FURIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49540431
2L-phenylalanine catabolic process (GO:0006559)4.49540431
3L-phenylalanine metabolic process (GO:0006558)4.39135108
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39135108
5negative regulation of erythrocyte differentiation (GO:0045647)4.27049014
6aromatic amino acid family catabolic process (GO:0009074)4.19311145
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.07746738
8urea metabolic process (GO:0019627)4.06137916
9urea cycle (GO:0000050)4.06137916
10regulation of cholesterol homeostasis (GO:2000188)4.05400771
11kynurenine metabolic process (GO:0070189)4.03075632
12tryptophan catabolic process (GO:0006569)3.93330182
13indole-containing compound catabolic process (GO:0042436)3.93330182
14indolalkylamine catabolic process (GO:0046218)3.93330182
15negative regulation of fibrinolysis (GO:0051918)3.89695652
16* peptidyl-glutamic acid carboxylation (GO:0017187)3.89305473
17* protein carboxylation (GO:0018214)3.89305473
18alpha-linolenic acid metabolic process (GO:0036109)3.81339678
19cysteine metabolic process (GO:0006534)3.77769996
20glyoxylate metabolic process (GO:0046487)3.77508770
21tryptophan metabolic process (GO:0006568)3.71434113
22negative regulation of cholesterol transport (GO:0032375)3.68033761
23negative regulation of sterol transport (GO:0032372)3.68033761
24valine metabolic process (GO:0006573)3.67764209
25nitrogen cycle metabolic process (GO:0071941)3.66788874
26lysine metabolic process (GO:0006553)3.65460009
27lysine catabolic process (GO:0006554)3.65460009
28fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64757729
29complement activation, alternative pathway (GO:0006957)3.62776581
30bile acid biosynthetic process (GO:0006699)3.59163280
31sulfur amino acid catabolic process (GO:0000098)3.54234481
32high-density lipoprotein particle remodeling (GO:0034375)3.52783291
33protein localization to endosome (GO:0036010)3.51511949
34mannose metabolic process (GO:0006013)3.50880650
35regulation of fibrinolysis (GO:0051917)3.47791827
36regulation of protein activation cascade (GO:2000257)3.43857412
37homocysteine metabolic process (GO:0050667)3.43182502
38plasma lipoprotein particle clearance (GO:0034381)3.38267399
39plasma lipoprotein particle assembly (GO:0034377)3.33707219
40phospholipid efflux (GO:0033700)3.32124382
41regulation of triglyceride catabolic process (GO:0010896)3.30067543
42response to peptidoglycan (GO:0032494)3.28404878
43amino-acid betaine metabolic process (GO:0006577)3.27769442
44serine family amino acid catabolic process (GO:0009071)3.27260502
45aromatic amino acid family metabolic process (GO:0009072)3.25585834
46detection of other organism (GO:0098543)3.24718622
472-oxoglutarate metabolic process (GO:0006103)3.23882552
48regulation of complement activation (GO:0030449)3.22984482
49negative regulation of cell killing (GO:0031342)3.21035650
50negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.21035650
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.18834568
52detection of bacterium (GO:0016045)3.18683335
53reverse cholesterol transport (GO:0043691)3.17963156
54antigen processing and presentation of endogenous antigen (GO:0019883)3.17451033
55indolalkylamine metabolic process (GO:0006586)3.16765912
56acute-phase response (GO:0006953)3.16132987
57protein-lipid complex assembly (GO:0065005)3.15742821
58tolerance induction (GO:0002507)3.15324417
59positive regulation by symbiont of host defense response (GO:0052509)3.14593279
60modulation by symbiont of host defense response (GO:0052031)3.14593279
61modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.14593279
62modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.14593279
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.14593279
64modulation by symbiont of host immune response (GO:0052553)3.14593279
65phospholipid homeostasis (GO:0055091)3.13895776
66cellular extravasation (GO:0045123)3.07665902
67response to muramyl dipeptide (GO:0032495)3.05737076
68low-density lipoprotein particle clearance (GO:0034383)3.05470880
69bile acid metabolic process (GO:0008206)3.05173750
70dicarboxylic acid biosynthetic process (GO:0043650)3.04514206
71acylglycerol homeostasis (GO:0055090)3.03847660
72triglyceride homeostasis (GO:0070328)3.03847660
73fibrinolysis (GO:0042730)2.98551636
74positive regulation of lipid catabolic process (GO:0050996)2.96892166
75plasma lipoprotein particle remodeling (GO:0034369)2.96743436
76protein-lipid complex remodeling (GO:0034368)2.96743436
77macromolecular complex remodeling (GO:0034367)2.96743436
78regulation of fatty acid beta-oxidation (GO:0031998)2.95875240
79response to laminar fluid shear stress (GO:0034616)2.94466039
80regulation of cholesterol esterification (GO:0010872)2.93134568
81tyrosine phosphorylation of STAT protein (GO:0007260)2.92959085
82germinal center formation (GO:0002467)2.91884901
83pinocytosis (GO:0006907)2.91768337
84regulation of cholesterol storage (GO:0010885)2.91124330
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.89500337
86very-low-density lipoprotein particle assembly (GO:0034379)2.89171403
87JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88384769
88detection of external biotic stimulus (GO:0098581)2.87858640
89neutrophil activation involved in immune response (GO:0002283)2.87390637
90alpha-amino acid catabolic process (GO:1901606)2.87178709
91regulation of gamma-delta T cell activation (GO:0046643)2.86135754
92macrophage activation involved in immune response (GO:0002281)2.84904808
93positive regulation of natural killer cell differentiation (GO:0032825)2.82599042
94NIK/NF-kappaB signaling (GO:0038061)2.82460370
95cellular modified amino acid catabolic process (GO:0042219)2.80680264
96cholesterol efflux (GO:0033344)2.79890256
97growth hormone receptor signaling pathway (GO:0060396)2.79480687
98cellular glucuronidation (GO:0052695)2.78879707
99negative regulation of lipid transport (GO:0032369)2.77770171
100lipopolysaccharide-mediated signaling pathway (GO:0031663)2.76999979
101positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.75107741
1024-hydroxyproline metabolic process (GO:0019471)2.73865040
103plasma lipoprotein particle organization (GO:0071827)2.72980159
104tyrosine metabolic process (GO:0006570)2.72564423
105detection of molecule of bacterial origin (GO:0032490)2.70707582
106benzene-containing compound metabolic process (GO:0042537)2.70239772
107positive regulation of lipid storage (GO:0010884)2.69782084
108glutamate metabolic process (GO:0006536)2.69615835
109glycine metabolic process (GO:0006544)2.68918398
110positive regulation of triglyceride metabolic process (GO:0090208)2.66850724
111protein-lipid complex subunit organization (GO:0071825)2.66467092
112ethanol oxidation (GO:0006069)2.66112189
113response to growth hormone (GO:0060416)2.65995324
114negative regulation of interleukin-12 production (GO:0032695)2.64815420
115cholesterol homeostasis (GO:0042632)2.64753115
116positive regulation of lipoprotein lipase activity (GO:0051006)2.64359116
117positive regulation of triglyceride lipase activity (GO:0061365)2.64359116
118serine family amino acid metabolic process (GO:0009069)2.64340748
119bile acid and bile salt transport (GO:0015721)2.64110928
120modulation by symbiont of host cellular process (GO:0044068)2.63905745
121sterol homeostasis (GO:0055092)2.63723139
122cellular biogenic amine catabolic process (GO:0042402)2.62274968
123amine catabolic process (GO:0009310)2.62274968
124regulation of gamma-delta T cell differentiation (GO:0045586)2.61963473
125positive regulation of gamma-delta T cell activation (GO:0046645)2.61063393
126cellular amino acid catabolic process (GO:0009063)2.60615933
127antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58292477
128antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58292477
129oxaloacetate metabolic process (GO:0006107)2.57908310
130regulation of T-helper 2 cell differentiation (GO:0045628)2.57356171
131tricarboxylic acid metabolic process (GO:0072350)2.57126623
132myeloid dendritic cell differentiation (GO:0043011)2.56047017
133regulation of leukocyte degranulation (GO:0043300)2.55995287
134detection of biotic stimulus (GO:0009595)2.50005610
135barbed-end actin filament capping (GO:0051016)2.49403080
136positive regulation of extracellular matrix organization (GO:1903055)2.47368027
137stress fiber assembly (GO:0043149)2.45985660
138regulation of mast cell degranulation (GO:0043304)2.44622048
139negative regulation of cytokine production involved in immune response (GO:0002719)2.39593405
140regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39527651
141regulation of early endosome to late endosome transport (GO:2000641)2.39148101
142positive regulation of cellular amide metabolic process (GO:0034250)2.38515502
143leukocyte aggregation (GO:0070486)2.37024815
144positive thymic T cell selection (GO:0045059)2.35193343
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31941941
146thymic T cell selection (GO:0045061)2.29346627
147positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.28885974
148regulation of extracellular matrix disassembly (GO:0010715)2.28746736
149positive regulation of receptor recycling (GO:0001921)2.28640387
150* positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.26525806
151positive regulation of Cdc42 GTPase activity (GO:0043089)2.26483639
152modulation by virus of host process (GO:0019054)2.25929345
153cellular response to thyroid hormone stimulus (GO:0097067)2.25342986
154regulation of apoptotic cell clearance (GO:2000425)2.25146174
155regulation of T cell tolerance induction (GO:0002664)2.24953640
156embryonic process involved in female pregnancy (GO:0060136)2.24903388
157hyaluronan catabolic process (GO:0030214)2.24564897
158glycosphingolipid catabolic process (GO:0046479)2.24355102
159basement membrane organization (GO:0071711)2.22786716
160negative regulation of fatty acid transport (GO:2000192)2.20919924
161positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.19117390
162immunoglobulin mediated immune response (GO:0016064)2.18233240
163myeloid dendritic cell activation (GO:0001773)2.15877683
164negative regulation of leukocyte mediated immunity (GO:0002704)2.15139031
165virion attachment to host cell (GO:0019062)2.14271686
166adhesion of symbiont to host cell (GO:0044650)2.14271686
167positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.13835348
168cell-substrate junction assembly (GO:0007044)2.13723602
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.13217304
170regulation of interferon-beta biosynthetic process (GO:0045357)2.12769077
171regulation of mast cell activation involved in immune response (GO:0033006)2.12290576
172angiogenesis involved in wound healing (GO:0060055)2.12012421
173adhesion of symbiont to host (GO:0044406)2.11909337
174response to thyroid hormone (GO:0097066)2.11290670
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.11147904
176negative regulation of lymphocyte mediated immunity (GO:0002707)2.10900032
177regulation of interleukin-2 biosynthetic process (GO:0045076)2.10870995
178regulation of type I interferon-mediated signaling pathway (GO:0060338)2.09712474
179response to interleukin-15 (GO:0070672)2.09237705
180negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.08040402
181type I interferon signaling pathway (GO:0060337)2.07935126
182cellular response to type I interferon (GO:0071357)2.07935126
183apoptotic cell clearance (GO:0043277)2.07855125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.82672276
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.04335644
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.53745395
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.06716193
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.61956172
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.23425456
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.15690811
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.13902050
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.00232441
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.74365528
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.69034273
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.68432085
13* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58750482
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46150027
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.43107966
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.31752053
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.26319206
18CLOCK_20551151_ChIP-Seq_293T_Human2.17693352
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98428324
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90714501
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90558998
22* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.89964279
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.85950743
24EGR1_19374776_ChIP-ChIP_THP-1_Human1.84717828
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84467825
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82770890
27NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81716954
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72515863
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68116679
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.65733475
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64940840
32MYC_22102868_ChIP-Seq_BL_Human1.63734575
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.62859107
34SPI1_23127762_ChIP-Seq_K562_Human1.62106206
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.61284664
36MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60785446
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58931003
38* MAF_26560356_Chip-Seq_TH1_Human1.55803109
39* TCF7_22412390_ChIP-Seq_EML_Mouse1.55154261
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53622576
41KDM2B_26808549_Chip-Seq_K562_Human1.53186479
42* ELK3_25401928_ChIP-Seq_HUVEC_Human1.50023800
43* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48419420
44VDR_21846776_ChIP-Seq_THP-1_Human1.46420482
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44463853
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.43269776
47RUNX_20019798_ChIP-Seq_JUKART_Human1.41427660
48* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39015863
49LXR_22292898_ChIP-Seq_THP-1_Human1.37891273
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.36885244
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36650813
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36568680
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.36063440
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34344836
55* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32873928
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31849904
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30208373
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29125482
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27012931
60* RACK7_27058665_Chip-Seq_MCF-7_Human1.25428739
61* KDM2B_26808549_Chip-Seq_DND41_Human1.25341449
62* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.24575127
63VDR_24763502_ChIP-Seq_THP-1_Human1.23474389
64* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22286237
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22258218
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.22076656
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21854816
68UTX_26944678_Chip-Seq_JUKART_Human1.20979460
69* MYB_26560356_Chip-Seq_TH1_Human1.20054417
70MYB_26560356_Chip-Seq_TH2_Human1.19528205
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17785513
72* FOXA2_19822575_ChIP-Seq_HepG2_Human1.16693825
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16458771
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15526186
75* SPI1_23547873_ChIP-Seq_NB4_Human1.14792638
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13530657
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13484914
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12787088
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12461560
80* SA1_27219007_Chip-Seq_ERYTHROID_Human1.12351579
81SCL_19346495_ChIP-Seq_HPC-7_Human1.10900173
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09147234
83* FOXO3_23340844_ChIP-Seq_DLD1_Human1.08752162
84ATF3_27146783_Chip-Seq_COLON_Human1.08311886
85E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07312630
86* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07072234
87* RUNX1_22412390_ChIP-Seq_EML_Mouse1.06057499
88GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05732180
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05399085
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04663388
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.04490263
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04391046
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04230874
94GATA6_25053715_ChIP-Seq_YYC3_Human1.03961336
95* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03163070
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02832104
97* GATA1_19941826_ChIP-Seq_K562_Human1.02832064
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02142169
99P68_20966046_ChIP-Seq_HELA_Human1.00739765
100P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00640209
101ZNF263_19887448_ChIP-Seq_K562_Human1.00397305
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00259789
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00142721
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99647938
105SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98011340
106* SMC4_20622854_ChIP-Seq_HELA_Human0.97686551
107GATA1_22025678_ChIP-Seq_K562_Human0.97198350
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.96919271
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96862847
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96275119
111* MAF_26560356_Chip-Seq_TH2_Human0.95106334
112* GATA2_19941826_ChIP-Seq_K562_Human0.94851742
113* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93771115
114GATA4_25053715_ChIP-Seq_YYC3_Human0.93362878
115P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93250410
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92383143
117TBX20_22328084_ChIP-Seq_HEART_Mouse0.92360013
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.92360013
119VDR_24787735_ChIP-Seq_THP-1_Human0.91688609
120* NCOR1_26117541_ChIP-Seq_K562_Human0.90972694
121PU_27001747_Chip-Seq_BMDM_Mouse0.88355039
122* HNF4A_19822575_ChIP-Seq_HepG2_Human0.87223832
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86696335
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.85217700
125FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.84911746
126* KDM2B_26808549_Chip-Seq_JURKAT_Human0.84554160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.92142630
2MP0005360_urolithiasis4.76122120
3MP0005365_abnormal_bile_salt3.67891724
4MP0005085_abnormal_gallbladder_physiolo3.57230180
5MP0009840_abnormal_foam_cell2.98939293
6MP0008875_abnormal_xenobiotic_pharmacok2.95804920
7MP0003252_abnormal_bile_duct2.78539486
8MP0003300_gastrointestinal_ulcer2.69150974
9MP0003705_abnormal_hypodermis_morpholog2.53547196
10MP0003436_decreased_susceptibility_to2.36292153
11MP0010329_abnormal_lipoprotein_level2.27425275
12MP0003806_abnormal_nucleotide_metabolis2.20707758
13MP0005083_abnormal_biliary_tract2.20358105
14MP0003303_peritoneal_inflammation2.19774257
15MP0003191_abnormal_cellular_cholesterol2.13511169
16MP0002138_abnormal_hepatobiliary_system2.10217888
17MP0003172_abnormal_lysosome_physiology2.07648703
18MP0000609_abnormal_liver_physiology1.89359870
19MP0008260_abnormal_autophagy1.83696932
20MP0001666_abnormal_nutrient_absorption1.72485535
21MP0004510_myositis1.71612156
22MP0005387_immune_system_phenotype1.70728058
23MP0001790_abnormal_immune_system1.70728058
24MP0005332_abnormal_amino_acid1.69530679
25MP0003828_pulmonary_edema1.64619383
26MP0003195_calcinosis1.61049884
27MP0003091_abnormal_cell_migration1.59401040
28MP0003724_increased_susceptibility_to1.55802118
29MP0000685_abnormal_immune_system1.54468657
30MP0004019_abnormal_vitamin_homeostasis1.49620349
31MP0005319_abnormal_enzyme/_coenzyme1.48947511
32MP0009785_altered_susceptibility_to1.46757234
33MP0004947_skin_inflammation1.45637804
34MP0002118_abnormal_lipid_homeostasis1.41504727
35MP0003075_altered_response_to1.39847294
36MP0006082_CNS_inflammation1.39604185
37MP0010155_abnormal_intestine_physiology1.38480280
38MP0001958_emphysema1.36456157
39MP0001853_heart_inflammation1.34774349
40MP0008469_abnormal_protein_level1.34399679
41MP0005025_abnormal_response_to1.33019742
42MP0001835_abnormal_antigen_presentation1.32784202
43MP0009764_decreased_sensitivity_to1.30132134
44MP0001800_abnormal_humoral_immune1.28698626
45MP0005409_darkened_coat_color1.27724765
46MP0005464_abnormal_platelet_physiology1.27416060
47MP0003566_abnormal_cell_adhesion1.26586728
48MP0008004_abnormal_stomach_pH1.26264710
49MP0005000_abnormal_immune_tolerance1.25114634
50MP0002419_abnormal_innate_immunity1.24882263
51MP0005451_abnormal_body_composition1.21808954
52MP0001845_abnormal_inflammatory_respons1.21312031
53MP0001851_eye_inflammation1.20013499
54MP0009643_abnormal_urine_homeostasis1.18447483
55MP0001533_abnormal_skeleton_physiology1.18089673
56MP0005076_abnormal_cell_differentiation1.17129787
57MP0000598_abnormal_liver_morphology1.16742464
58MP0010352_gastrointestinal_tract_polyps1.15743383
59MP0010234_abnormal_vibrissa_follicle1.14063670
60MP0002933_joint_inflammation1.13715812
61MP0002405_respiratory_system_inflammati1.13684455
62MP0005671_abnormal_response_to1.12250467
63MP0002723_abnormal_immune_serum1.10381142
64MP0000604_amyloidosis1.09513831
65MP0005584_abnormal_enzyme/coenzyme_acti1.09230718
66MP0003453_abnormal_keratinocyte_physiol1.07597236
67MP0002398_abnormal_bone_marrow1.05939034
68MP0009763_increased_sensitivity_to1.05904049
69MP0005058_abnormal_lysosome_morphology1.05816130
70MP0002254_reproductive_system_inflammat1.03985818
71MP0002452_abnormal_antigen_presenting1.03694202
72MP0008438_abnormal_cutaneous_collagen1.03299765
73MP0005023_abnormal_wound_healing1.02327540
74MP0004272_abnormal_basement_membrane1.02280725
75MP0002796_impaired_skin_barrier1.00097235
76MP0000767_abnormal_smooth_muscle0.99814053
77MP0003045_fibrosis0.98311296
78MP0003329_amyloid_beta_deposits0.98108511
79MP0009278_abnormal_bone_marrow0.97505064
80MP0004858_abnormal_nervous_system0.94531100
81MP0005164_abnormal_response_to0.93392281
82MP0001881_abnormal_mammary_gland0.93141055
83MP0002722_abnormal_immune_system0.91450509
84MP0002429_abnormal_blood_cell0.90626854
85MP0004185_abnormal_adipocyte_glucose0.89269681
86MP0003866_abnormal_defecation0.89076154
87MP0005310_abnormal_salivary_gland0.88986584
88MP0005390_skeleton_phenotype0.88939681
89MP0001873_stomach_inflammation0.88502636
90MP0009333_abnormal_splenocyte_physiolog0.87259650
91MP0002998_abnormal_bone_remodeling0.86719879
92MP0001819_abnormal_immune_cell0.86573861
93MP0002420_abnormal_adaptive_immunity0.86243319
94MP0005670_abnormal_white_adipose0.86186306
95MP0001915_intracranial_hemorrhage0.86081747
96MP0004808_abnormal_hematopoietic_stem0.84343771
97MP0008961_abnormal_basal_metabolism0.82550414
98MP0003868_abnormal_feces_composition0.81675729
99MP0005166_decreased_susceptibility_to0.81086772
100MP0003448_altered_tumor_morphology0.80921229
101MP0005375_adipose_tissue_phenotype0.80557547
102MP0010368_abnormal_lymphatic_system0.79951005
103MP0002166_altered_tumor_susceptibility0.79928350
104MP0002060_abnormal_skin_morphology0.79789210
105MP0002136_abnormal_kidney_physiology0.79750341
106MP0000343_altered_response_to0.78762773
107MP0002148_abnormal_hypersensitivity_rea0.77658105
108MP0001243_abnormal_dermal_layer0.77649317
109MP0003795_abnormal_bone_structure0.77312244
110MP0002168_other_aberrant_phenotype0.76756060
111MP0005397_hematopoietic_system_phenotyp0.76333911
112MP0001545_abnormal_hematopoietic_system0.76333911
113MP0004130_abnormal_muscle_cell0.76082025
114MP0005275_abnormal_skin_tensile0.73672246
115MP0001216_abnormal_epidermal_layer0.73552969
116MP0000249_abnormal_blood_vessel0.72609569
117MP0002877_abnormal_melanocyte_morpholog0.72168178
118MP0003279_aneurysm0.71731263
119MP0004782_abnormal_surfactant_physiolog0.71233433
120MP0009642_abnormal_blood_homeostasis0.70576937
121MP0000858_altered_metastatic_potential0.70027950
122MP0001849_ear_inflammation0.69932360
123MP0003656_abnormal_erythrocyte_physiolo0.69353118
124MP0005666_abnormal_adipose_tissue0.69107155
125MP0000689_abnormal_spleen_morphology0.68875021
126MP0000716_abnormal_immune_system0.68703142
127MP0000465_gastrointestinal_hemorrhage0.68284652
128MP0003763_abnormal_thymus_physiology0.67875742

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.33883844
2Xanthomatosis (HP:0000991)4.52952932
3Intrahepatic cholestasis (HP:0001406)4.33175673
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.29975257
5Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24752857
6Myocardial infarction (HP:0001658)4.02869886
7Abnormality of the common coagulation pathway (HP:0010990)3.78891978
8Complement deficiency (HP:0004431)3.74304903
9Joint hemorrhage (HP:0005261)3.68146694
10Prolonged partial thromboplastin time (HP:0003645)3.63485725
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.54861299
12Abnormality of macrophages (HP:0004311)3.39837617
13Hypobetalipoproteinemia (HP:0003563)3.39181605
14Hyperlipoproteinemia (HP:0010980)3.38946577
15Esophageal varix (HP:0002040)3.17434110
16Abnormality of sulfur amino acid metabolism (HP:0004339)3.10283168
17Abnormality of liposaccharide metabolism (HP:0010968)3.08582808
18Abnormality of glycosphingolipid metabolism (HP:0004343)3.08582808
19Abnormality of glycolipid metabolism (HP:0010969)3.08582808
20Abnormality of complement system (HP:0005339)3.03341475
21Hypoalphalipoproteinemia (HP:0003233)2.99088211
22Eczematoid dermatitis (HP:0000976)2.95699562
23Hypolipoproteinemia (HP:0010981)2.93373853
24Hyperammonemia (HP:0001987)2.92643117
25Epidermoid cyst (HP:0200040)2.92565040
26Recurrent gram-negative bacterial infections (HP:0005420)2.91418465
27Gingival bleeding (HP:0000225)2.83490238
28Dysostosis multiplex (HP:0000943)2.78890576
29Ketosis (HP:0001946)2.77992159
30Recurrent abscess formation (HP:0002722)2.71853976
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.71418454
32Peritonitis (HP:0002586)2.68465923
33Menorrhagia (HP:0000132)2.67960347
34Systemic lupus erythematosus (HP:0002725)2.67638133
35Hypoglycemic coma (HP:0001325)2.65072917
36Recurrent bacterial skin infections (HP:0005406)2.60260893
37Vacuolated lymphocytes (HP:0001922)2.59104145
38Hypercholesterolemia (HP:0003124)2.55190771
39Cerebral aneurysm (HP:0004944)2.52090048
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49581539
41Hyperglycinuria (HP:0003108)2.49278157
42Abnormality of the intrinsic pathway (HP:0010989)2.47351406
43Purpura (HP:0000979)2.45719354
44Fat malabsorption (HP:0002630)2.43587347
45Orchitis (HP:0100796)2.41988877
46Protrusio acetabuli (HP:0003179)2.41580701
47Abnormality of purine metabolism (HP:0004352)2.41519722
48Vertebral compression fractures (HP:0002953)2.41506274
49Increased cerebral lipofuscin (HP:0011813)2.41008935
50Mitral stenosis (HP:0001718)2.39309560
51Increased IgE level (HP:0003212)2.38687472
52Abnormality of nucleobase metabolism (HP:0010932)2.38425456
53Thrombophlebitis (HP:0004418)2.36645912
54Vascular calcification (HP:0004934)2.36172519
55Myositis (HP:0100614)2.36149970
56Abnormality of fatty-acid metabolism (HP:0004359)2.36050947
57Abnormality of polysaccharide metabolism (HP:0011012)2.35709694
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35709694
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35709694
60Polycythemia (HP:0001901)2.35597802
61Hydroxyprolinuria (HP:0003080)2.35152582
62Abnormality of proline metabolism (HP:0010907)2.35152582
63Premature rupture of membranes (HP:0001788)2.33709393
64Arterial thrombosis (HP:0004420)2.33153786
65Abnormality of pyrimidine metabolism (HP:0004353)2.32236925
66Increased mean platelet volume (HP:0011877)2.31988857
67Mucopolysacchariduria (HP:0008155)2.31234775
68Urinary glycosaminoglycan excretion (HP:0003541)2.31234775
69Hepatocellular carcinoma (HP:0001402)2.31208396
70Prolonged bleeding time (HP:0003010)2.28931685
71Pulmonary embolism (HP:0002204)2.28669813
72Gingivitis (HP:0000230)2.27048077
73Abnormal platelet volume (HP:0011876)2.26858414
74Abnormality of methionine metabolism (HP:0010901)2.25965674
75Abnormality of glycine metabolism (HP:0010895)2.25623761
76Abnormality of serine family amino acid metabolism (HP:0010894)2.25623761
77Cardiovascular calcification (HP:0011915)2.24504136
78Abnormality of iron homeostasis (HP:0011031)2.24129352
79Thin bony cortex (HP:0002753)2.23615621
80Increased density of long bones (HP:0006392)2.23379203
81Increased connective tissue (HP:0009025)2.20439871
82Gastrointestinal infarctions (HP:0005244)2.17733572
83Increased serum ferritin (HP:0003281)2.17244384
84Loss of speech (HP:0002371)2.16608958
85Abnormality of transition element cation homeostasis (HP:0011030)2.16291384
86Hyperglycinemia (HP:0002154)2.15715992
87Distal lower limb amyotrophy (HP:0008944)2.15465005
88Skin nodule (HP:0200036)2.13181652
89Gout (HP:0001997)2.12370505
90Impaired platelet aggregation (HP:0003540)2.11073705
91Abnormal platelet function (HP:0011869)2.11073705
92Recurrent fungal infections (HP:0002841)2.10146723
93Hemorrhage of the eye (HP:0011885)2.08460088
94Obstructive lung disease (HP:0006536)2.07153727
95Chronic obstructive pulmonary disease (HP:0006510)2.07153727
96Joint swelling (HP:0001386)2.06828593
97Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.06445224
98Ketoacidosis (HP:0001993)2.06188967
99Epistaxis (HP:0000421)2.06103769
100Distal lower limb muscle weakness (HP:0009053)2.03745014
101Broad face (HP:0000283)2.03714477
102Autoimmune thrombocytopenia (HP:0001973)2.03519599
103Cellulitis (HP:0100658)2.03501249
104Amyloidosis (HP:0011034)2.01640979
105Polygenic inheritance (HP:0010982)2.01007155
106Nephritis (HP:0000123)2.00574946
107Increased neuronal autofluorescent lipopigment (HP:0002074)1.99684777
108Glomerulonephritis (HP:0000099)1.99050048
109Pancreatitis (HP:0001733)1.96494904
110Persistence of primary teeth (HP:0006335)1.95741315
111Retrobulbar optic neuritis (HP:0100654)1.95640176
112Optic neuritis (HP:0100653)1.95640176
113Interstitial pulmonary disease (HP:0006530)1.94586027
114Spondylolisthesis (HP:0003302)1.92155837
115Alopecia of scalp (HP:0002293)1.91575683
116Increased variability in muscle fiber diameter (HP:0003557)1.91301523
117Spontaneous abortion (HP:0005268)1.90511244
118Petechiae (HP:0000967)1.89985391
119Axonal loss (HP:0003447)1.89849332
120Disproportionate tall stature (HP:0001519)1.89617984
121Spastic diplegia (HP:0001264)1.88887674
122Dilatation of the ascending aorta (HP:0005111)1.88286104
123Cervical subluxation (HP:0003308)1.87502331
124Aneurysm (HP:0002617)1.87086990
125Segmental peripheral demyelination/remyelination (HP:0003481)1.86699931
126Hyperbilirubinemia (HP:0002904)1.85715398
127Mediastinal lymphadenopathy (HP:0100721)1.85692770
128Abnormality of the Achilles tendon (HP:0005109)1.84078081
129Anorexia (HP:0002039)1.80574031
130Spontaneous hematomas (HP:0007420)1.80386262
131Osteolytic defects of the hand bones (HP:0009699)1.79695104
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.79695104
133Abnormality of skeletal muscle fiber size (HP:0012084)1.79407358
134Bone pain (HP:0002653)1.79126403
135Malnutrition (HP:0004395)1.78515582
136Obstructive sleep apnea (HP:0002870)1.78423145
137Periodontitis (HP:0000704)1.78362610
138Right ventricular cardiomyopathy (HP:0011663)1.77934276
139Pustule (HP:0200039)1.77742814
140Asymmetric septal hypertrophy (HP:0001670)1.77620141
141Meningitis (HP:0001287)1.76873807
142Cholelithiasis (HP:0001081)1.76639535
143Elevated erythrocyte sedimentation rate (HP:0003565)1.76450563
144Conjugated hyperbilirubinemia (HP:0002908)1.76022102
145Recurrent skin infections (HP:0001581)1.75088460
146Pulmonary infiltrates (HP:0002113)1.75058771
147Keratoconjunctivitis sicca (HP:0001097)1.75025170
148Mitral valve prolapse (HP:0001634)1.74559064
149Pathologic fracture (HP:0002756)1.74182092
150Hypertriglyceridemia (HP:0002155)1.73888950
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.73709262
152Thoracic kyphosis (HP:0002942)1.72783390
153Achilles tendon contracture (HP:0001771)1.71415850
154Neurofibrillary tangles (HP:0002185)1.71271132
155Cerebral inclusion bodies (HP:0100314)1.71256759
156Reticulocytosis (HP:0001923)1.71106024
157Vasculitis (HP:0002633)1.70945739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.02030355
2PRPF4B3.73716815
3ERN13.44646534
4PKN22.99709065
5MAP4K12.95022232
6FGFR42.89486205
7SIK12.83300679
8TAOK32.80003428
9EPHB12.42534873
10IRAK32.40635084
11TXK2.38329712
12JAK32.35891236
13MAP3K142.26698045
14RIPK42.17628903
15TBK12.08962408
16TYK22.08587215
17SMG12.04025923
18JAK11.94352482
19PTK61.92885892
20EPHA31.92735246
21BCKDK1.88757435
22TTN1.87917962
23MAP3K131.77562694
24EEF2K1.74147439
25ICK1.63808853
26ZAP701.63718934
27MAP3K101.49551984
28CDK121.37242250
29TGFBR21.36315024
30MAP2K31.35163225
31RIPK11.32671265
32STK101.31767264
33FES1.30849272
34BMX1.27561386
35JAK21.27151960
36KSR21.24645826
37MAP3K31.24574049
38FGFR31.23615469
39CHUK1.22387248
40IKBKE1.21901484
41CDC42BPA1.18995379
42MAP3K71.18152078
43CSK1.15174644
44IKBKB1.13656243
45NEK91.12560357
46ITK1.07006652
47CDK61.06772827
48MAP3K111.05113538
49LATS11.00440222
50PRKD20.99790168
51LRRK20.97438121
52MARK20.95403452
53PIM10.92730533
54ARAF0.92417428
55MST1R0.90036285
56HCK0.88579395
57RPS6KA20.88566853
58GRK60.87116634
59BLK0.86212989
60RPS6KA40.84545564
61CAMK1D0.84460288
62MAP3K60.81493130
63FLT30.81488819
64BTK0.81423223
65KIT0.80834723
66HIPK20.78880628
67SIK30.78856500
68FGR0.77616140
69MTOR0.75536844
70TAOK10.74523348
71PTK20.74054902
72TESK20.73896592
73ERBB40.73787697
74GSK3A0.72112543
75MOS0.71067300
76RPS6KC10.70669734
77RPS6KL10.70669734
78MAPK120.70643831
79KDR0.69888934
80TNK20.69810482
81TRPM70.69258242
82PIM20.69213465
83PDK10.69210033
84EPHA20.68306128
85MAPK70.66901281
86PRKG20.66847988
87NLK0.66039425
88PDGFRA0.65590192
89CDK40.65009919
90MAP3K20.63994720
91TESK10.63927515
92MAPK110.63548572
93IRAK20.63495928
94SGK30.62363272
95LCK0.60783777
96SIK20.60290610
97DMPK0.60055589
98DDR20.59576390
99TIE10.58698520
100STK30.58497264
101MAP3K10.57326583
102CAMK1G0.54898562
103TEC0.54185112
104PRKAA20.53727947
105MATK0.52555686
106PDGFRB0.51523658
107IRAK40.51134847
108PAK20.50726477
109ALK0.50590411
110PIK3CG0.49195179
111CSF1R0.47648491
112MAP3K50.47428691
113IRAK10.47020516
114LYN0.46738086
115RET0.45396059
116EGFR0.43456981
117PRKCH0.42824454
118TAOK20.42058369
119ABL20.41763641
120PAK40.41270510
121MARK30.41093559
122MAPK40.39976208
123DYRK1B0.39865257
124MAPKAPK20.39077679
125SYK0.39028788
126MAP3K80.38796906
127ABL10.38727255
128FGFR10.38620116
129PDPK10.36702448
130INSRR0.36368153
131RPS6KA60.35494925
132NME20.34305623
133STK240.34045477

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.44073626
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.04932533
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93136418
4Nitrogen metabolism_Homo sapiens_hsa009102.70037669
5Other glycan degradation_Homo sapiens_hsa005112.67039991
6Arginine biosynthesis_Homo sapiens_hsa002202.62941411
7Complement and coagulation cascades_Homo sapiens_hsa046102.44769762
8Tryptophan metabolism_Homo sapiens_hsa003802.35806310
9Staphylococcus aureus infection_Homo sapiens_hsa051502.29075532
10Fatty acid degradation_Homo sapiens_hsa000712.21398977
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01311154
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.93613252
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.93075929
14Asthma_Homo sapiens_hsa053101.89545051
15Caffeine metabolism_Homo sapiens_hsa002321.82173603
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.82081959
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79200007
18PPAR signaling pathway_Homo sapiens_hsa033201.75274949
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74729580
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67061383
21Prion diseases_Homo sapiens_hsa050201.56268746
22Peroxisome_Homo sapiens_hsa041461.49310314
23Fatty acid metabolism_Homo sapiens_hsa012121.47720578
24Lysosome_Homo sapiens_hsa041421.47103994
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43051738
26Selenocompound metabolism_Homo sapiens_hsa004501.39863934
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39603043
28beta-Alanine metabolism_Homo sapiens_hsa004101.39540915
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38799034
30Histidine metabolism_Homo sapiens_hsa003401.36151402
31Propanoate metabolism_Homo sapiens_hsa006401.35679360
32Butanoate metabolism_Homo sapiens_hsa006501.30646644
33Chemical carcinogenesis_Homo sapiens_hsa052041.30340800
34VEGF signaling pathway_Homo sapiens_hsa043701.30264262
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25769262
36Pancreatic cancer_Homo sapiens_hsa052121.25610189
37Bile secretion_Homo sapiens_hsa049761.25606619
38Lysine degradation_Homo sapiens_hsa003101.24652658
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.23268163
40Non-small cell lung cancer_Homo sapiens_hsa052231.21429676
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.21111939
42Starch and sucrose metabolism_Homo sapiens_hsa005001.20356670
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19967884
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.19472215
45Bladder cancer_Homo sapiens_hsa052191.19268817
46Fat digestion and absorption_Homo sapiens_hsa049751.18186691
47Retinol metabolism_Homo sapiens_hsa008301.16587806
48Allograft rejection_Homo sapiens_hsa053301.14236594
49Phenylalanine metabolism_Homo sapiens_hsa003601.11256103
50* Influenza A_Homo sapiens_hsa051641.10031120
51Renal cell carcinoma_Homo sapiens_hsa052111.08490455
52Notch signaling pathway_Homo sapiens_hsa043301.07121878
53ABC transporters_Homo sapiens_hsa020101.06834416
54Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06820719
55Hepatitis B_Homo sapiens_hsa051611.05806794
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.05445470
57Chemokine signaling pathway_Homo sapiens_hsa040621.04552636
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.00453025
59Leishmaniasis_Homo sapiens_hsa051400.99813469
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.99279526
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.96526962
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95660701
63Shigellosis_Homo sapiens_hsa051310.95539286
64Phagosome_Homo sapiens_hsa041450.94924009
65Platelet activation_Homo sapiens_hsa046110.93929481
66Vitamin digestion and absorption_Homo sapiens_hsa049770.93842132
67Salmonella infection_Homo sapiens_hsa051320.93338058
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.92414998
69Carbon metabolism_Homo sapiens_hsa012000.91790314
70Focal adhesion_Homo sapiens_hsa045100.90695152
71Osteoclast differentiation_Homo sapiens_hsa043800.90418005
72Biosynthesis of amino acids_Homo sapiens_hsa012300.90287322
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.90153816
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.89807910
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88381776
76Pyruvate metabolism_Homo sapiens_hsa006200.86675064
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86574681
78Measles_Homo sapiens_hsa051620.84759390
79Insulin resistance_Homo sapiens_hsa049310.84642109
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84406317
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.82742577
82Galactose metabolism_Homo sapiens_hsa000520.81085909
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78246031
84Endometrial cancer_Homo sapiens_hsa052130.76840413
85Toxoplasmosis_Homo sapiens_hsa051450.76721224
86TNF signaling pathway_Homo sapiens_hsa046680.76699152
87Tyrosine metabolism_Homo sapiens_hsa003500.76295890
88Acute myeloid leukemia_Homo sapiens_hsa052210.75401919
89African trypanosomiasis_Homo sapiens_hsa051430.75065000
90Herpes simplex infection_Homo sapiens_hsa051680.72547569
91Insulin signaling pathway_Homo sapiens_hsa049100.71909287
92Sulfur relay system_Homo sapiens_hsa041220.71870756
93Rheumatoid arthritis_Homo sapiens_hsa053230.71470509
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.71443213
95mTOR signaling pathway_Homo sapiens_hsa041500.71037906
96GnRH signaling pathway_Homo sapiens_hsa049120.70613550
97Arginine and proline metabolism_Homo sapiens_hsa003300.70431154
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.70071916
99Fructose and mannose metabolism_Homo sapiens_hsa000510.69661287
100Proteoglycans in cancer_Homo sapiens_hsa052050.69627393
101Sulfur metabolism_Homo sapiens_hsa009200.69476614
102Endocytosis_Homo sapiens_hsa041440.67973154
103Thyroid cancer_Homo sapiens_hsa052160.67371266
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67016813
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.65675242
106HIF-1 signaling pathway_Homo sapiens_hsa040660.64868726
107One carbon pool by folate_Homo sapiens_hsa006700.62695545
108Autoimmune thyroid disease_Homo sapiens_hsa053200.62216690
109Folate biosynthesis_Homo sapiens_hsa007900.61993178
110Prostate cancer_Homo sapiens_hsa052150.61874650
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61756701
112ECM-receptor interaction_Homo sapiens_hsa045120.61737534
113Glioma_Homo sapiens_hsa052140.61474099
114Antigen processing and presentation_Homo sapiens_hsa046120.60669360
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60549991
116Glycerolipid metabolism_Homo sapiens_hsa005610.59715458
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57260398
118Malaria_Homo sapiens_hsa051440.57156314
119FoxO signaling pathway_Homo sapiens_hsa040680.57063607
120Legionellosis_Homo sapiens_hsa051340.56913026
121ErbB signaling pathway_Homo sapiens_hsa040120.56458168
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55325183
123Chronic myeloid leukemia_Homo sapiens_hsa052200.55114886
124T cell receptor signaling pathway_Homo sapiens_hsa046600.54716546
125HTLV-I infection_Homo sapiens_hsa051660.54619986
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53219795
127Choline metabolism in cancer_Homo sapiens_hsa052310.52318505
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52283146
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51907653
130Amoebiasis_Homo sapiens_hsa051460.51772476
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50918550
132Type II diabetes mellitus_Homo sapiens_hsa049300.50527049
133Hematopoietic cell lineage_Homo sapiens_hsa046400.50031814
134Inositol phosphate metabolism_Homo sapiens_hsa005620.48906601
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48766293
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48165424
137Pentose phosphate pathway_Homo sapiens_hsa000300.47917014
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47701679
139Viral carcinogenesis_Homo sapiens_hsa052030.47281863
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46658138
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45777938
142Primary immunodeficiency_Homo sapiens_hsa053400.45647486
143Pertussis_Homo sapiens_hsa051330.44668721
144Apoptosis_Homo sapiens_hsa042100.44194295
145Graft-versus-host disease_Homo sapiens_hsa053320.43661912
146Prolactin signaling pathway_Homo sapiens_hsa049170.43332634
147Glutathione metabolism_Homo sapiens_hsa004800.41545434
148Small cell lung cancer_Homo sapiens_hsa052220.40386613
149B cell receptor signaling pathway_Homo sapiens_hsa046620.40055797
150Maturity onset diabetes of the young_Homo sapiens_hsa049500.39818609
151Viral myocarditis_Homo sapiens_hsa054160.39474494
152Fatty acid biosynthesis_Homo sapiens_hsa000610.39460325
153Hepatitis C_Homo sapiens_hsa051600.38725557
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38555439
155Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38450947
156Fatty acid elongation_Homo sapiens_hsa000620.38045314
157Tuberculosis_Homo sapiens_hsa051520.36387578
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.35976211
159Steroid biosynthesis_Homo sapiens_hsa001000.35595658

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