FSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.48588578
2neuron cell-cell adhesion (GO:0007158)5.40803900
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.27693063
4vocalization behavior (GO:0071625)5.17641805
5protein localization to synapse (GO:0035418)4.90635061
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88329101
7glutamate secretion (GO:0014047)4.85463513
8regulation of synaptic vesicle exocytosis (GO:2000300)4.61394857
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.59155572
10synaptic vesicle maturation (GO:0016188)4.47749470
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.46224119
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.32080713
13neurotransmitter-gated ion channel clustering (GO:0072578)4.28615597
14positive regulation of synapse maturation (GO:0090129)4.27904453
15regulation of glutamate receptor signaling pathway (GO:1900449)4.26840317
16neurotransmitter secretion (GO:0007269)4.07058813
17behavioral response to nicotine (GO:0035095)4.04768744
18cell migration in hindbrain (GO:0021535)4.04389226
19neuron recognition (GO:0008038)4.02532343
20regulation of synaptic vesicle transport (GO:1902803)4.01979023
21presynaptic membrane organization (GO:0097090)4.00249958
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.92900692
23neuronal action potential propagation (GO:0019227)3.87544846
24axonal fasciculation (GO:0007413)3.85517992
25layer formation in cerebral cortex (GO:0021819)3.80179146
26postsynaptic membrane organization (GO:0001941)3.79556512
27pyrimidine nucleobase catabolic process (GO:0006208)3.79375068
28negative regulation of microtubule polymerization (GO:0031115)3.77020765
29locomotory exploration behavior (GO:0035641)3.74666277
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.70447656
31regulation of neuronal synaptic plasticity (GO:0048168)3.68777548
32presynaptic membrane assembly (GO:0097105)3.67541250
33synaptic transmission, glutamatergic (GO:0035249)3.65901615
34neuron-neuron synaptic transmission (GO:0007270)3.65681378
35ionotropic glutamate receptor signaling pathway (GO:0035235)3.65515150
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.54147879
37proline transport (GO:0015824)3.53141893
38exploration behavior (GO:0035640)3.52260702
39glutamate receptor signaling pathway (GO:0007215)3.50404656
40positive regulation of synapse assembly (GO:0051965)3.48759849
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44027574
42cerebellar Purkinje cell differentiation (GO:0021702)3.42574489
43regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41392058
44synaptic vesicle endocytosis (GO:0048488)3.40937299
45regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.40415869
46regulation of synapse maturation (GO:0090128)3.38974469
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38126255
48regulation of synapse structural plasticity (GO:0051823)3.30915375
49response to pheromone (GO:0019236)3.28448776
50neurotransmitter transport (GO:0006836)3.28344136
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.27166740
52negative regulation of dendrite morphogenesis (GO:0050774)3.22568602
53behavioral fear response (GO:0001662)3.22550752
54behavioral defense response (GO:0002209)3.22550752
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.19026844
56negative regulation of dendrite development (GO:2000171)3.18191618
57regulation of excitatory postsynaptic membrane potential (GO:0060079)3.15653750
58dendritic spine morphogenesis (GO:0060997)3.15077532
59regulation of neurotransmitter secretion (GO:0046928)3.11440245
60regulation of postsynaptic membrane potential (GO:0060078)3.09815464
61auditory behavior (GO:0031223)3.09301531
62gamma-aminobutyric acid transport (GO:0015812)3.06487706
63cerebellar granule cell differentiation (GO:0021707)3.06122115
64regulation of synaptic plasticity (GO:0048167)3.04860314
65regulation of neurotransmitter levels (GO:0001505)3.04723629
66establishment of synaptic vesicle localization (GO:0097480)3.02895611
67synaptic vesicle transport (GO:0048489)3.02895611
68long-term synaptic potentiation (GO:0060291)3.02724720
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01493626
70transmission of nerve impulse (GO:0019226)3.01152564
71positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00102599
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00082751
73chaperone-mediated protein transport (GO:0072321)2.99952445
74positive regulation of membrane potential (GO:0045838)2.99475831
75fear response (GO:0042596)2.98382700
76mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.97333060
77establishment of mitochondrion localization (GO:0051654)2.97014412
78mechanosensory behavior (GO:0007638)2.96585307
79innervation (GO:0060384)2.95339048
80nucleobase catabolic process (GO:0046113)2.94404452
81neuronal ion channel clustering (GO:0045161)2.93496760
82regulation of neurotransmitter transport (GO:0051588)2.93448417
83response to histamine (GO:0034776)2.93412190
84neuromuscular process controlling posture (GO:0050884)2.93132722
85startle response (GO:0001964)2.92233411
86synapse assembly (GO:0007416)2.92139042
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91620981
88ATP hydrolysis coupled proton transport (GO:0015991)2.90471684
89energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.90471684
90establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.89441860
91mitochondrion transport along microtubule (GO:0047497)2.89441860
92regulation of synapse assembly (GO:0051963)2.89041903
93membrane hyperpolarization (GO:0060081)2.87007003
94adult walking behavior (GO:0007628)2.86463401
95regulation of vesicle fusion (GO:0031338)2.85633249
96dendrite development (GO:0016358)2.85290039
97positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85048757
98establishment of vesicle localization (GO:0051650)2.83086576
99long-term memory (GO:0007616)2.83060080
100membrane depolarization during action potential (GO:0086010)2.80736365
101transferrin transport (GO:0033572)2.80222649
102neuromuscular synaptic transmission (GO:0007274)2.79584789
103learning (GO:0007612)2.79455015
104positive regulation of dendritic spine morphogenesis (GO:0061003)2.66034778
105L-serine metabolic process (GO:0006563)2.53479248
106axon ensheathment in central nervous system (GO:0032291)2.46291759
107central nervous system myelination (GO:0022010)2.46291759
108response to auditory stimulus (GO:0010996)2.45419104
109central nervous system projection neuron axonogenesis (GO:0021952)2.45027651
110protein polyglutamylation (GO:0018095)2.42657718
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42117301
112protein deneddylation (GO:0000338)2.40261350
113histone arginine methylation (GO:0034969)2.39821075
114cullin deneddylation (GO:0010388)2.37898079
115retinal ganglion cell axon guidance (GO:0031290)2.37599321
116hippocampus development (GO:0021766)2.37454193
117spinal cord development (GO:0021510)2.34197940
118regulation of respiratory system process (GO:0044065)2.33835901
119anterograde axon cargo transport (GO:0008089)2.32672825
120axon cargo transport (GO:0008088)2.31830672
121dendritic spine organization (GO:0097061)2.31552026
122dendrite morphogenesis (GO:0048813)2.27700528
123regulation of cilium movement (GO:0003352)2.26668327
124regulation of microtubule-based movement (GO:0060632)2.26160157
125neurofilament cytoskeleton organization (GO:0060052)2.26114120
126synapse organization (GO:0050808)2.25209267
127positive regulation of dendritic spine development (GO:0060999)2.25166603
128membrane depolarization (GO:0051899)2.24983484
129regulation of dendritic spine morphogenesis (GO:0061001)2.23950010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.65138423
2GBX2_23144817_ChIP-Seq_PC3_Human3.76157555
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.14757198
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.93074498
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91386581
6REST_21632747_ChIP-Seq_MESCs_Mouse2.76951924
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75367126
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67856722
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.64795187
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48274254
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47501640
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47501640
13REST_18959480_ChIP-ChIP_MESCs_Mouse2.40195986
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35927240
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35720809
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33596207
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30493175
18TAF15_26573619_Chip-Seq_HEK293_Human2.30223916
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27258578
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.27048532
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21817216
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17850073
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12027920
24BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11969008
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.10991482
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10603785
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.10481974
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08871212
29EZH2_27294783_Chip-Seq_ESCs_Mouse2.08551442
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01238662
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92280943
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83528600
33RNF2_27304074_Chip-Seq_NSC_Mouse1.81301692
34IGF1R_20145208_ChIP-Seq_DFB_Human1.80379139
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78990264
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.77317432
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74124631
38DROSHA_22980978_ChIP-Seq_HELA_Human1.69607097
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69192358
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67971298
41AR_21572438_ChIP-Seq_LNCaP_Human1.64058001
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58804562
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57400412
44IRF1_19129219_ChIP-ChIP_H3396_Human1.53774212
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.52105504
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51422206
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50412716
48SMAD4_21799915_ChIP-Seq_A2780_Human1.50191145
49P300_19829295_ChIP-Seq_ESCs_Human1.45890101
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43801325
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.42840666
52ZNF274_21170338_ChIP-Seq_K562_Hela1.42671193
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42572887
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.39929353
55SOX2_16153702_ChIP-ChIP_HESCs_Human1.38191764
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.37995349
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36024347
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35758195
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32923205
60EST1_17652178_ChIP-ChIP_JURKAT_Human1.32690063
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32343910
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31954735
63FUS_26573619_Chip-Seq_HEK293_Human1.30965791
64HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30645536
65VDR_22108803_ChIP-Seq_LS180_Human1.30429386
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29399390
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28228105
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.23035959
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.22975747
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.22611202
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22532217
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20728059
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20179518
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19460520
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.19334076
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18810542
77ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17166185
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16448373
79MYC_18940864_ChIP-ChIP_HL60_Human1.15201375
80SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15197309
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14780137
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14378487
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14203037
84XRN2_22483619_ChIP-Seq_HELA_Human1.13389642
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13073195
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11632707
87AR_25329375_ChIP-Seq_VCAP_Human1.11357608
88STAT3_23295773_ChIP-Seq_U87_Human1.08632119
89P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08349879
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07611483
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07280854
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06393519
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.05629919
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04998871
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04569366
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.04328658
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.03398424
98JUN_21703547_ChIP-Seq_K562_Human1.02803301
99AR_19668381_ChIP-Seq_PC3_Human1.01580797
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01455588
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00648043
102TCF4_23295773_ChIP-Seq_U87_Human0.98314056
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97982036
104TTF2_22483619_ChIP-Seq_HELA_Human0.97753731
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97198334
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97198334
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96735746
108DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96474027
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95000193
110GABP_19822575_ChIP-Seq_HepG2_Human0.94915659
111YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94765061
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94271880
113SOX9_26525672_Chip-Seq_HEART_Mouse0.94221654
114CTCF_27219007_Chip-Seq_Bcells_Human0.94061997
115EWS_26573619_Chip-Seq_HEK293_Human0.93097741
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92889272
117RUNX2_22187159_ChIP-Seq_PCA_Human0.92209926
118OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92101652
119YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91867658
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91512597
121* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89623948
122PIAS1_25552417_ChIP-Seq_VCAP_Human0.89507587
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.89365385
124PRDM14_20953172_ChIP-Seq_ESCs_Human0.88609248
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88462436
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88295408
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87576243
128ER_23166858_ChIP-Seq_MCF-7_Human0.86777593
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86459828
130POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86008586
131POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.85301255
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.83727903
133TP53_20018659_ChIP-ChIP_R1E_Mouse0.83075438
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83075282
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81908430

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.97021048
2MP0003880_abnormal_central_pattern4.54451543
3MP0004270_analgesia3.52168364
4MP0003635_abnormal_synaptic_transmissio3.46535992
5MP0005423_abnormal_somatic_nervous3.14934763
6MP0001968_abnormal_touch/_nociception3.07037815
7MP0002063_abnormal_learning/memory/cond2.94518595
8MP0009745_abnormal_behavioral_response2.86052950
9MP0009046_muscle_twitch2.76023516
10MP0002734_abnormal_mechanical_nocicepti2.75496911
11MP0002064_seizures2.73548838
12MP0002736_abnormal_nociception_after2.64282339
13MP0002735_abnormal_chemical_nociception2.60853359
14MP0006276_abnormal_autonomic_nervous2.53137644
15MP0002572_abnormal_emotion/affect_behav2.52118891
16MP0002272_abnormal_nervous_system2.36921750
17MP0000778_abnormal_nervous_system2.33306179
18MP0001529_abnormal_vocalization2.24501827
19MP0003122_maternal_imprinting2.23304725
20MP0002733_abnormal_thermal_nociception2.20630567
21MP0001486_abnormal_startle_reflex2.20118255
22MP0002184_abnormal_innervation2.18673596
23MP0001970_abnormal_pain_threshold2.01209327
24MP0001440_abnormal_grooming_behavior1.95686548
25MP0003787_abnormal_imprinting1.93507731
26MP0002067_abnormal_sensory_capabilities1.92410361
27MP0005646_abnormal_pituitary_gland1.85156681
28MP0002653_abnormal_ependyma_morphology1.80731662
29MP0001984_abnormal_olfaction1.80404164
30MP0002822_catalepsy1.80038720
31MP0001501_abnormal_sleep_pattern1.77342918
32MP0002557_abnormal_social/conspecific_i1.74500343
33MP0004811_abnormal_neuron_physiology1.73292991
34MP0000955_abnormal_spinal_cord1.71646394
35MP0005386_behavior/neurological_phenoty1.61180464
36MP0004924_abnormal_behavior1.61180464
37MP0004858_abnormal_nervous_system1.59382577
38MP0001905_abnormal_dopamine_level1.55522438
39MP0008877_abnormal_DNA_methylation1.55156858
40MP0002882_abnormal_neuron_morphology1.53186561
41MP0004142_abnormal_muscle_tone1.51189504
42MP0005645_abnormal_hypothalamus_physiol1.49176895
43MP0003121_genomic_imprinting1.47584495
44MP0003329_amyloid_beta_deposits1.42134513
45MP0001188_hyperpigmentation1.36528805
46MP0003123_paternal_imprinting1.35399749
47MP0002066_abnormal_motor_capabilities/c1.35361735
48MP0000049_abnormal_middle_ear1.34509350
49MP0008569_lethality_at_weaning1.29031966
50MP0009780_abnormal_chondrocyte_physiolo1.24335412
51MP0002152_abnormal_brain_morphology1.24267972
52MP0001293_anophthalmia1.23804406
53MP0003879_abnormal_hair_cell1.23481084
54MP0002751_abnormal_autonomic_nervous1.20761521
55MP0001502_abnormal_circadian_rhythm1.19795798
56MP0003119_abnormal_digestive_system1.16890139
57MP0000631_abnormal_neuroendocrine_gland1.16605015
58MP0005394_taste/olfaction_phenotype1.16151169
59MP0005499_abnormal_olfactory_system1.16151169
60MP0003890_abnormal_embryonic-extraembry1.14175556
61MP0002752_abnormal_somatic_nervous1.10826486
62MP0003011_delayed_dark_adaptation1.08026384
63MP0010030_abnormal_orbit_morphology1.06049117
64MP0000751_myopathy1.05275456
65MP0004742_abnormal_vestibular_system1.03988218
66MP0003937_abnormal_limbs/digits/tail_de1.02579766
67MP0002102_abnormal_ear_morphology1.02511078
68MP0003136_yellow_coat_color1.00550161
69MP0002234_abnormal_pharynx_morphology0.97996107
70MP0003861_abnormal_nervous_system0.97615290
71MP0000566_synostosis0.96584955
72MP0001986_abnormal_taste_sensitivity0.95706943
73MP0003693_abnormal_embryo_hatching0.94869286
74MP0001963_abnormal_hearing_physiology0.93226394
75MP0003283_abnormal_digestive_organ0.92547073
76MP0002909_abnormal_adrenal_gland0.92266494
77MP0002229_neurodegeneration0.90253794
78MP0005253_abnormal_eye_physiology0.89245880
79MP0008058_abnormal_DNA_repair0.88041288
80MP0002069_abnormal_eating/drinking_beha0.87551721
81MP0003631_nervous_system_phenotype0.85671709
82MP0004885_abnormal_endolymph0.85528805
83MP0008789_abnormal_olfactory_epithelium0.84650083
84MP0001346_abnormal_lacrimal_gland0.83866532
85MP0002233_abnormal_nose_morphology0.82988349
86MP0005377_hearing/vestibular/ear_phenot0.81327058
87MP0003878_abnormal_ear_physiology0.81327058
88MP0001177_atelectasis0.80888035
89MP0003632_abnormal_nervous_system0.79511663
90MP0003646_muscle_fatigue0.79223643
91MP0002938_white_spotting0.78868883
92MP0005551_abnormal_eye_electrophysiolog0.77976812
93MP0004145_abnormal_muscle_electrophysio0.77347497
94MP0003567_abnormal_fetal_cardiomyocyte0.76966294
95MP0003633_abnormal_nervous_system0.76705299
96MP0000026_abnormal_inner_ear0.74108733
97MP0008872_abnormal_physiological_respon0.73542130
98MP0002081_perinatal_lethality0.73438927
99MP0001485_abnormal_pinna_reflex0.72765986
100MP0008932_abnormal_embryonic_tissue0.72256129
101MP0005195_abnormal_posterior_eye0.72030948
102MP0006292_abnormal_olfactory_placode0.71763067
103MP0003942_abnormal_urinary_system0.71613940
104MP0002638_abnormal_pupillary_reflex0.71260581
105MP0002876_abnormal_thyroid_physiology0.71254842
106MP0003634_abnormal_glial_cell0.71046513
107MP0000537_abnormal_urethra_morphology0.70714146
108MP0006072_abnormal_retinal_apoptosis0.70478062
109MP0004085_abnormal_heartbeat0.70447842
110MP0002837_dystrophic_cardiac_calcinosis0.70289368
111MP0002160_abnormal_reproductive_system0.69988694
112MP0008995_early_reproductive_senescence0.69292337
113MP0004233_abnormal_muscle_weight0.67804739
114MP0008260_abnormal_autophagy0.67480953
115MP0001299_abnormal_eye_distance/0.67398007
116MP0000534_abnormal_ureter_morphology0.67089007
117MP0003938_abnormal_ear_development0.65537601
118MP0001943_abnormal_respiration0.62501729
119MP0003137_abnormal_impulse_conducting0.61845840
120MP0005187_abnormal_penis_morphology0.61712794
121MP0003698_abnormal_male_reproductive0.61211319
122MP0010386_abnormal_urinary_bladder0.60324035
123MP0001664_abnormal_digestion0.59430507
124MP0010770_preweaning_lethality0.59178907
125MP0002082_postnatal_lethality0.59178907
126MP0004133_heterotaxia0.58234578
127MP0010769_abnormal_survival0.56757476

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20963668
2Myokymia (HP:0002411)6.05183031
3Focal seizures (HP:0007359)4.65214521
4Atonic seizures (HP:0010819)4.53272172
5Epileptic encephalopathy (HP:0200134)4.22511562
6Febrile seizures (HP:0002373)3.94359448
7Visual hallucinations (HP:0002367)3.73166008
8Progressive cerebellar ataxia (HP:0002073)3.72113866
9Absence seizures (HP:0002121)3.51865340
10Limb dystonia (HP:0002451)3.30216378
11Abnormal eating behavior (HP:0100738)3.24672035
12Polyphagia (HP:0002591)3.22451886
13Dialeptic seizures (HP:0011146)3.19373125
14Broad-based gait (HP:0002136)3.13338243
15Abnormality of the labia minora (HP:0012880)3.11863073
16Hyperventilation (HP:0002883)3.01674581
17Generalized tonic-clonic seizures (HP:0002069)3.01091060
18Pheochromocytoma (HP:0002666)3.00365829
19Failure to thrive in infancy (HP:0001531)2.97807112
20Ankle clonus (HP:0011448)2.94681964
21Retinal dysplasia (HP:0007973)2.91167034
22Abnormal hair whorl (HP:0010721)2.85037768
23Gait imbalance (HP:0002141)2.81014302
24Neuroendocrine neoplasm (HP:0100634)2.77967727
25Type II lissencephaly (HP:0007260)2.67522995
26Amblyopia (HP:0000646)2.65248744
27Impaired vibration sensation in the lower limbs (HP:0002166)2.63765450
28Abnormality of the corticospinal tract (HP:0002492)2.61545501
29Poor suck (HP:0002033)2.61257871
30Action tremor (HP:0002345)2.56382736
31Termporal pattern (HP:0011008)2.52050096
32Insidious onset (HP:0003587)2.52050096
33Abnormality of glycolysis (HP:0004366)2.51093761
34Increased serum pyruvate (HP:0003542)2.51093761
35Supranuclear gaze palsy (HP:0000605)2.46381090
36Specific learning disability (HP:0001328)2.46058078
37Excessive salivation (HP:0003781)2.41166023
38Drooling (HP:0002307)2.41166023
39Spastic gait (HP:0002064)2.40025432
40Urinary bladder sphincter dysfunction (HP:0002839)2.39510859
41Cortical dysplasia (HP:0002539)2.37771860
42Abnormality of the lower motor neuron (HP:0002366)2.36538644
43Congenital primary aphakia (HP:0007707)2.36032715
44Truncal ataxia (HP:0002078)2.34461376
45Gaze-evoked nystagmus (HP:0000640)2.33538887
46Mutism (HP:0002300)2.32700693
47Urinary urgency (HP:0000012)2.32161961
48Poor eye contact (HP:0000817)2.32054892
49Progressive inability to walk (HP:0002505)2.30374976
50Fetal akinesia sequence (HP:0001989)2.29152069
51Medial flaring of the eyebrow (HP:0010747)2.24897691
52Epileptiform EEG discharges (HP:0011182)2.22572567
53Nephronophthisis (HP:0000090)2.20755330
54Nephrogenic diabetes insipidus (HP:0009806)2.18883194
55Narrow nasal bridge (HP:0000446)2.18455763
56Cerebral hypomyelination (HP:0006808)2.18308399
57Hyperglycinemia (HP:0002154)2.17262603
58Pancreatic cysts (HP:0001737)2.17106079
59Septo-optic dysplasia (HP:0100842)2.16963227
60Dysdiadochokinesis (HP:0002075)2.16520015
61Pancreatic fibrosis (HP:0100732)2.15586414
62Colon cancer (HP:0003003)2.14782163
63Depression (HP:0000716)2.12830103
64Esotropia (HP:0000565)2.12417917
65EEG with generalized epileptiform discharges (HP:0011198)2.10245645
66Acute necrotizing encephalopathy (HP:0006965)2.09578404
67Torticollis (HP:0000473)2.08461029
68Delusions (HP:0000746)2.07596369
69Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07066485
70Hypoplasia of the brainstem (HP:0002365)2.07066485
71Pachygyria (HP:0001302)2.06493230
72Cerebellar dysplasia (HP:0007033)2.05612110
73Optic nerve hypoplasia (HP:0000609)2.05112553
74Genital tract atresia (HP:0001827)2.04710515
75Abnormal social behavior (HP:0012433)2.04475872
76Impaired social interactions (HP:0000735)2.04475872
77Anxiety (HP:0000739)2.03505259
78Hypoventilation (HP:0002791)2.02773635
79Sleep apnea (HP:0010535)2.02311049
80Dysmetria (HP:0001310)2.02139427
81Abnormality of midbrain morphology (HP:0002418)2.01693466
82Molar tooth sign on MRI (HP:0002419)2.01693466
83Hypsarrhythmia (HP:0002521)2.01657602
84Vaginal atresia (HP:0000148)2.00962024
85Abnormal mitochondria in muscle tissue (HP:0008316)1.98005671
86Protruding tongue (HP:0010808)1.97850715
87Hyperthyroidism (HP:0000836)1.97264826
88Inability to walk (HP:0002540)1.95176223
89Focal dystonia (HP:0004373)1.94914961
90Generalized hypotonia (HP:0001290)1.93397958
91Patellar aplasia (HP:0006443)1.92594849
92Absent speech (HP:0001344)1.91566669
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89925376
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.89925376
95Spastic tetraplegia (HP:0002510)1.89303124
96Akinesia (HP:0002304)1.89013067
97Morphological abnormality of the pyramidal tract (HP:0002062)1.88815164
98Oligodactyly (hands) (HP:0001180)1.88793741
99Neoplasm of the peripheral nervous system (HP:0100007)1.87873532
100Lower limb muscle weakness (HP:0007340)1.87489219
101Amyotrophic lateral sclerosis (HP:0007354)1.86352949
102Sclerocornea (HP:0000647)1.86138458
103Abnormality of pain sensation (HP:0010832)1.85722725
104Impaired pain sensation (HP:0007328)1.85722725
105Shoulder girdle muscle weakness (HP:0003547)1.85449487
106Scanning speech (HP:0002168)1.85318476
107Occipital encephalocele (HP:0002085)1.83663816
108Anencephaly (HP:0002323)1.82435421
109Anophthalmia (HP:0000528)1.82289646
110Oligomenorrhea (HP:0000876)1.82077665
111Progressive macrocephaly (HP:0004481)1.81511838
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80834826
113Hemiparesis (HP:0001269)1.80797182
114True hermaphroditism (HP:0010459)1.80552332
115Optic nerve coloboma (HP:0000588)1.80065713
116Aplasia/Hypoplasia of the patella (HP:0006498)1.79985290
117Craniofacial dystonia (HP:0012179)1.79346475
118Diplopia (HP:0000651)1.78110978
119Abnormality of binocular vision (HP:0011514)1.78110978
120Genetic anticipation (HP:0003743)1.76687160
121Agitation (HP:0000713)1.76523680
122Broad distal phalanx of finger (HP:0009836)1.74417609
123Poor coordination (HP:0002370)1.73939421
124Impaired smooth pursuit (HP:0007772)1.72717446
125Cutaneous finger syndactyly (HP:0010554)1.71775874
126Incomplete penetrance (HP:0003829)1.71153990
127Pendular nystagmus (HP:0012043)1.69794220
128Lissencephaly (HP:0001339)1.69585994
129Acute encephalopathy (HP:0006846)1.68714071
130Anosmia (HP:0000458)1.68593843
131Ulnar claw (HP:0001178)1.68584262
132Intestinal atresia (HP:0011100)1.68515129
133Preaxial hand polydactyly (HP:0001177)1.68052823
134Split foot (HP:0001839)1.67909419
135Status epilepticus (HP:0002133)1.65657562
136Oligodactyly (HP:0012165)1.64346413
137High anterior hairline (HP:0009890)1.64239985
138Absent septum pellucidum (HP:0001331)1.64039046
139Abnormal lung lobation (HP:0002101)1.63237120
140CNS hypomyelination (HP:0003429)1.62685806
141Abnormality of the renal medulla (HP:0100957)1.61751668
142Cutaneous syndactyly (HP:0012725)1.57223517
143Mitochondrial inheritance (HP:0001427)1.56216423
144Bilateral microphthalmos (HP:0007633)1.55465758
145Holoprosencephaly (HP:0001360)1.55252554
146Renal dysplasia (HP:0000110)1.54461300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.13487527
2MARK13.61697285
3NTRK33.56799579
4MAP3K93.27095022
5MAP3K43.05276203
6EPHA42.95726050
7MINK12.77648461
8MAP2K72.68888593
9MAP3K122.55470345
10TRIM282.23212005
11NTRK22.08045120
12MAPK132.05296135
13DAPK22.00605591
14PAK61.98280590
15PLK21.94466583
16BUB11.93893397
17KSR11.92413619
18PRPF4B1.90805425
19MAP4K21.86501594
20MAP2K41.75153970
21CDK191.71315705
22KSR21.62666296
23PINK11.62059961
24DAPK11.54796308
25BCKDK1.53035002
26SRPK11.50915388
27LATS21.50603431
28ZAK1.48607101
29CDC71.44570181
30ARAF1.42866043
31SIK31.41221826
32BCR1.40064599
33DYRK21.39855772
34UHMK11.35980964
35BRAF1.35926002
36AKT31.34724241
37GRK51.30970474
38CDK51.27910584
39PNCK1.26630142
40PHKG11.26189180
41PHKG21.26189180
42SGK2231.25285344
43SGK4941.25285344
44LIMK11.17926602
45TSSK61.15223723
46CDK181.14581847
47PRKCG1.13827990
48CCNB11.09669582
49CDK141.07319316
50NTRK11.06797274
51CDK151.04674502
52OXSR11.02108099
53PRKD31.00641807
54NME10.99576125
55DYRK30.99295055
56NEK20.96498031
57CAMK2A0.95072911
58PLK40.93146909
59FGFR20.92395854
60CDK11A0.91356336
61NEK10.90723592
62PLK10.87738566
63SGK20.86303564
64CSNK1G20.85984982
65PAK30.84078502
66TYRO30.81941764
67TNIK0.78477386
68CAMK2B0.78115739
69DYRK1A0.77444441
70ADRBK20.75339299
71TTK0.72996490
72MKNK20.71218085
73CSNK1G30.69997068
74TLK10.66366438
75ERBB40.64939339
76STK160.64088930
77CAMKK10.63423464
78EPHB20.62014699
79RPS6KA20.60520701
80MKNK10.59422409
81TAOK10.59344692
82MARK20.58561992
83LMTK20.58025234
84BMPR20.57629770
85WNK30.57594754
86CHEK20.57148526
87INSRR0.56746403
88VRK10.54453137
89PDK30.51306384
90PDK40.51306384
91ATR0.50998526
92CAMK40.50049685
93WNK40.49884218
94PLK30.49824427
95PRKCE0.49669770
96RAF10.49561521
97ADRBK10.48657326
98NUAK10.48556492
99ALK0.45461893
100ROCK20.45230528
101GRK10.44900513
102STK110.44727631
103DYRK1B0.44447818
104CSNK1D0.44083687
105MAP3K60.43914148
106MAP2K10.43871233
107FER0.42893519
108PRKCZ0.42715628
109STK380.42545901
110CAMK2G0.42244504
111SGK10.41501443
112CSNK1A10.40743003
113SGK30.40671669
114RET0.40500434
115AURKA0.40337075
116ERBB30.40032791
117CAMK1G0.39868584
118DAPK30.39704130
119VRK20.39415883
120RPS6KA50.39249444
121SIK20.38838099
122CSNK1A1L0.37432770
123TAF10.37016805
124CSNK1E0.35912610
125PKN10.35870857
126CSNK1G10.35747330
127CDK80.35054440
128MAPK100.34989349
129CAMKK20.33512748
130PTK2B0.33474532
131CAMK2D0.33286488
132RPS6KA30.32536395
133MUSK0.32106948
134FGR0.32106088
135CAMK10.30668538
136BRSK10.30142778

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.12998399
2Nicotine addiction_Homo sapiens_hsa050333.95551737
3Collecting duct acid secretion_Homo sapiens_hsa049662.66235232
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61935143
5GABAergic synapse_Homo sapiens_hsa047272.57489948
6Olfactory transduction_Homo sapiens_hsa047402.48902418
7Circadian entrainment_Homo sapiens_hsa047132.41792992
8Morphine addiction_Homo sapiens_hsa050322.31616548
9Long-term potentiation_Homo sapiens_hsa047202.27982335
10Glutamatergic synapse_Homo sapiens_hsa047242.26361360
11Dopaminergic synapse_Homo sapiens_hsa047282.20471159
12Amphetamine addiction_Homo sapiens_hsa050312.09908540
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92595732
14Oxidative phosphorylation_Homo sapiens_hsa001901.87007232
15Taste transduction_Homo sapiens_hsa047421.80627561
16Serotonergic synapse_Homo sapiens_hsa047261.79080757
17RNA polymerase_Homo sapiens_hsa030201.76389523
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76305692
19Vibrio cholerae infection_Homo sapiens_hsa051101.75767809
20Long-term depression_Homo sapiens_hsa047301.72444201
21Insulin secretion_Homo sapiens_hsa049111.68634845
22Cholinergic synapse_Homo sapiens_hsa047251.68297473
23Vitamin B6 metabolism_Homo sapiens_hsa007501.66147291
24Salivary secretion_Homo sapiens_hsa049701.64558588
25Axon guidance_Homo sapiens_hsa043601.59067449
26Cocaine addiction_Homo sapiens_hsa050301.51984697
27Parkinsons disease_Homo sapiens_hsa050121.48108322
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44291510
29Gap junction_Homo sapiens_hsa045401.40204278
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39817423
31Gastric acid secretion_Homo sapiens_hsa049711.39411601
32Oocyte meiosis_Homo sapiens_hsa041141.39190632
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36036585
34Cardiac muscle contraction_Homo sapiens_hsa042601.35832942
35Oxytocin signaling pathway_Homo sapiens_hsa049211.30439417
36Fanconi anemia pathway_Homo sapiens_hsa034601.27884990
37DNA replication_Homo sapiens_hsa030301.27475883
38Calcium signaling pathway_Homo sapiens_hsa040201.25380022
39Mismatch repair_Homo sapiens_hsa034301.24822147
40Steroid biosynthesis_Homo sapiens_hsa001001.24704724
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24691342
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23794666
43GnRH signaling pathway_Homo sapiens_hsa049121.23485884
44Ribosome_Homo sapiens_hsa030101.23296987
45Alzheimers disease_Homo sapiens_hsa050101.22360409
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22174070
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20629000
48Renin secretion_Homo sapiens_hsa049241.20064184
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18166405
50Huntingtons disease_Homo sapiens_hsa050161.17503879
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16932156
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16653364
53Spliceosome_Homo sapiens_hsa030401.14695285
54Basal transcription factors_Homo sapiens_hsa030221.14040718
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12991877
56Base excision repair_Homo sapiens_hsa034101.12047321
57ErbB signaling pathway_Homo sapiens_hsa040121.10912430
58Sulfur relay system_Homo sapiens_hsa041221.07997186
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05559859
60Melanogenesis_Homo sapiens_hsa049161.02675606
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01838755
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01002637
63Homologous recombination_Homo sapiens_hsa034400.98595786
64RNA degradation_Homo sapiens_hsa030180.93604847
65RNA transport_Homo sapiens_hsa030130.91494429
66Phototransduction_Homo sapiens_hsa047440.90279344
67Estrogen signaling pathway_Homo sapiens_hsa049150.88940156
68cAMP signaling pathway_Homo sapiens_hsa040240.87666292
69Glioma_Homo sapiens_hsa052140.86896914
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.84931503
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81565867
72Pyrimidine metabolism_Homo sapiens_hsa002400.81348305
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80222527
74Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79830301
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79376902
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75763720
77Purine metabolism_Homo sapiens_hsa002300.74991775
78Alcoholism_Homo sapiens_hsa050340.73932127
79Biosynthesis of amino acids_Homo sapiens_hsa012300.73702760
80Cell cycle_Homo sapiens_hsa041100.72267255
81Butanoate metabolism_Homo sapiens_hsa006500.71641406
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70852072
83Protein export_Homo sapiens_hsa030600.70244842
84Arginine and proline metabolism_Homo sapiens_hsa003300.69566893
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69109087
86Selenocompound metabolism_Homo sapiens_hsa004500.69099515
87Hedgehog signaling pathway_Homo sapiens_hsa043400.66632691
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64396283
89Endometrial cancer_Homo sapiens_hsa052130.62741074
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.62310532
91MAPK signaling pathway_Homo sapiens_hsa040100.61568850
92Type II diabetes mellitus_Homo sapiens_hsa049300.60148491
93Nucleotide excision repair_Homo sapiens_hsa034200.58984537
94Proteasome_Homo sapiens_hsa030500.58864613
95One carbon pool by folate_Homo sapiens_hsa006700.57018196
96Wnt signaling pathway_Homo sapiens_hsa043100.56608987
97Ras signaling pathway_Homo sapiens_hsa040140.56315771
98Colorectal cancer_Homo sapiens_hsa052100.55882426
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55741378
100Phagosome_Homo sapiens_hsa041450.54208029
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53564238
102Pyruvate metabolism_Homo sapiens_hsa006200.53350214
103Renal cell carcinoma_Homo sapiens_hsa052110.52135753
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51965071
105Non-homologous end-joining_Homo sapiens_hsa034500.50877942
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.50736687
107Dorso-ventral axis formation_Homo sapiens_hsa043200.50149708
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49943782
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49506289
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48645080
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48590539
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47215288
113Circadian rhythm_Homo sapiens_hsa047100.47073827
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45526585
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.45081922
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44926088
117Propanoate metabolism_Homo sapiens_hsa006400.44796845
118Ovarian steroidogenesis_Homo sapiens_hsa049130.44326056
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43870377
120Choline metabolism in cancer_Homo sapiens_hsa052310.43685891
121Rheumatoid arthritis_Homo sapiens_hsa053230.43429621
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42937576
123Melanoma_Homo sapiens_hsa052180.42504147
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42237626
125Metabolic pathways_Homo sapiens_hsa011000.41633880
126Dilated cardiomyopathy_Homo sapiens_hsa054140.41414026
127Hippo signaling pathway_Homo sapiens_hsa043900.41321919
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40989517
129Ether lipid metabolism_Homo sapiens_hsa005650.40381031
130Fatty acid elongation_Homo sapiens_hsa000620.40070441
131Rap1 signaling pathway_Homo sapiens_hsa040150.38739679
132Glucagon signaling pathway_Homo sapiens_hsa049220.38429978
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.36551740
134Regulation of autophagy_Homo sapiens_hsa041400.36044810
135Type I diabetes mellitus_Homo sapiens_hsa049400.35244699
136Basal cell carcinoma_Homo sapiens_hsa052170.35013195
137Thyroid hormone synthesis_Homo sapiens_hsa049180.33105562
138mRNA surveillance pathway_Homo sapiens_hsa030150.33066370
139Pancreatic secretion_Homo sapiens_hsa049720.33044121
140Endocytosis_Homo sapiens_hsa041440.32141362
141Prion diseases_Homo sapiens_hsa050200.31775039
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31704935
143VEGF signaling pathway_Homo sapiens_hsa043700.31555478

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