FUT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)6.92547735
2angiotensin maturation (GO:0002003)6.79848444
3positive regulation of respiratory burst (GO:0060267)6.53981116
4intestinal absorption (GO:0050892)6.52889708
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.89942420
6maintenance of gastrointestinal epithelium (GO:0030277)5.67737162
7desmosome organization (GO:0002934)5.37181417
8positive regulation of guanylate cyclase activity (GO:0031284)5.13358048
9positive regulation of pseudopodium assembly (GO:0031274)5.06428277
10regulation of cellular extravasation (GO:0002691)5.05086375
11antibacterial humoral response (GO:0019731)5.03560362
12O-glycan processing (GO:0016266)4.99782652
13antimicrobial humoral response (GO:0019730)4.97860939
14glomerular filtration (GO:0003094)4.97107168
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.93829834
16NADH metabolic process (GO:0006734)4.89748906
17regulation of respiratory burst (GO:0060263)4.81173816
18calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.79763479
19cellular glucuronidation (GO:0052695)4.69835213
20renal filtration (GO:0097205)4.69006468
21glucuronate metabolic process (GO:0019585)4.67178513
22uronic acid metabolic process (GO:0006063)4.67178513
23ethanol oxidation (GO:0006069)4.65257003
24regulation of systemic arterial blood pressure by hormone (GO:0001990)4.63347118
25regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.63347118
26endocrine process (GO:0050886)4.63347118
27regulation of pseudopodium assembly (GO:0031272)4.50610711
28epoxygenase P450 pathway (GO:0019373)4.38875779
29receptor guanylyl cyclase signaling pathway (GO:0007168)4.26552358
30flavonoid metabolic process (GO:0009812)4.26275937
31renal system process involved in regulation of blood volume (GO:0001977)4.22046536
32epithelial structure maintenance (GO:0010669)4.21233648
33GDP-mannose metabolic process (GO:0019673)4.16682826
34regulation of systemic arterial blood pressure (GO:0003073)4.15924911
35ethanol metabolic process (GO:0006067)4.10821411
36vitamin transmembrane transport (GO:0035461)4.08815480
37regulation of cGMP biosynthetic process (GO:0030826)4.05672566
38bile acid and bile salt transport (GO:0015721)3.94409075
39positive regulation of Cdc42 GTPase activity (GO:0043089)3.88099018
40regulation of vitamin metabolic process (GO:0030656)3.80946862
41transcytosis (GO:0045056)3.76930436
42multicellular organismal water homeostasis (GO:0050891)3.75861395
43fat-soluble vitamin biosynthetic process (GO:0042362)3.73416363
44digestive system process (GO:0022600)3.73402813
45phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.72904360
46complement activation, classical pathway (GO:0006958)3.72760482
47primary alcohol catabolic process (GO:0034310)3.72721096
48auditory receptor cell differentiation (GO:0042491)3.72458775
49regulation of bile acid biosynthetic process (GO:0070857)3.69954778
50urea cycle (GO:0000050)3.68344390
51drug metabolic process (GO:0017144)3.68227338
52sulfate transmembrane transport (GO:1902358)3.65139237
53arginine metabolic process (GO:0006525)3.63226998
54regulation of cholesterol homeostasis (GO:2000188)3.56484683
55intestinal epithelial cell development (GO:0060576)3.53553822
56diacylglycerol metabolic process (GO:0046339)3.50865463
57positive regulation of glycoprotein biosynthetic process (GO:0010560)3.42894598
58urea metabolic process (GO:0019627)3.42682213
59nucleoside diphosphate biosynthetic process (GO:0009133)3.40091024
60phosphatidylserine acyl-chain remodeling (GO:0036150)3.37401189
61digestion (GO:0007586)3.36200739
62glucocorticoid biosynthetic process (GO:0006704)3.32927527
63positive regulation of glycoprotein metabolic process (GO:1903020)3.32191543
64lipoprotein transport (GO:0042953)3.31039944
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26565459
66regulation of cGMP metabolic process (GO:0030823)3.26292482
67glutathione biosynthetic process (GO:0006750)3.23975563
68fucose catabolic process (GO:0019317)3.20559037
69L-fucose metabolic process (GO:0042354)3.20559037
70L-fucose catabolic process (GO:0042355)3.20559037
71fructose metabolic process (GO:0006000)3.18971293
72nitrogen cycle metabolic process (GO:0071941)3.17876822
73sodium ion homeostasis (GO:0055078)3.17299903
74hormone catabolic process (GO:0042447)3.16610424
75eosinophil chemotaxis (GO:0048245)3.15618149
76protein O-linked glycosylation (GO:0006493)3.12328968
77nonribosomal peptide biosynthetic process (GO:0019184)3.10016441
78actin filament depolymerization (GO:0030042)3.08009487
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07209961
80excretion (GO:0007588)3.06768799
81water homeostasis (GO:0030104)3.06683707
82arginine catabolic process (GO:0006527)3.04370363
83phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.02590456
84transepithelial transport (GO:0070633)3.02149046
85sphingomyelin metabolic process (GO:0006684)2.99695604
86nucleotide-sugar biosynthetic process (GO:0009226)2.99491006
87drug catabolic process (GO:0042737)2.98804179
88regulation of water loss via skin (GO:0033561)2.97651433
89pyrimidine-containing compound transmembrane transport (GO:0072531)2.97468416
90sperm capacitation (GO:0048240)2.97428939
91peptide catabolic process (GO:0043171)2.95960121
92negative regulation of keratinocyte proliferation (GO:0010839)2.95058342
93primary alcohol metabolic process (GO:0034308)2.93473869
94diterpenoid biosynthetic process (GO:0016102)2.92606334
95sulfate transport (GO:0008272)2.91095956
96renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.90043059
97exogenous drug catabolic process (GO:0042738)2.87034562
983-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.86991661
99purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.86991661
100antigen processing and presentation of endogenous antigen (GO:0019883)2.86484099

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.61342853
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.93757164
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.43116545
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.11071463
5GATA4_25053715_ChIP-Seq_YYC3_Human3.05521438
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.87835733
7SOX2_20726797_ChIP-Seq_SW620_Human2.84995714
8GATA6_25053715_ChIP-Seq_YYC3_Human2.84438059
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.54720263
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.51229661
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44170175
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.44168131
13SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34365930
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.34183630
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.33474271
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.24679829
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.22741407
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22635277
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.17621941
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.15957020
21PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04358287
22RXR_22158963_ChIP-Seq_LIVER_Mouse1.98926128
23P63_26484246_Chip-Seq_KERATINOCYTES_Human1.92467562
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.85797319
25KLF5_25053715_ChIP-Seq_YYC3_Human1.83502818
26RACK7_27058665_Chip-Seq_MCF-7_Human1.79434209
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79127832
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.75687676
29IRF8_22096565_ChIP-ChIP_GC-B_Human1.74970234
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73064178
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.72025616
32LXR_22158963_ChIP-Seq_LIVER_Mouse1.70698672
33ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68109580
34BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.67790668
35ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66386421
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.65978397
37PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.64733748
38TCF4_18268006_ChIP-ChIP_LS174T_Human1.64554899
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61377495
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59225394
41EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58259614
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55279561
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54540022
44LXR_22292898_ChIP-Seq_THP-1_Human1.52743961
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52197403
46DROSHA_22980978_ChIP-Seq_HELA_Human1.47466730
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45847525
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42750838
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.35518189
50* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31955180
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.29918969
52FOXA1_25552417_ChIP-Seq_VCAP_Human1.28647426
53TP63_22573176_ChIP-Seq_HFKS_Human1.21500899
54CDX2_22108803_ChIP-Seq_LS180_Human1.19066850
55SA1_27219007_Chip-Seq_Bcells_Human1.18992255
56FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18482470
57CTCF_27219007_Chip-Seq_Bcells_Human1.15643865
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14941813
59* CEBPB_22108803_ChIP-Seq_LS180_Human1.12371704
60* BCL6_27268052_Chip-Seq_Bcells_Human1.11525647
61STAT1_20625510_ChIP-Seq_HELA_Human1.11307172
62ZNF263_19887448_ChIP-Seq_K562_Human1.11279548
63* BCOR_27268052_Chip-Seq_Bcells_Human1.11068263
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07310349
65NANOG_20526341_ChIP-Seq_ESCs_Human1.03948882
66RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03873334
67HNF4A_19822575_ChIP-Seq_HepG2_Human1.02858524
68TET1_21451524_ChIP-Seq_MESCs_Mouse1.02515271
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00865583
70* E2F1_20622854_ChIP-Seq_HELA_Human1.00779431
71BP1_19119308_ChIP-ChIP_Hs578T_Human0.99966045
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99301204
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99301204
74JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98301394
75CREB1_26743006_Chip-Seq_LNCaP_Human0.98245371
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97519461
77ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97484575
78SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96148554
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95880224
80SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95435876
81CTCF_20526341_ChIP-Seq_ESCs_Human0.95145824
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94423205
83FOXA2_19822575_ChIP-Seq_HepG2_Human0.93414022
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.91744478
85CLOCK_20551151_ChIP-Seq_293T_Human0.91237915
86* PHF8_20622854_ChIP-Seq_HELA_Human0.89294721
87SMC4_20622854_ChIP-Seq_HELA_Human0.88481143
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88375154
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87781054
90SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.87463674
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.87375570
92TP63_23658742_ChIP-Seq_EP156T_Human0.86187315
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83425824
94P300_27268052_Chip-Seq_Bcells_Human0.82979538
95P53_21459846_ChIP-Seq_SAOS-2_Human0.82088921
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80550606
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79972411
98* ATF3_27146783_Chip-Seq_COLON_Human0.79854716
99AR_21909140_ChIP-Seq_LNCAP_Human0.79457143
100EGR1_19032775_ChIP-ChIP_M12_Human0.79414780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.52218420
2MP0005360_urolithiasis4.98580711
3MP0002139_abnormal_hepatobiliary_system4.38287190
4MP0004264_abnormal_extraembryonic_tissu3.63367022
5MP0004043_abnormal_pH_regulation3.63139081
6MP0001666_abnormal_nutrient_absorption3.56315808
7MP0005085_abnormal_gallbladder_physiolo3.41481550
8MP0009379_abnormal_foot_pigmentation3.22989840
9MP0010155_abnormal_intestine_physiology3.12108388
10MP0010352_gastrointestinal_tract_polyps2.98453217
11MP0003866_abnormal_defecation2.81923321
12MP0002796_impaired_skin_barrier2.74639423
13MP0004019_abnormal_vitamin_homeostasis2.69664392
14MP0005365_abnormal_bile_salt2.69345720
15MP0003183_abnormal_peptide_metabolism2.55601466
16MP0001664_abnormal_digestion2.37182444
17MP0004782_abnormal_surfactant_physiolog2.11913100
18MP0000490_abnormal_crypts_of2.09746580
19MP0000477_abnormal_intestine_morphology2.08023646
20MP0004147_increased_porphyrin_level1.98396373
21MP0001873_stomach_inflammation1.96369556
22MP0001765_abnormal_ion_homeostasis1.96071596
23MP0002098_abnormal_vibrissa_morphology1.90783474
24MP0005409_darkened_coat_color1.88852397
25MP0001663_abnormal_digestive_system1.85730031
26MP0000678_abnormal_parathyroid_gland1.84867871
27MP0009840_abnormal_foam_cell1.83101055
28MP0000566_synostosis1.80916846
29MP0004858_abnormal_nervous_system1.63638611
30MP0005501_abnormal_skin_physiology1.63570708
31MP0000465_gastrointestinal_hemorrhage1.62580766
32MP0005381_digestive/alimentary_phenotyp1.61477310
33MP0002876_abnormal_thyroid_physiology1.56929275
34MP0005166_decreased_susceptibility_to1.56372737
35MP0009643_abnormal_urine_homeostasis1.55084674
36MP0010678_abnormal_skin_adnexa1.53121247
37MP0002138_abnormal_hepatobiliary_system1.52603582
38MP0008875_abnormal_xenobiotic_pharmacok1.51883981
39MP0003806_abnormal_nucleotide_metabolis1.43952939
40MP0005636_abnormal_mineral_homeostasis1.42109917
41MP0000467_abnormal_esophagus_morphology1.41593304
42MP0001188_hyperpigmentation1.29704795
43MP0000462_abnormal_digestive_system1.28837116
44MP0005332_abnormal_amino_acid1.26241725
45MP0002136_abnormal_kidney_physiology1.23971441
46MP0003252_abnormal_bile_duct1.23064970
47MP0000537_abnormal_urethra_morphology1.21463536
48MP0003868_abnormal_feces_composition1.20946627
49MP0001756_abnormal_urination1.16865452
50MP0001216_abnormal_epidermal_layer1.15376940
51MP0005670_abnormal_white_adipose1.09428948
52MP0003453_abnormal_keratinocyte_physiol1.08507706
53MP0001485_abnormal_pinna_reflex1.06230721
54MP0010329_abnormal_lipoprotein_level1.05675366
55MP0005451_abnormal_body_composition0.97908946
56MP0000538_abnormal_urinary_bladder0.97784990
57MP0001764_abnormal_homeostasis0.97628050
58MP0008004_abnormal_stomach_pH0.95806738
59MP0008872_abnormal_physiological_respon0.95109438
60MP0002822_catalepsy0.93750792
61MP0003879_abnormal_hair_cell0.85842685
62MP0003724_increased_susceptibility_to0.84593592
63MP0005310_abnormal_salivary_gland0.83016314
64MP0000377_abnormal_hair_follicle0.82112133
65MP0004947_skin_inflammation0.81719750
66MP0003693_abnormal_embryo_hatching0.81702770
67MP0002118_abnormal_lipid_homeostasis0.79486342
68MP0001501_abnormal_sleep_pattern0.78000759
69MP0000230_abnormal_systemic_arterial0.77606234
70MP0002166_altered_tumor_susceptibility0.75905002
71MP0000470_abnormal_stomach_morphology0.74874089
72MP0001845_abnormal_inflammatory_respons0.74807740
73MP0009785_altered_susceptibility_to0.74681095
74MP0005319_abnormal_enzyme/_coenzyme0.73946331
75MP0003315_abnormal_perineum_morphology0.73812283
76MP0003191_abnormal_cellular_cholesterol0.73586894
77MP0001849_ear_inflammation0.73102212
78MP0000579_abnormal_nail_morphology0.71363127
79MP0005083_abnormal_biliary_tract0.69395654
80MP0001881_abnormal_mammary_gland0.67891486
81MP0003718_maternal_effect0.66516082
82MP0005165_increased_susceptibility_to0.66295083
83MP0003329_amyloid_beta_deposits0.66038148
84MP0002896_abnormal_bone_mineralization0.65739063
85MP0005584_abnormal_enzyme/coenzyme_acti0.64880786
86MP0000609_abnormal_liver_physiology0.63814408
87MP0000762_abnormal_tongue_morphology0.62445034
88MP0010771_integument_phenotype0.61028819
89MP0005025_abnormal_response_to0.60721609
90MP0005387_immune_system_phenotype0.59939659
91MP0001790_abnormal_immune_system0.59939659
92MP0000383_abnormal_hair_follicle0.59592886
93MP0005023_abnormal_wound_healing0.59530677
94MP0002277_abnormal_respiratory_mucosa0.58808384
95MP0005448_abnormal_energy_balance0.57931748
96MP0002006_tumorigenesis0.57643626
97MP0000681_abnormal_thyroid_gland0.55452602
98MP0000627_abnormal_mammary_gland0.55176431
99MP0003941_abnormal_skin_development0.52189842
100MP0009931_abnormal_skin_appearance0.52089444

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)7.89222666
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.92592212
3Decreased circulating renin level (HP:0003351)6.26741164
4Malnutrition (HP:0004395)6.05016947
5Abnormality of renin-angiotensin system (HP:0000847)5.56422732
6Metabolic alkalosis (HP:0200114)5.05195906
7Ileus (HP:0002595)4.42342837
8Right ventricular cardiomyopathy (HP:0011663)4.41928944
9Abnormality of proline metabolism (HP:0010907)4.38373029
10Hydroxyprolinuria (HP:0003080)4.38373029
11Alkalosis (HP:0001948)4.36912741
12Abnormality of chloride homeostasis (HP:0011422)4.27698262
13Pili torti (HP:0003777)4.17516989
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.03864116
15Hyperaldosteronism (HP:0000859)3.97496542
16Systemic lupus erythematosus (HP:0002725)3.90691800
17Chronic diarrhea (HP:0002028)3.87859680
18Chronic bronchitis (HP:0004469)3.78668662
19Flat acetabular roof (HP:0003180)3.60831196
20Abnormal hair laboratory examination (HP:0003328)3.53788251
21Congenital sensorineural hearing impairment (HP:0008527)3.51532512
22Abnormality of the vitamin B12 metabolism (HP:0004341)3.41608633
23Abnormality of small intestinal villus morphology (HP:0011472)3.39396130
24Villous atrophy (HP:0011473)3.39396130
25Fat malabsorption (HP:0002630)3.25867144
26Abnormality of vitamin B metabolism (HP:0004340)3.17686313
27Abnormality of the nasal mucosa (HP:0000433)3.10826232
28Hemorrhage of the eye (HP:0011885)3.05545578
29Abdominal distention (HP:0003270)3.04702984
30Widely patent fontanelles and sutures (HP:0004492)2.92222657
31Hyponatremia (HP:0002902)2.91733572
32Nasal polyposis (HP:0100582)2.89082763
33Dehydration (HP:0001944)2.79756118
34Abnormality of vitamin metabolism (HP:0100508)2.79152422
35Hyperkalemia (HP:0002153)2.69210481
36Focal segmental glomerulosclerosis (HP:0000097)2.68088191
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62887307
38Hypokalemia (HP:0002900)2.61601110
39Intrahepatic cholestasis (HP:0001406)2.60999329
40Conjugated hyperbilirubinemia (HP:0002908)2.60028869
41Abnormality of potassium homeostasis (HP:0011042)2.51528366
42Alopecia of scalp (HP:0002293)2.50813936
43Hypotension (HP:0002615)2.48984753
44Renal salt wasting (HP:0000127)2.47269773
45Confusion (HP:0001289)2.44214446
46Hyperammonemia (HP:0001987)2.41673718
47Glomerulonephritis (HP:0000099)2.40032108
48Plantar hyperkeratosis (HP:0007556)2.39357378
49Hyperphosphatemia (HP:0002905)2.38221663
50Glomerulosclerosis (HP:0000096)2.36323932
51Bronchiectasis (HP:0002110)2.32978673
52Thin bony cortex (HP:0002753)2.32111005
53Palmoplantar hyperkeratosis (HP:0000972)2.31243019
54Abnormality of urine glucose concentration (HP:0011016)2.30669316
55Glycosuria (HP:0003076)2.30669316
56Hyperparathyroidism (HP:0000843)2.23658813
57Nephritis (HP:0000123)2.22516458
58Curly hair (HP:0002212)2.22171627
59Acanthocytosis (HP:0001927)2.20702723
60Hypobetalipoproteinemia (HP:0003563)2.20111617
61Syncope (HP:0001279)2.19080551
62Hyperglycinuria (HP:0003108)2.17586600
63Abnormal biliary tract morphology (HP:0012440)2.16488913
64Posterior subcapsular cataract (HP:0007787)2.15746877
65Palmar hyperkeratosis (HP:0010765)2.14216933
66Bronchitis (HP:0012387)2.13687336
67Abnormality of sodium homeostasis (HP:0010931)2.12594659
68Pigmentary retinal degeneration (HP:0001146)2.12365087
69Proximal tubulopathy (HP:0000114)2.12018032
70Abnormality of complement system (HP:0005339)2.11502282
71Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10624337
72Dicarboxylic aciduria (HP:0003215)2.10624337
73Adrenal overactivity (HP:0002717)2.06843088
74Increased purine levels (HP:0004368)2.05760032
75Hyperuricemia (HP:0002149)2.05760032
76Abnormal tarsal ossification (HP:0008369)2.04638001
77Abnormality of serine family amino acid metabolism (HP:0010894)2.03883063
78Abnormality of glycine metabolism (HP:0010895)2.03883063
79Complement deficiency (HP:0004431)2.03570756
80Eczematoid dermatitis (HP:0000976)2.03089999
81Woolly hair (HP:0002224)2.02280741
82Rhinitis (HP:0012384)2.01538042
83Metabolic acidosis (HP:0001942)1.97823789
84Wide cranial sutures (HP:0010537)1.95819787
85Pustule (HP:0200039)1.95263912
86Abnormal respiratory motile cilium physiology (HP:0012261)1.94329789
87Cerebral palsy (HP:0100021)1.94209007
88Abnormality of pyrimidine metabolism (HP:0004353)1.92880985
89Gout (HP:0001997)1.92567081
90Nephrolithiasis (HP:0000787)1.91494353
91Congenital ichthyosiform erythroderma (HP:0007431)1.86072379
92Abnormal respiratory motile cilium morphology (HP:0005938)1.84495456
93Abnormal respiratory epithelium morphology (HP:0012253)1.84495456
94Ventricular fibrillation (HP:0001663)1.82272920
95Mildly elevated creatine phosphokinase (HP:0008180)1.81718393
96Abnormality of magnesium homeostasis (HP:0004921)1.81436597
97Flattened epiphyses (HP:0003071)1.79727272
98Premature loss of primary teeth (HP:0006323)1.79164173
99Steatorrhea (HP:0002570)1.77762754
100Abnormality of nucleobase metabolism (HP:0010932)1.77756067

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.51169816
2EPHA26.66462143
3ACVR1B5.01237034
4RIPK13.42924996
5LMTK23.29139993
6ERN13.24473656
7MET3.08900545
8PIK3CA2.85889140
9EPHB22.51514495
10STK392.38820690
11MST42.30515686
12PRKG22.27345267
13STK241.78185122
14OXSR11.76110503
15MAP3K21.62384103
16FGFR41.57055739
17EPHA31.51438272
18MAP3K121.49095825
19NME11.48165992
20PTK61.45461229
21MAP3K101.35606623
22EPHB11.34252074
23FER1.31185480
24WNK41.21648329
25TESK11.18239279
26PDK21.11797724
27MATK1.02249608
28ERBB20.98592556
29MAPK150.94518655
30DDR20.90743022
31MAP2K60.88917120
32TESK20.84879739
33PRKCI0.84130498
34TAOK10.82057855
35MYLK0.81446140
36TYK20.80301011
37MAPKAPK30.79285636
38CDC42BPA0.78088970
39MAP2K20.77286804
40GRK60.75340518
41FGFR30.74763793
42PTK20.73429343
43MAP3K10.72361538
44PAK40.71946599
45CDK190.70972672
46SMG10.68901859
47IRAK10.65009100
48MAP3K30.64291413
49TNIK0.59018058
50PRKAA20.57024147
51GRK10.57009644
52PDPK10.53132667
53ABL20.51414112
54CASK0.51081226
55NLK0.49684709
56CAMK2D0.48417559
57EPHA40.47389992
58BCR0.41673224
59PBK0.41325848
60PRKCA0.41043149
61SRC0.40309587
62TBK10.36724489
63DMPK0.35816390
64NEK60.35114997
65LATS10.34973159
66BMX0.33666986
67PRKCZ0.33158960
68FRK0.32928739
69MAP4K10.32789205
70ZAP700.32559871
71MAP3K60.32540856
72PRKACG0.30684242
73PRKCD0.30389354
74YES10.29841199
75MAPK110.28848134
76CSNK1A10.28318512
77MAPKAPK20.25198568
78CAMK2G0.24094866
79IRAK30.23170846
80SIK30.21987601
81CSK0.21680165
82IGF1R0.21181690
83MAP3K110.20682053
84PDK10.20611227
85KSR20.20212091
86DYRK1B0.19509243
87MAP2K10.17002757
88FYN0.16839512
89MAP3K80.15840646
90INSRR0.15678245
91RIPK40.15379560
92LRRK20.14151593
93BMPR20.14073350
94ERBB30.13917648
95TRIB30.12444172
96RPS6KA20.11128715
97STK30.10998505
98IKBKE0.10805576
99PIM20.09053032
100RET0.07666454

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.98659260
2Fat digestion and absorption_Homo sapiens_hsa049753.55891928
3Sulfur metabolism_Homo sapiens_hsa009203.43435386
4Caffeine metabolism_Homo sapiens_hsa002322.75223431
5Arginine biosynthesis_Homo sapiens_hsa002202.58564250
6Mineral absorption_Homo sapiens_hsa049782.53378266
7Histidine metabolism_Homo sapiens_hsa003402.53057756
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.52905328
9Renin-angiotensin system_Homo sapiens_hsa046142.46134590
10* Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.44094317
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34923291
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.31052361
13Vitamin digestion and absorption_Homo sapiens_hsa049772.28455359
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15237506
15Chemical carcinogenesis_Homo sapiens_hsa052042.14430650
16Fructose and mannose metabolism_Homo sapiens_hsa000512.11909946
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11218932
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.05533081
19Retinol metabolism_Homo sapiens_hsa008302.03656776
20Starch and sucrose metabolism_Homo sapiens_hsa005001.84948907
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.83004263
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.72900524
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68613330
24Protein digestion and absorption_Homo sapiens_hsa049741.66974726
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.63308984
26Linoleic acid metabolism_Homo sapiens_hsa005911.61297220
27Fatty acid degradation_Homo sapiens_hsa000711.61073216
28Arginine and proline metabolism_Homo sapiens_hsa003301.49237802
29Galactose metabolism_Homo sapiens_hsa000521.45197050
30Bile secretion_Homo sapiens_hsa049761.45039459
31Nitrogen metabolism_Homo sapiens_hsa009101.42465780
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35167330
33PPAR signaling pathway_Homo sapiens_hsa033201.34705510
34Asthma_Homo sapiens_hsa053101.32442243
35Arachidonic acid metabolism_Homo sapiens_hsa005901.31785389
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30787876
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.28902904
38Glutathione metabolism_Homo sapiens_hsa004801.25354354
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25156760
40Phenylalanine metabolism_Homo sapiens_hsa003601.23278125
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.22165280
42Glycerolipid metabolism_Homo sapiens_hsa005611.17659077
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.16790919
44Pancreatic secretion_Homo sapiens_hsa049721.16050504
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06986163
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06374260
47Tryptophan metabolism_Homo sapiens_hsa003801.01317415
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99012416
49Ether lipid metabolism_Homo sapiens_hsa005650.96392460
50Tyrosine metabolism_Homo sapiens_hsa003500.94426752
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90450901
52Allograft rejection_Homo sapiens_hsa053300.86843508
53Autoimmune thyroid disease_Homo sapiens_hsa053200.83620196
54Staphylococcus aureus infection_Homo sapiens_hsa051500.77903957
55Graft-versus-host disease_Homo sapiens_hsa053320.77095978
56Tight junction_Homo sapiens_hsa045300.73903608
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73814128
58Sphingolipid metabolism_Homo sapiens_hsa006000.71720838
59Peroxisome_Homo sapiens_hsa041460.66852022
60Type I diabetes mellitus_Homo sapiens_hsa049400.61297152
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.58065528
62Other glycan degradation_Homo sapiens_hsa005110.54032918
63Sulfur relay system_Homo sapiens_hsa041220.52248154
64Fatty acid metabolism_Homo sapiens_hsa012120.50146744
65Hepatitis C_Homo sapiens_hsa051600.45168928
66Thyroid hormone synthesis_Homo sapiens_hsa049180.44983757
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44908151
68Antigen processing and presentation_Homo sapiens_hsa046120.40533488
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.39993199
70Butanoate metabolism_Homo sapiens_hsa006500.39785181
71beta-Alanine metabolism_Homo sapiens_hsa004100.38228884
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.36196699
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35533411
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34362262
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31997236
76Pertussis_Homo sapiens_hsa051330.31770491
77Propanoate metabolism_Homo sapiens_hsa006400.27781729
78* Metabolic pathways_Homo sapiens_hsa011000.27369684
79Vibrio cholerae infection_Homo sapiens_hsa051100.27073664
80Renin secretion_Homo sapiens_hsa049240.26720066
81Carbon metabolism_Homo sapiens_hsa012000.25594365
82ABC transporters_Homo sapiens_hsa020100.21901889
83Viral myocarditis_Homo sapiens_hsa054160.20368578
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.20070780
85Fatty acid biosynthesis_Homo sapiens_hsa000610.18622096
86Leishmaniasis_Homo sapiens_hsa051400.17768098
87Fatty acid elongation_Homo sapiens_hsa000620.16909683
88Folate biosynthesis_Homo sapiens_hsa007900.16650924
89Insulin resistance_Homo sapiens_hsa049310.14212748
90Pyruvate metabolism_Homo sapiens_hsa006200.14052151
91Biosynthesis of amino acids_Homo sapiens_hsa012300.12471292
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.09794665
93Pentose phosphate pathway_Homo sapiens_hsa000300.09137204
94Toxoplasmosis_Homo sapiens_hsa051450.08840084
95Amoebiasis_Homo sapiens_hsa051460.08266623
96Influenza A_Homo sapiens_hsa051640.05561583
97Salmonella infection_Homo sapiens_hsa051320.05517823
98Salivary secretion_Homo sapiens_hsa049700.03838702
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03757161
100Insulin secretion_Homo sapiens_hsa049110.01794402

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