FUT4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)6.47230359
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.73542175
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.73542175
4UDP-N-acetylglucosamine metabolic process (GO:0006047)5.63641144
5antigen processing and presentation of endogenous antigen (GO:0019883)5.41757269
6glucosamine-containing compound catabolic process (GO:1901072)5.13715880
7maintenance of gastrointestinal epithelium (GO:0030277)5.11917880
8hepatocyte apoptotic process (GO:0097284)4.93560288
9negative regulation of erythrocyte differentiation (GO:0045647)4.71109365
10response to muramyl dipeptide (GO:0032495)4.46004045
11neutrophil mediated immunity (GO:0002446)4.44478939
12cellular extravasation (GO:0045123)4.38406774
13NIK/NF-kappaB signaling (GO:0038061)4.24861250
14negative regulation of growth of symbiont in host (GO:0044130)4.20309216
15negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.20309216
16modulation of growth of symbiont involved in interaction with host (GO:0044144)4.20309216
17regulation of growth of symbiont in host (GO:0044126)4.20309216
18negative regulation of interleukin-8 production (GO:0032717)4.17738718
19antigen processing and presentation via MHC class Ib (GO:0002475)4.15201181
20cellular response to zinc ion (GO:0071294)4.05886541
21innate immune response in mucosa (GO:0002227)3.98852499
22Arp2/3 complex-mediated actin nucleation (GO:0034314)3.97765868
23establishment of endothelial barrier (GO:0061028)3.93681331
24Golgi transport vesicle coating (GO:0048200)3.91399802
25COPI coating of Golgi vesicle (GO:0048205)3.91399802
26regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.90199237
27leukocyte mediated cytotoxicity (GO:0001909)3.87645185
28negative regulation of interleukin-12 production (GO:0032695)3.85234425
29mannose metabolic process (GO:0006013)3.80846770
30epithelial structure maintenance (GO:0010669)3.80319771
31detection of other organism (GO:0098543)3.75772928
32regulation of mast cell degranulation (GO:0043304)3.75627940
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.68430057
34regulation of leukocyte degranulation (GO:0043300)3.64032252
35corticosteroid receptor signaling pathway (GO:0031958)3.63408867
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.55540064
37necroptotic process (GO:0070266)3.51354726
38respiratory burst (GO:0045730)3.49090167
39detection of bacterium (GO:0016045)3.47758319
40regulation of vitamin D biosynthetic process (GO:0060556)3.45643287
41regulation of mast cell activation involved in immune response (GO:0033006)3.45101985
42organ or tissue specific immune response (GO:0002251)3.44997073
43antibacterial humoral response (GO:0019731)3.44806003
44negative regulation of phagocytosis (GO:0050765)3.42649822
45regulation of interleukin-8 biosynthetic process (GO:0045414)3.41002627
46myeloid leukocyte mediated immunity (GO:0002444)3.39629768
47antimicrobial humoral response (GO:0019730)3.38980465
48macrophage activation involved in immune response (GO:0002281)3.38824928
49negative regulation of interleukin-6 production (GO:0032715)3.38580022
50mucosal immune response (GO:0002385)3.37681403
51glucocorticoid receptor signaling pathway (GO:0042921)3.34403047
52actin nucleation (GO:0045010)3.32864777
53disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.30789962
54killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.30789962
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30731952
56myeloid cell activation involved in immune response (GO:0002275)3.30147282
57O-glycan processing (GO:0016266)3.29624343
58positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.24683916
59megakaryocyte development (GO:0035855)3.23624015
60sequestering of metal ion (GO:0051238)3.22658305
61response to protozoan (GO:0001562)3.21846949
62lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18298687
63intestinal absorption (GO:0050892)3.18004643
64regulation of mast cell activation (GO:0033003)3.17473134
65regulation of B cell differentiation (GO:0045577)3.16589403
66B cell receptor signaling pathway (GO:0050853)3.16319445
67T cell migration (GO:0072678)3.10723611
68germinal center formation (GO:0002467)3.10292587
69response to host immune response (GO:0052572)3.08674003
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.08674003
71leukocyte degranulation (GO:0043299)3.08218302
72defense response to fungus (GO:0050832)3.08061057
73peptide catabolic process (GO:0043171)3.07360358
74cell wall macromolecule catabolic process (GO:0016998)3.05634769
75neutrophil activation involved in immune response (GO:0002283)3.05556909
76angiotensin maturation (GO:0002003)3.04223005
77response to fungus (GO:0009620)3.03914856
78surfactant homeostasis (GO:0043129)3.03049161
79chaperone mediated protein folding requiring cofactor (GO:0051085)3.02879405
80regulation of regulated secretory pathway (GO:1903305)2.98108678
81leukocyte aggregation (GO:0070486)2.97256713
82regulation of vitamin metabolic process (GO:0030656)2.96419200
83defense response to Gram-positive bacterium (GO:0050830)2.96359678
84amino sugar catabolic process (GO:0046348)2.95198461
85regulation of necroptotic process (GO:0060544)2.93419700
86neutrophil activation (GO:0042119)2.91967480
87regulation of interleukin-12 biosynthetic process (GO:0045075)2.91781657
88mature B cell differentiation involved in immune response (GO:0002313)2.91274941
89regulation of RIG-I signaling pathway (GO:0039535)2.91171871
90positive regulation of mast cell activation (GO:0033005)2.90804617
91definitive hemopoiesis (GO:0060216)2.90361222
92negative regulation of T cell mediated immunity (GO:0002710)2.89855798
93positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.89588422
94regulation of toll-like receptor signaling pathway (GO:0034121)2.89332040
95positive regulation of mast cell degranulation (GO:0043306)2.88651417
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.88651417
97embryonic process involved in female pregnancy (GO:0060136)2.88211806
98lipid translocation (GO:0034204)2.88005799
99phospholipid translocation (GO:0045332)2.88005799
100histone H3-K36 demethylation (GO:0070544)2.87666962
101killing of cells of other organism (GO:0031640)2.87003099
102disruption of cells of other organism (GO:0044364)2.87003099
103myeloid dendritic cell activation (GO:0001773)2.85021326
104defense response to protozoan (GO:0042832)2.82126300
105regulation of interferon-alpha production (GO:0032647)2.81229835
106detection of external biotic stimulus (GO:0098581)2.79418413
107macrophage activation (GO:0042116)2.79070322
108positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.78621351
109detection of biotic stimulus (GO:0009595)2.77250649
110positive regulation of interferon-alpha production (GO:0032727)2.76753493
111positive regulation of granulocyte differentiation (GO:0030854)2.76630865
112microglial cell activation (GO:0001774)2.76456227
113positive regulation of macrophage differentiation (GO:0045651)2.75871070
114regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.75786598
115response to host (GO:0075136)2.75550961
116response to host defenses (GO:0052200)2.75550961
117response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75550961
118myeloid dendritic cell differentiation (GO:0043011)2.74820180
119positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74752982
120immunoglobulin mediated immune response (GO:0016064)2.72557013
121positive regulation of toll-like receptor signaling pathway (GO:0034123)2.72221281
122negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.71853200
123positive regulation of B cell differentiation (GO:0045579)2.71677455
124regulation of tumor necrosis factor production (GO:0032680)2.71005553
125positive regulation of interferon-beta production (GO:0032728)2.69898209
126cell killing (GO:0001906)2.66717585
127endothelial cell development (GO:0001885)2.66547753
128protein maturation by protein folding (GO:0022417)2.65326336
129negative regulation of granulocyte differentiation (GO:0030853)2.62827217
130dendritic cell differentiation (GO:0097028)2.62286630
131regulation of B cell receptor signaling pathway (GO:0050855)2.62058347
132macrophage differentiation (GO:0030225)2.60682277
133pinocytosis (GO:0006907)2.59394124
134positive regulation of gamma-delta T cell activation (GO:0046645)2.58589754
135digestive system process (GO:0022600)2.58073616
136regulation of cellular extravasation (GO:0002691)2.55717811
137positive regulation of lamellipodium assembly (GO:0010592)2.54781624
138regulation of gamma-delta T cell differentiation (GO:0045586)2.53588835
139granulocyte activation (GO:0036230)2.52991028
140regulation of interferon-beta biosynthetic process (GO:0045357)2.52278486
141pentose-phosphate shunt (GO:0006098)2.51636933
142growth hormone receptor signaling pathway (GO:0060396)2.51281890
143angiogenesis involved in wound healing (GO:0060055)2.49478013
144intestinal epithelial cell development (GO:0060576)2.47611127
145dendritic cell migration (GO:0036336)2.47594100
146peptidyl-asparagine modification (GO:0018196)2.45707601
147leukotriene metabolic process (GO:0006691)2.45279256
148mature B cell differentiation (GO:0002335)2.45243081
149programmed necrotic cell death (GO:0097300)2.44193131
150protein N-linked glycosylation via asparagine (GO:0018279)2.43725080
151NADPH regeneration (GO:0006740)2.41580038
152actin filament depolymerization (GO:0030042)2.40911900
153leukocyte cell-cell adhesion (GO:0007159)2.40895999
154modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.40387180
155positive regulation by organism of defense response of other organism involved in symbiotic interact2.40387180
156modulation by symbiont of host immune response (GO:0052553)2.40387180
157positive regulation by symbiont of host defense response (GO:0052509)2.40387180
158modulation by symbiont of host defense response (GO:0052031)2.40387180
159modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.40387180
160negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.40084775
161production of molecular mediator involved in inflammatory response (GO:0002532)2.39645049
162positive regulation of antigen processing and presentation (GO:0002579)2.37447485
1633-UTR-mediated mRNA stabilization (GO:0070935)2.35810537
164JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.34636567
165regulation of gamma-delta T cell activation (GO:0046643)2.33223750
166natural killer cell mediated immunity (GO:0002228)2.32919457
167natural killer cell mediated cytotoxicity (GO:0042267)2.32919457
168regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.32557472
169positive regulation of lamellipodium organization (GO:1902745)2.32102965
170cytokine secretion (GO:0050663)2.31525628

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.47151869
2EGR1_19374776_ChIP-ChIP_THP-1_Human5.12745268
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.60038137
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.41959325
5MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17920082
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.09937075
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96091269
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.92961535
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.80187908
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.78193912
11VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.70272199
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65360052
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.56226359
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.50672685
15GATA1_22025678_ChIP-Seq_K562_Human2.47771561
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.42637192
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.41291495
18* VDR_21846776_ChIP-Seq_THP-1_Human2.40111648
19SCL_19346495_ChIP-Seq_HPC-7_Human2.31982768
20MYC_22102868_ChIP-Seq_BL_Human2.26295673
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22680966
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22274116
23* VDR_24763502_ChIP-Seq_THP-1_Human2.21718791
24TP63_17297297_ChIP-ChIP_HaCaT_Human2.12755729
25* MYB_26560356_Chip-Seq_TH2_Human2.08608197
26SPI1_23547873_ChIP-Seq_NB4_Human2.00025809
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.99149716
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93618495
29MAF_26560356_Chip-Seq_TH1_Human1.91464225
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87902286
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84725896
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84059529
33TCF7_22412390_ChIP-Seq_EML_Mouse1.81666780
34MYB_26560356_Chip-Seq_TH1_Human1.80879381
35SPI1_23127762_ChIP-Seq_K562_Human1.79070459
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76369332
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73348685
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72962617
39* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71180903
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.68182551
41UTX_26944678_Chip-Seq_JUKART_Human1.67931379
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62572644
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61601866
44* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59219456
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.55142791
46GATA6_25053715_ChIP-Seq_YYC3_Human1.52403345
47* GATA4_25053715_ChIP-Seq_YYC3_Human1.52058268
48MAF_26560356_Chip-Seq_TH2_Human1.51272935
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46088504
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.43084664
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.41417586
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.40699389
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39315569
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.37147972
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36580486
56KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36512846
57KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36512846
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36512846
59FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35944255
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35595720
61GATA1_19941826_ChIP-Seq_K562_Human1.35526642
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.35354558
63RUNX_20019798_ChIP-Seq_JUKART_Human1.35204203
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34682459
65SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34670892
66* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.33871736
67GATA3_27048872_Chip-Seq_THYMUS_Human1.33676767
68CLOCK_20551151_ChIP-Seq_293T_Human1.33258364
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32426657
70PU_27001747_Chip-Seq_BMDM_Mouse1.30871308
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29033639
72* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26756346
73NCOR1_26117541_ChIP-Seq_K562_Human1.26745416
74SOX2_20726797_ChIP-Seq_SW620_Human1.25827557
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25511955
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24916099
77SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24332626
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23495966
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.23135764
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18926651
81AR_21909140_ChIP-Seq_LNCAP_Human1.18440580
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16590557
83* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15077343
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13765823
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.12852494
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10825060
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10426660
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10172707
89KDM2B_26808549_Chip-Seq_DND41_Human1.09883507
90TFEB_21752829_ChIP-Seq_HELA_Human1.09868409
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.09661956
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08252705
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08076363
94VDR_24787735_ChIP-Seq_THP-1_Human1.07442085
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06906733
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05885453
97LXR_22292898_ChIP-Seq_THP-1_Human1.05611264
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03913556
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03558227
100* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03506214
101CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02989605
102RUNX1_27514584_Chip-Seq_MCF-7_Human1.01327581
103CIITA_25753668_ChIP-Seq_RAJI_Human1.01205030
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.01124801
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00978301
106GATA2_19941826_ChIP-Seq_K562_Human0.99461330
107KDM2B_26808549_Chip-Seq_JURKAT_Human0.99381056
108RACK7_27058665_Chip-Seq_MCF-7_Human0.98937544
109GATA3_26560356_Chip-Seq_TH2_Human0.97324284
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97054875
111NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97011583
112GATA1_19941827_ChIP-Seq_MEL_Mouse0.96828701
113E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96081954
114SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95839746
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95621298
116* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95253829
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94901092
118ELF5_23300383_ChIP-Seq_T47D_Human0.93947297
119KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93450226
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93122505
121MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91465084
122CHD1_26751641_Chip-Seq_LNCaP_Human0.91143826
123* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90845487
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.89823810
125HOXB4_20404135_ChIP-ChIP_EML_Mouse0.87476503
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86934598
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86934598
128E2F1_21310950_ChIP-Seq_MCF-7_Human0.86796337
129PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86301751
130ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85729846
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82359487
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78925577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage4.01873912
2MP0001873_stomach_inflammation3.18471580
3MP0004264_abnormal_extraembryonic_tissu3.18434972
4MP0003300_gastrointestinal_ulcer2.93029794
5MP0010234_abnormal_vibrissa_follicle2.84358648
6MP0008004_abnormal_stomach_pH2.71949997
7MP0003183_abnormal_peptide_metabolism2.62875039
8MP0001835_abnormal_antigen_presentation2.38533681
9MP0003303_peritoneal_inflammation2.33888785
10MP0010155_abnormal_intestine_physiology2.29532982
11MP0005076_abnormal_cell_differentiation2.23750966
12MP0003436_decreased_susceptibility_to2.21730342
13MP0006082_CNS_inflammation2.20083811
14MP0010352_gastrointestinal_tract_polyps2.12411597
15MP0000685_abnormal_immune_system2.09212958
16MP0003866_abnormal_defecation2.03969065
17MP0002396_abnormal_hematopoietic_system1.99147349
18MP0000490_abnormal_crypts_of1.97479268
19MP0002254_reproductive_system_inflammat1.95762633
20MP0002166_altered_tumor_susceptibility1.95447841
21MP0003566_abnormal_cell_adhesion1.92395865
22MP0000569_abnormal_digit_pigmentation1.84249465
23* MP0002419_abnormal_innate_immunity1.83414145
24MP0009785_altered_susceptibility_to1.81680175
25MP0001666_abnormal_nutrient_absorption1.80172132
26* MP0005025_abnormal_response_to1.72927912
27MP0002452_abnormal_antigen_presenting1.71098699
28MP0002138_abnormal_hepatobiliary_system1.69986844
29MP0001663_abnormal_digestive_system1.68625474
30MP0001853_heart_inflammation1.67421076
31MP0000465_gastrointestinal_hemorrhage1.65865016
32MP0004782_abnormal_surfactant_physiolog1.63833279
33MP0002877_abnormal_melanocyte_morpholog1.63550172
34MP0001800_abnormal_humoral_immune1.62239586
35MP0005451_abnormal_body_composition1.60892309
36MP0003724_increased_susceptibility_to1.57236880
37* MP0001819_abnormal_immune_cell1.55124842
38MP0005387_immune_system_phenotype1.54502703
39MP0001790_abnormal_immune_system1.54502703
40* MP0002420_abnormal_adaptive_immunity1.53901794
41MP0005464_abnormal_platelet_physiology1.52385368
42MP0004808_abnormal_hematopoietic_stem1.51955342
43MP0002998_abnormal_bone_remodeling1.50950683
44MP0004947_skin_inflammation1.50196273
45MP0001533_abnormal_skeleton_physiology1.49890741
46* MP0002148_abnormal_hypersensitivity_rea1.48518440
47MP0002006_tumorigenesis1.48292243
48MP0003656_abnormal_erythrocyte_physiolo1.45322662
49MP0005058_abnormal_lysosome_morphology1.44294038
50MP0002723_abnormal_immune_serum1.42555569
51MP0002405_respiratory_system_inflammati1.40557034
52MP0005381_digestive/alimentary_phenotyp1.39674931
53MP0001845_abnormal_inflammatory_respons1.38206019
54MP0005000_abnormal_immune_tolerance1.38170902
55MP0000477_abnormal_intestine_morphology1.34914979
56MP0005310_abnormal_salivary_gland1.34539595
57MP0005174_abnormal_tail_pigmentation1.33360661
58* MP0002398_abnormal_bone_marrow1.32630060
59MP0004185_abnormal_adipocyte_glucose1.25364018
60* MP0000716_abnormal_immune_system1.25082455
61MP0001664_abnormal_digestion1.25074132
62MP0000462_abnormal_digestive_system1.24957557
63MP0000858_altered_metastatic_potential1.22384271
64MP0001958_emphysema1.19111518
65MP0003705_abnormal_hypodermis_morpholog1.18325133
66MP0003172_abnormal_lysosome_physiology1.17856817
67MP0008260_abnormal_autophagy1.16985338
68MP0005397_hematopoietic_system_phenotyp1.16267814
69MP0001545_abnormal_hematopoietic_system1.16267814
70MP0009840_abnormal_foam_cell1.15674292
71MP0003075_altered_response_to1.15254491
72MP0010678_abnormal_skin_adnexa1.13685947
73MP0010307_abnormal_tumor_latency1.12435684
74* MP0002429_abnormal_blood_cell1.11668956
75MP0002009_preneoplasia1.11316991
76MP0001881_abnormal_mammary_gland1.10812156
77MP0005671_abnormal_response_to1.09463227
78MP0000015_abnormal_ear_pigmentation1.07098792
79* MP0002722_abnormal_immune_system1.05801219
80MP0000689_abnormal_spleen_morphology1.01522608
81MP0005167_abnormal_blood-brain_barrier1.01386944
82MP0005166_decreased_susceptibility_to1.01151526
83MP0000537_abnormal_urethra_morphology1.00727436
84MP0001765_abnormal_ion_homeostasis0.95648164
85MP0002132_abnormal_respiratory_system0.94344636
86MP0003693_abnormal_embryo_hatching0.94331476
87MP0003091_abnormal_cell_migration0.92028254
88MP0004510_myositis0.91185668
89MP0008469_abnormal_protein_level0.90970447
90MP0003943_abnormal_hepatobiliary_system0.88384579
91MP0000470_abnormal_stomach_morphology0.88145751
92MP0003448_altered_tumor_morphology0.86341655
93MP0005164_abnormal_response_to0.85852807
94MP0001851_eye_inflammation0.85839301
95MP0009278_abnormal_bone_marrow0.84308623
96MP0003763_abnormal_thymus_physiology0.83460858
97MP0001879_abnormal_lymphatic_vessel0.82682248
98MP0003221_abnormal_cardiomyocyte_apopto0.82604664
99MP0002933_joint_inflammation0.82492507
100MP0005666_abnormal_adipose_tissue0.82331670
101MP0000383_abnormal_hair_follicle0.81440166
102MP0002019_abnormal_tumor_incidence0.81234808
103MP0003191_abnormal_cellular_cholesterol0.80314862
104MP0000343_altered_response_to0.80053527
105MP0009765_abnormal_xenobiotic_induced0.78543694
106MP0008057_abnormal_DNA_replication0.78415866
107MP0009115_abnormal_fat_cell0.76464742
108MP0009333_abnormal_splenocyte_physiolog0.75549686
109MP0003453_abnormal_keratinocyte_physiol0.74433639
110MP0004883_abnormal_blood_vessel0.73956334
111MP0003111_abnormal_nucleus_morphology0.73461375
112MP0005390_skeleton_phenotype0.73397439
113MP0000249_abnormal_blood_vessel0.73146423
114MP0009764_decreased_sensitivity_to0.73003723
115MP0000604_amyloidosis0.72876496
116MP0009763_increased_sensitivity_to0.69875347
117MP0003828_pulmonary_edema0.68580227
118MP0000703_abnormal_thymus_morphology0.68393816
119MP0005023_abnormal_wound_healing0.67862944
120MP0005075_abnormal_melanosome_morpholog0.66706687
121MP0009931_abnormal_skin_appearance0.65936866
122MP0005647_abnormal_sex_gland0.65860850
123MP0003795_abnormal_bone_structure0.65360371
124MP0005319_abnormal_enzyme/_coenzyme0.64232920

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)4.27306545
2Thrombocytosis (HP:0001894)4.12745172
3Recurrent abscess formation (HP:0002722)4.09041049
4Stomatitis (HP:0010280)4.06145644
5Recurrent cutaneous fungal infections (HP:0011370)3.96942251
6Chronic mucocutaneous candidiasis (HP:0002728)3.96942251
7Recurrent bacterial skin infections (HP:0005406)3.77400771
8Acute lymphatic leukemia (HP:0006721)3.75992495
9Eczematoid dermatitis (HP:0000976)3.71479800
10Periodontitis (HP:0000704)3.65895131
11Chronic otitis media (HP:0000389)3.55963902
12Increased cerebral lipofuscin (HP:0011813)3.54561243
13Abnormality of B cell number (HP:0010975)3.42858353
14B lymphocytopenia (HP:0010976)3.39191206
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.37172056
16Abnormality of glycolipid metabolism (HP:0010969)3.28805298
17Abnormality of liposaccharide metabolism (HP:0010968)3.28805298
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.28805298
19Amyloidosis (HP:0011034)3.25236434
20Recurrent viral infections (HP:0004429)3.23812216
21Recurrent fungal infections (HP:0002841)3.19120761
22Granulocytopenia (HP:0001913)3.16737176
23Myositis (HP:0100614)3.12483358
24Retrobulbar optic neuritis (HP:0100654)3.06651944
25Optic neuritis (HP:0100653)3.06651944
26Cortical dysplasia (HP:0002539)3.05009084
27Fatigue (HP:0012378)2.88678938
28Spondylolisthesis (HP:0003302)2.86401318
29Abnormality of the fingertips (HP:0001211)2.83887605
30Thoracic kyphosis (HP:0002942)2.82723897
31Panhypogammaglobulinemia (HP:0003139)2.75569776
32Leukocytosis (HP:0001974)2.75328845
33Ileus (HP:0002595)2.75293568
34Neoplasm of head and neck (HP:0012288)2.75104160
35Esophageal neoplasm (HP:0100751)2.75104160
36Abnormality of macrophages (HP:0004311)2.74339921
37Elevated erythrocyte sedimentation rate (HP:0003565)2.71335844
38IgM deficiency (HP:0002850)2.70506983
39Autoimmune thrombocytopenia (HP:0001973)2.70287929
40Right ventricular cardiomyopathy (HP:0011663)2.70160918
41Chronic diarrhea (HP:0002028)2.68881354
42Chest pain (HP:0100749)2.68377255
43Gastrointestinal inflammation (HP:0004386)2.67887187
44Rectal prolapse (HP:0002035)2.67423730
45Colitis (HP:0002583)2.63774418
46Hematochezia (HP:0002573)2.61331584
47Inflammation of the large intestine (HP:0002037)2.59288438
48Prolonged bleeding time (HP:0003010)2.57122230
49Gastrointestinal stroma tumor (HP:0100723)2.55990439
50Encephalitis (HP:0002383)2.55210966
51Aortic aneurysm (HP:0004942)2.54744130
52Conjunctival hamartoma (HP:0100780)2.53867293
53Hemoptysis (HP:0002105)2.50266104
54Agammaglobulinemia (HP:0004432)2.47687231
55Vacuolated lymphocytes (HP:0001922)2.47671494
56Arterial thrombosis (HP:0004420)2.44074227
57Pustule (HP:0200039)2.38689944
58Abdominal distention (HP:0003270)2.38433067
59Abnormality of the lumbar spine (HP:0100712)2.35889041
60Abnormality of the columella (HP:0009929)2.35381477
61Impaired platelet aggregation (HP:0003540)2.35305402
62Abnormal platelet function (HP:0011869)2.35305402
63Eosinophilia (HP:0001880)2.35301016
64Increased IgE level (HP:0003212)2.34788560
65Keratoconjunctivitis sicca (HP:0001097)2.32216007
66Increased serum ferritin (HP:0003281)2.31319976
67Orchitis (HP:0100796)2.29978993
68Epistaxis (HP:0000421)2.29841423
69Petechiae (HP:0000967)2.29295143
70Spontaneous hematomas (HP:0007420)2.28998850
71Recurrent skin infections (HP:0001581)2.27552845
72Loss of speech (HP:0002371)2.26518618
73Abnormality of the prostate (HP:0008775)2.25948622
74Gingivitis (HP:0000230)2.25808758
75Cellulitis (HP:0100658)2.23814879
76Gastrointestinal infarctions (HP:0005244)2.22911971
77Abnormality of iron homeostasis (HP:0011031)2.20582733
78Abnormality of T cells (HP:0002843)2.19610679
79Neoplasm of the rectum (HP:0100743)2.18298433
80Reduced antithrombin III activity (HP:0001976)2.14632385
81Hepatosplenomegaly (HP:0001433)2.14248077
82Abnormality of the thoracic spine (HP:0100711)2.13677536
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13593202
84Mediastinal lymphadenopathy (HP:0100721)2.13499138
85Abnormal foot bone ossification (HP:0010675)2.13369365
86Keratoconjunctivitis (HP:0001096)2.12823546
87Neoplasm of the small intestine (HP:0100833)2.12433524
88Disinhibition (HP:0000734)2.11801885
89Flat acetabular roof (HP:0003180)2.11160125
90Verrucae (HP:0200043)2.08478885
91Papilloma (HP:0012740)2.08478885
92Esophageal varix (HP:0002040)2.05154791
93Episodic fever (HP:0001954)2.01571056
94Nasal polyposis (HP:0100582)2.01037542
95Osteolytic defects of the hand bones (HP:0009699)2.00650550
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.00650550
97Cerebral aneurysm (HP:0004944)2.00556152
98Viral hepatitis (HP:0006562)2.00117596
99Ureteral stenosis (HP:0000071)2.00113346
100Abnormality of the nasal mucosa (HP:0000433)1.99717978
101Abnormality of T cell physiology (HP:0011840)1.99058004
102Abnormality of the gastric mucosa (HP:0004295)1.98432887
103Urticaria (HP:0001025)1.97883331
104Recurrent gram-negative bacterial infections (HP:0005420)1.97776693
105Polygenic inheritance (HP:0010982)1.95395764
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94383709
107Bilateral sensorineural hearing impairment (HP:0008619)1.94017653
108Gastrointestinal dysmotility (HP:0002579)1.92273144
109Thin bony cortex (HP:0002753)1.92189904
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91734920
111Abnormality of polysaccharide metabolism (HP:0011012)1.91734920
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91734920
113Alveolar cell carcinoma (HP:0006519)1.91590528
114Hypergammaglobulinemia (HP:0010702)1.90434846
115Micronodular cirrhosis (HP:0001413)1.90079128
116Gingival bleeding (HP:0000225)1.89247965
117Abnormality of transition element cation homeostasis (HP:0011030)1.88724610
118Amaurosis fugax (HP:0100576)1.87115329
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.86292785
120Neoplasm of the tracheobronchial system (HP:0100552)1.86169939
121Urinary glycosaminoglycan excretion (HP:0003541)1.85883972
122Mucopolysacchariduria (HP:0008155)1.85883972
123Ureteral obstruction (HP:0006000)1.85604955
124Palpitations (HP:0001962)1.85499841
125Abnormality of eosinophils (HP:0001879)1.82796382
126Hoarse voice (HP:0001609)1.81318348
127Subacute progressive viral hepatitis (HP:0006572)1.80319962
128Lymphopenia (HP:0001888)1.79636252
129Chronic obstructive pulmonary disease (HP:0006510)1.79441835
130Obstructive lung disease (HP:0006536)1.79441835
131Dysostosis multiplex (HP:0000943)1.79434054
132Polyneuropathy (HP:0001271)1.79219220
133Thickened calvaria (HP:0002684)1.76733995
134Abnormal protein N-linked glycosylation (HP:0012347)1.74937925
135Abnormal protein glycosylation (HP:0012346)1.74937925
136Abnormal glycosylation (HP:0012345)1.74937925
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74937925
138Osteomyelitis (HP:0002754)1.74793348
139Vasculitis (HP:0002633)1.73952712
140Peritonitis (HP:0002586)1.73938353
141Aortic dissection (HP:0002647)1.72948841
142Decreased circulating renin level (HP:0003351)1.72397744
143Ulnar deviation of the wrist (HP:0003049)1.71855150
144Abnormality of chloride homeostasis (HP:0011422)1.71018003
145Pulmonary infiltrates (HP:0002113)1.68724696
146Skin ulcer (HP:0200042)1.68515644
147Hyperactive renin-angiotensin system (HP:0000841)1.67968431
148Bicuspid aortic valve (HP:0001647)1.66608565
149Acute myeloid leukemia (HP:0004808)1.66175117
150Milia (HP:0001056)1.66064757
151Meningitis (HP:0001287)1.65349719
152Autoimmune hemolytic anemia (HP:0001890)1.65247406
153Goiter (HP:0000853)1.64623592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK104.26904902
2MAP3K103.74984695
3PRPF4B3.63710490
4FLT33.23587973
5TAOK33.00359421
6LRRK22.81325423
7RIPK12.44784014
8LMTK22.40755089
9PTK62.32439565
10ERN12.28761595
11IRAK32.16005905
12TYK22.09097387
13EEF2K2.06239038
14ZAP701.98612508
15JAK31.95544004
16CDK121.91248608
17BRSK21.90847526
18MAP4K11.88492004
19BMPR21.82949582
20FRK1.81937690
21IRAK41.79211366
22MAP3K131.78290155
23TRIB31.77446070
24MAP3K81.76362880
25MST41.72644042
26PKN21.61780760
27IRAK21.58177663
28BLK1.57006528
29KIT1.56848422
30PAK41.52678978
31MARK31.44357658
32EPHB11.43091680
33LATS11.39405371
34NME21.35023102
35RIPK41.31602406
36MAP3K141.30698954
37GRK61.30566991
38ACVR1B1.29885988
39PRKG21.29268078
40RPS6KA41.27116557
41IRAK11.27087891
42DYRK31.26269189
43BTK1.24899468
44TBK11.24607632
45MAP3K11.23619381
46TESK21.23607649
47MST1R1.21047074
48CSF1R1.18023356
49STK241.14085806
50MET1.13986217
51TAOK11.13592197
52STK31.07328164
53LYN1.06387360
54TGFBR11.06241787
55TAOK21.05487390
56WEE11.03748457
57MAP3K61.02262085
58RPS6KB21.00670655
59FGR0.99610238
60MAPKAPK30.97816461
61MAP3K50.97740307
62MATK0.96800713
63STK38L0.96662326
64MAP2K20.95811666
65MAP2K30.94976601
66PIM20.93295203
67MYLK0.90057410
68TNK20.89862777
69TXK0.88995603
70EPHA30.88765466
71PIK3CG0.87794058
72PINK10.86989931
73JAK20.85225731
74TGFBR20.83285526
75TESK10.83263508
76TEC0.82017156
77IKBKB0.81961513
78LATS20.80002118
79JAK10.79125929
80MAP3K110.78790626
81KDR0.77153212
82MAPKAPK20.76457194
83DMPK0.76129753
84MAP2K60.74544024
85SYK0.74369933
86ITK0.70645567
87BRD40.70598336
88EPHB20.70277207
89HIPK20.70216907
90GRK70.68530337
91RPS6KA20.67231221
92YES10.67121552
93CAMK1D0.66492836
94CHUK0.65488362
95NME10.64705700
96MAP3K30.63361901
97PTK20.63121739
98MOS0.62952300
99MAPK70.61046409
100CDK60.60636199
101CLK10.59327042
102PRKCQ0.58995262
103PDPK10.57917256
104MAP3K70.57824559
105MAPK120.57123311
106BMPR1B0.56451885
107GSK3A0.55818652
108CDC42BPA0.55550256
109PDK10.54915473
110IKBKE0.54792987
111CSK0.54062740
112PIM10.53268953
113NEK20.52968174
114PRKAA20.47296192
115OXSR10.45769353
116FGFR30.44559944
117MARK20.43767497
118LCK0.41144632
119RPS6KC10.38972584
120RPS6KL10.38972584
121MAPK110.38735124
122TTN0.38646214
123PDGFRB0.37736536
124MAPK30.36668143
125EGFR0.35490893
126PAK10.35421013
127STK390.34807637
128ABL10.34124884
129STK40.33498441
130RPS6KA60.33225546
131MELK0.32701786
132TRPM70.32154294
133CDC70.32105292
134FES0.31193367
135RPS6KA10.31055126
136PRKCD0.30788064
137FGFR40.30660102
138NTRK10.30415164
139MAPK40.30013400
140CDK40.29111154
141SIK10.28757939
142HCK0.27962694

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.62220835
2Asthma_Homo sapiens_hsa053102.35404553
3Antigen processing and presentation_Homo sapiens_hsa046122.19151001
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.10524753
5* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.04067589
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.02204220
7Osteoclast differentiation_Homo sapiens_hsa043801.97534672
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.96153401
9Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.95718935
10Renin-angiotensin system_Homo sapiens_hsa046141.95628751
11Caffeine metabolism_Homo sapiens_hsa002321.85397198
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.77685297
13Mineral absorption_Homo sapiens_hsa049781.77343423
14Toxoplasmosis_Homo sapiens_hsa051451.73760786
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.73700995
16N-Glycan biosynthesis_Homo sapiens_hsa005101.71167739
17Staphylococcus aureus infection_Homo sapiens_hsa051501.69638845
18Sulfur metabolism_Homo sapiens_hsa009201.64731983
19TNF signaling pathway_Homo sapiens_hsa046681.59279439
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58331046
21Allograft rejection_Homo sapiens_hsa053301.58213411
22Chronic myeloid leukemia_Homo sapiens_hsa052201.55833582
23Apoptosis_Homo sapiens_hsa042101.55751161
24Galactose metabolism_Homo sapiens_hsa000521.52173113
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.51110704
26Graft-versus-host disease_Homo sapiens_hsa053321.50963932
27Legionellosis_Homo sapiens_hsa051341.49559570
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.46965033
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42884476
30Pertussis_Homo sapiens_hsa051331.41700281
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.35287558
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33528889
33B cell receptor signaling pathway_Homo sapiens_hsa046621.31828180
34Rheumatoid arthritis_Homo sapiens_hsa053231.30950052
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29983717
36Measles_Homo sapiens_hsa051621.28590379
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27363770
38Tuberculosis_Homo sapiens_hsa051521.27283203
39Hepatitis B_Homo sapiens_hsa051611.25802752
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25550300
41Acute myeloid leukemia_Homo sapiens_hsa052211.25416714
42Autoimmune thyroid disease_Homo sapiens_hsa053201.22872157
43Small cell lung cancer_Homo sapiens_hsa052221.21691802
44Herpes simplex infection_Homo sapiens_hsa051681.20922629
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20356678
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19583928
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17718016
48Viral carcinogenesis_Homo sapiens_hsa052031.15260123
49Lysosome_Homo sapiens_hsa041421.13685873
50Fat digestion and absorption_Homo sapiens_hsa049751.13301825
51Influenza A_Homo sapiens_hsa051641.11480567
52Pancreatic cancer_Homo sapiens_hsa052121.09764877
53Shigellosis_Homo sapiens_hsa051311.08488984
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07353197
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.05572402
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04468321
57Jak-STAT signaling pathway_Homo sapiens_hsa046301.02830101
58Type I diabetes mellitus_Homo sapiens_hsa049401.02754267
59Dorso-ventral axis formation_Homo sapiens_hsa043201.01865894
60Hepatitis C_Homo sapiens_hsa051601.01550604
61Hematopoietic cell lineage_Homo sapiens_hsa046400.99880082
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99173014
63Salmonella infection_Homo sapiens_hsa051320.97580117
64Cell cycle_Homo sapiens_hsa041100.97187448
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96116002
66Chemokine signaling pathway_Homo sapiens_hsa040620.95608314
67Thyroid cancer_Homo sapiens_hsa052160.95129247
68Systemic lupus erythematosus_Homo sapiens_hsa053220.93683009
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92997941
70Pentose phosphate pathway_Homo sapiens_hsa000300.90848883
71Starch and sucrose metabolism_Homo sapiens_hsa005000.89823360
72Other glycan degradation_Homo sapiens_hsa005110.88522554
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86041484
74Platelet activation_Homo sapiens_hsa046110.81032417
75Malaria_Homo sapiens_hsa051440.80897578
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.80229146
77Fatty acid biosynthesis_Homo sapiens_hsa000610.79826724
78VEGF signaling pathway_Homo sapiens_hsa043700.79743451
79Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79373400
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76942830
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.76721053
82Thyroid hormone synthesis_Homo sapiens_hsa049180.76085305
83HTLV-I infection_Homo sapiens_hsa051660.72927350
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72416667
85Insulin resistance_Homo sapiens_hsa049310.72326354
86Vitamin digestion and absorption_Homo sapiens_hsa049770.71508635
87Proteoglycans in cancer_Homo sapiens_hsa052050.71281769
88Epstein-Barr virus infection_Homo sapiens_hsa051690.70645581
89MicroRNAs in cancer_Homo sapiens_hsa052060.70116547
90Prolactin signaling pathway_Homo sapiens_hsa049170.69663921
91Renal cell carcinoma_Homo sapiens_hsa052110.67742089
92Sphingolipid metabolism_Homo sapiens_hsa006000.66825261
93DNA replication_Homo sapiens_hsa030300.63537952
94Viral myocarditis_Homo sapiens_hsa054160.62718053
95Amoebiasis_Homo sapiens_hsa051460.61988434
96FoxO signaling pathway_Homo sapiens_hsa040680.60726029
97Type II diabetes mellitus_Homo sapiens_hsa049300.60468468
98Non-small cell lung cancer_Homo sapiens_hsa052230.59436330
99GnRH signaling pathway_Homo sapiens_hsa049120.57987694
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57906296
101Primary immunodeficiency_Homo sapiens_hsa053400.57287431
102ABC transporters_Homo sapiens_hsa020100.55602409
103Endometrial cancer_Homo sapiens_hsa052130.55550717
104Choline metabolism in cancer_Homo sapiens_hsa052310.54016467
105HIF-1 signaling pathway_Homo sapiens_hsa040660.53290418
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52874190
107Adherens junction_Homo sapiens_hsa045200.51159888
108Colorectal cancer_Homo sapiens_hsa052100.50934286
109Prostate cancer_Homo sapiens_hsa052150.50241894
110Phagosome_Homo sapiens_hsa041450.50215581
111Fructose and mannose metabolism_Homo sapiens_hsa000510.50108273
112mTOR signaling pathway_Homo sapiens_hsa041500.47217011
113T cell receptor signaling pathway_Homo sapiens_hsa046600.46532797
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46243804
115Bladder cancer_Homo sapiens_hsa052190.45795945
116Focal adhesion_Homo sapiens_hsa045100.45759688
117p53 signaling pathway_Homo sapiens_hsa041150.45591446
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.44472779
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.44303110
120Glutathione metabolism_Homo sapiens_hsa004800.42072326
121African trypanosomiasis_Homo sapiens_hsa051430.41917543
122Inositol phosphate metabolism_Homo sapiens_hsa005620.40893778
123Protein digestion and absorption_Homo sapiens_hsa049740.40224513
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39651499
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38478806
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38101281
127Notch signaling pathway_Homo sapiens_hsa043300.36882426
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.36735230
129MAPK signaling pathway_Homo sapiens_hsa040100.36247195
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36205350
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33871128
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.33823765
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.33362553
134ErbB signaling pathway_Homo sapiens_hsa040120.29650732

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