GABARAP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)4.54121257
2Golgi transport vesicle coating (GO:0048200)4.54121257
3neutrophil activation involved in immune response (GO:0002283)4.12426332
4signal peptide processing (GO:0006465)3.93719157
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.90260056
6ATP synthesis coupled proton transport (GO:0015986)3.80703385
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80703385
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.69632393
9ATP hydrolysis coupled proton transport (GO:0015991)3.62205611
10energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.62205611
11protein retention in ER lumen (GO:0006621)3.60790194
12regulation of autophagic vacuole assembly (GO:2000785)3.56777405
13mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48565902
14respiratory electron transport chain (GO:0022904)3.37932956
15electron transport chain (GO:0022900)3.34423465
16pyrimidine nucleobase catabolic process (GO:0006208)3.32056689
17protein complex biogenesis (GO:0070271)3.28351211
18immunoglobulin mediated immune response (GO:0016064)3.22355850
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20920012
20sequestering of metal ion (GO:0051238)3.19420001
21regulation of vacuole organization (GO:0044088)3.18046542
22hydrogen peroxide biosynthetic process (GO:0050665)3.16867516
23low-density lipoprotein particle clearance (GO:0034383)3.16198372
24amyloid precursor protein catabolic process (GO:0042987)3.13709384
25viral protein processing (GO:0019082)3.09409280
26platelet dense granule organization (GO:0060155)3.08580861
27modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.02959556
28positive regulation by organism of defense response of other organism involved in symbiotic interact3.02959556
29modulation by symbiont of host immune response (GO:0052553)3.02959556
30positive regulation by symbiont of host defense response (GO:0052509)3.02959556
31modulation by symbiont of host defense response (GO:0052031)3.02959556
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.02959556
33hydrogen ion transmembrane transport (GO:1902600)3.01701678
34epithelial cilium movement (GO:0003351)2.94957910
35positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.94325131
36aldehyde catabolic process (GO:0046185)2.91531943
37eosinophil chemotaxis (GO:0048245)2.89350687
38respiratory burst (GO:0045730)2.87944219
39positive regulation of mast cell degranulation (GO:0043306)2.86456245
40positive regulation of mast cell activation involved in immune response (GO:0033008)2.86456245
41positive regulation of mast cell activation (GO:0033005)2.82984178
42proton transport (GO:0015992)2.81393759
43COPII vesicle coating (GO:0048208)2.78165080
44hydrogen transport (GO:0006818)2.77954174
45response to peptidoglycan (GO:0032494)2.77214496
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.76442182
47NADH dehydrogenase complex assembly (GO:0010257)2.76442182
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76442182
49transferrin transport (GO:0033572)2.75202615
50microglial cell activation (GO:0001774)2.75095777
51amino sugar catabolic process (GO:0046348)2.71472811
52nucleobase catabolic process (GO:0046113)2.71386618
53reactive oxygen species biosynthetic process (GO:1903409)2.66975532
54mitochondrial respiratory chain complex assembly (GO:0033108)2.66904523
55eosinophil migration (GO:0072677)2.66644462
56trivalent inorganic cation transport (GO:0072512)2.64876800
57ferric iron transport (GO:0015682)2.64876800
58protein maturation by protein folding (GO:0022417)2.64391659
59adaptation of signaling pathway (GO:0023058)2.63537620
60retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.59504991
61chaperone-mediated protein transport (GO:0072321)2.58216474
62production of molecular mediator involved in inflammatory response (GO:0002532)2.57083458
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.54574225
64negative regulation of cell killing (GO:0031342)2.54574225
65granulocyte activation (GO:0036230)2.53312195
66behavioral response to nicotine (GO:0035095)2.51408802
67protein neddylation (GO:0045116)2.51317181
68establishment of protein localization to mitochondrial membrane (GO:0090151)2.48801692
69regulation of interferon-beta biosynthetic process (GO:0045357)2.48688995
70positive regulation of TOR signaling (GO:0032008)2.48306766
71keratan sulfate catabolic process (GO:0042340)2.48268083
72antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.44033706
73positive regulation of monocyte chemotaxis (GO:0090026)2.43465385
74positive regulation of chemokine biosynthetic process (GO:0045080)2.43037344
75protein localization to cilium (GO:0061512)2.42297740
76regulation of mast cell activation (GO:0033003)2.40123184
77cytochrome complex assembly (GO:0017004)2.40017989
78negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.39879854
79neutrophil activation (GO:0042119)2.38634310
80cilium movement (GO:0003341)2.38483670
81phagosome maturation (GO:0090382)2.36896054
82macrophage activation involved in immune response (GO:0002281)2.36869130
83regulation of mast cell degranulation (GO:0043304)2.35442030
84lipopolysaccharide-mediated signaling pathway (GO:0031663)2.35232266
85virion attachment to host cell (GO:0019062)2.35123521
86adhesion of symbiont to host cell (GO:0044650)2.35123521
87ATP biosynthetic process (GO:0006754)2.34944575
88regulation of type B pancreatic cell apoptotic process (GO:2000674)2.34201815
89regulation of cholesterol storage (GO:0010885)2.31233262
90detection of bacterium (GO:0016045)2.30515058
91adhesion of symbiont to host (GO:0044406)2.30102852
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.29924794
93L-phenylalanine catabolic process (GO:0006559)2.29924794
94regulation of mononuclear cell migration (GO:0071675)2.29340473
95regulation of cilium movement (GO:0003352)2.28544234
96activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.27956405
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.27919702
98positive regulation of interferon-alpha production (GO:0032727)2.27458306
99negative regulation of interleukin-12 production (GO:0032695)2.26751364
100detection of other organism (GO:0098543)2.26356639
101apoptotic cell clearance (GO:0043277)2.26106111
102regulation of monocyte chemotaxis (GO:0090025)2.25581607
103xenobiotic catabolic process (GO:0042178)2.25486056
104negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.24409518
105endocrine pancreas development (GO:0031018)2.24173873
106membrane protein intracellular domain proteolysis (GO:0031293)2.23956169
107virion assembly (GO:0019068)2.23871373
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.21875648
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.21875648
110ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.20955287
111regulation of mast cell activation involved in immune response (GO:0033006)2.20281322
112peptidyl-glutamic acid carboxylation (GO:0017187)2.20223226
113protein carboxylation (GO:0018214)2.20223226
114purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.19557806
115axoneme assembly (GO:0035082)2.18892602
116peptide hormone processing (GO:0016486)2.18719745
117positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.17985620
118positive regulation of antigen processing and presentation (GO:0002579)2.17908258
119plasma lipoprotein particle clearance (GO:0034381)2.17683577
120regulation of interferon-alpha production (GO:0032647)2.17610512
121cellular response to zinc ion (GO:0071294)2.17360442
122regulation of podosome assembly (GO:0071801)2.16546091
123interferon-gamma-mediated signaling pathway (GO:0060333)2.16538010
124respiratory chain complex IV assembly (GO:0008535)2.16337477
125positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.16116887
126detection of molecule of bacterial origin (GO:0032490)2.15852414
127cellular response to vitamin D (GO:0071305)2.15618116
128purine nucleoside triphosphate biosynthetic process (GO:0009145)2.15558204
129antigen processing and presentation of endogenous antigen (GO:0019883)2.15479458
130sequestering of actin monomers (GO:0042989)2.14888481
1314-hydroxyproline metabolic process (GO:0019471)2.14543434
132mitochondrion degradation (GO:0000422)2.14307219
133regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.14290025
134positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.14267458
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.14049916
136endoplasmic reticulum unfolded protein response (GO:0030968)2.13811485
137erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.13581435
138L-phenylalanine metabolic process (GO:0006558)2.13581435
139response to host immune response (GO:0052572)2.12377094
140response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.12377094
141positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.11271512
142positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.10935561
143neutrophil mediated immunity (GO:0002446)2.10782755
144positive regulation of nuclease activity (GO:0032075)2.09583459
145positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.09336919
146positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.08762192
147regulation of microtubule-based movement (GO:0060632)2.08657657
148cellular response to unfolded protein (GO:0034620)2.08449748
149potassium ion export (GO:0071435)2.08404460
150cofactor catabolic process (GO:0051187)2.08346503
151negative regulation of glycoprotein metabolic process (GO:1903019)2.08088279
152superoxide anion generation (GO:0042554)2.07990099
153hydrogen peroxide catabolic process (GO:0042744)2.07252302
154amyloid precursor protein metabolic process (GO:0042982)2.07131660
155cellular response to nicotine (GO:0071316)2.07031686
156T-helper 1 type immune response (GO:0042088)2.06827232
157macrophage activation (GO:0042116)2.06634870
158deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.06504158
159cellular response to vitamin (GO:0071295)2.06288813
160mitochondrial calcium ion transport (GO:0006851)2.06028018
161exocrine pancreas development (GO:0031017)2.05733744
162regulation of antigen processing and presentation (GO:0002577)2.05239153
163vesicle coating (GO:0006901)2.05087516
164regulation of dendritic cell antigen processing and presentation (GO:0002604)2.03859054
165negative regulation of cation channel activity (GO:2001258)2.02655651
166response to interferon-beta (GO:0035456)2.02375994
167negative regulation of myeloid cell apoptotic process (GO:0033033)2.01795983
168regulation of synapse structural plasticity (GO:0051823)2.01658781
169regulation of metalloenzyme activity (GO:0048552)2.01146687
170positive regulation of leukocyte degranulation (GO:0043302)2.01100748
171hydrogen peroxide metabolic process (GO:0042743)2.01062225
172peptide catabolic process (GO:0043171)2.00315191
173intestinal cholesterol absorption (GO:0030299)1.99583197
174intracellular pH reduction (GO:0051452)1.97997545
175cellular response to topologically incorrect protein (GO:0035967)1.97716662
176positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610811.96753046
177pH reduction (GO:0045851)1.96535289
178ER-nucleus signaling pathway (GO:0006984)1.96407958
179positive regulation of p38MAPK cascade (GO:1900745)1.96307493
180growth hormone receptor signaling pathway (GO:0060396)1.95290972
181toxin metabolic process (GO:0009404)1.94307179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.77739923
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.47672854
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.36991037
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.36339278
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.97672454
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.97045911
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.89972615
8IKZF1_21737484_ChIP-ChIP_HCT116_Human2.84582026
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.72007371
10EZH2_22144423_ChIP-Seq_EOC_Human2.66938343
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.50743884
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.41932793
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35157523
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.35136939
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.34265846
16* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32482631
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30764497
18* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29463977
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.25430876
20CLOCK_20551151_ChIP-Seq_293T_Human2.10082971
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07412115
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.99316201
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97099382
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.94071184
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.91316701
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.89112806
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.78511030
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77792995
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73754098
30* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.72838601
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68329294
32CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.68105992
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68023495
34SOX2_20726797_ChIP-Seq_SW620_Human1.61040698
35BCL6_27268052_Chip-Seq_Bcells_Human1.60900855
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60381754
37* GABP_17652178_ChIP-ChIP_JURKAT_Human1.60069189
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.57788359
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.54502978
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.54502978
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52747372
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50654964
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.50137312
44REST_21632747_ChIP-Seq_MESCs_Mouse1.49679416
45CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49075903
46EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47872200
47EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45690302
48FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45328684
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44797221
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44622113
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42267905
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.38946529
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36422675
54ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33441345
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32893623
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.32804770
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31836773
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31630269
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31148691
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31099733
61ZNF274_21170338_ChIP-Seq_K562_Hela1.30968151
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.30521418
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.27806220
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27319354
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.25514481
66NANOG_20526341_ChIP-Seq_ESCs_Human1.24965184
67CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24862950
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24838345
69STAT1_20625510_ChIP-Seq_HELA_Human1.24558080
70P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23055050
71CTCF_20526341_ChIP-Seq_ESCs_Human1.22716172
72GATA1_22025678_ChIP-Seq_K562_Human1.21108889
73* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.19352303
74RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19204740
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19133977
76TAF2_19829295_ChIP-Seq_ESCs_Human1.18950980
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17270538
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.17213650
79EGR1_19032775_ChIP-ChIP_M12_Human1.16127446
80LXR_22292898_ChIP-Seq_THP-1_Human1.15772289
81VDR_24787735_ChIP-Seq_THP-1_Human1.15536077
82CJUN_26792858_Chip-Seq_BT549_Human1.15426497
83ERA_21632823_ChIP-Seq_H3396_Human1.13274668
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13122570
85BCOR_27268052_Chip-Seq_Bcells_Human1.12566993
86* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11891365
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11633158
88* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11562076
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11139771
90ESR2_21235772_ChIP-Seq_MCF-7_Human1.09420943
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08824221
92MYC_19829295_ChIP-Seq_ESCs_Human1.08577091
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.07826239
94SA1_27219007_Chip-Seq_Bcells_Human1.06748890
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06669373
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.06510791
97* EST1_17652178_ChIP-ChIP_JURKAT_Human1.06164421
98SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06113097
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.05979022
100E2F1_20622854_ChIP-Seq_HELA_Human1.05834283
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05067767
102VDR_24763502_ChIP-Seq_THP-1_Human1.04590327
103* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04566690
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04552086
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04468027
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04122372
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04116750
108SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03461108
109SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02102734
110* TP53_22573176_ChIP-Seq_HFKS_Human1.01840710
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01293157
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00976480
113P300_27268052_Chip-Seq_Bcells_Human1.00671017
114RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99676076
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99282133
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98241296
117GATA4_25053715_ChIP-Seq_YYC3_Human0.96884374
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96383304
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.95871757
120STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95558013
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94918839
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94710973
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94268065
124HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94042115
125PHF8_20622854_ChIP-Seq_HELA_Human0.93427083
126JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93076012
127SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92989880
128LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92472305
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91970776
130ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91636076
131PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91405761
132* SPI1_23547873_ChIP-Seq_NB4_Human0.91361362
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90701058
134GATA1_19941826_ChIP-Seq_K562_Human0.90631132
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90175712
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.89908263
137SPI1_23127762_ChIP-Seq_K562_Human0.89767358
138ERG_20517297_ChIP-Seq_VCAP_Human0.89578327
139JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89417180
140PU_27001747_Chip-Seq_BMDM_Mouse0.89382369
141PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88952431
142ETS1_20019798_ChIP-Seq_JURKAT_Human0.88745989
143IGF1R_20145208_ChIP-Seq_DFB_Human0.88665041
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.88460233
145EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87989637
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87547403
147JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87413956
148CTCF_27219007_Chip-Seq_Bcells_Human0.87220590
149* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86622090
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.85831223
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85800587
152CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85478311
153SOX2_21211035_ChIP-Seq_LN229_Human0.85039807
154NCOR_22424771_ChIP-Seq_293T_Human0.85026145
155CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84719979
156CTCF_26484167_Chip-Seq_Bcells_Mouse0.84624786
157NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84520962
158AR_20517297_ChIP-Seq_VCAP_Human0.84510040
159RACK7_27058665_Chip-Seq_MCF-7_Human0.84483756
160BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.83984622
161GBX2_23144817_ChIP-Seq_PC3_Human0.83570399
162RUNX1_22412390_ChIP-Seq_EML_Mouse0.83223654
163SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82999685
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82871601
165SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.82776758
166STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82672280
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81483600
168PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79619282
169PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79366638
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78392266
171BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77657723
172* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.76362553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.64530243
2MP0008438_abnormal_cutaneous_collagen3.19113430
3MP0003436_decreased_susceptibility_to2.73142347
4MP0002653_abnormal_ependyma_morphology2.57837694
5MP0003195_calcinosis2.56618385
6MP0003011_delayed_dark_adaptation2.56254589
7MP0006082_CNS_inflammation2.32683001
8MP0005083_abnormal_biliary_tract2.32663501
9MP0003724_increased_susceptibility_to2.27853227
10MP0003880_abnormal_central_pattern2.27716042
11MP0002148_abnormal_hypersensitivity_rea2.19208082
12MP0001835_abnormal_antigen_presentation2.12686348
13MP0009840_abnormal_foam_cell2.10990566
14MP0002139_abnormal_hepatobiliary_system2.09071669
15MP0009785_altered_susceptibility_to2.05342626
16MP0001533_abnormal_skeleton_physiology2.00528511
17MP0002822_catalepsy1.97668277
18MP0010386_abnormal_urinary_bladder1.94390306
19MP0002419_abnormal_innate_immunity1.87732544
20MP0003300_gastrointestinal_ulcer1.87293489
21MP0002138_abnormal_hepatobiliary_system1.86667281
22MP0001905_abnormal_dopamine_level1.83912792
23MP0003787_abnormal_imprinting1.79818272
24MP0003183_abnormal_peptide_metabolism1.75300531
25MP0003303_peritoneal_inflammation1.75022924
26MP0005000_abnormal_immune_tolerance1.74580005
27MP0005275_abnormal_skin_tensile1.73254468
28MP0002277_abnormal_respiratory_mucosa1.71426432
29MP0003186_abnormal_redox_activity1.70252160
30MP0003191_abnormal_cellular_cholesterol1.68594628
31MP0002877_abnormal_melanocyte_morpholog1.66978874
32MP0006276_abnormal_autonomic_nervous1.64141914
33MP0003172_abnormal_lysosome_physiology1.63789901
34MP0002638_abnormal_pupillary_reflex1.63372706
35MP0005360_urolithiasis1.58054982
36MP0001790_abnormal_immune_system1.57228075
37MP0005387_immune_system_phenotype1.57228075
38MP0009643_abnormal_urine_homeostasis1.56978469
39MP0005025_abnormal_response_to1.56247366
40MP0004043_abnormal_pH_regulation1.56191213
41MP0000343_altered_response_to1.53775353
42MP0005365_abnormal_bile_salt1.53487627
43MP0004142_abnormal_muscle_tone1.52604657
44MP0002102_abnormal_ear_morphology1.51494968
45MP0000685_abnormal_immune_system1.48711568
46MP0000013_abnormal_adipose_tissue1.48546918
47MP0001958_emphysema1.48358884
48MP0002933_joint_inflammation1.46337374
49MP0003279_aneurysm1.44050940
50MP0003122_maternal_imprinting1.42385099
51MP0002837_dystrophic_cardiac_calcinosis1.40440200
52MP0002998_abnormal_bone_remodeling1.40251149
53MP0009764_decreased_sensitivity_to1.40131336
54MP0001970_abnormal_pain_threshold1.39113798
55MP0002693_abnormal_pancreas_physiology1.38684577
56MP0003705_abnormal_hypodermis_morpholog1.36561899
57MP0006054_spinal_hemorrhage1.35156929
58MP0006036_abnormal_mitochondrial_physio1.33977326
59MP0002064_seizures1.33546168
60MP0005220_abnormal_exocrine_pancreas1.33367275
61MP0003879_abnormal_hair_cell1.32267554
62MP0008469_abnormal_protein_level1.31076815
63MP0005257_abnormal_intraocular_pressure1.30218836
64MP0001666_abnormal_nutrient_absorption1.30037794
65MP0002295_abnormal_pulmonary_circulatio1.29908711
66MP0005503_abnormal_tendon_morphology1.29376143
67MP0001845_abnormal_inflammatory_respons1.29352106
68MP0009379_abnormal_foot_pigmentation1.28692476
69MP0001529_abnormal_vocalization1.28636971
70MP0004947_skin_inflammation1.26950569
71MP0009745_abnormal_behavioral_response1.22916837
72MP0001986_abnormal_taste_sensitivity1.22610609
73MP0005253_abnormal_eye_physiology1.22501554
74MP0003075_altered_response_to1.22316122
75MP0002272_abnormal_nervous_system1.22142965
76MP0005464_abnormal_platelet_physiology1.21868452
77MP0002733_abnormal_thermal_nociception1.21547260
78MP0002876_abnormal_thyroid_physiology1.20875370
79MP0009046_muscle_twitch1.19809486
80MP0006072_abnormal_retinal_apoptosis1.19571665
81MP0001756_abnormal_urination1.19410359
82MP0005390_skeleton_phenotype1.18728480
83MP0004510_myositis1.18286206
84MP0005310_abnormal_salivary_gland1.17792726
85MP0005085_abnormal_gallbladder_physiolo1.14700234
86MP0002452_abnormal_antigen_presenting1.13392943
87MP0005164_abnormal_response_to1.13213416
88MP0000604_amyloidosis1.12902166
89MP0003806_abnormal_nucleotide_metabolis1.12173346
90MP0008875_abnormal_xenobiotic_pharmacok1.11311084
91MP0005332_abnormal_amino_acid1.11305396
92MP0005636_abnormal_mineral_homeostasis1.10105538
93MP0002132_abnormal_respiratory_system1.09980037
94MP0003795_abnormal_bone_structure1.08280990
95MP0001984_abnormal_olfaction1.08242873
96MP0005075_abnormal_melanosome_morpholog1.07094437
97MP0001944_abnormal_pancreas_morphology1.06034535
98MP0003656_abnormal_erythrocyte_physiolo1.05741221
99MP0002723_abnormal_immune_serum1.05423300
100MP0003252_abnormal_bile_duct1.05422843
101MP0005645_abnormal_hypothalamus_physiol1.04993704
102MP0005167_abnormal_blood-brain_barrier1.04385987
103MP0001542_abnormal_bone_strength1.04384581
104MP0005084_abnormal_gallbladder_morpholo1.03722891
105MP0003633_abnormal_nervous_system1.03506117
106MP0002896_abnormal_bone_mineralization1.03358265
107MP0002118_abnormal_lipid_homeostasis1.03313447
108MP0005551_abnormal_eye_electrophysiolog1.02895572
109MP0005535_abnormal_body_temperature1.01945700
110MP0008789_abnormal_olfactory_epithelium1.01539261
111MP0001486_abnormal_startle_reflex1.01029235
112MP0002572_abnormal_emotion/affect_behav1.00037333
113MP0001968_abnormal_touch/_nociception0.99635801
114MP0004270_analgesia0.99599626
115MP0002405_respiratory_system_inflammati0.98285563
116MP0000538_abnormal_urinary_bladder0.98234604
117MP0002909_abnormal_adrenal_gland0.98092739
118MP0003635_abnormal_synaptic_transmissio0.98081340
119MP0003566_abnormal_cell_adhesion0.97602116
120MP0005423_abnormal_somatic_nervous0.95569305
121MP0005394_taste/olfaction_phenotype0.94062632
122MP0005499_abnormal_olfactory_system0.94062632
123MP0004885_abnormal_endolymph0.92770379
124MP0005319_abnormal_enzyme/_coenzyme0.90894454
125MP0002136_abnormal_kidney_physiology0.90636828
126MP0010329_abnormal_lipoprotein_level0.89871337
127MP0003866_abnormal_defecation0.89747256
128MP0000609_abnormal_liver_physiology0.89004373
129MP0002063_abnormal_learning/memory/cond0.88929946
130MP0004019_abnormal_vitamin_homeostasis0.88667113
131MP0002557_abnormal_social/conspecific_i0.87852409
132MP0001819_abnormal_immune_cell0.87704108
133MP0002078_abnormal_glucose_homeostasis0.87674075
134MP0001765_abnormal_ion_homeostasis0.86876791
135MP0002734_abnormal_mechanical_nocicepti0.86849575
136MP0004859_abnormal_synaptic_plasticity0.86543026
137MP0003690_abnormal_glial_cell0.86360837
138MP0002420_abnormal_adaptive_immunity0.86041812
139MP0005671_abnormal_response_to0.85965323
140MP0000858_altered_metastatic_potential0.85902201
141MP0004782_abnormal_surfactant_physiolog0.85866544
142MP0005584_abnormal_enzyme/coenzyme_acti0.85765148
143MP0002229_neurodegeneration0.85522848
144MP0001501_abnormal_sleep_pattern0.85086358
145MP0004133_heterotaxia0.84601298
146MP0003448_altered_tumor_morphology0.84348629
147MP0004742_abnormal_vestibular_system0.84229654
148MP0005166_decreased_susceptibility_to0.83859703
149MP0001800_abnormal_humoral_immune0.81965958
150MP0005379_endocrine/exocrine_gland_phen0.79758310
151MP0010155_abnormal_intestine_physiology0.77397101
152MP0000249_abnormal_blood_vessel0.75778517
153MP0004272_abnormal_basement_membrane0.75620652

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.13387261
2Dysostosis multiplex (HP:0000943)4.23173009
3Increased cerebral lipofuscin (HP:0011813)3.92695764
4Increased neuronal autofluorescent lipopigment (HP:0002074)3.84205291
5Polyphagia (HP:0002591)3.77751750
6Urinary glycosaminoglycan excretion (HP:0003541)3.73594294
7Mucopolysacchariduria (HP:0008155)3.73594294
8Eczematoid dermatitis (HP:0000976)3.72531227
9Mitochondrial inheritance (HP:0001427)3.65891886
10Acute necrotizing encephalopathy (HP:0006965)3.64540210
11Systemic lupus erythematosus (HP:0002725)3.52906679
12Recurrent gram-negative bacterial infections (HP:0005420)3.45768497
13Recurrent abscess formation (HP:0002722)3.45270317
14Abnormality of mucopolysaccharide metabolism (HP:0011020)3.37773765
15Abnormality of polysaccharide metabolism (HP:0011012)3.37773765
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.37773765
17Abnormal mitochondria in muscle tissue (HP:0008316)3.34187283
18Axonal loss (HP:0003447)3.32653206
19Recurrent bacterial skin infections (HP:0005406)3.30354196
20Abnormality of macrophages (HP:0004311)3.23061027
21Stomatitis (HP:0010280)3.18811477
22Progressive macrocephaly (HP:0004481)3.18361068
23Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.10081132
24Hepatocellular necrosis (HP:0001404)3.08144166
25Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01367456
263-Methylglutaconic aciduria (HP:0003535)3.01310452
27Renal Fanconi syndrome (HP:0001994)2.98538981
28Hypoglycemic coma (HP:0001325)2.91124685
29Increased CSF lactate (HP:0002490)2.89005015
30Hepatic necrosis (HP:0002605)2.88802595
31Mutism (HP:0002300)2.87418288
32Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87407860
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87407860
34Acute encephalopathy (HP:0006846)2.86645100
35Vertebral compression fractures (HP:0002953)2.86201721
36Agitation (HP:0000713)2.80303574
37Abnormality of liposaccharide metabolism (HP:0010968)2.73905586
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.73905586
39Abnormality of glycolipid metabolism (HP:0010969)2.73905586
40Generalized aminoaciduria (HP:0002909)2.70719612
41Lipid accumulation in hepatocytes (HP:0006561)2.70120559
42Beaking of vertebral bodies (HP:0004568)2.63780313
43Abnormal ciliary motility (HP:0012262)2.60511136
44Increased hepatocellular lipid droplets (HP:0006565)2.60257829
45Chronic obstructive pulmonary disease (HP:0006510)2.58931350
46Obstructive lung disease (HP:0006536)2.58931350
47Exertional dyspnea (HP:0002875)2.53205080
48Interstitial pulmonary disease (HP:0006530)2.51138022
49Increased intramyocellular lipid droplets (HP:0012240)2.49815304
50Abnormal respiratory motile cilium morphology (HP:0005938)2.49633340
51Abnormal respiratory epithelium morphology (HP:0012253)2.49633340
52Increased muscle lipid content (HP:0009058)2.46628273
53Xanthomatosis (HP:0000991)2.40027067
54Glomerulonephritis (HP:0000099)2.36713477
55Hypoglycemic seizures (HP:0002173)2.35463622
56Abnormal eating behavior (HP:0100738)2.34640389
57Ketoacidosis (HP:0001993)2.34507369
58Myokymia (HP:0002411)2.32402455
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.32292242
60Absent/shortened dynein arms (HP:0200106)2.32292242
61Abnormal respiratory motile cilium physiology (HP:0012261)2.29030239
62Cervical subluxation (HP:0003308)2.26982290
63Petechiae (HP:0000967)2.26018814
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.25690589
65Symptomatic seizures (HP:0011145)2.25657151
66Protuberant abdomen (HP:0001538)2.25257277
67Peritonitis (HP:0002586)2.24338926
68Abnormality of renal resorption (HP:0011038)2.24098624
69Premature rupture of membranes (HP:0001788)2.22394103
70Respiratory failure (HP:0002878)2.19049114
71Abnormal rod and cone electroretinograms (HP:0008323)2.17545766
72Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.17330736
73Methylmalonic aciduria (HP:0012120)2.16197328
74Ovoid vertebral bodies (HP:0003300)2.14100109
75Hypochromic microcytic anemia (HP:0004840)2.13020325
76Medial flaring of the eyebrow (HP:0010747)2.12585440
77Complement deficiency (HP:0004431)2.08642947
78Hydroxyprolinuria (HP:0003080)2.06157681
79Abnormality of proline metabolism (HP:0010907)2.06157681
80Progressive neurologic deterioration (HP:0002344)2.03897288
81Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03330736
82Abnormality of the intrinsic pathway (HP:0010989)2.02930514
83Hypothermia (HP:0002045)2.01990417
84Gingivitis (HP:0000230)2.01339774
85Molar tooth sign on MRI (HP:0002419)2.00998531
86Abnormality of midbrain morphology (HP:0002418)2.00998531
87Protrusio acetabuli (HP:0003179)1.99252616
88Lactic acidosis (HP:0003128)1.99042319
89Hyperparathyroidism (HP:0000843)1.98808519
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98693151
91Hyperinsulinemic hypoglycemia (HP:0000825)1.97713312
92Elevated erythrocyte sedimentation rate (HP:0003565)1.97448982
93Tetraparesis (HP:0002273)1.97261170
94Myocardial infarction (HP:0001658)1.96864610
95Abnormality of the common coagulation pathway (HP:0010990)1.96186723
96Prolonged neonatal jaundice (HP:0006579)1.95600459
97Mediastinal lymphadenopathy (HP:0100721)1.95486948
98Late onset (HP:0003584)1.95003391
99Optic disc pallor (HP:0000543)1.94754192
100Loss of speech (HP:0002371)1.93810158
101Abnormality of purine metabolism (HP:0004352)1.93609610
102Autoimmune thrombocytopenia (HP:0001973)1.93493565
103Abnormality of complement system (HP:0005339)1.93137664
104Ketosis (HP:0001946)1.93071255
105Abnormal tarsal ossification (HP:0008369)1.92180472
106Cerebral edema (HP:0002181)1.92143481
107Optic neuritis (HP:0100653)1.91904900
108Retrobulbar optic neuritis (HP:0100654)1.91904900
109Asymmetric septal hypertrophy (HP:0001670)1.91565905
110Limb dystonia (HP:0002451)1.91460384
111True hermaphroditism (HP:0010459)1.91166207
112Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90748323
113Chronic sinusitis (HP:0011109)1.89949418
114Gait imbalance (HP:0002141)1.89556754
115Dicarboxylic aciduria (HP:0003215)1.88724928
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88724928
117Pathologic fracture (HP:0002756)1.87752101
118Episodic fever (HP:0001954)1.87253669
119Abnormality of glutamine family amino acid metabolism (HP:0010902)1.86530529
120Joint stiffness (HP:0001387)1.86325510
121Retinal atrophy (HP:0001105)1.85727198
122Pancreatic cysts (HP:0001737)1.85619570
123Abnormality of fatty-acid metabolism (HP:0004359)1.85166881
124Disinhibition (HP:0000734)1.84594588
125Recurrent skin infections (HP:0001581)1.83462575
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82572634
127Urticaria (HP:0001025)1.81989214
128Orchitis (HP:0100796)1.81767545
129Pancreatic fibrosis (HP:0100732)1.80743228
130Bone cyst (HP:0012062)1.80000430
131Purpura (HP:0000979)1.79624634
132Nephritis (HP:0000123)1.79069288
133Skin nodule (HP:0200036)1.78940935
134Joint hemorrhage (HP:0005261)1.78523050
135Emotional lability (HP:0000712)1.78413728
136Congenital primary aphakia (HP:0007707)1.75369341
137Neurofibrillary tangles (HP:0002185)1.74952445
138Abdominal distention (HP:0003270)1.74340273
139Hemiparesis (HP:0001269)1.73602622
140Hepatosplenomegaly (HP:0001433)1.73335128
141Myositis (HP:0100614)1.73184722
142Nephrogenic diabetes insipidus (HP:0009806)1.72599889
143Amyloidosis (HP:0011034)1.72408422
144Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.70711076
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.70363709
146Exocrine pancreatic insufficiency (HP:0001738)1.69837542
147Hyperactive renin-angiotensin system (HP:0000841)1.68637428
148Thoracolumbar scoliosis (HP:0002944)1.68028589
149Hypophosphatemia (HP:0002148)1.67946931
150Gout (HP:0001997)1.67697640
151Exercise intolerance (HP:0003546)1.67558308
152Cupped ribs (HP:0000887)1.67475344
153Elevated alkaline phosphatase (HP:0003155)1.66996755
154Poor head control (HP:0002421)1.65671028
155Abolished electroretinogram (ERG) (HP:0000550)1.64888406
156Mitral stenosis (HP:0001718)1.64693126
157Glycosuria (HP:0003076)1.64472847
158Abnormality of urine glucose concentration (HP:0011016)1.64472847
159Supranuclear gaze palsy (HP:0000605)1.64053439
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63148538
161Abnormal enzyme/coenzyme activity (HP:0012379)1.61537608
162Pancreatitis (HP:0001733)1.61232509
163Cerebral hemorrhage (HP:0001342)1.60917090
164Hypokalemic alkalosis (HP:0001949)1.60203326
165Thin bony cortex (HP:0002753)1.59364760
166Abnormality of chloride homeostasis (HP:0011422)1.59237451
167Progressive visual loss (HP:0000529)1.58571298
168Abnormality of alkaline phosphatase activity (HP:0004379)1.57403444
169Abnormal cartilage morphology (HP:0002763)1.56838294
170Segmental peripheral demyelination/remyelination (HP:0003481)1.55325091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.47839345
2TRIB32.70970151
3TBK12.45379006
4PINK12.34640734
5EPHB12.28082093
6PIM22.25402706
7STK162.16570485
8TESK12.14083127
9BLK2.10881841
10CDK192.10653147
11DYRK22.09682033
12IRAK31.98140034
13EPHA31.95394153
14BCKDK1.92982613
15MAPK151.83674341
16ADRBK21.78905840
17MAP4K21.78161076
18INSRR1.76522881
19MAP3K141.73565621
20WNK41.70950762
21ARAF1.70342014
22TNK21.69636534
23VRK21.63846335
24PBK1.63027525
25IRAK41.61164159
26TAOK31.60869178
27NME21.60699170
28MARK11.55013456
29DAPK21.54432260
30MAP2K71.53574337
31MAP3K121.52685246
32CSNK1G31.44474783
33PIK3CG1.41298862
34WNK31.40873641
35TYK21.40398884
36LIMK11.39974648
37TAOK11.39921352
38CSNK1G21.39696807
39MST41.39227214
40MAP3K31.33568341
41MST1R1.32816374
42JAK31.31439092
43DYRK31.31315645
44IRAK11.30453059
45FES1.29202706
46MET1.28526541
47MAP3K21.27954902
48LRRK21.26859907
49GRK11.24758014
50RIPK41.24650345
51GRK61.24099970
52TGFBR21.22633317
53FGFR41.21985820
54ZAP701.18650245
55IKBKB1.17512848
56PTK61.15390826
57CSK1.12150723
58MAPK131.11739110
59FRK1.11099428
60IKBKE1.10777972
61MYLK1.08726922
62EPHB21.08333386
63ABL21.08330840
64MAP2K21.07369573
65CSNK1A1L1.06645874
66SIK11.06559886
67GRK51.04123468
68PTK21.03554583
69DDR21.00856659
70CSNK1G11.00496513
71JAK10.98157465
72DYRK1B0.98110555
73MAP3K40.97713689
74NEK90.96834743
75FLT30.96774527
76TXK0.96397846
77CASK0.94808834
78MAP3K10.93227577
79MAP2K40.93218255
80HIPK20.93153322
81MAP3K110.91677403
82NTRK10.91349413
83PHKG20.91263706
84PHKG10.91263706
85PRKG20.90594684
86TESK20.88790324
87NTRK30.84266798
88KIT0.84101332
89PDGFRA0.77207549
90ADRBK10.76729858
91BMX0.76318858
92STK390.75835941
93MINK10.75645079
94MAP2K30.74622354
95JAK20.74426674
96MARK30.73929151
97BTK0.72184242
98IRAK20.71164292
99PRKCG0.70860796
100CSF1R0.70611770
101BMPR1B0.70215577
102RIPK10.69830653
103HCK0.68574827
104ILK0.68493350
105PKN20.68375061
106KDR0.67819812
107UHMK10.67777074
108TTN0.67633445
109MAP4K10.65171924
110FGR0.65165452
111CHUK0.64467830
112TRPM70.62771717
113MAP2K10.62338348
114CAMKK20.61803099
115MOS0.60354063
116PRKCQ0.58638875
117MAP3K50.58096366
118PAK30.57578511
119SYK0.57310328
120NTRK20.56384379
121PASK0.56167126
122DAPK30.55497807
123BMPR20.55493703
124MAP2K60.54969004
125PRKCD0.54923345
126PRKCE0.54243186
127PKN10.54133496
128KSR20.53766370
129CDK50.52775629
130SGK4940.52524059
131SGK2230.52524059
132LYN0.52509664
133OXSR10.51898737
134MARK20.50984393
135LCK0.49844684
136STK110.49448598
137BCR0.48730809
138PRKD20.47610462
139SIK20.46562539
140MATK0.46373147
141GRK70.45957417
142ITK0.45576499
143MAPKAPK30.45523405
144FER0.45384578
145GSK3A0.45249194
146TEC0.45100960
147PRKD10.43946303
148RPS6KA40.43773515
149PRKCH0.42194489
150SCYL20.41841004
151EGFR0.41461570
152PTK2B0.41416054
153PDPK10.40892286
154MAPKAPK20.39994385
155PAK40.39897136

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.20127774
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.88076435
3Lysosome_Homo sapiens_hsa041422.62619488
4Sulfur metabolism_Homo sapiens_hsa009202.49417517
5Huntingtons disease_Homo sapiens_hsa050162.11763218
6Staphylococcus aureus infection_Homo sapiens_hsa051502.10072830
7Other glycan degradation_Homo sapiens_hsa005112.09282317
8Autoimmune thyroid disease_Homo sapiens_hsa053202.04300864
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.02107666
10Synaptic vesicle cycle_Homo sapiens_hsa047211.99474151
11Cardiac muscle contraction_Homo sapiens_hsa042601.87112560
12Vibrio cholerae infection_Homo sapiens_hsa051101.83173216
13Rheumatoid arthritis_Homo sapiens_hsa053231.73012583
14Phagosome_Homo sapiens_hsa041451.68915770
15Leishmaniasis_Homo sapiens_hsa051401.66447468
16Steroid biosynthesis_Homo sapiens_hsa001001.64636281
17Ribosome_Homo sapiens_hsa030101.59724257
18Legionellosis_Homo sapiens_hsa051341.53916596
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49635875
20Collecting duct acid secretion_Homo sapiens_hsa049661.45607010
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43162559
22Malaria_Homo sapiens_hsa051441.41568478
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41406951
24Pertussis_Homo sapiens_hsa051331.40574614
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34031332
26Oxidative phosphorylation_Homo sapiens_hsa001901.29908483
27Histidine metabolism_Homo sapiens_hsa003401.29293479
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26291620
29Folate biosynthesis_Homo sapiens_hsa007901.23046738
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21206735
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20965850
32Tuberculosis_Homo sapiens_hsa051521.19650079
33Fatty acid elongation_Homo sapiens_hsa000621.19391876
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19040964
35Tryptophan metabolism_Homo sapiens_hsa003801.17647123
36Complement and coagulation cascades_Homo sapiens_hsa046101.16250062
37Fatty acid degradation_Homo sapiens_hsa000711.15434931
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12146187
39Proteasome_Homo sapiens_hsa030501.10705523
40Osteoclast differentiation_Homo sapiens_hsa043801.03945040
41Graft-versus-host disease_Homo sapiens_hsa053321.03251126
42Peroxisome_Homo sapiens_hsa041461.00281938
43Caffeine metabolism_Homo sapiens_hsa002320.99673116
44Asthma_Homo sapiens_hsa053100.99557945
45Fat digestion and absorption_Homo sapiens_hsa049750.97639975
46Phototransduction_Homo sapiens_hsa047440.96741114
47Salmonella infection_Homo sapiens_hsa051320.94061316
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94038901
49Viral myocarditis_Homo sapiens_hsa054160.92459606
50Fatty acid metabolism_Homo sapiens_hsa012120.91233347
51Starch and sucrose metabolism_Homo sapiens_hsa005000.90678304
52Prion diseases_Homo sapiens_hsa050200.89238893
53* Regulation of autophagy_Homo sapiens_hsa041400.88104126
54Phenylalanine metabolism_Homo sapiens_hsa003600.86698317
55PPAR signaling pathway_Homo sapiens_hsa033200.83810842
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83766723
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83546611
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83534636
59Shigellosis_Homo sapiens_hsa051310.82591496
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.82409271
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82078792
62TNF signaling pathway_Homo sapiens_hsa046680.80240311
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79875084
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79098001
65Butanoate metabolism_Homo sapiens_hsa006500.77053792
66Parkinsons disease_Homo sapiens_hsa050120.76722103
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76060781
68Toxoplasmosis_Homo sapiens_hsa051450.75456483
69Primary immunodeficiency_Homo sapiens_hsa053400.75176715
70Chemical carcinogenesis_Homo sapiens_hsa052040.74418625
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74190277
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73470990
73Type I diabetes mellitus_Homo sapiens_hsa049400.72375439
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.72200818
75Sphingolipid metabolism_Homo sapiens_hsa006000.71756220
76Hematopoietic cell lineage_Homo sapiens_hsa046400.71490035
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71190031
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70201539
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70121861
80Alzheimers disease_Homo sapiens_hsa050100.70057756
81Ether lipid metabolism_Homo sapiens_hsa005650.69815355
82Morphine addiction_Homo sapiens_hsa050320.69412907
83Protein digestion and absorption_Homo sapiens_hsa049740.69276456
84Mineral absorption_Homo sapiens_hsa049780.69032822
85Insulin secretion_Homo sapiens_hsa049110.68932223
86* GABAergic synapse_Homo sapiens_hsa047270.68643302
87Allograft rejection_Homo sapiens_hsa053300.68424360
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.68051474
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67637629
90Amoebiasis_Homo sapiens_hsa051460.67562001
91Galactose metabolism_Homo sapiens_hsa000520.67078681
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66306701
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66053179
94Propanoate metabolism_Homo sapiens_hsa006400.65787967
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65746166
96Glutathione metabolism_Homo sapiens_hsa004800.65315420
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65031362
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64822823
99Cocaine addiction_Homo sapiens_hsa050300.63432555
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63299988
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62868700
102Nicotine addiction_Homo sapiens_hsa050330.62021770
103Dopaminergic synapse_Homo sapiens_hsa047280.61972215
104Circadian entrainment_Homo sapiens_hsa047130.61418549
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60943832
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60289028
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58913921
108N-Glycan biosynthesis_Homo sapiens_hsa005100.58558669
109Tyrosine metabolism_Homo sapiens_hsa003500.57600420
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.54098468
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.53432041
112Linoleic acid metabolism_Homo sapiens_hsa005910.52679670
113Insulin resistance_Homo sapiens_hsa049310.52022684
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51851026
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51813637
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51526402
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51291278
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.50870165
119Apoptosis_Homo sapiens_hsa042100.49506707
120beta-Alanine metabolism_Homo sapiens_hsa004100.49421209
121Chemokine signaling pathway_Homo sapiens_hsa040620.46901336
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45894935
123Antigen processing and presentation_Homo sapiens_hsa046120.45775497
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45624975
125Serotonergic synapse_Homo sapiens_hsa047260.45363355
126Renin-angiotensin system_Homo sapiens_hsa046140.45252431
127Arachidonic acid metabolism_Homo sapiens_hsa005900.45234344
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44704287
129Pancreatic secretion_Homo sapiens_hsa049720.44703030
130Arginine and proline metabolism_Homo sapiens_hsa003300.43714152
131Metabolic pathways_Homo sapiens_hsa011000.42959619
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37467789
133African trypanosomiasis_Homo sapiens_hsa051430.36257361
134Endocytosis_Homo sapiens_hsa041440.35857668
135Salivary secretion_Homo sapiens_hsa049700.35010146
136Olfactory transduction_Homo sapiens_hsa047400.33119501
137Glutamatergic synapse_Homo sapiens_hsa047240.31795400
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29184546
139Nitrogen metabolism_Homo sapiens_hsa009100.27997311
140Renin secretion_Homo sapiens_hsa049240.26194057

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