FYB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.03256596
2negative regulation of cell killing (GO:0031342)5.31022143
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.31022143
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03104796
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.97791593
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.97791593
7modulation by symbiont of host immune response (GO:0052553)4.97791593
8positive regulation by symbiont of host defense response (GO:0052509)4.97791593
9modulation by symbiont of host defense response (GO:0052031)4.97791593
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.97791593
11regulation of B cell receptor signaling pathway (GO:0050855)4.62392406
12detection of molecule of bacterial origin (GO:0032490)4.39923648
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.39323618
14positive thymic T cell selection (GO:0045059)4.35978621
15regulation of gamma-delta T cell activation (GO:0046643)4.35663574
16regulation of gamma-delta T cell differentiation (GO:0045586)4.33126035
17negative T cell selection (GO:0043383)4.26090272
18negative regulation of lymphocyte mediated immunity (GO:0002707)4.24836768
19detection of other organism (GO:0098543)4.22804123
20negative regulation of T cell mediated immunity (GO:0002710)4.22690790
21regulation of interferon-beta biosynthetic process (GO:0045357)4.14173880
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12775103
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.12775103
24leukocyte aggregation (GO:0070486)4.12742559
25negative thymic T cell selection (GO:0045060)4.09822219
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.00791316
27tolerance induction (GO:0002507)3.98460166
28detection of external biotic stimulus (GO:0098581)3.97960771
29neutrophil activation involved in immune response (GO:0002283)3.93568774
30T cell migration (GO:0072678)3.91161527
31detection of bacterium (GO:0016045)3.87486150
32interferon-gamma production (GO:0032609)3.86223849
33immunoglobulin mediated immune response (GO:0016064)3.84554469
34positive T cell selection (GO:0043368)3.83990965
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.77733071
36response to muramyl dipeptide (GO:0032495)3.77359054
37positive regulation of B cell differentiation (GO:0045579)3.75181654
38regulation of regulatory T cell differentiation (GO:0045589)3.74069700
39antigen processing and presentation of endogenous antigen (GO:0019883)3.73518821
40positive regulation of interferon-alpha production (GO:0032727)3.72162526
41response to peptidoglycan (GO:0032494)3.70830290
42negative regulation of leukocyte mediated immunity (GO:0002704)3.68392227
43macrophage activation involved in immune response (GO:0002281)3.61368201
44regulation of interferon-alpha production (GO:0032647)3.61357962
45positive regulation of granulocyte differentiation (GO:0030854)3.61336699
46positive regulation of antigen processing and presentation (GO:0002579)3.54488294
47response to type I interferon (GO:0034340)3.53397760
48macrophage activation (GO:0042116)3.52021433
49detection of biotic stimulus (GO:0009595)3.48644521
50type I interferon signaling pathway (GO:0060337)3.48583550
51cellular response to type I interferon (GO:0071357)3.48583550
52T cell selection (GO:0045058)3.47013867
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.46674469
54thymic T cell selection (GO:0045061)3.46670260
55negative regulation of interleukin-12 production (GO:0032695)3.46210111
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.45016434
57NIK/NF-kappaB signaling (GO:0038061)3.44269370
58cellular extravasation (GO:0045123)3.44079735
59regulation of T cell tolerance induction (GO:0002664)3.40662297
60neutrophil mediated immunity (GO:0002446)3.40011050
61myeloid cell activation involved in immune response (GO:0002275)3.38404555
62regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.34639304
63germinal center formation (GO:0002467)3.34489265
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.31915603
65respiratory burst (GO:0045730)3.30727682
66regulation of natural killer cell mediated immunity (GO:0002715)3.29031823
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.29031823
68response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.28318999
69response to host immune response (GO:0052572)3.28318999
70regulation of B cell differentiation (GO:0045577)3.26639697
71mast cell activation (GO:0045576)3.26617066
72regulation of T cell mediated cytotoxicity (GO:0001914)3.23849380
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.21846993
74dendritic cell migration (GO:0036336)3.21756564
75interferon-gamma-mediated signaling pathway (GO:0060333)3.21541381
76negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.19231357
77myeloid leukocyte mediated immunity (GO:0002444)3.18355917
78modulation by symbiont of host cellular process (GO:0044068)3.17576004
79regulation of alpha-beta T cell proliferation (GO:0046640)3.16738584
80neutrophil activation (GO:0042119)3.16243879
81microglial cell activation (GO:0001774)3.16018055
82leukocyte migration involved in inflammatory response (GO:0002523)3.14014110
83negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.13612525
84positive regulation of mast cell activation (GO:0033005)3.13528996
85dendritic cell chemotaxis (GO:0002407)3.13139091
86positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.13038719
87B cell receptor signaling pathway (GO:0050853)3.11922676
88activated T cell proliferation (GO:0050798)3.11508984
89regulation of antigen processing and presentation (GO:0002577)3.10369326
90production of molecular mediator involved in inflammatory response (GO:0002532)3.10055954
91response to host (GO:0075136)3.09330479
92response to host defenses (GO:0052200)3.09330479
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.09330479
94leukocyte cell-cell adhesion (GO:0007159)3.09247894
95pinocytosis (GO:0006907)3.08130422
96negative regulation of granulocyte differentiation (GO:0030853)3.07658153
97B cell mediated immunity (GO:0019724)3.06073603
98positive regulation of T cell mediated cytotoxicity (GO:0001916)3.06071904
99myeloid dendritic cell activation (GO:0001773)3.05545064
100granulocyte activation (GO:0036230)3.05509696
101leukocyte degranulation (GO:0043299)3.00168955
102negative regulation of adaptive immune response (GO:0002820)2.98815967
103mature B cell differentiation (GO:0002335)2.97130987
104negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.96888370
105regulation of leukocyte mediated cytotoxicity (GO:0001910)2.96499025
106regulation of isotype switching to IgG isotypes (GO:0048302)2.92841022
107regulation of mast cell degranulation (GO:0043304)2.91921977
108response to interleukin-15 (GO:0070672)2.91774595
109defense response to protozoan (GO:0042832)2.91242640
110positive regulation of isotype switching (GO:0045830)2.90822633
111natural killer cell mediated cytotoxicity (GO:0042267)2.90019117
112natural killer cell mediated immunity (GO:0002228)2.90019117
113* antigen receptor-mediated signaling pathway (GO:0050851)2.88779839
114regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88719814
115positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87425773
116hepatocyte apoptotic process (GO:0097284)2.87058721
117negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.86241279
118negative regulation of T-helper cell differentiation (GO:0045623)2.86241279
119regulation of interleukin-2 biosynthetic process (GO:0045076)2.86093119
120B cell homeostasis (GO:0001782)2.85327708
121cellular response to interferon-beta (GO:0035458)2.83251429
122positive regulation of interferon-beta production (GO:0032728)2.82623494
123regulation of T cell receptor signaling pathway (GO:0050856)2.82145806
124positive regulation of tolerance induction (GO:0002645)2.81575630
125response to protozoan (GO:0001562)2.81473994
126* T cell receptor signaling pathway (GO:0050852)2.80969615
127regulation of tolerance induction (GO:0002643)2.80725446
128positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.79357393
129antigen processing and presentation via MHC class Ib (GO:0002475)2.78302401
130modulation by virus of host process (GO:0019054)2.78208453
131positive regulation of B cell mediated immunity (GO:0002714)2.76431049
132positive regulation of immunoglobulin mediated immune response (GO:0002891)2.76431049
133adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.72124388
134cellular response to interleukin-15 (GO:0071350)2.71182483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.27933802
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.98578335
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.93917157
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.43611220
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.33393964
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.74455442
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.64269150
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63678073
9* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63209399
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44361494
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.30613282
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13177911
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.99170259
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92126498
15SCL_19346495_ChIP-Seq_HPC-7_Human2.84094966
16E2F7_22180533_ChIP-Seq_HELA_Human2.82170700
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80896424
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73217817
19* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59004595
20RUNX_20019798_ChIP-Seq_JUKART_Human2.56700478
21* MYB_26560356_Chip-Seq_TH2_Human2.45334170
22VDR_21846776_ChIP-Seq_THP-1_Human2.45093772
23* SPI1_23547873_ChIP-Seq_NB4_Human2.43806009
24MAF_26560356_Chip-Seq_TH1_Human2.31876020
25* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.28325180
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26963871
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.24266697
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23993264
29MYB_26560356_Chip-Seq_TH1_Human2.18269078
30MYC_22102868_ChIP-Seq_BL_Human2.16247645
31VDR_24763502_ChIP-Seq_THP-1_Human2.16243488
32* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12113809
33RUNX1_22412390_ChIP-Seq_EML_Mouse2.11329551
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.01942627
35UTX_26944678_Chip-Seq_JUKART_Human2.01555215
36SPI1_23127762_ChIP-Seq_K562_Human1.99664845
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92937359
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82703505
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.81601697
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81461170
41PU_27001747_Chip-Seq_BMDM_Mouse1.76108434
42TCF7_22412390_ChIP-Seq_EML_Mouse1.73823174
43* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72029877
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.69832462
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.66793584
46E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65014173
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63694564
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.59242985
49MAF_26560356_Chip-Seq_TH2_Human1.57417278
50GATA3_27048872_Chip-Seq_THYMUS_Human1.57272210
51* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.52305915
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50550868
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45198017
54FOXM1_23109430_ChIP-Seq_U2OS_Human1.41026554
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36255583
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35000114
57* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34961701
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34079880
59VDR_24787735_ChIP-Seq_THP-1_Human1.31577124
60* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27862464
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27593025
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22743027
63GATA3_26560356_Chip-Seq_TH2_Human1.20371216
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18962929
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17308408
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16459643
67KDM2B_26808549_Chip-Seq_DND41_Human1.16095413
68* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14713883
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14576986
70* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13214565
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.11692478
72* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11158674
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08752944
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08203311
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07332944
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.06064654
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05554061
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.04693723
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.03100126
80GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02768461
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00734899
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96869255
83STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93420994
84GATA2_21666600_ChIP-Seq_HMVEC_Human0.93386068
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93071705
86HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91888514
87KDM2B_26808549_Chip-Seq_JURKAT_Human0.91568530
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91306971
89GATA1_22025678_ChIP-Seq_K562_Human0.91257382
90SMRT_27268052_Chip-Seq_Bcells_Human0.90518487
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86455174
92CIITA_25753668_ChIP-Seq_RAJI_Human0.85893296
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85462392
94RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82566361
95E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82287644
96TFEB_21752829_ChIP-Seq_HELA_Human0.82278762
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.78114981
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77735706
99* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75464879
100SPI1_20517297_ChIP-Seq_HL60_Human0.74399080
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73292997
102NCOR1_26117541_ChIP-Seq_K562_Human0.70913286
103GATA2_19941826_ChIP-Seq_K562_Human0.70829446
104GATA3_26560356_Chip-Seq_TH1_Human0.70532691
105SMAD_19615063_ChIP-ChIP_OVARY_Human0.70012341
106KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.67106276
107IKZF1_21737484_ChIP-ChIP_HCT116_Human0.66875400
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65807998
109GATA1_19941826_ChIP-Seq_K562_Human0.65586968
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65482359
111* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.65266382
112ETS1_22383799_ChIP-Seq_G1ME_Mouse0.64799680
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64299280
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64278541

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.98002880
2MP0005671_abnormal_response_to3.39983650
3MP0003436_decreased_susceptibility_to3.11147272
4MP0000685_abnormal_immune_system3.00576995
5MP0005000_abnormal_immune_tolerance2.90750003
6MP0001800_abnormal_humoral_immune2.90509090
7MP0003763_abnormal_thymus_physiology2.84255909
8MP0009785_altered_susceptibility_to2.80078819
9MP0005387_immune_system_phenotype2.79771242
10MP0001790_abnormal_immune_system2.79771242
11MP0002419_abnormal_innate_immunity2.74795994
12MP0000569_abnormal_digit_pigmentation2.74780449
13MP0006082_CNS_inflammation2.71743140
14MP0005025_abnormal_response_to2.70947766
15MP0002452_abnormal_antigen_presenting2.69243755
16MP0003303_peritoneal_inflammation2.65322949
17* MP0002723_abnormal_immune_serum2.63008038
18MP0002148_abnormal_hypersensitivity_rea2.62779679
19* MP0001819_abnormal_immune_cell2.48973376
20* MP0002420_abnormal_adaptive_immunity2.48726002
21MP0005058_abnormal_lysosome_morphology2.45197433
22MP0003724_increased_susceptibility_to2.42254207
23MP0005464_abnormal_platelet_physiology2.39880752
24MP0002396_abnormal_hematopoietic_system2.27885473
25MP0002405_respiratory_system_inflammati2.23477528
26MP0004510_myositis2.22001935
27MP0002166_altered_tumor_susceptibility2.19582206
28* MP0002398_abnormal_bone_marrow2.16713701
29MP0009278_abnormal_bone_marrow2.11600853
30MP0009333_abnormal_splenocyte_physiolog2.10620304
31MP0005174_abnormal_tail_pigmentation2.09804810
32MP0003300_gastrointestinal_ulcer2.08386151
33MP0004947_skin_inflammation2.07235986
34* MP0000716_abnormal_immune_system2.01224303
35MP0003172_abnormal_lysosome_physiology1.97328881
36MP0001873_stomach_inflammation1.90798442
37MP0010155_abnormal_intestine_physiology1.90689440
38MP0000689_abnormal_spleen_morphology1.88684734
39MP0001853_heart_inflammation1.87117531
40MP0002006_tumorigenesis1.87116877
41MP0002722_abnormal_immune_system1.82050015
42MP0001845_abnormal_inflammatory_respons1.76792581
43MP0001545_abnormal_hematopoietic_system1.72928016
44MP0005397_hematopoietic_system_phenotyp1.72928016
45* MP0000703_abnormal_thymus_morphology1.67241074
46MP0001533_abnormal_skeleton_physiology1.66231235
47* MP0002429_abnormal_blood_cell1.65684652
48MP0004808_abnormal_hematopoietic_stem1.60295477
49MP0005451_abnormal_body_composition1.51651645
50MP0004883_abnormal_blood_vessel1.51281986
51MP0000015_abnormal_ear_pigmentation1.50552056
52MP0003448_altered_tumor_morphology1.49581159
53MP0000465_gastrointestinal_hemorrhage1.46916205
54MP0008469_abnormal_protein_level1.45158421
55MP0000858_altered_metastatic_potential1.44725084
56MP0002933_joint_inflammation1.38840451
57MP0005310_abnormal_salivary_gland1.38555053
58MP0003866_abnormal_defecation1.31292847
59MP0002998_abnormal_bone_remodeling1.25107512
60MP0000490_abnormal_crypts_of1.21394599
61MP0001851_eye_inflammation1.16807465
62MP0005075_abnormal_melanosome_morpholog1.13176337
63MP0002277_abnormal_respiratory_mucosa1.10137342
64MP0003183_abnormal_peptide_metabolism1.08944323
65MP0009764_decreased_sensitivity_to1.08076964
66MP0003191_abnormal_cellular_cholesterol1.05881935
67MP0000343_altered_response_to1.05662203
68MP0005164_abnormal_response_to1.05174986
69MP0003690_abnormal_glial_cell1.02773765
70MP0004130_abnormal_muscle_cell1.01861187
71MP0002009_preneoplasia0.97566957
72MP0008004_abnormal_stomach_pH0.97565394
73MP0010307_abnormal_tumor_latency0.96658568
74MP0005076_abnormal_cell_differentiation0.96473709
75MP0004381_abnormal_hair_follicle0.95578948
76MP0009840_abnormal_foam_cell0.91227430
77MP0003787_abnormal_imprinting0.89653636
78MP0003828_pulmonary_edema0.89010363
79MP0009763_increased_sensitivity_to0.87754826
80MP0000371_diluted_coat_color0.87198525
81MP0003075_altered_response_to0.83248091
82MP0000604_amyloidosis0.77153262
83MP0005166_decreased_susceptibility_to0.76971579
84MP0005023_abnormal_wound_healing0.76598718
85MP0002019_abnormal_tumor_incidence0.75993783
86MP0005390_skeleton_phenotype0.75146105
87MP0002095_abnormal_skin_pigmentation0.74549164
88MP0004484_altered_response_of0.72532541
89MP0010352_gastrointestinal_tract_polyps0.71677897
90MP0002138_abnormal_hepatobiliary_system0.70402304
91MP0002132_abnormal_respiratory_system0.68934354
92MP0003045_fibrosis0.67847167
93MP0000249_abnormal_blood_vessel0.67805978
94MP0003453_abnormal_keratinocyte_physiol0.67285041
95MP0003795_abnormal_bone_structure0.67184833
96MP0001663_abnormal_digestive_system0.63032463
97MP0003656_abnormal_erythrocyte_physiolo0.61514066
98MP0003221_abnormal_cardiomyocyte_apopto0.61343370
99MP0008874_decreased_physiological_sensi0.60994800
100MP0003693_abnormal_embryo_hatching0.59822963
101MP0003566_abnormal_cell_adhesion0.58879258
102MP0008007_abnormal_cellular_replicative0.58459636
103MP0003091_abnormal_cell_migration0.56901451
104MP0009765_abnormal_xenobiotic_induced0.55800125
105MP0002332_abnormal_exercise_endurance0.54306076
106MP0003077_abnormal_cell_cycle0.53163383
107MP0000313_abnormal_cell_death0.53160856
108MP0002136_abnormal_kidney_physiology0.52428689
109MP0001986_abnormal_taste_sensitivity0.51872243
110MP0008057_abnormal_DNA_replication0.51158300
111MP0008260_abnormal_autophagy0.50690768
112MP0000609_abnormal_liver_physiology0.50333270
113MP0006054_spinal_hemorrhage0.47493202
114MP0005376_homeostasis/metabolism_phenot0.46452108
115MP0002693_abnormal_pancreas_physiology0.46269885
116MP0002133_abnormal_respiratory_system0.46167551
117MP0001191_abnormal_skin_condition0.45868116
118MP0001243_abnormal_dermal_layer0.45866562

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.16067140
2Eczematoid dermatitis (HP:0000976)5.58723847
3Recurrent bacterial skin infections (HP:0005406)5.54167408
4Elevated erythrocyte sedimentation rate (HP:0003565)5.04092173
5Stomatitis (HP:0010280)4.62712429
6Recurrent fungal infections (HP:0002841)4.62178834
7Recurrent viral infections (HP:0004429)4.30283863
8Myositis (HP:0100614)4.28940625
9T lymphocytopenia (HP:0005403)4.09710263
10Abnormality of T cell number (HP:0011839)3.95837089
11Pustule (HP:0200039)3.95037926
12Mediastinal lymphadenopathy (HP:0100721)3.91104431
13Recurrent skin infections (HP:0001581)3.89180886
14Recurrent gram-negative bacterial infections (HP:0005420)3.89144382
15Abnormality of macrophages (HP:0004311)3.76563657
16Autoimmune thrombocytopenia (HP:0001973)3.61247392
17Chronic mucocutaneous candidiasis (HP:0002728)3.59400889
18Recurrent cutaneous fungal infections (HP:0011370)3.59400889
19Retrobulbar optic neuritis (HP:0100654)3.55788398
20Optic neuritis (HP:0100653)3.55788398
21Obstructive lung disease (HP:0006536)3.54945926
22Chronic obstructive pulmonary disease (HP:0006510)3.54945926
23Orchitis (HP:0100796)3.54423270
24Systemic lupus erythematosus (HP:0002725)3.53157639
25Leukocytosis (HP:0001974)3.46970391
26Severe combined immunodeficiency (HP:0004430)3.45033212
27Gingivitis (HP:0000230)3.44682610
28Eosinophilia (HP:0001880)3.43682975
29Chest pain (HP:0100749)3.29765752
30Vacuolated lymphocytes (HP:0001922)3.22961204
31Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.21590099
32Panhypogammaglobulinemia (HP:0003139)3.19285148
33Combined immunodeficiency (HP:0005387)3.14171512
34Abnormality of T cells (HP:0002843)3.13823471
35Periodontitis (HP:0000704)3.13086771
36Thyroiditis (HP:0100646)3.10153954
37Granulocytopenia (HP:0001913)3.09638976
38Abnormality of eosinophils (HP:0001879)3.08250345
39Vasculitis (HP:0002633)3.03330299
40Meningitis (HP:0001287)3.00239683
41IgM deficiency (HP:0002850)2.98858137
42Chronic otitis media (HP:0000389)2.96283742
43Abnormality of the fingertips (HP:0001211)2.95350644
44Prostate neoplasm (HP:0100787)2.90309437
45Inflammation of the large intestine (HP:0002037)2.83609708
46Increased cerebral lipofuscin (HP:0011813)2.83150586
47Spontaneous hematomas (HP:0007420)2.79276211
48Pulmonary embolism (HP:0002204)2.78345582
49Prolonged bleeding time (HP:0003010)2.77365499
50Nasal polyposis (HP:0100582)2.70557631
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.70310310
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.70061577
53Peritonitis (HP:0002586)2.67009735
54Anorexia (HP:0002039)2.65509459
55Gastrointestinal inflammation (HP:0004386)2.65313569
56Gingival bleeding (HP:0000225)2.62709441
57Abnormal platelet volume (HP:0011876)2.61985157
58Glomerulonephritis (HP:0000099)2.60232554
59Pulmonary infiltrates (HP:0002113)2.51742409
60Hemoptysis (HP:0002105)2.49992153
61B lymphocytopenia (HP:0010976)2.49524502
62Abnormality of B cell number (HP:0010975)2.49524502
63Recurrent bronchitis (HP:0002837)2.49319886
64Hypochromic microcytic anemia (HP:0004840)2.49313095
65Chronic diarrhea (HP:0002028)2.48206841
66Epistaxis (HP:0000421)2.47849998
67Petechiae (HP:0000967)2.47420047
68Gangrene (HP:0100758)2.46553673
69Cellulitis (HP:0100658)2.43455640
70Abnormality of the prostate (HP:0008775)2.43443613
71Colitis (HP:0002583)2.40932279
72Hypochromic anemia (HP:0001931)2.40292689
73Purpura (HP:0000979)2.39385313
74Increased IgE level (HP:0003212)2.38691255
75Episodic fever (HP:0001954)2.38191745
76Arterial thrombosis (HP:0004420)2.35203602
77Slow saccadic eye movements (HP:0000514)2.33743744
78Abnormality of the nasal mucosa (HP:0000433)2.33501780
79Disinhibition (HP:0000734)2.33015400
80Cheilitis (HP:0100825)2.32705096
81Abnormality of T cell physiology (HP:0011840)2.31641261
82IgG deficiency (HP:0004315)2.30508151
83Hematochezia (HP:0002573)2.29858112
84Abnormality of liposaccharide metabolism (HP:0010968)2.27177624
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.27177624
86Abnormality of glycolipid metabolism (HP:0010969)2.27177624
87Autoimmune hemolytic anemia (HP:0001890)2.26351926
88Encephalitis (HP:0002383)2.25799687
89Microcytic anemia (HP:0001935)2.25740028
90Impaired platelet aggregation (HP:0003540)2.25335958
91Abnormal platelet function (HP:0011869)2.25335958
92Urticaria (HP:0001025)2.22939567
93Acute hepatic failure (HP:0006554)2.22889663
94Thick nail (HP:0001805)2.22524221
95Dysostosis multiplex (HP:0000943)2.21927910
96Lymphopenia (HP:0001888)2.21278841
97Basal ganglia calcification (HP:0002135)2.20071440
98Keratoconjunctivitis sicca (HP:0001097)2.19541349
99Abnormality of the pleura (HP:0002103)2.18307026
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.16292869
101Hypoplasia of the thymus (HP:0000778)2.13202641
102Thrombocytosis (HP:0001894)2.12996983
103Agnosia (HP:0010524)2.12558708
104Glomerulopathy (HP:0100820)2.11242985
105Osteomyelitis (HP:0002754)2.11218150
106Menorrhagia (HP:0000132)2.11160881
107Vertigo (HP:0002321)2.09107020
108Sepsis (HP:0100806)2.07909998
109Increased mean platelet volume (HP:0011877)2.06673685
110Abnormality of the endocardium (HP:0004306)2.05397474
111Abnormality of the peritoneum (HP:0002585)2.02840889
112Papilledema (HP:0001085)2.00087093
113Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.00077070
114Papilloma (HP:0012740)1.98863260
115Verrucae (HP:0200043)1.98863260
116Keratoconjunctivitis (HP:0001096)1.98413439
117Hepatosplenomegaly (HP:0001433)1.97718323
118Keratitis (HP:0000491)1.97106844
119Recurrent pneumonia (HP:0006532)1.96808025
120Amaurosis fugax (HP:0100576)1.96154052
121Increased IgM level (HP:0003496)1.95420906
122Agammaglobulinemia (HP:0004432)1.94307164
123Viral hepatitis (HP:0006562)1.94153179
124Amyloidosis (HP:0011034)1.93715825
125Hypergammaglobulinemia (HP:0010702)1.92989679
126Lymphoma (HP:0002665)1.92849112
127Joint swelling (HP:0001386)1.92320331
128Skin ulcer (HP:0200042)1.92314141
129Myocardial infarction (HP:0001658)1.91309967
130Urethral obstruction (HP:0000796)1.89758817
131Gastrointestinal infarctions (HP:0005244)1.89531965
132Stomach cancer (HP:0012126)1.88065531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.46910948
2MAP4K14.38669065
3TYK23.42175129
4IKBKE3.04117443
5MAP3K142.97262986
6IRAK42.76166405
7JAK32.64465884
8BLK2.59854871
9KIT2.57320389
10IRAK32.57123366
11ZAP702.54042209
12TBK12.51150417
13RIPK42.27649429
14JAK12.10541122
15ITK1.96196785
16TGFBR21.94795260
17STK101.92090080
18IKBKB1.84305626
19TAOK31.83466112
20FGFR41.82301702
21PRPF4B1.74895547
22TEC1.73614205
23HCK1.72848373
24* LCK1.61181972
25MAP3K131.60336969
26CSK1.59402141
27CSF1R1.56725442
28SYK1.56054840
29NME21.50775565
30FES1.49806723
31BTK1.45265964
32FGFR31.39916661
33CHUK1.29300234
34BMPR21.27015227
35PIK3CG1.25547442
36SIK21.25259389
37CAMKK21.25036080
38RPS6KA41.21171087
39CDK121.20483017
40CLK11.18535191
41PIM11.16605275
42MAP3K31.12558305
43MAP3K11.06627918
44JAK21.06542382
45MARK31.04037448
46* LYN1.02328707
47KSR20.99063951
48MAP3K20.96491020
49PIM20.95869511
50TAOK10.95518122
51NEK90.90548406
52MAP3K100.89375529
53STK40.87171097
54MAP3K110.86960812
55NLK0.85620421
56PTK2B0.85052873
57EPHB10.84543529
58TLK10.83702147
59GRK60.82851838
60MAP2K30.82793521
61CAMK1D0.80586396
62ERN10.79156821
63MARK20.77531103
64CDK60.77160297
65CAMKK10.75460107
66GRK70.72686523
67PRKCQ0.68301653
68YES10.67466442
69WNK10.64126209
70SGK30.62619816
71RAF10.62006491
72CAMK1G0.61061614
73SGK20.58109215
74PDPK10.54759192
75IRAK10.54350997
76EIF2AK20.53686093
77CDK40.53351107
78MAP3K60.52387249
79MAP3K50.51938623
80EEF2K0.49581564
81NUAK10.49008026
82CDC42BPA0.48612696
83NEK20.48584781
84FGR0.47795132
85GRK50.47140198
86RET0.46408977
87HIPK20.45644086
88PTK60.45476578
89RPS6KA50.45045161
90CDK90.43799105
91KDR0.43582880
92ACVR1B0.43049923
93KSR10.42510617
94TNK20.42402606
95PDGFRB0.42142171
96MAP2K60.42061047
97RPS6KA60.41936098
98ATR0.41726193
99MAPKAPK20.41472234
100FLT30.41390349
101PRKD20.41026179
102STK110.40937872
103TTN0.40507324
104TAOK20.40146347
105TRPM70.40049694
106LRRK20.40041292
107EPHA30.39821943
108STK380.39576886
109BRD40.39487816
110ABL10.39056603
111MAPK110.38993226
112MAPK70.38751281
113SIK30.38077095
114* EGFR0.37948686
115PDK10.36381756
116PKN20.36181764
117DYRK1B0.35162349
118PRKCD0.35045994
119PBK0.34770310
120IRAK20.33913858
121FRK0.33251730
122MAPK40.32867946
123MST40.32622627
124TESK20.32561258
125RPS6KC10.32212280
126RPS6KL10.32212280
127MAPK120.31717071
128DMPK0.29884923
129MATK0.29300094
130* FYN0.28142263
131MAP3K70.27327994
132PRKCH0.27194539

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.03379577
2Leishmaniasis_Homo sapiens_hsa051402.89190002
3Staphylococcus aureus infection_Homo sapiens_hsa051502.81508146
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.66430557
5Osteoclast differentiation_Homo sapiens_hsa043802.61628962
6Measles_Homo sapiens_hsa051622.58486771
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.46403572
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.24243919
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.21559743
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.20208360
11T cell receptor signaling pathway_Homo sapiens_hsa046602.20079140
12Graft-versus-host disease_Homo sapiens_hsa053322.15804473
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.10266153
14B cell receptor signaling pathway_Homo sapiens_hsa046622.08414422
15Allograft rejection_Homo sapiens_hsa053302.07256629
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04890745
17Hematopoietic cell lineage_Homo sapiens_hsa046402.03466066
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95993812
19Antigen processing and presentation_Homo sapiens_hsa046121.95053366
20Pertussis_Homo sapiens_hsa051331.76357680
21Herpes simplex infection_Homo sapiens_hsa051681.75442156
22Influenza A_Homo sapiens_hsa051641.72885145
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.66530295
24Other glycan degradation_Homo sapiens_hsa005111.65730876
25Asthma_Homo sapiens_hsa053101.63425882
26Tuberculosis_Homo sapiens_hsa051521.61874744
27Malaria_Homo sapiens_hsa051441.61047463
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.60893063
29Legionellosis_Homo sapiens_hsa051341.55198161
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54298824
31Toxoplasmosis_Homo sapiens_hsa051451.54198754
32TNF signaling pathway_Homo sapiens_hsa046681.44765782
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.44007013
34Chemokine signaling pathway_Homo sapiens_hsa040621.40099419
35Hepatitis B_Homo sapiens_hsa051611.38241560
36Apoptosis_Homo sapiens_hsa042101.38216165
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.38015202
38Acute myeloid leukemia_Homo sapiens_hsa052211.27521969
39Shigellosis_Homo sapiens_hsa051311.25700314
40Lysosome_Homo sapiens_hsa041421.23803571
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20922536
42Leukocyte transendothelial migration_Homo sapiens_hsa046701.18004635
43Viral myocarditis_Homo sapiens_hsa054161.15197055
44Chronic myeloid leukemia_Homo sapiens_hsa052201.13513510
45Autoimmune thyroid disease_Homo sapiens_hsa053201.11264866
46Hepatitis C_Homo sapiens_hsa051601.10103419
47Salmonella infection_Homo sapiens_hsa051321.07104549
48Rheumatoid arthritis_Homo sapiens_hsa053231.04991894
49Platelet activation_Homo sapiens_hsa046110.96786770
50Pancreatic cancer_Homo sapiens_hsa052120.95304322
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89417371
52Non-homologous end-joining_Homo sapiens_hsa034500.87236004
53Caffeine metabolism_Homo sapiens_hsa002320.87080364
54Epstein-Barr virus infection_Homo sapiens_hsa051690.86735198
55Renal cell carcinoma_Homo sapiens_hsa052110.80972917
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80744438
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80666734
58Dorso-ventral axis formation_Homo sapiens_hsa043200.79021340
59African trypanosomiasis_Homo sapiens_hsa051430.75436844
60Ribosome_Homo sapiens_hsa030100.74644540
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74627233
62HTLV-I infection_Homo sapiens_hsa051660.73704090
63Phagosome_Homo sapiens_hsa041450.72180121
64Endometrial cancer_Homo sapiens_hsa052130.69703603
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69002574
66Prolactin signaling pathway_Homo sapiens_hsa049170.67479013
67Viral carcinogenesis_Homo sapiens_hsa052030.66574761
68Notch signaling pathway_Homo sapiens_hsa043300.66428736
69Type I diabetes mellitus_Homo sapiens_hsa049400.65324959
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.64407497
71Small cell lung cancer_Homo sapiens_hsa052220.64193759
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62099680
73Choline metabolism in cancer_Homo sapiens_hsa052310.60366900
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.59928695
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.59409385
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57240432
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54798535
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51987295
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51426300
80Regulation of autophagy_Homo sapiens_hsa041400.50830044
81GnRH signaling pathway_Homo sapiens_hsa049120.50318271
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48992930
83Homologous recombination_Homo sapiens_hsa034400.48919722
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48780619
85p53 signaling pathway_Homo sapiens_hsa041150.47758754
86mTOR signaling pathway_Homo sapiens_hsa041500.47528024
87MAPK signaling pathway_Homo sapiens_hsa040100.45867145
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.45386331
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45192139
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44663111
91Long-term potentiation_Homo sapiens_hsa047200.44606855
92Colorectal cancer_Homo sapiens_hsa052100.44073648
93Non-small cell lung cancer_Homo sapiens_hsa052230.43855617
94ErbB signaling pathway_Homo sapiens_hsa040120.43399341
95VEGF signaling pathway_Homo sapiens_hsa043700.41971258
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39917225
97Base excision repair_Homo sapiens_hsa034100.39411765
98HIF-1 signaling pathway_Homo sapiens_hsa040660.39372700
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38960252
100Glioma_Homo sapiens_hsa052140.38896278
101DNA replication_Homo sapiens_hsa030300.38281892
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37759867
103Amoebiasis_Homo sapiens_hsa051460.37725640
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37722635
105Ras signaling pathway_Homo sapiens_hsa040140.37098288
106Endocytosis_Homo sapiens_hsa041440.36847702
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.35004314
108Fanconi anemia pathway_Homo sapiens_hsa034600.34986973
109FoxO signaling pathway_Homo sapiens_hsa040680.34686663
110MicroRNAs in cancer_Homo sapiens_hsa052060.33642428
111Complement and coagulation cascades_Homo sapiens_hsa046100.32250841
112ABC transporters_Homo sapiens_hsa020100.31577851
113Lysine degradation_Homo sapiens_hsa003100.31468727
114Prostate cancer_Homo sapiens_hsa052150.30258757
115Insulin resistance_Homo sapiens_hsa049310.27592271
116Type II diabetes mellitus_Homo sapiens_hsa049300.25323341
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24893961
118Inositol phosphate metabolism_Homo sapiens_hsa005620.24666986
119Spliceosome_Homo sapiens_hsa030400.23851799
120Systemic lupus erythematosus_Homo sapiens_hsa053220.23254794
121One carbon pool by folate_Homo sapiens_hsa006700.22976290

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