FZD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1outer ear morphogenesis (GO:0042473)5.63791766
2paraxial mesoderm development (GO:0048339)5.03661672
3* planar cell polarity pathway involved in neural tube closure (GO:0090179)4.80627498
4bone trabecula formation (GO:0060346)4.70564886
5chondrocyte proliferation (GO:0035988)4.53084916
6* regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.45961073
7metanephric mesenchyme development (GO:0072075)4.43795027
8kidney mesenchyme development (GO:0072074)4.42423441
9protein heterotrimerization (GO:0070208)4.37392254
10lateral sprouting from an epithelium (GO:0060601)4.24215489
11middle ear morphogenesis (GO:0042474)4.22053360
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.15986645
13heterochromatin organization (GO:0070828)4.06793083
14collagen fibril organization (GO:0030199)4.06149477
15neuron projection extension involved in neuron projection guidance (GO:1902284)4.05226811
16axon extension involved in axon guidance (GO:0048846)4.05226811
17cell proliferation involved in metanephros development (GO:0072203)4.03599482
18hippo signaling (GO:0035329)3.86575804
19proximal/distal pattern formation (GO:0009954)3.74486953
20sequestering of extracellular ligand from receptor (GO:0035581)3.72751852
21embryonic skeletal joint morphogenesis (GO:0060272)3.66669018
22embryonic cranial skeleton morphogenesis (GO:0048701)3.64188575
23craniofacial suture morphogenesis (GO:0097094)3.63874409
24regulation of heart morphogenesis (GO:2000826)3.61462684
25mesenchymal cell proliferation (GO:0010463)3.59585433
26notochord development (GO:0030903)3.54931963
27polarized epithelial cell differentiation (GO:0030859)3.54475694
28negative regulation of chondrocyte differentiation (GO:0032331)3.54011796
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50416369
30mesenchyme morphogenesis (GO:0072132)3.44408757
31heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.44169805
32* G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.40920632
33pattern specification involved in kidney development (GO:0061004)3.40759679
34negative regulation of catenin import into nucleus (GO:0035414)3.32707225
35positive regulation of gastrulation (GO:2000543)3.30341185
36* cochlea morphogenesis (GO:0090103)3.28861860
37* Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.27998096
38cell migration involved in heart development (GO:0060973)3.26448935
39lens fiber cell development (GO:0070307)3.25631843
40convergent extension (GO:0060026)3.24085212
41mesenchyme development (GO:0060485)3.23237738
42negative regulation of embryonic development (GO:0045992)3.22890434
43mesenchymal-epithelial cell signaling (GO:0060638)3.22613050
44cell proliferation involved in kidney development (GO:0072111)3.18893556
45positive regulation of epithelial to mesenchymal transition (GO:0010718)3.14696611
46* regulation of establishment of planar polarity (GO:0090175)3.14451090
47* non-canonical Wnt signaling pathway (GO:0035567)3.13664077
48dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13105083
49positive regulation of mesenchymal cell proliferation (GO:0002053)3.10865888
50epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.10831432
51hindlimb morphogenesis (GO:0035137)3.10594396
52organ induction (GO:0001759)3.08962916
53establishment of planar polarity (GO:0001736)3.08897721
54establishment of tissue polarity (GO:0007164)3.08897721
55embryonic forelimb morphogenesis (GO:0035115)3.04483460
56glomerular basement membrane development (GO:0032836)3.03806804
57negative regulation of cartilage development (GO:0061037)3.02203458
58heparan sulfate proteoglycan metabolic process (GO:0030201)3.01246769
59lung-associated mesenchyme development (GO:0060484)3.00702653
60collagen catabolic process (GO:0030574)2.99699653
61protein retention in ER lumen (GO:0006621)2.99411767
62tooth mineralization (GO:0034505)2.99290214
63endodermal cell differentiation (GO:0035987)2.99254399
64embryonic hindlimb morphogenesis (GO:0035116)2.98796852
65cranial suture morphogenesis (GO:0060363)2.97639342
66positive regulation of smoothened signaling pathway (GO:0045880)2.97392239
67body morphogenesis (GO:0010171)2.96470253
68regulation of mesenchymal cell proliferation (GO:0010464)2.95406656
69mesenchymal to epithelial transition (GO:0060231)2.95169699
70establishment or maintenance of monopolar cell polarity (GO:0061339)2.94559266
71establishment of monopolar cell polarity (GO:0061162)2.94559266
72establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.93804172
73basement membrane organization (GO:0071711)2.92930081
74atrial septum morphogenesis (GO:0060413)2.92810576
75negative regulation of osteoblast proliferation (GO:0033689)2.91129606
76multicellular organismal macromolecule metabolic process (GO:0044259)2.89907151
77forelimb morphogenesis (GO:0035136)2.87570249
78camera-type eye morphogenesis (GO:0048593)2.87434642
79regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.86017321
80regulation of organ formation (GO:0003156)2.85502220
81anatomical structure regression (GO:0060033)2.85379946
82maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.81200196
83dermatan sulfate biosynthetic process (GO:0030208)2.79858064
84regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.78893724
85ventricular cardiac muscle cell development (GO:0055015)2.78384436
86regulation of hippo signaling (GO:0035330)2.77875491
87embryonic skeletal system morphogenesis (GO:0048704)2.77859640
88regulation of gastrulation (GO:0010470)2.77818162
89head development (GO:0060322)2.77243184
90positive regulation of cartilage development (GO:0061036)2.75085880
91endocardial cushion morphogenesis (GO:0003203)2.73344970
92adherens junction assembly (GO:0034333)2.73104032
93cellular response to vitamin (GO:0071295)2.71561011
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71441312
95endothelial cell morphogenesis (GO:0001886)2.70112081
96cell migration involved in sprouting angiogenesis (GO:0002042)2.69678920
97embryonic camera-type eye development (GO:0031076)2.69397764
98negative regulation of axon extension involved in axon guidance (GO:0048843)2.69241088
99skin morphogenesis (GO:0043589)2.68714931
100regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.68400304
101renal system development (GO:0072001)2.68005241
102regulation of cartilage development (GO:0061035)2.67865751
103regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.67706696
104establishment or maintenance of apical/basal cell polarity (GO:0035088)2.67452976
105establishment or maintenance of bipolar cell polarity (GO:0061245)2.67452976
106mesenchymal cell differentiation involved in kidney development (GO:0072161)2.67116594
107mesenchymal cell differentiation involved in renal system development (GO:2001012)2.67116594
108multicellular organismal catabolic process (GO:0044243)2.66822039
109embryonic digit morphogenesis (GO:0042733)2.66742286
110multicellular organismal metabolic process (GO:0044236)2.66615824
111branching involved in salivary gland morphogenesis (GO:0060445)2.65232885
112establishment of apical/basal cell polarity (GO:0035089)2.64954224
113appendage morphogenesis (GO:0035107)2.64669594
114limb morphogenesis (GO:0035108)2.64669594
115negative regulation of fatty acid transport (GO:2000192)2.64330447
116cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64009790
117mitotic chromosome condensation (GO:0007076)2.63898919
118endocardial cushion development (GO:0003197)2.63885160
119collagen metabolic process (GO:0032963)2.63690253
120regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.63272572
121embryonic limb morphogenesis (GO:0030326)2.62330169
122embryonic appendage morphogenesis (GO:0035113)2.62330169
123chondrocyte development (GO:0002063)2.62146684
124eye morphogenesis (GO:0048592)2.61960758
125cellular response to vitamin D (GO:0071305)2.60998712
126somatic stem cell division (GO:0048103)2.60808329
127proteoglycan metabolic process (GO:0006029)2.60005980
128urogenital system development (GO:0001655)2.59787294
129artery development (GO:0060840)2.59324680
130negative regulation of fibroblast apoptotic process (GO:2000270)2.58551060
131epithelial to mesenchymal transition (GO:0001837)2.58077317
132neural crest cell development (GO:0014032)2.57884306
133regulation of cell fate specification (GO:0042659)2.57785253
134embryonic skeletal system development (GO:0048706)2.56941816
135gastrulation with mouth forming second (GO:0001702)2.56792387
136cartilage morphogenesis (GO:0060536)2.56141108
137type B pancreatic cell proliferation (GO:0044342)2.55506459
138glial cell migration (GO:0008347)2.55208787
139regulation of chondrocyte differentiation (GO:0032330)2.51350819
140cell adhesion mediated by integrin (GO:0033627)2.49789545
141midgut development (GO:0007494)2.48778132
142axon extension (GO:0048675)2.47017499
143focal adhesion assembly (GO:0048041)2.45807544
144cell-substrate adherens junction assembly (GO:0007045)2.45807544
145negative regulation of DNA repair (GO:0045738)2.44054812
146positive regulation of chondrocyte differentiation (GO:0032332)2.42711715
147adhesion of symbiont to host cell (GO:0044650)2.42520526
148virion attachment to host cell (GO:0019062)2.42520526
149negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.42435879
150radial glial cell differentiation (GO:0060019)2.41902077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.95835267
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.98484196
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.31488390
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.28986884
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.10077073
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98702703
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96106065
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93015133
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.70375132
10* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.58714298
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.56702869
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.44611618
13WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.43360614
14E2F7_22180533_ChIP-Seq_HELA_Human2.42264925
15* TP53_20018659_ChIP-ChIP_R1E_Mouse2.40536550
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.34130598
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.19241352
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17685833
19* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.16915234
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09053579
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.04019779
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.95129357
23CLOCK_20551151_ChIP-Seq_293T_Human1.93679287
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.83810161
25HIF1A_21447827_ChIP-Seq_MCF-7_Human1.82631267
26* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82246191
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.80613988
28* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79320863
29* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79320863
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78829552
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76502852
32* ISL1_27105846_Chip-Seq_CPCs_Mouse1.76126161
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73243482
34* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72582758
35* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.71141393
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61381340
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60361144
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58423244
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57650230
40* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57241504
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.55219620
42LXR_22292898_ChIP-Seq_THP-1_Human1.54093630
43* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52405637
44* RING1B_27294783_Chip-Seq_NPCs_Mouse1.52178714
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.52160441
46* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51279437
47* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.50310698
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49385223
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45979822
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43840526
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43560356
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43474194
53BRD4_25478319_ChIP-Seq_HGPS_Human1.42367224
54* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42087013
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.40711353
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40032084
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39785540
58SMC3_22415368_ChIP-Seq_MEFs_Mouse1.39245537
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37848056
60CBX2_27304074_Chip-Seq_ESCs_Mouse1.37766011
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36825859
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36825859
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36825859
64AR_21909140_ChIP-Seq_LNCAP_Human1.35815041
65* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.33570849
66* RNF2_27304074_Chip-Seq_ESCs_Mouse1.32651426
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.30558571
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.30503400
69* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30180196
70* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.30119957
71* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29687303
72* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29598805
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.28958115
74* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28693755
75* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28406461
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28142160
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27717012
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25511628
79SA1_22415368_ChIP-Seq_MEFs_Mouse1.25253833
80* NANOG_16153702_ChIP-ChIP_HESCs_Human1.24730648
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.24618897
82* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.23554113
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.22295473
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21158707
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20034806
86* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19917270
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.19621253
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19005408
89* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18499658
90ERG_21242973_ChIP-ChIP_JURKAT_Human1.17679264
91* SOX2_16153702_ChIP-ChIP_HESCs_Human1.17528687
92* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.17507738
93* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17481114
94MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16427937
95* NANOG_21062744_ChIP-ChIP_HESCs_Human1.16171446
96KDM2B_26808549_Chip-Seq_JURKAT_Human1.15998617
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15748246
98* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14538922
99MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14190149
100TP53_22127205_ChIP-Seq_IMR90_Human1.14134044
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12373714
102* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11641952
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11629496
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11358872
105NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10523390
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10428803
107RACK7_27058665_Chip-Seq_MCF-7_Human1.10008669
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08043996
109KDM2B_26808549_Chip-Seq_K562_Human1.07987279
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07708817
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07494500
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05520938
113* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05487807
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04862256
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04611972
116NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04104569
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02387724
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.01908760
119SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.01908760
120CJUN_26792858_Chip-Seq_BT549_Human1.01789287
121XRN2_22483619_ChIP-Seq_HELA_Human1.01386730
122ATF3_27146783_Chip-Seq_COLON_Human1.00075130
123SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99829181
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97583586
125TP53_23651856_ChIP-Seq_MEFs_Mouse0.96215730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.57662967
2MP0010030_abnormal_orbit_morphology4.20568127
3MP0005503_abnormal_tendon_morphology3.60634653
4MP0003705_abnormal_hypodermis_morpholog3.00184336
5MP0009053_abnormal_anal_canal2.88124551
6MP0005275_abnormal_skin_tensile2.73496703
7MP0003385_abnormal_body_wall2.70467282
8MP0000049_abnormal_middle_ear2.52219480
9MP0005623_abnormal_meninges_morphology2.51445633
10MP0009250_abnormal_appendicular_skeleto2.48039241
11MP0002249_abnormal_larynx_morphology2.47767936
12MP0006292_abnormal_olfactory_placode2.42329740
13MP0000537_abnormal_urethra_morphology2.36856126
14MP0003942_abnormal_urinary_system2.34797177
15MP0003941_abnormal_skin_development2.16249474
16MP0004272_abnormal_basement_membrane2.14780695
17MP0003279_aneurysm2.14136209
18MP0000428_abnormal_craniofacial_morphol2.10408626
19MP0005508_abnormal_skeleton_morphology2.00945408
20MP0000534_abnormal_ureter_morphology1.96967606
21MP0003937_abnormal_limbs/digits/tail_de1.93293198
22MP0002932_abnormal_joint_morphology1.90731367
23MP0009384_cardiac_valve_regurgitation1.90503547
24MP0000566_synostosis1.89987025
25MP0004858_abnormal_nervous_system1.82141274
26MP0003123_paternal_imprinting1.82081322
27MP0002282_abnormal_trachea_morphology1.80672257
28* MP0003755_abnormal_palate_morphology1.79244021
29MP0005257_abnormal_intraocular_pressure1.75293514
30MP0001958_emphysema1.73448445
31MP0006054_spinal_hemorrhage1.72638208
32MP0003122_maternal_imprinting1.68699710
33MP0000733_abnormal_muscle_development1.63221416
34MP0003115_abnormal_respiratory_system1.61348674
35MP0002233_abnormal_nose_morphology1.60734324
36MP0001542_abnormal_bone_strength1.59509997
37MP0000762_abnormal_tongue_morphology1.57216095
38MP0003935_abnormal_craniofacial_develop1.55239355
39MP0002116_abnormal_craniofacial_bone1.52410046
40MP0001299_abnormal_eye_distance/1.47292256
41MP0000432_abnormal_head_morphology1.43026357
42MP0003283_abnormal_digestive_organ1.41992759
43MP0000516_abnormal_urinary_system1.37473472
44MP0005367_renal/urinary_system_phenotyp1.37473472
45MP0005076_abnormal_cell_differentiation1.35258699
46MP0005197_abnormal_uvea_morphology1.33599944
47MP0002060_abnormal_skin_morphology1.31051835
48MP0002234_abnormal_pharynx_morphology1.29480341
49MP0000163_abnormal_cartilage_morphology1.28899214
50MP0002938_white_spotting1.28784926
51MP0002111_abnormal_tail_morphology1.28012282
52MP0002109_abnormal_limb_morphology1.27658262
53MP0003119_abnormal_digestive_system1.26860768
54MP0000751_myopathy1.26265942
55MP0009379_abnormal_foot_pigmentation1.24662181
56MP0003938_abnormal_ear_development1.24355877
57MP0001293_anophthalmia1.24023258
58MP0002108_abnormal_muscle_morphology1.23584485
59MP0002653_abnormal_ependyma_morphology1.20527834
60MP0002115_abnormal_skeleton_extremities1.19595796
61MP0002114_abnormal_axial_skeleton1.17856160
62MP0003566_abnormal_cell_adhesion1.17392596
63MP0000678_abnormal_parathyroid_gland1.16055784
64MP0002697_abnormal_eye_size1.14662043
65MP0002295_abnormal_pulmonary_circulatio1.13348907
66MP0002177_abnormal_outer_ear1.11879211
67MP0001849_ear_inflammation1.11551932
68MP0002092_abnormal_eye_morphology1.09369136
69MP0002896_abnormal_bone_mineralization1.08985018
70MP0003121_genomic_imprinting1.07822475
71MP0000767_abnormal_smooth_muscle1.06814270
72MP0005248_abnormal_Harderian_gland1.06534052
73MP0008789_abnormal_olfactory_epithelium1.06336208
74* MP0002085_abnormal_embryonic_tissue1.05654643
75MP0000778_abnormal_nervous_system1.04148538
76MP0001286_abnormal_eye_development1.03534977
77MP0004197_abnormal_fetal_growth/weight/1.03088563
78MP0005023_abnormal_wound_healing1.03012970
79MP0003567_abnormal_fetal_cardiomyocyte1.00961107
80MP0002084_abnormal_developmental_patter0.99366606
81MP0002113_abnormal_skeleton_development0.99201275
82MP0003315_abnormal_perineum_morphology0.99036688
83MP0001340_abnormal_eyelid_morphology0.98979365
84MP0005193_abnormal_anterior_eye0.97960200
85MP0004233_abnormal_muscle_weight0.97110857
86MP0004134_abnormal_chest_morphology0.95480628
87MP0003091_abnormal_cell_migration0.94349353
88MP0010368_abnormal_lymphatic_system0.92925525
89MP0005394_taste/olfaction_phenotype0.92608970
90MP0005499_abnormal_olfactory_system0.92608970
91MP0001346_abnormal_lacrimal_gland0.90653181
92MP0008932_abnormal_embryonic_tissue0.88684011
93MP0002254_reproductive_system_inflammat0.88676205
94MP0000467_abnormal_esophagus_morphology0.88381936
95MP0010352_gastrointestinal_tract_polyps0.87769443
96MP0005187_abnormal_penis_morphology0.87358315
97MP0002925_abnormal_cardiovascular_devel0.85499793
98MP0000462_abnormal_digestive_system0.85485374
99MP0001243_abnormal_dermal_layer0.84960171
100MP0001270_distended_abdomen0.84150023
101MP0009672_abnormal_birth_weight0.82844009
102* MP0003861_abnormal_nervous_system0.81192575
103MP0008007_abnormal_cellular_replicative0.80634980
104MP0005377_hearing/vestibular/ear_phenot0.79717597
105MP0003878_abnormal_ear_physiology0.79717597
106MP0002089_abnormal_postnatal_growth/wei0.78368158
107MP0000750_abnormal_muscle_regeneration0.77846359
108MP0001879_abnormal_lymphatic_vessel0.77342021
109MP0001348_abnormal_lacrimal_gland0.76521731
110MP0000579_abnormal_nail_morphology0.75872545
111MP0003111_abnormal_nucleus_morphology0.74435494
112MP0004133_heterotaxia0.72941026
113* MP0002081_perinatal_lethality0.71965783
114MP0005390_skeleton_phenotype0.71784283
115MP0009703_decreased_birth_body0.71591524
116MP0002098_abnormal_vibrissa_morphology0.71487312
117MP0001175_abnormal_lung_morphology0.71043322
118MP0005171_absent_coat_pigmentation0.67094616

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.65920677
2Premature rupture of membranes (HP:0001788)5.44203640
3Shallow orbits (HP:0000586)4.71646893
4Short 4th metacarpal (HP:0010044)4.01166917
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.01166917
6Ankle contracture (HP:0006466)3.56685532
7Neonatal short-limb short stature (HP:0008921)3.34269190
8Broad metatarsal (HP:0001783)3.28828995
9Abnormality of the 4th metacarpal (HP:0010012)3.28109629
10Atrophic scars (HP:0001075)3.17342421
11Soft skin (HP:0000977)3.12761963
12Vascular tortuosity (HP:0004948)3.11728469
13Abnormality of dentin (HP:0010299)3.11165286
14Coronal craniosynostosis (HP:0004440)3.09702334
15Aortic dissection (HP:0002647)3.09583635
16Bladder diverticulum (HP:0000015)3.07586826
17Renal duplication (HP:0000075)3.02172193
18Fragile skin (HP:0001030)3.01663862
19Partial duplication of thumb phalanx (HP:0009944)2.97295494
20Arterial tortuosity (HP:0005116)2.87258311
21Hyperacusis (HP:0010780)2.67242573
22Deviation of the hallux (HP:0010051)2.61538000
23Broad toe (HP:0001837)2.52428009
24Selective tooth agenesis (HP:0001592)2.48679200
25Disproportionate tall stature (HP:0001519)2.46691271
26Peritonitis (HP:0002586)2.45958687
27Cerebral aneurysm (HP:0004944)2.45827112
28Hallux valgus (HP:0001822)2.44525768
29Morphological abnormality of the middle ear (HP:0008609)2.42758393
30Type 1 muscle fiber predominance (HP:0003803)2.41150535
31Genu recurvatum (HP:0002816)2.40082295
32Dilatation of the ascending aorta (HP:0005111)2.36699784
33Mitral valve prolapse (HP:0001634)2.34781107
34Mesomelia (HP:0003027)2.34546894
35Blue sclerae (HP:0000592)2.34529781
36Abnormality of the parietal bone (HP:0002696)2.33386135
37Wide anterior fontanel (HP:0000260)2.33229351
38Aortic aneurysm (HP:0004942)2.27428913
39Thin ribs (HP:0000883)2.24098559
40Down-sloping shoulders (HP:0200021)2.22264266
41Biconcave vertebral bodies (HP:0004586)2.21683980
42Broad long bones (HP:0005622)2.21107955
43Bowel diverticulosis (HP:0005222)2.20002350
44Abnormality of the phalanges of the hallux (HP:0010057)2.17354164
45Broad hallux (HP:0010055)2.16003000
46Broad thumb (HP:0011304)2.14777674
47Follicular hyperkeratosis (HP:0007502)2.13790956
48Slender build (HP:0001533)2.13775812
49Short middle phalanx of the 5th finger (HP:0004220)2.12895847
50Spinal rigidity (HP:0003306)2.11853119
51Cervical subluxation (HP:0003308)2.10843118
52Wormian bones (HP:0002645)2.08934488
53Wrist flexion contracture (HP:0001239)2.07320430
54Septo-optic dysplasia (HP:0100842)2.06083550
55Hypoventilation (HP:0002791)2.05285140
56Arnold-Chiari malformation (HP:0002308)2.05196309
57Asymmetry of the thorax (HP:0001555)2.01628808
58Short nail (HP:0001799)2.00968306
59Breech presentation (HP:0001623)2.00844277
60Abnormality of the distal phalanx of the thumb (HP:0009617)1.99196835
61Hyperextensible skin (HP:0000974)1.97619075
62Microglossia (HP:0000171)1.96613236
63Camptodactyly of toe (HP:0001836)1.96583960
64Abnormality of the calcaneus (HP:0008364)1.96309247
65Buphthalmos (HP:0000557)1.95186389
66Bronchomalacia (HP:0002780)1.95162940
67Overriding aorta (HP:0002623)1.94973753
68Broad phalanx (HP:0006009)1.94452579
69Delayed cranial suture closure (HP:0000270)1.94323979
70Duplication of thumb phalanx (HP:0009942)1.93908082
71Bowed forearm bones (HP:0003956)1.93893817
72Bowing of the arm (HP:0006488)1.93893817
73Spinal cord lesions (HP:0100561)1.93495141
74Syringomyelia (HP:0003396)1.93495141
75Preaxial foot polydactyly (HP:0001841)1.93337286
76Abnormal number of incisors (HP:0011064)1.92598981
77Elbow flexion contracture (HP:0002987)1.92587534
78Broad phalanges of the hand (HP:0009768)1.92447880
79Turricephaly (HP:0000262)1.91639580
80Partial duplication of the phalanx of hand (HP:0009999)1.90171859
81Broad finger (HP:0001500)1.89876917
82Short 5th finger (HP:0009237)1.89494236
83Midline defect of the nose (HP:0004122)1.88546433
84Ulnar bowing (HP:0003031)1.87563312
85Congenital glaucoma (HP:0001087)1.87237469
86Abnormality of the 2nd finger (HP:0004100)1.86932610
87Natal tooth (HP:0000695)1.86508934
88Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.86188161
89Ectopia lentis (HP:0001083)1.85651589
90Abnormality of the middle phalanges of the toes (HP:0010183)1.84728229
91Joint laxity (HP:0001388)1.84442164
92Flat cornea (HP:0007720)1.84051269
93Vertebral compression fractures (HP:0002953)1.83756188
94Mitral regurgitation (HP:0001653)1.83256145
95Spondylolisthesis (HP:0003302)1.82922455
96Overgrowth (HP:0001548)1.82303436
97Cutaneous finger syndactyly (HP:0010554)1.82040545
98Tarsal synostosis (HP:0008368)1.82029191
99Abnormal delivery (HP:0001787)1.81255229
100Vitreoretinal degeneration (HP:0000655)1.81118121
101Mildly elevated creatine phosphokinase (HP:0008180)1.80536938
102Midface retrusion (HP:0011800)1.79135497
103Aplasia involving bones of the upper limbs (HP:0009823)1.78481126
104Aplasia of the phalanges of the hand (HP:0009802)1.78481126
105Aplasia involving bones of the extremities (HP:0009825)1.78481126
106Hip contracture (HP:0003273)1.76794114
107Atresia of the external auditory canal (HP:0000413)1.74775016
108High anterior hairline (HP:0009890)1.74452418
109Broad face (HP:0000283)1.74135808
110Absent frontal sinuses (HP:0002688)1.73511490
111Broad distal phalanx of finger (HP:0009836)1.73419031
112Broad ribs (HP:0000885)1.72398974
113Chin dimple (HP:0010751)1.71082894
114Abnormality of the acetabulum (HP:0003170)1.70748901
115Abnormality of the peritoneum (HP:0002585)1.69802853
116Synostosis involving bones of the feet (HP:0009140)1.69543490
117Synostosis involving bones of the lower limbs (HP:0009138)1.69543490
118Synostosis of carpal bones (HP:0005048)1.69420630
119Increased variability in muscle fiber diameter (HP:0003557)1.69180592
120Elfin facies (HP:0004428)1.67653410
121Pterygium (HP:0001059)1.67612970
122Renovascular hypertension (HP:0100817)1.67552956
123Inguinal hernia (HP:0000023)1.66889682
124Thin bony cortex (HP:0002753)1.66866876
125Cutaneous syndactyly (HP:0012725)1.66702468
126Trigonocephaly (HP:0000243)1.66552178
127Long toe (HP:0010511)1.65533853
128Knee flexion contracture (HP:0006380)1.65473765
129Arachnodactyly (HP:0001166)1.65269594
130Increased connective tissue (HP:0009025)1.65080734
131Concave nail (HP:0001598)1.64225136
132Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64025815
133Abnormality of the radial head (HP:0003995)1.63692190
134Carpal synostosis (HP:0009702)1.62735374
135Infantile muscular hypotonia (HP:0008947)1.62543819
136Dislocated radial head (HP:0003083)1.62356274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.36796303
2LATS13.83536634
3TRIB33.78159761
4LATS23.74889017
5DDR23.61702699
6PDGFRA3.14143943
7MAP3K102.70622959
8TTN2.69386658
9PKN22.44312924
10MYLK2.43324301
11SMG12.37697123
12NTRK12.29378713
13VRK22.23712596
14SIK12.12155145
15TLK12.07369799
16MKNK11.94180167
17EPHA21.85799828
18EEF2K1.73481268
19FGFR11.72533316
20PAK41.66825659
21PAK21.65779928
22MKNK21.61102360
23ILK1.59313753
24PTK61.58767043
25BMX1.50198823
26STK38L1.48971991
27STK31.40359312
28CDK121.33750156
29RPS6KA41.26115466
30BUB11.24883500
31DMPK1.21700876
32RIPK11.21329584
33PTK21.20529432
34ICK1.19588923
35FGFR21.16994813
36LRRK21.16251202
37MTOR1.13818427
38NEK21.12937627
39FER1.11658003
40CDC71.11609103
41PRKD31.11037856
42ROCK11.08488581
43FLT31.01806082
44TTK0.98832467
45RPS6KA20.97282614
46TAF10.94960715
47ERBB40.93680267
48PNCK0.93482724
49CDK70.93259178
50RPS6KL10.92965706
51RPS6KC10.92965706
52ERN10.92753868
53ERBB20.88697801
54EPHA30.86956385
55BRSK10.86718442
56TGFBR10.85948267
57DYRK20.85413471
58CDK60.84524300
59MAP3K80.84110314
60NEK90.83979399
61PDGFRB0.83840904
62PAK30.80139923
63ROCK20.80044289
64SRPK10.78880506
65BRAF0.78713481
66NME20.78631787
67STK40.78036759
68ABL20.77765228
69MET0.77617765
70CDK80.74736872
71ERBB30.74487527
72CAMK1G0.74285887
73RPS6KB20.72589794
74RPS6KA60.72435579
75DYRK1B0.72176314
76EPHA40.70516101
77PAK60.70108677
78PRKD20.70055454
79AKT20.69455380
80DYRK30.66049026
81PAK10.65676478
82TESK20.64217859
83CDC42BPA0.62178125
84MAP3K60.61441538
85EPHB10.60662499
86TGFBR20.60588748
87AURKB0.60350508
88CAMK1D0.59719294
89WNK10.58275144
90MOS0.58139554
91PLK10.58062032
92LMTK20.55235253
93KSR10.54955663
94PLK30.53848738
95LIMK10.53243243
96TESK10.52845191
97STK380.51730721
98TAOK20.51069291
99DAPK30.49831698
100CLK10.49335830
101PLK40.48371968
102GRK70.48141367
103PRKG20.47760924
104MELK0.47173920
105ALK0.46985661
106BRSK20.46952866
107WEE10.46647261
108TYRO30.43802578
109NEK10.43333112
110ARAF0.42901664
111CHEK10.42480417
112PASK0.42191123
113CDK140.41384822
114BRD40.41140288
115MAPK70.40566350
116ADRBK10.40432670
117AKT10.39715508
118PRKD10.39700184
119PTK2B0.39103235
120PRKCI0.39036441
121CDK150.38859712
122CDK20.38772397
123CDK90.38177513
124TRPM70.37992779
125AURKA0.37037637
126CDK11A0.36945119
127CSNK1E0.36185155
128CDK10.34823025
129CDK180.34638582
130ATR0.34324259
131CDK40.33471185
132CHEK20.33249398
133MAPK10.33029797

Predicted pathways (KEGG)

RankGene SetZ-score
1* Basal cell carcinoma_Homo sapiens_hsa052173.96801929
2Hedgehog signaling pathway_Homo sapiens_hsa043403.45437365
3ECM-receptor interaction_Homo sapiens_hsa045122.98045785
4* Hippo signaling pathway_Homo sapiens_hsa043902.90104205
5TGF-beta signaling pathway_Homo sapiens_hsa043502.41447826
6* Proteoglycans in cancer_Homo sapiens_hsa052052.25517232
7Adherens junction_Homo sapiens_hsa045202.24474260
8Focal adhesion_Homo sapiens_hsa045102.23210322
9Bladder cancer_Homo sapiens_hsa052192.22021972
10* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.13594301
11MicroRNAs in cancer_Homo sapiens_hsa052062.10513109
12Ribosome_Homo sapiens_hsa030102.06227264
13Spliceosome_Homo sapiens_hsa030401.91348740
14* Wnt signaling pathway_Homo sapiens_hsa043101.90975338
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.88271436
16Cell cycle_Homo sapiens_hsa041101.81583673
17Notch signaling pathway_Homo sapiens_hsa043301.81290399
18Protein digestion and absorption_Homo sapiens_hsa049741.80728074
19Small cell lung cancer_Homo sapiens_hsa052221.70076550
20Axon guidance_Homo sapiens_hsa043601.68632491
21Melanoma_Homo sapiens_hsa052181.61673336
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60345192
23Chronic myeloid leukemia_Homo sapiens_hsa052201.58669498
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58133806
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.54577673
26Tight junction_Homo sapiens_hsa045301.54340058
27* Melanogenesis_Homo sapiens_hsa049161.51682987
28Dilated cardiomyopathy_Homo sapiens_hsa054141.49213637
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.43112236
30* Pathways in cancer_Homo sapiens_hsa052001.40299504
31Prostate cancer_Homo sapiens_hsa052151.34063974
32RNA transport_Homo sapiens_hsa030131.32872460
33* HTLV-I infection_Homo sapiens_hsa051661.32325574
34p53 signaling pathway_Homo sapiens_hsa041151.31480416
35Amoebiasis_Homo sapiens_hsa051461.31263834
36mRNA surveillance pathway_Homo sapiens_hsa030151.30267156
37PI3K-Akt signaling pathway_Homo sapiens_hsa041511.27400138
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24190157
39Glioma_Homo sapiens_hsa052141.19837190
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.16756050
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.16701347
42Endometrial cancer_Homo sapiens_hsa052131.15733398
43Colorectal cancer_Homo sapiens_hsa052101.15344529
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.14899088
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.09007986
46DNA replication_Homo sapiens_hsa030301.07777359
47Rap1 signaling pathway_Homo sapiens_hsa040151.06486913
48One carbon pool by folate_Homo sapiens_hsa006701.05568654
49Thyroid cancer_Homo sapiens_hsa052161.04421814
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99458144
51N-Glycan biosynthesis_Homo sapiens_hsa005100.96972874
52Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96220701
53Pentose phosphate pathway_Homo sapiens_hsa000300.88714404
54Viral myocarditis_Homo sapiens_hsa054160.88292218
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.88043468
56Biosynthesis of amino acids_Homo sapiens_hsa012300.87818623
57Prion diseases_Homo sapiens_hsa050200.87236079
58Lysine degradation_Homo sapiens_hsa003100.86014720
59Mismatch repair_Homo sapiens_hsa034300.85599456
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85534734
61Renal cell carcinoma_Homo sapiens_hsa052110.84931728
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84755533
63Gap junction_Homo sapiens_hsa045400.82719962
64Pyrimidine metabolism_Homo sapiens_hsa002400.82222476
65Vibrio cholerae infection_Homo sapiens_hsa051100.79320106
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79037195
67Oocyte meiosis_Homo sapiens_hsa041140.78058785
68Viral carcinogenesis_Homo sapiens_hsa052030.76738735
69Galactose metabolism_Homo sapiens_hsa000520.76533948
70Folate biosynthesis_Homo sapiens_hsa007900.75674331
71Pancreatic cancer_Homo sapiens_hsa052120.75505339
72Base excision repair_Homo sapiens_hsa034100.73374941
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.73191348
74Nucleotide excision repair_Homo sapiens_hsa034200.73035755
75Non-small cell lung cancer_Homo sapiens_hsa052230.71193769
76mTOR signaling pathway_Homo sapiens_hsa041500.66858332
77Estrogen signaling pathway_Homo sapiens_hsa049150.64593487
78Systemic lupus erythematosus_Homo sapiens_hsa053220.63464723
79Malaria_Homo sapiens_hsa051440.63422824
80HIF-1 signaling pathway_Homo sapiens_hsa040660.60856683
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.59546830
82RNA degradation_Homo sapiens_hsa030180.58430348
83Alcoholism_Homo sapiens_hsa050340.56098007
84FoxO signaling pathway_Homo sapiens_hsa040680.55809900
85Steroid biosynthesis_Homo sapiens_hsa001000.55738981
86Shigellosis_Homo sapiens_hsa051310.55551830
87Homologous recombination_Homo sapiens_hsa034400.54808372
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.53485101
89GnRH signaling pathway_Homo sapiens_hsa049120.50627480
90ErbB signaling pathway_Homo sapiens_hsa040120.50614442
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50111796
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49965174
93Protein export_Homo sapiens_hsa030600.48710535
94Cocaine addiction_Homo sapiens_hsa050300.48162902
95Ras signaling pathway_Homo sapiens_hsa040140.47951494
96Huntingtons disease_Homo sapiens_hsa050160.46218874
97Other glycan degradation_Homo sapiens_hsa005110.46169654
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46050702
99Glutathione metabolism_Homo sapiens_hsa004800.43473627
100Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43174756
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42648494
102Hepatitis B_Homo sapiens_hsa051610.42416680
103RNA polymerase_Homo sapiens_hsa030200.42155224
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.40380902
105Insulin signaling pathway_Homo sapiens_hsa049100.39938429
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39327976
107Fanconi anemia pathway_Homo sapiens_hsa034600.39220590
108Sulfur relay system_Homo sapiens_hsa041220.38950268
109AMPK signaling pathway_Homo sapiens_hsa041520.38912478
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38191614
111Salmonella infection_Homo sapiens_hsa051320.37985867
112Proteasome_Homo sapiens_hsa030500.37805671
113MAPK signaling pathway_Homo sapiens_hsa040100.37434859
114VEGF signaling pathway_Homo sapiens_hsa043700.37314153
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36319464
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34461440
117Vitamin B6 metabolism_Homo sapiens_hsa007500.34060573
118Thyroid hormone synthesis_Homo sapiens_hsa049180.33608198
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33165893
120Cardiac muscle contraction_Homo sapiens_hsa042600.32633696
121Epstein-Barr virus infection_Homo sapiens_hsa051690.32173637
122Endocytosis_Homo sapiens_hsa041440.31994492
123Dorso-ventral axis formation_Homo sapiens_hsa043200.31623137
124Platelet activation_Homo sapiens_hsa046110.31529109

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