FSCN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.49266005
2plasma membrane fusion (GO:0045026)9.43579003
3motile cilium assembly (GO:0044458)9.40554295
4axonemal dynein complex assembly (GO:0070286)9.22561363
5reproduction (GO:0000003)9.06859297
6regulation of cilium movement (GO:0003352)8.75044815
7negative regulation of inclusion body assembly (GO:0090084)7.88710891
8cilium movement (GO:0003341)7.53006984
9organic cation transport (GO:0015695)7.30023072
10sperm capacitation (GO:0048240)7.25627810
11energy coupled proton transport, down electrochemical gradient (GO:0015985)7.23186688
12ATP synthesis coupled proton transport (GO:0015986)7.23186688
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.21593250
14cilium or flagellum-dependent cell motility (GO:0001539)7.12846656
15spermatogenesis (GO:0007283)7.12379170
16male gamete generation (GO:0048232)7.09677714
17single fertilization (GO:0007338)7.08796192
18synaptonemal complex organization (GO:0070193)6.86337560
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.80881586
20synaptonemal complex assembly (GO:0007130)6.78546252
21microtubule depolymerization (GO:0007019)6.76844470
22viral transcription (GO:0019083)6.60691073
23regulation of inclusion body assembly (GO:0090083)6.53900195
24gamete generation (GO:0007276)6.51880320
25chromosome condensation (GO:0030261)6.40688917
26translational termination (GO:0006415)6.38409927
27male meiosis (GO:0007140)6.34879737
28piRNA metabolic process (GO:0034587)6.11658689
29fertilization (GO:0009566)6.10897541
30DNA packaging (GO:0006323)6.05205964
31ribosomal small subunit biogenesis (GO:0042274)5.99789902
32calcium ion-dependent exocytosis (GO:0017156)5.86187385
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.59228785
34spermatid nucleus differentiation (GO:0007289)5.53713163
35germ cell development (GO:0007281)5.53098810
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.46544739
37cellular process involved in reproduction in multicellular organism (GO:0022412)5.41054748
38cotranslational protein targeting to membrane (GO:0006613)5.40605639
39protein targeting to ER (GO:0045047)5.37118755
40glycerol ether metabolic process (GO:0006662)5.35928456
41sexual reproduction (GO:0019953)5.28255400
42translational elongation (GO:0006414)5.22500484
43regulation of microtubule-based movement (GO:0060632)5.19628721
44respiratory electron transport chain (GO:0022904)5.17977149
45electron transport chain (GO:0022900)5.14095463
46establishment of protein localization to endoplasmic reticulum (GO:0072599)5.12823010
47multicellular organismal reproductive process (GO:0048609)5.12429732
48protein localization to endoplasmic reticulum (GO:0070972)5.06234514
49establishment of protein localization to mitochondrial membrane (GO:0090151)5.03325505
50cell recognition (GO:0008037)5.03287888
51maturation of SSU-rRNA (GO:0030490)5.02409969
52ribosomal small subunit assembly (GO:0000028)4.96697901
53ether metabolic process (GO:0018904)4.95060747
54cellular protein complex disassembly (GO:0043624)4.93537314
55single strand break repair (GO:0000012)4.91044363
56ventricular system development (GO:0021591)4.90700718
57microtubule severing (GO:0051013)4.84873670
58chaperone-mediated protein transport (GO:0072321)4.79185141
59protein complex biogenesis (GO:0070271)4.78490207
60seminiferous tubule development (GO:0072520)4.70998083
61viral life cycle (GO:0019058)4.62140583
62chromosome organization involved in meiosis (GO:0070192)4.54757406
63male meiosis I (GO:0007141)4.45926727
64mitochondrial respiratory chain complex assembly (GO:0033108)4.45653336
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.38098501
66ATP biosynthetic process (GO:0006754)4.38045364
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.37594492
68mitochondrial respiratory chain complex I assembly (GO:0032981)4.37594492
69NADH dehydrogenase complex assembly (GO:0010257)4.37594492
70left/right pattern formation (GO:0060972)4.31679997
71protein complex disassembly (GO:0043241)4.27933673
72chaperone-mediated protein complex assembly (GO:0051131)4.24593014
73sequestering of actin monomers (GO:0042989)4.16642477
74multicellular organismal development (GO:0007275)4.12951592
75purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.08003131
76macromolecular complex disassembly (GO:0032984)4.06097907
77purine nucleoside triphosphate biosynthetic process (GO:0009145)4.04450974
78translational initiation (GO:0006413)4.02856584
79DNA methylation involved in gamete generation (GO:0043046)3.93547806
80behavioral response to nicotine (GO:0035095)3.87333315
81meiotic nuclear division (GO:0007126)3.86820751
82rRNA modification (GO:0000154)3.82524954
83hydrogen ion transmembrane transport (GO:1902600)3.75908127
84response to pheromone (GO:0019236)3.73285733
85translation (GO:0006412)3.60172615
86regulation of spindle checkpoint (GO:0090231)3.58475774
87protein targeting to membrane (GO:0006612)3.57620172
88rRNA methylation (GO:0031167)3.55565725
89ribonucleoside triphosphate biosynthetic process (GO:0009201)3.53480797
90interferon-gamma secretion (GO:0072643)3.52366495
91meiosis I (GO:0007127)3.52057850
92protein polyglutamylation (GO:0018095)3.47220217
93protein refolding (GO:0042026)3.46794564
94proton transport (GO:0015992)3.46544204
95protein K11-linked deubiquitination (GO:0035871)3.46326010
96microtubule polymerization or depolymerization (GO:0031109)3.41947862
97hydrogen transport (GO:0006818)3.39895949
98protein neddylation (GO:0045116)3.39761424
99genitalia morphogenesis (GO:0035112)3.39045330
100RNA destabilization (GO:0050779)3.34886092
101polyamine biosynthetic process (GO:0006596)3.33884139
102cellular ketone body metabolic process (GO:0046950)3.33504370
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.32995541
104termination of RNA polymerase III transcription (GO:0006386)3.32995541
105positive regulation of macrophage activation (GO:0043032)3.31040254
106nucleus organization (GO:0006997)3.30432517
107RNA localization (GO:0006403)3.29818473
108ribosomal large subunit biogenesis (GO:0042273)3.24133124
109glycolytic process (GO:0006096)3.23356661
110protein-cofactor linkage (GO:0018065)3.20069552
111nucleoside triphosphate biosynthetic process (GO:0009142)3.20008969
112mitotic sister chromatid cohesion (GO:0007064)3.18188003
113chromatin silencing (GO:0006342)3.16226369
114carnitine transport (GO:0015879)3.15314442
115amino-acid betaine transport (GO:0015838)3.15314442
116meiotic cell cycle (GO:0051321)3.11913615
117nonmotile primary cilium assembly (GO:0035058)3.11500097
118nuclear-transcribed mRNA catabolic process (GO:0000956)3.10491915
119cellular component biogenesis (GO:0044085)3.04314139
120monoubiquitinated protein deubiquitination (GO:0035520)2.99630423
121carnitine transmembrane transport (GO:1902603)2.94279090
122ketone body metabolic process (GO:1902224)2.93403182
123nucleoside diphosphate phosphorylation (GO:0006165)2.91890849
124mRNA catabolic process (GO:0006402)2.90989751
125regulation of mitochondrial translation (GO:0070129)2.87473822
126cytochrome complex assembly (GO:0017004)2.86010117
127intracellular protein transmembrane import (GO:0044743)2.85895514
128polyol catabolic process (GO:0046174)2.85672634
129positive regulation of gastrulation (GO:2000543)2.83757038
130mitochondrion degradation (GO:0000422)2.83634031
131regulation of cilium assembly (GO:1902017)2.83226778
132nucleosome disassembly (GO:0006337)2.81447158
133protein-DNA complex disassembly (GO:0032986)2.81447158
134nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80544407
135protein localization to cilium (GO:0061512)2.79745162
136membrane protein intracellular domain proteolysis (GO:0031293)2.76413111
137pattern specification involved in kidney development (GO:0061004)2.76202114
138respiratory chain complex IV assembly (GO:0008535)2.73055001
139exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72392368
140peptidyl-histidine modification (GO:0018202)2.71088983
141alditol metabolic process (GO:0019400)2.70926917
142pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.70828373
143deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.69459391
144meiotic cell cycle process (GO:1903046)2.68523255
145ribonucleoprotein complex biogenesis (GO:0022613)2.64348054
146protein targeting (GO:0006605)2.60951848
147RNA catabolic process (GO:0006401)2.59448717
148cilium organization (GO:0044782)2.58661526
149GTP biosynthetic process (GO:0006183)2.58023257
150synapsis (GO:0007129)2.57963463
151establishment of protein localization to membrane (GO:0090150)2.57681630
152protein targeting to mitochondrion (GO:0006626)2.56850603
153platelet dense granule organization (GO:0060155)2.54091229
154establishment of protein localization to mitochondrion (GO:0072655)2.51273923
155purine nucleoside monophosphate biosynthetic process (GO:0009127)2.50765056
156purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.50765056
157cellular component assembly involved in morphogenesis (GO:0010927)2.49242100
158microtubule-based movement (GO:0007018)2.48731150
159cilium assembly (GO:0042384)2.48066664
160preassembly of GPI anchor in ER membrane (GO:0016254)2.47062635
161water-soluble vitamin biosynthetic process (GO:0042364)2.46818237
162oxidative phosphorylation (GO:0006119)2.46783498
163protein localization to mitochondrion (GO:0070585)2.45678915
164DNA deamination (GO:0045006)2.45384088
165negative regulation of gene expression, epigenetic (GO:0045814)2.45300985
166positive regulation of glycolytic process (GO:0045821)2.45152192
167UTP biosynthetic process (GO:0006228)2.43346520
168peptidyl-glutamic acid modification (GO:0018200)2.43223217
169cellular response to arsenic-containing substance (GO:0071243)2.40514068
170cilium morphogenesis (GO:0060271)2.40144031
171sperm motility (GO:0030317)14.6995973
172cell wall macromolecule catabolic process (GO:0016998)13.4637680
173cell wall macromolecule metabolic process (GO:0044036)13.4637680
174acrosome reaction (GO:0007340)13.0728773
175fusion of sperm to egg plasma membrane (GO:0007342)12.4096048
176sperm-egg recognition (GO:0035036)11.6132254
177acrosome assembly (GO:0001675)11.3873425
178binding of sperm to zona pellucida (GO:0007339)10.6884580
179cell-cell recognition (GO:0009988)10.4150780
180multicellular organism reproduction (GO:0032504)10.1503183
181spermatid development (GO:0007286)10.0799763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.86703194
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.67624215
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.24390006
4EZH2_22144423_ChIP-Seq_EOC_Human4.04751109
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.55798205
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.16331864
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04201334
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.00992271
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.92348082
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.88328749
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.84972324
12VDR_22108803_ChIP-Seq_LS180_Human2.69504971
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66050903
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59740241
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52474727
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45575562
17GATA1_26923725_Chip-Seq_HPCs_Mouse2.45287364
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.28993429
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28706999
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.26906430
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.25057985
22BMI1_23680149_ChIP-Seq_NPCS_Mouse2.17919157
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07721248
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06036011
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93824631
26ZNF274_21170338_ChIP-Seq_K562_Hela1.92872912
27FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90659274
28FUS_26573619_Chip-Seq_HEK293_Human1.82280494
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.80649715
30* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79802436
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.78300335
32ELK4_26923725_Chip-Seq_MESODERM_Mouse1.76629506
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.76029519
34STAT1_17558387_ChIP-Seq_HELA_Human1.70760337
35MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.70739328
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.69903882
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67196119
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.65871563
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.61776654
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61533241
41MYC_18940864_ChIP-ChIP_HL60_Human1.60940904
42FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.60300237
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.59693761
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59546323
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.54858344
46VDR_23849224_ChIP-Seq_CD4+_Human1.51049889
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.50543614
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49527606
49GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.49170873
50ERA_21632823_ChIP-Seq_H3396_Human1.49150365
51EZH2_27294783_Chip-Seq_ESCs_Mouse1.48667639
52PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.48502052
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.46767876
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44080196
55P53_21459846_ChIP-Seq_SAOS-2_Human1.40897793
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40813964
57JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40534316
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.40381007
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40275352
60KDM2B_26808549_Chip-Seq_REH_Human1.39866258
61TAF2_19829295_ChIP-Seq_ESCs_Human1.37923404
62CBP_20019798_ChIP-Seq_JUKART_Human1.37575443
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37575443
64TTF2_22483619_ChIP-Seq_HELA_Human1.37535844
65LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.37242544
66MYC_18555785_ChIP-Seq_MESCs_Mouse1.37133424
67TAL1_26923725_Chip-Seq_HPCs_Mouse1.36965787
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36328288
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35793461
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33335056
71CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32125742
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31645258
73SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31567504
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.31555248
75RNF2_27304074_Chip-Seq_NSC_Mouse1.30998007
76REST_21632747_ChIP-Seq_MESCs_Mouse1.30569887
77RAD21_21589869_ChIP-Seq_MESCs_Mouse1.29914262
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.29545785
79RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28319875
80GF1_26923725_Chip-Seq_HPCs_Mouse1.27979306
81XRN2_22483619_ChIP-Seq_HELA_Human1.27394042
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25056238
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.24035597
84MYC_19829295_ChIP-Seq_ESCs_Human1.23953618
85SPI1_26923725_Chip-Seq_HPCs_Mouse1.23554614
86CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23471612
87IRF1_19129219_ChIP-ChIP_H3396_Human1.23249967
88THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20993301
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20422634
90RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19837246
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19715893
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.19667240
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19667240
94TP53_22573176_ChIP-Seq_HFKS_Human1.18483262
95GATA1_19941827_ChIP-Seq_MEL86_Mouse1.17835974
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17440820
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17440820
98P300_19829295_ChIP-Seq_ESCs_Human1.16184076
99JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15433757
100MYC_27129775_Chip-Seq_CORNEA_Mouse1.15364475
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.14814140
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.14153905
103NCOR_22424771_ChIP-Seq_293T_Human1.13805213
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12515830
105ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12058926
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12050360
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11797296
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11575396
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11075708
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10980119
111ERG_20517297_ChIP-Seq_VCAP_Human1.10771149
112RARA_24833708_ChIP-Seq_LIVER_Mouse1.10259984
113YY1_22570637_ChIP-Seq_MALME-3M_Human1.10110988
114RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10101240
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09335868
116CTCF_20526341_ChIP-Seq_ESCs_Human1.08797509
117EWS_26573619_Chip-Seq_HEK293_Human1.08602098
118REST_18959480_ChIP-ChIP_MESCs_Mouse1.08544541
119TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08501839
120SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08339348
121NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08001820
122ESET_19884257_ChIP-Seq_ESCs_Mouse1.07592813
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07251321
124BCOR_27268052_Chip-Seq_Bcells_Human1.07073195
125ELF1_20517297_ChIP-Seq_JURKAT_Human1.06924101
126SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06848505
127EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06341916
128TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06285284
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.05981019
130ELK1_19687146_ChIP-ChIP_HELA_Human1.05440964
131NFE2_27457419_Chip-Seq_LIVER_Mouse1.05103054
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.04822062
133AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04372356
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03959926
135NANOG_19829295_ChIP-Seq_ESCs_Human1.03917913
136SOX2_19829295_ChIP-Seq_ESCs_Human1.03917913
137* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03719195
138TP53_20018659_ChIP-ChIP_R1E_Mouse1.03698769
139PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03476618
140FOXP3_21729870_ChIP-Seq_TREG_Human1.03138684
141CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03049977
142LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02973346
143SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02232625
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99908579
145UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99710870
146FOXP1_21924763_ChIP-Seq_HESCs_Human0.98118625
147SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.97740314
148RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.97601179
149KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.97378414
150* CTCF_27219007_Chip-Seq_Bcells_Human0.97201854
151AR_25329375_ChIP-Seq_VCAP_Human0.97157389
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.97151332
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97065689
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.97036012
155E2F1_20622854_ChIP-Seq_HELA_Human0.96946182
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96511839
157SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96347753
158TAF15_26573619_Chip-Seq_HEK293_Human0.96292785
159ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95595353
160AR_20517297_ChIP-Seq_VCAP_Human0.95125085
161POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94881887
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94775545
163NANOG_20526341_ChIP-Seq_ESCs_Human0.94172196
164CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94087831
165BCL6_27268052_Chip-Seq_Bcells_Human0.93968578
166CRX_20693478_ChIP-Seq_RETINA_Mouse0.92877936
167PCGF2_27294783_Chip-Seq_NPCs_Mouse0.91380705
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.90699736
169CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90187887
170PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89958357
171PHF8_20622854_ChIP-Seq_HELA_Human0.89540761
172ETV2_25802403_ChIP-Seq_MESCs_Mouse0.89118546
173MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88908444
174LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88155388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02019740
2MP0001929_abnormal_gametogenesis5.49781409
3MP0009379_abnormal_foot_pigmentation4.46245718
4MP0008877_abnormal_DNA_methylation3.50736627
5MP0002161_abnormal_fertility/fecundity3.28630712
6MP0005670_abnormal_white_adipose3.24454976
7MP0002210_abnormal_sex_determination3.18766819
8MP0001145_abnormal_male_reproductive2.72005944
9MP0006292_abnormal_olfactory_placode2.52563911
10MP0000653_abnormal_sex_gland2.33247064
11MP0006072_abnormal_retinal_apoptosis2.04504979
12MP0005410_abnormal_fertilization17.0129963
13MP0005423_abnormal_somatic_nervous1.97271228
14MP0001905_abnormal_dopamine_level1.87032967
15MP0000049_abnormal_middle_ear1.82890176
16MP0006276_abnormal_autonomic_nervous1.82624173
17MP0002735_abnormal_chemical_nociception1.78979835
18MP0002837_dystrophic_cardiac_calcinosis1.77764570
19MP0002272_abnormal_nervous_system1.77427699
20MP0002638_abnormal_pupillary_reflex1.74180246
21MP0009745_abnormal_behavioral_response1.70838888
22MP0002653_abnormal_ependyma_morphology1.69960961
23MP0004142_abnormal_muscle_tone1.69133537
24MP0010030_abnormal_orbit_morphology1.64765498
25MP0003136_yellow_coat_color1.63866559
26MP0005646_abnormal_pituitary_gland1.60951217
27MP0000631_abnormal_neuroendocrine_gland1.58717804
28MP0005084_abnormal_gallbladder_morpholo1.58491958
29MP0002938_white_spotting1.58289631
30MP0003646_muscle_fatigue1.56155541
31MP0003880_abnormal_central_pattern1.50527923
32MP0004885_abnormal_endolymph1.50521167
33MP0002160_abnormal_reproductive_system1.49922002
34MP0002163_abnormal_gland_morphology1.48767533
35MP0002733_abnormal_thermal_nociception1.47649951
36MP0001485_abnormal_pinna_reflex1.46326859
37MP0002277_abnormal_respiratory_mucosa1.46149692
38MP0002822_catalepsy1.45735819
39MP0002876_abnormal_thyroid_physiology1.42613202
40MP0004233_abnormal_muscle_weight1.42366197
41MP0001970_abnormal_pain_threshold1.38194104
42MP0004147_increased_porphyrin_level1.35384501
43MP0000566_synostosis1.33393320
44MP0002557_abnormal_social/conspecific_i1.31100084
45MP0003938_abnormal_ear_development1.30213126
46MP0008789_abnormal_olfactory_epithelium1.29154821
47MP0005645_abnormal_hypothalamus_physiol1.28123615
48MP0003718_maternal_effect1.27265979
49MP0001529_abnormal_vocalization1.27094070
50MP0002572_abnormal_emotion/affect_behav1.25587958
51MP0002064_seizures1.24926809
52MP0001486_abnormal_startle_reflex1.22818275
53MP0005379_endocrine/exocrine_gland_phen1.21737214
54MP0001986_abnormal_taste_sensitivity1.19480517
55MP0003635_abnormal_synaptic_transmissio1.16841941
56MP0005623_abnormal_meninges_morphology1.15369863
57MP0008872_abnormal_physiological_respon1.14944081
58MP0000026_abnormal_inner_ear1.13972391
59MP0001501_abnormal_sleep_pattern1.10077375
60MP0001919_abnormal_reproductive_system1.09875756
61MP0001765_abnormal_ion_homeostasis1.08921657
62MP0003283_abnormal_digestive_organ1.07250087
63MP0000372_irregular_coat_pigmentation1.07020763
64MP0005394_taste/olfaction_phenotype1.06576927
65MP0005499_abnormal_olfactory_system1.06576927
66MP0001963_abnormal_hearing_physiology1.02776785
67MP0003121_genomic_imprinting1.02615668
68MP0010386_abnormal_urinary_bladder1.02574684
69MP0005195_abnormal_posterior_eye1.00140533
70MP0003122_maternal_imprinting0.98710997
71MP0001984_abnormal_olfaction0.98312958
72MP0005174_abnormal_tail_pigmentation0.98187439
73MP0002734_abnormal_mechanical_nocicepti0.95693653
74MP0002095_abnormal_skin_pigmentation0.95409404
75MP0002234_abnormal_pharynx_morphology0.94812066
76MP0002282_abnormal_trachea_morphology0.94703929
77MP0000955_abnormal_spinal_cord0.94161769
78MP0001188_hyperpigmentation0.94035250
79MP0002067_abnormal_sensory_capabilities0.93472542
80MP0003186_abnormal_redox_activity0.93174501
81MP0003195_calcinosis0.92642086
82MP0002063_abnormal_learning/memory/cond0.91966634
83MP0005332_abnormal_amino_acid0.91512288
84MP0002752_abnormal_somatic_nervous0.87228195
85MP0004859_abnormal_synaptic_plasticity0.86324333
86MP0002249_abnormal_larynx_morphology0.82372788
87MP0002184_abnormal_innervation0.81691512
88MP0005647_abnormal_sex_gland0.81511183
89MP0003119_abnormal_digestive_system0.80112773
90MP0002229_neurodegeneration0.78320664
91MP0008058_abnormal_DNA_repair0.76128855
92MP0000569_abnormal_digit_pigmentation0.74041687
93MP0003115_abnormal_respiratory_system0.73336009
94MP0005389_reproductive_system_phenotype0.72214327
95MP0005636_abnormal_mineral_homeostasis0.64276056
96MP0005666_abnormal_adipose_tissue0.59511550
97MP0003878_abnormal_ear_physiology0.59131617
98MP0005377_hearing/vestibular/ear_phenot0.59131617
99MP0003329_amyloid_beta_deposits0.54703620
100MP0001324_abnormal_eye_pigmentation0.53804926
101MP0008995_early_reproductive_senescence0.53780588
102MP0009046_muscle_twitch0.53343313
103MP0003011_delayed_dark_adaptation0.52814176
104MP0001764_abnormal_homeostasis0.51180531
105MP0005397_hematopoietic_system_phenotyp0.50447358
106MP0001545_abnormal_hematopoietic_system0.50447358
107MP0004036_abnormal_muscle_relaxation0.47767335
108MP0002269_muscular_atrophy0.47662591
109MP0001293_anophthalmia0.45912290
110MP0003699_abnormal_female_reproductive0.44731953
111MP0000534_abnormal_ureter_morphology0.44217870
112MP0006036_abnormal_mitochondrial_physio0.43936099
113MP0009115_abnormal_fat_cell0.43703361
114MP0002736_abnormal_nociception_after0.43345062
115MP0000358_abnormal_cell_content/0.40717875
116MP0009278_abnormal_bone_marrow0.39111621
117MP0002928_abnormal_bile_duct0.36885415
118MP0000604_amyloidosis0.34730059
119MP0002139_abnormal_hepatobiliary_system0.32829082
120MP0003942_abnormal_urinary_system0.32438868
121MP0004811_abnormal_neuron_physiology0.30946345
122MP0001849_ear_inflammation0.29476530
123MP0005253_abnormal_eye_physiology0.29140487
124MP0010094_abnormal_chromosome_stability0.29059038
125MP0004133_heterotaxia0.28825297
126MP0002971_abnormal_brown_adipose0.27828513
127MP0003111_abnormal_nucleus_morphology0.27553065
128MP0002405_respiratory_system_inflammati0.27510790
129MP0002295_abnormal_pulmonary_circulatio0.26911204
130MP0003959_abnormal_lean_body0.26197773
131MP0005551_abnormal_eye_electrophysiolog0.26150612
132MP0001730_embryonic_growth_arrest0.25873402
133MP0006035_abnormal_mitochondrial_morpho0.25868905
134MP0005391_vision/eye_phenotype0.25373434
135MP0003948_abnormal_gas_homeostasis0.25191080
136MP0003879_abnormal_hair_cell0.24484410
137MP0002169_no_abnormal_phenotype0.24127012
138MP0002873_normal_phenotype0.23924775
139MP0003633_abnormal_nervous_system0.22765417
140MP0001348_abnormal_lacrimal_gland0.22631202
141MP0001119_abnormal_female_reproductive0.22307719
142MP0003950_abnormal_plasma_membrane0.21953744
143MP0004742_abnormal_vestibular_system0.21415882
144MP0003631_nervous_system_phenotype0.20169907
145MP0001968_abnormal_touch/_nociception0.19917900
146MP0003787_abnormal_imprinting0.18516953
147MP0003861_abnormal_nervous_system0.18319119
148MP0002693_abnormal_pancreas_physiology0.17800129
149MP0002152_abnormal_brain_morphology0.16837406
150MP0002092_abnormal_eye_morphology0.15874427
151MP0008569_lethality_at_weaning0.15868510
152MP0005319_abnormal_enzyme/_coenzyme0.15584535
153MP0005375_adipose_tissue_phenotype0.15451581
154MP0008875_abnormal_xenobiotic_pharmacok0.14238399
155MP0000001_mammalian_phenotype0.14191267
156MP0010307_abnormal_tumor_latency0.13868820
157MP0000313_abnormal_cell_death0.13556309
158MP0002118_abnormal_lipid_homeostasis0.12505600
159MP0004019_abnormal_vitamin_homeostasis0.12114879
160MP0000751_myopathy0.12089273
161MP0005584_abnormal_enzyme/coenzyme_acti0.11133040
162MP0003936_abnormal_reproductive_system0.10700499
163MP0002909_abnormal_adrenal_gland0.10655209
164MP0000015_abnormal_ear_pigmentation0.10598427
165MP0000249_abnormal_blood_vessel0.10504946
166MP0008770_decreased_survivor_rate0.10068677
167MP0004808_abnormal_hematopoietic_stem0.09908644
168MP0010329_abnormal_lipoprotein_level0.09233402
169MP0005535_abnormal_body_temperature0.09006118
170MP0005380_embryogenesis_phenotype0.08917487
171MP0001672_abnormal_embryogenesis/_devel0.08917487

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.28249283
2Abnormal respiratory motile cilium morphology (HP:0005938)9.28249283
3Abnormal respiratory motile cilium physiology (HP:0012261)9.16001147
4Rhinitis (HP:0012384)7.35662343
5Infertility (HP:0000789)7.33003183
6Chronic bronchitis (HP:0004469)7.27469662
7Abnormal ciliary motility (HP:0012262)7.03731233
8Nasal polyposis (HP:0100582)6.51110800
9Abnormality of the nasal mucosa (HP:0000433)5.35616566
10Male infertility (HP:0003251)5.23591937
11Acute necrotizing encephalopathy (HP:0006965)4.73592751
12Bronchitis (HP:0012387)4.62591231
13Renal Fanconi syndrome (HP:0001994)4.61430688
14Mitochondrial inheritance (HP:0001427)4.46096221
15Increased hepatocellular lipid droplets (HP:0006565)4.40638566
16Abnormal mitochondria in muscle tissue (HP:0008316)4.36493812
17Bronchiectasis (HP:0002110)4.32689553
18Lipid accumulation in hepatocytes (HP:0006561)4.24105789
19Nephronophthisis (HP:0000090)3.96836846
20Acute encephalopathy (HP:0006846)3.95644107
21Progressive macrocephaly (HP:0004481)3.92937247
22Increased CSF lactate (HP:0002490)3.88805386
23Abnormal spermatogenesis (HP:0008669)3.84371720
24Reticulocytopenia (HP:0001896)3.74616240
253-Methylglutaconic aciduria (HP:0003535)3.71496460
26Macrocytic anemia (HP:0001972)3.55888436
27Increased intramyocellular lipid droplets (HP:0012240)3.41208661
28Hepatocellular necrosis (HP:0001404)3.37764260
29Abnormal number of erythroid precursors (HP:0012131)3.35330889
30Abnormality of cells of the erythroid lineage (HP:0012130)3.35011721
31Recurrent otitis media (HP:0000403)3.34941530
32Pancreatic cysts (HP:0001737)3.34059366
33Exertional dyspnea (HP:0002875)3.30368513
34Hepatic necrosis (HP:0002605)3.25565333
35Recurrent sinusitis (HP:0011108)3.22575369
36Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05662639
37Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05607690
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05607690
39Glycosuria (HP:0003076)3.02997999
40Abnormality of urine glucose concentration (HP:0011016)3.02997999
41Pancreatic fibrosis (HP:0100732)2.98495623
42Increased muscle lipid content (HP:0009058)2.96938388
43Abnormality of the renal medulla (HP:0100957)2.94019764
44Abnormality of renal resorption (HP:0011038)2.93883762
45Myokymia (HP:0002411)2.90633063
46Impulsivity (HP:0100710)2.90630384
47Severe visual impairment (HP:0001141)2.89804056
48Abnormal rod and cone electroretinograms (HP:0008323)2.86537393
49Cholecystitis (HP:0001082)2.86466229
50Abnormal gallbladder physiology (HP:0012438)2.86466229
51Recurrent bronchitis (HP:0002837)2.86005610
52Cerebral edema (HP:0002181)2.82972559
53Congenital, generalized hypertrichosis (HP:0004540)2.82357496
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.72329987
55Tubular atrophy (HP:0000092)2.62360698
56Tubulointerstitial nephritis (HP:0001970)2.61643264
57Generalized aminoaciduria (HP:0002909)2.59908149
58Optic disc pallor (HP:0000543)2.59041875
59True hermaphroditism (HP:0010459)2.56798849
60Respiratory difficulties (HP:0002880)2.49302046
61Sclerocornea (HP:0000647)2.48893904
62Pallor (HP:0000980)2.48552548
63Hyperphosphaturia (HP:0003109)2.48389937
64Tubulointerstitial abnormality (HP:0001969)2.47697123
65Lactic acidosis (HP:0003128)2.47007473
66Aplasia/hypoplasia of the uterus (HP:0008684)2.43400205
67Dyschromatopsia (HP:0007641)2.43049990
68Increased serum lactate (HP:0002151)2.42773768
69Abnormality of midbrain morphology (HP:0002418)2.38417500
70Molar tooth sign on MRI (HP:0002419)2.38417500
71Azoospermia (HP:0000027)2.28942069
72Choroideremia (HP:0001139)2.26515410
73Absent rod-and cone-mediated responses on ERG (HP:0007688)2.26192260
74Respiratory failure (HP:0002878)2.20527288
75Tubulointerstitial fibrosis (HP:0005576)2.19308009
76Colon cancer (HP:0003003)2.17285441
77Gonadotropin excess (HP:0000837)2.16389591
78Oligodactyly (hands) (HP:0001180)2.16247880
79Anencephaly (HP:0002323)2.16038107
80Concave nail (HP:0001598)2.12816854
81Medial flaring of the eyebrow (HP:0010747)2.11830445
82Congenital malformation of the right heart (HP:0011723)2.10580044
83Double outlet right ventricle (HP:0001719)2.10580044
84Decreased central vision (HP:0007663)2.09348121
85Spastic tetraparesis (HP:0001285)2.08787753
86Pendular nystagmus (HP:0012043)2.07538277
87Hemorrhage of the eye (HP:0011885)2.05143677
88Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.02153284
89Bony spicule pigmentary retinopathy (HP:0007737)2.01807953
90Congenital stationary night blindness (HP:0007642)2.01734391
91Exercise intolerance (HP:0003546)2.00596738
92Attenuation of retinal blood vessels (HP:0007843)2.00209687
93Dynein arm defect of respiratory motile cilia (HP:0012255)13.4555585
94Absent/shortened dynein arms (HP:0200106)13.4555585
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6697227
96Tetany (HP:0001281)1.95315305
97Type II lissencephaly (HP:0007260)1.95210912
98Leukodystrophy (HP:0002415)1.94471984
99Hypoplastic left heart (HP:0004383)1.94046820
100Neurofibrillary tangles (HP:0002185)1.90850821
101Chronic hepatic failure (HP:0100626)1.90252544
102Rib fusion (HP:0000902)1.82383828
103Limb dystonia (HP:0002451)1.79776023
104Hyperthyroidism (HP:0000836)1.78872842
105Lethargy (HP:0001254)1.78362311
106Focal motor seizures (HP:0011153)1.78253638
107Decreased electroretinogram (ERG) amplitude (HP:0000654)1.77230758
108Polydipsia (HP:0001959)1.77028973
109Abnormal drinking behavior (HP:0030082)1.77028973
110Male pseudohermaphroditism (HP:0000037)1.75828248
111Heterotopia (HP:0002282)1.75032573
112Maternal diabetes (HP:0009800)1.74906511
113Renal cortical cysts (HP:0000803)1.74106948
114Absent thumb (HP:0009777)1.72981010
115Gait imbalance (HP:0002141)1.72004008
116Abnormal urine phosphate concentration (HP:0012599)1.70399032
117X-linked dominant inheritance (HP:0001423)1.68964844
118Unilateral renal agenesis (HP:0000122)1.67467846
119Stage 5 chronic kidney disease (HP:0003774)1.65751508
120Renal tubular dysfunction (HP:0000124)1.64837791
121Asymmetric septal hypertrophy (HP:0001670)1.64242209
122Abnormality of renal excretion (HP:0011036)1.63155241
123Postaxial foot polydactyly (HP:0001830)1.62429896
124Abolished electroretinogram (ERG) (HP:0000550)1.62299706
125Hypoplastic heart (HP:0001961)1.62146872
126Abnormal biliary tract physiology (HP:0012439)1.61457586
127Bile duct proliferation (HP:0001408)1.61457586
128Bell-shaped thorax (HP:0001591)1.61451549
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60406888
130Congenital hepatic fibrosis (HP:0002612)1.58000141
131Cerebral inclusion bodies (HP:0100314)1.54510771
132Easy fatigability (HP:0003388)1.52395654
133Bundle branch block (HP:0011710)1.51599587
134Abnormality of the renal cortex (HP:0011035)1.50950610
135Exercise-induced myalgia (HP:0003738)1.49508783
136Hypercholesterolemia (HP:0003124)1.49425251
137Constricted visual fields (HP:0001133)1.46355999
138Short ribs (HP:0000773)1.46053692
139Aplasia/Hypoplasia of the lens (HP:0008063)1.45545790
140Myoglobinuria (HP:0002913)1.44553773
141Abnormal urine output (HP:0012590)1.41828245
142Sensory axonal neuropathy (HP:0003390)1.41107533
143Abnormality of the neuromuscular junction (HP:0003398)1.40325162
144Fatigable weakness (HP:0003473)1.40325162
145Oculomotor apraxia (HP:0000657)1.39154023
146Loss of speech (HP:0002371)1.32928737
147Rhabdomyolysis (HP:0003201)1.32854938
148Renal dysplasia (HP:0000110)1.32798874
149Deformed sella turcica (HP:0002681)1.32189019
150Hemiparesis (HP:0001269)1.31952133
151Abnormality of dentin (HP:0010299)1.30103686
152Abnormality of the dental root (HP:0006486)1.26308139
153Taurodontia (HP:0000679)1.26308139
154Abnormality of permanent molar morphology (HP:0011071)1.26308139
155Postaxial hand polydactyly (HP:0001162)1.25772114
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25277970
157Absent epiphyses (HP:0010577)1.25277970
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.23070746
159Neoplasm of the heart (HP:0100544)1.22304305
160Cystic liver disease (HP:0006706)1.21905657
161Generalized muscle weakness (HP:0003324)1.21786259
162Chronic sinusitis (HP:0011109)1.21575911
163Cleft eyelid (HP:0000625)1.19895662
164Abnormality of the dental pulp (HP:0006479)1.19882679
165Exercise-induced muscle cramps (HP:0003710)1.19574146
166Abnormal ventriculo-arterial connection (HP:0011563)1.19188961
167Transposition of the great arteries (HP:0001669)1.19188961
168Abnormal connection of the cardiac segments (HP:0011545)1.19188961
169Facial cleft (HP:0002006)1.18748453
170Cerebellar dysplasia (HP:0007033)1.18690053
171Truncal obesity (HP:0001956)1.17084048
172Abnormality of molar morphology (HP:0011070)1.14891677
173Abnormality of molar (HP:0011077)1.14891677
174Polymicrogyria (HP:0002126)1.14571058
175Short femoral neck (HP:0100864)1.13749418
176Polyuria (HP:0000103)1.13187935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.47990838
2PDK47.47990838
3TESK17.40445555
4PRKD35.68602921
5ICK5.06065721
6PDK24.79157467
7VRK24.00814713
8TLK13.76340614
9MAP4K23.36602663
10STK163.22156290
11NUAK12.94800747
12NME22.45948738
13TNIK2.35025981
14PTK2B2.20904252
15STK382.08785514
16INSRR2.08023770
17WNK42.07086006
18ADRBK22.04830868
19STK391.98472439
20CASK1.97875528
21TAF11.94817224
22BCKDK1.92957619
23TXK1.84984684
24DYRK1B1.84048856
25VRK11.80269245
26DYRK21.78486563
27ZAK1.71539663
28NEK21.64171759
29BMPR1B1.58290526
30GRK11.54522730
31TAOK31.52715230
32MARK11.50328598
33PNCK1.49647819
34NME11.38998564
35GRK51.36219375
36PDK11.34783853
37BUB11.32730513
38EPHB21.29679570
39FRK1.23308986
40PHKG11.09863655
41PHKG21.09863655
42MAP2K21.09405351
43GRK71.07187189
44IKBKB1.01868618
45WNK31.00991325
46GRK60.99697075
47TIE10.99556965
48ABL20.96797987
49RIPK40.96795531
50PDPK10.95887244
51DYRK30.94565738
52MAP2K70.94187676
53CSNK1G30.93241414
54CCNB10.91760039
55CDK190.90874806
56TRIM280.90753523
57CDK80.90057551
58FES0.87025577
59OXSR10.84166348
60PLK20.83721004
61MAPK150.83327381
62CSNK1G20.81655715
63EEF2K0.79036785
64IRAK10.78927862
65SIK20.76541934
66TYRO30.75956447
67CDC70.75820371
68ADRBK10.74330530
69STK240.73983941
70CAMK10.72365617
71PASK0.71812388
72WNK10.69647355
73CSNK1G10.68378690
74ILK0.64653700
75TESK20.63962620
76CSNK1A10.62271010
77RPS6KA50.61131389
78PAK30.61042715
79MST40.59764381
80MAP3K120.57895969
81PINK10.57433731
82STK30.54876188
83CDK30.54848262
84CHEK20.54563760
85MAP2K60.53547982
86NTRK30.53483780
87TTK0.53299598
88IRAK20.52393292
89MINK10.50047079
90TGFBR10.50021147
91PRKCI0.48761489
92PLK30.47691847
93PAK10.47303390
94MUSK0.47101392
95CSNK1A1L0.46495434
96PRKACA0.46327386
97PRKCE0.43175003
98NTRK20.42507238
99MAP3K40.42289782
100NLK0.40948927
101MAPK130.40272924
102EIF2AK20.39826135
103CSNK1E0.39817070
104PRKCG0.37393239
105LMTK20.36613821
106CAMK1G0.36153521
107MAP3K100.35988668
108MAPKAPK50.34131415
109MAP3K110.33917860
110LIMK10.33646982
111PRKACB0.32661808
112DYRK1A0.32019430
113STK38L0.31661535
114CHEK10.31256203
115AURKB0.31130015
116PAK40.31048882
117PAK20.29796873
118MARK20.27591785
119PRKCQ0.23611411
120ATM0.22862947
121PRKCZ0.22146670
122PRKAA10.22041999
123BRAF0.21689493
124CAMKK10.21269038
125PIM10.20929522
126MTOR0.20879719
127CLK10.20519955
128CSF1R0.19863552
129CDK150.19732510
130CDK180.17182545
131ATR0.16569733
132ZAP700.14925455
133CDK11A0.14786728
134RPS6KB10.12068387
135NEK60.12066703
136PRKG20.12048579
137MAP4K10.11639156
138CDK140.11043795
139RPS6KA10.11022379
140PRKCD0.08097365
141CSNK2A10.07831172
142PLK10.07458089
143CDK60.06565047
144GSK3B0.06528945
145PIM20.05932341
146BRSK20.05258349
147STK100.04775672
148ARAF0.03301354
149PRKACG0.03175141
150MAPK80.02592319
151CAMK2A0.01956493
152BRSK10.01748091
153PKN10.01449489
154CDK20.01349872
155PRKCB0.00869791
156PRKCA0.00761845
157CDK10.00719391
158WEE10.00318544
159RPS6KA3-0.0417817
160TRIB3-0.0380728
161AURKA-0.0374100
162STK11-0.0334731
163MAP3K1-0.0327801
164MARK3-0.0258481
165MAP3K5-0.0222255
166CSK-0.0218403
167EGFR-0.0173345
168CSNK2A2-0.0167641
169TBK1-0.0134151
170CDK4-0.0112311
171PRKG1-0.0066630
172YES1-0.0056402
173PLK4-0.0033380
174CSNK1D-0.0011928

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.96425146
2Oxidative phosphorylation_Homo sapiens_hsa001905.48343799
3Fatty acid biosynthesis_Homo sapiens_hsa000615.10111567
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.50361114
5Parkinsons disease_Homo sapiens_hsa050124.41402585
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.38988153
7Linoleic acid metabolism_Homo sapiens_hsa005913.27828240
8Alzheimers disease_Homo sapiens_hsa050103.21505923
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.06063505
10Pyruvate metabolism_Homo sapiens_hsa006202.97999685
11Vitamin B6 metabolism_Homo sapiens_hsa007502.86739290
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.77082793
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.74456573
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.65183761
15RNA polymerase_Homo sapiens_hsa030202.43970692
16Glucagon signaling pathway_Homo sapiens_hsa049222.36222740
17Sulfur relay system_Homo sapiens_hsa041222.26953694
18Protein export_Homo sapiens_hsa030602.19313083
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18402226
20Propanoate metabolism_Homo sapiens_hsa006402.14966365
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.14537298
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.12435902
23Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.02934945
24Glycerolipid metabolism_Homo sapiens_hsa005611.93895115
25Selenocompound metabolism_Homo sapiens_hsa004501.91548570
26PPAR signaling pathway_Homo sapiens_hsa033201.90770186
27Basal transcription factors_Homo sapiens_hsa030221.85047860
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.80582741
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80087599
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.75868710
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.74463176
32Fat digestion and absorption_Homo sapiens_hsa049751.72960509
33Proteasome_Homo sapiens_hsa030501.72422805
34Fructose and mannose metabolism_Homo sapiens_hsa000511.70805838
35Homologous recombination_Homo sapiens_hsa034401.63506739
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58967552
37Mineral absorption_Homo sapiens_hsa049781.58735932
38Fatty acid degradation_Homo sapiens_hsa000711.52736480
39Pentose phosphate pathway_Homo sapiens_hsa000301.49747475
40Ether lipid metabolism_Homo sapiens_hsa005651.49661695
41Fatty acid metabolism_Homo sapiens_hsa012121.48860498
42Amphetamine addiction_Homo sapiens_hsa050311.47294686
43Mismatch repair_Homo sapiens_hsa034301.45730445
44Oocyte meiosis_Homo sapiens_hsa041141.45379620
45Phototransduction_Homo sapiens_hsa047441.42209044
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33072045
47Carbon metabolism_Homo sapiens_hsa012001.29703497
48Cardiac muscle contraction_Homo sapiens_hsa042601.28200758
49Nicotine addiction_Homo sapiens_hsa050331.27598727
50One carbon pool by folate_Homo sapiens_hsa006701.27268230
51Dorso-ventral axis formation_Homo sapiens_hsa043201.25255232
52Butanoate metabolism_Homo sapiens_hsa006501.17841052
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.17052013
54Antigen processing and presentation_Homo sapiens_hsa046121.16662718
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14012240
56Glutathione metabolism_Homo sapiens_hsa004801.10289770
57Basal cell carcinoma_Homo sapiens_hsa052171.04147986
58Olfactory transduction_Homo sapiens_hsa047401.03405868
59Collecting duct acid secretion_Homo sapiens_hsa049661.01422107
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00532989
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.00415954
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98366634
63Hedgehog signaling pathway_Homo sapiens_hsa043400.96942059
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95294179
65Renin secretion_Homo sapiens_hsa049240.94897210
66Purine metabolism_Homo sapiens_hsa002300.93217908
67Nucleotide excision repair_Homo sapiens_hsa034200.92619735
68Arachidonic acid metabolism_Homo sapiens_hsa005900.91635778
69Peroxisome_Homo sapiens_hsa041460.90426796
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.87712312
71RNA degradation_Homo sapiens_hsa030180.86258744
72Fanconi anemia pathway_Homo sapiens_hsa034600.84481058
73Insulin secretion_Homo sapiens_hsa049110.82437497
74Systemic lupus erythematosus_Homo sapiens_hsa053220.82171908
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81982598
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80935006
77Morphine addiction_Homo sapiens_hsa050320.80575793
78Legionellosis_Homo sapiens_hsa051340.80414007
79Folate biosynthesis_Homo sapiens_hsa007900.79650658
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79385227
81Chemical carcinogenesis_Homo sapiens_hsa052040.78877200
82mRNA surveillance pathway_Homo sapiens_hsa030150.78233579
83Bile secretion_Homo sapiens_hsa049760.77420686
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77192253
85Thyroid hormone synthesis_Homo sapiens_hsa049180.77133031
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.75871805
87Base excision repair_Homo sapiens_hsa034100.75383922
88Nitrogen metabolism_Homo sapiens_hsa009100.75221763
89Estrogen signaling pathway_Homo sapiens_hsa049150.73761354
90Spliceosome_Homo sapiens_hsa030400.73568752
91Biosynthesis of amino acids_Homo sapiens_hsa012300.70973226
92Long-term potentiation_Homo sapiens_hsa047200.70196437
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68663157
94Retinol metabolism_Homo sapiens_hsa008300.65464961
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.64832330
96Tryptophan metabolism_Homo sapiens_hsa003800.64727354
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63614626
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63376035
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62405155
100GABAergic synapse_Homo sapiens_hsa047270.61849469
101Huntingtons disease_Homo sapiens_hsa050160.61599101
102Renin-angiotensin system_Homo sapiens_hsa046140.57707380
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56851405
104Pancreatic secretion_Homo sapiens_hsa049720.55861355
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54791699
106RNA transport_Homo sapiens_hsa030130.54237806
107Serotonergic synapse_Homo sapiens_hsa047260.53334998
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52955175
109Protein digestion and absorption_Homo sapiens_hsa049740.52815359
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52806442
111Salivary secretion_Homo sapiens_hsa049700.50848277
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.48437554
113ABC transporters_Homo sapiens_hsa020100.47794981
114Arginine and proline metabolism_Homo sapiens_hsa003300.45871495
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.45431734
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45255022
117Synaptic vesicle cycle_Homo sapiens_hsa047210.44640394
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44253579
119Tyrosine metabolism_Homo sapiens_hsa003500.44186143
120Regulation of autophagy_Homo sapiens_hsa041400.43639806
121Gastric acid secretion_Homo sapiens_hsa049710.43124812
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43080138
123beta-Alanine metabolism_Homo sapiens_hsa004100.42770930
124Calcium signaling pathway_Homo sapiens_hsa040200.42578628
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.42537122
126Alcoholism_Homo sapiens_hsa050340.41726182
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41704795
128Endocytosis_Homo sapiens_hsa041440.41543268
129VEGF signaling pathway_Homo sapiens_hsa043700.41262775
130SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40648347
131AMPK signaling pathway_Homo sapiens_hsa041520.40225706
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39961591
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39279399
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38945539
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38170799
136Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.37227743
137Asthma_Homo sapiens_hsa053100.36769362
138Fatty acid elongation_Homo sapiens_hsa000620.35266988
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34741114
140Sulfur metabolism_Homo sapiens_hsa009200.34468647
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33835268
142Inositol phosphate metabolism_Homo sapiens_hsa005620.31063794
143cAMP signaling pathway_Homo sapiens_hsa040240.30679260
144Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30288459
145Dopaminergic synapse_Homo sapiens_hsa047280.30231537
146Metabolic pathways_Homo sapiens_hsa011000.30020917
147Pyrimidine metabolism_Homo sapiens_hsa002400.29108879
148Rheumatoid arthritis_Homo sapiens_hsa053230.27441052
149Glutamatergic synapse_Homo sapiens_hsa047240.27239122
150B cell receptor signaling pathway_Homo sapiens_hsa046620.27037861
151Caffeine metabolism_Homo sapiens_hsa002320.22198486
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21012372
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19992336
154Cocaine addiction_Homo sapiens_hsa050300.19915914
155Measles_Homo sapiens_hsa051620.18827412
156Circadian entrainment_Homo sapiens_hsa047130.18437053
157HIF-1 signaling pathway_Homo sapiens_hsa040660.17891230
158Salmonella infection_Homo sapiens_hsa051320.14186815
159Taste transduction_Homo sapiens_hsa047420.13347741
160Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09979892
161Viral carcinogenesis_Homo sapiens_hsa052030.06800385
162Toxoplasmosis_Homo sapiens_hsa051450.06775399
163DNA replication_Homo sapiens_hsa030300.05569226

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