FST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)8.44466688
2negative regulation of keratinocyte proliferation (GO:0010839)6.41374213
3desmosome organization (GO:0002934)6.07065964
4G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071995.12724029
5lymph vessel development (GO:0001945)4.87275054
6negative regulation of cell fate specification (GO:0009996)4.78710140
7collagen fibril organization (GO:0030199)4.60238770
8chondrocyte proliferation (GO:0035988)4.55730835
9regulation of plasminogen activation (GO:0010755)4.53117567
10polarized epithelial cell differentiation (GO:0030859)4.41401077
11facial nerve structural organization (GO:0021612)4.36025582
12branching involved in salivary gland morphogenesis (GO:0060445)4.32805822
13endodermal cell differentiation (GO:0035987)4.30563265
14regulation of transforming growth factor beta2 production (GO:0032909)4.16457079
15regulation of keratinocyte proliferation (GO:0010837)4.16368526
16cell migration involved in sprouting angiogenesis (GO:0002042)4.11083534
17negative regulation of cell fate commitment (GO:0010454)4.10584069
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.06753623
19neural crest cell development (GO:0014032)4.04164359
20regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.90846687
21mesenchymal-epithelial cell signaling (GO:0060638)3.88570207
22viral transcription (GO:0019083)3.87826243
23sequestering of extracellular ligand from receptor (GO:0035581)3.83398343
24bone trabecula formation (GO:0060346)3.76196439
25cellular response to vitamin D (GO:0071305)3.74811412
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.74419582
27translational termination (GO:0006415)3.72446143
28regulation of cell fate specification (GO:0042659)3.70074898
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.69216932
30cell-substrate junction assembly (GO:0007044)3.68940107
31protein heterotrimerization (GO:0070208)3.68592219
32protein retention in ER lumen (GO:0006621)3.68157970
33wound healing, spreading of epidermal cells (GO:0035313)3.65844176
34paraxial mesoderm development (GO:0048339)3.60333922
35epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.59966415
36cartilage morphogenesis (GO:0060536)3.57508674
37outer ear morphogenesis (GO:0042473)3.57442581
38skin morphogenesis (GO:0043589)3.56390330
39basement membrane organization (GO:0071711)3.54713292
40ribosomal small subunit biogenesis (GO:0042274)3.53858417
41cell adhesion mediated by integrin (GO:0033627)3.52828147
42negative regulation of fibrinolysis (GO:0051918)3.52230405
43regulation of gastrulation (GO:0010470)3.50528612
44negative regulation of embryonic development (GO:0045992)3.48888669
45regulation of apoptotic process involved in morphogenesis (GO:1902337)3.46922559
46atrioventricular valve morphogenesis (GO:0003181)3.45812575
47* keratinocyte proliferation (GO:0043616)3.44446902
48regulation of phospholipase A2 activity (GO:0032429)3.39877047
49lateral sprouting from an epithelium (GO:0060601)3.37629568
50negative regulation of catenin import into nucleus (GO:0035414)3.36804451
51cellular response to vitamin (GO:0071295)3.36578659
52endocardial cushion development (GO:0003197)3.34589437
53epoxygenase P450 pathway (GO:0019373)3.33624509
54protein carboxylation (GO:0018214)3.32684689
55peptidyl-glutamic acid carboxylation (GO:0017187)3.32684689
56maturation of SSU-rRNA (GO:0030490)3.25315056
57regulation of heart morphogenesis (GO:2000826)3.24823961
58substrate adhesion-dependent cell spreading (GO:0034446)3.24009374
59extracellular matrix assembly (GO:0085029)3.22245766
60peptidyl-proline hydroxylation (GO:0019511)3.22189968
61lung-associated mesenchyme development (GO:0060484)3.20554222
62non-canonical Wnt signaling pathway (GO:0035567)3.20198646
63cardiac epithelial to mesenchymal transition (GO:0060317)3.18805478
64germ cell migration (GO:0008354)3.18742024
65negative regulation of chondrocyte differentiation (GO:0032331)3.18047133
66mesenchymal cell development (GO:0014031)3.17341442
67dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13275735
68regulation of tight junction assembly (GO:2000810)3.12701186
69establishment of apical/basal cell polarity (GO:0035089)3.11058769
70epithelial cell-cell adhesion (GO:0090136)3.10499019
71regulation of catenin import into nucleus (GO:0035412)3.10275924
72regulation of cardioblast differentiation (GO:0051890)3.09810867
73regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.09262170
74negative regulation of axon extension involved in axon guidance (GO:0048843)3.06859434
75wound healing, spreading of cells (GO:0044319)3.06319273
76epithelial to mesenchymal transition (GO:0001837)3.06261234
77positive regulation of cardiac muscle cell differentiation (GO:2000727)3.04942274
78Golgi transport vesicle coating (GO:0048200)3.03552473
79COPI coating of Golgi vesicle (GO:0048205)3.03552473
80endothelial cell morphogenesis (GO:0001886)3.01727477
81retina vasculature morphogenesis in camera-type eye (GO:0061299)3.00643585
82axon extension involved in axon guidance (GO:0048846)3.00599952
83neuron projection extension involved in neuron projection guidance (GO:1902284)3.00599952
84positive regulation of endothelial cell apoptotic process (GO:2000353)3.00567472
85translational elongation (GO:0006414)2.97812202
86SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97729923
87embryonic cranial skeleton morphogenesis (GO:0048701)2.96825681
88blood vessel endothelial cell migration (GO:0043534)2.96362133
89type B pancreatic cell proliferation (GO:0044342)2.96026899
90regulation of fibrinolysis (GO:0051917)2.95802316
91protein targeting to ER (GO:0045047)2.95133093
92protein localization to cell surface (GO:0034394)2.94937937
93substrate-dependent cell migration (GO:0006929)2.94723228
94cotranslational protein targeting to membrane (GO:0006613)2.92484930
95viral life cycle (GO:0019058)2.91663087
96cardiac right ventricle morphogenesis (GO:0003215)2.91229232
97negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.91118389
98phenol-containing compound catabolic process (GO:0019336)2.91058212
99notochord development (GO:0030903)2.89587532
100* odontogenesis (GO:0042476)2.89060456
101craniofacial suture morphogenesis (GO:0097094)2.88491119
102protein maturation by protein folding (GO:0022417)2.88475848
103hippo signaling (GO:0035329)2.88464891
104extracellular regulation of signal transduction (GO:1900115)2.86656358
105extracellular negative regulation of signal transduction (GO:1900116)2.86656358
106cellular protein complex disassembly (GO:0043624)2.86654417
107regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.85790172
108negative regulation of cartilage development (GO:0061037)2.84329814
109establishment of protein localization to endoplasmic reticulum (GO:0072599)2.83962425
110regulation of mesoderm development (GO:2000380)2.83625145
111cranial nerve structural organization (GO:0021604)2.81475249
112regulation of vitamin D biosynthetic process (GO:0060556)2.79245749
113gap junction assembly (GO:0016264)2.77104425
114regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.75211628
115proline biosynthetic process (GO:0006561)2.73682232
116somatic stem cell division (GO:0048103)2.73498040
117extracellular matrix disassembly (GO:0022617)2.73318349
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73024876
119positive regulation of collagen biosynthetic process (GO:0032967)2.72861434
120ephrin receptor signaling pathway (GO:0048013)2.71725269
121mesodermal cell differentiation (GO:0048333)2.71449525
122heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.67379024
123regulation of translational termination (GO:0006449)2.64766045
124regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63471598
125Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.62558718
126convergent extension (GO:0060026)2.58960774
127nucleotide-sugar biosynthetic process (GO:0009226)2.53826220
128ventricular cardiac muscle cell development (GO:0055015)2.52907637
129positive regulation of collagen metabolic process (GO:0010714)2.52147614
130adhesion of symbiont to host (GO:0044406)2.49971859
131collagen metabolic process (GO:0032963)2.48388016
132regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47394885
133anatomical structure arrangement (GO:0048532)2.45552015
134regulation of establishment of planar polarity (GO:0090175)2.45402190
135heparan sulfate proteoglycan metabolic process (GO:0030201)2.44213385
136regulation of protein activation cascade (GO:2000257)2.40089481
137hyaluronan catabolic process (GO:0030214)2.39294655
138cochlea morphogenesis (GO:0090103)2.38834456
139regulation of complement activation (GO:0030449)2.35838331
140endoderm development (GO:0007492)2.34388832
141establishment of tissue polarity (GO:0007164)2.33492389
142establishment of planar polarity (GO:0001736)2.33492389
143fibrinolysis (GO:0042730)2.31610429
144negative regulation of cardiac muscle tissue development (GO:0055026)2.29246299
145adherens junction assembly (GO:0034333)2.29192730
146negative regulation of BMP signaling pathway (GO:0030514)2.28569876
147protein localization to endosome (GO:0036010)2.28322440
148multicellular organismal macromolecule metabolic process (GO:0044259)2.28159603
149regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.27939409
150proline metabolic process (GO:0006560)2.27892427
151heterochromatin organization (GO:0070828)2.25905098
152embryonic foregut morphogenesis (GO:0048617)2.25423796
153extracellular matrix organization (GO:0030198)2.24430141
154collagen catabolic process (GO:0030574)2.24268688
155intestinal cholesterol absorption (GO:0030299)2.24246609
156extracellular structure organization (GO:0043062)2.23463308
157COPII vesicle coating (GO:0048208)2.22590642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.22176036
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.88263202
3E2F7_22180533_ChIP-Seq_HELA_Human3.61430318
4* SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.01463157
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.99518805
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.63589811
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.61126836
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54918031
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.54351111
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.33461699
11POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.32439029
12WT1_19549856_ChIP-ChIP_CCG9911_Human2.24369146
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.13700189
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.11944079
15CLOCK_20551151_ChIP-Seq_293T_Human2.11535136
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.02315364
17* CJUN_26792858_Chip-Seq_BT549_Human2.00172158
18TP63_17297297_ChIP-ChIP_HaCaT_Human11.2004385
19* TP53_20018659_ChIP-ChIP_R1E_Mouse1.99104554
20KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.96094553
21KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.96094553
22KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.96094553
23* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92719785
24* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92719785
25AR_21909140_ChIP-Seq_LNCAP_Human1.81790297
26* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.77516444
27* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.73178634
28* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72272302
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.71693703
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.66127892
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.64464700
32TCF3_18692474_ChIP-Seq_MEFs_Mouse1.61585963
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61483980
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.59646121
35* TP53_18474530_ChIP-ChIP_U2OS_Human1.57822183
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55755254
37E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50106666
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49994938
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.49083505
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48844755
41AR_21572438_ChIP-Seq_LNCaP_Human1.48657727
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48051062
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47927958
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47854682
45* TP53_16413492_ChIP-PET_HCT116_Human1.47043604
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46008383
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.44989001
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44137082
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42600149
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42600149
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42313311
52EGR1_19374776_ChIP-ChIP_THP-1_Human1.42167181
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41486931
54* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40958172
55* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38944979
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38809642
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.38700236
58SOX2_20726797_ChIP-Seq_SW620_Human1.38207504
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36823896
60ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36682182
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36394069
62SOX17_20123909_ChIP-Seq_XEN_Mouse1.35042512
63EOMES_21245162_ChIP-Seq_HESCs_Human1.34741950
64* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.33314190
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32402081
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31697185
67* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.31168463
68* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30608496
69ATF3_27146783_Chip-Seq_COLON_Human1.29555754
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29171703
71* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28948105
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.28207532
73CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27698658
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27297632
75* UBF1/2_26484160_Chip-Seq_HMECs_Human1.27033270
76* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26674123
77* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26674123
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.25000681
79* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24977995
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24684916
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22696132
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.21799122
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21716609
84* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21381528
85* EZH2_27304074_Chip-Seq_ESCs_Mouse1.19445663
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19199174
87RXR_22158963_ChIP-Seq_LIVER_Mouse1.18859812
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16181098
89* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15680532
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15006387
91SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.14820596
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14614833
93KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13812618
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13445684
95ELK3_25401928_ChIP-Seq_HUVEC_Human1.12395052
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10916658
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10483454
98SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10427530
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09876449
100UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09435416
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09069574
102MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08336444
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07694648
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07265439
105KLF5_25053715_ChIP-Seq_YYC3_Human1.06819851
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06722935
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05315276
108* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04401468
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03373216
110JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03341687
111ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03170014
112MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02760445
113CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.02206534
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.01914419
115ZNF263_19887448_ChIP-Seq_K562_Human1.01565958
116* TP53_22127205_ChIP-Seq_IMR90_Human1.00048111
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99962944
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99922878
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99687039
120* SA1_22415368_ChIP-Seq_MEFs_Mouse0.99060700
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98084460
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97355616
123ERG_21242973_ChIP-ChIP_JURKAT_Human0.97236120
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96969605
125* RACK7_27058665_Chip-Seq_MCF-7_Human0.96948849
126TP63_19390658_ChIP-ChIP_HaCaT_Human0.96913013
127* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96579697
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95467769
129MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95416208
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.95371786
131* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95138794
132* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95063433
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94626677
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93136050
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93031264
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.92373055
137* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91500648
138* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91480930
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91328111
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.90952206
141KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.90772410
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89598816
143* TP63_23658742_ChIP-Seq_EP156T_Human0.87504344
144TCF4_18268006_ChIP-ChIP_LS174T_Human0.85583868
145* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83530577
146TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82962700
147MYC_18555785_ChIP-Seq_MESCs_Mouse0.82723430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.97505838
2MP0008438_abnormal_cutaneous_collagen4.35044862
3MP0005275_abnormal_skin_tensile3.70658992
4MP0004272_abnormal_basement_membrane3.63925827
5MP0005623_abnormal_meninges_morphology3.42107754
6MP0003941_abnormal_skin_development3.22600598
7MP0000537_abnormal_urethra_morphology3.07757363
8MP0009384_cardiac_valve_regurgitation3.01923503
9MP0009053_abnormal_anal_canal2.99812835
10MP0002254_reproductive_system_inflammat2.80782326
11MP0010030_abnormal_orbit_morphology2.67695839
12MP0005503_abnormal_tendon_morphology2.49814408
13MP0005367_renal/urinary_system_phenotyp2.49290479
14MP0000516_abnormal_urinary_system2.49290479
15MP0002060_abnormal_skin_morphology2.35095035
16MP0003283_abnormal_digestive_organ2.34640082
17MP0009379_abnormal_foot_pigmentation2.30902149
18MP0003566_abnormal_cell_adhesion2.25083781
19MP0001346_abnormal_lacrimal_gland2.12918711
20MP0000762_abnormal_tongue_morphology2.07820961
21MP0009250_abnormal_appendicular_skeleto2.00664155
22MP0010352_gastrointestinal_tract_polyps1.95039752
23MP0002796_impaired_skin_barrier1.87973277
24MP0010368_abnormal_lymphatic_system1.78774381
25MP0003279_aneurysm1.77621860
26MP0000467_abnormal_esophagus_morphology1.73782995
27MP0000579_abnormal_nail_morphology1.71419769
28MP0005508_abnormal_skeleton_morphology1.69704059
29MP0002249_abnormal_larynx_morphology1.57915538
30MP0002282_abnormal_trachea_morphology1.56781606
31MP0000427_abnormal_hair_cycle1.51375839
32MP0003385_abnormal_body_wall1.51366502
33MP0008932_abnormal_embryonic_tissue1.50694228
34MP0005360_urolithiasis1.49335598
35MP0010234_abnormal_vibrissa_follicle1.48343300
36MP0003942_abnormal_urinary_system1.48208085
37MP0002234_abnormal_pharynx_morphology1.47049231
38MP0003453_abnormal_keratinocyte_physiol1.46617718
39MP0006054_spinal_hemorrhage1.43365966
40MP0000383_abnormal_hair_follicle1.42604200
41MP0005501_abnormal_skin_physiology1.40174707
42MP0003315_abnormal_perineum_morphology1.39904233
43MP0000377_abnormal_hair_follicle1.36623039
44MP0000049_abnormal_middle_ear1.35955449
45MP0003937_abnormal_limbs/digits/tail_de1.35653989
46MP0002089_abnormal_postnatal_growth/wei1.35255385
47MP0001299_abnormal_eye_distance/1.33711339
48MP0003890_abnormal_embryonic-extraembry1.32792034
49MP0005023_abnormal_wound_healing1.32288046
50* MP0003755_abnormal_palate_morphology1.31972924
51MP0003950_abnormal_plasma_membrane1.30325769
52MP0001340_abnormal_eyelid_morphology1.29687768
53MP0005187_abnormal_penis_morphology1.29439212
54MP0001958_emphysema1.28657527
55MP0003119_abnormal_digestive_system1.27978665
56MP0003091_abnormal_cell_migration1.26983547
57MP0000566_synostosis1.26108286
58* MP0001216_abnormal_epidermal_layer1.25939712
59MP0010771_integument_phenotype1.21911541
60MP0002697_abnormal_eye_size1.19256879
61MP0001243_abnormal_dermal_layer1.19213651
62MP0010678_abnormal_skin_adnexa1.18323800
63MP0002896_abnormal_bone_mineralization1.18268996
64MP0000428_abnormal_craniofacial_morphol1.17902608
65* MP0002098_abnormal_vibrissa_morphology1.16729291
66MP0005257_abnormal_intraocular_pressure1.14897026
67MP0000462_abnormal_digestive_system1.14405045
68MP0002177_abnormal_outer_ear1.14059192
69MP0000751_myopathy1.13152628
70MP0000538_abnormal_urinary_bladder1.12405530
71MP0002295_abnormal_pulmonary_circulatio1.10438195
72MP0001849_ear_inflammation1.10245231
73MP0000163_abnormal_cartilage_morphology1.08582829
74MP0002932_abnormal_joint_morphology1.06772561
75MP0002111_abnormal_tail_morphology1.05383992
76MP0000647_abnormal_sebaceous_gland1.05207577
77MP0000767_abnormal_smooth_muscle1.04476648
78MP0000534_abnormal_ureter_morphology1.02627090
79* MP0003935_abnormal_craniofacial_develop1.02114411
80MP0002102_abnormal_ear_morphology1.01923480
81MP0004858_abnormal_nervous_system1.01266364
82MP0000013_abnormal_adipose_tissue1.00061897
83* MP0002233_abnormal_nose_morphology0.99862961
84MP0001661_extended_life_span0.98484014
85* MP0000432_abnormal_head_morphology0.98022590
86MP0003122_maternal_imprinting0.96860811
87MP0008260_abnormal_autophagy0.94801421
88MP0003567_abnormal_fetal_cardiomyocyte0.94031365
89MP0002108_abnormal_muscle_morphology0.93685199
90MP0001348_abnormal_lacrimal_gland0.90185335
91MP0001730_embryonic_growth_arrest0.90128837
92MP0001879_abnormal_lymphatic_vessel0.90091267
93MP0002115_abnormal_skeleton_extremities0.89974965
94MP0003115_abnormal_respiratory_system0.88359533
95MP0009780_abnormal_chondrocyte_physiolo0.87361367
96MP0002085_abnormal_embryonic_tissue0.85110120
97MP0005408_hypopigmentation0.84765680
98MP0005171_absent_coat_pigmentation0.84333892
99MP0009840_abnormal_foam_cell0.82680175
100MP0002109_abnormal_limb_morphology0.82422402
101MP0002116_abnormal_craniofacial_bone0.82405351
102MP0002938_white_spotting0.82185997
103MP0001191_abnormal_skin_condition0.82101674
104MP0000750_abnormal_muscle_regeneration0.81700544
105MP0005076_abnormal_cell_differentiation0.81683116
106MP0001915_intracranial_hemorrhage0.81279544
107MP0001542_abnormal_bone_strength0.80925862
108MP0005193_abnormal_anterior_eye0.80154316
109MP0000003_abnormal_adipose_tissue0.79877116
110MP0000733_abnormal_muscle_development0.79320120
111MP0005390_skeleton_phenotype0.78749484
112MP0009697_abnormal_copulation0.76774861
113MP0005380_embryogenesis_phenotype0.75076356
114MP0001672_abnormal_embryogenesis/_devel0.75076356
115MP0003936_abnormal_reproductive_system0.75059470
116MP0001286_abnormal_eye_development0.74952710
117MP0000749_muscle_degeneration0.73641512
118MP0002084_abnormal_developmental_patter0.73490441
119MP0000678_abnormal_parathyroid_gland0.71404771
120* MP0002114_abnormal_axial_skeleton0.70189018
121MP0002086_abnormal_extraembryonic_tissu0.69919396
122MP0005197_abnormal_uvea_morphology0.68982085
123MP0004957_abnormal_blastocyst_morpholog0.68865281
124MP0003195_calcinosis0.68487053
125MP0003828_pulmonary_edema0.68467296
126* MP0009931_abnormal_skin_appearance0.67888938
127MP0004133_heterotaxia0.67793842
128MP0002092_abnormal_eye_morphology0.67560793
129MP0003111_abnormal_nucleus_morphology0.66716517
130MP0004134_abnormal_chest_morphology0.66201948
131* MP0002113_abnormal_skeleton_development0.65189743

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)6.03927930
2Protrusio acetabuli (HP:0003179)5.89172107
3Atrophic scars (HP:0001075)4.90084808
4Milia (HP:0001056)4.41122540
5Shallow orbits (HP:0000586)3.99789509
6Fragile nails (HP:0001808)3.69612159
7Fragile skin (HP:0001030)3.66972876
8Peritonitis (HP:0002586)3.45101510
9Aortic dissection (HP:0002647)3.06372607
10Plantar hyperkeratosis (HP:0007556)3.04227060
11Abnormality of carpal bone ossification (HP:0006257)3.02938262
12Soft skin (HP:0000977)3.01074801
13Ankle contracture (HP:0006466)3.00759080
14Down-sloping shoulders (HP:0200021)2.98395486
15Onycholysis (HP:0001806)2.96164504
16Wormian bones (HP:0002645)2.81495009
17Arterial tortuosity (HP:0005116)2.77209157
18Spinal rigidity (HP:0003306)2.71462910
19Abnormality of dentin (HP:0010299)2.61919080
20Type 1 muscle fiber predominance (HP:0003803)2.59178572
21Deep venous thrombosis (HP:0002625)2.54705587
22Increased connective tissue (HP:0009025)2.51846682
23Abnormal ossification of hand bones (HP:0005921)2.51514672
24Genu recurvatum (HP:0002816)2.49638171
25Cerebral aneurysm (HP:0004944)2.48278677
26Concave nail (HP:0001598)2.46312768
27Aplasia involving bones of the upper limbs (HP:0009823)2.45982526
28Aplasia of the phalanges of the hand (HP:0009802)2.45982526
29Aplasia involving bones of the extremities (HP:0009825)2.45982526
30Dilatation of the ascending aorta (HP:0005111)2.43509449
31Right ventricular cardiomyopathy (HP:0011663)2.43398167
32Abnormality of the acetabulum (HP:0003170)2.42460572
33Broad metatarsal (HP:0001783)2.42264994
34Hypotrichosis (HP:0001006)2.41084462
35Neonatal short-limb short stature (HP:0008921)2.38314985
36Pterygium (HP:0001059)2.38009289
37Double outlet right ventricle (HP:0001719)2.32554313
38Congenital malformation of the right heart (HP:0011723)2.32554313
39Selective tooth agenesis (HP:0001592)2.31055196
40Cardiovascular calcification (HP:0011915)2.29698220
41Aortic aneurysm (HP:0004942)2.28630988
42Knee flexion contracture (HP:0006380)2.27954939
43Elbow flexion contracture (HP:0002987)2.27194085
44Follicular hyperkeratosis (HP:0007502)2.26586613
45Thick nail (HP:0001805)2.25711653
46Thin bony cortex (HP:0002753)2.25087672
47Short middle phalanx of the 5th finger (HP:0004220)2.23783248
48Ridged nail (HP:0001807)2.22460135
49Renal duplication (HP:0000075)2.20444302
50Abnormal hand bone ossification (HP:0010660)2.20198954
51Bladder diverticulum (HP:0000015)2.20166103
52Back pain (HP:0003418)2.19256388
53Blue sclerae (HP:0000592)2.17866556
54Wide anterior fontanel (HP:0000260)2.17452910
55Wrist flexion contracture (HP:0001239)2.17393090
56Abnormal hemoglobin (HP:0011902)2.16924578
57Slender build (HP:0001533)2.16112345
58Fused cervical vertebrae (HP:0002949)2.15865930
59Round ear (HP:0100830)2.14491434
60Mitral valve prolapse (HP:0001634)2.14151047
61Abnormal delivery (HP:0001787)2.13846431
62Nail dystrophy (HP:0008404)2.06837286
63Short humerus (HP:0005792)2.06304213
64Abnormality of the parietal bone (HP:0002696)2.06228093
65Absent phalangeal crease (HP:0006109)2.06116083
66Morphological abnormality of the middle ear (HP:0008609)2.06051801
67Deviation of the thumb (HP:0009603)2.04943737
68Abnormality of the 2nd finger (HP:0004100)2.04010181
69Abnormality of the aortic arch (HP:0012303)2.02364327
70Lip pit (HP:0100267)2.01844336
71Abnormality of the fetal cardiovascular system (HP:0010948)2.01804454
72Abnormal umbilical cord blood vessels (HP:0011403)2.01804454
73Single umbilical artery (HP:0001195)2.01804454
74Vertebral compression fractures (HP:0002953)2.01118360
75Ulnar bowing (HP:0003031)1.99387950
76Esophageal atresia (HP:0002032)1.99069580
77Palmoplantar hyperkeratosis (HP:0000972)1.98335365
78Advanced eruption of teeth (HP:0006288)1.97788642
79Delayed cranial suture closure (HP:0000270)1.96365890
80Bronchomalacia (HP:0002780)1.96314920
81Buphthalmos (HP:0000557)1.95904212
82Tibial bowing (HP:0002982)1.95726086
83Aplasia/hypoplasia of the humerus (HP:0006507)1.95357817
84Aplasia cutis congenita (HP:0001057)1.94271656
85Short nail (HP:0001799)1.93318838
86Trismus (HP:0000211)1.92949593
87Vascular calcification (HP:0004934)1.91277766
88Flared iliac wings (HP:0002869)1.90891794
89Abnormality of the umbilical cord (HP:0010881)1.90726101
90Alopecia of scalp (HP:0002293)1.90669865
91Short hallux (HP:0010109)1.90136693
92Joint laxity (HP:0001388)1.89926390
93Overgrowth (HP:0001548)1.89750386
94Hyperextensible skin (HP:0000974)1.89251842
95Bowel diverticulosis (HP:0005222)1.89089172
96Coronal craniosynostosis (HP:0004440)1.88326193
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.88224875
98Ankyloglossia (HP:0010296)1.87603225
99Cervical subluxation (HP:0003308)1.87393812
100Proximal placement of thumb (HP:0009623)1.85997507
101Hypoplasia of the iris (HP:0007676)1.85658636
102Vascular tortuosity (HP:0004948)1.84895117
103Bell-shaped thorax (HP:0001591)1.84660241
104Palmar hyperkeratosis (HP:0010765)1.84178690
105Short 4th metacarpal (HP:0010044)1.83594398
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83594398
107Deviation of the hallux (HP:0010051)1.83476712
108Abnormality of the distal phalanges of the toes (HP:0010182)1.82950919
109Breech presentation (HP:0001623)1.81537560
110Coxa vara (HP:0002812)1.79847052
111Osteolytic defects of the hand bones (HP:0009699)1.79216393
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.79216393
113Small epiphyses (HP:0010585)1.78339155
114Abnormality of nail color (HP:0100643)1.78122948
115Natal tooth (HP:0000695)1.77645762
116Abnormality of the nasal septum (HP:0000419)1.77529838
117Hallux valgus (HP:0001822)1.77398439
118Cupped ribs (HP:0000887)1.76738427
119Abnormality of the proximal phalanges of the hand (HP:0009834)1.76649242
120Mildly elevated creatine phosphokinase (HP:0008180)1.75971290
121Protruding ear (HP:0000411)1.75352789
122Abnormality of the middle phalanges of the toes (HP:0010183)1.75008741
123Distal lower limb muscle weakness (HP:0009053)1.74897818
124Abnormalities of placenta or umbilical cord (HP:0001194)1.73991252
125Distal lower limb amyotrophy (HP:0008944)1.73852550
126Abnormality of oral frenula (HP:0000190)1.73731066
127Mesomelia (HP:0003027)1.73687336
128Hip contracture (HP:0003273)1.73686681
129Chin dimple (HP:0010751)1.73401431
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73354060
131Femoral bowing (HP:0002980)1.73254326
132Mitral regurgitation (HP:0001653)1.72564747
133Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71961958
134Disproportionate tall stature (HP:0001519)1.71576653
135Abnormality of the Achilles tendon (HP:0005109)1.71279814
136Tarsal synostosis (HP:0008368)1.70976083
137Camptodactyly of toe (HP:0001836)1.70822069
138Biconcave vertebral bodies (HP:0004586)1.70374053
139Abnormal vertebral ossification (HP:0100569)1.70190793
140Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.65066935
141Arnold-Chiari malformation (HP:0002308)1.61653764
142Generalized amyotrophy (HP:0003700)1.60358802
143Ovoid vertebral bodies (HP:0003300)1.60001778
144Breast hypoplasia (HP:0003187)1.59684161
145Achilles tendon contracture (HP:0001771)1.58767004
146Inguinal hernia (HP:0000023)1.58704159
147Abnormality of the alveolar ridges (HP:0006477)1.57973933
148Abnormal tarsal ossification (HP:0008369)1.57586697
149Midface retrusion (HP:0011800)1.56656425
150Mixed hearing impairment (HP:0000410)1.55337564
151Myelomeningocele (HP:0002475)1.54692810
152Thin skin (HP:0000963)1.54593161
153Arachnodactyly (HP:0001166)1.53537320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB27.13967604
2LATS24.77474344
3LATS13.96745170
4TTN2.80861315
5DDR22.80504847
6ERBB32.54567557
7EPHA22.51350730
8FER2.36646468
9MYLK2.19981429
10TRPM72.14812742
11BUB12.12037920
12ARAF1.95576311
13LRRK21.86831161
14TESK11.85219609
15PDGFRA1.83128936
16TGFBR21.80585698
17FLT31.75022321
18MAP3K31.73497033
19ERN11.71597592
20EPHA31.65623352
21MAPKAPK31.64356858
22TTK1.61745487
23FGFR21.59542543
24MST41.58964169
25PKN21.49001616
26FGFR11.48971783
27TGFBR11.47193912
28PTK21.44443624
29ERBB41.42652852
30LMTK21.38147303
31SRPK11.37349648
32LIMK11.36334974
33RPS6KA41.35006888
34BMPR1B1.33358981
35PIK3CG1.32202730
36TRIB31.31418054
37MAP3K91.29906171
38PAK21.27722495
39CDC71.26149202
40MST1R1.23314690
41EPHA41.23282935
42PAK31.19382801
43NUAK11.17531205
44STK38L1.08729561
45NEK11.06707491
46WEE11.05183228
47BRAF1.04027822
48PIM21.01910113
49MAP3K21.00101609
50MAP3K110.99724656
51NTRK10.99118092
52RIPK10.95619820
53TSSK60.94753955
54BCR0.93983916
55MOS0.91741698
56MAP2K10.91632528
57PTK60.91242663
58BRSK10.90346879
59CDK60.90190671
60ROCK20.89149830
61AKT30.85386546
62PLK40.84750317
63PBK0.84369419
64PLK10.84221835
65EIF2AK10.84137717
66STK30.81221250
67BMX0.81159666
68CDK80.80314255
69DMPK0.78564859
70SIK10.77818445
71ERBB20.76358007
72NEK20.74958520
73MKNK10.74401998
74NEK90.74158360
75MET0.73567948
76ROCK10.73147242
77STK160.72375561
78ICK0.71045336
79MAPKAPK50.69464871
80PAK40.68903769
81DYRK1B0.67639627
82WNK40.66362056
83MAP2K70.65780966
84WNK10.65242052
85PLK20.63428172
86STK100.60624342
87MTOR0.60068475
88RPS6KB20.58905087
89PRKD10.58350934
90ABL20.57934585
91PIK3CA0.57917547
92CDC42BPA0.56549066
93TAOK20.55941593
94AURKB0.54877888
95MAP3K80.54851848
96RET0.53216615
97STK380.52629440
98FGFR40.52423239
99MAP2K20.50975390
100MELK0.50447187
101CDK70.50193819
102PAK10.48075146
103SMG10.46584434
104CDK90.46228643
105AURKA0.45887295
106PDGFRB0.45690347
107ILK0.44439552
108CHEK20.42652187
109PRKG20.42278037
110PRKD20.42208088
111CDK180.41637920
112GRK70.41576452
113ADRBK10.41035422
114DAPK30.40565630
115PASK0.40373506
116PTK2B0.39734993
117NME20.38514424
118CSNK1A1L0.38268042
119CDK11A0.37943845
120PLK30.37794319
121YES10.37671028
122BRSK20.36759389
123CHEK10.36446074
124NME10.35937632
125MAPKAPK20.35706270
126INSR0.34841754
127TAOK10.33966122
128CDK120.33402697
129KSR20.33375888
130AKT20.32791508
131ZAK0.30378813
132EIF2AK20.30224717
133ABL10.29790388
134SRC0.29732330
135CDK140.29713075
136FRK0.29309353
137TYRO30.27714908
138CDK40.26695989
139CSNK1E0.25978698
140CHUK0.24598670
141CDK150.24593082
142IGF1R0.23677115
143GSK3A0.23423224

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.52193286
2Basal cell carcinoma_Homo sapiens_hsa052173.59188865
3Ribosome_Homo sapiens_hsa030103.28931289
4Hippo signaling pathway_Homo sapiens_hsa043902.98408728
5Hedgehog signaling pathway_Homo sapiens_hsa043402.90483719
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.67689349
7Bladder cancer_Homo sapiens_hsa052192.67557067
8Adherens junction_Homo sapiens_hsa045202.65148509
9Focal adhesion_Homo sapiens_hsa045102.63420546
10Small cell lung cancer_Homo sapiens_hsa052222.53158854
11Amoebiasis_Homo sapiens_hsa051462.50547769
12Proteoglycans in cancer_Homo sapiens_hsa052052.43825911
13* TGF-beta signaling pathway_Homo sapiens_hsa043502.41405183
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17457534
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.16274718
16Steroid biosynthesis_Homo sapiens_hsa001002.14020460
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09517232
18MicroRNAs in cancer_Homo sapiens_hsa052061.91407946
19Wnt signaling pathway_Homo sapiens_hsa043101.90295338
20p53 signaling pathway_Homo sapiens_hsa041151.78240393
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78215972
22Phenylalanine metabolism_Homo sapiens_hsa003601.72038948
23Axon guidance_Homo sapiens_hsa043601.68121588
24Melanogenesis_Homo sapiens_hsa049161.67597755
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.67479392
26DNA replication_Homo sapiens_hsa030301.67300154
27Melanoma_Homo sapiens_hsa052181.66819639
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.65665619
29N-Glycan biosynthesis_Homo sapiens_hsa005101.58977182
30Protein digestion and absorption_Homo sapiens_hsa049741.57993116
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57451423
32Biosynthesis of amino acids_Homo sapiens_hsa012301.55991695
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.52537018
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.49090763
35Tight junction_Homo sapiens_hsa045301.44252039
36Pathways in cancer_Homo sapiens_hsa052001.43668972
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42808458
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39182341
39Mismatch repair_Homo sapiens_hsa034301.35118904
40Galactose metabolism_Homo sapiens_hsa000521.34163856
41Vitamin B6 metabolism_Homo sapiens_hsa007501.33720652
42Thyroid cancer_Homo sapiens_hsa052161.31635884
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.30476650
44Sulfur relay system_Homo sapiens_hsa041221.29709069
45Dilated cardiomyopathy_Homo sapiens_hsa054141.29551424
46Tyrosine metabolism_Homo sapiens_hsa003501.28563174
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27056127
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.24322475
49Non-homologous end-joining_Homo sapiens_hsa034501.13378540
50Prostate cancer_Homo sapiens_hsa052151.11351441
51Arginine biosynthesis_Homo sapiens_hsa002201.10763244
52Toxoplasmosis_Homo sapiens_hsa051451.10466019
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08485025
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07375592
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07127722
56Rap1 signaling pathway_Homo sapiens_hsa040151.06363534
57Base excision repair_Homo sapiens_hsa034101.05309089
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.01796081
59Malaria_Homo sapiens_hsa051441.01350195
60Vitamin digestion and absorption_Homo sapiens_hsa049770.99697457
61Prion diseases_Homo sapiens_hsa050200.98510444
62HTLV-I infection_Homo sapiens_hsa051660.97157299
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96199108
64Protein export_Homo sapiens_hsa030600.94194576
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.93847347
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91938937
67Nucleotide excision repair_Homo sapiens_hsa034200.91763440
68Chemical carcinogenesis_Homo sapiens_hsa052040.90724418
69One carbon pool by folate_Homo sapiens_hsa006700.90533122
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.90080095
71Pyruvate metabolism_Homo sapiens_hsa006200.87300503
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86350089
73Shigellosis_Homo sapiens_hsa051310.86027824
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84828546
75Sulfur metabolism_Homo sapiens_hsa009200.83948626
76Fat digestion and absorption_Homo sapiens_hsa049750.81665741
77Chronic myeloid leukemia_Homo sapiens_hsa052200.80551778
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80064567
79Pyrimidine metabolism_Homo sapiens_hsa002400.78217330
80Viral myocarditis_Homo sapiens_hsa054160.75386112
81Endometrial cancer_Homo sapiens_hsa052130.75241562
82Glutathione metabolism_Homo sapiens_hsa004800.75234602
83Spliceosome_Homo sapiens_hsa030400.74406394
84Carbon metabolism_Homo sapiens_hsa012000.70028777
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67793172
86Glioma_Homo sapiens_hsa052140.66500223
87Other glycan degradation_Homo sapiens_hsa005110.66047558
88RNA polymerase_Homo sapiens_hsa030200.64640561
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64322807
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62468692
91Starch and sucrose metabolism_Homo sapiens_hsa005000.61996386
92Pancreatic cancer_Homo sapiens_hsa052120.61068507
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60896737
94Ovarian steroidogenesis_Homo sapiens_hsa049130.59064913
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58273156
96Complement and coagulation cascades_Homo sapiens_hsa046100.55267962
97Gap junction_Homo sapiens_hsa045400.55056176
98Ras signaling pathway_Homo sapiens_hsa040140.54845368
99mRNA surveillance pathway_Homo sapiens_hsa030150.54526569
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52391925
101Cocaine addiction_Homo sapiens_hsa050300.52317152
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52223535
103Estrogen signaling pathway_Homo sapiens_hsa049150.51241890
104Fatty acid elongation_Homo sapiens_hsa000620.51239239
105Salmonella infection_Homo sapiens_hsa051320.50847747
106Colorectal cancer_Homo sapiens_hsa052100.50418754
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49899451
108Platelet activation_Homo sapiens_hsa046110.49454737
109GnRH signaling pathway_Homo sapiens_hsa049120.49323668
110Glucagon signaling pathway_Homo sapiens_hsa049220.46802465
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46472057
112Apoptosis_Homo sapiens_hsa042100.46401000
113Pertussis_Homo sapiens_hsa051330.46082427
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44984282
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44778986
116TNF signaling pathway_Homo sapiens_hsa046680.44377221
117Fatty acid metabolism_Homo sapiens_hsa012120.43275600
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.43079865
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42687031
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41748697
121Fructose and mannose metabolism_Homo sapiens_hsa000510.40339161
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40044286
123Fanconi anemia pathway_Homo sapiens_hsa034600.40012727
124Homologous recombination_Homo sapiens_hsa034400.39056689
125Phagosome_Homo sapiens_hsa041450.38216339
126Viral carcinogenesis_Homo sapiens_hsa052030.37104838
127HIF-1 signaling pathway_Homo sapiens_hsa040660.36865583
128Retinol metabolism_Homo sapiens_hsa008300.36088880
129ErbB signaling pathway_Homo sapiens_hsa040120.35429902
130Histidine metabolism_Homo sapiens_hsa003400.34835954
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.33451403
132MAPK signaling pathway_Homo sapiens_hsa040100.28723801
133Cell cycle_Homo sapiens_hsa041100.28527781
134RNA transport_Homo sapiens_hsa030130.27463821
135Prolactin signaling pathway_Homo sapiens_hsa049170.26712303
136Hepatitis B_Homo sapiens_hsa051610.26197833
137Lysine degradation_Homo sapiens_hsa003100.23439983
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22034751
139VEGF signaling pathway_Homo sapiens_hsa043700.21449707
140Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21213433
141Renal cell carcinoma_Homo sapiens_hsa052110.20794458
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.20080908
143Proteasome_Homo sapiens_hsa030500.19931742
144Thyroid hormone synthesis_Homo sapiens_hsa049180.17448285
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.17255219
146Vibrio cholerae infection_Homo sapiens_hsa051100.17050996
147Oxytocin signaling pathway_Homo sapiens_hsa049210.16225401
148Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15973339
149Tryptophan metabolism_Homo sapiens_hsa003800.15040442
150Non-small cell lung cancer_Homo sapiens_hsa052230.14716713
151Arginine and proline metabolism_Homo sapiens_hsa003300.13530678

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