FTLP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.86272200
2fucose catabolic process (GO:0019317)4.95875053
3L-fucose metabolic process (GO:0042354)4.95875053
4L-fucose catabolic process (GO:0042355)4.95875053
5cellular ketone body metabolic process (GO:0046950)3.85145276
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.82051338
7protein polyglutamylation (GO:0018095)3.79097646
8DNA deamination (GO:0045006)3.78743550
9tryptophan catabolic process (GO:0006569)3.76784791
10indole-containing compound catabolic process (GO:0042436)3.76784791
11indolalkylamine catabolic process (GO:0046218)3.76784791
12platelet dense granule organization (GO:0060155)3.58704864
13negative regulation of telomere maintenance (GO:0032205)3.57986411
14kynurenine metabolic process (GO:0070189)3.57421517
15axoneme assembly (GO:0035082)3.45356914
16response to pheromone (GO:0019236)3.43024238
17ketone body metabolic process (GO:1902224)3.40971511
18detection of light stimulus involved in sensory perception (GO:0050962)3.38326093
19detection of light stimulus involved in visual perception (GO:0050908)3.38326093
20nephron epithelium morphogenesis (GO:0072088)3.30852677
21nephron tubule morphogenesis (GO:0072078)3.30852677
22protein complex biogenesis (GO:0070271)3.27451550
23indolalkylamine metabolic process (GO:0006586)3.22790079
24mitochondrial respiratory chain complex assembly (GO:0033108)3.22089626
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.21017422
26NADH dehydrogenase complex assembly (GO:0010257)3.21017422
27mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21017422
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.16172230
29cornea development in camera-type eye (GO:0061303)3.09831943
30tryptophan metabolic process (GO:0006568)3.04396655
31negative regulation of translation, ncRNA-mediated (GO:0040033)3.03028439
32regulation of translation, ncRNA-mediated (GO:0045974)3.03028439
33negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03028439
34regulation of nuclear cell cycle DNA replication (GO:0033262)3.00200312
35regulation of glucokinase activity (GO:0033131)2.99905665
36regulation of hexokinase activity (GO:1903299)2.99905665
37regulation of microtubule-based movement (GO:0060632)2.99725954
38kidney morphogenesis (GO:0060993)2.96757384
39regulation of cilium movement (GO:0003352)2.94635414
40epithelial cilium movement (GO:0003351)2.92648118
41rRNA catabolic process (GO:0016075)2.88524811
42sulfation (GO:0051923)2.88252077
43negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87902680
44water-soluble vitamin biosynthetic process (GO:0042364)2.84272917
45piRNA metabolic process (GO:0034587)2.83913198
46phosphatidylinositol acyl-chain remodeling (GO:0036149)2.78792565
47positive regulation of triglyceride biosynthetic process (GO:0010867)2.76787515
48hindbrain development (GO:0030902)2.75290504
49respiratory chain complex IV assembly (GO:0008535)2.73628987
50amine catabolic process (GO:0009310)2.73353028
51cellular biogenic amine catabolic process (GO:0042402)2.73353028
52cilium morphogenesis (GO:0060271)2.73350073
53synaptic transmission, cholinergic (GO:0007271)2.72906766
54fucosylation (GO:0036065)2.71326786
55glycerophospholipid catabolic process (GO:0046475)2.71132467
56nonmotile primary cilium assembly (GO:0035058)2.71007604
57positive regulation of fatty acid transport (GO:2000193)2.70762364
58cellular response to ATP (GO:0071318)2.70347467
59protein-cofactor linkage (GO:0018065)2.70278251
60maturation of 5.8S rRNA (GO:0000460)2.68631817
61neuronal action potential (GO:0019228)2.68443764
62regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67381305
63regulation of action potential (GO:0098900)2.67002516
64rhodopsin mediated signaling pathway (GO:0016056)2.64603677
65regulation of triglyceride biosynthetic process (GO:0010866)2.64237266
66negative regulation of reactive oxygen species metabolic process (GO:2000378)2.63832055
67preassembly of GPI anchor in ER membrane (GO:0016254)2.63157787
68atrial cardiac muscle cell action potential (GO:0086014)2.62976893
69cAMP catabolic process (GO:0006198)2.61834461
70indole-containing compound metabolic process (GO:0042430)2.60986931
71gamma-aminobutyric acid transport (GO:0015812)2.59859338
72reflex (GO:0060004)2.59546636
73somite development (GO:0061053)2.58340887
74primary amino compound metabolic process (GO:1901160)2.57301442
75protein import into peroxisome matrix (GO:0016558)2.56694455
76neural tube formation (GO:0001841)2.54793619
77mannosylation (GO:0097502)2.53172132
78pyrimidine nucleobase catabolic process (GO:0006208)2.51541154
79cilium or flagellum-dependent cell motility (GO:0001539)2.50806896
80positive regulation of prostaglandin secretion (GO:0032308)2.50700325
81renal tubule morphogenesis (GO:0061333)2.49376887
82retinal cone cell development (GO:0046549)2.47153215
83cytochrome complex assembly (GO:0017004)2.46131965
84cilium organization (GO:0044782)2.44763989
85replication fork processing (GO:0031297)2.44473364
86energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44429622
87ATP synthesis coupled proton transport (GO:0015986)2.44429622
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.42208567
89regulation of telomere maintenance (GO:0032204)2.41831100
90negative regulation of mast cell activation (GO:0033004)2.41474460
91adaptation of signaling pathway (GO:0023058)2.40210438
92protein K6-linked ubiquitination (GO:0085020)2.39706045
93postsynaptic membrane organization (GO:0001941)2.39288735
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.38672434
95multicellular organism reproduction (GO:0032504)2.38255401
96cilium movement (GO:0003341)2.37648169
97ubiquinone biosynthetic process (GO:0006744)2.35336831
98cilium assembly (GO:0042384)2.33255466
99exogenous drug catabolic process (GO:0042738)2.33229073
100endoderm formation (GO:0001706)2.33064760

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.51796917
2EZH2_22144423_ChIP-Seq_EOC_Human3.72557158
3VDR_22108803_ChIP-Seq_LS180_Human3.46903328
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91606059
5GBX2_23144817_ChIP-Seq_PC3_Human2.40044053
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38099669
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.29082994
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18936082
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.15226442
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10934358
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02337614
12CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97478104
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92778997
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91409367
15IGF1R_20145208_ChIP-Seq_DFB_Human1.85624254
16P300_19829295_ChIP-Seq_ESCs_Human1.79039809
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76881469
18EWS_26573619_Chip-Seq_HEK293_Human1.76460374
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75486967
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71997300
21FUS_26573619_Chip-Seq_HEK293_Human1.68682984
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66975001
23IRF1_19129219_ChIP-ChIP_H3396_Human1.66111951
24ER_23166858_ChIP-Seq_MCF-7_Human1.64894466
25MYC_18940864_ChIP-ChIP_HL60_Human1.64760732
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.62858150
27TAF15_26573619_Chip-Seq_HEK293_Human1.60966878
28REST_21632747_ChIP-Seq_MESCs_Mouse1.60487665
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.58487418
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.57556404
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56990223
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56233074
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.54017284
34* TP53_22573176_ChIP-Seq_HFKS_Human1.52456972
35BCAT_22108803_ChIP-Seq_LS180_Human1.50879759
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.49748408
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.46829526
38NANOG_19829295_ChIP-Seq_ESCs_Human1.45341216
39SOX2_19829295_ChIP-Seq_ESCs_Human1.45341216
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41030990
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.41030990
42AR_25329375_ChIP-Seq_VCAP_Human1.40600961
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.39415919
44STAT3_23295773_ChIP-Seq_U87_Human1.39287668
45AR_21572438_ChIP-Seq_LNCaP_Human1.39220216
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37939279
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37939279
48TCF4_23295773_ChIP-Seq_U87_Human1.36158950
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35448347
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35294612
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.34230727
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33556621
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33220610
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30788949
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29239753
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.26785651
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.26528641
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25869503
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25255377
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.24369887
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24256683
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23872165
63CBP_20019798_ChIP-Seq_JUKART_Human1.23872165
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.23388968
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22334315
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21328567
67* HOXB7_26014856_ChIP-Seq_BT474_Human1.21039349
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20937485
69TCF4_22108803_ChIP-Seq_LS180_Human1.20301449
70SMAD4_21799915_ChIP-Seq_A2780_Human1.18482891
71AR_20517297_ChIP-Seq_VCAP_Human1.17127383
72NCOR_22424771_ChIP-Seq_293T_Human1.16989756
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15421523
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15302916
75KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14650205
76MYC_19829295_ChIP-Seq_ESCs_Human1.14403586
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.13134566
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11322688
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.10566298
80TAF2_19829295_ChIP-Seq_ESCs_Human1.10219540
81REST_18959480_ChIP-ChIP_MESCs_Mouse1.09071202
82RNF2_27304074_Chip-Seq_NSC_Mouse1.08982384
83RUNX2_22187159_ChIP-Seq_PCA_Human1.08431820
84NANOG_20526341_ChIP-Seq_ESCs_Human1.07553226
85EZH2_27304074_Chip-Seq_ESCs_Mouse1.05788322
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.04825124
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04608341
88ERA_21632823_ChIP-Seq_H3396_Human1.04285398
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03587969
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.01897789
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.01551747
92FOXH1_21741376_ChIP-Seq_EPCs_Human1.00392750
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.00059265
94P53_22387025_ChIP-Seq_ESCs_Mouse0.99743784
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99651776
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99035113
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98244736
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97946334
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.96980617
100JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96792565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.02927299
2MP0004147_increased_porphyrin_level2.80694260
3MP0004885_abnormal_endolymph2.78049127
4MP0002102_abnormal_ear_morphology2.72407127
5MP0008877_abnormal_DNA_methylation2.65723071
6MP0005551_abnormal_eye_electrophysiolog2.63378609
7MP0008875_abnormal_xenobiotic_pharmacok2.42680309
8MP0006072_abnormal_retinal_apoptosis2.41612263
9MP0006292_abnormal_olfactory_placode2.33710821
10MP0001986_abnormal_taste_sensitivity2.15186903
11MP0004133_heterotaxia2.08424058
12MP0002876_abnormal_thyroid_physiology2.05157415
13MP0008872_abnormal_physiological_respon2.03555265
14MP0000569_abnormal_digit_pigmentation1.98671309
15MP0003011_delayed_dark_adaptation1.95453600
16MP0003880_abnormal_central_pattern1.92413189
17MP0004142_abnormal_muscle_tone1.88171034
18MP0009745_abnormal_behavioral_response1.84937295
19MP0004043_abnormal_pH_regulation1.84568922
20MP0009046_muscle_twitch1.81956087
21MP0002638_abnormal_pupillary_reflex1.79505216
22MP0002837_dystrophic_cardiac_calcinosis1.79001019
23MP0005253_abnormal_eye_physiology1.75639558
24MP0000427_abnormal_hair_cycle1.74631606
25MP0001968_abnormal_touch/_nociception1.72529919
26MP0002163_abnormal_gland_morphology1.67872529
27MP0003136_yellow_coat_color1.66867254
28MP0005645_abnormal_hypothalamus_physiol1.66453435
29MP0001501_abnormal_sleep_pattern1.64455827
30MP0005084_abnormal_gallbladder_morpholo1.62891953
31MP0006276_abnormal_autonomic_nervous1.62742851
32MP0001485_abnormal_pinna_reflex1.61984418
33MP0004742_abnormal_vestibular_system1.59509375
34MP0002272_abnormal_nervous_system1.57876056
35MP0002735_abnormal_chemical_nociception1.57242868
36MP0002653_abnormal_ependyma_morphology1.49393120
37MP0002938_white_spotting1.48110115
38MP0005379_endocrine/exocrine_gland_phen1.41519344
39MP0002557_abnormal_social/conspecific_i1.38097912
40MP0003646_muscle_fatigue1.37166229
41MP0002572_abnormal_emotion/affect_behav1.37007247
42MP0000631_abnormal_neuroendocrine_gland1.36427600
43MP0001984_abnormal_olfaction1.36065110
44MP0002733_abnormal_thermal_nociception1.34354361
45MP0002736_abnormal_nociception_after1.33952892
46MP0002254_reproductive_system_inflammat1.33026601
47MP0001486_abnormal_startle_reflex1.30461163
48MP0002064_seizures1.30117879
49MP0001529_abnormal_vocalization1.28631144
50MP0005646_abnormal_pituitary_gland1.27218664
51MP0003890_abnormal_embryonic-extraembry1.26247464
52MP0001970_abnormal_pain_threshold1.25560086
53MP0004924_abnormal_behavior1.25142176
54MP0005386_behavior/neurological_phenoty1.25142176
55MP0005167_abnormal_blood-brain_barrier1.22453442
56MP0003787_abnormal_imprinting1.22244510
57MP0000372_irregular_coat_pigmentation1.19786158
58MP0001905_abnormal_dopamine_level1.18585974
59MP0005195_abnormal_posterior_eye1.15476996
60MP0005389_reproductive_system_phenotype1.13729907
61MP0002234_abnormal_pharynx_morphology1.11407701
62MP0001919_abnormal_reproductive_system1.10685268
63MP0003718_maternal_effect1.09861014
64MP0003878_abnormal_ear_physiology1.08620770
65MP0005377_hearing/vestibular/ear_phenot1.08620770
66MP0002063_abnormal_learning/memory/cond1.07939211
67MP0002277_abnormal_respiratory_mucosa1.04716302
68MP0000383_abnormal_hair_follicle1.03593570
69MP0008775_abnormal_heart_ventricle1.02740862
70MP0003283_abnormal_digestive_organ1.02156533
71MP0002928_abnormal_bile_duct1.01298513
72MP0002160_abnormal_reproductive_system1.00876172
73MP0003635_abnormal_synaptic_transmissio1.00613258
74MP0003122_maternal_imprinting0.99710494
75MP0008995_early_reproductive_senescence0.99370602
76MP0000778_abnormal_nervous_system0.97943460
77MP0002067_abnormal_sensory_capabilities0.97834169
78MP0004145_abnormal_muscle_electrophysio0.97206902
79MP0002734_abnormal_mechanical_nocicepti0.93493477
80MP0000230_abnormal_systemic_arterial0.91025317
81MP0010386_abnormal_urinary_bladder0.90621489
82MP0000026_abnormal_inner_ear0.90456289
83MP0001324_abnormal_eye_pigmentation0.88630297
84MP0004215_abnormal_myocardial_fiber0.87769249
85MP0001963_abnormal_hearing_physiology0.87072461
86MP0002752_abnormal_somatic_nervous0.84927176
87MP0005423_abnormal_somatic_nervous0.84492717
88MP0000647_abnormal_sebaceous_gland0.83472311
89MP0001873_stomach_inflammation0.82523927
90MP0004019_abnormal_vitamin_homeostasis0.82280664
91MP0000566_synostosis0.80745025
92MP0001440_abnormal_grooming_behavior0.80742143
93MP0003137_abnormal_impulse_conducting0.79907731
94MP0002693_abnormal_pancreas_physiology0.79106502
95MP0005174_abnormal_tail_pigmentation0.78336354
96MP0001502_abnormal_circadian_rhythm0.78194756
97MP0009379_abnormal_foot_pigmentation0.78147745
98MP0005332_abnormal_amino_acid0.76592343
99MP0000049_abnormal_middle_ear0.74846245
100MP0002229_neurodegeneration0.73824264

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.49956926
2Molar tooth sign on MRI (HP:0002419)4.49956926
3Pancreatic cysts (HP:0001737)4.21712555
4Congenital stationary night blindness (HP:0007642)3.94547199
5Pancreatic fibrosis (HP:0100732)3.80768459
6Abnormality of the renal cortex (HP:0011035)3.74697011
7Nephronophthisis (HP:0000090)3.69227447
8True hermaphroditism (HP:0010459)3.53585460
9Type II lissencephaly (HP:0007260)3.48469127
10Abnormality of the renal medulla (HP:0100957)3.34870059
11Attenuation of retinal blood vessels (HP:0007843)3.31922875
12Inability to walk (HP:0002540)3.07188635
13Pendular nystagmus (HP:0012043)2.98713632
14Birth length less than 3rd percentile (HP:0003561)2.95391950
15Hyperventilation (HP:0002883)2.92365320
16Abnormal drinking behavior (HP:0030082)2.92286629
17Polydipsia (HP:0001959)2.92286629
18Renal cortical cysts (HP:0000803)2.89226584
19Concave nail (HP:0001598)2.88179723
20Large for gestational age (HP:0001520)2.70174691
21Tubular atrophy (HP:0000092)2.66088144
22Cerebellar dysplasia (HP:0007033)2.62518622
23Increased corneal curvature (HP:0100692)2.59701548
24Keratoconus (HP:0000563)2.59701548
25Progressive inability to walk (HP:0002505)2.58904283
26Congenital, generalized hypertrichosis (HP:0004540)2.57638312
27Abnormality of alanine metabolism (HP:0010916)2.55405334
28Hyperalaninemia (HP:0003348)2.55405334
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.55405334
30Broad-based gait (HP:0002136)2.51776590
31Lissencephaly (HP:0001339)2.51705511
32Abolished electroretinogram (ERG) (HP:0000550)2.51508950
33Cystic liver disease (HP:0006706)2.49800463
34Polyuria (HP:0000103)2.49727632
35Patellar aplasia (HP:0006443)2.48135104
36Abnormality of the pons (HP:0007361)2.45705030
37Abnormal rod and cone electroretinograms (HP:0008323)2.43129908
38Decreased circulating renin level (HP:0003351)2.42021285
39Chronic hepatic failure (HP:0100626)2.41306102
40Aplasia/Hypoplasia of the patella (HP:0006498)2.34367673
41Hypoplasia of the pons (HP:0012110)2.28581584
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.28255247
43Absent/shortened dynein arms (HP:0200106)2.28255247
44Medial flaring of the eyebrow (HP:0010747)2.23652115
45Optic disc pallor (HP:0000543)2.23459878
46Fair hair (HP:0002286)2.19091823
47Abnormal respiratory motile cilium morphology (HP:0005938)2.18969598
48Abnormal respiratory epithelium morphology (HP:0012253)2.18969598
49Sclerocornea (HP:0000647)2.16254091
50Furrowed tongue (HP:0000221)2.13581026
51Protruding tongue (HP:0010808)2.12915857
52Acute necrotizing encephalopathy (HP:0006965)2.10626223
53Acute encephalopathy (HP:0006846)2.09097903
54Decreased central vision (HP:0007663)2.08346951
55Abnormal biliary tract physiology (HP:0012439)2.06942133
56Bile duct proliferation (HP:0001408)2.06942133
57Clumsiness (HP:0002312)2.04371570
58Mitochondrial inheritance (HP:0001427)2.01558707
59Abnormal urine output (HP:0012590)2.01134627
60Focal motor seizures (HP:0011153)1.99101056
61Abnormal number of erythroid precursors (HP:0012131)1.96607628
62Pachygyria (HP:0001302)1.96451628
63Absent speech (HP:0001344)1.95414657
64Hyperglycinuria (HP:0003108)1.93351472
65Severe muscular hypotonia (HP:0006829)1.91884181
66Chorioretinal atrophy (HP:0000533)1.91756369
67Progressive macrocephaly (HP:0004481)1.88071581
68Aplasia/Hypoplasia of the tongue (HP:0010295)1.87707024
69Hypothermia (HP:0002045)1.87036672
70Duplicated collecting system (HP:0000081)1.86822949
713-Methylglutaconic aciduria (HP:0003535)1.86562159
72Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83439226
73Increased CSF lactate (HP:0002490)1.82952822
74Abnormality of the renal collecting system (HP:0004742)1.82621331
75Anencephaly (HP:0002323)1.81954760
76Abnormal mitochondria in muscle tissue (HP:0008316)1.81373532
77Widely spaced teeth (HP:0000687)1.80911640
78Stomach cancer (HP:0012126)1.80232498
79Methylmalonic acidemia (HP:0002912)1.79954009
80Agitation (HP:0000713)1.79789791
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79277784
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78986918
83Abnormality of the labia minora (HP:0012880)1.77902084
84Congenital hepatic fibrosis (HP:0002612)1.77522590
85Tachypnea (HP:0002789)1.75624119
86Abnormality of renal excretion (HP:0011036)1.75525207
87Nephrogenic diabetes insipidus (HP:0009806)1.75485894
88Generalized hypopigmentation of hair (HP:0011358)1.75284441
89Optic nerve hypoplasia (HP:0000609)1.69663560
90Male pseudohermaphroditism (HP:0000037)1.69457831
91Gait imbalance (HP:0002141)1.68633986
92Hypoplasia of the fovea (HP:0007750)1.68182538
93Aplasia/Hypoplasia of the fovea (HP:0008060)1.68182538
94Breast hypoplasia (HP:0003187)1.65977378
95Abnormality of renin-angiotensin system (HP:0000847)1.64908685
96Absent thumb (HP:0009777)1.64805625
97Abnormality of cells of the erythroid lineage (HP:0012130)1.64502572
98Hypomagnesemia (HP:0002917)1.62853445
99Partial agenesis of the corpus callosum (HP:0001338)1.59454039
100Congenital primary aphakia (HP:0007707)1.59253214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.17340150
2ADRBK23.82956935
3INSRR3.62886616
4ACVR1B3.06947891
5BMPR1B2.96178284
6WNK42.95008983
7CASK2.80752969
8ZAK2.66575978
9TLK12.65172973
10GRK12.57699845
11WNK32.46488620
12NUAK12.40381129
13PINK12.12082648
14DAPK21.96960701
15MAPK131.95034656
16MAP4K21.73318842
17CAMKK21.71788136
18OXSR11.61163115
19MKNK21.51794764
20TAOK31.48277735
21TXK1.46349843
22ADRBK11.41461437
23STK38L1.36719401
24TGFBR11.29145251
25MAP3K41.27470995
26STK391.25083868
27PNCK1.23685158
28TNIK1.18797261
29DYRK21.06600064
30NTRK31.04658942
31PAK31.03969454
32PTK2B0.92977334
33NME10.92008182
34PHKG20.90944088
35PHKG10.90944088
36PRKCE0.90490839
37MARK10.90447823
38CSNK1G20.89917160
39TRIM280.88598168
40TIE10.88247640
41CAMKK10.84671759
42VRK10.84160381
43NTRK20.83968661
44MUSK0.82409986
45FGFR20.80736345
46IKBKB0.80344910
47PRKCG0.79564375
48CAMK1D0.79218871
49NEK20.78925651
50BRSK20.78295298
51MAP2K60.76235499
52PLK20.69885621
53PIK3CA0.69848560
54MKNK10.67253019
55WNK10.66431507
56MAP2K70.66097741
57RPS6KA50.65080158
58PRKCQ0.64955875
59CSNK1G10.64607350
60STK110.63126536
61MAPKAPK30.62884028
62EPHB20.62779368
63CSNK1G30.61164305
64CAMK10.60018381
65CAMK1G0.59745718
66MAPK150.58868336
67PRKCI0.55841882
68BCKDK0.55341198
69MAP2K20.53977307
70CAMK2A0.52309950
71FLT30.51570499
72SIK20.51511447
73NLK0.51499084
74VRK20.50559092
75PLK40.48559223
76PRKACA0.47864115
77CDK30.47286559
78PKN10.42462960
79CHUK0.42086590
80KIT0.41183971
81PASK0.39824347
82WEE10.39782783
83CSNK1A1L0.38612364
84BCR0.38491689
85GRK70.38377889
86PLK30.37818743
87PRKG10.34693922
88CSNK1A10.33201171
89PRKD30.32155151
90PRKCA0.32146326
91RPS6KA60.30629345
92CSNK1D0.30255375
93MAPKAPK50.29642430
94MST40.29418340
95ERBB30.28145299
96STK30.27227648
97PRKCZ0.27180971
98CAMK40.26983874
99PRKAA20.26923643
100LIMK10.26559853

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.89468172
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.79462870
3Linoleic acid metabolism_Homo sapiens_hsa005912.67885710
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67175181
5Nitrogen metabolism_Homo sapiens_hsa009102.63075635
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.53745196
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.53452188
8Butanoate metabolism_Homo sapiens_hsa006502.43873725
9Oxidative phosphorylation_Homo sapiens_hsa001902.33478525
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.17419346
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11857172
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.10835096
13Selenocompound metabolism_Homo sapiens_hsa004502.01876898
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00957481
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.97734849
16Ether lipid metabolism_Homo sapiens_hsa005651.96237661
17Protein export_Homo sapiens_hsa030601.94497340
18Nicotine addiction_Homo sapiens_hsa050331.87291513
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.78209264
20Tryptophan metabolism_Homo sapiens_hsa003801.75319073
21Parkinsons disease_Homo sapiens_hsa050121.73837800
22Caffeine metabolism_Homo sapiens_hsa002321.58416488
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.46004779
24Cardiac muscle contraction_Homo sapiens_hsa042601.43257685
25RNA polymerase_Homo sapiens_hsa030201.35510542
26Homologous recombination_Homo sapiens_hsa034401.34935020
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34203604
28Taste transduction_Homo sapiens_hsa047421.32042279
29Peroxisome_Homo sapiens_hsa041461.27252683
30Fanconi anemia pathway_Homo sapiens_hsa034601.26969847
31Chemical carcinogenesis_Homo sapiens_hsa052041.26167558
32Basal transcription factors_Homo sapiens_hsa030221.24588682
33Propanoate metabolism_Homo sapiens_hsa006401.23867766
34Morphine addiction_Homo sapiens_hsa050321.22179039
35Insulin secretion_Homo sapiens_hsa049111.21341191
36Alzheimers disease_Homo sapiens_hsa050101.16797547
37ABC transporters_Homo sapiens_hsa020101.15885630
38Retinol metabolism_Homo sapiens_hsa008301.15380159
39Huntingtons disease_Homo sapiens_hsa050161.14120584
40Olfactory transduction_Homo sapiens_hsa047401.13954379
41One carbon pool by folate_Homo sapiens_hsa006701.12091005
42RNA degradation_Homo sapiens_hsa030181.11074533
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.03693832
44beta-Alanine metabolism_Homo sapiens_hsa004101.03437357
45Arachidonic acid metabolism_Homo sapiens_hsa005901.03403464
46Ribosome_Homo sapiens_hsa030101.03230045
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02310630
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02020416
49Histidine metabolism_Homo sapiens_hsa003400.96801529
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96197954
51Serotonergic synapse_Homo sapiens_hsa047260.95421286
52Ovarian steroidogenesis_Homo sapiens_hsa049130.94124890
53Regulation of autophagy_Homo sapiens_hsa041400.93324943
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.89811698
55Circadian entrainment_Homo sapiens_hsa047130.88546181
56GABAergic synapse_Homo sapiens_hsa047270.87505737
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86781148
58Glycerolipid metabolism_Homo sapiens_hsa005610.85946870
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85272386
60Fat digestion and absorption_Homo sapiens_hsa049750.82953884
61Intestinal immune network for IgA production_Homo sapiens_hsa046720.79447232
62Sulfur metabolism_Homo sapiens_hsa009200.77521865
63Vitamin digestion and absorption_Homo sapiens_hsa049770.77390339
64Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72618488
65Glutamatergic synapse_Homo sapiens_hsa047240.70881562
66Mineral absorption_Homo sapiens_hsa049780.70565387
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67135973
68Calcium signaling pathway_Homo sapiens_hsa040200.64915527
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64437278
70Cyanoamino acid metabolism_Homo sapiens_hsa004600.61201997
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60099131
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59730868
73Metabolic pathways_Homo sapiens_hsa011000.58948434
74Collecting duct acid secretion_Homo sapiens_hsa049660.58928009
75Proteasome_Homo sapiens_hsa030500.57771354
76Steroid biosynthesis_Homo sapiens_hsa001000.55106789
77Sulfur relay system_Homo sapiens_hsa041220.54351415
78Cocaine addiction_Homo sapiens_hsa050300.53744226
79Primary immunodeficiency_Homo sapiens_hsa053400.52858956
80Fatty acid biosynthesis_Homo sapiens_hsa000610.52112526
81Type I diabetes mellitus_Homo sapiens_hsa049400.51669795
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51094920
83Salivary secretion_Homo sapiens_hsa049700.50745930
84Asthma_Homo sapiens_hsa053100.49747074
85Amphetamine addiction_Homo sapiens_hsa050310.49176455
86Purine metabolism_Homo sapiens_hsa002300.48496449
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44215719
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.44182814
89Dopaminergic synapse_Homo sapiens_hsa047280.39748059
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39259683
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38906242
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38561732
93Circadian rhythm_Homo sapiens_hsa047100.38175730
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37279726
95Fatty acid degradation_Homo sapiens_hsa000710.37049557
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.36235975
97Arginine and proline metabolism_Homo sapiens_hsa003300.35696400
98cAMP signaling pathway_Homo sapiens_hsa040240.35691772
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29028960
100Thyroid hormone synthesis_Homo sapiens_hsa049180.26305676

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