardiac_muscle0.92163804
95MP0003279_aneurysm0.91985326
96MP0003632_abnormal_nervous_system0.91855748
97MP0002882_abnormal_neuron_morphology0.89766841
98MP0002229_neurodegeneration0.89629344
99MP0005620_abnormal_muscle_contractility0.88418017
100MP0000759_abnormal_skeletal_muscle0.86833784
101MP0002090_abnormal_vision0.86160707
102MP0005166_decreased_susceptibility_to0.85763419
103MP0001756_abnormal_urination0.83853431
104MP0003828_pulmonary_edema0.83135970
105MP0010386_abnormal_urinary_bladder0.82726434
106MP0005636_abnormal_mineral_homeostasis0.82579189
107MP0003122_maternal_imprinting0.82328404
108MP0002138_abnormal_hepatobiliary_system0.82109583
109MP0008004_abnormal_stomach_pH0.81202731
110MP0002078_abnormal_glucose_homeostasis0.80792744
111MP0000750_abnormal_muscle_regeneration0.79870053
112MP0000751_myopathy0.79366644
113MP0000343_altered_response_to0.79240905
114MP0003868_abnormal_feces_composition0.78816768
115MP0005670_abnormal_white_adipose0.78771217
116MP0000778_abnormal_nervous_system0.78688226
117MP0002332_abnormal_exercise_endurance0.78211526
118MP0003137_abnormal_impulse_conducting0.77401187
119MP0003787_abnormal_imprinting0.77146860
120MP0009643_abnormal_urine_homeostasis0.76873679
121MP0000230_abnormal_systemic_arterial0.76555367
122MP0005645_abnormal_hypothalamus_physiol0.75484021
123MP0002269_muscular_atrophy0.75243000
124MP0005319_abnormal_enzyme/_coenzyme0.75234394
125MP0003806_abnormal_nucleotide_metabolis0.74429536
126MP0001177_atelectasis0.72808146
127MP0003091_abnormal_cell_migration0.72529451
128MP0001529_abnormal_vocalization0.72005644
129MP0003172_abnormal_lysosome_physiology0.71461248
130MP0005409_darkened_coat_color0.71371330
131MP0005595_abnormal_vascular_smooth0.71166480
132MP0002152_abnormal_brain_morphology0.70370813
133MP0005388_respiratory_system_phenotype0.69617242
134MP0002133_abnormal_respiratory_system0.69617242
135MP0003283_abnormal_digestive_organ0.68334684
136MP0002971_abnormal_brown_adipose0.67982702
137MP0005551_abnormal_eye_electrophysiolog0.67319734
138MP0000920_abnormal_myelination0.66624143
139MP0003953_abnormal_hormone_level0.66580902
140MP0004085_abnormal_heartbeat0.66260183
141MP0005084_abnormal_gallbladder_morpholo0.65597723

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.66056804
2Focal motor seizures (HP:0011153)5.01222302
3Visual hallucinations (HP:0002367)3.87563232
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.85748645
5Focal seizures (HP:0007359)3.84769029
6Diplopia (HP:0000651)3.63611849
7Abnormality of binocular vision (HP:0011514)3.63611849
8Gout (HP:0001997)3.44029502
9Deep venous thrombosis (HP:0002625)3.23126172
10Action tremor (HP:0002345)3.10311084
11Bundle branch block (HP:0011710)3.09068915
12Obstructive sleep apnea (HP:0002870)3.06238616
13Increased circulating renin level (HP:0000848)3.01839676
14Ketosis (HP:0001946)2.98536152
15Supranuclear gaze palsy (HP:0000605)2.93693336
16Generalized tonic-clonic seizures (HP:0002069)2.93046298
17Hyporeflexia of lower limbs (HP:0002600)2.93025294
18Xanthomatosis (HP:0000991)2.92597861
19Atonic seizures (HP:0010819)2.91184397
20Ketoacidosis (HP:0001993)2.85751153
21Absence seizures (HP:0002121)2.85108767
22Torticollis (HP:0000473)2.83680250
23Epileptic encephalopathy (HP:0200134)2.79126933
24Anxiety (HP:0000739)2.78223910
25Intrahepatic cholestasis (HP:0001406)2.78087566
26Status epilepticus (HP:0002133)2.75012696
27Neuronal loss in central nervous system (HP:0002529)2.74875326
28Hyperventilation (HP:0002883)2.73582062
29Abnormal eating behavior (HP:0100738)2.72193163
30Sudden death (HP:0001699)2.71503503
31Focal dystonia (HP:0004373)2.71466614
32Febrile seizures (HP:0002373)2.66574295
33Pheochromocytoma (HP:0002666)2.64171974
34Muscle fiber splitting (HP:0003555)2.64037303
35Abnormality of glutamine family amino acid metabolism (HP:0010902)2.63849956
36Craniofacial dystonia (HP:0012179)2.63632778
37Postural instability (HP:0002172)2.60708258
38Depression (HP:0000716)2.60306885
39Progressive cerebellar ataxia (HP:0002073)2.60042917
40Ankle clonus (HP:0011448)2.58950432
41Rapidly progressive (HP:0003678)2.55660870
42Dialeptic seizures (HP:0011146)2.54037278
43Impaired social interactions (HP:0000735)2.53739288
44Abnormal social behavior (HP:0012433)2.53739288
45Annular pancreas (HP:0001734)2.53614873
46Hypokalemic alkalosis (HP:0001949)2.51256931
47Foot dorsiflexor weakness (HP:0009027)2.50638671
48Hyperlipoproteinemia (HP:0010980)2.50150077
49Impaired vibration sensation in the lower limbs (HP:0002166)2.48861154
50Poor eye contact (HP:0000817)2.48724000
51Lower limb muscle weakness (HP:0007340)2.47942506
52Lower limb amyotrophy (HP:0007210)2.46683399
53Apathy (HP:0000741)2.46405438
54Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46285770
55Abnormality of the lower motor neuron (HP:0002366)2.43841199
56Heart block (HP:0012722)2.42451261
57Increased variability in muscle fiber diameter (HP:0003557)2.40303905
58Abnormality of the foot musculature (HP:0001436)2.39235510
59Neurofibrillary tangles (HP:0002185)2.38960256
60Abnormal atrioventricular conduction (HP:0005150)2.38810762
61Hyperammonemia (HP:0001987)2.38025096
62Metabolic alkalosis (HP:0200114)2.37448361
63Neonatal onset (HP:0003623)2.37225878
64Hyperglycinuria (HP:0003108)2.34403249
65Complement deficiency (HP:0004431)2.32011920
66Peripheral hypomyelination (HP:0007182)2.30427993
67Alkalosis (HP:0001948)2.30401975
68Asymmetric septal hypertrophy (HP:0001670)2.29588187
69Cerebral inclusion bodies (HP:0100314)2.28588998
70Hyperglycinemia (HP:0002154)2.27636747
71Neuroendocrine neoplasm (HP:0100634)2.27295179
72Diminished motivation (HP:0000745)2.24558031
73Dysdiadochokinesis (HP:0002075)2.24237875
74Sensorimotor neuropathy (HP:0007141)2.24206066
75Abnormality of serine family amino acid metabolism (HP:0010894)2.23909408
76Abnormality of glycine metabolism (HP:0010895)2.23909408
77Delayed CNS myelination (HP:0002188)2.21612048
78Atrioventricular block (HP:0001678)2.20608277
79Abnormal gallbladder physiology (HP:0012438)2.19999683
80Cholecystitis (HP:0001082)2.19999683
81Intention tremor (HP:0002080)2.18692965
82Dysmetria (HP:0001310)2.17890431
83Hyperactive renin-angiotensin system (HP:0000841)2.15890125
84EMG: myopathic abnormalities (HP:0003458)2.11327609
85Prolonged partial thromboplastin time (HP:0003645)2.10198349
86Abnormality of purine metabolism (HP:0004352)2.08417940
87Difficulty running (HP:0009046)2.08174576
88Bradykinesia (HP:0002067)2.07434866
89Urinary bladder sphincter dysfunction (HP:0002839)2.07196353
90Hypobetalipoproteinemia (HP:0003563)2.05064741
91Atrial fibrillation (HP:0005110)2.04802892
92Urinary urgency (HP:0000012)2.03923921
93Primary atrial arrhythmia (HP:0001692)2.02199507
94Scanning speech (HP:0002168)2.02057249
95Clonus (HP:0002169)2.01600695
96Type 1 muscle fiber predominance (HP:0003803)2.01312759
97Protrusio acetabuli (HP:0003179)2.01240129
98Truncal ataxia (HP:0002078)2.01191145
99Distal upper limb amyotrophy (HP:0007149)2.01180775
100Upper limb amyotrophy (HP:0009129)2.01180775
101Abnormality of skeletal muscle fiber size (HP:0012084)2.00905067
102Exercise-induced myalgia (HP:0003738)2.00436529
103Increased purine levels (HP:0004368)1.95730327
104Hyperuricemia (HP:0002149)1.95730327
105Papilledema (HP:0001085)1.95207048
106Polyphagia (HP:0002591)1.94471728
107Syncope (HP:0001279)1.94087273
108Slow progression (HP:0003677)1.94063942
109Delusions (HP:0000746)1.93502438
110Supraventricular tachycardia (HP:0004755)1.93378160
111Hypomagnesemia (HP:0002917)1.93115195
112Distal lower limb amyotrophy (HP:0008944)1.92543781
113Spastic gait (HP:0002064)1.91615692
114Epidermoid cyst (HP:0200040)1.91389507
115Agitation (HP:0000713)1.91378761
116Slow saccadic eye movements (HP:0000514)1.90929955
117Supraventricular arrhythmia (HP:0005115)1.90760865
118Cerebral hypomyelination (HP:0006808)1.90494920
119Hypercortisolism (HP:0001578)1.89785269
120Decreased motor nerve conduction velocity (HP:0003431)1.89766848
121Abnormality of the corticospinal tract (HP:0002492)1.89688292
122Hammertoe (HP:0001765)1.88641067
123Mutism (HP:0002300)1.88336410
124Ventricular fibrillation (HP:0001663)1.87372606
125Progressive inability to walk (HP:0002505)1.87203878
126Amblyopia (HP:0000646)1.86909446
127Impaired vibratory sensation (HP:0002495)1.85802630
128Scapular winging (HP:0003691)1.84814971
129Epileptiform EEG discharges (HP:0011182)1.84451823
130EEG with generalized epileptiform discharges (HP:0011198)1.83889582
131Sleep apnea (HP:0010535)1.83692407
132Turricephaly (HP:0000262)1.83530057
133Hypsarrhythmia (HP:0002521)1.82615359
134Centrally nucleated skeletal muscle fibers (HP:0003687)1.82449894
135Amyloidosis (HP:0011034)1.82398544
136Abnormality of magnesium homeostasis (HP:0004921)1.82374923
137Distal lower limb muscle weakness (HP:0009053)1.82164194
138Hand muscle atrophy (HP:0009130)1.81504628
139Aortic aneurysm (HP:0004942)1.81291799
140Gaze-evoked nystagmus (HP:0000640)1.80593429
141Resting tremor (HP:0002322)1.80294519
142Frequent falls (HP:0002359)1.80069687
143Rigidity (HP:0002063)1.79243986
144Tetraplegia (HP:0002445)1.79156177
145Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77663702
146Limb dystonia (HP:0002451)1.77618765
147Abnormal urine output (HP:0012590)1.77379114
148Irritability (HP:0000737)1.77350269
149Dysmetric saccades (HP:0000641)1.77119307
150Cerebral hemorrhage (HP:0001342)1.76727460
151Global brain atrophy (HP:0002283)1.76146050
152Broad-based gait (HP:0002136)1.76057080
153Hyperaldosteronism (HP:0000859)1.75750066
154Hemiplegia (HP:0002301)1.75629256

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.82492714
2EPHA43.79708980
3MAP3K93.52569858
4DAPK22.62005508
5MAP3K42.58178861
6MINK12.56507440
7KSR22.52800859
8MAP2K42.39114325
9NTRK12.19202384
10MAP3K122.08820185
11MAP2K72.05487179
12PRKD31.95763830
13PAK61.93716470
14CAMKK11.91372579
15ARAF1.88658609
16WNK41.85793208
17MARK11.76732896
18WNK31.76296949
19OXSR11.76112373
20MAP3K21.57590825
21PINK11.54595392
22GRK51.50224754
23STK381.46151942
24MAP3K131.43588459
25MYLK1.42097770
26RIPK41.40217623
27NTRK21.38012168
28DAPK11.33557606
29CDK51.33101113
30SGK2231.29547953
31SGK4941.29547953
32KSR11.20436897
33LMTK21.19163028
34TTN1.18543759
35BCKDK1.16988706
36CAMKK21.12937678
37RET1.11935586
38PRKCG1.11483318
39CDK191.10763772
40TESK11.06733402
41MAP3K11.06491169
42PRKCH1.01252490
43FES0.97675180
44SGK30.96456970
45TAOK10.95269088
46SGK20.95132755
47OBSCN0.94749501
48TRIB30.94143200
49NEK60.94122807
50LATS20.92967882
51PHKG20.92352299
52PHKG10.92352299
53PDPK10.90704785
54PDGFRA0.90079395
55PDK20.88657525
56PAK30.85714508
57NEK10.85599907
58MOS0.84362675
59SIK20.83121582
60PTK2B0.82924799
61PDK10.81975918
62CAMK10.81876999
63CAMK2A0.79957318
64UHMK10.78098785
65DYRK1A0.78043618
66MAP2K10.77371185
67STK390.76962298
68TYRO30.74381237
69RIPK10.72590379
70MAP3K70.71341286
71PLK20.70939885
72DDR20.70534002
73AKT30.69314092
74PRKCZ0.69192192
75FER0.68781370
76LIMK10.68551220
77RAF10.67677977
78DMPK0.66929444
79PRPF4B0.66733549
80STK110.64587254
81WNK10.64263013
82TNIK0.62947618
83CAMK2G0.62889364
84MAPK130.62277667
85ROCK20.61836415
86DYRK1B0.61752019
87PDK30.60936888
88PDK40.60936888
89TNK20.60408434
90CDK140.59993373
91CASK0.59196484
92CSNK1G20.57985381
93CDK180.57365634
94MAP3K60.57355248
95MAPK70.57312874
96INSRR0.57233497
97CDK150.56716656
98SGK10.56504360
99MAPK100.56443477
100PRKG20.54918399
101CAMK2B0.54378362
102BRAF0.51699233
103RPS6KA20.51696980
104EPHB10.50041299
105SCYL20.49714855
106MAP3K50.49082217
107DAPK30.47231252
108CAMK40.46857286
109CDK11A0.46549213
110PRKD10.45796696
111IRAK20.45650027
112PKN10.44310167
113BMPR20.44147257
114MARK20.43860543
115RPS6KA30.43208493
116CAMK1G0.42808046
117FYN0.42374250
118PRKACG0.41848853
119TAOK20.41833444
120ICK0.41814227
121PRKCE0.40378963
122MAPK120.38269826
123CAMK2D0.37437847
124MAP3K110.36087855
125SIK10.35993711
126MAP2K60.35523653
127ALK0.34972302
128FGFR40.34141524
129JAK20.33445648
130ERN10.32827015

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.38454811
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71374183
3Synaptic vesicle cycle_Homo sapiens_hsa047212.55910044
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.35286453
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.18559514
6Arginine biosynthesis_Homo sapiens_hsa002202.09219084
7Nicotine addiction_Homo sapiens_hsa050331.96986720
8Butanoate metabolism_Homo sapiens_hsa006501.94710351
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90625999
10Olfactory transduction_Homo sapiens_hsa047401.74958225
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73712628
12* GABAergic synapse_Homo sapiens_hsa047271.70784695
13Bile secretion_Homo sapiens_hsa049761.59750198
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.59645492
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.55734259
16Circadian entrainment_Homo sapiens_hsa047131.54544473
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54078973
18Amphetamine addiction_Homo sapiens_hsa050311.47191040
19Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46570240
20Long-term potentiation_Homo sapiens_hsa047201.41376901
21Tryptophan metabolism_Homo sapiens_hsa003801.40794112
22Glutamatergic synapse_Homo sapiens_hsa047241.40365668
23Collecting duct acid secretion_Homo sapiens_hsa049661.40168752
24Insulin secretion_Homo sapiens_hsa049111.40014329
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39489992
26Morphine addiction_Homo sapiens_hsa050321.38666262
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37049068
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.31862574
29Fatty acid degradation_Homo sapiens_hsa000711.31576987
30Dilated cardiomyopathy_Homo sapiens_hsa054141.31471403
31Propanoate metabolism_Homo sapiens_hsa006401.30998670
32Salivary secretion_Homo sapiens_hsa049701.30681951
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29382826
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28353246
35Dopaminergic synapse_Homo sapiens_hsa047281.26456154
36Gastric acid secretion_Homo sapiens_hsa049711.24022958
37Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15093108
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12039920
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11614585
40Cocaine addiction_Homo sapiens_hsa050301.10098768
41Cholinergic synapse_Homo sapiens_hsa047251.08138742
42PPAR signaling pathway_Homo sapiens_hsa033201.06096154
43Fatty acid metabolism_Homo sapiens_hsa012121.05548345
44Pyruvate metabolism_Homo sapiens_hsa006201.05254065
45Peroxisome_Homo sapiens_hsa041461.01547911
46Renin secretion_Homo sapiens_hsa049240.99476289
47Phospholipase D signaling pathway_Homo sapiens_hsa040720.96167460
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95116110
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95066744
50Taste transduction_Homo sapiens_hsa047420.94341301
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.92802648
52Circadian rhythm_Homo sapiens_hsa047100.92609193
53beta-Alanine metabolism_Homo sapiens_hsa004100.91726114
54Phenylalanine metabolism_Homo sapiens_hsa003600.90329142
55Complement and coagulation cascades_Homo sapiens_hsa046100.89010770
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85712236
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84810921
58ErbB signaling pathway_Homo sapiens_hsa040120.81911606
59Oxytocin signaling pathway_Homo sapiens_hsa049210.81373981
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.79792295
61Calcium signaling pathway_Homo sapiens_hsa040200.79327835
62Serotonergic synapse_Homo sapiens_hsa047260.78233154
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76222127
64VEGF signaling pathway_Homo sapiens_hsa043700.76081799
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75357358
66GnRH signaling pathway_Homo sapiens_hsa049120.72843800
67Type II diabetes mellitus_Homo sapiens_hsa049300.72810386
68MAPK signaling pathway_Homo sapiens_hsa040100.72150128
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.70736522
70Endocytosis_Homo sapiens_hsa041440.70464865
71Long-term depression_Homo sapiens_hsa047300.70373918
72Rap1 signaling pathway_Homo sapiens_hsa040150.70236392
73Carbon metabolism_Homo sapiens_hsa012000.68809040
74Starch and sucrose metabolism_Homo sapiens_hsa005000.67681630
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67660790
76Gap junction_Homo sapiens_hsa045400.66885450
77Axon guidance_Homo sapiens_hsa043600.66485332
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66287060
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65923214
80cAMP signaling pathway_Homo sapiens_hsa040240.65579250
81Histidine metabolism_Homo sapiens_hsa003400.64850987
82Sulfur metabolism_Homo sapiens_hsa009200.64700598
83Vibrio cholerae infection_Homo sapiens_hsa051100.64109567
84Thyroid hormone synthesis_Homo sapiens_hsa049180.63671590
85Ras signaling pathway_Homo sapiens_hsa040140.62045774
86Inositol phosphate metabolism_Homo sapiens_hsa005620.61941158
87Chemical carcinogenesis_Homo sapiens_hsa052040.61666696
88Amoebiasis_Homo sapiens_hsa051460.61233919
89Tyrosine metabolism_Homo sapiens_hsa003500.61181239
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.61072756
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60958211
92Glucagon signaling pathway_Homo sapiens_hsa049220.60691296
93AMPK signaling pathway_Homo sapiens_hsa041520.60656404
94Vitamin B6 metabolism_Homo sapiens_hsa007500.60391039
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.59976593
96Prion diseases_Homo sapiens_hsa050200.59423401
97Glycerolipid metabolism_Homo sapiens_hsa005610.58696207
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.58468147
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57655583
100Biosynthesis of amino acids_Homo sapiens_hsa012300.56840735
101Mineral absorption_Homo sapiens_hsa049780.54985689
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54768860
103Choline metabolism in cancer_Homo sapiens_hsa052310.54559705
104Glioma_Homo sapiens_hsa052140.54479647
105Focal adhesion_Homo sapiens_hsa045100.54226985
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54102101
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53480924
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53411273
109Estrogen signaling pathway_Homo sapiens_hsa049150.52544192
110Cardiac muscle contraction_Homo sapiens_hsa042600.51387457
111ABC transporters_Homo sapiens_hsa020100.49342341
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47888336
113Renal cell carcinoma_Homo sapiens_hsa052110.47438138
114Ovarian steroidogenesis_Homo sapiens_hsa049130.47169152
115Arginine and proline metabolism_Homo sapiens_hsa003300.47147373
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.46786573
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46073019
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45639376
119Caffeine metabolism_Homo sapiens_hsa002320.45342855
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45247431
121mTOR signaling pathway_Homo sapiens_hsa041500.44193370
122cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43410488
123Lysosome_Homo sapiens_hsa041420.42581413
124Pancreatic secretion_Homo sapiens_hsa049720.42338461
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42148962
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42139913
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41745131
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.41459466
129Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39709507
130HIF-1 signaling pathway_Homo sapiens_hsa040660.39560417
131Protein digestion and absorption_Homo sapiens_hsa049740.39445754
132ECM-receptor interaction_Homo sapiens_hsa045120.39362769
133Fatty acid biosynthesis_Homo sapiens_hsa000610.38958055
134Dorso-ventral axis formation_Homo sapiens_hsa043200.37253551
135Melanogenesis_Homo sapiens_hsa049160.36873532
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.36720776
137Fatty acid elongation_Homo sapiens_hsa000620.36658402
138Retinol metabolism_Homo sapiens_hsa008300.36439196
139Insulin signaling pathway_Homo sapiens_hsa049100.35859128

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