FTH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.24131905
2positive regulation by symbiont of host defense response (GO:0052509)5.66752619
3modulation by symbiont of host defense response (GO:0052031)5.66752619
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.66752619
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.66752619
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.66752619
7modulation by symbiont of host immune response (GO:0052553)5.66752619
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.85571483
9respiratory burst (GO:0045730)4.72103834
10negative regulation of interleukin-12 production (GO:0032695)4.68872506
11response to peptidoglycan (GO:0032494)4.68246209
12hydrogen peroxide biosynthetic process (GO:0050665)4.55299032
13positive regulation of chemokine biosynthetic process (GO:0045080)4.50181909
14granulocyte activation (GO:0036230)4.30535881
15lipopolysaccharide-mediated signaling pathway (GO:0031663)4.30379522
16positive regulation of interferon-alpha production (GO:0032727)4.27641578
17macrophage activation involved in immune response (GO:0002281)4.19719989
18immunoglobulin mediated immune response (GO:0016064)4.16775064
19regulation of vitamin D biosynthetic process (GO:0060556)4.09530331
20regulation of interferon-alpha production (GO:0032647)4.07933483
21neutrophil activation (GO:0042119)4.01133714
22reactive oxygen species biosynthetic process (GO:1903409)3.97593783
23cellular response to thyroid hormone stimulus (GO:0097067)3.96751572
24positive regulation of heat generation (GO:0031652)3.85095278
25glycosphingolipid catabolic process (GO:0046479)3.79160283
26superoxide anion generation (GO:0042554)3.77091132
27response to host immune response (GO:0052572)3.76016197
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.76016197
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.74737162
30NIK/NF-kappaB signaling (GO:0038061)3.70838628
31regulation of interferon-beta biosynthetic process (GO:0045357)3.68150541
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.66946309
33regulation of chemokine biosynthetic process (GO:0045073)3.65271983
34regulation of fever generation (GO:0031620)3.62736152
35regulation of mononuclear cell migration (GO:0071675)3.60160904
36myeloid cell activation involved in immune response (GO:0002275)3.59631549
37positive regulation of mast cell degranulation (GO:0043306)3.55049162
38positive regulation of mast cell activation involved in immune response (GO:0033008)3.55049162
39phagosome maturation (GO:0090382)3.47753200
40regulation of vitamin metabolic process (GO:0030656)3.45355863
41glycolipid catabolic process (GO:0019377)3.41154323
42eosinophil chemotaxis (GO:0048245)3.40445033
43lymphocyte chemotaxis (GO:0048247)3.39464552
44oligosaccharide catabolic process (GO:0009313)3.35127789
45natural killer cell mediated immunity (GO:0002228)3.30154838
46natural killer cell mediated cytotoxicity (GO:0042267)3.30154838
47positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.30146921
48positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.29291641
49positive regulation of mast cell activation (GO:0033005)3.27834694
50microglial cell activation (GO:0001774)3.27353318
51response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26512641
52response to host (GO:0075136)3.26512641
53response to host defenses (GO:0052200)3.26512641
54positive regulation of leukocyte degranulation (GO:0043302)3.25753317
55T-helper 1 type immune response (GO:0042088)3.22985865
56positive regulation of cellular amide metabolic process (GO:0034250)3.22817131
57response to thyroid hormone (GO:0097066)3.20668920
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.19523128
59type I interferon signaling pathway (GO:0060337)3.19040097
60cellular response to type I interferon (GO:0071357)3.19040097
61barbed-end actin filament capping (GO:0051016)3.18649750
62negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.18416583
63regulation of cytokine secretion involved in immune response (GO:0002739)3.18140826
64macrophage activation (GO:0042116)3.16067866
65response to type I interferon (GO:0034340)3.13100099
66leukocyte aggregation (GO:0070486)3.12971892
67amino sugar catabolic process (GO:0046348)3.10943114
68negative regulation of nitric oxide biosynthetic process (GO:0045019)3.09770371
69regulation of heat generation (GO:0031650)3.07866387
70eosinophil migration (GO:0072677)3.07508680
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.06207606
72negative regulation of myeloid cell apoptotic process (GO:0033033)3.04603469
73defense response to protozoan (GO:0042832)3.03722375
74regulation of mast cell degranulation (GO:0043304)3.01081348
75regulation of superoxide anion generation (GO:0032928)3.00695790
76regulation of podosome assembly (GO:0071801)3.00459153
77regulation of T-helper 1 cell differentiation (GO:0045625)2.99426676
78monocyte chemotaxis (GO:0002548)2.99298925
79positive regulation of toll-like receptor signaling pathway (GO:0034123)2.98270695
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.98209548
81ceramide catabolic process (GO:0046514)2.98086677
82production of molecular mediator involved in inflammatory response (GO:0002532)2.96896917
83response to muramyl dipeptide (GO:0032495)2.95736626
84response to protozoan (GO:0001562)2.95007430
85negative regulation of erythrocyte differentiation (GO:0045647)2.94465365
86protein localization to endosome (GO:0036010)2.93003193
87germinal center formation (GO:0002467)2.92593612
88negative regulation of cytokine production involved in immune response (GO:0002719)2.92558938
89negative regulation of interleukin-17 production (GO:0032700)2.90799356
90low-density lipoprotein particle clearance (GO:0034383)2.90575690
91regulation of membrane protein ectodomain proteolysis (GO:0051043)2.89671226
92cyclooxygenase pathway (GO:0019371)2.87639402
93positive regulation of gamma-delta T cell activation (GO:0046645)2.85910246
94positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.83573652
95interferon-gamma-mediated signaling pathway (GO:0060333)2.83443815
96B cell mediated immunity (GO:0019724)2.82607351
97positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.82242387
98positive regulation of interferon-beta production (GO:0032728)2.81924406
99regulation of T-helper 2 cell differentiation (GO:0045628)2.81707650
100positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81465134
101regulation of early endosome to late endosome transport (GO:2000641)2.80584745
102response to interferon-alpha (GO:0035455)2.80426679
103positive regulation of antigen processing and presentation (GO:0002579)2.79789637
104cellular response to arsenic-containing substance (GO:0071243)2.78246676
105negative regulation of viral genome replication (GO:0045071)2.77820821
106negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.77358987
107regulation of leukocyte degranulation (GO:0043300)2.77043495
108leukocyte mediated cytotoxicity (GO:0001909)2.77009950
109myeloid leukocyte activation (GO:0002274)2.76693124
110regulation of mast cell activation involved in immune response (GO:0033006)2.76659153
111leukocyte degranulation (GO:0043299)2.76598752
112positive regulation of monocyte chemotaxis (GO:0090026)2.75444003
113regulation of cholesterol storage (GO:0010885)2.74905595
114positive regulation of lymphocyte migration (GO:2000403)2.74866994
115positive regulation of acute inflammatory response (GO:0002675)2.74720449
116positive regulation of chemokine production (GO:0032722)2.73861021
117cellular response to lipopolysaccharide (GO:0071222)2.73546893
118positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.73516231
119regulation of interleukin-17 production (GO:0032660)2.73395582
120regulation of macrophage chemotaxis (GO:0010758)2.72904901
121regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72237159
122response to lipoprotein particle (GO:0055094)2.72177865
123N-acetylneuraminate metabolic process (GO:0006054)2.70561024
124decidualization (GO:0046697)2.70053302
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.69803622
126membrane lipid catabolic process (GO:0046466)2.69225878
127regulation of mast cell activation (GO:0033003)2.69138492
128myeloid dendritic cell differentiation (GO:0043011)2.68850088
129positive regulation of type 2 immune response (GO:0002830)2.68820322
130negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.68753575
131detection of molecule of bacterial origin (GO:0032490)2.66911519
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66729572
133positive regulation of NF-kappaB import into nucleus (GO:0042346)2.66495270
134cellular response to molecule of bacterial origin (GO:0071219)2.65885144
135regulation of interleukin-8 biosynthetic process (GO:0045414)2.65215865
136regulation of heterotypic cell-cell adhesion (GO:0034114)2.65161476
137regulation of lymphocyte migration (GO:2000401)2.64497793
138neutrophil chemotaxis (GO:0030593)2.64041212
139regulation of antigen processing and presentation (GO:0002577)2.62332850
140pinocytosis (GO:0006907)2.61560181
141negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.60907402
142negative regulation of cell killing (GO:0031342)2.60907402
143mature B cell differentiation involved in immune response (GO:0002313)2.59436942
144myeloid dendritic cell activation (GO:0001773)2.59000315
145dendritic cell differentiation (GO:0097028)2.58923774
146adhesion of symbiont to host cell (GO:0044650)2.58194904
147virion attachment to host cell (GO:0019062)2.58194904
148regulation of monocyte chemotaxis (GO:0090025)2.57781392
149regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.56880155
150sphingolipid catabolic process (GO:0030149)2.55737341
151regulation of myeloid leukocyte mediated immunity (GO:0002886)2.55332086
152positive regulation of interleukin-6 production (GO:0032755)2.55018262
153positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.54833944
154regulation of interleukin-12 production (GO:0032655)2.54263985

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.80979331
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.31744557
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.99080812
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.28715170
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.96075742
6* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.86980492
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56065603
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.51157636
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.25440583
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.08463735
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65955544
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.64166209
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.36413492
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36192378
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12747608
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11059862
17LXR_22292898_ChIP-Seq_THP-1_Human2.08826199
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.03999077
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.96572329
20* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90473903
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88455474
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77488920
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.75652415
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.71887617
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.69802308
26* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68482650
27VDR_24787735_ChIP-Seq_THP-1_Human1.67872572
28* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63931410
29TRIM28_21343339_ChIP-Seq_HEK293_Human1.63845975
30ZNF263_19887448_ChIP-Seq_K562_Human1.60998978
31CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60467577
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56170501
33* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54092841
34* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53155729
35* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53155729
36SPI1_23547873_ChIP-Seq_NB4_Human1.52807184
37VDR_24763502_ChIP-Seq_THP-1_Human1.50985293
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50293726
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49484786
40SPI1_23127762_ChIP-Seq_K562_Human1.49044213
41* PU_27001747_Chip-Seq_BMDM_Mouse1.43291686
42* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43182576
43* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41213015
44RACK7_27058665_Chip-Seq_MCF-7_Human1.40190394
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39406129
46KDM2B_26808549_Chip-Seq_DND41_Human1.38720756
47CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37972276
48* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37012200
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.35590819
50RUNX_20019798_ChIP-Seq_JUKART_Human1.34905345
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33244473
52TCF7_22412390_ChIP-Seq_EML_Mouse1.31917644
53* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31882743
54* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.30931050
55TFEB_21752829_ChIP-Seq_HELA_Human1.30818075
56* RUNX1_22412390_ChIP-Seq_EML_Mouse1.30147517
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28744119
58* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28310958
59* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25076398
60* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23997128
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23947830
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23717910
63EGR1_19032775_ChIP-ChIP_M12_Human1.22329060
64CLOCK_20551151_ChIP-Seq_293T_Human1.22256276
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22250122
66* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.22155188
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21890471
68SOX2_20726797_ChIP-Seq_SW620_Human1.21694840
69MYC_22102868_ChIP-Seq_BL_Human1.20045603
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19035669
71* UTX_26944678_Chip-Seq_JUKART_Human1.17010205
72BCL6_27268052_Chip-Seq_Bcells_Human1.15239591
73RXR_22158963_ChIP-Seq_LIVER_Mouse1.14446224
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.13015441
75CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11816914
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11535081
77BCOR_27268052_Chip-Seq_Bcells_Human1.11037425
78ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10929047
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10852908
80* NCOR1_26117541_ChIP-Seq_K562_Human1.09241925
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.09002548
82SCL_19346495_ChIP-Seq_HPC-7_Human1.08413306
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07942042
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07579002
85* MAF_26560356_Chip-Seq_TH2_Human1.07081427
86TP63_17297297_ChIP-ChIP_HaCaT_Human1.06977488
87MYB_26560356_Chip-Seq_TH2_Human1.05994097
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04336899
89* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03803833
90KDM2B_26808549_Chip-Seq_K562_Human1.03252612
91* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.02718351
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02493891
93PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01269121
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01125869
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00021738
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99968844
97GATA3_26560356_Chip-Seq_TH2_Human0.97747025
98* GATA1_19941826_ChIP-Seq_K562_Human0.97640471
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96900169
100MAF_26560356_Chip-Seq_TH1_Human0.95058806
101JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95054996
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94666254
103P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94644759
104* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94568309
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92568687
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92271055
107GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91841901
108* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91432845
109* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91337808
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87336574
111CJUN_26792858_Chip-Seq_BT549_Human0.87244794
112SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85494933
113* GATA3_27048872_Chip-Seq_THYMUS_Human0.84148829
114* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83685581
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83636796
116ESR2_21235772_ChIP-Seq_MCF-7_Human0.82296960
117E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.81862105
118PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81833470
119ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81240051
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.79940073
121* GATA2_19941826_ChIP-Seq_K562_Human0.79713802
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.76875925
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.74148389
124* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.72503226
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70857069
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70631954
127GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70189092
128VDR_21846776_ChIP-Seq_THP-1_Human0.69296318
129SPI1_20517297_ChIP-Seq_HL60_Human0.68940951
130STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68739711
131* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66977982
132FOXO3_23340844_ChIP-Seq_DLD1_Human0.66380403
133STAT1_20625510_ChIP-Seq_HELA_Human0.65894321
134SALL4_18804426_ChIP-ChIP_XEN_Mouse0.65838627
135PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.65150021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006082_CNS_inflammation3.86957962
2MP0001835_abnormal_antigen_presentation3.67805971
3MP0005058_abnormal_lysosome_morphology3.55905912
4MP0003436_decreased_susceptibility_to3.55513198
5MP0009785_altered_susceptibility_to3.54456783
6MP0003303_peritoneal_inflammation3.46619705
7MP0002148_abnormal_hypersensitivity_rea3.42223004
8MP0003724_increased_susceptibility_to3.30321783
9MP0002419_abnormal_innate_immunity3.13149999
10MP0005000_abnormal_immune_tolerance3.03919815
11MP0005025_abnormal_response_to2.75914296
12MP0003806_abnormal_nucleotide_metabolis2.72397650
13MP0004510_myositis2.72091477
14MP0005387_immune_system_phenotype2.43491807
15MP0001790_abnormal_immune_system2.43491807
16MP0000920_abnormal_myelination2.36881937
17MP0001533_abnormal_skeleton_physiology2.34545172
18MP0003075_altered_response_to2.33943754
19MP0003690_abnormal_glial_cell2.23848960
20MP0002452_abnormal_antigen_presenting2.21379020
21MP0002723_abnormal_immune_serum2.14910860
22MP0003172_abnormal_lysosome_physiology2.14866931
23MP0000604_amyloidosis2.12018586
24MP0009840_abnormal_foam_cell2.08985694
25MP0000685_abnormal_immune_system2.06340168
26MP0000343_altered_response_to2.05188510
27MP0005167_abnormal_blood-brain_barrier1.99070233
28MP0003195_calcinosis1.98320776
29MP0009764_decreased_sensitivity_to1.96408662
30MP0005671_abnormal_response_to1.93144060
31MP0002139_abnormal_hepatobiliary_system1.89699488
32MP0005464_abnormal_platelet_physiology1.87148699
33MP0002877_abnormal_melanocyte_morpholog1.86756714
34MP0001800_abnormal_humoral_immune1.86739886
35MP0003448_altered_tumor_morphology1.82034695
36MP0004947_skin_inflammation1.80149086
37MP0001819_abnormal_immune_cell1.79894227
38MP0002998_abnormal_bone_remodeling1.76364501
39MP0002420_abnormal_adaptive_immunity1.76237551
40MP0008004_abnormal_stomach_pH1.73167938
41MP0003191_abnormal_cellular_cholesterol1.68064427
42* MP0001845_abnormal_inflammatory_respons1.63794511
43MP0005164_abnormal_response_to1.58191817
44MP0005166_decreased_susceptibility_to1.56964369
45MP0004858_abnormal_nervous_system1.56003009
46* MP0008469_abnormal_protein_level1.54288690
47MP0002405_respiratory_system_inflammati1.53315211
48MP0005310_abnormal_salivary_gland1.50409102
49MP0001853_heart_inflammation1.48515475
50MP0006054_spinal_hemorrhage1.43817832
51* MP0003186_abnormal_redox_activity1.37495310
52MP0003950_abnormal_plasma_membrane1.36799704
53MP0009278_abnormal_bone_marrow1.36574027
54MP0008260_abnormal_autophagy1.33209204
55MP0003329_amyloid_beta_deposits1.32255864
56MP0003656_abnormal_erythrocyte_physiolo1.31461400
57MP0010155_abnormal_intestine_physiology1.24048474
58MP0000858_altered_metastatic_potential1.23269117
59MP0001851_eye_inflammation1.20736173
60MP0003300_gastrointestinal_ulcer1.18232888
61MP0002006_tumorigenesis1.15201559
62MP0009333_abnormal_splenocyte_physiolog1.13604554
63MP0000716_abnormal_immune_system1.11904791
64MP0008438_abnormal_cutaneous_collagen1.11770833
65MP0002933_joint_inflammation1.09402926
66MP0003634_abnormal_glial_cell1.08078166
67MP0005390_skeleton_phenotype1.03729204
68MP0001958_emphysema1.00783404
69MP0004782_abnormal_surfactant_physiolog0.96773165
70MP0002277_abnormal_respiratory_mucosa0.95111820
71MP0009765_abnormal_xenobiotic_induced0.93423785
72MP0002254_reproductive_system_inflammat0.93238459
73MP0005451_abnormal_body_composition0.91206648
74MP0005083_abnormal_biliary_tract0.90563927
75MP0005171_absent_coat_pigmentation0.90099235
76MP0002332_abnormal_exercise_endurance0.88746490
77MP0001501_abnormal_sleep_pattern0.88235013
78MP0008874_decreased_physiological_sensi0.87270975
79MP0003453_abnormal_keratinocyte_physiol0.87241506
80MP0003279_aneurysm0.87228902
81MP0000465_gastrointestinal_hemorrhage0.86120251
82MP0005397_hematopoietic_system_phenotyp0.85241667
83MP0001545_abnormal_hematopoietic_system0.85241667
84MP0002398_abnormal_bone_marrow0.83680841
85MP0000371_diluted_coat_color0.82888842
86MP0002429_abnormal_blood_cell0.82644357
87MP0003828_pulmonary_edema0.80866863
88MP0004883_abnormal_blood_vessel0.80608320
89MP0003705_abnormal_hypodermis_morpholog0.80178913
90MP0001849_ear_inflammation0.79773991
91MP0002090_abnormal_vision0.79346499
92* MP0009763_increased_sensitivity_to0.79198817
93MP0003633_abnormal_nervous_system0.78724933
94MP0000249_abnormal_blood_vessel0.78333635
95MP0005165_increased_susceptibility_to0.75160188
96MP0005584_abnormal_enzyme/coenzyme_acti0.75109176
97MP0002295_abnormal_pulmonary_circulatio0.73013344
98MP0005257_abnormal_intraocular_pressure0.70773969
99MP0004233_abnormal_muscle_weight0.68454447
100* MP0000689_abnormal_spleen_morphology0.68386037
101MP0003795_abnormal_bone_structure0.67919860
102MP0005535_abnormal_body_temperature0.66565291
103MP0005076_abnormal_cell_differentiation0.66399589
104MP0002136_abnormal_kidney_physiology0.66116516
105MP0005595_abnormal_vascular_smooth0.64665742
106MP0008873_increased_physiological_sensi0.64067164
107MP0003183_abnormal_peptide_metabolism0.62202505
108MP0003091_abnormal_cell_migration0.61310899
109MP0002722_abnormal_immune_system0.60948764
110MP0001542_abnormal_bone_strength0.60430843
111MP0010307_abnormal_tumor_latency0.57900974
112MP0003566_abnormal_cell_adhesion0.57730850
113MP0000015_abnormal_ear_pigmentation0.57251697
114MP0003631_nervous_system_phenotype0.56402624
115MP0010386_abnormal_urinary_bladder0.56366925
116MP0001663_abnormal_digestive_system0.53913621
117MP0005647_abnormal_sex_gland0.52211229
118MP0003136_yellow_coat_color0.50900276
119MP0005023_abnormal_wound_healing0.50018306

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.91835545
2Eczematoid dermatitis (HP:0000976)6.91495730
3Recurrent bacterial skin infections (HP:0005406)6.39161536
4Recurrent gram-negative bacterial infections (HP:0005420)5.97450475
5Abnormality of macrophages (HP:0004311)5.73656446
6Axonal loss (HP:0003447)5.26956799
7Increased cerebral lipofuscin (HP:0011813)5.07931833
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.73886390
9Vacuolated lymphocytes (HP:0001922)4.53493715
10Mediastinal lymphadenopathy (HP:0100721)4.53300835
11Stomatitis (HP:0010280)4.41462627
12Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.23722273
13Elevated erythrocyte sedimentation rate (HP:0003565)4.02417024
14Recurrent skin infections (HP:0001581)3.96940483
15Systemic lupus erythematosus (HP:0002725)3.92657293
16Autoimmune thrombocytopenia (HP:0001973)3.87656150
17Chronic obstructive pulmonary disease (HP:0006510)3.76511315
18Obstructive lung disease (HP:0006536)3.76511315
19Gingivitis (HP:0000230)3.76189328
20Neurofibrillary tangles (HP:0002185)3.73906289
21Abnormality of liposaccharide metabolism (HP:0010968)3.69962315
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.69962315
23Abnormality of glycolipid metabolism (HP:0010969)3.69962315
24Dysostosis multiplex (HP:0000943)3.46587674
25Nuclear cataract (HP:0100018)3.35471456
26Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.32415639
27Disinhibition (HP:0000734)3.26612047
28Interstitial pulmonary disease (HP:0006530)3.23599984
29Hepatosplenomegaly (HP:0001433)3.19922070
30Orchitis (HP:0100796)3.17051608
31Supranuclear gaze palsy (HP:0000605)3.08530079
32Loss of speech (HP:0002371)3.04418013
33Myositis (HP:0100614)3.04038970
34Urticaria (HP:0001025)3.03710864
35Segmental peripheral demyelination/remyelination (HP:0003481)2.96465230
36Cellulitis (HP:0100658)2.95709357
37Vasculitis (HP:0002633)2.92093155
38Tetraparesis (HP:0002273)2.90062688
39Recurrent fungal infections (HP:0002841)2.89386172
40Parakeratosis (HP:0001036)2.83350772
41Basal ganglia calcification (HP:0002135)2.83230141
42Optic neuritis (HP:0100653)2.79864690
43Retrobulbar optic neuritis (HP:0100654)2.79864690
44Urinary glycosaminoglycan excretion (HP:0003541)2.69797365
45Mucopolysacchariduria (HP:0008155)2.69797365
46Cerebral inclusion bodies (HP:0100314)2.64243738
47Thick nail (HP:0001805)2.59260200
48Poor head control (HP:0002421)2.54953914
49Glomerulonephritis (HP:0000099)2.54820705
50Prostate neoplasm (HP:0100787)2.54618399
51Increased IgM level (HP:0003496)2.52710024
52Upper motor neuron abnormality (HP:0002127)2.49761575
53Recurrent pneumonia (HP:0006532)2.49071185
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.46535404
55Abnormality of polysaccharide metabolism (HP:0011012)2.46535404
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.46535404
57Peripheral demyelination (HP:0011096)2.42590035
58Vertebral compression fractures (HP:0002953)2.36990336
59* Increased serum ferritin (HP:0003281)2.35304853
60Recurrent viral infections (HP:0004429)2.31437248
61Amyloidosis (HP:0011034)2.31225951
62Chronic otitis media (HP:0000389)2.29950959
63Pustule (HP:0200039)2.26973844
64Myocardial infarction (HP:0001658)2.24897161
65Osteolytic defects of the phalanges of the hand (HP:0009771)2.23317229
66Osteolytic defects of the hand bones (HP:0009699)2.23317229
67Osteomyelitis (HP:0002754)2.20466124
68Pathologic fracture (HP:0002756)2.19877445
69Bone pain (HP:0002653)2.17472994
70Recurrent lower respiratory tract infections (HP:0002783)2.16798072
71Dementia (HP:0000726)2.15357268
72Hypergammaglobulinemia (HP:0010702)2.15088367
73Petechiae (HP:0000967)2.14320870
74Complement deficiency (HP:0004431)2.14150482
75Prolonged neonatal jaundice (HP:0006579)2.14006660
76Purpura (HP:0000979)2.12727614
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12420671
78Personality changes (HP:0000751)2.11260991
79Slow saccadic eye movements (HP:0000514)2.10563967
80Spastic tetraparesis (HP:0001285)2.07392824
81Esophageal neoplasm (HP:0100751)2.06660517
82Neoplasm of head and neck (HP:0012288)2.06660517
83Metaphyseal irregularity (HP:0003025)2.06474843
84Chronic mucocutaneous candidiasis (HP:0002728)2.04510853
85Recurrent cutaneous fungal infections (HP:0011370)2.04510853
86Apathy (HP:0000741)2.03198957
87Abnormality of complement system (HP:0005339)2.02374358
88Periodontitis (HP:0000704)2.01407087
89Hypertensive crisis (HP:0100735)2.01195515
90Peritonitis (HP:0002586)2.00318909
91Diminished motivation (HP:0000745)1.99380822
92Pulmonary infiltrates (HP:0002113)1.97173297
93Progressive visual loss (HP:0000529)1.95148950
94Asymmetric septal hypertrophy (HP:0001670)1.94531528
95Premature loss of primary teeth (HP:0006323)1.93818780
96J-shaped sella turcica (HP:0002680)1.93457557
97Meningitis (HP:0001287)1.93142476
98Spontaneous hematomas (HP:0007420)1.92433609
99Clumsiness (HP:0002312)1.90043022
100Nephritis (HP:0000123)1.89558167
101Mutism (HP:0002300)1.88617892
102Abnormal gallbladder physiology (HP:0012438)1.88198457
103Cholecystitis (HP:0001082)1.88198457
104Leukocytosis (HP:0001974)1.87542106
105Cerebral hemorrhage (HP:0001342)1.87270557
106Epistaxis (HP:0000421)1.86515654
107Hematochezia (HP:0002573)1.85483687
108Prolonged bleeding time (HP:0003010)1.84744817
109Gingival bleeding (HP:0000225)1.83960443
110Juvenile onset (HP:0003621)1.83451452
111Inappropriate behavior (HP:0000719)1.83237575
112Neuronal loss in central nervous system (HP:0002529)1.81826337
113Hemoptysis (HP:0002105)1.81516073
114Nausea (HP:0002018)1.80957220
115* Abnormality of iron homeostasis (HP:0011031)1.80781596
116Abnormality of the nasal mucosa (HP:0000433)1.80471451
117Onion bulb formation (HP:0003383)1.80291711
118Agnosia (HP:0010524)1.79014901
119Progressive neurologic deterioration (HP:0002344)1.78837604
120Polycythemia (HP:0001901)1.78420161
121Achilles tendon contracture (HP:0001771)1.75627473
122Malnutrition (HP:0004395)1.74755471
123Conjunctival telangiectasia (HP:0000524)1.73246726
124Cervical subluxation (HP:0003308)1.73221991
125Gastrointestinal infarctions (HP:0005244)1.73114319
126Hyperparathyroidism (HP:0000843)1.72946811
127Cardiomegaly (HP:0001640)1.72617468
128Thin bony cortex (HP:0002753)1.71423202
129Keratoconjunctivitis sicca (HP:0001097)1.71365146
130Thoracic kyphosis (HP:0002942)1.71312350
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.71296549
132Polyneuropathy (HP:0001271)1.71126834
133Spondylolisthesis (HP:0003302)1.70183104
134Retinal atrophy (HP:0001105)1.67490330

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK5.95867876
2RIPK44.57546064
3MAP3K143.40444778
4TBK13.24897653
5BLK3.17407155
6TAOK22.58847664
7EPHB12.58576058
8IKBKE2.51811566
9DDR22.46311068
10ERN12.24770791
11IRAK42.14627702
12IRAK32.10895065
13MAP3K32.05846479
14TYK22.02789008
15PRPF4B1.90156042
16BMX1.85126587
17ARAF1.84964651
18MAP3K131.84844845
19IKBKB1.82023551
20TAOK11.80169219
21PIM21.79243876
22KIT1.68948624
23FGR1.62954903
24MAP4K11.60186086
25ABL21.58472740
26MAP2K31.57630621
27MST41.53256967
28SIK31.43501857
29KSR21.38439998
30JAK11.36322212
31JAK31.36058382
32NME21.34342306
33MST1R1.34254026
34TXK1.33750228
35STK391.33571683
36CSK1.28457360
37MAPKAPK51.28208673
38CDC42BPA1.27869011
39BMPR21.15292944
40SIK11.08737848
41MET1.07907219
42HCK1.07429598
43TESK21.06744849
44SYK1.05851142
45PAK41.03039833
46TESK10.97101403
47LIMK10.95927213
48LYN0.94352474
49CLK10.94322842
50SCYL20.93322317
51MAP3K10.91943175
52MATK0.91447033
53MOS0.91056423
54PKN10.87963868
55OXSR10.87961881
56ZAP700.86278021
57JAK20.85527389
58MAP3K110.84003097
59LCK0.83714763
60MARK30.83385939
61CHUK0.83279364
62CSF1R0.79390252
63LATS20.78592500
64DAPK30.78588149
65GRK70.77862459
66NTRK10.73805692
67LRRK20.72578096
68PRKCD0.71696696
69PDPK10.71396499
70PDGFRA0.70411399
71ABL10.70204197
72PDK20.66889675
73STK40.66855897
74RIPK10.66552652
75NEK90.64693888
76TRPM70.64659330
77FES0.64627572
78EGFR0.64602068
79RPS6KA40.63392424
80ADRBK20.62282923
81LMTK20.60715851
82GRK60.60666730
83IRAK20.60261236
84ICK0.58889509
85TRIB30.58026680
86MAP3K20.55744222
87BCKDK0.55447876
88IRAK10.55222969
89BTK0.54932716
90EPHA30.54207776
91MAP2K20.52314491
92PIM10.51362475
93FYN0.51098439
94TTN0.51023286
95PRKCQ0.50928163
96PRKD20.50043068
97STK100.48723767
98PRKG20.48081118
99CAMKK20.48077531
100ERBB40.47434495
101MAPKAPK20.46246999
102PDK10.46107756
103BCR0.45309207
104EPHA20.44606623
105MAPKAPK30.43928913
106EPHB20.43256057
107SIK20.40719422
108WNK40.40243401
109TGFBR20.39310213
110MAPK40.39302940
111FGFR40.37729059
112DYRK30.37568498
113TYRO30.37353728
114BMPR1B0.37329328
115MAP3K90.37187271
116RPS6KL10.37140522
117RPS6KC10.37140522
118MAP3K50.36494084
119WNK10.36418601
120ACVR1B0.35576754
121PRKCE0.35054359
122PRKD10.34692463
123MAP3K80.34546015
124RPS6KA50.34287530
125KDR0.34270780
126BRAF0.33603437
127RPS6KA20.33353709
128PRKCH0.33282259
129TAOK30.32730449
130PTK2B0.31988915
131MARK20.31205183
132DAPK20.30993561
133PAK60.30657950
134PAK10.28614552
135SRC0.28181180
136GSK3A0.28001248
137CAMK2D0.27801609
138CAMK2G0.24206695
139PLK20.23489531

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.30588732
2Graft-versus-host disease_Homo sapiens_hsa053323.18596059
3Staphylococcus aureus infection_Homo sapiens_hsa051502.90060952
4Rheumatoid arthritis_Homo sapiens_hsa053232.83154792
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.75149561
6Lysosome_Homo sapiens_hsa041422.57971840
7Malaria_Homo sapiens_hsa051442.47078048
8Pertussis_Homo sapiens_hsa051332.45775013
9Legionellosis_Homo sapiens_hsa051342.32706006
10Tuberculosis_Homo sapiens_hsa051522.31387854
11Osteoclast differentiation_Homo sapiens_hsa043802.23493323
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.22374312
13Phagosome_Homo sapiens_hsa041452.19692450
14Salmonella infection_Homo sapiens_hsa051322.19295848
15Asthma_Homo sapiens_hsa053102.13135280
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.09142935
17Allograft rejection_Homo sapiens_hsa053301.99038648
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.93796344
19Collecting duct acid secretion_Homo sapiens_hsa049661.79004637
20Type I diabetes mellitus_Homo sapiens_hsa049401.78740458
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.76064772
22African trypanosomiasis_Homo sapiens_hsa051431.72657311
23Steroid biosynthesis_Homo sapiens_hsa001001.71346905
24TNF signaling pathway_Homo sapiens_hsa046681.70503880
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68461866
26Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.47113519
27Measles_Homo sapiens_hsa051621.46554268
28Influenza A_Homo sapiens_hsa051641.43275795
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43163612
30Bladder cancer_Homo sapiens_hsa052191.37742688
31Chemokine signaling pathway_Homo sapiens_hsa040621.37202234
32Glycosaminoglycan degradation_Homo sapiens_hsa005311.36840566
33Shigellosis_Homo sapiens_hsa051311.34086358
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.26906185
35Prion diseases_Homo sapiens_hsa050201.25364886
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23887336
37B cell receptor signaling pathway_Homo sapiens_hsa046621.23329552
38Hematopoietic cell lineage_Homo sapiens_hsa046401.22597493
39Toxoplasmosis_Homo sapiens_hsa051451.19982288
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13718488
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.12366074
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10926900
43Other glycan degradation_Homo sapiens_hsa005111.05169163
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04781242
45Apoptosis_Homo sapiens_hsa042101.03969054
46Amoebiasis_Homo sapiens_hsa051461.02333899
47Galactose metabolism_Homo sapiens_hsa000521.01585014
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00760755
49Vibrio cholerae infection_Homo sapiens_hsa051100.97230612
50Hepatitis C_Homo sapiens_hsa051600.87822619
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86706880
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86190856
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.85825437
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83284001
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82258953
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.81606372
57Herpes simplex infection_Homo sapiens_hsa051680.81186021
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.80199715
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.79555428
60Autoimmune thyroid disease_Homo sapiens_hsa053200.79005294
61Pentose phosphate pathway_Homo sapiens_hsa000300.78021506
62Ether lipid metabolism_Homo sapiens_hsa005650.74723968
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74470974
64Antigen processing and presentation_Homo sapiens_hsa046120.74244393
65Sphingolipid metabolism_Homo sapiens_hsa006000.73358724
66Fructose and mannose metabolism_Homo sapiens_hsa000510.71809367
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66766431
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66526149
69* Mineral absorption_Homo sapiens_hsa049780.65536686
70Hepatitis B_Homo sapiens_hsa051610.64898109
71Synaptic vesicle cycle_Homo sapiens_hsa047210.58265071
72Endocytosis_Homo sapiens_hsa041440.58166051
73Epstein-Barr virus infection_Homo sapiens_hsa051690.57737143
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57721509
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55617437
76Sulfur metabolism_Homo sapiens_hsa009200.55307465
77Fatty acid elongation_Homo sapiens_hsa000620.51615594
78Histidine metabolism_Homo sapiens_hsa003400.50825325
79Viral myocarditis_Homo sapiens_hsa054160.50813695
80Oxidative phosphorylation_Homo sapiens_hsa001900.48261661
81Renal cell carcinoma_Homo sapiens_hsa052110.47764241
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.46904313
83PPAR signaling pathway_Homo sapiens_hsa033200.46233773
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.44630107
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44025160
86Platelet activation_Homo sapiens_hsa046110.43732013
87Complement and coagulation cascades_Homo sapiens_hsa046100.40517161
88T cell receptor signaling pathway_Homo sapiens_hsa046600.37334167
89HIF-1 signaling pathway_Homo sapiens_hsa040660.35640754
90VEGF signaling pathway_Homo sapiens_hsa043700.35427147
91Pancreatic cancer_Homo sapiens_hsa052120.35182442
92Dorso-ventral axis formation_Homo sapiens_hsa043200.34438988
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33143384
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30363832
95Acute myeloid leukemia_Homo sapiens_hsa052210.29255637
96Type II diabetes mellitus_Homo sapiens_hsa049300.28691374
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28491700
98HTLV-I infection_Homo sapiens_hsa051660.28353839
99Prolactin signaling pathway_Homo sapiens_hsa049170.27040218
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25802434
101Alzheimers disease_Homo sapiens_hsa050100.25613262
102Notch signaling pathway_Homo sapiens_hsa043300.24195282
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.22517083
104Caffeine metabolism_Homo sapiens_hsa002320.22403618
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19632435
106Chronic myeloid leukemia_Homo sapiens_hsa052200.18222123
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18186766
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.17114089
109Proteoglycans in cancer_Homo sapiens_hsa052050.16962709
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16752011
111Insulin resistance_Homo sapiens_hsa049310.15545075
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.15203315
113Viral carcinogenesis_Homo sapiens_hsa052030.14815146
114Renin-angiotensin system_Homo sapiens_hsa046140.13973180
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13602387
116Glutathione metabolism_Homo sapiens_hsa004800.12106246
117Primary immunodeficiency_Homo sapiens_hsa053400.10327840

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