FTMT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.99534425
2plasma membrane fusion (GO:0045026)9.98132124
3spermatid development (GO:0007286)9.93091889
4motile cilium assembly (GO:0044458)9.62024518
5reproduction (GO:0000003)9.33830293
6regulation of cilium movement (GO:0003352)9.00914334
7cilium movement (GO:0003341)8.34174262
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.76517685
9piRNA metabolic process (GO:0034587)7.50950627
10single fertilization (GO:0007338)7.42911966
11sperm capacitation (GO:0048240)7.41916582
12negative regulation of inclusion body assembly (GO:0090084)7.29301796
13synaptonemal complex organization (GO:0070193)7.26083944
14male meiosis (GO:0007140)7.19053140
15synaptonemal complex assembly (GO:0007130)7.03084652
16spermatogenesis (GO:0007283)6.71380828
17male gamete generation (GO:0048232)6.68931881
18organic cation transport (GO:0015695)6.49623872
19microtubule depolymerization (GO:0007019)6.45411612
20fertilization (GO:0009566)6.33514420
21gamete generation (GO:0007276)6.14641028
22regulation of inclusion body assembly (GO:0090083)6.04592050
23calcium ion-dependent exocytosis (GO:0017156)5.57100489
24germ cell development (GO:0007281)5.53313659
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.40941365
26regulation of microtubule-based movement (GO:0060632)5.31915489
27ventricular system development (GO:0021591)5.30081476
28male meiosis I (GO:0007141)5.06426923
29spermatid nucleus differentiation (GO:0007289)5.02232498
30chromosome condensation (GO:0030261)4.95378113
31cell recognition (GO:0008037)4.94892587
32glycerol ether metabolic process (GO:0006662)4.89812462
33multicellular organismal reproductive process (GO:0048609)4.84743821
34chromosome organization involved in meiosis (GO:0070192)4.79321593
35microtubule severing (GO:0051013)4.76314857
36DNA methylation involved in gamete generation (GO:0043046)4.73357351
37DNA packaging (GO:0006323)4.71378286
38seminiferous tubule development (GO:0072520)4.65768953
39left/right pattern formation (GO:0060972)4.57178425
40ether metabolic process (GO:0018904)4.52803074
41sexual reproduction (GO:0019953)4.33346384
42meiotic nuclear division (GO:0007126)4.33178232
43single strand break repair (GO:0000012)4.15238056
44meiosis I (GO:0007127)4.04935319
45chaperone-mediated protein complex assembly (GO:0051131)4.03557569
46multicellular organismal development (GO:0007275)3.89691806
47genitalia morphogenesis (GO:0035112)3.69741651
48protein polyglutamylation (GO:0018095)3.63102269
49meiotic cell cycle (GO:0051321)3.59973470
50protein refolding (GO:0042026)3.46002890
51monoubiquitinated protein deubiquitination (GO:0035520)3.41905822
52protein K11-linked deubiquitination (GO:0035871)3.35185367
53protein localization to cilium (GO:0061512)3.33205011
54microtubule polymerization or depolymerization (GO:0031109)3.30795978
55regulation of spindle checkpoint (GO:0090231)3.29285134
56glycolytic process (GO:0006096)3.23177775
57sequestering of actin monomers (GO:0042989)3.18390653
58amino-acid betaine transport (GO:0015838)3.16896979
59carnitine transport (GO:0015879)3.16896979
60nucleus organization (GO:0006997)3.13473204
61mitotic sister chromatid cohesion (GO:0007064)3.06884257
62nucleoside diphosphate phosphorylation (GO:0006165)3.03118283
63carnitine transmembrane transport (GO:1902603)3.01381934
64polyol catabolic process (GO:0046174)3.00598666
65alditol metabolic process (GO:0019400)2.94262913
66interferon-gamma secretion (GO:0072643)2.91342711
67cilium organization (GO:0044782)2.88323157
68RNA localization (GO:0006403)2.87565686
69microtubule-based movement (GO:0007018)2.87529597
70meiotic cell cycle process (GO:1903046)2.84739832
71axoneme assembly (GO:0035082)2.77275310
72intraciliary transport (GO:0042073)2.77092887
73cilium assembly (GO:0042384)2.76222436
74negative regulation of organelle assembly (GO:1902116)2.76117974
75synapsis (GO:0007129)2.75342189
76gene silencing by RNA (GO:0031047)2.72350804
77RNA destabilization (GO:0050779)2.71512225
78positive regulation of macrophage activation (GO:0043032)2.70305554
79GTP biosynthetic process (GO:0006183)2.70032737
80cellular component assembly involved in morphogenesis (GO:0010927)2.68353418
81cilium morphogenesis (GO:0060271)2.67334510
82regulation of cilium assembly (GO:1902017)2.66855737
83polyamine biosynthetic process (GO:0006596)2.66823437
84lactate metabolic process (GO:0006089)2.65053869
85peptidyl-glutamic acid modification (GO:0018200)2.58860021
86chromatin silencing (GO:0006342)2.57040069
87gene silencing (GO:0016458)2.47347542
88glycerol metabolic process (GO:0006071)2.43860131
89sperm motility (GO:0030317)14.2916985
90fusion of sperm to egg plasma membrane (GO:0007342)13.1017372
91acrosome reaction (GO:0007340)12.2734246
92cell wall macromolecule catabolic process (GO:0016998)12.2360278
93cell wall macromolecule metabolic process (GO:0044036)12.2360278
94sperm-egg recognition (GO:0035036)11.4383671
95acrosome assembly (GO:0001675)11.0041887
96multicellular organism reproduction (GO:0032504)10.7682569
97binding of sperm to zona pellucida (GO:0007339)10.4822279
98epithelial cilium movement (GO:0003351)10.2558197
99cell-cell recognition (GO:0009988)10.2399844
100axonemal dynein complex assembly (GO:0070286)10.2207922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.69245077
2EZH2_22144423_ChIP-Seq_EOC_Human4.51415162
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94749667
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.20868560
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.80301580
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.75800141
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69372249
8VDR_22108803_ChIP-Seq_LS180_Human2.50797466
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.27573760
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22465102
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.17347208
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.04917654
13ZNF274_21170338_ChIP-Seq_K562_Hela1.92607805
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.91480466
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78104217
16ELK4_26923725_Chip-Seq_MESODERM_Mouse1.75223521
17FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71866217
18STAT1_17558387_ChIP-Seq_HELA_Human1.71325337
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70458577
20TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66292897
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.64895328
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.61215945
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60819222
24WDR5_24793694_ChIP-Seq_LNCAP_Human1.55421168
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52331233
26GATA3_21867929_ChIP-Seq_CD8_Mouse1.49501623
27RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.47044710
28KDM2B_26808549_Chip-Seq_REH_Human1.43115541
29TAL1_26923725_Chip-Seq_HPCs_Mouse1.42000395
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40633732
31FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39573922
32PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.36663389
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35615322
34P53_21459846_ChIP-Seq_SAOS-2_Human1.33476480
35REST_21632747_ChIP-Seq_MESCs_Mouse1.32842754
36LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.31121482
37* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29494266
38* CBP_20019798_ChIP-Seq_JUKART_Human1.29494266
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29149679
40GATA3_21867929_ChIP-Seq_TH1_Mouse1.25409111
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.24194250
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23563719
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.23078459
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21372921
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20554092
46PCGF2_27294783_Chip-Seq_NPCs_Mouse1.18013125
47FLI1_21867929_ChIP-Seq_TH2_Mouse1.17756546
48GF1_26923725_Chip-Seq_HPCs_Mouse1.17470773
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17331924
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17331924
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16721117
52TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16423102
53ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14056979
54SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13947328
55SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12731888
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10086444
57SPI1_26923725_Chip-Seq_HPCs_Mouse1.09964086
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09719228
59* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08959192
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08805298
61ERG_20517297_ChIP-Seq_VCAP_Human1.08560455
62* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07619241
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07542320
64EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04962522
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04766963
66MYC_27129775_Chip-Seq_CORNEA_Mouse1.04673351
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.04037739
68PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03515047
69CRX_20693478_ChIP-Seq_RETINA_Mouse1.03231764
70TAF15_26573619_Chip-Seq_HEK293_Human1.02298041
71ESET_19884257_ChIP-Seq_ESCs_Mouse1.01430970
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01233596
73GATA1_19941827_ChIP-Seq_MEL86_Mouse0.99688858
74NANOG_18555785_Chip-Seq_ESCs_Mouse0.98932367
75* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98496248
76NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98117671
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97873189
78RARA_24833708_ChIP-Seq_LIVER_Mouse0.97542778
79TET1_21451524_ChIP-Seq_MESCs_Mouse0.97233961
80CTCF_20526341_ChIP-Seq_ESCs_Human0.96451701
81JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95624660
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95316811
83SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94837767
84NFYB_21822215_ChIP-Seq_K562_Human0.92701472
85OCT4_18555785_Chip-Seq_ESCs_Mouse0.92559503
86SOX11_22085726_ChIP-Seq_ESNs_Mouse0.92472084
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92185045
88LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90715496
89P53_22387025_ChIP-Seq_ESCs_Mouse0.90457761
90FLI1_21867929_ChIP-Seq_CD8_Mouse0.89763782
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.89377265
92NANOG_20526341_ChIP-Seq_ESCs_Human0.88981441
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88728352
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88672411
95* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88489286
96SOX2_21211035_ChIP-Seq_LN229_Human0.88285258
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87292864
98TBL1_22424771_ChIP-Seq_293T_Human0.86419647
99SOX9_26525672_Chip-Seq_HEART_Mouse0.86118874
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.86063617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.11649164
2MP0001929_abnormal_gametogenesis5.54740810
3MP0008877_abnormal_DNA_methylation4.07871618
4MP0002210_abnormal_sex_determination3.41814910
5MP0002161_abnormal_fertility/fecundity3.34559831
6MP0001145_abnormal_male_reproductive2.89315740
7MP0005670_abnormal_white_adipose2.88143960
8MP0000653_abnormal_sex_gland2.49648066
9MP0002653_abnormal_ependyma_morphology2.39076842
10MP0005410_abnormal_fertilization16.5362401
11MP0002160_abnormal_reproductive_system1.61392018
12MP0005623_abnormal_meninges_morphology1.51513046
13MP0003646_muscle_fatigue1.48289958
14MP0004233_abnormal_muscle_weight1.34081739
15MP0002282_abnormal_trachea_morphology1.32414587
16MP0001765_abnormal_ion_homeostasis1.15277943
17MP0001984_abnormal_olfaction0.96598741
18MP0005647_abnormal_sex_gland0.88773690
19MP0008995_early_reproductive_senescence0.85296065
20MP0008058_abnormal_DNA_repair0.84779249
21MP0005389_reproductive_system_phenotype0.78898807
22MP0003115_abnormal_respiratory_system0.77609341
23MP0009046_muscle_twitch0.76169278
24MP0003878_abnormal_ear_physiology0.73156900
25MP0005377_hearing/vestibular/ear_phenot0.73156900
26MP0002234_abnormal_pharynx_morphology0.72611230
27MP0003011_delayed_dark_adaptation0.68026795
28MP0005636_abnormal_mineral_homeostasis0.63208535
29MP0005666_abnormal_adipose_tissue0.60107458
30MP0003329_amyloid_beta_deposits0.56726952
31MP0000569_abnormal_digit_pigmentation0.56013549
32MP0000358_abnormal_cell_content/0.55310775
33MP0010094_abnormal_chromosome_stability0.51752166
34MP0001324_abnormal_eye_pigmentation0.51720056
35MP0001764_abnormal_homeostasis0.48842644
36MP0001293_anophthalmia0.48288826
37MP0004036_abnormal_muscle_relaxation0.47476781
38MP0009278_abnormal_bone_marrow0.47311645
39MP0003699_abnormal_female_reproductive0.45717137
40MP0005397_hematopoietic_system_phenotyp0.45124972
41MP0001545_abnormal_hematopoietic_system0.45124972
42MP0002269_muscular_atrophy0.45117424
43MP0003950_abnormal_plasma_membrane0.42069376
44MP0002928_abnormal_bile_duct0.40525000
45MP0002736_abnormal_nociception_after0.39481989
46MP0000534_abnormal_ureter_morphology0.39465420
47MP0005253_abnormal_eye_physiology0.38641952
48MP0009115_abnormal_fat_cell0.37970133
49MP0005551_abnormal_eye_electrophysiolog0.37214967
50MP0006036_abnormal_mitochondrial_physio0.36225795
51MP0003111_abnormal_nucleus_morphology0.35428680
52MP0002971_abnormal_brown_adipose0.33241973
53MP0005391_vision/eye_phenotype0.31507897
54MP0003942_abnormal_urinary_system0.30796303
55MP0000604_amyloidosis0.28572476
56MP0004811_abnormal_neuron_physiology0.28489229
57MP0003879_abnormal_hair_cell0.28467038
58MP0004133_heterotaxia0.27472918
59MP0003633_abnormal_nervous_system0.26941131
60MP0001119_abnormal_female_reproductive0.26728608
61MP0003786_premature_aging0.26529048
62MP0001730_embryonic_growth_arrest0.25500365
63MP0003861_abnormal_nervous_system0.24497505
64MP0008961_abnormal_basal_metabolism0.23708897
65MP0002295_abnormal_pulmonary_circulatio0.23347118
66MP0006035_abnormal_mitochondrial_morpho0.23341096
67MP0004019_abnormal_vitamin_homeostasis0.22768587
68MP0004742_abnormal_vestibular_system0.22716245
69MP0002152_abnormal_brain_morphology0.22367902
70MP0003948_abnormal_gas_homeostasis0.22273303
71MP0002102_abnormal_ear_morphology0.21856135
72MP0003631_nervous_system_phenotype0.21334026
73MP0001727_abnormal_embryo_implantation0.20963194
74MP0008007_abnormal_cellular_replicative0.20564203
75MP0001849_ear_inflammation0.20493966
76MP0001968_abnormal_touch/_nociception0.20282732
77MP0002139_abnormal_hepatobiliary_system0.19951634
78MP0005423_abnormal_somatic_nervous0.19703634
79MP0000751_myopathy0.19552933
80MP0005375_adipose_tissue_phenotype0.18969617
81MP0002092_abnormal_eye_morphology0.18888091
82MP0008057_abnormal_DNA_replication0.18650512
83MP0001986_abnormal_taste_sensitivity0.17879760
84MP0004043_abnormal_pH_regulation0.16807816
85* MP0002169_no_abnormal_phenotype0.16798548
86* MP0002873_normal_phenotype0.16582128
87MP0004270_analgesia0.16573418
88MP0004808_abnormal_hematopoietic_stem0.16156944
89MP0000313_abnormal_cell_death0.15948533
90MP0001661_extended_life_span0.15883113
91MP0010307_abnormal_tumor_latency0.15384808
92MP0008569_lethality_at_weaning0.15144642
93MP0002229_neurodegeneration0.14924280
94MP0004145_abnormal_muscle_electrophysio0.14814795
95MP0003959_abnormal_lean_body0.14086579
96MP0002405_respiratory_system_inflammati0.13653645
97MP0003045_fibrosis0.13184932
98MP0002084_abnormal_developmental_patter0.13152017
99MP0002693_abnormal_pancreas_physiology0.12014962
100* MP0000001_mammalian_phenotype0.11984150

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.32837354
2Abnormal respiratory motile cilium morphology (HP:0005938)9.32837354
3Abnormal respiratory motile cilium physiology (HP:0012261)9.22533081
4Rhinitis (HP:0012384)7.49700961
5Chronic bronchitis (HP:0004469)7.24917101
6Abnormal ciliary motility (HP:0012262)7.24217288
7Infertility (HP:0000789)7.02283449
8Nasal polyposis (HP:0100582)6.43609697
9Abnormality of the nasal mucosa (HP:0000433)5.29392155
10Male infertility (HP:0003251)4.85542050
11Bronchitis (HP:0012387)4.63938866
12Bronchiectasis (HP:0002110)4.47002055
13Nephronophthisis (HP:0000090)4.26347427
14Abnormal spermatogenesis (HP:0008669)3.60122873
15Recurrent otitis media (HP:0000403)3.34752613
16Recurrent sinusitis (HP:0011108)3.24844805
17Abnormality of the renal medulla (HP:0100957)3.21839057
18Tubulointerstitial nephritis (HP:0001970)2.93348842
19Recurrent bronchitis (HP:0002837)2.89953377
20Impulsivity (HP:0100710)2.79667917
21Tubular atrophy (HP:0000092)2.61490947
22Gonadotropin excess (HP:0000837)2.57747493
23Molar tooth sign on MRI (HP:0002419)2.52462722
24Abnormality of midbrain morphology (HP:0002418)2.52462722
25Cholecystitis (HP:0001082)2.48599971
26Abnormal gallbladder physiology (HP:0012438)2.48599971
27Tubulointerstitial abnormality (HP:0001969)2.43481319
28Medial flaring of the eyebrow (HP:0010747)2.26240251
29Azoospermia (HP:0000027)2.19969764
30Dyschromatopsia (HP:0007641)2.12004321
31Spastic tetraparesis (HP:0001285)2.09932263
32Dynein arm defect of respiratory motile cilia (HP:0012255)13.5591459
33Absent/shortened dynein arms (HP:0200106)13.5591459
34Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9903988
35Choroideremia (HP:0001139)1.93506570
36Tubulointerstitial fibrosis (HP:0005576)1.90928058
37Heterotopia (HP:0002282)1.83998922
38Postaxial foot polydactyly (HP:0001830)1.83323422
39Decreased central vision (HP:0007663)1.83071420
40Stage 5 chronic kidney disease (HP:0003774)1.80930878
41Polydipsia (HP:0001959)1.75588221
42Abnormal drinking behavior (HP:0030082)1.75588221
43Bile duct proliferation (HP:0001408)1.70612196
44Abnormal biliary tract physiology (HP:0012439)1.70612196
45Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70117669
46Bell-shaped thorax (HP:0001591)1.68367715
47Abnormality of the lower motor neuron (HP:0002366)1.68037533
48Hemorrhage of the eye (HP:0011885)1.67020217
49Congenital hepatic fibrosis (HP:0002612)1.66928727
50Abnormality of the renal cortex (HP:0011035)1.65397531
51Short ribs (HP:0000773)1.61686663
52Abnormality of renal excretion (HP:0011036)1.60818347
53Oculomotor apraxia (HP:0000657)1.56532285
54Neurofibrillary tangles (HP:0002185)1.56075835
55Asymmetric septal hypertrophy (HP:0001670)1.54841568
56Abnormality of permanent molar morphology (HP:0011071)1.51333527
57Abnormality of the dental root (HP:0006486)1.51333527
58Taurodontia (HP:0000679)1.51333527
59Fibular hypoplasia (HP:0003038)1.49783992
60Abnormality of dentin (HP:0010299)1.49733539
61Decreased electroretinogram (ERG) amplitude (HP:0000654)1.48229071
62Amyotrophic lateral sclerosis (HP:0007354)1.44012961
63Renal dysplasia (HP:0000110)1.43949930
64Bundle branch block (HP:0011710)1.40855927
65Abnormality of the dental pulp (HP:0006479)1.39961516
66Abnormality of molar (HP:0011077)1.39821459
67Abnormality of molar morphology (HP:0011070)1.39821459
68Postaxial hand polydactyly (HP:0001162)1.39787059
69Deformed sella turcica (HP:0002681)1.38742831
70Congenital malformation of the right heart (HP:0011723)1.38348789
71Double outlet right ventricle (HP:0001719)1.38348789
72Aplasia/Hypoplasia of the lens (HP:0008063)1.37092550
73Hemiparesis (HP:0001269)1.34107428
74Abnormal urine output (HP:0012590)1.33825052
75Absent epiphyses (HP:0010577)1.33784399
76Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.33784399
77Cystic liver disease (HP:0006706)1.32297299
78Absent frontal sinuses (HP:0002688)1.32283716
79Chronic sinusitis (HP:0011109)1.31923075
80Facial cleft (HP:0002006)1.31356012
81Cerebral inclusion bodies (HP:0100314)1.27530367
82Broad distal phalanx of finger (HP:0009836)1.25175140
83J-shaped sella turcica (HP:0002680)1.24661970
84Easy fatigability (HP:0003388)1.23942271
85Impaired proprioception (HP:0010831)1.22918066
86Constricted visual fields (HP:0001133)1.22904954
87Exercise-induced myalgia (HP:0003738)1.22179133
88Loss of speech (HP:0002371)1.21811079
89Short thorax (HP:0010306)1.21024048
90Nephropathy (HP:0000112)1.20666226
91Cerebellar dysplasia (HP:0007033)1.20569794
92Microglossia (HP:0000171)1.20448281
93Sensory axonal neuropathy (HP:0003390)1.20333694
94Hypercholesterolemia (HP:0003124)1.19703083
95Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.19496857
96Truncal obesity (HP:0001956)1.16253474
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.15272956
98Short femoral neck (HP:0100864)1.14873362
99Supernumerary spleens (HP:0009799)1.14801813
100Myoglobinuria (HP:0002913)1.14729566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.29219511
2PDK48.29219511
3TESK16.16751051
4PDK25.37322144
5PRKD35.24057838
6ICK4.45093012
7PTK2B2.20852645
8PNCK2.12571624
9WNK42.09485100
10STK391.99590612
11STK381.72093688
12DYRK1B1.59667845
13NEK21.57313567
14PDK11.12996906
15MAPK150.94679038
16DYRK30.88221659
17TYRO30.86545197
18WNK10.84938930
19IRAK10.72433457
20PASK0.71005032
21PDPK10.65991910
22CCNB10.65011062
23RIPK40.61969798
24STK30.61786823
25CAMK1G0.60138644
26EEF2K0.57474443
27TESK20.56308794
28MAP2K60.56112265
29TTK0.55392047
30PINK10.51437149
31CHEK20.51217561
32LMTK20.45705021
33IRAK20.40431206
34PAK10.40220860
35MUSK0.39262497
36CHEK10.38526512
37NTRK20.37811833
38PRKCG0.30902275
39PAK20.29973876
40STK38L0.29909644
41MTOR0.28302661
42ATM0.26791912
43MARK20.26088472
44MAP3K100.26052523
45WEE10.25498359
46MAPKAPK50.24509958
47ATR0.24163054
48PAK40.23643828
49CAMKK10.23255548
50CDC70.21775540
51NEK60.20181342
52PLK40.19969875
53PRKAA10.18668025
54PRKCZ0.15618330
55RPS6KB10.14502367
56CDK150.11882427
57PRKCQ0.11556621
58PLK10.11520878
59CDK180.09440191
60CDK11A0.08501193
61BRSK20.08023620
62RPS6KA10.06527518
63GSK3B0.06425268
64PRKG20.05621395
65CSNK2A10.05489503
66CDK140.05143729
67CSNK1D0.03960410
68CDK60.03892672
69BRSK10.03687694
70BMPR1B0.03433042
71STK110.02891150
72CDK20.02735383
73BRAF0.02678824
74PRKG10.02498010
75CDK10.02356998
76MARK30.02181425
77STK100.01872852
78CLK10.01599537
79CAMK2A0.01545234
80PRKACG0.01522276
81CSF1R0.01470845
82MAPK80.01268609
83WNK30.01208359
84CDK120.01140279
85PRKCB0.00896662
86PIM10.00721630
87PKN10.00642650
88CSNK2A20.00526610
89PDGFRB-0.0323091
90ZAP70-0.0237662
91MAP3K5-0.0230460
92RPS6KA3-0.0203735
93CDK4-0.0147446
94PRKACB-0.0136865
95EGFR-0.0117387
96PRKCA-0.0107472
97YES1-0.0102897
98EPHB1-0.0088768
99PRKCD-0.0016034
100PAK6-0.0011013

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.57368854
2Fatty acid biosynthesis_Homo sapiens_hsa000614.50409258
3Pyruvate metabolism_Homo sapiens_hsa006203.46713695
4Vitamin B6 metabolism_Homo sapiens_hsa007503.37790076
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.08697381
6Linoleic acid metabolism_Homo sapiens_hsa005912.99255925
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.74774717
8Glucagon signaling pathway_Homo sapiens_hsa049222.59439873
9Propanoate metabolism_Homo sapiens_hsa006402.55048926
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.45938130
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.44760981
12Basal transcription factors_Homo sapiens_hsa030222.15427232
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.09338138
14Selenocompound metabolism_Homo sapiens_hsa004502.03885620
15Glycerolipid metabolism_Homo sapiens_hsa005611.98425290
16Dorso-ventral axis formation_Homo sapiens_hsa043201.89059399
17PPAR signaling pathway_Homo sapiens_hsa033201.84421980
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.81202691
19Glycerophospholipid metabolism_Homo sapiens_hsa005641.72982072
20Oocyte meiosis_Homo sapiens_hsa041141.71411088
21Fructose and mannose metabolism_Homo sapiens_hsa000511.67390584
22Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.67280735
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.52820951
24Amphetamine addiction_Homo sapiens_hsa050311.49911577
25Mineral absorption_Homo sapiens_hsa049781.49747213
26Pentose phosphate pathway_Homo sapiens_hsa000301.45953470
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.43044282
28Ether lipid metabolism_Homo sapiens_hsa005651.41760806
29Fat digestion and absorption_Homo sapiens_hsa049751.41595177
30Fatty acid metabolism_Homo sapiens_hsa012121.37857083
31Fatty acid degradation_Homo sapiens_hsa000711.36424423
32Carbon metabolism_Homo sapiens_hsa012001.33432612
33Cardiac muscle contraction_Homo sapiens_hsa042601.32945198
34Fanconi anemia pathway_Homo sapiens_hsa034601.28372007
35Antigen processing and presentation_Homo sapiens_hsa046121.21552684
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18187741
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.12803919
38Renin secretion_Homo sapiens_hsa049241.08573200
39Huntingtons disease_Homo sapiens_hsa050161.08247171
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08177982
41mRNA surveillance pathway_Homo sapiens_hsa030151.07703216
42Purine metabolism_Homo sapiens_hsa002300.98675361
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96825124
44Hedgehog signaling pathway_Homo sapiens_hsa043400.91611749
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.90735896
46RNA transport_Homo sapiens_hsa030130.90488342
47Glutathione metabolism_Homo sapiens_hsa004800.88962930
48Collecting duct acid secretion_Homo sapiens_hsa049660.85489326
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.80438489
50Insulin secretion_Homo sapiens_hsa049110.79627110
51Biosynthesis of amino acids_Homo sapiens_hsa012300.79545321
52Arachidonic acid metabolism_Homo sapiens_hsa005900.76424934
53Chemical carcinogenesis_Homo sapiens_hsa052040.76171317
54Bile secretion_Homo sapiens_hsa049760.75345898
55Estrogen signaling pathway_Homo sapiens_hsa049150.75267860
56Long-term potentiation_Homo sapiens_hsa047200.73534189
57Thyroid hormone synthesis_Homo sapiens_hsa049180.70229640
58Legionellosis_Homo sapiens_hsa051340.67411140
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66280050
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.65031254
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64575982
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55149602
63ABC transporters_Homo sapiens_hsa020100.54899606
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53914000
65Calcium signaling pathway_Homo sapiens_hsa040200.52442720
66Pancreatic secretion_Homo sapiens_hsa049720.52438156
67Salivary secretion_Homo sapiens_hsa049700.49894319
68Endocytosis_Homo sapiens_hsa041440.49424926
69Protein digestion and absorption_Homo sapiens_hsa049740.49183226
70Systemic lupus erythematosus_Homo sapiens_hsa053220.48303435
71Inositol phosphate metabolism_Homo sapiens_hsa005620.45622012
72Renin-angiotensin system_Homo sapiens_hsa046140.45071950
73AMPK signaling pathway_Homo sapiens_hsa041520.44270639
74Gastric acid secretion_Homo sapiens_hsa049710.43657019
75Synaptic vesicle cycle_Homo sapiens_hsa047210.43396249
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43356811
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43221365
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42793694
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.40863446
80VEGF signaling pathway_Homo sapiens_hsa043700.36967157
81Metabolic pathways_Homo sapiens_hsa011000.35198721
82Taste transduction_Homo sapiens_hsa047420.35011115
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34321845
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34103042
85Sulfur metabolism_Homo sapiens_hsa009200.31444287
86Circadian entrainment_Homo sapiens_hsa047130.31196120
87cAMP signaling pathway_Homo sapiens_hsa040240.30806848
88Pyrimidine metabolism_Homo sapiens_hsa002400.26714359
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26390449
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25724296
91Alcoholism_Homo sapiens_hsa050340.25094388
92Cocaine addiction_Homo sapiens_hsa050300.19312617
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17220789
94B cell receptor signaling pathway_Homo sapiens_hsa046620.11569799
95HIF-1 signaling pathway_Homo sapiens_hsa040660.11386835
96Basal cell carcinoma_Homo sapiens_hsa052170.11383302
97Wnt signaling pathway_Homo sapiens_hsa043100.10943403
98N-Glycan biosynthesis_Homo sapiens_hsa005100.08110780
99Salmonella infection_Homo sapiens_hsa051320.07248202
100Glutamatergic synapse_Homo sapiens_hsa047240.04563664

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