G6PC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Glucose-6-phosphatase (G6Pase) is a multi-subunit integral membrane protein of the endoplasmic reticulum that is composed of a catalytic subunit and transporters for G6P, inorganic phosphate, and glucose. This gene (G6PC) is one of the three glucose-6-phosphatase catalytic-subunit-encoding genes in human: G6PC, G6PC2 and G6PC3. Glucose-6-phosphatase catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate and is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Mutations in this gene cause glycogen storage disease type I (GSD1). This disease, also known as von Gierke disease, is a metabolic disorder characterized by severe hypoglycemia associated with the accumulation of glycogen and fat in the liver and kidneys. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.74201138
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.67947930
3L-phenylalanine catabolic process (GO:0006559)7.67947930
4L-phenylalanine metabolic process (GO:0006558)7.36539649
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.36539649
6aromatic amino acid family catabolic process (GO:0009074)7.00497238
7omega-hydroxylase P450 pathway (GO:0097267)6.61747489
8indole-containing compound catabolic process (GO:0042436)6.40741147
9indolalkylamine catabolic process (GO:0046218)6.40741147
10tryptophan catabolic process (GO:0006569)6.40741147
11glyoxylate metabolic process (GO:0046487)6.27272044
12kynurenine metabolic process (GO:0070189)6.10936202
13tryptophan metabolic process (GO:0006568)6.02872357
14bile acid biosynthetic process (GO:0006699)5.88848376
15cysteine metabolic process (GO:0006534)5.79570723
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.66839420
17blood coagulation, intrinsic pathway (GO:0007597)5.44712000
18urea metabolic process (GO:0019627)5.42913913
19urea cycle (GO:0000050)5.42913913
20lysine catabolic process (GO:0006554)5.39580507
21lysine metabolic process (GO:0006553)5.39580507
22alpha-linolenic acid metabolic process (GO:0036109)5.39393575
23very-low-density lipoprotein particle assembly (GO:0034379)5.39107329
24serine family amino acid catabolic process (GO:0009071)5.36887643
25sulfur amino acid catabolic process (GO:0000098)5.36646374
26homocysteine metabolic process (GO:0050667)5.23004061
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.21538646
28aromatic amino acid family metabolic process (GO:0009072)5.09366152
29negative regulation of fibrinolysis (GO:0051918)5.09212824
30intestinal cholesterol absorption (GO:0030299)5.02420394
31complement activation, alternative pathway (GO:0006957)5.01711568
32nitrogen cycle metabolic process (GO:0071941)5.01524123
33positive regulation of lipoprotein lipase activity (GO:0051006)4.97445962
34positive regulation of triglyceride lipase activity (GO:0061365)4.97445962
35regulation of plasminogen activation (GO:0010755)4.97442150
36peptidyl-glutamic acid carboxylation (GO:0017187)4.96844721
37protein carboxylation (GO:0018214)4.96844721
38high-density lipoprotein particle remodeling (GO:0034375)4.95492150
39bile acid metabolic process (GO:0008206)4.95350249
40regulation of protein activation cascade (GO:2000257)4.94808632
41regulation of fibrinolysis (GO:0051917)4.90344835
42protein activation cascade (GO:0072376)4.85698864
43amino-acid betaine metabolic process (GO:0006577)4.82772760
44alpha-amino acid catabolic process (GO:1901606)4.78904161
45tyrosine metabolic process (GO:0006570)4.76622575
46regulation of complement activation (GO:0030449)4.63758848
47cellular ketone body metabolic process (GO:0046950)4.58873857
48complement activation, classical pathway (GO:0006958)4.55932807
49negative regulation of protein activation cascade (GO:2000258)4.53939834
50indolalkylamine metabolic process (GO:0006586)4.53887497
51drug transmembrane transport (GO:0006855)4.52165653
52acute-phase response (GO:0006953)4.52052185
53plasma lipoprotein particle organization (GO:0071827)4.51012623
54oxidative demethylation (GO:0070989)4.50556055
55drug catabolic process (GO:0042737)4.49418873
56regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.48351122
57serine family amino acid metabolic process (GO:0009069)4.48280929
58protein-lipid complex assembly (GO:0065005)4.47881170
59regulation of triglyceride catabolic process (GO:0010896)4.47184378
60glutamate metabolic process (GO:0006536)4.46072946
61regulation of humoral immune response (GO:0002920)4.45569933
62cellular amino acid catabolic process (GO:0009063)4.45418514
63complement activation (GO:0006956)4.45170772
64negative regulation of blood coagulation (GO:0030195)4.43033147
65negative regulation of hemostasis (GO:1900047)4.43033147
66glycine metabolic process (GO:0006544)4.41079417
67cellular biogenic amine catabolic process (GO:0042402)4.40660029
68amine catabolic process (GO:0009310)4.40660029
69cellular modified amino acid catabolic process (GO:0042219)4.39124950
70coenzyme catabolic process (GO:0009109)4.36950389
71triglyceride homeostasis (GO:0070328)4.33029819
72acylglycerol homeostasis (GO:0055090)4.33029819
73negative regulation of cholesterol transport (GO:0032375)4.31996010
74negative regulation of sterol transport (GO:0032372)4.31996010
75reverse cholesterol transport (GO:0043691)4.31978073
76regulation of cholesterol esterification (GO:0010872)4.29504473
77regulation of apoptotic cell clearance (GO:2000425)4.29100417
78protein-lipid complex remodeling (GO:0034368)4.27747876
79macromolecular complex remodeling (GO:0034367)4.27747876
80plasma lipoprotein particle remodeling (GO:0034369)4.27747876
81intestinal absorption (GO:0050892)4.26303622
82fat-soluble vitamin biosynthetic process (GO:0042362)4.23719754
83benzene-containing compound metabolic process (GO:0042537)4.22692856
84protein-lipid complex subunit organization (GO:0071825)4.21204926
85serine family amino acid biosynthetic process (GO:0009070)4.20138811
86positive regulation of fatty acid biosynthetic process (GO:0045723)4.17445312
87cellular glucuronidation (GO:0052695)4.17445279
88bile acid and bile salt transport (GO:0015721)4.16770413
89flavonoid metabolic process (GO:0009812)4.15424846
90ethanol metabolic process (GO:0006067)4.11993786
91ethanol oxidation (GO:0006069)4.11633867
92dicarboxylic acid biosynthetic process (GO:0043650)4.10711298
93short-chain fatty acid metabolic process (GO:0046459)4.09668515
94* urate metabolic process (GO:0046415)4.09210490
95imidazole-containing compound metabolic process (GO:0052803)4.08783776
96aldehyde catabolic process (GO:0046185)4.06627254
97negative regulation of coagulation (GO:0050819)4.05793150
98hormone catabolic process (GO:0042447)4.05268447
99exogenous drug catabolic process (GO:0042738)4.05175035
100phospholipid efflux (GO:0033700)4.01019103
101acetyl-CoA metabolic process (GO:0006084)4.00258352
102negative regulation of wound healing (GO:0061045)3.98717185
103ketone body metabolic process (GO:1902224)3.97050728
104positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.95559157
105plasma lipoprotein particle clearance (GO:0034381)3.93661452
106aspartate family amino acid catabolic process (GO:0009068)3.93087664
107phenylpropanoid metabolic process (GO:0009698)3.92339574
108organic acid catabolic process (GO:0016054)3.91362215
109carboxylic acid catabolic process (GO:0046395)3.91362215
110arginine metabolic process (GO:0006525)3.88515967
111lipoprotein metabolic process (GO:0042157)3.88094339
112negative regulation of lipase activity (GO:0060192)3.84818152
113cytolysis (GO:0019835)3.83758295
114alkaloid metabolic process (GO:0009820)3.81383983
115positive regulation of hemostasis (GO:1900048)3.81178325
116positive regulation of blood coagulation (GO:0030194)3.81178325
117uronic acid metabolic process (GO:0006063)3.79142340
118glucuronate metabolic process (GO:0019585)3.79142340
1192-oxoglutarate metabolic process (GO:0006103)3.79097567
120proline metabolic process (GO:0006560)3.76806440
121drug transport (GO:0015893)3.75907394
122positive regulation of lipid catabolic process (GO:0050996)3.74891266
123cholesterol efflux (GO:0033344)3.73630111
124regulation of cholesterol homeostasis (GO:2000188)3.72843377
125fibrinolysis (GO:0042730)3.71167249
126regulation of bile acid biosynthetic process (GO:0070857)3.70455045
127negative regulation of complement activation (GO:0045916)3.64438401
128fatty acid beta-oxidation (GO:0006635)3.64316534
129fatty acid oxidation (GO:0019395)3.63934379
130cofactor catabolic process (GO:0051187)3.63430313
131monocarboxylic acid catabolic process (GO:0072329)3.62431534
132phospholipid homeostasis (GO:0055091)3.58987158
133low-density lipoprotein particle remodeling (GO:0034374)3.58753905
134lipid oxidation (GO:0034440)3.56942171
135carnitine metabolic process (GO:0009437)3.56941763
136plasma lipoprotein particle assembly (GO:0034377)3.56340962
137opsonization (GO:0008228)3.54015266
138* cholesterol homeostasis (GO:0042632)3.52506538
139drug metabolic process (GO:0017144)3.51916985
140response to mercury ion (GO:0046689)3.50896646
141positive regulation of coagulation (GO:0050820)3.50574704
142nicotinamide nucleotide biosynthetic process (GO:0019359)3.50421713
143pyridine nucleotide biosynthetic process (GO:0019363)3.50421713
144NAD biosynthetic process (GO:0009435)3.50288601
145* sterol homeostasis (GO:0055092)3.46526245
146angiotensin maturation (GO:0002003)3.44164403
147S-adenosylmethionine metabolic process (GO:0046500)3.41435341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.34234091
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13726943
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.73018799
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.44616861
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17808163
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.83366548
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.79262025
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.99047100
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.85162950
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.14116774
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13262681
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10441833
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6974643
14CLOCK_20551151_ChIP-Seq_293T_Human1.66422816
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65267007
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62425851
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46866458
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.37434711
19HTT_18923047_ChIP-ChIP_STHdh_Human1.36085858
20GATA1_22025678_ChIP-Seq_K562_Human1.31387541
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24684408
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17596334
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.16822290
24RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14710749
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12854668
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06047826
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05570904
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05437201
29* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04986783
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04793627
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02369743
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02064714
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00839119
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97844248
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.97672721
36GATA4_25053715_ChIP-Seq_YYC3_Human0.89990575
37NFE2_27457419_Chip-Seq_LIVER_Mouse0.88511373
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88002806
39ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87055635
40ESR2_21235772_ChIP-Seq_MCF-7_Human0.86088436
41PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85661492
42ESR1_21235772_ChIP-Seq_MCF-7_Human0.82728120
43BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81037584
44IRF8_22096565_ChIP-ChIP_GC-B_Human0.80724964
45AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80029114
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78196140
47SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77364956
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74852722
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73947393
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73204209
51RAC3_21632823_ChIP-Seq_H3396_Human0.72709257
52ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72650134
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72522385
54SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71524998
55ZNF263_19887448_ChIP-Seq_K562_Human0.71491062
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70941536
57SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70268539
58MYC_19829295_ChIP-Seq_ESCs_Human0.70260245
59SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69242752
60* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67863133
61NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67506819
62NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67506819
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.66724624
64CDX2_20551321_ChIP-Seq_CACO-2_Human0.65903191
65* RARA_24833708_ChIP-Seq_LIVER_Mouse0.65633487
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.65344585
67DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65285865
68EGR1_19032775_ChIP-ChIP_M12_Human0.64883983
69EZH2_27294783_Chip-Seq_NPCs_Mouse0.64480080
70SOX2_21211035_ChIP-Seq_LN229_Human0.64355653
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.62977192
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.62184620
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61377638
74SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60959617
75* LXR_22292898_ChIP-Seq_THP-1_Human0.60325058
76ESRRB_18555785_Chip-Seq_ESCs_Mouse0.60162170
77STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59835938
78CEBPB_22108803_ChIP-Seq_LS180_Human0.59737331
79RUNX1_27457419_Chip-Seq_LIVER_Mouse0.58737074
80HNFA_21074721_ChIP-Seq_CACO-2_Human0.57042795
81POU5F1_16518401_ChIP-PET_MESCs_Mouse0.56745580
82FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56591509
83CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56507522
84FOXH1_21741376_ChIP-Seq_ESCs_Human0.56401920
85AR_20517297_ChIP-Seq_VCAP_Human0.55885954
86CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.55790335
87CTCF_27219007_Chip-Seq_Bcells_Human0.55695887
88MYC_19915707_ChIP-ChIP_AK7_Human0.55575654
89* RARB_24833708_ChIP-Seq_LIVER_Mouse0.55370101
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.55157683
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.53902819
92FOXA1_25552417_ChIP-Seq_VCAP_Human0.53548319
93TP53_16413492_ChIP-PET_HCT116_Human0.53234152
94TCF4_22108803_ChIP-Seq_LS180_Human0.53167575
95NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.52653514
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.52229366
97ETV1_20927104_ChIP-Seq_GIST48_Human0.52170024
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.52120531
99PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51382169
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51205051
101ESET_19884257_ChIP-Seq_ESCs_Mouse0.50956859
102CBP_21632823_ChIP-Seq_H3396_Human0.50344599
103STAT1_17558387_ChIP-Seq_HELA_Human0.49665207
104GATA6_25053715_ChIP-Seq_YYC3_Human0.48705436
105PPAR_26484153_Chip-Seq_NCI-H1993_Human0.47403675
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.46920815
107TAF2_19829295_ChIP-Seq_ESCs_Human0.46800073
108* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45382637
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.45221324
110GATA2_19941826_ChIP-Seq_K562_Human0.43485302
111P53_21459846_ChIP-Seq_SAOS-2_Human0.43418757
112GATA1_19941826_ChIP-Seq_K562_Human0.42353973
113ERG_21242973_ChIP-ChIP_JURKAT_Human0.42345714
114TAF15_26573619_Chip-Seq_HEK293_Human0.41812053
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41667258
116* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41484060
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.41452698
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.40349516
119* GATA1_19941827_ChIP-Seq_MEL_Mouse0.40305447
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.40285766
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40007586
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39984296
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39957129
124CDX2_22108803_ChIP-Seq_LS180_Human0.39946120
125BCAT_22108803_ChIP-Seq_LS180_Human0.39050278
126ESR1_20079471_ChIP-ChIP_T-47D_Human0.38537657
127FOXH1_21741376_ChIP-Seq_EPCs_Human0.37976985
128SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.37718575
129SOX2_20726797_ChIP-Seq_SW620_Human0.37361155
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37271885
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.37187395
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36687402
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.36637648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.16297988
2MP0005360_urolithiasis7.97861102
3MP0005085_abnormal_gallbladder_physiolo6.19709601
4MP0005365_abnormal_bile_salt5.91603453
5MP0008875_abnormal_xenobiotic_pharmacok4.99164495
6MP0003806_abnormal_nucleotide_metabolis4.02735507
7MP0003252_abnormal_bile_duct3.99646107
8MP0010329_abnormal_lipoprotein_level3.33849430
9MP0005332_abnormal_amino_acid3.23520381
10MP0003195_calcinosis3.21747376
11MP0009840_abnormal_foam_cell2.84393180
12MP0005083_abnormal_biliary_tract2.83647775
13MP0004019_abnormal_vitamin_homeostasis2.66894276
14MP0001666_abnormal_nutrient_absorption2.52370635
15MP0002138_abnormal_hepatobiliary_system2.36500584
16MP0003191_abnormal_cellular_cholesterol2.14196333
17* MP0000609_abnormal_liver_physiology2.02572772
18* MP0002118_abnormal_lipid_homeostasis2.00661394
19MP0005319_abnormal_enzyme/_coenzyme1.86259249
20MP0003868_abnormal_feces_composition1.75391690
21MP0009643_abnormal_urine_homeostasis1.68790485
22MP0001764_abnormal_homeostasis1.66902601
23MP0005584_abnormal_enzyme/coenzyme_acti1.65060068
24MP0005451_abnormal_body_composition1.52543619
25MP0003186_abnormal_redox_activity1.39119873
26MP0003183_abnormal_peptide_metabolism1.39109561
27MP0000566_synostosis1.38295533
28MP0005636_abnormal_mineral_homeostasis1.30640539
29MP0009697_abnormal_copulation1.28102621
30MP0003011_delayed_dark_adaptation1.18045722
31MP0004043_abnormal_pH_regulation1.13541528
32* MP0000598_abnormal_liver_morphology1.11521700
33MP0003122_maternal_imprinting1.11519480
34MP0002132_abnormal_respiratory_system1.07570689
35MP0003656_abnormal_erythrocyte_physiolo1.06342562
36MP0003705_abnormal_hypodermis_morpholog1.05920090
37MP0009764_decreased_sensitivity_to1.05614850
38MP0005647_abnormal_sex_gland1.04401841
39MP0001756_abnormal_urination1.01556905
40MP0003879_abnormal_hair_cell1.00555803
41MP0005670_abnormal_white_adipose0.96495800
42MP0000604_amyloidosis0.95590865
43MP0005084_abnormal_gallbladder_morpholo0.92682973
44MP0006036_abnormal_mitochondrial_physio0.91816841
45MP0009763_increased_sensitivity_to0.91454821
46* MP0009642_abnormal_blood_homeostasis0.88507027
47MP0008469_abnormal_protein_level0.87813692
48MP0005409_darkened_coat_color0.87635600
49MP0002876_abnormal_thyroid_physiology0.86989548
50MP0002136_abnormal_kidney_physiology0.85118390
51MP0002254_reproductive_system_inflammat0.84721710
52MP0005408_hypopigmentation0.82355111
53MP0002089_abnormal_postnatal_growth/wei0.77860496
54MP0005220_abnormal_exocrine_pancreas0.77396289
55MP0010368_abnormal_lymphatic_system0.76864129
56MP0005535_abnormal_body_temperature0.76719729
57MP0005376_homeostasis/metabolism_phenot0.75753696
58* MP0002078_abnormal_glucose_homeostasis0.74404450
59MP0009765_abnormal_xenobiotic_induced0.73175804
60MP0001765_abnormal_ion_homeostasis0.72165146
61MP0001915_intracranial_hemorrhage0.71472916
62MP0001661_extended_life_span0.70781968
63MP0002971_abnormal_brown_adipose0.70559169
64MP0002928_abnormal_bile_duct0.64579376
65MP0005334_abnormal_fat_pad0.63785111
66MP0004130_abnormal_muscle_cell0.60773337
67MP0005266_abnormal_metabolism0.60407504
68MP0003329_amyloid_beta_deposits0.59701652
69MP0006035_abnormal_mitochondrial_morpho0.59642913
70MP0003690_abnormal_glial_cell0.57636250
71MP0009053_abnormal_anal_canal0.55855368
72MP0003638_abnormal_response/metabolism_0.52768004
73MP0005395_other_phenotype0.52717531
74MP0010155_abnormal_intestine_physiology0.52673071
75MP0005666_abnormal_adipose_tissue0.50144880
76MP0003172_abnormal_lysosome_physiology0.49057085
77MP0000230_abnormal_systemic_arterial0.48982322
78MP0005058_abnormal_lysosome_morphology0.48595725
79MP0005448_abnormal_energy_balance0.46595305
80MP0002249_abnormal_larynx_morphology0.46477130
81MP0002168_other_aberrant_phenotype0.46421022
82MP0000639_abnormal_adrenal_gland0.46360420
83MP0004147_increased_porphyrin_level0.45511905
84MP0002282_abnormal_trachea_morphology0.45269005
85MP0009785_altered_susceptibility_to0.44958596
86MP0003724_increased_susceptibility_to0.43720789
87MP0003953_abnormal_hormone_level0.43058556
88MP0008874_decreased_physiological_sensi0.42032099
89MP0000678_abnormal_parathyroid_gland0.40504433
90MP0005167_abnormal_blood-brain_barrier0.40417452
91MP0008873_increased_physiological_sensi0.39840947
92MP0005464_abnormal_platelet_physiology0.39794357
93MP0005166_decreased_susceptibility_to0.39178080
94MP0003075_altered_response_to0.38454268
95MP0002796_impaired_skin_barrier0.38368847
96MP0002822_catalepsy0.37298448
97MP0003718_maternal_effect0.37050083
98MP0009672_abnormal_birth_weight0.36617122
99MP0000538_abnormal_urinary_bladder0.36537081
100MP0004782_abnormal_surfactant_physiolog0.35712704
101MP0008872_abnormal_physiological_respon0.35666463
102MP0002837_dystrophic_cardiac_calcinosis0.34850834
103MP0009384_cardiac_valve_regurgitation0.34595125
104MP0009780_abnormal_chondrocyte_physiolo0.33635646
105MP0004381_abnormal_hair_follicle0.33275757
106* MP0002135_abnormal_kidney_morphology0.33099777
107MP0004883_abnormal_blood_vessel0.33072796
108MP0002909_abnormal_adrenal_gland0.32733293
109MP0003436_decreased_susceptibility_to0.31926024
110MP0009115_abnormal_fat_cell0.30371222
111MP0005164_abnormal_response_to0.30342462
112MP0004264_abnormal_extraembryonic_tissu0.29420159
113MP0006082_CNS_inflammation0.28868043
114MP0001845_abnormal_inflammatory_respons0.28025925
115MP0000579_abnormal_nail_morphology0.27886433
116MP0002970_abnormal_white_adipose0.27319564
117MP0003300_gastrointestinal_ulcer0.27227807
118MP0005187_abnormal_penis_morphology0.27123345
119MP0005248_abnormal_Harderian_gland0.26448379
120MP0003959_abnormal_lean_body0.26097548
121MP0000249_abnormal_blood_vessel0.25084535
122MP0003878_abnormal_ear_physiology0.23330633
123MP0005377_hearing/vestibular/ear_phenot0.23330633
124MP0005551_abnormal_eye_electrophysiolog0.22640016
125MP0003866_abnormal_defecation0.21808362
126MP0005023_abnormal_wound_healing0.21220528

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.17603483
2Intrahepatic cholestasis (HP:0001406)6.96569321
3Deep venous thrombosis (HP:0002625)6.65827061
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.34041356
5Prolonged partial thromboplastin time (HP:0003645)5.80822396
6Hypobetalipoproteinemia (HP:0003563)5.75243996
7* Xanthomatosis (HP:0000991)5.60081291
8Hyperlipoproteinemia (HP:0010980)4.96501336
9Complement deficiency (HP:0004431)4.93590196
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.82752515
11Hyperammonemia (HP:0001987)4.67809505
12Hyperglycinemia (HP:0002154)4.64246251
13Hyperglycinuria (HP:0003108)4.62724527
14Ketosis (HP:0001946)4.56323835
15Abnormality of serine family amino acid metabolism (HP:0010894)4.42059772
16Abnormality of glycine metabolism (HP:0010895)4.42059772
17Joint hemorrhage (HP:0005261)4.38321409
18Abnormality of aspartate family amino acid metabolism (HP:0010899)4.35976938
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.31973108
20Hypolipoproteinemia (HP:0010981)4.27548178
21Epidermoid cyst (HP:0200040)4.18990813
22Abnormality of the common coagulation pathway (HP:0010990)3.99681174
23Abnormality of methionine metabolism (HP:0010901)3.96724984
24Fat malabsorption (HP:0002630)3.92155522
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.90238186
26Hypoglycemic coma (HP:0001325)3.74679573
27Hypoalphalipoproteinemia (HP:0003233)3.72975794
28Nephritis (HP:0000123)3.72700040
29Abnormality of pyrimidine metabolism (HP:0004353)3.69739478
30Abnormality of fatty-acid metabolism (HP:0004359)3.64962080
31Abnormality of complement system (HP:0005339)3.56077610
32Conjugated hyperbilirubinemia (HP:0002908)3.54333379
33Ketoacidosis (HP:0001993)3.51097743
34Abnormality of the intrinsic pathway (HP:0010989)3.35368871
35Delayed CNS myelination (HP:0002188)3.34968708
36* Abnormality of nucleobase metabolism (HP:0010932)3.26170381
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24876291
38Hypercholesterolemia (HP:0003124)3.22130432
39Hyperbilirubinemia (HP:0002904)3.20378277
40Abnormality of serum amino acid levels (HP:0003112)3.15692976
41* Abnormality of purine metabolism (HP:0004352)3.03348474
42Metabolic acidosis (HP:0001942)2.99393412
43Steatorrhea (HP:0002570)2.90766520
44Vascular calcification (HP:0004934)2.89536561
45Dicarboxylic aciduria (HP:0003215)2.80469635
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.80469635
47Alkalosis (HP:0001948)2.79670670
48Lethargy (HP:0001254)2.78401512
49Proximal tubulopathy (HP:0000114)2.75324540
50Generalized aminoaciduria (HP:0002909)2.75064306
51Myocardial infarction (HP:0001658)2.68418344
52Potter facies (HP:0002009)2.67776321
53Facial shape deformation (HP:0011334)2.67776321
54Spontaneous abortion (HP:0005268)2.61767968
55Purpura (HP:0000979)2.60121874
56Widely patent fontanelles and sutures (HP:0004492)2.60093405
57Malnutrition (HP:0004395)2.59729616
58Systemic lupus erythematosus (HP:0002725)2.58876818
59Cardiovascular calcification (HP:0011915)2.56814288
60Hypochromic microcytic anemia (HP:0004840)2.56638261
61Skin nodule (HP:0200036)2.56407614
62Osteomalacia (HP:0002749)2.54725812
63Spastic diplegia (HP:0001264)2.53487462
64* Gout (HP:0001997)2.53028162
65Irritability (HP:0000737)2.52164872
66Neonatal onset (HP:0003623)2.50937821
67* Hepatocellular carcinoma (HP:0001402)2.49755240
68Abnormality of vitamin metabolism (HP:0100508)2.47295926
69Cerebral edema (HP:0002181)2.44495114
70Hydroxyprolinuria (HP:0003080)2.38350632
71Abnormality of proline metabolism (HP:0010907)2.38350632
72Vomiting (HP:0002013)2.36668439
73Rickets (HP:0002748)2.33432846
74Mitral stenosis (HP:0001718)2.31556539
75Hypoglycemic seizures (HP:0002173)2.31171790
76Sensorimotor neuropathy (HP:0007141)2.30961303
77Hyperphosphaturia (HP:0003109)2.30412606
78Glycosuria (HP:0003076)2.28197651
79Abnormality of urine glucose concentration (HP:0011016)2.28197651
80Acanthocytosis (HP:0001927)2.27588749
81Poikilocytosis (HP:0004447)2.25039109
82Abnormal gallbladder morphology (HP:0012437)2.23422794
83Glomerulonephritis (HP:0000099)2.20659099
84Cholelithiasis (HP:0001081)2.18702753
85Late onset (HP:0003584)2.18465300
86Cholecystitis (HP:0001082)2.17035975
87Abnormal gallbladder physiology (HP:0012438)2.17035975
88Abnormal enzyme/coenzyme activity (HP:0012379)2.14723339
89Recurrent gram-negative bacterial infections (HP:0005420)2.11791649
90Pulmonary embolism (HP:0002204)2.09886508
91Esophageal varix (HP:0002040)2.08830963
92Abnormal urine phosphate concentration (HP:0012599)2.08052672
93Pigmentary retinal degeneration (HP:0001146)2.07614378
94Hypophosphatemic rickets (HP:0004912)2.01317852
95Brushfield spots (HP:0001088)1.99908810
96Opisthotonus (HP:0002179)1.99362246
97* Increased purine levels (HP:0004368)1.98139960
98* Hyperuricemia (HP:0002149)1.98139960
99Hypophosphatemia (HP:0002148)1.97541579
100* Pancreatitis (HP:0001733)1.96421182
101Amyloidosis (HP:0011034)1.96367096
102Thrombophlebitis (HP:0004418)1.95423549
103Menorrhagia (HP:0000132)1.92883428
104Arthropathy (HP:0003040)1.92468964
105Abnormal cartilage morphology (HP:0002763)1.91586822
106Abnormality of alkaline phosphatase activity (HP:0004379)1.90963578
107Megaloblastic anemia (HP:0001889)1.90842481
108Abnormality of the gallbladder (HP:0005264)1.87834027
109Elevated alkaline phosphatase (HP:0003155)1.87807965
110Confusion (HP:0001289)1.86513259
111Fair hair (HP:0002286)1.86224466
112Hyperinsulinemic hypoglycemia (HP:0000825)1.85566794
113Hemorrhage of the eye (HP:0011885)1.84607110
114Joint swelling (HP:0001386)1.83618311
115Gingival bleeding (HP:0000225)1.83393953
116Renal cortical cysts (HP:0000803)1.81984026
117Hypokalemic alkalosis (HP:0001949)1.81037936
118Ileus (HP:0002595)1.70192804
119Epistaxis (HP:0000421)1.66230312
120Gangrene (HP:0100758)1.64948946
121Bifid scrotum (HP:0000048)1.64021167
122Increased serum ferritin (HP:0003281)1.63163432
123Reduced antithrombin III activity (HP:0001976)1.62936966
124Abnormality of transition element cation homeostasis (HP:0011030)1.60728255
125Wide cranial sutures (HP:0010537)1.60642599
126Abnormal tarsal ossification (HP:0008369)1.59890111
127* Nephrolithiasis (HP:0000787)1.59748498
128Abnormality of iron homeostasis (HP:0011031)1.59018420
129Cerebral palsy (HP:0100021)1.58355176
130Abnormality of the Achilles tendon (HP:0005109)1.56686735
131Abnormality of the vitamin B12 metabolism (HP:0004341)1.55314794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.10315719
2FGFR44.28922227
3ERN13.93356159
4SIK13.88949295
5ACVR1B3.76016061
6WNK42.83042606
7WNK32.79129864
8INSRR2.77722699
9ERBB42.77202992
10TAOK32.64278818
11PIK3CA2.51295176
12OXSR12.36626909
13MST1R2.20118018
14MAP2K42.03488823
15AKT31.95830499
16MAPK111.86657067
17PKN21.84742598
18NTRK31.76516050
19PRKG21.61577271
20STK38L1.57324207
21PIK3CG1.53636000
22FLT31.52911945
23LATS11.52855671
24TRIB31.51840111
25MAP3K21.48594794
26ABL21.43956801
27TYK21.42327182
28PTK61.38939821
29FRK1.38644028
30EPHA21.35425929
31DAPK21.33985146
32PINK11.32643388
33MAP3K71.26990497
34FGFR11.21684636
35NEK91.20561697
36FGFR21.17170986
37PRKAA21.13386284
38GRK61.12821243
39JAK21.11349605
40KDR1.08191353
41TYRO31.05801746
42PDGFRA1.03387769
43SGK2230.99377083
44SGK4940.99377083
45DDR20.96341414
46STK390.95901281
47MAPK150.94945141
48ERBB20.94594386
49NLK0.94435799
50SGK30.93724928
51EPHB10.92634442
52MAP3K140.91491186
53MAP2K30.90335396
54PRKCZ0.88465337
55TIE10.87673190
56MAP3K30.87062227
57WNK10.86440959
58GSK3A0.85908050
59MAPK40.85645651
60TBK10.83431475
61PDK30.83122162
62PDK40.83122162
63MAP3K100.82664032
64JAK10.82488077
65SGK20.82155263
66MET0.81671688
67DYRK1B0.79308691
68PRKAA10.77591044
69BCR0.74624759
70MAPK120.73033584
71PRKACG0.71907533
72MATK0.69453829
73PRKG10.67152921
74IRAK30.64985366
75TGFBR20.64007559
76PRKACA0.63473562
77PTK20.63436725
78SGK10.62873595
79CAMK2G0.61235148
80MAPKAPK30.61223082
81MAP3K110.61119095
82CDK60.60030356
83CSK0.59763847
84RIPK10.59113921
85FER0.58777669
86PDPK10.57454230
87BRSK20.56621388
88SIK20.55839456
89MAP2K60.53373875
90CAMK1D0.52908964
91NEK10.52851405
92SRC0.51506708
93CDC42BPA0.49626495
94CAMKK20.49097419
95CSNK1E0.48707145
96EPHA30.48370447
97PDK20.45280351
98MAPK70.45065386
99CSNK1G10.44654367
100PRKCQ0.44554775
101CDK120.42883718
102STK380.42134265
103FGFR30.41484064
104RPS6KB10.39950986
105CSF1R0.39697184
106CASK0.38224790
107IGF1R0.37341795
108IKBKE0.36781748
109TNIK0.36150973
110ITK0.35571248
111PDK10.35436437
112EPHA40.35393644
113GRK10.35070997
114PRKCB0.34815650
115PKN10.34660983
116MAP4K20.34536930
117PRKCG0.34457806
118LMTK20.33852543
119RPS6KA30.33480231
120ADRBK20.33227055
121MTOR0.32406398
122CSNK1D0.32262495
123FGR0.31818800
124MAP2K10.30676093
125MAPK30.29734065
126MAP3K50.29426072
127IRAK20.29151359
128ICK0.28760937
129MAP3K130.28675614
130RET0.27503934
131PAK30.27220389
132CAMK40.27013698
133EGFR0.26852668
134MAP3K60.26288366
135PRKCA0.26070075
136CSNK1A10.26043844
137PRKACB0.25439488
138CDK40.23570145
139IRAK10.23350914
140BMX0.23062364
141MAP3K10.21929784

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30017569
2Nitrogen metabolism_Homo sapiens_hsa009103.43159008
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.41751072
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40925441
5Arginine biosynthesis_Homo sapiens_hsa002202.91628483
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.79406465
7Tryptophan metabolism_Homo sapiens_hsa003802.72601698
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62884599
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.57600479
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55028125
11Fatty acid degradation_Homo sapiens_hsa000712.54163209
12Complement and coagulation cascades_Homo sapiens_hsa046102.48873681
13Butanoate metabolism_Homo sapiens_hsa006502.40311570
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.37147353
15Peroxisome_Homo sapiens_hsa041462.21270228
16Propanoate metabolism_Homo sapiens_hsa006402.13952494
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01672481
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.88588665
19PPAR signaling pathway_Homo sapiens_hsa033201.85640096
20Fatty acid metabolism_Homo sapiens_hsa012121.84863373
21Histidine metabolism_Homo sapiens_hsa003401.84377044
22Chemical carcinogenesis_Homo sapiens_hsa052041.80644444
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.80136683
24beta-Alanine metabolism_Homo sapiens_hsa004101.77824256
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77361534
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71693373
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70588810
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65511437
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.65217058
30Selenocompound metabolism_Homo sapiens_hsa004501.58183926
31Retinol metabolism_Homo sapiens_hsa008301.58005649
32Bile secretion_Homo sapiens_hsa049761.57369965
33Phenylalanine metabolism_Homo sapiens_hsa003601.56503324
34Pyruvate metabolism_Homo sapiens_hsa006201.53884225
35Staphylococcus aureus infection_Homo sapiens_hsa051501.52629050
36Caffeine metabolism_Homo sapiens_hsa002321.51733735
37Sulfur metabolism_Homo sapiens_hsa009201.42924398
38Tyrosine metabolism_Homo sapiens_hsa003501.35934855
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34604814
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.34203338
41Fatty acid elongation_Homo sapiens_hsa000621.31764529
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.29954541
43Folate biosynthesis_Homo sapiens_hsa007901.24535348
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23496051
45Carbon metabolism_Homo sapiens_hsa012001.23385780
46Biosynthesis of amino acids_Homo sapiens_hsa012301.21711771
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19139648
48* Starch and sucrose metabolism_Homo sapiens_hsa005001.14913164
49ABC transporters_Homo sapiens_hsa020101.13489464
50Steroid biosynthesis_Homo sapiens_hsa001001.12448144
51Vitamin digestion and absorption_Homo sapiens_hsa049771.05793847
52Arginine and proline metabolism_Homo sapiens_hsa003301.03753934
53Fat digestion and absorption_Homo sapiens_hsa049751.02583048
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.00153523
55Lysine degradation_Homo sapiens_hsa003100.90644303
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87707048
57Sulfur relay system_Homo sapiens_hsa041220.87674989
58Vitamin B6 metabolism_Homo sapiens_hsa007500.83765778
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81860631
60Glutathione metabolism_Homo sapiens_hsa004800.78126322
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.76584564
62Glycerolipid metabolism_Homo sapiens_hsa005610.72596857
63One carbon pool by folate_Homo sapiens_hsa006700.69453495
64* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68766158
65Pentose phosphate pathway_Homo sapiens_hsa000300.59373301
66* Metabolic pathways_Homo sapiens_hsa011000.48102709
67Fatty acid biosynthesis_Homo sapiens_hsa000610.43620027
68Pertussis_Homo sapiens_hsa051330.36275299
69Fructose and mannose metabolism_Homo sapiens_hsa000510.33316630
70Prion diseases_Homo sapiens_hsa050200.27812526
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26643907
72* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23455708
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21996347
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21016943
75* Insulin resistance_Homo sapiens_hsa049310.16855064
76Sphingolipid metabolism_Homo sapiens_hsa006000.14224679
77* Adipocytokine signaling pathway_Homo sapiens_hsa049200.12607939
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.11830635
79Linoleic acid metabolism_Homo sapiens_hsa005910.10983142
80Ether lipid metabolism_Homo sapiens_hsa005650.09737755
81* Glucagon signaling pathway_Homo sapiens_hsa049220.03121013
82* Galactose metabolism_Homo sapiens_hsa000520.01242021
83N-Glycan biosynthesis_Homo sapiens_hsa005100.01068474
84Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.2217049
85African trypanosomiasis_Homo sapiens_hsa05143-0.2213062
86Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2109525
87Bladder cancer_Homo sapiens_hsa05219-0.2051468
88Other glycan degradation_Homo sapiens_hsa00511-0.1962736
89Lysosome_Homo sapiens_hsa04142-0.1938337
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1834254
91Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1746317
92* Insulin signaling pathway_Homo sapiens_hsa04910-0.1641990
93Hepatitis C_Homo sapiens_hsa05160-0.1630578
94Regulation of autophagy_Homo sapiens_hsa04140-0.1308987
95Circadian rhythm_Homo sapiens_hsa04710-0.1271535
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1266318
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1209717
98Amoebiasis_Homo sapiens_hsa05146-0.1131556
99Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1086427
100Mineral absorption_Homo sapiens_hsa04978-0.1028463
101Protein digestion and absorption_Homo sapiens_hsa04974-0.1007779
102Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1005913
103Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0959309
104Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0709195
105Serotonergic synapse_Homo sapiens_hsa04726-0.0525318
106Renin-angiotensin system_Homo sapiens_hsa04614-0.0475935
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0329030
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0294623
109* AMPK signaling pathway_Homo sapiens_hsa04152-0.0290466

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