FXYD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)7.82764518
2aminoglycoside antibiotic metabolic process (GO:0030647)7.69558069
3urate metabolic process (GO:0046415)7.55294617
4regulation of type B pancreatic cell apoptotic process (GO:2000674)6.60161091
5drug transport (GO:0015893)6.55529096
6organic cation transport (GO:0015695)6.51711438
7lysine metabolic process (GO:0006553)6.39123367
8lysine catabolic process (GO:0006554)6.39123367
9positive regulation of glycolytic process (GO:0045821)6.02343926
10response to mercury ion (GO:0046689)5.98610028
11phosphate ion transport (GO:0006817)5.90091485
12endocrine pancreas development (GO:0031018)5.69072061
13excretion (GO:0007588)5.60215871
14peripheral nervous system neuron development (GO:0048935)5.49093176
15quaternary ammonium group transport (GO:0015697)5.36284752
16negative regulation of gluconeogenesis (GO:0045721)5.22378589
17regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022355.19542188
18negative regulation of protein oligomerization (GO:0032460)5.14256372
19nonribosomal peptide biosynthetic process (GO:0019184)4.99244697
20glyoxylate metabolic process (GO:0046487)4.97292831
21fatty acid homeostasis (GO:0055089)4.91491560
22renal absorption (GO:0070293)4.90137557
23positive regulation of respiratory burst (GO:0060267)4.83663828
24regulation of glucokinase activity (GO:0033131)4.80997094
25regulation of hexokinase activity (GO:1903299)4.80997094
26phosphate ion transmembrane transport (GO:0035435)4.78230633
27exogenous drug catabolic process (GO:0042738)4.72921370
28tricarboxylic acid metabolic process (GO:0072350)4.71510415
29response to water (GO:0009415)4.68284185
30drug catabolic process (GO:0042737)4.65329629
31cysteine metabolic process (GO:0006534)4.64499446
32negative regulation of acute inflammatory response (GO:0002674)4.64371670
33glutathione biosynthetic process (GO:0006750)4.57866169
34insulin secretion (GO:0030073)4.53555316
35lactate metabolic process (GO:0006089)4.52213765
36negative regulation of dendrite morphogenesis (GO:0050774)4.46331172
37detection of temperature stimulus involved in sensory perception (GO:0050961)4.44197286
38detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.44197286
39metanephric tubule development (GO:0072170)4.41890264
40metanephric nephron tubule development (GO:0072234)4.41890264
41glycoside metabolic process (GO:0016137)4.40354079
42positive regulation of insulin secretion (GO:0032024)4.38663142
43positive regulation of peptide hormone secretion (GO:0090277)4.35488454
44aspartate family amino acid catabolic process (GO:0009068)4.35162918
45nitric oxide mediated signal transduction (GO:0007263)4.34298988
46epithelial cell fate commitment (GO:0072148)4.19794099
47positive regulation of peptide secretion (GO:0002793)4.18637230
48ketone body metabolic process (GO:1902224)4.17067036
49negative regulation of hormone biosynthetic process (GO:0032353)4.12458834
50polyol transport (GO:0015791)4.05177745
51amino-acid betaine transport (GO:0015838)4.04498227
52carnitine transport (GO:0015879)4.04498227
53metanephric nephron epithelium development (GO:0072243)4.02380427
54short-chain fatty acid metabolic process (GO:0046459)3.99750978
55positive regulation of protein autophosphorylation (GO:0031954)3.97827959
56L-phenylalanine metabolic process (GO:0006558)3.94404760
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.94404760
58negative regulation of cytosolic calcium ion concentration (GO:0051481)3.94377899
59branched-chain amino acid metabolic process (GO:0009081)3.90500596
60detection of calcium ion (GO:0005513)3.88612469
61vitamin D metabolic process (GO:0042359)3.88387659
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84756476
63negative regulation of hormone metabolic process (GO:0032351)3.83780316
64positive regulation of glycogen biosynthetic process (GO:0045725)3.78558312
65detection of temperature stimulus (GO:0016048)3.73519626
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72143564
67L-phenylalanine catabolic process (GO:0006559)3.72143564
682-oxoglutarate metabolic process (GO:0006103)3.68980431
69valine metabolic process (GO:0006573)3.68878459
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.68582183
71metanephric epithelium development (GO:0072207)3.67836111
72glandular epithelial cell differentiation (GO:0002067)3.67527532
73negative regulation of glycogen metabolic process (GO:0070874)3.67325741
74actin filament depolymerization (GO:0030042)3.66304560
75inositol phosphate catabolic process (GO:0071545)3.65642386
76type B pancreatic cell development (GO:0003323)3.62958243
77NADH metabolic process (GO:0006734)3.61339171
78cellular modified amino acid catabolic process (GO:0042219)3.58472441
79toxin transport (GO:1901998)3.58266375
80signal peptide processing (GO:0006465)3.57892435
81fructose metabolic process (GO:0006000)3.57711894
82water-soluble vitamin biosynthetic process (GO:0042364)3.55424296
83peptide biosynthetic process (GO:0043043)3.47164577
84* sodium ion transport (GO:0006814)3.46017799
85aromatic amino acid family catabolic process (GO:0009074)3.45978111
86inositol phosphate dephosphorylation (GO:0046855)3.45436327
87phosphorylated carbohydrate dephosphorylation (GO:0046838)3.45436327
88phosphate ion homeostasis (GO:0055062)3.45380172
89trivalent inorganic anion homeostasis (GO:0072506)3.45380172
90glycerophospholipid catabolic process (GO:0046475)3.44265718
91L-alpha-amino acid transmembrane transport (GO:1902475)3.40956511
92regulation of insulin secretion (GO:0050796)3.40823412
93auditory receptor cell differentiation (GO:0042491)3.37903688
94chemosensory behavior (GO:0007635)3.36716597
95positive regulation of glycogen metabolic process (GO:0070875)3.34274888
96regulation of glycolytic process (GO:0006110)3.31051283
97respiratory chain complex IV assembly (GO:0008535)3.30475214
98neuronal action potential (GO:0019228)3.29296314
99positive regulation of insulin receptor signaling pathway (GO:0046628)3.29112167
100positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.29045549
101adenosine metabolic process (GO:0046085)3.28157136
102nephron tubule development (GO:0072080)3.27160518
103xenobiotic catabolic process (GO:0042178)3.26265207
104modified amino acid transport (GO:0072337)3.25098794
105positive regulation of hormone secretion (GO:0046887)3.24404225
106pyrimidine ribonucleoside catabolic process (GO:0046133)3.24110680
107acetyl-CoA metabolic process (GO:0006084)3.21427769
108membrane repolarization (GO:0086009)3.19997576
109regulation of energy homeostasis (GO:2000505)3.19239990
110homocysteine metabolic process (GO:0050667)3.18993851
111fatty acid beta-oxidation (GO:0006635)3.18898985
112sodium ion export (GO:0071436)3.17156581
113indole-containing compound catabolic process (GO:0042436)3.16881819
114indolalkylamine catabolic process (GO:0046218)3.16881819
115tryptophan catabolic process (GO:0006569)3.16881819
116serine family amino acid catabolic process (GO:0009071)3.16454452
117regulation of peptide hormone secretion (GO:0090276)3.16094834
118regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.15783779
119potassium ion export (GO:0071435)3.15678477
120branched-chain amino acid catabolic process (GO:0009083)3.13832913
121glutathione metabolic process (GO:0006749)3.11218690
122positive regulation of vasodilation (GO:0045909)3.09916076
123amino-acid betaine metabolic process (GO:0006577)3.09787646
124regulation of peptide secretion (GO:0002791)3.08681417
125peptide hormone secretion (GO:0030072)3.07923929
126cellular ketone body metabolic process (GO:0046950)3.07692013
127peptide hormone processing (GO:0016486)3.05293689
128cellular potassium ion homeostasis (GO:0030007)3.04330813
129phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.04278620
130dendritic spine morphogenesis (GO:0060997)3.03315015
131phenylpropanoid metabolic process (GO:0009698)3.02050029
132proline metabolic process (GO:0006560)3.01436328
133nucleoside diphosphate catabolic process (GO:0009134)3.01253789
134negative regulation of neurological system process (GO:0031645)2.99947018
135positive regulation of TOR signaling (GO:0032008)2.99496564
136peptide secretion (GO:0002790)2.97310498
137tricarboxylic acid cycle (GO:0006099)2.97279797
138response to parathyroid hormone (GO:0071107)2.96817167
139response to glucose (GO:0009749)2.96338169
140cytochrome complex assembly (GO:0017004)2.95969563
141oxaloacetate metabolic process (GO:0006107)2.95734008
142embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95341589
143tryptophan metabolic process (GO:0006568)2.94438085
144polyol catabolic process (GO:0046174)2.94149368
145beta-amyloid metabolic process (GO:0050435)2.93584297
146cell volume homeostasis (GO:0006884)2.93418771
147carnitine metabolic process (GO:0009437)2.92297589
148regulation of calcium ion-dependent exocytosis (GO:0017158)2.91797638
149lipid oxidation (GO:0034440)2.91080884
150positive regulation of nitric-oxide synthase activity (GO:0051000)2.90250074
151cellular response to zinc ion (GO:0071294)2.90108182
152serine family amino acid metabolic process (GO:0009069)2.89644042
153fatty acid oxidation (GO:0019395)2.89442421
154macroautophagy (GO:0016236)2.88142344
155response to growth hormone (GO:0060416)2.87391430
156renal tubule development (GO:0061326)2.86795049
157regulation of protein glycosylation (GO:0060049)2.86543647
158mesenchymal cell differentiation involved in renal system development (GO:2001012)2.83971959
159mesenchymal cell differentiation involved in kidney development (GO:0072161)2.83971959
160righting reflex (GO:0060013)2.83504625
161regulation of acrosome reaction (GO:0060046)2.83486912
162brain morphogenesis (GO:0048854)2.83093369
163cytidine deamination (GO:0009972)2.80716704
164cytidine metabolic process (GO:0046087)2.80716704
165cytidine catabolic process (GO:0006216)2.80716704
166response to hexose (GO:0009746)2.80477259
167negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.80007068
168aromatic amino acid family metabolic process (GO:0009072)2.79052459
169* sodium ion transmembrane transport (GO:0035725)2.79037256
170negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.76980139
171regulation of hormone secretion (GO:0046883)2.76713346
172positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.75992063
173astrocyte differentiation (GO:0048708)2.75645210
174kidney morphogenesis (GO:0060993)2.75487698
175response to phenylpropanoid (GO:0080184)2.75250300
176fatty acid catabolic process (GO:0009062)2.74718957
177positive regulation of macroautophagy (GO:0016239)2.69428518
178glandular epithelial cell development (GO:0002068)2.67229462
179dentate gyrus development (GO:0021542)2.66002617
180positive regulation of meiosis (GO:0045836)2.64965181
181response to monosaccharide (GO:0034284)2.64444228
182regulation of carbohydrate catabolic process (GO:0043470)2.62785500
183regulation of cellular carbohydrate catabolic process (GO:0043471)2.62785500
184regulation of oxidative phosphorylation (GO:0002082)2.60895773
185calcium ion import (GO:0070509)2.60503036
186positive regulation of cellular carbohydrate metabolic process (GO:0010676)2.60064499
187regulation of autophagic vacuole assembly (GO:2000785)2.59158178
188positive regulation of glucose metabolic process (GO:0010907)2.57727348
189cell differentiation involved in metanephros development (GO:0072202)2.56126006
190regulation of protein autophosphorylation (GO:0031952)2.55273488
191peptide transport (GO:0015833)2.52501229
192platelet dense granule organization (GO:0060155)2.51858097
193hormone secretion (GO:0046879)2.50363287

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR2_21235772_ChIP-Seq_MCF-7_Human3.10400171
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.05603298
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.94775725
4VDR_22108803_ChIP-Seq_LS180_Human2.85361575
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.82794050
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.73655233
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.66765073
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.60974202
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50826244
10EGR1_19032775_ChIP-ChIP_M12_Human2.42762613
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27140130
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24119224
13ZNF274_21170338_ChIP-Seq_K562_Hela2.13943674
14ZNF263_19887448_ChIP-Seq_K562_Human2.11361112
15PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99495837
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89149960
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80808960
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.78943712
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.74086631
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.72844428
21EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.72082458
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.71881055
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.70866560
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66870488
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61912147
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60339268
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58979447
28SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55055855
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.54395935
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.54395935
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54058917
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53121759
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52398037
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.51653443
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51073385
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49424820
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48923547
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48637345
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.47864614
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.47723752
41CDX2_22108803_ChIP-Seq_LS180_Human1.46255930
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46228762
43GBX2_23144817_ChIP-Seq_PC3_Human1.45992739
44AHR_22903824_ChIP-Seq_MCF-7_Human1.43206301
45FUS_26573619_Chip-Seq_HEK293_Human1.42302406
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41173810
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.40979078
48TP53_22573176_ChIP-Seq_HFKS_Human1.40526899
49HTT_18923047_ChIP-ChIP_STHdh_Human1.40269905
50ER_23166858_ChIP-Seq_MCF-7_Human1.39543034
51* AR_25329375_ChIP-Seq_VCAP_Human1.39208667
52IGF1R_20145208_ChIP-Seq_DFB_Human1.39032388
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39004087
54CTCF_27219007_Chip-Seq_Bcells_Human1.38582841
55RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38433937
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.36662265
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36038463
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35322555
59ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32990357
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.31699032
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29201765
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.29068913
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28649942
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28519721
65TAF15_26573619_Chip-Seq_HEK293_Human1.27972140
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27887013
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.26694813
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26555099
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26551921
70SOX2_20726797_ChIP-Seq_SW620_Human1.25296989
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23896958
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23353474
73REST_21632747_ChIP-Seq_MESCs_Mouse1.23110872
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22943665
75FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22673624
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.22673624
77STAT3_23295773_ChIP-Seq_U87_Human1.22289528
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22215376
79FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.21918147
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.20868134
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19944259
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.18059204
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.17850063
84P53_22387025_ChIP-Seq_ESCs_Mouse1.17555522
85* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17253338
86SMAD4_21741376_ChIP-Seq_HESCs_Human1.15874691
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15710170
88CMYC_18555785_Chip-Seq_ESCs_Mouse1.15537085
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13540064
90CBP_20019798_ChIP-Seq_JUKART_Human1.13540064
91BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13530821
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.13525591
93TCF4_23295773_ChIP-Seq_U87_Human1.12592327
94NANOG_19829295_ChIP-Seq_ESCs_Human1.11731553
95SOX2_19829295_ChIP-Seq_ESCs_Human1.11731553
96RACK7_27058665_Chip-Seq_MCF-7_Human1.10785637
97* LXR_22292898_ChIP-Seq_THP-1_Human1.10234847
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.09656074
99SOX2_18555785_Chip-Seq_ESCs_Mouse1.08758609
100PHF8_20622853_ChIP-Seq_HELA_Human1.08080310
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.08018078
102SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07821915
103* SMAD4_21741376_ChIP-Seq_EPCs_Human1.07516435
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.06113805
105TBL1_22424771_ChIP-Seq_293T_Human1.05982421
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05742652
107* AR_20517297_ChIP-Seq_VCAP_Human1.05634670
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05404911
109SMAD4_21799915_ChIP-Seq_A2780_Human1.05195418
110FOXA1_25552417_ChIP-Seq_VCAP_Human1.05110805
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05045380
112TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04703879
113CBX2_27304074_Chip-Seq_ESCs_Mouse1.04626374
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.04464225
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04243847
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03577515
117CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03379823
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03106933
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02875086
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01446587
121WT1_19549856_ChIP-ChIP_CCG9911_Human1.01364884
122P300_18555785_Chip-Seq_ESCs_Mouse1.01207609
123CTCF_18555785_Chip-Seq_ESCs_Mouse1.00915578
124TCF4_22108803_ChIP-Seq_LS180_Human1.00912483
125CLOCK_20551151_ChIP-Seq_293T_Human1.00123473
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99253076
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.99109080
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.98772122
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.98498118
130RXR_22108803_ChIP-Seq_LS180_Human0.98375357
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98191463
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97986849
133TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.97895243
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97855720
135NFYA_21822215_ChIP-Seq_K562_Human0.97283894
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97141117
137PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97097288
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97071790
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96913034
140CRX_20693478_ChIP-Seq_RETINA_Mouse0.96856394
141NFYB_21822215_ChIP-Seq_K562_Human0.96835203
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96253619
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.96071939
144NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95601837
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95546797
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.95385373
147TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94917150
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.93139412
149CJUN_26792858_Chip-Seq_BT549_Human0.92898431
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91286045
151BCAT_22108803_ChIP-Seq_LS180_Human0.90558465
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89851605
153CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88464394
154ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87248551
155REST_18959480_ChIP-ChIP_MESCs_Mouse0.86797817
156GATA4_25053715_ChIP-Seq_YYC3_Human0.86509779
157PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84894587
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84570054
159KDM2B_26808549_Chip-Seq_K562_Human0.84248086
160P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84216932
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84203322
162BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83547998
163TRIM28_21343339_ChIP-Seq_HEK293_Human0.83354384
164OCT4_20526341_ChIP-Seq_ESCs_Human0.83306680
165HNF4A_19822575_ChIP-Seq_HepG2_Human0.81596929
166AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79872711
167* PRDM14_20953172_ChIP-Seq_ESCs_Human0.79473674
168GATA6_25053715_ChIP-Seq_YYC3_Human0.78862785
169P300_19829295_ChIP-Seq_ESCs_Human0.78846913
170OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78839205
171SA1_27219007_Chip-Seq_Bcells_Human0.78474832
172PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.78196831
173DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77888627
174* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76356218
175* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.75690432
176PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75284633

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation5.51275244
2MP0005360_urolithiasis5.12416132
3MP0002735_abnormal_chemical_nociception4.92380494
4MP0001968_abnormal_touch/_nociception4.53867449
5MP0002736_abnormal_nociception_after4.34558479
6MP0003195_calcinosis3.78659860
7MP0009780_abnormal_chondrocyte_physiolo3.76639758
8MP0005332_abnormal_amino_acid3.75917984
9MP0002909_abnormal_adrenal_gland3.75731925
10MP0003787_abnormal_imprinting3.73406920
11MP0002163_abnormal_gland_morphology3.61890007
12MP0005379_endocrine/exocrine_gland_phen3.53815238
13MP0001986_abnormal_taste_sensitivity3.42030036
14MP0001756_abnormal_urination3.33177005
15MP0004019_abnormal_vitamin_homeostasis3.23197910
16MP0009643_abnormal_urine_homeostasis3.19881027
17MP0001765_abnormal_ion_homeostasis3.19754653
18MP0002139_abnormal_hepatobiliary_system3.05923103
19MP0001944_abnormal_pancreas_morphology2.84280954
20MP0004858_abnormal_nervous_system2.67477901
21MP0005636_abnormal_mineral_homeostasis2.66322587
22MP0002733_abnormal_thermal_nociception2.64577369
23MP0005220_abnormal_exocrine_pancreas2.60856885
24MP0002138_abnormal_hepatobiliary_system2.56540382
25MP0002693_abnormal_pancreas_physiology2.55191701
26MP0004270_analgesia2.50545012
27MP0002734_abnormal_mechanical_nocicepti2.43504476
28MP0002136_abnormal_kidney_physiology2.41328051
29MP0003122_maternal_imprinting2.28498067
30MP0003123_paternal_imprinting2.21825922
31MP0000013_abnormal_adipose_tissue2.11250496
32MP0001970_abnormal_pain_threshold2.09539575
33MP0006072_abnormal_retinal_apoptosis2.02802339
34MP0008877_abnormal_DNA_methylation2.00439891
35MP0000538_abnormal_urinary_bladder1.89415066
36MP0005377_hearing/vestibular/ear_phenot1.85038040
37MP0003878_abnormal_ear_physiology1.85038040
38MP0002078_abnormal_glucose_homeostasis1.80863448
39MP0008961_abnormal_basal_metabolism1.80569548
40MP0006276_abnormal_autonomic_nervous1.78521932
41MP0008875_abnormal_xenobiotic_pharmacok1.77084909
42MP0001958_emphysema1.72320263
43MP0003806_abnormal_nucleotide_metabolis1.68273512
44MP0005058_abnormal_lysosome_morphology1.67365168
45MP0005645_abnormal_hypothalamus_physiol1.64286995
46MP0010329_abnormal_lipoprotein_level1.59189969
47MP0005646_abnormal_pituitary_gland1.59012716
48MP0001270_distended_abdomen1.57652534
49MP0000462_abnormal_digestive_system1.50505307
50MP0004885_abnormal_endolymph1.42665238
51MP0003121_genomic_imprinting1.35959663
52MP0005584_abnormal_enzyme/coenzyme_acti1.35704961
53MP0005085_abnormal_gallbladder_physiolo1.35258982
54MP0002638_abnormal_pupillary_reflex1.34359164
55MP0002090_abnormal_vision1.33928296
56MP0010678_abnormal_skin_adnexa1.31674123
57MP0002876_abnormal_thyroid_physiology1.30564113
58MP0000230_abnormal_systemic_arterial1.29917149
59MP0002067_abnormal_sensory_capabilities1.28274918
60MP0003186_abnormal_redox_activity1.25983615
61MP0003011_delayed_dark_adaptation1.23558921
62MP0008260_abnormal_autophagy1.23092867
63MP0001501_abnormal_sleep_pattern1.22160192
64MP0003953_abnormal_hormone_level1.19946458
65MP0003329_amyloid_beta_deposits1.18819042
66MP0006036_abnormal_mitochondrial_physio1.18589865
67MP0005083_abnormal_biliary_tract1.18421167
68MP0003252_abnormal_bile_duct1.16954992
69MP0005365_abnormal_bile_salt1.14847633
70MP0005551_abnormal_eye_electrophysiolog1.13024624
71MP0005535_abnormal_body_temperature1.10765955
72MP0002928_abnormal_bile_duct1.05879634
73MP0005448_abnormal_energy_balance1.05243761
74MP0000747_muscle_weakness1.02761710
75MP0000427_abnormal_hair_cycle0.98922462
76MP0000003_abnormal_adipose_tissue0.98658376
77MP0003656_abnormal_erythrocyte_physiolo0.96910380
78MP0005253_abnormal_eye_physiology0.95084631
79MP0002168_other_aberrant_phenotype0.94443929
80MP0002277_abnormal_respiratory_mucosa0.94277839
81MP0005319_abnormal_enzyme/_coenzyme0.93216592
82MP0010234_abnormal_vibrissa_follicle0.91867694
83MP0005084_abnormal_gallbladder_morpholo0.90973140
84MP0009745_abnormal_behavioral_response0.89627803
85MP0005367_renal/urinary_system_phenotyp0.89586820
86MP0000516_abnormal_urinary_system0.89586820
87MP0002135_abnormal_kidney_morphology0.88991587
88MP0003300_gastrointestinal_ulcer0.88004248
89MP0002272_abnormal_nervous_system0.87985018
90MP0002557_abnormal_social/conspecific_i0.86988866
91MP0000639_abnormal_adrenal_gland0.82504418
92MP0000534_abnormal_ureter_morphology0.82473427
93MP0002751_abnormal_autonomic_nervous0.79617610
94MP0001905_abnormal_dopamine_level0.79534989
95MP0002938_white_spotting0.77621365
96MP0005386_behavior/neurological_phenoty0.76593568
97MP0004924_abnormal_behavior0.76593568
98MP0010386_abnormal_urinary_bladder0.75765368
99MP0000631_abnormal_neuroendocrine_gland0.75268323
100MP0003172_abnormal_lysosome_physiology0.74924741
101MP0002896_abnormal_bone_mineralization0.74010786
102MP0004142_abnormal_muscle_tone0.73000498
103MP0002102_abnormal_ear_morphology0.72457970
104MP0003646_muscle_fatigue0.71776630
105MP0005165_increased_susceptibility_to0.71719521
106MP0005075_abnormal_melanosome_morpholog0.71710198
107MP0002184_abnormal_innervation0.69486233
108MP0001764_abnormal_homeostasis0.69361673
109MP0002572_abnormal_emotion/affect_behav0.69205112
110MP0004859_abnormal_synaptic_plasticity0.68651488
111MP0003283_abnormal_digestive_organ0.68624018
112MP0000604_amyloidosis0.68443863
113MP0005389_reproductive_system_phenotype0.68423804
114MP0005174_abnormal_tail_pigmentation0.68174763
115MP0004742_abnormal_vestibular_system0.67907461
116MP0002160_abnormal_reproductive_system0.67679574
117MP0004085_abnormal_heartbeat0.67666055
118MP0003879_abnormal_hair_cell0.66196911
119MP0008874_decreased_physiological_sensi0.64802306
120MP0005452_abnormal_adipose_tissue0.63431571
121MP0000749_muscle_degeneration0.62752121
122MP0000383_abnormal_hair_follicle0.62312268
123MP0001664_abnormal_digestion0.62092149
124MP0000372_irregular_coat_pigmentation0.62034174
125MP0002254_reproductive_system_inflammat0.61939838
126MP0001661_extended_life_span0.61598636
127MP0002971_abnormal_brown_adipose0.61089109
128MP0002064_seizures0.61071904
129MP0000751_myopathy0.59961335
130MP0001666_abnormal_nutrient_absorption0.59328915
131MP0002118_abnormal_lipid_homeostasis0.59196383
132MP0009642_abnormal_blood_homeostasis0.58988214
133MP0002069_abnormal_eating/drinking_beha0.58672771
134MP0005451_abnormal_body_composition0.58226961
135MP0004147_increased_porphyrin_level0.56556156
136MP0002837_dystrophic_cardiac_calcinosis0.54627280
137MP0002089_abnormal_postnatal_growth/wei0.53282762
138MP0003638_abnormal_response/metabolism_0.52318187
139MP0003633_abnormal_nervous_system0.51630115
140MP0004484_altered_response_of0.51213676
141MP0008872_abnormal_physiological_respon0.50317699
142MP0003191_abnormal_cellular_cholesterol0.50064036
143MP0003959_abnormal_lean_body0.50023860
144MP0003183_abnormal_peptide_metabolism0.49896951
145MP0010771_integument_phenotype0.48822884
146MP0008775_abnormal_heart_ventricle0.48240440
147MP0002972_abnormal_cardiac_muscle0.48129036
148MP0003635_abnormal_synaptic_transmissio0.46995100
149MP0002229_neurodegeneration0.46385098
150MP0001984_abnormal_olfaction0.45918724
151MP0003634_abnormal_glial_cell0.44554217
152MP0001440_abnormal_grooming_behavior0.44463400
153MP0005666_abnormal_adipose_tissue0.44397600
154MP0002066_abnormal_motor_capabilities/c0.44330137
155MP0009046_muscle_twitch0.42861383

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)7.98444387
2Metabolic alkalosis (HP:0200114)7.77603354
3Hypokalemic alkalosis (HP:0001949)7.63021447
4Hyperinsulinemic hypoglycemia (HP:0000825)7.53981929
5Increased circulating renin level (HP:0000848)7.44463024
6Hypoglycemic coma (HP:0001325)7.23018582
7Hyperactive renin-angiotensin system (HP:0000841)6.68131504
8Polyuria (HP:0000103)6.64072821
9Abnormality of chloride homeostasis (HP:0011422)6.61526256
10* Hypomagnesemia (HP:0002917)6.26617393
11Abnormal urine output (HP:0012590)6.16432372
12Gout (HP:0001997)5.95056009
13Abnormality of endocrine pancreas physiology (HP:0012093)5.79315323
14Abnormality of the pancreatic islet cells (HP:0006476)5.79315323
15Abnormality of renal excretion (HP:0011036)5.71608035
16* Abnormality of magnesium homeostasis (HP:0004921)5.52679660
17Hyperglycemia (HP:0003074)5.43482444
18Symptomatic seizures (HP:0011145)5.39061349
19Abnormal drinking behavior (HP:0030082)5.23006446
20Polydipsia (HP:0001959)5.23006446
21Renal salt wasting (HP:0000127)5.12089072
22Hyperaldosteronism (HP:0000859)5.01134298
23Alkalosis (HP:0001948)4.99076636
24Tetany (HP:0001281)4.79329537
25Abnormality of renin-angiotensin system (HP:0000847)4.52298323
26Large for gestational age (HP:0001520)4.48980960
27Late onset (HP:0003584)4.29678721
28Increased purine levels (HP:0004368)4.26882547
29Hyperuricemia (HP:0002149)4.26882547
30Proximal tubulopathy (HP:0000114)4.10962570
31Prominent metopic ridge (HP:0005487)4.03251119
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.89717215
33Insulin-resistant diabetes mellitus (HP:0000831)3.87757041
34Pancreatic islet-cell hyperplasia (HP:0004510)3.81551659
35Hypokalemia (HP:0002900)3.81103949
36Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.66272436
37Abnormality of the metopic suture (HP:0005556)3.61217501
38Abnormality of purine metabolism (HP:0004352)3.59538445
39Hypothermia (HP:0002045)3.58206822
40Hypercalciuria (HP:0002150)3.57552404
41Hyperglycinuria (HP:0003108)3.53268741
42Enlarged penis (HP:0000040)3.24212811
43Generalized aminoaciduria (HP:0002909)3.22870470
44EEG with generalized epileptiform discharges (HP:0011198)3.17881670
45Abnormality of potassium homeostasis (HP:0011042)3.15511516
46Epileptiform EEG discharges (HP:0011182)3.10113531
47Hypsarrhythmia (HP:0002521)3.03527022
48Renal tubular acidosis (HP:0001947)2.91639896
49Adrenal overactivity (HP:0002717)2.89114231
50Abnormal pancreas size (HP:0012094)2.87307128
51Abnormality of fatty-acid metabolism (HP:0004359)2.81508572
52Abnormality of serine family amino acid metabolism (HP:0010894)2.80407192
53Abnormality of glycine metabolism (HP:0010895)2.80407192
54Hydroxyprolinuria (HP:0003080)2.79729986
55Abnormality of proline metabolism (HP:0010907)2.79729986
56Glycosuria (HP:0003076)2.78644153
57Abnormality of urine glucose concentration (HP:0011016)2.78644153
58Ketoacidosis (HP:0001993)2.77922005
59Type I diabetes mellitus (HP:0100651)2.71116324
60Abnormality of nucleobase metabolism (HP:0010932)2.67141868
61Abnormality of sodium homeostasis (HP:0010931)2.66367155
62Nephrocalcinosis (HP:0000121)2.65145530
63Hyperphosphaturia (HP:0003109)2.61021025
64Metaphyseal dysplasia (HP:0100255)2.58504434
65Pheochromocytoma (HP:0002666)2.52724505
66Hyperphosphatemia (HP:0002905)2.50590083
67Neoplasm of the adrenal cortex (HP:0100641)2.50169510
68Tongue fasciculations (HP:0001308)2.49543570
69Muscular hypotonia of the trunk (HP:0008936)2.49414647
70Neonatal onset (HP:0003623)2.46908069
71Delayed epiphyseal ossification (HP:0002663)2.46555144
72Hypokinesia (HP:0002375)2.43878184
73Hyponatremia (HP:0002902)2.43638312
74Potter facies (HP:0002009)2.41985122
75Facial shape deformation (HP:0011334)2.41985122
76Abnormality of vitamin B metabolism (HP:0004340)2.41904626
77Hemiparesis (HP:0001269)2.41019246
78Ketosis (HP:0001946)2.40281212
79Insulin resistance (HP:0000855)2.36960292
80Abnormal urine phosphate concentration (HP:0012599)2.36385472
81Hepatic necrosis (HP:0002605)2.35281536
82Unilateral renal agenesis (HP:0000122)2.32774644
83Methylmalonic acidemia (HP:0002912)2.30507517
84Neuroendocrine neoplasm (HP:0100634)2.28450149
85Nuclear cataract (HP:0100018)2.26484892
86Nephrolithiasis (HP:0000787)2.22695559
87Segmental peripheral demyelination/remyelination (HP:0003481)2.17666696
88Dehydration (HP:0001944)2.16229609
89Hematochezia (HP:0002573)2.14869925
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.13974325
91Bicornuate uterus (HP:0000813)2.12223317
92Hepatoblastoma (HP:0002884)2.11584594
93Conjunctival hamartoma (HP:0100780)2.11302809
94Hyperthyroidism (HP:0000836)2.11200463
95Abnormal sex determination (HP:0012244)2.10893127
96Sex reversal (HP:0012245)2.10893127
97Vomiting (HP:0002013)2.10369077
98Agitation (HP:0000713)2.10358545
99Muscle fibrillation (HP:0010546)2.10352741
100Abnormality of the renal cortex (HP:0011035)2.08891942
101Testicular neoplasm (HP:0010788)2.08716306
102Hypophosphatemia (HP:0002148)2.08158842
103Progressive macrocephaly (HP:0004481)2.06084490
104Malnutrition (HP:0004395)2.04585765
105Exocrine pancreatic insufficiency (HP:0001738)2.03644905
106Abnormality of the vocal cords (HP:0008777)2.00311450
107Hamartoma of the eye (HP:0010568)1.99812832
108Vacuolated lymphocytes (HP:0001922)1.95390834
109Abnormality of the costochondral junction (HP:0000919)1.94811521
110Axonal loss (HP:0003447)1.93955951
111Vascular calcification (HP:0004934)1.92782571
112Metaphyseal cupping (HP:0003021)1.89013313
113Abnormality of vitamin metabolism (HP:0100508)1.88956119
114Hyperglycinemia (HP:0002154)1.88776114
115Hyperammonemia (HP:0001987)1.88278606
116Renal tubular dysfunction (HP:0000124)1.87157026
117Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86572808
118Albinism (HP:0001022)1.85095215
119Ventricular fibrillation (HP:0001663)1.85065678
120Aplasia/hypoplasia of the uterus (HP:0008684)1.84862821
121Myokymia (HP:0002411)1.84097924
122Ulnar claw (HP:0001178)1.83819797
123Hypotension (HP:0002615)1.83092453
124Chondrocalcinosis (HP:0000934)1.82902689
125Rickets (HP:0002748)1.81954593
126Xanthomatosis (HP:0000991)1.81445824
127Progressive neurologic deterioration (HP:0002344)1.81387970
128Dicarboxylic aciduria (HP:0003215)1.81385797
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81385797
130Medial flaring of the eyebrow (HP:0010747)1.80859436
131Glomerulosclerosis (HP:0000096)1.80637769
132Abnormal tarsal ossification (HP:0008369)1.79086669
133Abnormality of calcium-phosphate metabolism (HP:0100530)1.78402110
134Downturned corners of mouth (HP:0002714)1.78293120
135Tubular atrophy (HP:0000092)1.77539177
136Gaze-evoked nystagmus (HP:0000640)1.77403693
137Abnormality of renal resorption (HP:0011038)1.75638790
138Double outlet right ventricle (HP:0001719)1.75576646
139Congenital malformation of the right heart (HP:0011723)1.75576646
140Metabolic acidosis (HP:0001942)1.75454733
141Retinal atrophy (HP:0001105)1.74535430
142Insidious onset (HP:0003587)1.73671570
143Termporal pattern (HP:0011008)1.73671570
144Renal cortical cysts (HP:0000803)1.72018912
145Nausea (HP:0002018)1.71690607
146Neoplasm of the adrenal gland (HP:0100631)1.71416299
147Delayed CNS myelination (HP:0002188)1.70911063
148Macroorchidism (HP:0000053)1.70550573
149Increased CSF protein (HP:0002922)1.69986284
150Disproportionate short-trunk short stature (HP:0003521)1.68955493
151Lethargy (HP:0001254)1.68894646
152Impaired pain sensation (HP:0007328)1.68783144
153Abnormality of pain sensation (HP:0010832)1.68783144
154Abnormality of Sharpey fibers (HP:0100685)1.68490559
155Diminished movement (HP:0002374)1.68154808
156Cardiovascular calcification (HP:0011915)1.68062957
157Irritability (HP:0000737)1.67842214
158Tubulointerstitial fibrosis (HP:0005576)1.66779727
159Intestinal atresia (HP:0011100)1.66538626
160Generalized muscle weakness (HP:0003324)1.66400483
161Methylmalonic aciduria (HP:0012120)1.64626028
162Decreased circulating renin level (HP:0003351)1.64251419
163Abnormality of polysaccharide metabolism (HP:0011012)1.64245241
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.64245241
165Abnormality of mucopolysaccharide metabolism (HP:0011020)1.64245241
166Enlarged kidneys (HP:0000105)1.61979511
167Abnormal eating behavior (HP:0100738)1.61907019
168Urinary glycosaminoglycan excretion (HP:0003541)1.61416499
169Mucopolysacchariduria (HP:0008155)1.61416499
170Pancreatic cysts (HP:0001737)1.60291178
171Sensorimotor neuropathy (HP:0007141)1.58798722

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.34602864
2WNK37.23965350
3OXSR16.03205022
4FGFR24.27122160
5STK393.62870587
6PASK3.13221353
7SGK4942.36603850
8SGK2232.36603850
9NTRK12.20994601
10KSR22.02385695
11MAP3K21.88408363
12MAP4K21.84252686
13NEK11.83660158
14SGK21.82738691
15GRK51.81096064
16BCKDK1.79998468
17GRK11.77377803
18STK38L1.74958782
19RIPK41.71621311
20WNK11.66148753
21INSRR1.55040689
22NLK1.54327351
23PDK41.49163133
24PDK31.49163133
25LIMK11.43800925
26BMPR1B1.43400265
27MINK11.42953501
28SGK31.41694329
29HIPK21.40778447
30MAP3K91.35350952
31EIF2AK31.34647131
32SIK31.33960271
33PNCK1.32229710
34ACVR1B1.32172125
35TRPM71.27390981
36PINK11.22324367
37ARAF1.21666465
38TNIK1.12434497
39MST41.11604565
40LMTK21.05215316
41TAOK11.03701338
42RET1.01329509
43PTK2B0.99334143
44PRKAA20.98136718
45STK30.97241157
46AKT30.97108660
47MATK0.96951850
48MARK30.95652651
49MAP3K120.94460642
50FER0.92369369
51PDK20.92344726
52EPHB10.91299418
53STK160.89935849
54DAPK20.89667370
55CAMK2D0.88842675
56FGFR40.88182067
57EPHA30.87321297
58MST1R0.85587432
59STK240.80506235
60CSNK1G10.79433224
61STK110.75427245
62MAP2K10.75148107
63CASK0.74818996
64STK380.74029331
65TESK10.68479389
66ERBB30.68032047
67BLK0.67848189
68LRRK20.67628360
69MAPKAPK30.65944014
70MAP3K10.63988774
71FRK0.62878240
72TNK20.62625645
73PAK60.61134312
74PKN20.60679611
75ZAK0.59723378
76PTK20.58522359
77MAP2K20.58271068
78RPS6KA20.50729655
79MAP2K40.49484709
80CSNK1G30.48722955
81PRKG10.48321285
82CAMK1G0.46905190
83PRKD30.46257236
84PRKG20.45878175
85PLK20.45259952
86MAP3K110.44021261
87PDPK10.43192335
88IKBKB0.43044723
89PLK30.42463828
90STK40.42279149
91SGK10.42059101
92CSNK1G20.40283160
93ROCK10.39579205
94LATS20.38880461
95NTRK30.38643820
96FLT30.38587243
97PHKG10.38233683
98PHKG20.38233683
99CAMKK20.38198436
100TAOK30.37907662
101PRKCZ0.37688383
102CDK140.37632768
103PAK30.37497104
104TAF10.35799143
105TESK20.35189049
106PDK10.33971197
107MET0.32684082
108PRKAA10.32295534
109CDK50.32208002
110MAP2K70.31800422
111MAPKAPK50.31775352
112PRKCD0.31757015
113GSK3A0.31272314
114EIF2AK10.30674595
115CSNK1A10.29086678
116KSR10.28382779
117YES10.28360398
118BCR0.28107217
119FGFR30.27995696
120PIM20.27450204
121ADRBK10.27322412
122CAMK2A0.26632500
123IRAK10.25837611
124SCYL20.25347166
125BRSK20.25248843
126CDK30.25184115
127PRKACG0.24801181
128PRKACB0.24789866
129PRKACA0.24588030
130PRKCE0.24366969
131ITK0.23858087
132ADRBK20.23855522
133MYLK0.22954019
134ABL20.22415806
135NEK90.22307704
136MAP2K60.21998550
137PRKCG0.21935984
138PRKCH0.20750571
139PRKCQ0.20687826
140IRAK40.19633055
141DAPK10.19618027
142IRAK20.19565526
143MAPK110.19132675
144PRKCI0.19095641
145MAP3K70.18170739
146MAP3K40.17973376
147GRK60.16180520
148NME20.15543553
149PRKCA0.15521270
150EPHB20.15446927

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.23079359
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.56320483
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.32512304
4* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.23518061
5Butanoate metabolism_Homo sapiens_hsa006503.16292020
6Collecting duct acid secretion_Homo sapiens_hsa049662.99287716
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73085888
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72765337
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71006555
10Propanoate metabolism_Homo sapiens_hsa006402.61544116
11Protein export_Homo sapiens_hsa030602.59907782
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53969455
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48174084
14Pyruvate metabolism_Homo sapiens_hsa006202.37594266
15* Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33009784
16Type II diabetes mellitus_Homo sapiens_hsa049302.23733774
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.19033898
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15375705
19Peroxisome_Homo sapiens_hsa041462.14670203
20Fatty acid degradation_Homo sapiens_hsa000711.87492690
21Vitamin B6 metabolism_Homo sapiens_hsa007501.85750845
22* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.80028210
23Sulfur metabolism_Homo sapiens_hsa009201.79722730
24Synaptic vesicle cycle_Homo sapiens_hsa047211.76987930
25Type I diabetes mellitus_Homo sapiens_hsa049401.76928487
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76270574
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74717117
28Oxidative phosphorylation_Homo sapiens_hsa001901.63281406
29Tryptophan metabolism_Homo sapiens_hsa003801.62326494
30Carbon metabolism_Homo sapiens_hsa012001.57025915
31Fatty acid metabolism_Homo sapiens_hsa012121.44107811
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39520162
33Vitamin digestion and absorption_Homo sapiens_hsa049771.38268181
34Renin-angiotensin system_Homo sapiens_hsa046141.37925642
35Circadian rhythm_Homo sapiens_hsa047101.30867615
36* Bile secretion_Homo sapiens_hsa049761.28381823
37beta-Alanine metabolism_Homo sapiens_hsa004101.28380135
38Fructose and mannose metabolism_Homo sapiens_hsa000511.28180433
39Parkinsons disease_Homo sapiens_hsa050121.23919524
40Ovarian steroidogenesis_Homo sapiens_hsa049131.22999263
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22938446
42Glutathione metabolism_Homo sapiens_hsa004801.20775370
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19437997
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.18496716
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18422109
46ABC transporters_Homo sapiens_hsa020101.17873249
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16990810
48Starch and sucrose metabolism_Homo sapiens_hsa005001.16750974
49Glycerolipid metabolism_Homo sapiens_hsa005611.14802531
50mTOR signaling pathway_Homo sapiens_hsa041501.11657614
51Arginine and proline metabolism_Homo sapiens_hsa003301.01219223
52Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00617519
53* Protein digestion and absorption_Homo sapiens_hsa049740.98983121
54Renin secretion_Homo sapiens_hsa049240.94034165
55Arginine biosynthesis_Homo sapiens_hsa002200.91854789
56* Mineral absorption_Homo sapiens_hsa049780.88950393
57Vibrio cholerae infection_Homo sapiens_hsa051100.88399996
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87136009
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83749611
60Other glycan degradation_Homo sapiens_hsa005110.83582578
61Ether lipid metabolism_Homo sapiens_hsa005650.82239431
62Steroid biosynthesis_Homo sapiens_hsa001000.82026209
63Fatty acid elongation_Homo sapiens_hsa000620.80611749
64PPAR signaling pathway_Homo sapiens_hsa033200.80027920
65Lysosome_Homo sapiens_hsa041420.75608280
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.73158473
67Glucagon signaling pathway_Homo sapiens_hsa049220.71893336
68Gastric acid secretion_Homo sapiens_hsa049710.70739508
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70150097
70Alzheimers disease_Homo sapiens_hsa050100.70024562
71Phenylalanine metabolism_Homo sapiens_hsa003600.69502954
72Biosynthesis of amino acids_Homo sapiens_hsa012300.69140665
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68262718
74Phototransduction_Homo sapiens_hsa047440.67706374
75Taste transduction_Homo sapiens_hsa047420.67544954
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67251768
77Retinol metabolism_Homo sapiens_hsa008300.64269015
78Amphetamine addiction_Homo sapiens_hsa050310.64114087
79Linoleic acid metabolism_Homo sapiens_hsa005910.63828382
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62981431
81Insulin resistance_Homo sapiens_hsa049310.62066373
82AMPK signaling pathway_Homo sapiens_hsa041520.61835231
83Serotonergic synapse_Homo sapiens_hsa047260.59604079
84* Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58647871
85N-Glycan biosynthesis_Homo sapiens_hsa005100.56968901
86alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56529913
87Histidine metabolism_Homo sapiens_hsa003400.54215840
88GABAergic synapse_Homo sapiens_hsa047270.54116457
89Arachidonic acid metabolism_Homo sapiens_hsa005900.52846550
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52592476
91Lysine degradation_Homo sapiens_hsa003100.52367855
92Dopaminergic synapse_Homo sapiens_hsa047280.52156997
93Regulation of autophagy_Homo sapiens_hsa041400.50363971
94* Cardiac muscle contraction_Homo sapiens_hsa042600.50133359
95Huntingtons disease_Homo sapiens_hsa050160.49520297
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49392801
97Folate biosynthesis_Homo sapiens_hsa007900.49225348
98Circadian entrainment_Homo sapiens_hsa047130.48971659
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48769148
100Pentose phosphate pathway_Homo sapiens_hsa000300.47676404
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47207155
102Metabolic pathways_Homo sapiens_hsa011000.46884792
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45561903
104Choline metabolism in cancer_Homo sapiens_hsa052310.45365510
105Caffeine metabolism_Homo sapiens_hsa002320.45360057
106Thyroid cancer_Homo sapiens_hsa052160.43822415
107Phagosome_Homo sapiens_hsa041450.42391480
108* Pancreatic secretion_Homo sapiens_hsa049720.41091639
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39445855
110* Thyroid hormone synthesis_Homo sapiens_hsa049180.39180911
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38861864
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38366230
113Cocaine addiction_Homo sapiens_hsa050300.37180117
114Long-term depression_Homo sapiens_hsa047300.35946680
115Rheumatoid arthritis_Homo sapiens_hsa053230.35772368
116Basal transcription factors_Homo sapiens_hsa030220.34202022
117Galactose metabolism_Homo sapiens_hsa000520.31401626
118Selenocompound metabolism_Homo sapiens_hsa004500.28739244
119Tyrosine metabolism_Homo sapiens_hsa003500.27940970
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.27315226
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.27236261
122Nitrogen metabolism_Homo sapiens_hsa009100.27013509
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.26824060
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25762783
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.25373719
126Chemical carcinogenesis_Homo sapiens_hsa052040.23681888
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.22371006
128Insulin signaling pathway_Homo sapiens_hsa049100.22315505
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21697106
130Endometrial cancer_Homo sapiens_hsa052130.19791547
131Bladder cancer_Homo sapiens_hsa052190.19146962
132Sphingolipid metabolism_Homo sapiens_hsa006000.18924493
133Melanoma_Homo sapiens_hsa052180.18039756
134Endocytosis_Homo sapiens_hsa041440.17260076
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16307282
136Dorso-ventral axis formation_Homo sapiens_hsa043200.15471128
137Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14424160
138Glioma_Homo sapiens_hsa052140.10558235
139* Insulin secretion_Homo sapiens_hsa049110.10457400

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