FUNDC2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.80235244
2microtubule depolymerization (GO:0007019)8.45461411
3sperm capacitation (GO:0048240)8.09808391
4single strand break repair (GO:0000012)8.02839779
5chromosome condensation (GO:0030261)7.93501784
6DNA packaging (GO:0006323)7.86431667
7spermatid development (GO:0007286)7.82084223
8plasma membrane fusion (GO:0045026)7.56677364
9spermatid nucleus differentiation (GO:0007289)7.26913695
10rRNA methylation (GO:0031167)7.03892976
11response to pheromone (GO:0019236)6.81475406
12protein polyglutamylation (GO:0018095)6.73149845
13multicellular organism reproduction (GO:0032504)6.67068394
14microtubule polymerization or depolymerization (GO:0031109)6.65363050
15sperm-egg recognition (GO:0035036)6.52785770
16rRNA modification (GO:0000154)6.38882541
17reproduction (GO:0000003)6.31427008
18axonemal dynein complex assembly (GO:0070286)6.29311098
19sexual reproduction (GO:0019953)6.20705562
20protein targeting to Golgi (GO:0000042)5.97247376
21calcium ion-dependent exocytosis (GO:0017156)5.73045281
22regulation of cilium movement (GO:0003352)5.72699014
23establishment of protein localization to Golgi (GO:0072600)5.72219252
24centriole replication (GO:0007099)5.64363325
25cellular ketone body metabolic process (GO:0046950)5.60173820
26spermatogenesis (GO:0007283)5.59672516
27microtubule severing (GO:0051013)5.59295407
28male gamete generation (GO:0048232)5.58371218
29RNA destabilization (GO:0050779)5.58228308
30binding of sperm to zona pellucida (GO:0007339)5.56401022
31retrograde transport, vesicle recycling within Golgi (GO:0000301)5.50928681
32phosphatidylethanolamine biosynthetic process (GO:0006646)5.49198789
33cell-cell recognition (GO:0009988)5.30346406
34phosphatidylethanolamine metabolic process (GO:0046337)5.21662509
35gamete generation (GO:0007276)5.14495226
36negative regulation of inclusion body assembly (GO:0090084)5.13262436
37ketone body metabolic process (GO:1902224)4.93709598
38epithelial cilium movement (GO:0003351)4.93447444
39cilium or flagellum-dependent cell motility (GO:0001539)4.83712694
40centriole assembly (GO:0098534)4.83426754
41cell wall macromolecule metabolic process (GO:0044036)4.72651795
42single fertilization (GO:0007338)4.63156193
43motile cilium assembly (GO:0044458)4.37295810
44regulation of microtubule-based movement (GO:0060632)4.34668508
45protein localization to Golgi apparatus (GO:0034067)4.32557605
46regulation of transcription involved in cell fate commitment (GO:0060850)4.30835065
47germ cell development (GO:0007281)4.30731689
48cilium movement (GO:0003341)4.25031929
49cell wall macromolecule catabolic process (GO:0016998)4.23654997
50multicellular organismal reproductive process (GO:0048609)4.08959377
51regulation of centriole replication (GO:0046599)4.07673722
52piRNA metabolic process (GO:0034587)4.02976338
53regulation of Rab GTPase activity (GO:0032313)4.01028517
54positive regulation of Rab GTPase activity (GO:0032851)4.01028517
55cellular process involved in reproduction in multicellular organism (GO:0022412)3.97125925
56seminiferous tubule development (GO:0072520)3.97081177
57epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88606875
58fertilization (GO:0009566)3.86006688
59polyamine biosynthetic process (GO:0006596)3.81819708
60organic cation transport (GO:0015695)3.76322268
61regulation of inclusion body assembly (GO:0090083)3.66143212
62DNA methylation involved in gamete generation (GO:0043046)3.56136165
63musculoskeletal movement (GO:0050881)3.49147443
64multicellular organismal movement (GO:0050879)3.49147443
65sequestering of actin monomers (GO:0042989)3.38341530
66glycerol ether metabolic process (GO:0006662)3.32387460
67regulation of interleukin-13 production (GO:0032656)3.23928828
68nucleus organization (GO:0006997)3.23109452
69histone exchange (GO:0043486)3.18868498
70microtubule nucleation (GO:0007020)3.13422659
71response to acidic pH (GO:0010447)3.11355219
72ether metabolic process (GO:0018904)3.10083276
73male meiosis (GO:0007140)3.08419134
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.07579830
75coenzyme catabolic process (GO:0009109)3.06312781
76regulation of somitogenesis (GO:0014807)3.04552746
77male meiosis I (GO:0007141)3.04492456
78chromatin silencing (GO:0006342)2.99702619
79multicellular organismal development (GO:0007275)2.97627005
80protein neddylation (GO:0045116)2.94582493
81positive regulation of endothelial cell differentiation (GO:0045603)2.93316964
82cellular response to pH (GO:0071467)2.93074009
83negative regulation of Rho protein signal transduction (GO:0035024)2.90510794
84spinal cord motor neuron differentiation (GO:0021522)2.86658722
85regulation of meiosis I (GO:0060631)2.79027866
86membrane protein intracellular domain proteolysis (GO:0031293)2.77056137
87pattern specification involved in kidney development (GO:0061004)2.75257819
88cell recognition (GO:0008037)2.72923084
89mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72084192
90regulation of phosphoprotein phosphatase activity (GO:0043666)2.68925265
91cerebral cortex neuron differentiation (GO:0021895)2.68578992
92cellular biogenic amine biosynthetic process (GO:0042401)2.67786285
93axoneme assembly (GO:0035082)2.67536706
94negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.63116292
95positive regulation of guanylate cyclase activity (GO:0031284)2.59434907
96cranial nerve morphogenesis (GO:0021602)2.59144623
97somite rostral/caudal axis specification (GO:0032525)2.58186554
98meiosis I (GO:0007127)2.58118081
99sperm motility (GO:0030317)11.2072024
100acrosome reaction (GO:0007340)10.3445219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.71712615
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.19352988
3EZH2_22144423_ChIP-Seq_EOC_Human3.84337528
4POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.49694680
5TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.49694680
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39662067
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.37332653
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35724691
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.24273365
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19987944
11VDR_22108803_ChIP-Seq_LS180_Human2.17819251
12FUS_26573619_Chip-Seq_HEK293_Human2.14775572
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.08089769
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.00254008
15ER_23166858_ChIP-Seq_MCF-7_Human1.94468968
16TAF15_26573619_Chip-Seq_HEK293_Human1.91997491
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91284540
18CBP_20019798_ChIP-Seq_JUKART_Human1.90469711
19IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.90469711
20ERA_21632823_ChIP-Seq_H3396_Human1.83932736
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77715462
22P300_19829295_ChIP-Seq_ESCs_Human1.72191623
23TAF2_19829295_ChIP-Seq_ESCs_Human1.71873596
24AR_25329375_ChIP-Seq_VCAP_Human1.65950846
25NANOG_20526341_ChIP-Seq_ESCs_Human1.64928065
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63083922
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62406522
28EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.61002131
29ERG_20517297_ChIP-Seq_VCAP_Human1.59335032
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.59329613
31RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.58206111
32EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.54354202
33ZNF274_21170338_ChIP-Seq_K562_Hela1.51860981
34RAC3_21632823_ChIP-Seq_H3396_Human1.48650350
35TDRD3_21172665_ChIP-Seq_MCF-7_Human1.47747953
36MYC_19829295_ChIP-Seq_ESCs_Human1.46829360
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.46296974
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.43813702
39GBX2_23144817_ChIP-Seq_PC3_Human1.43674833
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43177533
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43118475
42ELF1_20517297_ChIP-Seq_JURKAT_Human1.39770635
43* RBPJ_21746931_ChIP-Seq_IB4_Human1.39710975
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39003467
45SOX2_19829295_ChIP-Seq_ESCs_Human1.37711768
46NANOG_19829295_ChIP-Seq_ESCs_Human1.37711768
47CBX2_22325352_ChIP-Seq_293T-Rex_Human1.37499429
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36714555
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.36714555
50OCT4_20526341_ChIP-Seq_ESCs_Human1.36203559
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36017545
52* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35837703
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.35821522
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.34554012
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33942231
56DROSHA_22980978_ChIP-Seq_HELA_Human1.33600259
57* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31798754
58CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.28144381
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.27815902
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.26480266
61* ETV1_20927104_ChIP-Seq_GIST48_Human1.26305338
62SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26247122
63CTCF_27219007_Chip-Seq_Bcells_Human1.23949452
64E2F1_20622854_ChIP-Seq_HELA_Human1.23795174
65BCL6_27268052_Chip-Seq_Bcells_Human1.23219355
66* YY1_22570637_ChIP-Seq_MALME-3M_Human1.22587690
67KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.22181700
68SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19778119
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19702550
70SMAD3_21741376_ChIP-Seq_ESCs_Human1.19183007
71SMAD4_21799915_ChIP-Seq_A2780_Human1.19027229
72CEBPB_22108803_ChIP-Seq_LS180_Human1.17641066
73CTCF_20526341_ChIP-Seq_ESCs_Human1.17224220
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16422783
75NFYB_21822215_ChIP-Seq_K562_Human1.15755449
76P300_27268052_Chip-Seq_Bcells_Human1.15567445
77PHF8_20622853_ChIP-Seq_HELA_Human1.15134692
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.14759236
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.13265298
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11761447
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.10743353
82* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10713940
83P53_21459846_ChIP-Seq_SAOS-2_Human1.10211112
84SALL4_22934838_ChIP-ChIP_CD34+_Human1.09009086
85REST_21632747_ChIP-Seq_MESCs_Mouse1.08485065
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07880791
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.07064642
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.05642154
89FOXH1_21741376_ChIP-Seq_EPCs_Human1.05578011
90STAT3_23295773_ChIP-Seq_U87_Human1.05291157
91TBL1_22424771_ChIP-Seq_293T_Human1.04642555
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.04197446
93RUNX1_26923725_Chip-Seq_HPCs_Mouse1.03318641
94NFYA_21822215_ChIP-Seq_K562_Human1.03038634
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.03037412
96* PHF8_20622854_ChIP-Seq_HELA_Human1.01936929
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01629277
98NCOR_22424771_ChIP-Seq_293T_Human1.00846975
99RNF2_27304074_Chip-Seq_NSC_Mouse1.00531276
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99927361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology4.22131280
2MP0005377_hearing/vestibular/ear_phenot4.22131280
3MP0003698_abnormal_male_reproductive3.94973488
4MP0005670_abnormal_white_adipose3.74783456
5MP0001929_abnormal_gametogenesis3.50362370
6MP0002822_catalepsy2.68556903
7MP0003718_maternal_effect2.54654406
8MP0003011_delayed_dark_adaptation2.34819154
9MP0001348_abnormal_lacrimal_gland2.33048092
10MP0002161_abnormal_fertility/fecundity2.21035241
11MP0005410_abnormal_fertilization10.3268120
12MP0009379_abnormal_foot_pigmentation1.94872397
13MP0000566_synostosis1.94231621
14MP0003646_muscle_fatigue1.83289033
15MP0002210_abnormal_sex_determination1.81718664
16MP0001968_abnormal_touch/_nociception1.78984436
17MP0002234_abnormal_pharynx_morphology1.73778362
18MP0001485_abnormal_pinna_reflex1.65145615
19MP0002735_abnormal_chemical_nociception1.60280849
20MP0002653_abnormal_ependyma_morphology1.50335182
21MP0005423_abnormal_somatic_nervous1.50258921
22MP0008877_abnormal_DNA_methylation1.46834001
23MP0000653_abnormal_sex_gland1.45603687
24MP0001145_abnormal_male_reproductive1.42362883
25MP0001486_abnormal_startle_reflex1.40853383
26MP0002736_abnormal_nociception_after1.38042732
27MP0002132_abnormal_respiratory_system1.36481971
28MP0005551_abnormal_eye_electrophysiolog1.35460888
29MP0002282_abnormal_trachea_morphology1.32854032
30MP0009053_abnormal_anal_canal1.32616248
31MP0004742_abnormal_vestibular_system1.30910554
32MP0005084_abnormal_gallbladder_morpholo1.27827442
33MP0000678_abnormal_parathyroid_gland1.25053186
34MP0001905_abnormal_dopamine_level1.22956610
35MP0009697_abnormal_copulation1.20124133
36MP0003283_abnormal_digestive_organ1.18195601
37MP0004859_abnormal_synaptic_plasticity1.15106194
38MP0005379_endocrine/exocrine_gland_phen1.13788627
39MP0001765_abnormal_ion_homeostasis1.10935210
40MP0005646_abnormal_pituitary_gland1.08666906
41MP0001963_abnormal_hearing_physiology1.07866291
42MP0005310_abnormal_salivary_gland1.06949610
43MP0002138_abnormal_hepatobiliary_system1.06715173
44MP0000026_abnormal_inner_ear1.06690665
45MP0005253_abnormal_eye_physiology1.06582029
46MP0005645_abnormal_hypothalamus_physiol1.04979925
47MP0009745_abnormal_behavioral_response1.04887063
48MP0002928_abnormal_bile_duct1.03663698
49MP0002249_abnormal_larynx_morphology0.99974541
50MP0002272_abnormal_nervous_system0.99189103
51MP0004142_abnormal_muscle_tone0.98989479
52MP0003880_abnormal_central_pattern0.98963673
53MP0006292_abnormal_olfactory_placode0.98516015
54MP0002067_abnormal_sensory_capabilities0.96992586
55MP0005636_abnormal_mineral_homeostasis0.92630618
56MP0003879_abnormal_hair_cell0.91156895
57MP0005395_other_phenotype0.90917527
58MP0002733_abnormal_thermal_nociception0.86150893
59MP0008995_early_reproductive_senescence0.85543850
60MP0010386_abnormal_urinary_bladder0.82950671
61MP0002229_neurodegeneration0.82802862
62MP0006276_abnormal_autonomic_nervous0.82601717
63MP0000516_abnormal_urinary_system0.79624994
64MP0005367_renal/urinary_system_phenotyp0.79624994
65MP0002557_abnormal_social/conspecific_i0.79442550
66MP0004085_abnormal_heartbeat0.78161771
67MP0000049_abnormal_middle_ear0.77728130
68MP0000955_abnormal_spinal_cord0.77009153
69MP0002572_abnormal_emotion/affect_behav0.76788123
70MP0000534_abnormal_ureter_morphology0.76036120
71MP0001529_abnormal_vocalization0.75958341
72MP0002102_abnormal_ear_morphology0.74209425
73MP0005408_hypopigmentation0.72318478
74MP0009764_decreased_sensitivity_to0.71859697
75MP0001879_abnormal_lymphatic_vessel0.69921012
76MP0008789_abnormal_olfactory_epithelium0.68317998
77MP0001501_abnormal_sleep_pattern0.67889012
78MP0008569_lethality_at_weaning0.67384406
79MP0000230_abnormal_systemic_arterial0.67213324
80MP0001970_abnormal_pain_threshold0.67096933
81MP0001666_abnormal_nutrient_absorption0.66565061
82MP0001984_abnormal_olfaction0.66557779
83MP0000631_abnormal_neuroendocrine_gland0.64050835
84MP0009046_muscle_twitch0.63913042
85MP0001440_abnormal_grooming_behavior0.63798833
86MP0002734_abnormal_mechanical_nocicepti0.63690494
87MP0004510_myositis0.62905077
88MP0001188_hyperpigmentation0.62308359
89MP0005167_abnormal_blood-brain_barrier0.57832354
90MP0002064_seizures0.57701199
91MP0008872_abnormal_physiological_respon0.56995394
92MP0003119_abnormal_digestive_system0.56786974
93MP0001293_anophthalmia0.55004283
94MP0006072_abnormal_retinal_apoptosis0.53655182
95MP0000372_irregular_coat_pigmentation0.53101322
96MP0008875_abnormal_xenobiotic_pharmacok0.50825898
97MP0002938_white_spotting0.49743673
98MP0005464_abnormal_platelet_physiology0.49080393
99MP0008961_abnormal_basal_metabolism0.48345534
100MP0003137_abnormal_impulse_conducting0.47698886

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)5.91277335
2Absent/shortened dynein arms (HP:0200106)5.68255070
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.68255070
4Abnormal ciliary motility (HP:0012262)4.62000086
5Abnormal respiratory motile cilium physiology (HP:0012261)4.51984419
6Abnormal respiratory epithelium morphology (HP:0012253)4.48343286
7Abnormal respiratory motile cilium morphology (HP:0005938)4.48343286
8Chronic hepatic failure (HP:0100626)4.41686549
9Attenuation of retinal blood vessels (HP:0007843)4.16175116
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.07255772
11Bony spicule pigmentary retinopathy (HP:0007737)3.90371130
12Renal Fanconi syndrome (HP:0001994)3.87514718
13Infertility (HP:0000789)3.66975248
14Potter facies (HP:0002009)3.62504819
15Facial shape deformation (HP:0011334)3.62504819
16Tubulointerstitial nephritis (HP:0001970)3.52111749
17Enlarged epiphyses (HP:0010580)3.41560915
18Abnormality of macular pigmentation (HP:0008002)3.37352441
19Generalized aminoaciduria (HP:0002909)3.35864907
20Abnormal rod and cone electroretinograms (HP:0008323)3.20151356
21Nasal polyposis (HP:0100582)3.18321540
22Male infertility (HP:0003251)3.14039377
23Nephronophthisis (HP:0000090)3.03443594
24Abnormal spermatogenesis (HP:0008669)3.03256892
25Rhinitis (HP:0012384)2.98687770
26Hyperkalemia (HP:0002153)2.97683549
27Asymmetric septal hypertrophy (HP:0001670)2.97423580
28Abnormality of renal resorption (HP:0011038)2.88118046
29Impulsivity (HP:0100710)2.87112614
30Cone-rod dystrophy (HP:0000548)2.82721534
31Optic nerve hypoplasia (HP:0000609)2.77585306
32Myokymia (HP:0002411)2.68856646
33Azoospermia (HP:0000027)2.65826197
34Bell-shaped thorax (HP:0001591)2.61080537
35Progressive cerebellar ataxia (HP:0002073)2.60982406
36Osteomalacia (HP:0002749)2.60133692
37Abnormal urine output (HP:0012590)2.55946746
38Renal dysplasia (HP:0000110)2.54768958
39Abnormality of urine glucose concentration (HP:0011016)2.53113260
40Glycosuria (HP:0003076)2.53113260
41Abnormality of the renal medulla (HP:0100957)2.51637036
42Pancreatic cysts (HP:0001737)2.49164542
43Aplasia/Hypoplasia of the earlobes (HP:0009906)2.48277708
44Resting tremor (HP:0002322)2.47794164
45Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46766148
46Hypoplastic ischia (HP:0003175)2.43931915
47Pendular nystagmus (HP:0012043)2.36940810
48Abnormality of the nasal mucosa (HP:0000433)2.36710409
49Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.35598166
50Abnormal drinking behavior (HP:0030082)2.35271748
51Polydipsia (HP:0001959)2.35271748
52Type II lissencephaly (HP:0007260)2.32917440
53Unilateral renal agenesis (HP:0000122)2.27971552
54Exertional dyspnea (HP:0002875)2.24460779
55Amelogenesis imperfecta (HP:0000705)2.23702207
56Polyuria (HP:0000103)2.23401233
57Progressive sensorineural hearing impairment (HP:0000408)2.19941526
58Postural instability (HP:0002172)2.19423026
59Portal hypertension (HP:0001409)2.19151668
60Abnormality of renal excretion (HP:0011036)2.18751125
61Chronic bronchitis (HP:0004469)2.17948684
62Pancreatic fibrosis (HP:0100732)2.17587077
63Hypophosphatemic rickets (HP:0004912)2.14691291
64Tubulointerstitial abnormality (HP:0001969)2.12363535
653-Methylglutaconic aciduria (HP:0003535)2.12295469
66Abnormality of lateral ventricle (HP:0030047)2.08623629
67Bronchiectasis (HP:0002110)2.07631502
68Stage 5 chronic kidney disease (HP:0003774)2.07253743
69Decreased central vision (HP:0007663)2.04594987
70Recurrent corneal erosions (HP:0000495)2.02559748
71Optic disc pallor (HP:0000543)2.02408207
72Esophageal atresia (HP:0002032)2.02397282
73Acute necrotizing encephalopathy (HP:0006965)2.02290278
74Abnormality of potassium homeostasis (HP:0011042)2.02071879
75Abnormality of the costochondral junction (HP:0000919)2.01493957
76Abnormality of dental color (HP:0011073)1.99892999
77Abnormal pupillary function (HP:0007686)1.98505989
78Abnormality of the ischium (HP:0003174)1.98401060
79Abnormality of the hepatic vasculature (HP:0006707)1.97541592
80Menstrual irregularities (HP:0000858)1.94908175
81Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92462545
82Increased hepatocellular lipid droplets (HP:0006565)1.92238625
83Hypoplasia of the thymus (HP:0000778)1.91786558
84Congenital, generalized hypertrichosis (HP:0004540)1.89977981
85Cerebellar dysplasia (HP:0007033)1.89326589
86Truncal obesity (HP:0001956)1.85811939
87Gastrointestinal atresia (HP:0002589)1.85099578
88Tubular atrophy (HP:0000092)1.83848798
89Hypoalphalipoproteinemia (HP:0003233)1.82445857
90Mitochondrial inheritance (HP:0001427)1.80867005
91Lipid accumulation in hepatocytes (HP:0006561)1.79323511
92Tetany (HP:0001281)1.76457570
93Absent thumb (HP:0009777)1.74125211
94Hyperphosphaturia (HP:0003109)1.73049999
95Bulbous nose (HP:0000414)1.72698270
96Median cleft lip (HP:0000161)1.70860565
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70814863
98Abnormal mitochondria in muscle tissue (HP:0008316)1.70752657
99Acute encephalopathy (HP:0006846)1.70424056
100Upper limb muscle weakness (HP:0003484)1.68472005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK47.47491060
2TESK14.73611887
3PNCK3.50824992
4DDR23.23850703
5PLK23.05190416
6MAP4K23.03970214
7INSRR2.97102483
8STK382.62884219
9STK38L2.56416263
10MAPK152.42280592
11ZAK2.24765466
12FRK1.87810519
13CAMK1G1.84843506
14TLK11.82588830
15PRKD31.44423134
16FGFR21.40834126
17PIK3CG1.40295938
18VRK21.30017080
19BRD41.26902475
20VRK11.23739496
21CDK71.18635604
22ACVR1B1.15824722
23WNK11.15384865
24ADRBK21.14716089
25WNK41.11396661
26SIK21.08884027
27PDK11.08187344
28NUAK11.05976988
29PDPK11.05725340
30NEK61.04910864
31TIE10.99933527
32BMPR1B0.97878802
33PTK2B0.93530485
34STK390.91836528
35PRKG10.89329025
36WNK30.89115153
37TESK20.88134430
38DYRK1B0.86014844
39PRKCG0.83867467
40DYRK20.80217557
41MAP3K90.79818642
42TXK0.79544081
43PINK10.78598622
44GRK10.75769569
45SRPK10.73704625
46NME10.70330320
47AKT30.70062559
48TRIM280.68258693
49GRK70.64789128
50MARK10.62453259
51TYRO30.61696163
52TAOK30.59601336
53TAF10.57821263
54BRSK20.57687246
55MINK10.56956859
56NEK20.56550394
57TNIK0.56135496
58MAP3K110.54086311
59TEC0.52414090
60UHMK10.50731516
61RIPK40.49300808
62PHKG10.48488067
63PHKG20.48488067
64PRKG20.47990455
65MST1R0.46258589
66CAMK10.45649281
67MKNK20.45629397
68MAP3K40.43913600
69RPS6KA10.43716632
70PLK30.42561969
71PAK30.41445681
72SGK2230.41217489
73SGK4940.41217489
74KSR20.40347715
75MAP2K20.39468670
76MAPK130.38935222
77CCNB10.38505878
78BRAF0.38168691
79PRKACA0.37781096
80CDK30.36815768
81PRKCZ0.36763580
82PRKAA20.35715787
83OXSR10.35127592
84PRKCB0.34087945
85NTRK30.34036345
86CDK10.33974813
87MYLK0.33742126
88DYRK30.33327709
89PRKCE0.33065496
90MUSK0.33000017
91SYK0.32946313
92STK160.32328004
93ADRBK10.32027831
94SGK10.31745688
95ROCK10.31640670
96PRKACB0.31289526
97MAP3K120.31120178
98GRK50.29720068
99GSK3B0.28917088
100PKN10.27862600

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.30300995
2Fatty acid biosynthesis_Homo sapiens_hsa000615.05670237
3Oxidative phosphorylation_Homo sapiens_hsa001903.21256686
4Olfactory transduction_Homo sapiens_hsa047402.86974248
5Butanoate metabolism_Homo sapiens_hsa006502.63003224
6Parkinsons disease_Homo sapiens_hsa050122.60256633
7Cardiac muscle contraction_Homo sapiens_hsa042602.51469654
8Huntingtons disease_Homo sapiens_hsa050162.42569786
9Phototransduction_Homo sapiens_hsa047442.30586621
10Ribosome_Homo sapiens_hsa030102.17803979
11Nitrogen metabolism_Homo sapiens_hsa009101.80218366
12Alzheimers disease_Homo sapiens_hsa050101.72556727
13Type I diabetes mellitus_Homo sapiens_hsa049401.58313188
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48226350
15Autoimmune thyroid disease_Homo sapiens_hsa053201.47070816
16Allograft rejection_Homo sapiens_hsa053301.46437835
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.45910506
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.45864681
19Taste transduction_Homo sapiens_hsa047421.38507346
20RNA polymerase_Homo sapiens_hsa030201.31315275
21RNA transport_Homo sapiens_hsa030131.27698711
22Graft-versus-host disease_Homo sapiens_hsa053321.24218526
23Fanconi anemia pathway_Homo sapiens_hsa034601.21381091
24Basal transcription factors_Homo sapiens_hsa030221.19329089
25Nicotine addiction_Homo sapiens_hsa050331.17308837
26Collecting duct acid secretion_Homo sapiens_hsa049661.16347562
27Asthma_Homo sapiens_hsa053101.13304760
28Fatty acid degradation_Homo sapiens_hsa000711.12876001
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.09929898
30Purine metabolism_Homo sapiens_hsa002301.08900774
31Proteasome_Homo sapiens_hsa030501.07734741
32Morphine addiction_Homo sapiens_hsa050321.04971840
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.04134883
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.00720906
35Serotonergic synapse_Homo sapiens_hsa047261.00210622
36Protein export_Homo sapiens_hsa030600.98715549
37Antigen processing and presentation_Homo sapiens_hsa046120.98225764
38Dorso-ventral axis formation_Homo sapiens_hsa043200.97712494
39Circadian entrainment_Homo sapiens_hsa047130.96065906
40Linoleic acid metabolism_Homo sapiens_hsa005910.95446043
41Fatty acid metabolism_Homo sapiens_hsa012120.90618632
42Glycerolipid metabolism_Homo sapiens_hsa005610.87964910
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.87601660
44Synaptic vesicle cycle_Homo sapiens_hsa047210.85477196
45Arginine and proline metabolism_Homo sapiens_hsa003300.82467976
46Oocyte meiosis_Homo sapiens_hsa041140.81816058
47Fat digestion and absorption_Homo sapiens_hsa049750.80991764
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78179206
49Salivary secretion_Homo sapiens_hsa049700.78002327
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77655655
51Homologous recombination_Homo sapiens_hsa034400.77440940
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70600999
53Calcium signaling pathway_Homo sapiens_hsa040200.69988210
54Caffeine metabolism_Homo sapiens_hsa002320.69598829
55Glutamatergic synapse_Homo sapiens_hsa047240.68678251
56Retinol metabolism_Homo sapiens_hsa008300.67915038
57Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67032541
58Hedgehog signaling pathway_Homo sapiens_hsa043400.66424445
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65828621
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65712569
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65458797
62GABAergic synapse_Homo sapiens_hsa047270.64282446
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60533850
64Metabolic pathways_Homo sapiens_hsa011000.59612007
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59439348
66Tyrosine metabolism_Homo sapiens_hsa003500.57325652
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55958496
68Protein digestion and absorption_Homo sapiens_hsa049740.54735955
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54550832
70Renin-angiotensin system_Homo sapiens_hsa046140.51615588
71Alcoholism_Homo sapiens_hsa050340.51505921
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.51256646
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50974886
74Systemic lupus erythematosus_Homo sapiens_hsa053220.49849414
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.48785247
76Peroxisome_Homo sapiens_hsa041460.46759524
77Chemical carcinogenesis_Homo sapiens_hsa052040.46384144
78Mismatch repair_Homo sapiens_hsa034300.45965355
79PPAR signaling pathway_Homo sapiens_hsa033200.45369319
80Phenylalanine metabolism_Homo sapiens_hsa003600.44717085
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44158549
82cAMP signaling pathway_Homo sapiens_hsa040240.43416734
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42229189
84ABC transporters_Homo sapiens_hsa020100.42169075
85Tryptophan metabolism_Homo sapiens_hsa003800.41833819
86Type II diabetes mellitus_Homo sapiens_hsa049300.40288847
87Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40173800
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39988049
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39706821
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.36866945
91Pyrimidine metabolism_Homo sapiens_hsa002400.36630403
92Regulation of autophagy_Homo sapiens_hsa041400.36253122
93Selenocompound metabolism_Homo sapiens_hsa004500.33504557
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32604827
95Nucleotide excision repair_Homo sapiens_hsa034200.32562599
96Renin secretion_Homo sapiens_hsa049240.32541479
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29500472
98Arachidonic acid metabolism_Homo sapiens_hsa005900.28979269
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28642618
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27460767

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »