FUT9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.47197305
2vocalization behavior (GO:0071625)5.36721807
3synaptic vesicle exocytosis (GO:0016079)5.18236318
4neuron cell-cell adhesion (GO:0007158)5.12856199
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12140029
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98036098
7locomotory exploration behavior (GO:0035641)4.94100741
8ionotropic glutamate receptor signaling pathway (GO:0035235)4.86070067
9glutamate secretion (GO:0014047)4.85393685
10neuronal action potential propagation (GO:0019227)4.69115149
11regulation of glutamate receptor signaling pathway (GO:1900449)4.68339594
12glutamate receptor signaling pathway (GO:0007215)4.57915183
13protein localization to synapse (GO:0035418)4.54702904
14gamma-aminobutyric acid transport (GO:0015812)4.49800394
15regulation of synaptic vesicle exocytosis (GO:2000300)4.49677929
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.48987417
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35739546
18synaptic transmission, glutamatergic (GO:0035249)4.32849684
19neurotransmitter secretion (GO:0007269)4.26528075
20cellular potassium ion homeostasis (GO:0030007)4.24376434
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.24156570
22neurotransmitter-gated ion channel clustering (GO:0072578)4.23211725
23neuron-neuron synaptic transmission (GO:0007270)4.19827700
24presynaptic membrane assembly (GO:0097105)4.10422590
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.08879727
26synaptic vesicle maturation (GO:0016188)4.06950151
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05921238
28exploration behavior (GO:0035640)4.03599500
29negative regulation of synaptic transmission, GABAergic (GO:0032229)4.00356640
30proline transport (GO:0015824)3.99897322
31pyrimidine nucleobase catabolic process (GO:0006208)3.97151243
32axon ensheathment in central nervous system (GO:0032291)3.95553834
33central nervous system myelination (GO:0022010)3.95553834
34layer formation in cerebral cortex (GO:0021819)3.95303612
35regulation of synaptic vesicle transport (GO:1902803)3.94173815
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90016917
37cerebellar granule cell differentiation (GO:0021707)3.88028484
38neuron recognition (GO:0008038)3.84462772
39presynaptic membrane organization (GO:0097090)3.83470487
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.83245694
41postsynaptic membrane organization (GO:0001941)3.79271631
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70535696
43regulation of neuronal synaptic plasticity (GO:0048168)3.68757105
44neurotransmitter transport (GO:0006836)3.68752055
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67472092
46membrane depolarization during action potential (GO:0086010)3.65107624
47positive regulation of membrane potential (GO:0045838)3.59640594
48response to histamine (GO:0034776)3.59031516
49sodium ion export (GO:0071436)3.57038323
50positive regulation of synapse maturation (GO:0090129)3.55312709
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.55024744
52regulation of postsynaptic membrane potential (GO:0060078)3.54296399
53amino acid import (GO:0043090)3.53810297
54regulation of synapse structural plasticity (GO:0051823)3.52186767
55cerebral cortex radially oriented cell migration (GO:0021799)3.52016596
56long-term memory (GO:0007616)3.50826376
57regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.49520245
58long-term synaptic potentiation (GO:0060291)3.49401826
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.47514650
60establishment of mitochondrion localization (GO:0051654)3.43881783
61dendritic spine morphogenesis (GO:0060997)3.42882313
62axonal fasciculation (GO:0007413)3.39551252
63regulation of neurotransmitter levels (GO:0001505)3.33222010
64central nervous system projection neuron axonogenesis (GO:0021952)3.32556816
65nucleobase catabolic process (GO:0046113)3.31063867
66cerebellar Purkinje cell differentiation (GO:0021702)3.30472341
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.29588373
68regulation of synaptic plasticity (GO:0048167)3.24180923
69positive regulation of dendritic spine development (GO:0060999)3.24010473
70startle response (GO:0001964)3.22786576
71adult walking behavior (GO:0007628)3.21819376
72neuronal ion channel clustering (GO:0045161)3.21640652
73transmission of nerve impulse (GO:0019226)3.21516366
74synapse assembly (GO:0007416)3.21073522
75potassium ion import (GO:0010107)3.20901057
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16283511
77response to auditory stimulus (GO:0010996)3.14299642
78regulation of dendritic spine morphogenesis (GO:0061001)3.13968270
79negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13819461
80auditory behavior (GO:0031223)3.13590786
81regulation of neurotransmitter secretion (GO:0046928)3.08861791
82L-amino acid import (GO:0043092)3.07220165
83positive regulation of synapse assembly (GO:0051965)3.07178169
84dendrite morphogenesis (GO:0048813)3.05583078
85synaptic vesicle endocytosis (GO:0048488)3.04991604
86neuromuscular synaptic transmission (GO:0007274)3.03452288
87membrane hyperpolarization (GO:0060081)3.01184752
88serotonin metabolic process (GO:0042428)3.00749922
89potassium ion homeostasis (GO:0055075)2.98755552
90cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.98038413
91cell communication by electrical coupling (GO:0010644)2.97844014
92synapse organization (GO:0050808)2.97163060
93membrane depolarization (GO:0051899)2.97161407
94mechanosensory behavior (GO:0007638)2.95862602
95regulation of vesicle fusion (GO:0031338)2.95673348
96regulation of respiratory system process (GO:0044065)2.94865420
97neurotransmitter uptake (GO:0001504)2.94470863
98behavioral defense response (GO:0002209)2.93665200
99behavioral fear response (GO:0001662)2.93665200
100regulation of synapse maturation (GO:0090128)2.93533244
101acidic amino acid transport (GO:0015800)2.93508153
102ATP hydrolysis coupled proton transport (GO:0015991)2.92056215
103energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.92056215
104positive regulation of neurotransmitter secretion (GO:0001956)2.90143339
105glycosphingolipid biosynthetic process (GO:0006688)2.88962065
106alanine transport (GO:0032328)2.88845136
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87310382
108synaptic transmission (GO:0007268)2.86289392
109positive regulation of potassium ion transmembrane transport (GO:1901381)2.86000771
110regulation of synaptic transmission, GABAergic (GO:0032228)2.85933804
111fear response (GO:0042596)2.85480935
112activation of protein kinase A activity (GO:0034199)2.85327460
113learning (GO:0007612)2.83507097
114C4-dicarboxylate transport (GO:0015740)2.83213078
115cellular sodium ion homeostasis (GO:0006883)2.83038494
116positive regulation of synaptic transmission (GO:0050806)2.82594376
117regulation of dendritic spine development (GO:0060998)2.82482533
118positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81721849
119cochlea development (GO:0090102)2.81068597
120regulation of neurotransmitter transport (GO:0051588)2.80749654

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.33885422
2GBX2_23144817_ChIP-Seq_PC3_Human3.98836551
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09732888
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04215328
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.98953072
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61251313
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56682407
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56682407
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50442660
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48596057
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.46190181
12REST_21632747_ChIP-Seq_MESCs_Mouse2.41064734
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40755909
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37572161
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.29589450
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28605125
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28158033
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24580429
19TAF15_26573619_Chip-Seq_HEK293_Human2.20200533
20AR_21572438_ChIP-Seq_LNCaP_Human2.14131355
21DROSHA_22980978_ChIP-Seq_HELA_Human2.03790050
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01668776
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01087709
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.98906518
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.98692723
26* RARB_27405468_Chip-Seq_BRAIN_Mouse1.98684232
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.89404907
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85635944
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85351868
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79827123
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79806307
32SMAD4_21799915_ChIP-Seq_A2780_Human1.79160298
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72047272
34* P300_19829295_ChIP-Seq_ESCs_Human1.69255972
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.68649361
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64385390
37ZNF274_21170338_ChIP-Seq_K562_Hela1.61623964
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57421493
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55552353
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.53518725
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53206770
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.51723110
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.49814592
44VDR_22108803_ChIP-Seq_LS180_Human1.49329556
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.47658574
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45730408
47* AR_25329375_ChIP-Seq_VCAP_Human1.45439528
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44963282
49* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44913149
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43822045
51* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43189139
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42933416
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39574180
54FUS_26573619_Chip-Seq_HEK293_Human1.38702740
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.38644232
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36422473
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.34509977
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34289099
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33063118
60RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.30515153
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29929051
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28134935
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.27759129
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27514848
65STAT3_23295773_ChIP-Seq_U87_Human1.27192061
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25199714
67RNF2_27304074_Chip-Seq_NSC_Mouse1.24242160
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23982973
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22901826
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.22860688
71IGF1R_20145208_ChIP-Seq_DFB_Human1.21280522
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.20204902
73TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.19051305
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18961544
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.18251548
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17434120
77AHR_22903824_ChIP-Seq_MCF-7_Human1.15854745
78EWS_26573619_Chip-Seq_HEK293_Human1.15330742
79* AR_19668381_ChIP-Seq_PC3_Human1.15082791
80ER_23166858_ChIP-Seq_MCF-7_Human1.14850034
81* TCF4_23295773_ChIP-Seq_U87_Human1.14255002
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13868281
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12464555
84SOX9_26525672_Chip-Seq_HEART_Mouse1.12427198
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12294754
86RUNX2_22187159_ChIP-Seq_PCA_Human1.12106184
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.10108620
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09409519
89CBP_20019798_ChIP-Seq_JUKART_Human1.09409519
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.08330811
91* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08234977
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07730965
93TP53_16413492_ChIP-PET_HCT116_Human1.06871598
94* KDM2B_26808549_Chip-Seq_REH_Human1.06816170
95GATA1_26923725_Chip-Seq_HPCs_Mouse1.06259046
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05979596
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05501886
98* BCAT_22108803_ChIP-Seq_LS180_Human1.04203757
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04009138
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03652971
101STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03194720
102TP53_18474530_ChIP-ChIP_U2OS_Human1.03011392
103* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02205888
104RXR_22108803_ChIP-Seq_LS180_Human1.01522837
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.01422807
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.01208190
107* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99611765
108TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99420891
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99420891
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97289671
111* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96879738
112WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96375082
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96086094
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93320171
115SMAD3_21741376_ChIP-Seq_HESCs_Human0.92808750
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.92720917
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.92158534
118JUN_21703547_ChIP-Seq_K562_Human0.91950997
119E2F1_18555785_Chip-Seq_ESCs_Mouse0.89040055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.37574035
2MP0003880_abnormal_central_pattern4.74612288
3MP0003635_abnormal_synaptic_transmissio4.01249293
4MP0009046_muscle_twitch3.58998066
5MP0004270_analgesia3.54979493
6MP0009745_abnormal_behavioral_response3.45578301
7MP0002064_seizures3.26572388
8MP0002063_abnormal_learning/memory/cond3.20435082
9MP0001968_abnormal_touch/_nociception3.11495382
10MP0002572_abnormal_emotion/affect_behav2.87194208
11MP0005423_abnormal_somatic_nervous2.76888131
12MP0001486_abnormal_startle_reflex2.68216946
13MP0002734_abnormal_mechanical_nocicepti2.65272008
14MP0002736_abnormal_nociception_after2.60489342
15MP0002272_abnormal_nervous_system2.57206905
16MP0001440_abnormal_grooming_behavior2.45859235
17MP0002067_abnormal_sensory_capabilities2.24583285
18MP0001501_abnormal_sleep_pattern2.24177700
19MP0004043_abnormal_pH_regulation2.18243159
20MP0002735_abnormal_chemical_nociception2.05766032
21MP0000778_abnormal_nervous_system2.02451211
22MP0002733_abnormal_thermal_nociception1.97515597
23MP0004885_abnormal_endolymph1.96603042
24MP0009780_abnormal_chondrocyte_physiolo1.93223644
25MP0003329_amyloid_beta_deposits1.87881431
26MP0001970_abnormal_pain_threshold1.86758802
27MP0002557_abnormal_social/conspecific_i1.84024664
28MP0005386_behavior/neurological_phenoty1.79128595
29MP0004924_abnormal_behavior1.79128595
30MP0002184_abnormal_innervation1.78660007
31MP0008569_lethality_at_weaning1.77878964
32MP0005646_abnormal_pituitary_gland1.60360340
33MP0002638_abnormal_pupillary_reflex1.59876049
34MP0006292_abnormal_olfactory_placode1.58983296
35MP0001984_abnormal_olfaction1.56413314
36MP0003879_abnormal_hair_cell1.55187188
37MP0002822_catalepsy1.54926264
38MP0006276_abnormal_autonomic_nervous1.52175110
39MP0004142_abnormal_muscle_tone1.50490818
40MP0004858_abnormal_nervous_system1.50404949
41MP0002066_abnormal_motor_capabilities/c1.44224639
42MP0000955_abnormal_spinal_cord1.42708031
43MP0004811_abnormal_neuron_physiology1.37405846
44MP0000566_synostosis1.37099326
45MP0003633_abnormal_nervous_system1.36061211
46MP0008877_abnormal_DNA_methylation1.35649515
47MP0002882_abnormal_neuron_morphology1.34755246
48MP0003121_genomic_imprinting1.22249671
49MP0001502_abnormal_circadian_rhythm1.22161425
50MP0004742_abnormal_vestibular_system1.21843596
51MP0002909_abnormal_adrenal_gland1.20649734
52MP0003631_nervous_system_phenotype1.16516959
53MP0002152_abnormal_brain_morphology1.15089833
54MP0001905_abnormal_dopamine_level1.12683102
55MP0001765_abnormal_ion_homeostasis1.11895621
56MP0001188_hyperpigmentation1.07465904
57MP0004215_abnormal_myocardial_fiber1.07271765
58MP0003690_abnormal_glial_cell1.05491240
59MP0001529_abnormal_vocalization1.05065778
60MP0005645_abnormal_hypothalamus_physiol1.04698961
61MP0001963_abnormal_hearing_physiology1.04667903
62MP0003787_abnormal_imprinting1.04031949
63MP0001485_abnormal_pinna_reflex1.02618966
64MP0002234_abnormal_pharynx_morphology0.98791419
65MP0008872_abnormal_physiological_respon0.98021738
66MP0003122_maternal_imprinting0.97351929
67MP0002229_neurodegeneration0.96994293
68MP0002876_abnormal_thyroid_physiology0.96959852
69MP0000751_myopathy0.95087448
70MP0005551_abnormal_eye_electrophysiolog0.93825299
71MP0004147_increased_porphyrin_level0.93731659
72MP0003136_yellow_coat_color0.93648843
73MP0002837_dystrophic_cardiac_calcinosis0.92499917
74MP0002069_abnormal_eating/drinking_beha0.92445401
75MP0004145_abnormal_muscle_electrophysio0.92338245
76MP0010386_abnormal_urinary_bladder0.92203564
77MP0003634_abnormal_glial_cell0.91369125
78MP0001986_abnormal_taste_sensitivity0.91177280
79MP0002653_abnormal_ependyma_morphology0.91120394
80MP0005253_abnormal_eye_physiology0.89679705
81MP0005248_abnormal_Harderian_gland0.89548581
82MP0004484_altered_response_of0.88899685
83MP0003632_abnormal_nervous_system0.87235321
84MP0005535_abnormal_body_temperature0.87058280
85MP0000631_abnormal_neuroendocrine_gland0.86479141
86MP0000569_abnormal_digit_pigmentation0.85590072
87MP0001177_atelectasis0.85009957
88MP0004085_abnormal_heartbeat0.84750456
89MP0004133_heterotaxia0.84607811
90MP0008874_decreased_physiological_sensi0.84065423
91MP0006072_abnormal_retinal_apoptosis0.82435166
92MP0003137_abnormal_impulse_conducting0.82237822
93MP0002102_abnormal_ear_morphology0.80807038
94MP0000604_amyloidosis0.80682036
95MP0003890_abnormal_embryonic-extraembry0.80012548
96MP0005187_abnormal_penis_morphology0.79867346
97MP0002752_abnormal_somatic_nervous0.76788520
98MP0004233_abnormal_muscle_weight0.75019136
99MP0001664_abnormal_digestion0.73314669
100MP0003119_abnormal_digestive_system0.71684522
101MP0003123_paternal_imprinting0.70923660
102MP0000026_abnormal_inner_ear0.70546150
103MP0002751_abnormal_autonomic_nervous0.70225796
104MP0010234_abnormal_vibrissa_follicle0.70210832
105MP0003938_abnormal_ear_development0.69402130
106MP0003646_muscle_fatigue0.68796072
107MP0000920_abnormal_myelination0.66234506
108MP0005195_abnormal_posterior_eye0.64966558
109MP0000013_abnormal_adipose_tissue0.64466839
110MP0001943_abnormal_respiration0.63431615
111MP0005332_abnormal_amino_acid0.63212371
112MP0000049_abnormal_middle_ear0.62556582
113MP0001299_abnormal_eye_distance/0.60560214
114MP0010770_preweaning_lethality0.58926946
115MP0002082_postnatal_lethality0.58926946
116MP0005394_taste/olfaction_phenotype0.57985727
117MP0005499_abnormal_olfactory_system0.57985727
118MP0010769_abnormal_survival0.57316570
119MP0003861_abnormal_nervous_system0.56586418
120MP0002090_abnormal_vision0.56402261
121MP0003283_abnormal_digestive_organ0.56224708
122MP0003075_altered_response_to0.55308065
123MP0005377_hearing/vestibular/ear_phenot0.54220707

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.45612761
2Focal seizures (HP:0007359)5.48860758
3Epileptic encephalopathy (HP:0200134)5.02871912
4Atonic seizures (HP:0010819)4.92069438
5Myokymia (HP:0002411)4.84073639
6Hyperventilation (HP:0002883)4.60887312
7Visual hallucinations (HP:0002367)4.54656032
8Febrile seizures (HP:0002373)4.48227757
9Absence seizures (HP:0002121)4.16445509
10Generalized tonic-clonic seizures (HP:0002069)3.96966071
11Broad-based gait (HP:0002136)3.93099617
12Progressive cerebellar ataxia (HP:0002073)3.88979336
13Dialeptic seizures (HP:0011146)3.84016050
14Limb dystonia (HP:0002451)3.75085141
15Abnormality of binocular vision (HP:0011514)3.58527498
16Diplopia (HP:0000651)3.58527498
17Increased circulating renin level (HP:0000848)3.43813165
18Abnormal eating behavior (HP:0100738)3.30404371
19Hemiparesis (HP:0001269)3.26840673
20Gaze-evoked nystagmus (HP:0000640)3.20277510
21Metabolic alkalosis (HP:0200114)3.20160277
22Drooling (HP:0002307)3.10908120
23Excessive salivation (HP:0003781)3.10908120
24Dysdiadochokinesis (HP:0002075)3.10797099
25Poor eye contact (HP:0000817)3.08460253
26Action tremor (HP:0002345)3.03267592
27Hypomagnesemia (HP:0002917)3.01983938
28Polyphagia (HP:0002591)2.96869407
29Truncal ataxia (HP:0002078)2.96361197
30Impaired social interactions (HP:0000735)2.91340547
31Abnormal social behavior (HP:0012433)2.91340547
32Status epilepticus (HP:0002133)2.90230448
33Impaired vibration sensation in the lower limbs (HP:0002166)2.79345958
34Hemiplegia (HP:0002301)2.77214298
35Supranuclear gaze palsy (HP:0000605)2.67602598
36Cerebral inclusion bodies (HP:0100314)2.67015094
37Amblyopia (HP:0000646)2.65884795
38Dysmetria (HP:0001310)2.65355631
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.64323848
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64323848
41Hypokalemic alkalosis (HP:0001949)2.62650098
42Abnormality of the labia minora (HP:0012880)2.61693325
43Scanning speech (HP:0002168)2.59749389
44Mutism (HP:0002300)2.55627181
45Abnormal urine output (HP:0012590)2.54777246
46Impaired smooth pursuit (HP:0007772)2.54481153
47Epileptiform EEG discharges (HP:0011182)2.54311912
48Postural instability (HP:0002172)2.53146822
49Dysmetric saccades (HP:0000641)2.50674302
50True hermaphroditism (HP:0010459)2.50192122
51Inability to walk (HP:0002540)2.49182993
52Neurofibrillary tangles (HP:0002185)2.48742503
53Anxiety (HP:0000739)2.44721917
54Depression (HP:0000716)2.44476071
55Progressive inability to walk (HP:0002505)2.43299726
56Urinary bladder sphincter dysfunction (HP:0002839)2.41899388
57Polyuria (HP:0000103)2.41018786
58Morphological abnormality of the pyramidal tract (HP:0002062)2.40767715
59Fetal akinesia sequence (HP:0001989)2.38975947
60EEG with generalized epileptiform discharges (HP:0011198)2.38803813
61Urinary urgency (HP:0000012)2.35602495
62Abnormality of magnesium homeostasis (HP:0004921)2.34441333
63Intention tremor (HP:0002080)2.33218810
64Stereotypic behavior (HP:0000733)2.32703196
65Protruding tongue (HP:0010808)2.31520433
66Absent speech (HP:0001344)2.31009481
67Genetic anticipation (HP:0003743)2.30163938
68Abnormality of the corticospinal tract (HP:0002492)2.29741186
69Ankle clonus (HP:0011448)2.29634437
70Abnormality of renal excretion (HP:0011036)2.26463722
71Hypsarrhythmia (HP:0002521)2.22188452
72Bradykinesia (HP:0002067)2.18983902
73Polydipsia (HP:0001959)2.18600337
74Abnormal drinking behavior (HP:0030082)2.18600337
75Spastic tetraplegia (HP:0002510)2.17968043
76Aplasia involving bones of the extremities (HP:0009825)2.16903365
77Aplasia involving bones of the upper limbs (HP:0009823)2.16903365
78Aplasia of the phalanges of the hand (HP:0009802)2.16903365
79Gout (HP:0001997)2.15960074
80Generalized myoclonic seizures (HP:0002123)2.14388657
81Abnormality of ocular smooth pursuit (HP:0000617)2.14327036
82Blue irides (HP:0000635)2.13699498
83Pheochromocytoma (HP:0002666)2.13554306
84Insidious onset (HP:0003587)2.09950089
85Termporal pattern (HP:0011008)2.09950089
86Hepatoblastoma (HP:0002884)2.09415687
87Dyskinesia (HP:0100660)2.06958530
88Spastic gait (HP:0002064)2.06609221
89Megalencephaly (HP:0001355)2.05117154
90Abnormality of the lower motor neuron (HP:0002366)2.05104178
91Split foot (HP:0001839)2.01221747
92Abnormality of salivation (HP:0100755)2.00723820
93Nephronophthisis (HP:0000090)1.99181035
94Hyperactive renin-angiotensin system (HP:0000841)1.98793709
95Sleep apnea (HP:0010535)1.98046915
96Fair hair (HP:0002286)1.98021440
97Akinesia (HP:0002304)1.96634811
98Confusion (HP:0001289)1.95818885
99Gait imbalance (HP:0002141)1.95372406
100Generalized hypopigmentation of hair (HP:0011358)1.95015266
101Lower limb muscle weakness (HP:0007340)1.94533604
102Optic nerve hypoplasia (HP:0000609)1.94492899
103Impaired vibratory sensation (HP:0002495)1.92783888
104Medial flaring of the eyebrow (HP:0010747)1.92703325
105Resting tremor (HP:0002322)1.91693582
106Lissencephaly (HP:0001339)1.89866856
107Neuroendocrine neoplasm (HP:0100634)1.89796903
108Pancreatic fibrosis (HP:0100732)1.89104195
109Amyotrophic lateral sclerosis (HP:0007354)1.88554278
110Clumsiness (HP:0002312)1.88335286
111Genital tract atresia (HP:0001827)1.87611023
112Abnormality of renin-angiotensin system (HP:0000847)1.87574521
113Narrow nasal bridge (HP:0000446)1.86764477
114Papilledema (HP:0001085)1.86322334
115Molar tooth sign on MRI (HP:0002419)1.84651123
116Abnormality of midbrain morphology (HP:0002418)1.84651123
117Hyperaldosteronism (HP:0000859)1.82109009
118Psychosis (HP:0000709)1.80820681
119Torticollis (HP:0000473)1.80806276
120Vaginal atresia (HP:0000148)1.80521614
121Congenital primary aphakia (HP:0007707)1.80520467
122Agitation (HP:0000713)1.79324326
123Specific learning disability (HP:0001328)1.78859666
124Gait ataxia (HP:0002066)1.78822771
125Cutaneous finger syndactyly (HP:0010554)1.75737013
126Hypoplasia of the corpus callosum (HP:0002079)1.73250063
127Poor suck (HP:0002033)1.72522602
128Gastroesophageal reflux (HP:0002020)1.70140992
129Retinal dysplasia (HP:0007973)1.68399348
130Nephrogenic diabetes insipidus (HP:0009806)1.65910896
131Pachygyria (HP:0001302)1.65351653
132Pancreatic cysts (HP:0001737)1.64744557
133Bronchomalacia (HP:0002780)1.63491527
134Tented upper lip vermilion (HP:0010804)1.62087513
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.62026244
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.61185031
137Intellectual disability, severe (HP:0010864)1.61070131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.80260693
2EPHA43.62140649
3MARK13.57193861
4CASK3.52927667
5MAP3K43.35893156
6MAP3K93.15436567
7MAP2K72.91345434
8OXSR12.57678564
9MINK12.27212716
10MAP3K122.21245033
11NTRK22.17467099
12DAPK22.12319200
13TNIK2.05748916
14RIPK42.05558591
15MAP2K42.03260135
16WNK32.03081654
17CDK191.85032026
18PNCK1.81156250
19AKT31.62961819
20PAK61.60435190
21DAPK11.58015425
22PLK21.57224652
23MAPK131.55716468
24WNK41.49787047
25KSR11.39464451
26NTRK11.35355364
27DYRK21.31592267
28CDK51.31467128
29CAMKK21.29295065
30KSR21.26221884
31GRK51.24672217
32CAMKK11.23619800
33PRKCG1.21831981
34STK391.13051774
35SGK2231.12300424
36SGK4941.12300424
37PHKG21.12056717
38PHKG11.12056717
39MAP4K21.12026271
40SIK21.10498171
41SGK21.08377457
42CAMK2A1.04424579
43STK381.02351360
44BCR1.02192381
45CSNK1G10.96325430
46PRPF4B0.95531110
47CSNK1G30.92760917
48CAMK2B0.85699395
49FES0.85201354
50PDK40.84098986
51PDK30.84098986
52CSNK1A1L0.82124924
53MKNK20.80522127
54SGK30.79670564
55LATS20.79615702
56FRK0.77850398
57BMPR20.77688155
58SGK10.77510024
59STK110.77289817
60DYRK1A0.77156711
61TRIM280.76996859
62FGR0.75780687
63MAP3K20.75572825
64UHMK10.75517680
65CDK180.75492010
66SCYL20.75252885
67PAK30.74905029
68BMPR1B0.74810180
69ARAF0.74200562
70CDK150.73673197
71CSNK1G20.73395853
72PRKD30.73364301
73CCNB10.72181669
74PTK2B0.70969678
75CDK140.70368768
76EPHA30.70163271
77ERBB30.69514392
78MAP3K130.69051886
79WNK10.68344447
80PRKCE0.68330338
81TYRO30.66950199
82MAP3K60.66771880
83CAMK40.64763233
84MAPK120.63844055
85NME10.63088126
86CDK11A0.61057626
87MAPKAPK50.58004079
88CAMK10.57277866
89ADRBK20.55925486
90PDK20.55574156
91PDPK10.53192557
92ADRBK10.53150158
93RET0.50711445
94PDK10.50155987
95CSNK1D0.49589427
96PRKG10.48490904
97CSNK1A10.47459022
98TSSK60.47196103
99ROCK20.46173927
100MAPK150.45701434
101CAMK2G0.45392780
102PRKCZ0.45287629
103CAMK2D0.44617314
104FGFR20.44154874
105CDK30.44118081
106EPHB20.43228063
107CAMK1G0.43146140
108RPS6KA30.42785717
109PKN10.42057588
110LMTK20.41888770
111PRKCH0.41794967
112INSRR0.41705760
113RAF10.41489352
114MARK20.40492051
115FER0.40195643
116NEK60.39889926
117MAPK100.39682726
118CSNK1E0.39550711
119TNK20.39173166
120FYN0.38494776
121STK38L0.37203871
122PINK10.35213620
123PRKCA0.33370966
124GRK70.32809576
125PRKACA0.32236818
126PRKDC0.32086711
127PRKACB0.31562571
128ROCK10.31380573
129PRKCB0.31155573
130ERBB20.29858173

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.15600674
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32437375
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.72742762
4GABAergic synapse_Homo sapiens_hsa047272.67952095
5Glutamatergic synapse_Homo sapiens_hsa047242.54100829
6Long-term potentiation_Homo sapiens_hsa047202.50127753
7Collecting duct acid secretion_Homo sapiens_hsa049662.49235979
8Morphine addiction_Homo sapiens_hsa050322.42471691
9Circadian entrainment_Homo sapiens_hsa047132.37095371
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.32166657
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24870185
12Amphetamine addiction_Homo sapiens_hsa050312.21639460
13Olfactory transduction_Homo sapiens_hsa047402.16764895
14Salivary secretion_Homo sapiens_hsa049702.16514847
15Gastric acid secretion_Homo sapiens_hsa049711.98710638
16Taste transduction_Homo sapiens_hsa047421.90270903
17Dopaminergic synapse_Homo sapiens_hsa047281.88805971
18Insulin secretion_Homo sapiens_hsa049111.78572792
19Renin secretion_Homo sapiens_hsa049241.75068888
20Long-term depression_Homo sapiens_hsa047301.68715430
21Serotonergic synapse_Homo sapiens_hsa047261.62393775
22Cholinergic synapse_Homo sapiens_hsa047251.45725876
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44924890
24Calcium signaling pathway_Homo sapiens_hsa040201.44503636
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44057968
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38639362
27Oxytocin signaling pathway_Homo sapiens_hsa049211.38336691
28Cocaine addiction_Homo sapiens_hsa050301.38241385
29Vibrio cholerae infection_Homo sapiens_hsa051101.29963329
30Gap junction_Homo sapiens_hsa045401.22557305
31Nitrogen metabolism_Homo sapiens_hsa009101.21727067
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17762874
33Cardiac muscle contraction_Homo sapiens_hsa042601.15172991
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15054576
35cAMP signaling pathway_Homo sapiens_hsa040241.12815674
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12175511
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11585138
38GnRH signaling pathway_Homo sapiens_hsa049121.10824400
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07680991
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07385102
41Axon guidance_Homo sapiens_hsa043601.00073963
42Estrogen signaling pathway_Homo sapiens_hsa049150.98937750
43Oxidative phosphorylation_Homo sapiens_hsa001900.98149169
44Vitamin B6 metabolism_Homo sapiens_hsa007500.97379307
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95819094
46Thyroid hormone synthesis_Homo sapiens_hsa049180.94580085
47ErbB signaling pathway_Homo sapiens_hsa040120.92879690
48Butanoate metabolism_Homo sapiens_hsa006500.91555994
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90608631
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87084437
51Pancreatic secretion_Homo sapiens_hsa049720.85787130
52Melanogenesis_Homo sapiens_hsa049160.84739843
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83974175
54Glioma_Homo sapiens_hsa052140.83700431
55Dorso-ventral axis formation_Homo sapiens_hsa043200.82844000
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81870298
57Type II diabetes mellitus_Homo sapiens_hsa049300.80880860
58Bile secretion_Homo sapiens_hsa049760.80745215
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79784056
60Alzheimers disease_Homo sapiens_hsa050100.77991971
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73569765
62Fatty acid biosynthesis_Homo sapiens_hsa000610.73288394
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.73081477
64Choline metabolism in cancer_Homo sapiens_hsa052310.71734136
65Steroid biosynthesis_Homo sapiens_hsa001000.63480451
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.62534745
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60032465
68* Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.58753669
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58216830
70Hippo signaling pathway_Homo sapiens_hsa043900.57709578
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57656608
72Phototransduction_Homo sapiens_hsa047440.57490598
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56870120
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55476554
75Oocyte meiosis_Homo sapiens_hsa041140.54092487
76Ether lipid metabolism_Homo sapiens_hsa005650.53401896
77Dilated cardiomyopathy_Homo sapiens_hsa054140.52789190
78MAPK signaling pathway_Homo sapiens_hsa040100.51354990
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50914003
80Glucagon signaling pathway_Homo sapiens_hsa049220.49609106
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49112975
82Propanoate metabolism_Homo sapiens_hsa006400.49008862
83Mineral absorption_Homo sapiens_hsa049780.48039588
84Inositol phosphate metabolism_Homo sapiens_hsa005620.47930247
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46307274
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45958223
87Parkinsons disease_Homo sapiens_hsa050120.45560012
88Circadian rhythm_Homo sapiens_hsa047100.42232074
89Ras signaling pathway_Homo sapiens_hsa040140.41417748
90Arginine biosynthesis_Homo sapiens_hsa002200.38887883
91Rap1 signaling pathway_Homo sapiens_hsa040150.38674013
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37601216
93Rheumatoid arthritis_Homo sapiens_hsa053230.37586048
94beta-Alanine metabolism_Homo sapiens_hsa004100.37473963
95Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37288257
96Linoleic acid metabolism_Homo sapiens_hsa005910.36953686
97Pyruvate metabolism_Homo sapiens_hsa006200.36783517
98Wnt signaling pathway_Homo sapiens_hsa043100.34387630
99Ovarian steroidogenesis_Homo sapiens_hsa049130.33971174
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.33746438
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33679229
102Type I diabetes mellitus_Homo sapiens_hsa049400.31778219
103Endometrial cancer_Homo sapiens_hsa052130.31431664
104Tight junction_Homo sapiens_hsa045300.30097131
105Regulation of autophagy_Homo sapiens_hsa041400.29166389
106mTOR signaling pathway_Homo sapiens_hsa041500.29004483
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28456297
108African trypanosomiasis_Homo sapiens_hsa051430.28184157
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.28059668
110Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27860198
111Basal cell carcinoma_Homo sapiens_hsa052170.27465418
112Fatty acid metabolism_Homo sapiens_hsa012120.26871872
113Alcoholism_Homo sapiens_hsa050340.26504225
114Huntingtons disease_Homo sapiens_hsa050160.26130324
115Histidine metabolism_Homo sapiens_hsa003400.24252710
116VEGF signaling pathway_Homo sapiens_hsa043700.24058797
117Renal cell carcinoma_Homo sapiens_hsa052110.22244867
118Hedgehog signaling pathway_Homo sapiens_hsa043400.20822657

Most similar genes based on co-expression Upload to Enrichr

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