FTH1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.35924843
2cytidine deamination (GO:0009972)7.35924843
3cytidine metabolic process (GO:0046087)7.35924843
4DNA deamination (GO:0045006)6.96419486
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.63602677
6pyrimidine ribonucleoside catabolic process (GO:0046133)6.44495619
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.84970917
8actin nucleation (GO:0045010)4.43978673
9negative regulation of T cell apoptotic process (GO:0070233)4.32264907
10protein neddylation (GO:0045116)4.07435397
11eosinophil chemotaxis (GO:0048245)4.00760056
12positive thymic T cell selection (GO:0045059)3.99301961
13pyrimidine nucleoside catabolic process (GO:0046135)3.92628150
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.85940062
15regulation of activation of Janus kinase activity (GO:0010533)3.85605466
16regulation of chronic inflammatory response (GO:0002676)3.71248091
17negative regulation by host of viral transcription (GO:0043922)3.70917319
18regulation of regulatory T cell differentiation (GO:0045589)3.69296223
19eosinophil migration (GO:0072677)3.61399912
20positive T cell selection (GO:0043368)3.57970394
21positive regulation of interleukin-8 secretion (GO:2000484)3.57339692
22immunoglobulin mediated immune response (GO:0016064)3.56789170
23positive regulation of monocyte chemotaxis (GO:0090026)3.53115963
24sequestering of actin monomers (GO:0042989)3.48136025
25positive regulation of B cell differentiation (GO:0045579)3.43013573
26T cell migration (GO:0072678)3.42903805
27positive regulation of natural killer cell mediated immunity (GO:0002717)3.42843192
28negative regulation of viral genome replication (GO:0045071)3.39879142
29platelet dense granule organization (GO:0060155)3.31310434
30positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.30781732
31positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.29189379
32positive regulation of calcium-mediated signaling (GO:0050850)3.23919699
33positive regulation of defense response to virus by host (GO:0002230)3.22949912
34positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21419719
35T cell costimulation (GO:0031295)3.18879900
36negative regulation of lymphocyte apoptotic process (GO:0070229)3.17213739
37lymphocyte costimulation (GO:0031294)3.15393562
38regulation of natural killer cell mediated immunity (GO:0002715)3.14920794
39regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.14920794
40positive regulation of gamma-delta T cell activation (GO:0046645)3.12043930
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11665893
42positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10746060
43regulation of B cell receptor signaling pathway (GO:0050855)3.05889735
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.04910759
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.03781368
46granulocyte activation (GO:0036230)2.99704322
47regulation of T cell apoptotic process (GO:0070232)2.98286660
48macrophage chemotaxis (GO:0048246)2.95501585
49B cell mediated immunity (GO:0019724)2.94917672
50metallo-sulfur cluster assembly (GO:0031163)2.94180121
51iron-sulfur cluster assembly (GO:0016226)2.94180121
52regulation of interleukin-8 secretion (GO:2000482)2.92573248
53positive regulation of cell killing (GO:0031343)2.91824810
54T cell receptor signaling pathway (GO:0050852)2.90104278
55mast cell activation (GO:0045576)2.89910359
56regulation of T cell tolerance induction (GO:0002664)2.89645150
57regulation of T cell mediated cytotoxicity (GO:0001914)2.89114238
58positive regulation of interleukin-1 beta secretion (GO:0050718)2.89056288
59neutrophil activation (GO:0042119)2.87753006
60regulation of alpha-beta T cell proliferation (GO:0046640)2.87192019
61positive regulation of T cell apoptotic process (GO:0070234)2.85164307
62positive regulation of lymphocyte migration (GO:2000403)2.84919702
63regulation of lymphocyte chemotaxis (GO:1901623)2.83323154
64response to interferon-beta (GO:0035456)2.83152676
65cellular response to interleukin-15 (GO:0071350)2.81908004
66negative T cell selection (GO:0043383)2.81725794
67cytolysis (GO:0019835)2.79899932
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79740584
69adaptation of signaling pathway (GO:0023058)2.75687444
70regulation of cell killing (GO:0031341)2.74215514
71positive regulation of tolerance induction (GO:0002645)2.73655294
72positive regulation of interleukin-1 secretion (GO:0050716)2.70758052
73energy coupled proton transport, down electrochemical gradient (GO:0015985)2.70546096
74ATP synthesis coupled proton transport (GO:0015986)2.70546096
75neutrophil activation involved in immune response (GO:0002283)2.69597134
76regulation of interleukin-1 beta secretion (GO:0050706)2.68365118
77negative regulation of calcium ion transport into cytosol (GO:0010523)2.66905550
78regulation of T cell receptor signaling pathway (GO:0050856)2.64765441
79positive regulation of T cell chemotaxis (GO:0010820)2.63685664
80regulation of T cell chemotaxis (GO:0010819)2.63685664
81mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61967787
82antigen receptor-mediated signaling pathway (GO:0050851)2.60022418
83pyrimidine-containing compound catabolic process (GO:0072529)2.60020841
84negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.58560716
85antigen processing and presentation via MHC class Ib (GO:0002475)2.58069419
86lymphocyte chemotaxis (GO:0048247)2.57577087
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.54193786
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.54193786
89regulation of calcium-mediated signaling (GO:0050848)2.54105296
90negative regulation of leukocyte apoptotic process (GO:2000107)2.53402162
91regulation of lymphocyte apoptotic process (GO:0070228)2.53371901
92regulation of mononuclear cell migration (GO:0071675)2.51417012
93mast cell activation involved in immune response (GO:0002279)2.50533551
94mast cell degranulation (GO:0043303)2.50533551
95negative regulation of mast cell activation (GO:0033004)2.50513090
96electron transport chain (GO:0022900)2.49863645
97respiratory electron transport chain (GO:0022904)2.49628405
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48730131
99regulation of B cell differentiation (GO:0045577)2.47710462
100mannosylation (GO:0097502)2.47557625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.33148702
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.21723041
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.07228942
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38302955
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.05737527
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.94422723
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93675678
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.86716651
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85715755
10EZH2_22144423_ChIP-Seq_EOC_Human2.81210949
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.68043195
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47855016
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44952156
14VDR_22108803_ChIP-Seq_LS180_Human2.22289179
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06903625
16MYB_26560356_Chip-Seq_TH2_Human2.05061435
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.90619412
18RUNX_20019798_ChIP-Seq_JUKART_Human1.85171757
19ZNF274_21170338_ChIP-Seq_K562_Hela1.80016578
20STAT4_19710469_ChIP-ChIP_TH1__Mouse1.72290308
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69691688
22GATA3_26560356_Chip-Seq_TH2_Human1.68892550
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65666851
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65510982
25GATA3_27048872_Chip-Seq_THYMUS_Human1.64525922
26LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62161978
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.60414230
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49640134
29GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.49175390
30TP53_22573176_ChIP-Seq_HFKS_Human1.49128451
31VDR_23849224_ChIP-Seq_CD4+_Human1.48809660
32IGF1R_20145208_ChIP-Seq_DFB_Human1.46881362
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.42835283
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41633020
35PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.39843140
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.39061806
37AR_20517297_ChIP-Seq_VCAP_Human1.38329174
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38229001
39NANOG_20526341_ChIP-Seq_ESCs_Human1.34701181
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.33212248
41TAF2_19829295_ChIP-Seq_ESCs_Human1.31742363
42STAT1_20625510_ChIP-Seq_HELA_Human1.29637277
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.28592829
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28592829
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.27562559
46BCL6_27268052_Chip-Seq_Bcells_Human1.27552488
47RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25669005
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.25082586
49HTT_18923047_ChIP-ChIP_STHdh_Human1.24385022
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.23229151
51NANOG_19829295_ChIP-Seq_ESCs_Human1.22620917
52SOX2_19829295_ChIP-Seq_ESCs_Human1.22620917
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.21952339
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21056392
55AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20769574
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20681236
57MYB_26560356_Chip-Seq_TH1_Human1.20153585
58MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.19376145
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.19074728
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.16006501
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14597211
62SPI1_23547873_ChIP-Seq_NB4_Human1.13747452
63FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12769055
64NCOR_22424771_ChIP-Seq_293T_Human1.12016132
65STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10991080
66STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09788573
67FOXP3_21729870_ChIP-Seq_TREG_Human1.07493114
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06747050
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05978395
70PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03695556
71FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03456989
72MYC_19829295_ChIP-Seq_ESCs_Human1.03202646
73UTX_26944678_Chip-Seq_JUKART_Human1.02401358
74GATA6_21074721_ChIP-Seq_CACO-2_Human1.01445615
75GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.01433953
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00971986
77ER_23166858_ChIP-Seq_MCF-7_Human1.00112151
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99891805
79ERG_20517297_ChIP-Seq_VCAP_Human0.98781440
80ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98414090
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96068424
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94589328
83MYC_18940864_ChIP-ChIP_HL60_Human0.94487384
84GATA3_26560356_Chip-Seq_TH1_Human0.93977229
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93870788
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93442600
87P300_27268052_Chip-Seq_Bcells_Human0.92780854
88RBPJ_21746931_ChIP-Seq_IB4_Human0.90758985
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90201553
90YY1_22570637_ChIP-Seq_MALME-3M_Human0.89898850
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89170010
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88917537
93P300_19829295_ChIP-Seq_ESCs_Human0.88429317
94IRF1_19129219_ChIP-ChIP_H3396_Human0.88333916
95CIITA_25753668_ChIP-Seq_RAJI_Human0.87620504
96ETS1_20019798_ChIP-Seq_JURKAT_Human0.87207077
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.87098663
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85957308
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.85868666
100BCAT_22108803_ChIP-Seq_LS180_Human0.85533360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.23961542
2MP0001835_abnormal_antigen_presentation3.36648654
3MP0009785_altered_susceptibility_to3.28624245
4MP0002148_abnormal_hypersensitivity_rea2.99600059
5MP0005464_abnormal_platelet_physiology2.93952853
6MP0003724_increased_susceptibility_to2.61446783
7MP0005000_abnormal_immune_tolerance2.57905815
8MP0003646_muscle_fatigue2.48447034
9MP0001800_abnormal_humoral_immune2.27091730
10MP0006082_CNS_inflammation2.26819117
11MP0002723_abnormal_immune_serum2.19021217
12MP0005025_abnormal_response_to2.18340383
13MP0002138_abnormal_hepatobiliary_system2.13471753
14MP0002102_abnormal_ear_morphology2.09099603
15MP0009764_decreased_sensitivity_to2.04035058
16MP0002420_abnormal_adaptive_immunity2.03682695
17MP0004147_increased_porphyrin_level1.99000391
18MP0001819_abnormal_immune_cell1.98992349
19MP0003806_abnormal_nucleotide_metabolis1.96441256
20MP0009333_abnormal_splenocyte_physiolog1.95302209
21MP0003763_abnormal_thymus_physiology1.92985432
22MP0002452_abnormal_antigen_presenting1.92191909
23MP0002837_dystrophic_cardiac_calcinosis1.88305972
24MP0005387_immune_system_phenotype1.80469608
25MP0001790_abnormal_immune_system1.80469608
26MP0003866_abnormal_defecation1.79782766
27MP0010155_abnormal_intestine_physiology1.77981341
28MP0005646_abnormal_pituitary_gland1.62492336
29MP0003436_decreased_susceptibility_to1.59868776
30MP0000685_abnormal_immune_system1.59737100
31MP0005075_abnormal_melanosome_morpholog1.56330116
32MP0002419_abnormal_innate_immunity1.56324222
33MP0001845_abnormal_inflammatory_respons1.55138145
34MP0000716_abnormal_immune_system1.54823517
35MP0002398_abnormal_bone_marrow1.52621782
36MP0005410_abnormal_fertilization1.51121320
37MP0000372_irregular_coat_pigmentation1.50245197
38MP0001873_stomach_inflammation1.46089738
39MP0005645_abnormal_hypothalamus_physiol1.41358961
40MP0000689_abnormal_spleen_morphology1.35229530
41MP0002736_abnormal_nociception_after1.32284658
42MP0008872_abnormal_physiological_respon1.31824478
43MP0008004_abnormal_stomach_pH1.31818711
44MP0002405_respiratory_system_inflammati1.30861821
45MP0005083_abnormal_biliary_tract1.29074821
46MP0009763_increased_sensitivity_to1.24740941
47MP0008469_abnormal_protein_level1.23747075
48MP0005084_abnormal_gallbladder_morpholo1.22320338
49MP0002166_altered_tumor_susceptibility1.22082807
50MP0002429_abnormal_blood_cell1.21963927
51MP0002722_abnormal_immune_system1.21089466
52MP0003045_fibrosis1.14778877
53MP0005551_abnormal_eye_electrophysiolog1.14283986
54MP0001919_abnormal_reproductive_system1.13315271
55MP0003011_delayed_dark_adaptation1.08134599
56MP0005085_abnormal_gallbladder_physiolo1.06988852
57MP0000465_gastrointestinal_hemorrhage1.06541281
58MP0005167_abnormal_blood-brain_barrier1.04661267
59MP0009765_abnormal_xenobiotic_induced1.02970802
60MP0005389_reproductive_system_phenotype1.02936568
61MP0008875_abnormal_xenobiotic_pharmacok1.02650737
62MP0006276_abnormal_autonomic_nervous0.99845552
63MP0005377_hearing/vestibular/ear_phenot0.99840385
64MP0003878_abnormal_ear_physiology0.99840385
65MP0002006_tumorigenesis0.99766398
66MP0006072_abnormal_retinal_apoptosis0.98737512
67MP0002095_abnormal_skin_pigmentation0.98145643
68MP0003448_altered_tumor_morphology0.97838075
69MP0001968_abnormal_touch/_nociception0.97382364
70MP0001533_abnormal_skeleton_physiology0.95971904
71MP0003075_altered_response_to0.95378391
72MP0005360_urolithiasis0.92827935
73MP0001905_abnormal_dopamine_level0.92303367
74MP0000343_altered_response_to0.91545289
75MP0005166_decreased_susceptibility_to0.90586853
76MP0000703_abnormal_thymus_morphology0.89962581
77MP0004947_skin_inflammation0.87806580
78MP0005636_abnormal_mineral_homeostasis0.87650736
79MP0006292_abnormal_olfactory_placode0.86327652
80MP0002933_joint_inflammation0.85831498
81MP0002733_abnormal_thermal_nociception0.85709533
82MP0003195_calcinosis0.84985653
83MP0002876_abnormal_thyroid_physiology0.84670508
84MP0000230_abnormal_systemic_arterial0.84438627
85MP0001970_abnormal_pain_threshold0.80580392
86MP0001485_abnormal_pinna_reflex0.80562403
87MP0001764_abnormal_homeostasis0.78496187
88MP0004142_abnormal_muscle_tone0.78062782
89MP0005253_abnormal_eye_physiology0.77441136
90MP0006036_abnormal_mitochondrial_physio0.77071145
91MP0004145_abnormal_muscle_electrophysio0.75950917
92MP0008877_abnormal_DNA_methylation0.75619700
93MP0001765_abnormal_ion_homeostasis0.75257938
94MP0003136_yellow_coat_color0.74671883
95MP0001501_abnormal_sleep_pattern0.73734147
96MP0009643_abnormal_urine_homeostasis0.73382473
97MP0002653_abnormal_ependyma_morphology0.72074781
98MP0000858_altered_metastatic_potential0.71685161
99MP0001542_abnormal_bone_strength0.71662734
100MP0003137_abnormal_impulse_conducting0.71363273

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.47024599
2T lymphocytopenia (HP:0005403)4.08710831
3Elevated erythrocyte sedimentation rate (HP:0003565)4.00895474
4Abnormality of T cell number (HP:0011839)3.89681342
5IgG deficiency (HP:0004315)3.88976531
6Hypoproteinemia (HP:0003075)3.61569043
7Absent rod-and cone-mediated responses on ERG (HP:0007688)3.41051757
8Mitochondrial inheritance (HP:0001427)3.35361350
93-Methylglutaconic aciduria (HP:0003535)3.34316625
10Increased intramyocellular lipid droplets (HP:0012240)3.32472121
11Congenital stationary night blindness (HP:0007642)3.27958857
12Acute necrotizing encephalopathy (HP:0006965)3.23372394
13Decreased central vision (HP:0007663)3.19438642
14Abnormal mitochondria in muscle tissue (HP:0008316)3.19372646
15Abnormality of the prostate (HP:0008775)3.14447234
16Hepatocellular necrosis (HP:0001404)3.14313397
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.13965485
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.13965485
19Decreased electroretinogram (ERG) amplitude (HP:0000654)3.07518111
20Stomatitis (HP:0010280)3.07421172
21Autoimmune hemolytic anemia (HP:0001890)3.04799883
22Severe combined immunodeficiency (HP:0004430)3.02041308
23Increased IgM level (HP:0003496)2.98636828
24Hepatic necrosis (HP:0002605)2.81723480
25Petechiae (HP:0000967)2.80810599
26Abolished electroretinogram (ERG) (HP:0000550)2.79872186
27Abnormality of B cell number (HP:0010975)2.77422003
28Increased CSF lactate (HP:0002490)2.76030815
29Acute encephalopathy (HP:0006846)2.72942441
30Increased muscle lipid content (HP:0009058)2.71180756
31Progressive macrocephaly (HP:0004481)2.67290874
32Abnormality of T cells (HP:0002843)2.65491599
33Abnormal rod and cone electroretinograms (HP:0008323)2.62766011
34Chronic diarrhea (HP:0002028)2.62408809
35Renal Fanconi syndrome (HP:0001994)2.56129853
36Pancreatic cysts (HP:0001737)2.50447517
37Attenuation of retinal blood vessels (HP:0007843)2.47000717
38Thyroiditis (HP:0100646)2.46280996
39Generalized aminoaciduria (HP:0002909)2.44291521
40Abnormality of midbrain morphology (HP:0002418)2.44153881
41Molar tooth sign on MRI (HP:0002419)2.44153881
42Encephalitis (HP:0002383)2.42681579
43Combined immunodeficiency (HP:0005387)2.41613323
44Prolonged bleeding time (HP:0003010)2.40223612
45B lymphocytopenia (HP:0010976)2.38557519
46Abnormality of eosinophils (HP:0001879)2.38270751
47Purpura (HP:0000979)2.37805091
48Increased hepatocellular lipid droplets (HP:0006565)2.37721940
49Abnormality of macrophages (HP:0004311)2.34422037
50Cerebral edema (HP:0002181)2.33650538
51True hermaphroditism (HP:0010459)2.31102714
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27764919
53Obstructive lung disease (HP:0006536)2.26566761
54Chronic obstructive pulmonary disease (HP:0006510)2.26566761
55Epistaxis (HP:0000421)2.26132079
56Autoimmune thrombocytopenia (HP:0001973)2.22573694
57Increased serum lactate (HP:0002151)2.17331249
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16545344
59Abnormality of alanine metabolism (HP:0010916)2.16545344
60Hyperalaninemia (HP:0003348)2.16545344
61Gangrene (HP:0100758)2.13860570
62Abnormal albumin level (HP:0012116)2.13372839
63Hypoalbuminemia (HP:0003073)2.13372839
64Leukocytosis (HP:0001974)2.11752652
65Lipid accumulation in hepatocytes (HP:0006561)2.10643019
66Exertional dyspnea (HP:0002875)2.08511073
67Pancreatic fibrosis (HP:0100732)2.07768753
68Lactic acidosis (HP:0003128)2.06659125
69Constricted visual fields (HP:0001133)2.06278644
70Type 2 muscle fiber atrophy (HP:0003554)2.05320722
71Severe visual impairment (HP:0001141)2.05250575
72Optic disc pallor (HP:0000543)2.04077088
73Type I transferrin isoform profile (HP:0003642)2.02920118
74Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00857339
75Eosinophilia (HP:0001880)1.99740943
76Lymphopenia (HP:0001888)1.99598332
77Chest pain (HP:0100749)1.98986158
78Pancytopenia (HP:0001876)1.96605031
79Vasculitis (HP:0002633)1.95389151
80Meningitis (HP:0001287)1.95182124
81Myositis (HP:0100614)1.93982541
82Gingival bleeding (HP:0000225)1.93746115
83Type II lissencephaly (HP:0007260)1.93099744
84Abnormality of the renal cortex (HP:0011035)1.85122292
85Pustule (HP:0200039)1.84271024
86Optic neuritis (HP:0100653)1.83072562
87Retrobulbar optic neuritis (HP:0100654)1.83072562
88Hemoptysis (HP:0002105)1.82341121
89Joint swelling (HP:0001386)1.82302760
90Muscle fiber atrophy (HP:0100295)1.82229279
91Lethargy (HP:0001254)1.80925981
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.80668134
93Abnormal drinking behavior (HP:0030082)1.79585071
94Polydipsia (HP:0001959)1.79585071
95Gastrointestinal infarctions (HP:0005244)1.79179378
96Retinal dysplasia (HP:0007973)1.75972851
97Cerebral palsy (HP:0100021)1.74265962
98Abnormality of magnesium homeostasis (HP:0004921)1.74204016
99Hypomagnesemia (HP:0002917)1.73073553
100Panhypogammaglobulinemia (HP:0003139)1.72027653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.40443226
2KDR4.20359029
3TESK23.89869315
4BCKDK3.22414523
5ZAK3.16678508
6TAOK33.00991074
7TLK12.55382785
8ADRBK22.35668049
9MST42.03305021
10MAP4K21.93334973
11MAP4K11.92742279
12ITK1.91267346
13TEC1.89333445
14SYK1.84043616
15GRK11.75047095
16NUAK11.72275691
17GRK71.71057384
18FES1.64004196
19BMPR21.63893171
20MAP3K121.61573854
21CDK191.55040294
22LIMK11.53275164
23PIM21.48240127
24BTK1.47066572
25GRK61.41994522
26PINK11.37306632
27FRK1.35366864
28MAP3K111.32054573
29TESK11.24901226
30KIT1.23538283
31IKBKB1.22338739
32RIPK41.21396762
33MAPKAPK31.18021110
34STK161.17463791
35EIF2AK11.14268753
36PRKCQ1.13103143
37TIE11.12468197
38MYLK1.11464774
39CSK1.09196964
40LYN1.08925045
41MATK1.07362007
42VRK21.07330227
43SCYL21.05270483
44LCK1.03198229
45TNK21.02553184
46CSF1R1.01821357
47ZAP700.97148122
48VRK10.91984956
49MUSK0.90767977
50JAK30.89749879
51CSNK1G30.81807046
52BMPR1B0.81085554
53TBK10.79735256
54IKBKE0.79430232
55WNK30.78574614
56DAPK10.78218726
57GRK50.77417084
58ACVR1B0.75504610
59WNK40.73294069
60RPS6KA50.71649964
61PIM10.71575297
62PIK3CG0.70808447
63ADRBK10.70628486
64INSRR0.67671108
65MAP2K70.67619092
66DAPK20.65019473
67CSNK1A1L0.61881858
68CSNK1G10.58584405
69CSNK1G20.55651335
70OXSR10.54600260
71MAP3K50.52104500
72TYRO30.50790157
73DAPK30.50203980
74MAPK130.49313114
75PAK10.48282975
76PRKCA0.47092715
77EIF2AK30.47028336
78IGF1R0.46574186
79PLK20.46450429
80FYN0.46213484
81TRIM280.44552878
82CAMKK20.43837220
83PIK3CA0.43424451
84RPS6KA40.41689743
85ARAF0.40352745
86MARK30.38826541
87HCK0.38446651
88PRKACA0.37317623
89PTK2B0.36819734
90ROCK10.34744028
91PRKCD0.33253148
92FGR0.33119005
93MAP3K30.32924381
94ABL10.32654523
95DYRK20.32438739
96AURKA0.30909869
97CAMK2A0.30049845
98INSR0.29819487
99BMX0.28292350
100MAP2K60.27873937

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.04354846
2Graft-versus-host disease_Homo sapiens_hsa053323.95007635
3Allograft rejection_Homo sapiens_hsa053303.66799891
4Autoimmune thyroid disease_Homo sapiens_hsa053203.59440280
5Asthma_Homo sapiens_hsa053103.18506042
6Proteasome_Homo sapiens_hsa030502.98310338
7Type I diabetes mellitus_Homo sapiens_hsa049402.94979084
8Antigen processing and presentation_Homo sapiens_hsa046122.94761430
9Oxidative phosphorylation_Homo sapiens_hsa001902.65696595
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.60827227
11Hematopoietic cell lineage_Homo sapiens_hsa046402.54331420
12Rheumatoid arthritis_Homo sapiens_hsa053232.43504002
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17012689
14Parkinsons disease_Homo sapiens_hsa050122.09069440
15Phototransduction_Homo sapiens_hsa047441.77070815
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75735327
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64474261
18Staphylococcus aureus infection_Homo sapiens_hsa051501.58736727
19Viral myocarditis_Homo sapiens_hsa054161.58139017
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55403832
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39890698
22Linoleic acid metabolism_Homo sapiens_hsa005911.37805594
23Nitrogen metabolism_Homo sapiens_hsa009101.34447136
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.33922091
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33731699
26Collecting duct acid secretion_Homo sapiens_hsa049661.30505269
27T cell receptor signaling pathway_Homo sapiens_hsa046601.28757305
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26927991
29Alzheimers disease_Homo sapiens_hsa050101.23220470
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22298804
31RNA polymerase_Homo sapiens_hsa030201.07284336
32Arachidonic acid metabolism_Homo sapiens_hsa005901.04950482
33Huntingtons disease_Homo sapiens_hsa050161.03585421
34Ribosome_Homo sapiens_hsa030101.03427333
35Systemic lupus erythematosus_Homo sapiens_hsa053221.03301755
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98523886
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97240471
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.97172601
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96491163
40Cardiac muscle contraction_Homo sapiens_hsa042600.96079017
41Leishmaniasis_Homo sapiens_hsa051400.94021730
42Protein export_Homo sapiens_hsa030600.92677101
43Malaria_Homo sapiens_hsa051440.91486729
44Olfactory transduction_Homo sapiens_hsa047400.87687942
45Salmonella infection_Homo sapiens_hsa051320.86025168
46Caffeine metabolism_Homo sapiens_hsa002320.84650283
47Measles_Homo sapiens_hsa051620.82061031
48Sulfur metabolism_Homo sapiens_hsa009200.78192454
49Peroxisome_Homo sapiens_hsa041460.77449600
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72674833
51Ether lipid metabolism_Homo sapiens_hsa005650.71300932
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70927246
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.70371421
54Chemical carcinogenesis_Homo sapiens_hsa052040.68340651
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65717503
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65528046
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65371507
58Herpes simplex infection_Homo sapiens_hsa051680.64795384
59Retinol metabolism_Homo sapiens_hsa008300.64776901
60Shigellosis_Homo sapiens_hsa051310.63782051
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63624549
62Regulation of autophagy_Homo sapiens_hsa041400.61675464
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.60672173
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57264590
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56241662
66Phagosome_Homo sapiens_hsa041450.54221470
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54152539
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53686635
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53626375
70Legionellosis_Homo sapiens_hsa051340.53029498
71Tuberculosis_Homo sapiens_hsa051520.52259243
72Pyrimidine metabolism_Homo sapiens_hsa002400.51640510
73Tryptophan metabolism_Homo sapiens_hsa003800.49508399
74Chemokine signaling pathway_Homo sapiens_hsa040620.48990319
75Platelet activation_Homo sapiens_hsa046110.48340955
76One carbon pool by folate_Homo sapiens_hsa006700.47871933
77Fat digestion and absorption_Homo sapiens_hsa049750.44627100
78Pertussis_Homo sapiens_hsa051330.43253367
79Purine metabolism_Homo sapiens_hsa002300.42610444
80Butanoate metabolism_Homo sapiens_hsa006500.39745923
81Morphine addiction_Homo sapiens_hsa050320.37628212
82Metabolic pathways_Homo sapiens_hsa011000.32694930
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.32152942
84Lysosome_Homo sapiens_hsa041420.32120187
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31495197
86Influenza A_Homo sapiens_hsa051640.31037983
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.30200750
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.30117097
89RNA degradation_Homo sapiens_hsa030180.29963723
90Serotonergic synapse_Homo sapiens_hsa047260.29590702
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.29193666
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28892634
93Mineral absorption_Homo sapiens_hsa049780.28584034
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28009887
95Epstein-Barr virus infection_Homo sapiens_hsa051690.27405716
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26850968
97Taste transduction_Homo sapiens_hsa047420.26808915
98Propanoate metabolism_Homo sapiens_hsa006400.24493835
99African trypanosomiasis_Homo sapiens_hsa051430.24220671
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23204211

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