FTO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.43094631
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21171502
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83395360
4synaptic vesicle docking involved in exocytosis (GO:0016081)4.80348731
5locomotory exploration behavior (GO:0035641)4.71402692
6synaptic vesicle exocytosis (GO:0016079)4.68127951
7vocalization behavior (GO:0071625)4.60973882
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.60335787
9glutamate secretion (GO:0014047)4.58038707
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.48536885
11regulation of synaptic vesicle exocytosis (GO:2000300)4.44906299
12response to pheromone (GO:0019236)4.44573500
13behavioral response to nicotine (GO:0035095)4.40851133
14regulation of glutamate receptor signaling pathway (GO:1900449)4.34378945
15regulation of synapse structural plasticity (GO:0051823)4.16253042
16neurotransmitter secretion (GO:0007269)4.12456832
17regulation of synaptic vesicle transport (GO:1902803)4.05719505
18layer formation in cerebral cortex (GO:0021819)4.04513364
19cilium or flagellum-dependent cell motility (GO:0001539)4.02360634
20positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91710073
21positive regulation of synapse maturation (GO:0090129)3.84506423
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84169325
23kynurenine metabolic process (GO:0070189)3.84033128
24neuron cell-cell adhesion (GO:0007158)3.81828423
25regulation of pigment cell differentiation (GO:0050932)3.81180149
26protein localization to synapse (GO:0035418)3.78073998
27regulation of neuronal synaptic plasticity (GO:0048168)3.77113602
28indole-containing compound catabolic process (GO:0042436)3.71660648
29indolalkylamine catabolic process (GO:0046218)3.71660648
30tryptophan catabolic process (GO:0006569)3.71660648
31gamma-aminobutyric acid transport (GO:0015812)3.69021611
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.65587815
33cell migration in hindbrain (GO:0021535)3.65494195
34regulation of hippo signaling (GO:0035330)3.65382362
35exploration behavior (GO:0035640)3.64506942
36dendritic spine morphogenesis (GO:0060997)3.63273101
37cerebellar Purkinje cell differentiation (GO:0021702)3.61259537
38auditory behavior (GO:0031223)3.59456410
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.55789266
40fucose catabolic process (GO:0019317)3.54773961
41L-fucose metabolic process (GO:0042354)3.54773961
42L-fucose catabolic process (GO:0042355)3.54773961
43positive regulation of developmental pigmentation (GO:0048087)3.54407489
44axonal fasciculation (GO:0007413)3.51253337
45cell communication by electrical coupling (GO:0010644)3.50638308
46interkinetic nuclear migration (GO:0022027)3.49792190
47negative regulation of sodium ion transport (GO:0010766)3.48578784
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.47212153
49cellular potassium ion homeostasis (GO:0030007)3.46800088
50dendrite morphogenesis (GO:0048813)3.44942757
51neuron recognition (GO:0008038)3.42424203
52neuronal action potential propagation (GO:0019227)3.42079899
53activation of protein kinase A activity (GO:0034199)3.40986118
54proline transport (GO:0015824)3.38347332
55neurotransmitter-gated ion channel clustering (GO:0072578)3.38032369
56sodium ion export (GO:0071436)3.36625080
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36521125
58establishment of nucleus localization (GO:0040023)3.36376254
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34505468
60synaptic vesicle endocytosis (GO:0048488)3.34425586
61indolalkylamine metabolic process (GO:0006586)3.34403537
62neural tube formation (GO:0001841)3.30846025
63synaptic transmission, glutamatergic (GO:0035249)3.29124190
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.28946089
65negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.28123396
66negative regulation of translation, ncRNA-mediated (GO:0040033)3.28123396
67regulation of translation, ncRNA-mediated (GO:0045974)3.28123396
68response to auditory stimulus (GO:0010996)3.26257487
69regulation of establishment of cell polarity (GO:2000114)3.23236804
70negative regulation of systemic arterial blood pressure (GO:0003085)3.21308260
71neurotransmitter transport (GO:0006836)3.21136401
72endosome to melanosome transport (GO:0035646)3.18108966
73endosome to pigment granule transport (GO:0043485)3.18108966
74establishment of protein localization to Golgi (GO:0072600)3.16888124
75snRNA transcription (GO:0009301)3.16185016
76neuron-neuron synaptic transmission (GO:0007270)3.15477856
77tryptophan metabolic process (GO:0006568)3.13330192
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12958571
79cerebellar Purkinje cell layer development (GO:0021680)3.09833696
80glycine transport (GO:0015816)3.09107756
81neuromuscular process controlling balance (GO:0050885)3.08548373
82cardiovascular system development (GO:0072358)3.04986669
83negative regulation of microtubule polymerization (GO:0031115)3.03999104
84negative regulation of protein localization to cell surface (GO:2000009)3.02989600
85cilium movement (GO:0003341)3.02386133
86cellular ketone body metabolic process (GO:0046950)3.00303967
87long-term memory (GO:0007616)3.00270403
88glutamate receptor signaling pathway (GO:0007215)3.00175299
89regulation of synapse maturation (GO:0090128)2.98213546
90mechanosensory behavior (GO:0007638)2.97048672
91regulation of neurotransmitter secretion (GO:0046928)2.96753418
92epithelial cilium movement (GO:0003351)2.94066753
93positive regulation of synaptic transmission, GABAergic (GO:0032230)2.93954317
94postsynaptic membrane organization (GO:0001941)2.93399987
95regulation of neurotransmitter levels (GO:0001505)2.92735814
96neuromuscular process controlling posture (GO:0050884)2.92061163
97regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91441972
98positive regulation of membrane potential (GO:0045838)2.89346157
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88967416
100neuronal action potential (GO:0019228)2.88874426
101protein K48-linked deubiquitination (GO:0071108)2.87616807
102regulation of synaptic plasticity (GO:0048167)2.86338389
103neuronal ion channel clustering (GO:0045161)2.85935033
104regulation of establishment or maintenance of cell polarity (GO:0032878)2.85695913
105reflex (GO:0060004)2.85610149
106sulfation (GO:0051923)2.85435844
107membrane depolarization during action potential (GO:0086010)2.85242535
108regulation of postsynaptic membrane potential (GO:0060078)2.84569751
109detection of light stimulus involved in sensory perception (GO:0050962)2.84352069
110detection of light stimulus involved in visual perception (GO:0050908)2.84352069
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83733467
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83242369
113central nervous system projection neuron axonogenesis (GO:0021952)2.80571040
114axoneme assembly (GO:0035082)2.80125329
115endocardial cushion development (GO:0003197)2.79706254
116phospholipid translocation (GO:0045332)2.77806193
117lipid translocation (GO:0034204)2.77806193
118cilium organization (GO:0044782)2.77396570
119membrane hyperpolarization (GO:0060081)2.77139424
120regulation of neurotransmitter transport (GO:0051588)2.77068898
121cerebellar granule cell differentiation (GO:0021707)2.76553403
122signal peptide processing (GO:0006465)2.76547990
123positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.75454676
124indole-containing compound metabolic process (GO:0042430)2.74849296
125regulation of gene silencing by RNA (GO:0060966)2.74662801
126regulation of posttranscriptional gene silencing (GO:0060147)2.74662801
127regulation of gene silencing by miRNA (GO:0060964)2.74662801
128pyrimidine nucleobase catabolic process (GO:0006208)2.74557816
129neuromuscular synaptic transmission (GO:0007274)2.74360543
130neuromuscular process (GO:0050905)2.74139413
131serotonin metabolic process (GO:0042428)2.73240885
132cilium assembly (GO:0042384)2.72885121
133dendritic spine organization (GO:0097061)2.72739937
134prepulse inhibition (GO:0060134)2.72059566
135cilium morphogenesis (GO:0060271)2.71646281
136positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.71214575
137transmission of nerve impulse (GO:0019226)2.70802471
138regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70390373
139striatum development (GO:0021756)2.70207595
140monoubiquitinated protein deubiquitination (GO:0035520)2.70203092
141ketone body metabolic process (GO:1902224)2.68868927
142regulation of action potential (GO:0098900)2.68854073
143cerebellum development (GO:0021549)2.67780334
144regulation of synaptic transmission, glutamatergic (GO:0051966)2.66672710
145primary amino compound metabolic process (GO:1901160)2.66422865
146innervation (GO:0060384)2.65779867
147vesicle transport along microtubule (GO:0047496)2.64544536
148negative regulation of synaptic transmission, GABAergic (GO:0032229)2.64194824
149synapse organization (GO:0050808)2.63941106
150positive regulation of potassium ion transmembrane transport (GO:1901381)2.63798406
151membrane depolarization (GO:0051899)2.61753175
152regulation of dendritic spine morphogenesis (GO:0061001)2.61515521
153nonmotile primary cilium assembly (GO:0035058)2.61498681
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61380423
155regulation of vesicle fusion (GO:0031338)2.61292805
156startle response (GO:0001964)2.60895877
157cell differentiation in hindbrain (GO:0021533)2.60452019
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.59898268
159protein K11-linked deubiquitination (GO:0035871)2.59540867
160potassium ion import (GO:0010107)2.58448751
161regulation of sarcomere organization (GO:0060297)2.57971756
162spinal cord motor neuron differentiation (GO:0021522)2.56989981
163potassium ion homeostasis (GO:0055075)2.56672237
164behavioral response to ethanol (GO:0048149)2.56642811
165organelle transport along microtubule (GO:0072384)2.56336353
166protein targeting to lysosome (GO:0006622)2.52277644
167establishment of protein localization to vacuole (GO:0072666)2.52277644
168protein targeting to vacuole (GO:0006623)2.52277644
169retinal cone cell development (GO:0046549)2.52250836
170kidney morphogenesis (GO:0060993)2.50334575
171cornea development in camera-type eye (GO:0061303)2.50040768
172motile cilium assembly (GO:0044458)2.47496393
173thyroid hormone metabolic process (GO:0042403)2.47396056
174limb development (GO:0060173)2.46990501
175appendage development (GO:0048736)2.46990501
176ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.46657767
177photoreceptor cell maintenance (GO:0045494)2.45712469
178atrial cardiac muscle cell action potential (GO:0086014)2.44640385
179flavonoid metabolic process (GO:0009812)2.44130683
180pericardium development (GO:0060039)2.42645741
181cAMP catabolic process (GO:0006198)2.42483384
182protein localization to cilium (GO:0061512)2.41515037
183action potential (GO:0001508)2.40170143
184positive regulation of sodium ion transmembrane transport (GO:1902307)2.39871410
185nucleus localization (GO:0051647)2.39794220
186central nervous system neuron axonogenesis (GO:0021955)2.36830731
187benzene-containing compound metabolic process (GO:0042537)2.36699446

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.87017552
2GBX2_23144817_ChIP-Seq_PC3_Human2.99929499
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97457207
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95805992
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74316872
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74186417
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74186417
8DROSHA_22980978_ChIP-Seq_HELA_Human2.69537346
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.65842583
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.65113340
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60823672
12* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59305869
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.53200592
14VDR_22108803_ChIP-Seq_LS180_Human2.52709181
15REST_21632747_ChIP-Seq_MESCs_Mouse2.52523836
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51719815
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51199761
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48468323
19* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.41579053
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40710164
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40641265
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40626975
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.38307539
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37763760
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.37512524
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35456406
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31484789
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30588014
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26977421
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.26795783
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.26001858
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.23738223
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18136956
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10932387
35PIAS1_25552417_ChIP-Seq_VCAP_Human2.05470662
36* TAF15_26573619_Chip-Seq_HEK293_Human2.05291093
37FUS_26573619_Chip-Seq_HEK293_Human1.93801813
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.93581865
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.89415462
40EWS_26573619_Chip-Seq_HEK293_Human1.86399286
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.77667856
42ER_23166858_ChIP-Seq_MCF-7_Human1.77300247
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72187683
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.70751146
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70347262
46AR_21572438_ChIP-Seq_LNCaP_Human1.67293196
47TP53_16413492_ChIP-PET_HCT116_Human1.67196834
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.60255713
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.55800349
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55715683
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54055482
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52458757
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52458757
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52053959
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.51283336
56BCAT_22108803_ChIP-Seq_LS180_Human1.49809832
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49675789
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48560842
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47367648
60KDM2B_26808549_Chip-Seq_K562_Human1.44014733
61ZNF274_21170338_ChIP-Seq_K562_Hela1.43231369
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42173945
63CBP_20019798_ChIP-Seq_JUKART_Human1.42173945
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.41474255
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.41166666
66* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36658572
67AR_19668381_ChIP-Seq_PC3_Human1.34872609
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34134406
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33816471
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32958686
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.31578334
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29865141
73RUNX2_22187159_ChIP-Seq_PCA_Human1.29658296
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29411962
75SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28099837
76TCF4_22108803_ChIP-Seq_LS180_Human1.28048195
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27967497
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.27914859
79TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27554258
80SMAD4_21799915_ChIP-Seq_A2780_Human1.26165161
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25901803
82CBX2_27304074_Chip-Seq_ESCs_Mouse1.24645056
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23647071
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22415723
85EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21812036
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21496422
87OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21142828
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21004792
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18211911
90* PRDM14_20953172_ChIP-Seq_ESCs_Human1.18061748
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17802848
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.17774768
93EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17713178
94PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17362804
95SMAD4_21741376_ChIP-Seq_EPCs_Human1.16881844
96BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16854229
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15924242
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14924427
99* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14455194
100KDM2B_26808549_Chip-Seq_REH_Human1.12877009
101KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12565846
102IRF1_19129219_ChIP-ChIP_H3396_Human1.11834845
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11732813
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.11547737
105CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11494274
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11184356
107EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10722438
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.10295236
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10032235
110SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09963027
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07207413
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.06388657
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05783212
114RXR_22108803_ChIP-Seq_LS180_Human1.05703698
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05000225
116* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04114021
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02950944
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02950944
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.02918370
120* STAT3_23295773_ChIP-Seq_U87_Human1.02795500
121* ARNT_22903824_ChIP-Seq_MCF-7_Human1.02621908
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.02435569
123TP53_20018659_ChIP-ChIP_R1E_Mouse1.01964526
124MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01294727
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01132000
126RNF2_27304074_Chip-Seq_NSC_Mouse0.98999560
127AR_25329375_ChIP-Seq_VCAP_Human0.98632813
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97605840
129TET1_21490601_ChIP-Seq_MESCs_Mouse0.97465009
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97332033
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.96397597
132SMAD4_21741376_ChIP-Seq_HESCs_Human0.95960271
133* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95218011
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94765111
135* AHR_22903824_ChIP-Seq_MCF-7_Human0.94087348
136CTCF_27219007_Chip-Seq_Bcells_Human0.93665665
137P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92684722
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91341361
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.91305089
140ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90014794
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89481626
142TCF4_23295773_ChIP-Seq_U87_Human0.88873948
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87857083
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87462786
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87313831
146IGF1R_20145208_ChIP-Seq_DFB_Human0.87287938
147* ISL1_27105846_Chip-Seq_CPCs_Mouse0.86784460
148P300_19829295_ChIP-Seq_ESCs_Human0.86194764
149SMC4_20622854_ChIP-Seq_HELA_Human0.84009760
150NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83785293
151CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83607324
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.83215360
153TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81756983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.63149964
2MP0003880_abnormal_central_pattern3.92943402
3MP0003635_abnormal_synaptic_transmissio3.54387290
4MP0003122_maternal_imprinting2.99589759
5MP0004270_analgesia2.91870623
6MP0002063_abnormal_learning/memory/cond2.87630216
7MP0005423_abnormal_somatic_nervous2.84904117
8MP0009745_abnormal_behavioral_response2.69487029
9MP0003195_calcinosis2.68471555
10MP0002064_seizures2.65701975
11MP0004043_abnormal_pH_regulation2.54721884
12MP0009046_muscle_twitch2.53400832
13MP0008057_abnormal_DNA_replication2.44898196
14MP0009780_abnormal_chondrocyte_physiolo2.28785694
15MP0002572_abnormal_emotion/affect_behav2.27092933
16MP0001968_abnormal_touch/_nociception2.24612774
17MP0008877_abnormal_DNA_methylation2.21073108
18MP0002272_abnormal_nervous_system2.13876951
19MP0001486_abnormal_startle_reflex2.13263233
20MP0002102_abnormal_ear_morphology2.09897503
21MP0000778_abnormal_nervous_system2.09721576
22MP0002734_abnormal_mechanical_nocicepti2.09569921
23MP0000751_myopathy2.05459294
24MP0002822_catalepsy2.03086106
25MP0000427_abnormal_hair_cycle1.98193211
26MP0005646_abnormal_pituitary_gland1.88365037
27MP0008569_lethality_at_weaning1.85817819
28MP0000569_abnormal_digit_pigmentation1.79202938
29MP0003283_abnormal_digestive_organ1.78648233
30MP0004858_abnormal_nervous_system1.78454912
31MP0004811_abnormal_neuron_physiology1.77036534
32MP0002184_abnormal_innervation1.75489882
33MP0003890_abnormal_embryonic-extraembry1.74504425
34MP0006276_abnormal_autonomic_nervous1.73293969
35MP0002067_abnormal_sensory_capabilities1.70507269
36MP0002736_abnormal_nociception_after1.67187323
37MP0002557_abnormal_social/conspecific_i1.66814478
38MP0001529_abnormal_vocalization1.64864756
39MP0000383_abnormal_hair_follicle1.64576216
40MP0000955_abnormal_spinal_cord1.64137916
41MP0002909_abnormal_adrenal_gland1.63333340
42MP0004233_abnormal_muscle_weight1.62614976
43MP0003787_abnormal_imprinting1.59254467
44MP0001440_abnormal_grooming_behavior1.58795687
45MP0002733_abnormal_thermal_nociception1.55984901
46MP0001501_abnormal_sleep_pattern1.53312710
47MP0005386_behavior/neurological_phenoty1.49361444
48MP0004924_abnormal_behavior1.49361444
49MP0001984_abnormal_olfaction1.49106735
50MP0001970_abnormal_pain_threshold1.49072081
51MP0001485_abnormal_pinna_reflex1.48854367
52MP0005645_abnormal_hypothalamus_physiol1.47894652
53MP0003136_yellow_coat_color1.47305768
54MP0003121_genomic_imprinting1.43506650
55MP0004145_abnormal_muscle_electrophysio1.42394604
56MP0002735_abnormal_chemical_nociception1.41842002
57MP0002882_abnormal_neuron_morphology1.40546553
58MP0002876_abnormal_thyroid_physiology1.40476499
59MP0002653_abnormal_ependyma_morphology1.38736298
60MP0004885_abnormal_endolymph1.35911631
61MP0005253_abnormal_eye_physiology1.35068041
62MP0001502_abnormal_circadian_rhythm1.34741678
63MP0008872_abnormal_physiological_respon1.33683661
64MP0002938_white_spotting1.28242235
65MP0005187_abnormal_penis_morphology1.26988371
66* MP0002066_abnormal_motor_capabilities/c1.26931119
67MP0006292_abnormal_olfactory_placode1.24269323
68MP0002837_dystrophic_cardiac_calcinosis1.23285271
69MP0002152_abnormal_brain_morphology1.21065307
70MP0005174_abnormal_tail_pigmentation1.20687828
71MP0002928_abnormal_bile_duct1.16824329
72MP0001986_abnormal_taste_sensitivity1.16086440
73MP0000013_abnormal_adipose_tissue1.15235704
74MP0003329_amyloid_beta_deposits1.14588723
75MP0002160_abnormal_reproductive_system1.14164668
76MP0003633_abnormal_nervous_system1.08199053
77MP0004142_abnormal_muscle_tone1.07014456
78* MP0008961_abnormal_basal_metabolism1.03968388
79MP0006072_abnormal_retinal_apoptosis1.03343877
80MP0002234_abnormal_pharynx_morphology1.01793308
81MP0005623_abnormal_meninges_morphology1.01269663
82MP0008775_abnormal_heart_ventricle1.00207456
83MP0002089_abnormal_postnatal_growth/wei1.00131501
84MP0000538_abnormal_urinary_bladder0.96836315
85MP0003937_abnormal_limbs/digits/tail_de0.96449046
86MP0005551_abnormal_eye_electrophysiolog0.95754571
87MP0005394_taste/olfaction_phenotype0.93789016
88MP0005499_abnormal_olfactory_system0.93789016
89MP0003137_abnormal_impulse_conducting0.93415573
90MP0003879_abnormal_hair_cell0.93002858
91MP0003123_paternal_imprinting0.92785136
92MP0000230_abnormal_systemic_arterial0.92607477
93MP0002638_abnormal_pupillary_reflex0.92411193
94MP0003045_fibrosis0.91943025
95MP0003119_abnormal_digestive_system0.91054032
96MP0003861_abnormal_nervous_system0.88562243
97MP0003631_nervous_system_phenotype0.88493180
98MP0004085_abnormal_heartbeat0.88331244
99MP0005195_abnormal_posterior_eye0.87637836
100MP0000534_abnormal_ureter_morphology0.87154519
101MP0004147_increased_porphyrin_level0.86950996
102MP0001299_abnormal_eye_distance/0.85332182
103* MP0002069_abnormal_eating/drinking_beha0.85265652
104MP0001177_atelectasis0.84766174
105MP0005389_reproductive_system_phenotype0.84569973
106MP0000631_abnormal_neuroendocrine_gland0.84394260
107MP0010030_abnormal_orbit_morphology0.83364379
108MP0004215_abnormal_myocardial_fiber0.83208954
109MP0003385_abnormal_body_wall0.81340910
110MP0003634_abnormal_glial_cell0.81248863
111MP0004130_abnormal_muscle_cell0.80501666
112MP0008875_abnormal_xenobiotic_pharmacok0.78424946
113MP0010386_abnormal_urinary_bladder0.78103119
114MP0003632_abnormal_nervous_system0.77659645
115MP0002168_other_aberrant_phenotype0.77307968
116MP0002752_abnormal_somatic_nervous0.76561043
117MP0010678_abnormal_skin_adnexa0.75949457
118MP0001943_abnormal_respiration0.75338924
119MP0002229_neurodegeneration0.75204864
120MP0004133_heterotaxia0.75175201
121MP0005171_absent_coat_pigmentation0.74491401
122MP0000537_abnormal_urethra_morphology0.72778658
123MP0001324_abnormal_eye_pigmentation0.72615179
124MP0000747_muscle_weakness0.71185882
125MP0000372_irregular_coat_pigmentation0.70850775
126MP0001963_abnormal_hearing_physiology0.70216158
127MP0001905_abnormal_dopamine_level0.69985875
128MP0000026_abnormal_inner_ear0.68510865
129MP0002108_abnormal_muscle_morphology0.67792164
130MP0004742_abnormal_vestibular_system0.66836695
131* MP0010769_abnormal_survival0.65872014
132MP0000003_abnormal_adipose_tissue0.65130153
133* MP0002082_postnatal_lethality0.64831630
134* MP0010770_preweaning_lethality0.64831630
135MP0000759_abnormal_skeletal_muscle0.63620352
136MP0004036_abnormal_muscle_relaxation0.63245609
137MP0003646_muscle_fatigue0.62853004
138MP0003942_abnormal_urinary_system0.62322311
139MP0000749_muscle_degeneration0.62211886

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.14723597
2Pancreatic cysts (HP:0001737)4.79687372
3Myokymia (HP:0002411)4.75871302
4Pancreatic fibrosis (HP:0100732)4.37130011
5Focal seizures (HP:0007359)4.12188544
6True hermaphroditism (HP:0010459)4.10890154
7Epileptic encephalopathy (HP:0200134)3.78431939
8Abnormality of midbrain morphology (HP:0002418)3.76780081
9Molar tooth sign on MRI (HP:0002419)3.76780081
10Visual hallucinations (HP:0002367)3.68074454
11Nephronophthisis (HP:0000090)3.45309037
12Cystic liver disease (HP:0006706)3.40203645
13Ankle clonus (HP:0011448)3.33569143
14Progressive cerebellar ataxia (HP:0002073)3.30047250
15Medial flaring of the eyebrow (HP:0010747)3.20859125
16Chronic hepatic failure (HP:0100626)3.15350745
17Febrile seizures (HP:0002373)3.12391400
18Atonic seizures (HP:0010819)3.11334440
19Abnormality of the renal medulla (HP:0100957)3.07963562
20Abnormality of the renal cortex (HP:0011035)3.07701619
21Aplasia/Hypoplasia of the tibia (HP:0005772)3.07264029
22Gait imbalance (HP:0002141)3.01011917
23Action tremor (HP:0002345)2.99063790
24Failure to thrive in infancy (HP:0001531)2.94862568
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.93466317
26Absent/shortened dynein arms (HP:0200106)2.93466317
27Supranuclear gaze palsy (HP:0000605)2.89549594
28Clumsiness (HP:0002312)2.89119099
29Depression (HP:0000716)2.88271680
30Abnormal eating behavior (HP:0100738)2.83762279
31Congenital stationary night blindness (HP:0007642)2.78477248
32Congenital primary aphakia (HP:0007707)2.78114166
33Poor eye contact (HP:0000817)2.76143555
34Tubular atrophy (HP:0000092)2.74166944
35Abnormality of the lower motor neuron (HP:0002366)2.70805455
36Urinary urgency (HP:0000012)2.70797322
37Hyperacusis (HP:0010780)2.69221497
38Absence seizures (HP:0002121)2.68051488
39Inability to walk (HP:0002540)2.66990344
40Fair hair (HP:0002286)2.66347978
41Impaired vibration sensation in the lower limbs (HP:0002166)2.62865700
42Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58876435
43Dysdiadochokinesis (HP:0002075)2.58057418
44Generalized tonic-clonic seizures (HP:0002069)2.57911959
45Broad-based gait (HP:0002136)2.57387528
46Patellar aplasia (HP:0006443)2.55789386
47Abnormal social behavior (HP:0012433)2.55277846
48Impaired social interactions (HP:0000735)2.55277846
49Genetic anticipation (HP:0003743)2.54538834
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.53628380
51Insomnia (HP:0100785)2.53178908
52Progressive inability to walk (HP:0002505)2.53141861
53Neoplasm of the heart (HP:0100544)2.52699334
54Nephrogenic diabetes insipidus (HP:0009806)2.50763450
55Furrowed tongue (HP:0000221)2.49588999
56Genital tract atresia (HP:0001827)2.47971237
57Decreased circulating renin level (HP:0003351)2.47160241
58Polyphagia (HP:0002591)2.46946987
59Vaginal atresia (HP:0000148)2.46383098
60Poor coordination (HP:0002370)2.45969755
61Attenuation of retinal blood vessels (HP:0007843)2.43510004
62Urinary bladder sphincter dysfunction (HP:0002839)2.42800711
63Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41353970
64Abnormality of alanine metabolism (HP:0010916)2.41353970
65Hyperalaninemia (HP:0003348)2.41353970
66Large for gestational age (HP:0001520)2.39166981
67* Protruding tongue (HP:0010808)2.38914660
68Postural instability (HP:0002172)2.37884559
69Absent speech (HP:0001344)2.37097157
70Aplasia/Hypoplasia of the patella (HP:0006498)2.36487579
71Narrow nasal bridge (HP:0000446)2.32264765
72Torticollis (HP:0000473)2.31240550
73Pointed chin (HP:0000307)2.31189830
74Birth length less than 3rd percentile (HP:0003561)2.30907724
75Pheochromocytoma (HP:0002666)2.30245872
76Type II lissencephaly (HP:0007260)2.29133056
77Hypoplastic ischia (HP:0003175)2.28739717
78Abnormal respiratory motile cilium morphology (HP:0005938)2.28319599
79Abnormal respiratory epithelium morphology (HP:0012253)2.28319599
80Dialeptic seizures (HP:0011146)2.27785142
81Hypoventilation (HP:0002791)2.27779018
82Scanning speech (HP:0002168)2.27239402
83Polydipsia (HP:0001959)2.26897883
84Abnormal drinking behavior (HP:0030082)2.26897883
85Abolished electroretinogram (ERG) (HP:0000550)2.25755114
86Congenital hepatic fibrosis (HP:0002612)2.23690323
87Abnormal ciliary motility (HP:0012262)2.22389728
88Exercise-induced myalgia (HP:0003738)2.21154457
89Limb dystonia (HP:0002451)2.21153108
90Sclerocornea (HP:0000647)2.20969908
91Fetal akinesia sequence (HP:0001989)2.19379259
92Abnormality of the ischium (HP:0003174)2.18892385
93Widely spaced teeth (HP:0000687)2.18862193
94Truncal ataxia (HP:0002078)2.16014504
95Central scotoma (HP:0000603)2.14777793
96Anencephaly (HP:0002323)2.14224185
97Generalized hypopigmentation of hair (HP:0011358)2.13486391
98Amblyopia (HP:0000646)2.12998967
99Focal dystonia (HP:0004373)2.12488674
100Elfin facies (HP:0004428)2.11363498
101Anxiety (HP:0000739)2.09776357
102Megalencephaly (HP:0001355)2.07626962
103Spastic gait (HP:0002064)2.06551807
104Cerebellar dysplasia (HP:0007033)2.06101077
105Lower limb muscle weakness (HP:0007340)2.06011723
106Gaze-evoked nystagmus (HP:0000640)2.05609244
107Generalized hypotonia (HP:0001290)2.05157393
108Short foot (HP:0001773)2.04585224
109Dysmetria (HP:0001310)2.03664199
110Epileptiform EEG discharges (HP:0011182)2.02526138
111EEG with generalized epileptiform discharges (HP:0011198)2.01259193
112Postaxial foot polydactyly (HP:0001830)2.00936984
113Hyperventilation (HP:0002883)2.00358892
114Dysmetric saccades (HP:0000641)2.00211824
115Renal duplication (HP:0000075)2.00022864
116Male pseudohermaphroditism (HP:0000037)1.99810273
117Increased neuronal autofluorescent lipopigment (HP:0002074)1.99192114
118Hemiplegia (HP:0002301)1.99130808
119Preaxial foot polydactyly (HP:0001841)1.98850374
120Preaxial hand polydactyly (HP:0001177)1.96916584
121Hypsarrhythmia (HP:0002521)1.96235847
122Specific learning disability (HP:0001328)1.95328515
123Hypoplastic labia majora (HP:0000059)1.94740491
124Mutism (HP:0002300)1.94035122
125Drooling (HP:0002307)1.93229353
126Excessive salivation (HP:0003781)1.93229353
127Termporal pattern (HP:0011008)1.93075194
128Insidious onset (HP:0003587)1.93075194
129Sleep apnea (HP:0010535)1.92827535
130Spinal canal stenosis (HP:0003416)1.91927959
131Ventricular fibrillation (HP:0001663)1.91074907
132Papilledema (HP:0001085)1.90615988
133Shoulder girdle muscle weakness (HP:0003547)1.90433026
134Craniofacial dystonia (HP:0012179)1.90040810
135Renal cortical cysts (HP:0000803)1.89791708
136Small hand (HP:0200055)1.89311706
137Overriding aorta (HP:0002623)1.87754963
138Annular pancreas (HP:0001734)1.86658173
139Impaired smooth pursuit (HP:0007772)1.86437751
140Stereotypic behavior (HP:0000733)1.85600913
141Agitation (HP:0000713)1.85530169
142Bulbous nose (HP:0000414)1.84854220
143Increased corneal curvature (HP:0100692)1.84307787
144Keratoconus (HP:0000563)1.84307787
145Abnormality of the labia majora (HP:0012881)1.83428187
146Bony spicule pigmentary retinopathy (HP:0007737)1.83137541
147Hemiparesis (HP:0001269)1.81482904
148Abnormal respiratory motile cilium physiology (HP:0012261)1.81396927
149Hypoplasia of the brainstem (HP:0002365)1.80714706
150Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80714706
151Open mouth (HP:0000194)1.80334399
152Blue irides (HP:0000635)1.80314099
153Bradykinesia (HP:0002067)1.80224215
154Congenital sensorineural hearing impairment (HP:0008527)1.79906770
155Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78447366
156Abnormality of pain sensation (HP:0010832)1.77403926
157Impaired pain sensation (HP:0007328)1.77403926
158Chorioretinal atrophy (HP:0000533)1.76985044
159Highly arched eyebrow (HP:0002553)1.76654795
160Tented upper lip vermilion (HP:0010804)1.76261216
161Concave nail (HP:0001598)1.74189597
162Abnormality of the corticospinal tract (HP:0002492)1.73791827
163Macroorchidism (HP:0000053)1.73685105
164Abnormality of ocular smooth pursuit (HP:0000617)1.73294918
165Increased variability in muscle fiber diameter (HP:0003557)1.71923200
166Renovascular hypertension (HP:0100817)1.71854396
167Thyroid-stimulating hormone excess (HP:0002925)1.71611130
168Neoplasm of the peripheral nervous system (HP:0100007)1.71550164
169Neuroendocrine neoplasm (HP:0100634)1.71146462
170Pachygyria (HP:0001302)1.70345161
171Astigmatism (HP:0000483)1.69202887
172Abnormality of the labia minora (HP:0012880)1.67074993
173Postaxial hand polydactyly (HP:0001162)1.66716707
174Intention tremor (HP:0002080)1.64509624
175Hepatoblastoma (HP:0002884)1.63789272
176Flat cornea (HP:0007720)1.62807283
177Lower limb amyotrophy (HP:0007210)1.60970283
178Clonus (HP:0002169)1.60542109
179Turricephaly (HP:0000262)1.59770598
180Aplasia of the phalanges of the hand (HP:0009802)1.59635225

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.74961077
2ACVR1B3.62469074
3MAP3K93.51771718
4NTRK33.42506288
5BMPR1B3.40849385
6MARK13.18015426
7MAP3K43.07210937
8MINK12.57896370
9AKT32.47293246
10PRKD32.42876379
11PAK62.37958853
12EPHA42.30640966
13NTRK22.21478345
14KSR12.17542939
15DAPK22.12680500
16ADRBK22.09930310
17MAP2K71.99400070
18INSRR1.91827214
19CDK191.90809706
20UHMK11.89193213
21CAMKK11.88378134
22SIK31.87312692
23MAP3K121.85995542
24MAP2K41.83452798
25MKNK21.74579241
26NEK11.70291074
27GRK11.68892867
28TYRO31.65841747
29PHKG21.63667981
30PHKG11.63667981
31WNK31.60266756
32WNK41.56812595
33SIK21.50175457
34ICK1.48999881
35PRPF4B1.48601688
36ADRBK11.42371690
37CDK51.42310264
38MAPK131.41945166
39KSR21.39149400
40ZAK1.33419907
41PNCK1.30675938
42TRIB31.30082119
43MAP4K21.29359105
44TGFBR11.27533094
45STK381.26854412
46NUAK11.25031233
47DAPK11.23723652
48SGK4941.23177691
49SGK2231.23177691
50NTRK11.22855846
51CCNB11.17636464
52PIK3CA1.16397730
53TAOK31.15922265
54STK391.11577033
55PINK11.11375168
56CDK181.10648630
57LMTK21.07467774
58CAMK1D1.06747616
59MAPK151.04453748
60CASK1.04254727
61SGK31.03385074
62CDK151.02972262
63FGFR21.02763324
64TRPM71.02391777
65STK38L1.00648655
66PDGFRA0.99469426
67SGK20.99113977
68PLK20.98231443
69PAK30.97175632
70RIPK10.96629843
71PRKCG0.96380099
72PRKCH0.95744704
73CDK140.95531356
74DDR20.95497027
75CDK11A0.88497399
76LATS20.85492056
77TLK10.84391596
78ERBB30.82592141
79DMPK0.81244020
80MARK20.81014377
81RET0.76971666
82CAMK1G0.75234341
83TNIK0.71885868
84CAMK10.70349302
85MELK0.69290147
86ALK0.69209906
87GRK50.69174908
88MAP3K70.68042286
89PRKAA20.67757214
90MAPKAPK30.67087637
91EPHB20.65812305
92FGFR10.65072654
93PDK30.64398945
94PDK40.64398945
95STK110.64032053
96BCR0.63220697
97BRSK20.62928743
98DYRK1A0.62492074
99PKN10.62458275
100OBSCN0.62210053
101OXSR10.61930042
102PKN20.61541752
103CAMK40.61476960
104CHUK0.59602174
105SIK10.58617966
106SGK10.57156921
107PTK2B0.56827335
108CDC42BPA0.56614613
109PRKAA10.55787159
110FER0.55078216
111MKNK10.55060348
112NLK0.54867945
113LATS10.53390245
114CAMK2A0.53323813
115ROCK20.52773912
116MAPKAPK50.52609500
117PRKCZ0.51971335
118CSNK1A1L0.51516969
119WNK10.51438451
120TAOK10.51323859
121STK30.51238451
122RPS6KA30.50838976
123CAMKK20.50825667
124ERBB20.50345214
125SCYL20.49974428
126TAOK20.49024096
127BRD40.48755558
128RPS6KA20.46792330
129MAPK100.45411227
130TEC0.44860684
131ROCK10.44579787
132CSNK1G20.43328692
133FES0.42741253
134NEK20.41536247
135PIK3CG0.40517085
136MAP2K10.38796104
137FYN0.38593727
138CSNK1D0.38470592
139CAMK2B0.37928759
140TNK20.37923413
141MAP2K60.37596548
142BMX0.36890868
143PDK10.36190978
144PRKACA0.36035311
145RPS6KA60.35636695
146PRKCE0.35104009
147MAPK80.34168357
148MUSK0.33693013
149CHEK20.30422124
150TIE10.30376941
151FLT30.30198826
152CDK30.29683900
153PRKG10.29599267

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.21323161
2Nicotine addiction_Homo sapiens_hsa050333.03545851
3GABAergic synapse_Homo sapiens_hsa047272.47268567
4Circadian entrainment_Homo sapiens_hsa047132.46500973
5Olfactory transduction_Homo sapiens_hsa047402.45396724
6Morphine addiction_Homo sapiens_hsa050322.20981372
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18201712
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.13533557
9Long-term potentiation_Homo sapiens_hsa047202.08815997
10Glutamatergic synapse_Homo sapiens_hsa047242.04641991
11Insulin secretion_Homo sapiens_hsa049112.01098252
12Amphetamine addiction_Homo sapiens_hsa050312.01087871
13Dopaminergic synapse_Homo sapiens_hsa047281.99389679
14ABC transporters_Homo sapiens_hsa020101.93980213
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.91378630
16Linoleic acid metabolism_Homo sapiens_hsa005911.91162560
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88450065
18Tryptophan metabolism_Homo sapiens_hsa003801.80650601
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.80642048
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72495825
21Cholinergic synapse_Homo sapiens_hsa047251.70945076
22Salivary secretion_Homo sapiens_hsa049701.67494873
23Gastric acid secretion_Homo sapiens_hsa049711.63667800
24Cocaine addiction_Homo sapiens_hsa050301.62171629
25Selenocompound metabolism_Homo sapiens_hsa004501.55373065
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55106324
27Oxytocin signaling pathway_Homo sapiens_hsa049211.49875900
28Gap junction_Homo sapiens_hsa045401.47526577
29Renin secretion_Homo sapiens_hsa049241.44193618
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43886629
31Histidine metabolism_Homo sapiens_hsa003401.39295860
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39153684
33Long-term depression_Homo sapiens_hsa047301.36949206
34Axon guidance_Homo sapiens_hsa043601.35968543
35Ether lipid metabolism_Homo sapiens_hsa005651.34635199
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.33401670
37Taste transduction_Homo sapiens_hsa047421.32734660
38Calcium signaling pathway_Homo sapiens_hsa040201.32373106
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31282174
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.28853550
41GnRH signaling pathway_Homo sapiens_hsa049121.27814010
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26579353
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25766482
44Nitrogen metabolism_Homo sapiens_hsa009101.23451668
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23420402
46Lysine degradation_Homo sapiens_hsa003101.21409617
47Melanogenesis_Homo sapiens_hsa049161.20462663
48Serotonergic synapse_Homo sapiens_hsa047261.17860494
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16673134
50cAMP signaling pathway_Homo sapiens_hsa040241.16135657
51Dilated cardiomyopathy_Homo sapiens_hsa054141.16048646
52Caffeine metabolism_Homo sapiens_hsa002321.15786876
53Ovarian steroidogenesis_Homo sapiens_hsa049131.14813333
54Estrogen signaling pathway_Homo sapiens_hsa049151.12888316
55Glioma_Homo sapiens_hsa052141.12845602
56ErbB signaling pathway_Homo sapiens_hsa040121.10489410
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.10396864
58Type II diabetes mellitus_Homo sapiens_hsa049301.09038331
59Collecting duct acid secretion_Homo sapiens_hsa049661.06780937
60Glycerolipid metabolism_Homo sapiens_hsa005611.06634540
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05967036
62cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04887573
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02561025
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01079085
65Fanconi anemia pathway_Homo sapiens_hsa034600.99434742
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97675105
67beta-Alanine metabolism_Homo sapiens_hsa004100.97096816
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96551057
69Vibrio cholerae infection_Homo sapiens_hsa051100.94070160
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94008152
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93971061
72Homologous recombination_Homo sapiens_hsa034400.93269263
73Phototransduction_Homo sapiens_hsa047440.92208227
74Oocyte meiosis_Homo sapiens_hsa041140.91213392
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90813431
76Glucagon signaling pathway_Homo sapiens_hsa049220.88890137
77Cardiac muscle contraction_Homo sapiens_hsa042600.88746532
78Hedgehog signaling pathway_Homo sapiens_hsa043400.87239625
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.85661083
80Chemical carcinogenesis_Homo sapiens_hsa052040.82962370
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.82777483
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81625309
83Endometrial cancer_Homo sapiens_hsa052130.81198264
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80988202
85Propanoate metabolism_Homo sapiens_hsa006400.80951977
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79912356
87Wnt signaling pathway_Homo sapiens_hsa043100.79731801
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79548116
89Basal cell carcinoma_Homo sapiens_hsa052170.76743959
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.76199527
91mTOR signaling pathway_Homo sapiens_hsa041500.75730462
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.74977331
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74563673
94Peroxisome_Homo sapiens_hsa041460.73460665
95MAPK signaling pathway_Homo sapiens_hsa040100.71559516
96Insulin signaling pathway_Homo sapiens_hsa049100.71527158
97Dorso-ventral axis formation_Homo sapiens_hsa043200.70863212
98Thyroid hormone synthesis_Homo sapiens_hsa049180.70640884
99Hippo signaling pathway_Homo sapiens_hsa043900.70587578
100Retinol metabolism_Homo sapiens_hsa008300.70393951
101Circadian rhythm_Homo sapiens_hsa047100.69095696
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67981105
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64789700
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63927840
105Choline metabolism in cancer_Homo sapiens_hsa052310.63516973
106Colorectal cancer_Homo sapiens_hsa052100.63272336
107Endocytosis_Homo sapiens_hsa041440.62472043
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62084430
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61645465
110Basal transcription factors_Homo sapiens_hsa030220.61584236
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60393712
112Rap1 signaling pathway_Homo sapiens_hsa040150.59838929
113Inositol phosphate metabolism_Homo sapiens_hsa005620.58860755
114Renal cell carcinoma_Homo sapiens_hsa052110.58399070
115Mineral absorption_Homo sapiens_hsa049780.57276590
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.57159816
117Non-small cell lung cancer_Homo sapiens_hsa052230.57153192
118Regulation of autophagy_Homo sapiens_hsa041400.56650923
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55320251
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53996354
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53771331
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53669046
123Ras signaling pathway_Homo sapiens_hsa040140.53451072
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51907635
125VEGF signaling pathway_Homo sapiens_hsa043700.51788705
126Pancreatic secretion_Homo sapiens_hsa049720.49534628
127Alcoholism_Homo sapiens_hsa050340.49288250
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49280839
129AMPK signaling pathway_Homo sapiens_hsa041520.48447466
130TGF-beta signaling pathway_Homo sapiens_hsa043500.48255817
131Butanoate metabolism_Homo sapiens_hsa006500.45303871
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44638690
133Arachidonic acid metabolism_Homo sapiens_hsa005900.42092100
134Sphingolipid metabolism_Homo sapiens_hsa006000.41397349
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41212159
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.40551627
137Proteoglycans in cancer_Homo sapiens_hsa052050.40299842
138Bile secretion_Homo sapiens_hsa049760.39126992
139Fatty acid biosynthesis_Homo sapiens_hsa000610.39081853
140Melanoma_Homo sapiens_hsa052180.38730855
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36365648
142One carbon pool by folate_Homo sapiens_hsa006700.34882257
143RNA degradation_Homo sapiens_hsa030180.32790463

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