FRMD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mutations in this gene are associated with X-linked congenital nystagmus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of heat generation (GO:0031652)9.13056753
2cellular response to ATP (GO:0071318)8.83535320
3aminoglycoside antibiotic metabolic process (GO:0030647)8.00595548
4regulation of synapse structural plasticity (GO:0051823)7.56664429
5regulation of vitamin D biosynthetic process (GO:0060556)7.21971395
6regulation of heat generation (GO:0031650)7.16981662
7maintenance of protein location in nucleus (GO:0051457)6.98551670
8somite rostral/caudal axis specification (GO:0032525)6.94709941
9regulation of mammary gland epithelial cell proliferation (GO:0033599)6.43557698
10negative regulation of epidermis development (GO:0045683)6.37866416
11regulation of response to osmotic stress (GO:0047484)6.31270035
12adenosine receptor signaling pathway (GO:0001973)6.30129663
13regulation of fever generation (GO:0031620)6.20804987
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.14347695
15response to ATP (GO:0033198)6.09607194
16tachykinin receptor signaling pathway (GO:0007217)5.65749261
17regulation of vitamin metabolic process (GO:0030656)5.62825056
18muscle organ morphogenesis (GO:0048644)5.59188881
19negative regulation of cell aging (GO:0090344)5.53690546
20histone H4-K8 acetylation (GO:0043982)5.48572901
21histone H4-K5 acetylation (GO:0043981)5.48572901
22negative regulation of cell cycle G2/M phase transition (GO:1902750)5.48566577
23DNA strand renaturation (GO:0000733)5.46704317
24regulation of cilium movement (GO:0003352)5.42469468
25rRNA transcription (GO:0009303)5.33478385
26negative regulation of telomerase activity (GO:0051974)5.26714025
27response to dietary excess (GO:0002021)5.20191276
28regulation of nuclear cell cycle DNA replication (GO:0033262)5.14131598
29protein localization to kinetochore (GO:0034501)5.09761920
30purinergic nucleotide receptor signaling pathway (GO:0035590)5.04917631
31regulation of telomere maintenance via telomerase (GO:0032210)5.03618066
32negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.03121821
33histone H4-K12 acetylation (GO:0043983)4.92167494
34positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.88242350
35negative regulation of epidermal cell differentiation (GO:0045605)4.88195635
36hormone catabolic process (GO:0042447)4.87548363
37coenzyme catabolic process (GO:0009109)4.79103174
38regulation of skeletal muscle contraction (GO:0014819)4.76127888
39notochord development (GO:0030903)4.75689960
40phenol-containing compound catabolic process (GO:0019336)4.74773512
41positive regulation of protein kinase C signaling (GO:0090037)4.68271512
42purine ribonucleotide transport (GO:0015868)4.53547766
43vitamin A metabolic process (GO:0006776)4.51626714
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.51191613
45proline transport (GO:0015824)4.51030747
46cytidine deamination (GO:0009972)4.50230193
47cytidine metabolic process (GO:0046087)4.50230193
48cytidine catabolic process (GO:0006216)4.50230193
49regulation of MHC class I biosynthetic process (GO:0045343)4.43327190
50regulation of protein kinase A signaling (GO:0010738)4.38466196
51primitive streak formation (GO:0090009)4.36511334
52cellular modified amino acid catabolic process (GO:0042219)4.34794639
53interferon-gamma production (GO:0032609)4.34703342
54bone trabecula formation (GO:0060346)4.32790890
55nucleotide transmembrane transport (GO:1901679)4.32303846
56meiotic chromosome segregation (GO:0045132)4.26546780
57regulation of apoptotic process involved in morphogenesis (GO:1902337)4.25801021
58mitochondrion distribution (GO:0048311)4.21699696
59calcium-mediated signaling using intracellular calcium source (GO:0035584)4.21632931
60transepithelial transport (GO:0070633)4.19163014
61detection of temperature stimulus (GO:0016048)4.18288633
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.18105498
63regulation of chemokine biosynthetic process (GO:0045073)4.17976094
64positive regulation of digestive system process (GO:0060456)4.14050975
65quinone metabolic process (GO:1901661)4.13876236
66branching involved in mammary gland duct morphogenesis (GO:0060444)4.10055178
67positive regulation of chemokine biosynthetic process (GO:0045080)4.09803551
68mitotic sister chromatid segregation (GO:0000070)4.09332195
69heterochromatin organization (GO:0070828)4.08291005
70positive regulation of DNA-dependent DNA replication (GO:2000105)4.06930500
71lens fiber cell differentiation (GO:0070306)4.05985785
72nucleoside transmembrane transport (GO:1901642)4.03102316
73histone H4-K16 acetylation (GO:0043984)4.01216953
74purinergic receptor signaling pathway (GO:0035587)4.00840597
75positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.92850416
76icosanoid secretion (GO:0032309)3.88420991
77arachidonic acid secretion (GO:0050482)3.88420991
78adenine nucleotide transport (GO:0051503)3.87737565
79rRNA methylation (GO:0031167)3.86678004
80regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.86299866
81maintenance of protein localization in organelle (GO:0072595)3.84495759
82sensory perception of taste (GO:0050909)3.84426671
83negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.83330984
84positive regulation of macrophage cytokine production (GO:0060907)3.82789231
85synaptic vesicle maturation (GO:0016188)3.75556956
86phagocytosis, recognition (GO:0006910)3.71141104
87positive regulation of amino acid transport (GO:0051957)3.62457555
88response to peptidoglycan (GO:0032494)3.61359707
89behavioral response to nicotine (GO:0035095)3.60682233
90intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.58766270
91positive regulation of protein deacetylation (GO:0090312)3.57165596
92regulation of microtubule-based movement (GO:0060632)3.55683390
93nuclear pore complex assembly (GO:0051292)3.55031469
94chromatin assembly (GO:0031497)3.53772343
95negative regulation of telomere maintenance (GO:0032205)3.51216689
96protein polyglutamylation (GO:0018095)3.51046430
97regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.49950806
98intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.49076247
99microtubule severing (GO:0051013)3.46228358
100positive regulation of histone deacetylation (GO:0031065)3.46048999
101positive regulation of prostaglandin secretion (GO:0032308)3.45394277
102peptidyl-glutamic acid carboxylation (GO:0017187)3.45065669
103protein carboxylation (GO:0018214)3.45065669
104regulation of cytokine production involved in inflammatory response (GO:1900015)3.44891787
105protein localization to chromosome, centromeric region (GO:0071459)3.44877040
106regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.44779202
107retinoic acid receptor signaling pathway (GO:0048384)3.42168297
108synaptic transmission, cholinergic (GO:0007271)3.41534730
109negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.41179984
110pre-miRNA processing (GO:0031054)3.40925604
111positive regulation of nitric oxide biosynthetic process (GO:0045429)3.40231245
112sialylation (GO:0097503)3.39040865
113cofactor transport (GO:0051181)3.36349498
114regulation of translation in response to stress (GO:0043555)3.35395272
115sulfur amino acid catabolic process (GO:0000098)3.33523186
116cell fate commitment involved in formation of primary germ layer (GO:0060795)3.33259703
117cardiovascular system development (GO:0072358)3.32996332
118pyrimidine nucleobase catabolic process (GO:0006208)3.32696357
119sister chromatid segregation (GO:0000819)3.32239914
120rRNA modification (GO:0000154)3.32132138
121positive regulation vascular endothelial growth factor production (GO:0010575)3.30837407
122regulation of prostaglandin secretion (GO:0032306)3.29024516
123positive regulation of muscle cell apoptotic process (GO:0010661)3.28773103
124cellular response to nicotine (GO:0071316)3.26744308
125regulation of telomere maintenance (GO:0032204)3.26461313
126DNA replication-dependent nucleosome organization (GO:0034723)3.26457292
127DNA replication-dependent nucleosome assembly (GO:0006335)3.26457292
128anterior/posterior axis specification (GO:0009948)3.26423385
129pyrimidine ribonucleoside catabolic process (GO:0046133)3.25304868
130regulation of glucose import in response to insulin stimulus (GO:2001273)3.24257166
131purine nucleotide transport (GO:0015865)3.21708944
132regulation of vascular endothelial growth factor production (GO:0010574)3.21601438
133intestinal epithelial cell development (GO:0060576)3.20488710
134phosphatidylinositol 3-kinase signaling (GO:0014065)3.20216492
135GDP-mannose metabolic process (GO:0019673)3.18475827
136signal transduction involved in regulation of gene expression (GO:0023019)3.17832884
137G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.15223318
138lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15162569
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.14219015
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.14006484
141regulation of interleukin-2 biosynthetic process (GO:0045076)3.11984319
142protein insertion into membrane (GO:0051205)3.11624298
143ventricular system development (GO:0021591)3.11399517
144regulation of phospholipid biosynthetic process (GO:0071071)3.10227267
145heme transport (GO:0015886)3.06184194
146icosanoid transport (GO:0071715)3.04772511
147fatty acid derivative transport (GO:1901571)3.04772511
148peristalsis (GO:0030432)3.04415313
149negative regulation of interleukin-2 production (GO:0032703)3.04338560
150melanin biosynthetic process (GO:0042438)3.04102996
151regulation of telomerase activity (GO:0051972)3.03343917
152DNA double-strand break processing (GO:0000729)3.01521134
153regulation of heterotypic cell-cell adhesion (GO:0034114)3.01439645
154positive regulation of acute inflammatory response (GO:0002675)3.00164293
155positive regulation of NF-kappaB import into nucleus (GO:0042346)2.98550464
156UV protection (GO:0009650)2.97744658
157oligosaccharide catabolic process (GO:0009313)2.96764389
158water-soluble vitamin biosynthetic process (GO:0042364)2.91423460
159urinary tract smooth muscle contraction (GO:0014848)2.90287225
160regulation of interleukin-12 biosynthetic process (GO:0045075)2.89891647
161kynurenine metabolic process (GO:0070189)2.88334707
162regulation of chronic inflammatory response (GO:0002676)2.85338903
163positive regulation of alcohol biosynthetic process (GO:1902932)2.84727923
164positive regulation of organic acid transport (GO:0032892)2.84515969
165regulation of glutamate secretion (GO:0014048)2.80131690
166regulation of nitric oxide biosynthetic process (GO:0045428)2.79426633
167regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78172101
168regulation of interleukin-6 biosynthetic process (GO:0045408)2.77830488
169melanin metabolic process (GO:0006582)2.77317502
170sphingomyelin metabolic process (GO:0006684)2.75323618
171neuromuscular synaptic transmission (GO:0007274)2.73884770
172ganglioside metabolic process (GO:0001573)2.72748324
173regulation of NFAT protein import into nucleus (GO:0051532)2.72286217
174positive regulation of steroid biosynthetic process (GO:0010893)2.71648304
175detection of light stimulus involved in sensory perception (GO:0050962)2.69337541
176detection of light stimulus involved in visual perception (GO:0050908)2.69337541
177purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.67580738
178ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.67580738
179nucleoside bisphosphate biosynthetic process (GO:0033866)2.67580738
180iron coordination entity transport (GO:1901678)2.66340487
181positive regulation of T-helper cell differentiation (GO:0045624)2.65390050
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.63533807
183purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.63533807
184regulation of interferon-alpha production (GO:0032647)2.58576673
185negative regulation of tumor necrosis factor production (GO:0032720)2.56822803
186regulation of interferon-beta biosynthetic process (GO:0045357)2.56391000
187positive regulation of transcription factor import into nucleus (GO:0042993)2.55220753
188regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.54348090
189doxorubicin metabolic process (GO:0044598)12.4087071
190daunorubicin metabolic process (GO:0044597)12.4087071
191polyketide metabolic process (GO:0030638)12.4087071

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.42361924
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse7.20456090
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse7.20456090
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse7.20456090
5VDR_21846776_ChIP-Seq_THP-1_Human4.40302105
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.88458517
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.34662710
8SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.24039190
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.01249614
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.99767552
11P68_20966046_ChIP-Seq_HELA_Human2.71162714
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.69778692
13MAF_26560356_Chip-Seq_TH2_Human2.69152298
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60266586
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.60032455
16BCL6_27268052_Chip-Seq_Bcells_Human2.49835038
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.48008256
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42566419
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39998255
20VDR_24763502_ChIP-Seq_THP-1_Human2.37589850
21TCF3_18692474_ChIP-Seq_MEFs_Mouse2.30567553
22BCOR_27268052_Chip-Seq_Bcells_Human2.29840691
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28168809
24E2F1_20622854_ChIP-Seq_HELA_Human2.21549454
25NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.14039118
26CTCF_27219007_Chip-Seq_Bcells_Human2.08743920
27DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.06261176
28RXRA_24833708_ChIP-Seq_LIVER_Mouse2.05433612
29IRF8_22096565_ChIP-ChIP_GC-B_Human2.02901180
30MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.01707690
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.00943614
32IRF1_19129219_ChIP-ChIP_H3396_Human2.00293651
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.00064948
34RARB_24833708_ChIP-Seq_LIVER_Mouse1.93645224
35NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.91399706
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.91076943
37HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89917511
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88418395
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.87039207
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86408771
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.83355190
42PHF8_20622854_ChIP-Seq_HELA_Human1.82840628
43NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.82680250
44POU5F1_16518401_ChIP-PET_MESCs_Mouse1.82024591
45EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81598496
46MAF_26560356_Chip-Seq_TH1_Human1.80644273
47E2F7_22180533_ChIP-Seq_HELA_Human1.80616758
48TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.76851756
49XRN2_22483619_ChIP-Seq_HELA_Human1.76138603
50CDX2_20551321_ChIP-Seq_CACO-2_Human1.74449541
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.70940346
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.70851298
53RXR_22158963_ChIP-Seq_LIVER_Mouse1.70772337
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70302804
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70160280
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67613924
57E2F1_17053090_ChIP-ChIP_MCF-7_Human1.63009914
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62206595
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.60652146
60SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59787549
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.59030942
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.58654376
63PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.56569838
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55674113
65CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.55557380
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.55535058
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.54756459
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.54169898
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.52513748
70RARA_24833708_ChIP-Seq_LIVER_Mouse1.48867962
71PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46609395
72ELF1_20517297_ChIP-Seq_JURKAT_Human1.46419091
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45525195
74GATA1_22025678_ChIP-Seq_K562_Human1.43140032
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40902169
76RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40504528
77NANOG_18692474_ChIP-Seq_MESCs_Mouse1.40462265
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.38986082
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37871862
80SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37813487
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.37392141
82CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36854121
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.36327972
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36211239
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35012757
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32366862
87OCT4_20526341_ChIP-Seq_ESCs_Human1.30894670
88SA1_27219007_Chip-Seq_Bcells_Human1.30407152
89NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.30286503
90NANOG_18692474_ChIP-Seq_MEFs_Mouse1.29504957
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27235135
92KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27194920
93ETS1_21867929_ChIP-Seq_TH2_Mouse1.26481325
94P53_21459846_ChIP-Seq_SAOS-2_Human1.26145429
95SA1_27219007_Chip-Seq_ERYTHROID_Human1.26092151
96TAF2_19829295_ChIP-Seq_ESCs_Human1.25114941
97NANOG_16518401_ChIP-PET_MESCs_Mouse1.24315638
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24052749
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23985939
100UTX_26944678_Chip-Seq_JUKART_Human1.23628927
101POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23134290
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.22618520
103FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22563501
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.21261102
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19997898
106DCP1A_22483619_ChIP-Seq_HELA_Human1.19887337
107EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19185277
108ERA_21632823_ChIP-Seq_H3396_Human1.18927369
109EWS_26573619_Chip-Seq_HEK293_Human1.18453038
110FOXP1_21924763_ChIP-Seq_HESCs_Human1.18162261
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17662624
112TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17624238
113CTCF_20526341_ChIP-Seq_ESCs_Human1.17558283
114DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16452359
115MYC_19829295_ChIP-Seq_ESCs_Human1.16035363
116KDM2B_26808549_Chip-Seq_K562_Human1.15567963
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.14563351
118TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14504446
119TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13594275
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13281226
121STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12391376
122TP53_20018659_ChIP-ChIP_R1E_Mouse1.12251013
123PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11639662
124RUNX1_27514584_Chip-Seq_MCF-7_Human1.11542142
125RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10035934
126SMC4_20622854_ChIP-Seq_HELA_Human1.09997163
127P300_27268052_Chip-Seq_Bcells_Human1.09024950
128SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08627466
129TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08402760
130ESR1_21235772_ChIP-Seq_MCF-7_Human1.07892087
131RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.06789164
132PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05961080
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05957047
134BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.05553167
135RNF2_27304074_Chip-Seq_NSC_Mouse1.05180009
136TP53_22127205_ChIP-Seq_IMR90_Human1.04724911
137OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04513745
138E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04443615
139KDM2B_26808549_Chip-Seq_DND41_Human1.04162377
140ESR2_21235772_ChIP-Seq_MCF-7_Human1.03723525
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03606310
142NANOG_20526341_ChIP-Seq_ESCs_Human1.02089311
143SPI1_26923725_Chip-Seq_HPCs_Mouse1.00884568
144POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00510707
145NANOG_16153702_ChIP-ChIP_HESCs_Human1.00409688
146FUS_26573619_Chip-Seq_HEK293_Human0.99663691
147NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92669654
148SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90993300
149EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90276769
150RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90276769
151STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89735010
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.87450766
153NCOR1_26117541_ChIP-Seq_K562_Human0.86949203
154TCF7_22412390_ChIP-Seq_EML_Mouse0.83700086
155NOTCH1_21737748_ChIP-Seq_TLL_Human0.82490074
156YY1_21170310_ChIP-Seq_MESCs_Mouse0.81856578
157TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81502182
158LXR_22292898_ChIP-Seq_THP-1_Human0.81090332
159ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77608752
160THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77303243
161FOXO3_23340844_ChIP-Seq_DLD1_Human0.77250981
162MYC_22102868_ChIP-Seq_BL_Human0.77184262
163SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77026202
164SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76520244
165SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.74749770
166EOMES_21245162_ChIP-Seq_HESCs_Human0.74438856
167NANOG_21062744_ChIP-ChIP_HESCs_Human0.72707146
168RACK7_27058665_Chip-Seq_MCF-7_Human0.71420783
169ELK4_26923725_Chip-Seq_MESODERM_Mouse0.71072990
170STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.70449296
171ELK3_25401928_ChIP-Seq_HUVEC_Human0.70250294
172EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.70003940
173CTCF_21964334_Chip-Seq_Bcells_Human0.69749681
174PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69727211
175CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.69619815
176TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.68516003
177RARB_27405468_Chip-Seq_BRAIN_Mouse0.68009310
178DPY_21335234_ChIP-Seq_ESCs_Mouse0.67159534
179KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.66646711
180HOXB7_26014856_ChIP-Seq_BT474_Human0.66451991
181SMAD3_21741376_ChIP-Seq_HESCs_Human0.65690855
182SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.64762812
183ESET_19884257_ChIP-Seq_ESCs_Mouse0.64511144
184WT1_19549856_ChIP-ChIP_CCG9911_Human0.63691846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.89612799
2MP0005171_absent_coat_pigmentation5.55106763
3MP0001986_abnormal_taste_sensitivity5.41259032
4MP0002254_reproductive_system_inflammat5.25594555
5MP0003303_peritoneal_inflammation4.85454519
6MP0005174_abnormal_tail_pigmentation4.80070763
7MP0003136_yellow_coat_color4.68800762
8MP0004858_abnormal_nervous_system4.50871506
9MP0005423_abnormal_somatic_nervous4.42226491
10MP0006292_abnormal_olfactory_placode4.10269487
11MP0004264_abnormal_extraembryonic_tissu4.04159883
12MP0005394_taste/olfaction_phenotype3.54572335
13MP0005499_abnormal_olfactory_system3.54572335
14MP0005075_abnormal_melanosome_morpholog3.49220919
15MP0003122_maternal_imprinting3.40841184
16MP0001968_abnormal_touch/_nociception3.36201746
17MP0003890_abnormal_embryonic-extraembry3.19923040
18MP0003195_calcinosis2.92500383
19MP0003705_abnormal_hypodermis_morpholog2.89815771
20MP0002736_abnormal_nociception_after2.88434692
21MP0002332_abnormal_exercise_endurance2.85225213
22MP0010386_abnormal_urinary_bladder2.84508235
23MP0001188_hyperpigmentation2.72130068
24MP0005257_abnormal_intraocular_pressure2.68782745
25MP0008875_abnormal_xenobiotic_pharmacok2.56686510
26MP0003121_genomic_imprinting2.40757821
27MP0005409_darkened_coat_color2.34011913
28MP0006035_abnormal_mitochondrial_morpho2.19116162
29MP0009278_abnormal_bone_marrow2.14456656
30MP0003183_abnormal_peptide_metabolism2.14155712
31MP0005167_abnormal_blood-brain_barrier2.10997200
32MP0001502_abnormal_circadian_rhythm2.07548668
33MP0000015_abnormal_ear_pigmentation2.04907724
34MP0005645_abnormal_hypothalamus_physiol2.00165022
35MP0003938_abnormal_ear_development1.98776894
36MP0002638_abnormal_pupillary_reflex1.98504897
37MP0001756_abnormal_urination1.97904863
38MP0002653_abnormal_ependyma_morphology1.89573100
39MP0009764_decreased_sensitivity_to1.84902237
40MP0002148_abnormal_hypersensitivity_rea1.83862187
41MP0008057_abnormal_DNA_replication1.83819588
42MP0002735_abnormal_chemical_nociception1.80912442
43MP0005083_abnormal_biliary_tract1.80160149
44MP0008961_abnormal_basal_metabolism1.79173991
45MP0006082_CNS_inflammation1.74428508
46MP0005535_abnormal_body_temperature1.73225050
47MP0000678_abnormal_parathyroid_gland1.70585830
48MP0004043_abnormal_pH_regulation1.66757417
49MP0002127_abnormal_cardiovascular_syste1.63599690
50MP0003453_abnormal_keratinocyte_physiol1.59709579
51MP0003656_abnormal_erythrocyte_physiolo1.57210937
52MP0003787_abnormal_imprinting1.55897411
53MP0003123_paternal_imprinting1.52010088
54MP0010352_gastrointestinal_tract_polyps1.50986117
55MP0004957_abnormal_blastocyst_morpholog1.49471939
56MP0002233_abnormal_nose_morphology1.48889349
57MP0002932_abnormal_joint_morphology1.47702053
58MP0001849_ear_inflammation1.47551815
59MP0000751_myopathy1.46555585
60MP0005365_abnormal_bile_salt1.44153762
61MP0002277_abnormal_respiratory_mucosa1.43320729
62MP0009785_altered_susceptibility_to1.39105153
63MP0002139_abnormal_hepatobiliary_system1.39051343
64MP0000762_abnormal_tongue_morphology1.39006604
65MP0003283_abnormal_digestive_organ1.37855313
66MP0005380_embryogenesis_phenotype1.36328254
67MP0001672_abnormal_embryogenesis/_devel1.36328254
68MP0008004_abnormal_stomach_pH1.34453048
69MP0001348_abnormal_lacrimal_gland1.34075202
70MP0002088_abnormal_embryonic_growth/wei1.33534609
71MP0003984_embryonic_growth_retardation1.30486104
72MP0010030_abnormal_orbit_morphology1.28061446
73MP0003448_altered_tumor_morphology1.27882521
74MP0000049_abnormal_middle_ear1.27846666
75MP0001293_anophthalmia1.27815971
76MP0002092_abnormal_eye_morphology1.27430415
77MP0003137_abnormal_impulse_conducting1.25281569
78MP0004270_analgesia1.24434386
79MP0000569_abnormal_digit_pigmentation1.23365980
80MP0008789_abnormal_olfactory_epithelium1.23278043
81MP0002114_abnormal_axial_skeleton1.16994810
82MP0005248_abnormal_Harderian_gland1.15594850
83MP0005332_abnormal_amino_acid1.15497491
84MP0000428_abnormal_craniofacial_morphol1.14657052
85MP0004381_abnormal_hair_follicle1.06967182
86MP0005584_abnormal_enzyme/coenzyme_acti1.05719983
87MP0002249_abnormal_larynx_morphology1.04993263
88MP0001835_abnormal_antigen_presentation1.04745394
89MP0005266_abnormal_metabolism1.02246126
90MP0003119_abnormal_digestive_system1.02019570
91MP0001970_abnormal_pain_threshold1.00631831
92MP0000538_abnormal_urinary_bladder0.98624106
93MP0002006_tumorigenesis0.97908062
94MP0008770_decreased_survivor_rate0.97295647
95MP0002970_abnormal_white_adipose0.97293745
96MP0004947_skin_inflammation0.97143774
97MP0004133_heterotaxia0.95385665
98MP0005058_abnormal_lysosome_morphology0.94987087
99MP0000749_muscle_degeneration0.94112638
100MP0002086_abnormal_extraembryonic_tissu0.93132336
101MP0003436_decreased_susceptibility_to0.92678151
102MP0000432_abnormal_head_morphology0.89917972
103MP0005508_abnormal_skeleton_morphology0.89610798
104MP0003755_abnormal_palate_morphology0.89323849
105MP0003315_abnormal_perineum_morphology0.88367437
106MP0001270_distended_abdomen0.88136684
107MP0000350_abnormal_cell_proliferation0.87750114
108MP0002419_abnormal_innate_immunity0.87279702
109MP0003935_abnormal_craniofacial_develop0.86965290
110MP0002751_abnormal_autonomic_nervous0.86231000
111MP0005000_abnormal_immune_tolerance0.84463705
112MP0004019_abnormal_vitamin_homeostasis0.82973958
113MP0005391_vision/eye_phenotype0.82441356
114MP0005166_decreased_susceptibility_to0.81210725
115MP0000750_abnormal_muscle_regeneration0.80737555
116MP0005197_abnormal_uvea_morphology0.79568716
117MP0004484_altered_response_of0.79276039
118MP0002269_muscular_atrophy0.77963941
119MP0001765_abnormal_ion_homeostasis0.76785343
120MP0004130_abnormal_muscle_cell0.76638058
121MP0002116_abnormal_craniofacial_bone0.76286392
122MP0002085_abnormal_embryonic_tissue0.74580684
123MP0002132_abnormal_respiratory_system0.73727481
124MP0005085_abnormal_gallbladder_physiolo0.73189201
125MP0003724_increased_susceptibility_to0.72999022
126MP0005410_abnormal_fertilization0.72574366
127MP0005025_abnormal_response_to0.72409857
128MP0004272_abnormal_basement_membrane0.71966048
129MP0005397_hematopoietic_system_phenotyp0.71936380
130MP0001545_abnormal_hematopoietic_system0.71936380
131MP0008874_decreased_physiological_sensi0.71603421
132MP0002396_abnormal_hematopoietic_system0.70738147
133MP0002925_abnormal_cardiovascular_devel0.70271987
134MP0002084_abnormal_developmental_patter0.69759088
135MP0008469_abnormal_protein_level0.68790422
136MP0000858_altered_metastatic_potential0.68353056
137MP0009046_muscle_twitch0.67991123
138MP0004510_myositis0.67855916
139MP0002572_abnormal_emotion/affect_behav0.67608757
140MP0009840_abnormal_foam_cell0.66895933
141MP0002752_abnormal_somatic_nervous0.65748632
142MP0000371_diluted_coat_color0.65387913
143MP0001486_abnormal_startle_reflex0.65070698
144MP0009250_abnormal_appendicular_skeleto0.64799640
145MP0004197_abnormal_fetal_growth/weight/0.64381050
146MP0002063_abnormal_learning/memory/cond0.63906021
147MP0000163_abnormal_cartilage_morphology0.63903232
148MP0000013_abnormal_adipose_tissue0.63846053
149MP0003075_altered_response_to0.63671072
150MP0003172_abnormal_lysosome_physiology0.62971803
151MP0010155_abnormal_intestine_physiology0.62010200
152MP0003868_abnormal_feces_composition0.61915708
153MP0001542_abnormal_bone_strength0.61900456
154MP0004883_abnormal_blood_vessel0.61621367
155MP0002909_abnormal_adrenal_gland0.61232694
156MP0001243_abnormal_dermal_layer0.61149390
157MP0002723_abnormal_immune_serum0.60860235
158MP0003942_abnormal_urinary_system0.60117180
159MP0002452_abnormal_antigen_presenting0.60091777
160MP0001845_abnormal_inflammatory_respons0.59888842
161MP0002081_perinatal_lethality0.59677193
162MP0000343_altered_response_to0.59332486
163MP0010368_abnormal_lymphatic_system0.59177160
164MP0000955_abnormal_spinal_cord0.58804730
165MP0001663_abnormal_digestive_system0.57457460
166MP0002998_abnormal_bone_remodeling0.57121015
167MP0009643_abnormal_urine_homeostasis0.56991042
168MP0004085_abnormal_heartbeat0.56941259
169MP0005551_abnormal_eye_electrophysiolog0.55910398
170MP0002108_abnormal_muscle_morphology0.55652650
171MP0003091_abnormal_cell_migration0.55410390
172MP0003806_abnormal_nucleotide_metabolis0.54865476
173MP0005623_abnormal_meninges_morphology0.53739967
174MP0009703_decreased_birth_body0.53619510
175MP0001191_abnormal_skin_condition0.53331012
176MP0005023_abnormal_wound_healing0.53167649
177MP0005084_abnormal_gallbladder_morpholo0.52637674
178MP0002733_abnormal_thermal_nociception0.52207201
179MP0002405_respiratory_system_inflammati0.52056021
180MP0005253_abnormal_eye_physiology0.51749967
181MP0001664_abnormal_digestion0.51662142
182MP0000759_abnormal_skeletal_muscle0.51642364
183MP0003861_abnormal_nervous_system0.51526953
184MP0000470_abnormal_stomach_morphology0.50474405
185MP0005310_abnormal_salivary_gland0.50259378
186MP0003221_abnormal_cardiomyocyte_apopto0.50237490
187MP0001764_abnormal_homeostasis0.47766593
188MP0002136_abnormal_kidney_physiology0.46375020
189MP0004924_abnormal_behavior0.46267896

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.73874579
2Hypochromic microcytic anemia (HP:0004840)6.98259113
3Hepatoblastoma (HP:0002884)6.49728794
4Abnormality of the lower motor neuron (HP:0002366)5.28536763
5Multiple enchondromatosis (HP:0005701)5.15830086
6Attenuation of retinal blood vessels (HP:0007843)4.68084526
7Unilateral renal agenesis (HP:0000122)4.67255603
8Thin bony cortex (HP:0002753)4.53341066
9Rib fusion (HP:0000902)4.50567136
10Septo-optic dysplasia (HP:0100842)4.21398111
11Poikiloderma (HP:0001029)4.05411599
12Congenital stationary night blindness (HP:0007642)4.03977320
13Bony spicule pigmentary retinopathy (HP:0007737)4.03960212
14Ependymoma (HP:0002888)4.00959350
15Facial diplegia (HP:0001349)3.99760251
16Testicular atrophy (HP:0000029)3.94939917
17Popliteal pterygium (HP:0009756)3.86435631
18Hypophosphatemic rickets (HP:0004912)3.73261036
19Delayed epiphyseal ossification (HP:0002663)3.71673338
20Facial hemangioma (HP:0000329)3.71376274
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.71368889
22Ulnar bowing (HP:0003031)3.68543934
23Annular pancreas (HP:0001734)3.67624237
24Chorioretinal atrophy (HP:0000533)3.66645256
25Enlarged epiphyses (HP:0010580)3.62699565
26Nephroblastoma (Wilms tumor) (HP:0002667)3.62079045
27Prolonged partial thromboplastin time (HP:0003645)3.60517080
28Turricephaly (HP:0000262)3.57727776
29Neoplasm of striated muscle (HP:0009728)3.56727940
30Hypoplasia of the fovea (HP:0007750)3.56616384
31Aplasia/Hypoplasia of the fovea (HP:0008060)3.56616384
32Choanal stenosis (HP:0000452)3.53725383
33Embryonal renal neoplasm (HP:0011794)3.52388094
34Akinesia (HP:0002304)3.42108566
35Ragged-red muscle fibers (HP:0003200)3.30978227
36Anomalous pulmonary venous return (HP:0010772)3.27088347
37Abnormality of the salivary glands (HP:0010286)3.25604903
38Rhabdomyosarcoma (HP:0002859)3.23017029
39Hyperinsulinemic hypoglycemia (HP:0000825)3.22295339
40Birth length less than 3rd percentile (HP:0003561)3.21083215
41Hyperventilation (HP:0002883)3.19895824
42Sensory axonal neuropathy (HP:0003390)3.18176229
43Fused cervical vertebrae (HP:0002949)3.13475684
44Coronal craniosynostosis (HP:0004440)3.09239835
45Astrocytoma (HP:0009592)3.06567032
46Abnormality of the astrocytes (HP:0100707)3.06567032
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.03273580
48Short chin (HP:0000331)2.99732658
49Squamous cell carcinoma (HP:0002860)2.95529335
50Rectovaginal fistula (HP:0000143)2.92967983
51Rectal fistula (HP:0100590)2.92967983
52Amyotrophic lateral sclerosis (HP:0007354)2.92903177
53Joint hemorrhage (HP:0005261)2.90322870
54Aplasia of the musculature (HP:0100854)2.89789580
55Anteriorly placed anus (HP:0001545)2.89388762
56Bifid tongue (HP:0010297)2.88045097
57Partial duplication of thumb phalanx (HP:0009944)2.87870701
58Fetal akinesia sequence (HP:0001989)2.87244565
59Patellar aplasia (HP:0006443)2.83209524
60Generalized hypotonia (HP:0001290)2.79322165
61Abnormality of the pulmonary veins (HP:0011718)2.78212440
62Abnormal cartilage morphology (HP:0002763)2.76650014
63Capillary hemangiomas (HP:0005306)2.76598653
64Increased connective tissue (HP:0009025)2.74132693
65Abnormality of the fovea (HP:0000493)2.73263298
66Tetraplegia (HP:0002445)2.72998246
67Narrow nasal bridge (HP:0000446)2.68105575
68Mesangial abnormality (HP:0001966)2.67687047
69Amblyopia (HP:0000646)2.67136689
70Intestinal fistula (HP:0100819)2.65162859
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.63258533
72Neonatal respiratory distress (HP:0002643)2.61944112
73Preauricular pit (HP:0004467)2.58554585
74Periauricular skin pits (HP:0100277)2.58554585
75Preauricular skin tag (HP:0000384)2.58251999
76Absent septum pellucidum (HP:0001331)2.58014899
77Aplasia/Hypoplasia of the patella (HP:0006498)2.56251066
78Abnormality of the costochondral junction (HP:0000919)2.55730942
79Hypochromic anemia (HP:0001931)2.55184178
80Abnormality of placental membranes (HP:0011409)2.54305332
81Amniotic constriction ring (HP:0009775)2.54305332
82Trismus (HP:0000211)2.52724374
83Vaginal fistula (HP:0004320)2.50982307
84Difficulty running (HP:0009046)2.50242171
85Short humerus (HP:0005792)2.48897296
86Partial duplication of the phalanx of hand (HP:0009999)2.48160592
87Atrioventricular block (HP:0001678)2.47575315
88Aplasia/hypoplasia of the humerus (HP:0006507)2.47220899
89Neoplasm of the heart (HP:0100544)2.46709614
90Widely patent fontanelles and sutures (HP:0004492)2.46409901
91Neonatal onset (HP:0003623)2.45859813
92Tongue fasciculations (HP:0001308)2.44927208
93Renal Fanconi syndrome (HP:0001994)2.44740968
94Flat occiput (HP:0005469)2.44618918
95Nasolacrimal duct obstruction (HP:0000579)2.43852690
96Rickets (HP:0002748)2.43262299
97Shawl scrotum (HP:0000049)2.41632087
98Large earlobe (HP:0009748)2.40307683
99Hemorrhage of the eye (HP:0011885)2.39229026
100Abnormality of chromosome segregation (HP:0002916)2.39058544
101Reduced antithrombin III activity (HP:0001976)2.36873914
102Increased number of teeth (HP:0011069)2.34563665
103Abnormality of the hepatic vasculature (HP:0006707)2.33982443
104Short 5th finger (HP:0009237)2.33388656
105Aplasia/Hypoplasia of the macula (HP:0008059)2.33224514
106Abnormal albumin level (HP:0012116)2.33011055
107Hypoalbuminemia (HP:0003073)2.33011055
108Renal duplication (HP:0000075)2.30982986
109Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30576764
110Skin tags (HP:0010609)2.28238655
111Mildly elevated creatine phosphokinase (HP:0008180)2.26724450
112Muscle fibrillation (HP:0010546)2.25965725
113Abnormality of the common coagulation pathway (HP:0010990)2.24250466
114Upper limb muscle weakness (HP:0003484)2.24110841
115Progressive muscle weakness (HP:0003323)2.23837778
116Supernumerary nipples (HP:0002558)2.23739013
117Abnormal lung lobation (HP:0002101)2.22978736
118Choroideremia (HP:0001139)2.21633796
119Dyschromatopsia (HP:0007641)2.21565756
120Resting tremor (HP:0002322)2.21414241
121Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20235236
122Polydipsia (HP:0001959)2.19629785
123Abnormal drinking behavior (HP:0030082)2.19629785
124Glioma (HP:0009733)2.16470626
125Abnormality of small intestinal villus morphology (HP:0011472)2.16318603
126Villous atrophy (HP:0011473)2.16318603
127Progressive external ophthalmoplegia (HP:0000590)2.15974470
128Malignant neoplasm of the central nervous system (HP:0100836)2.15723071
129Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.15700883
130Maternal diabetes (HP:0009800)2.14541163
131* Horizontal nystagmus (HP:0000666)2.12978277
132Ketoacidosis (HP:0001993)2.12785002
133Skin nodule (HP:0200036)2.12640066
134Aplasia/Hypoplasia affecting the retina (HP:0008061)2.12478131
135Absent thumb (HP:0009777)2.12379330
136Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11502863
137Zonular cataract (HP:0010920)2.10594248
138Abnormality of the pubic bones (HP:0003172)2.06987941
139Male infertility (HP:0003251)2.06820146
140Malnutrition (HP:0004395)2.06449454
141Upper motor neuron abnormality (HP:0002127)2.06132792
142Hemiparesis (HP:0001269)2.04647247
143Premature graying of hair (HP:0002216)2.04322131
144Abnormality of the phalanges of the hallux (HP:0010057)2.03160395
145Generalized aminoaciduria (HP:0002909)2.02766660
146Joint stiffness (HP:0001387)2.02532304
147Pseudobulbar signs (HP:0002200)2.01696498
148Supernumerary spleens (HP:0009799)2.01093260
149Ankle clonus (HP:0011448)1.99929479
150Hypopigmentation of the fundus (HP:0007894)1.98765110
151Papilledema (HP:0001085)1.98429406
152Metaphyseal irregularity (HP:0003025)1.97411714
153Supernumerary ribs (HP:0005815)1.97291874
154Impulsivity (HP:0100710)1.97133615
155Abnormal urine phosphate concentration (HP:0012599)1.97117137
156Skin pits (HP:0100276)1.96892358
157Glossoptosis (HP:0000162)1.96665784
158Abnormal epiphyseal ossification (HP:0010656)1.96229323
159Microvesicular hepatic steatosis (HP:0001414)1.95475869
1603-Methylglutaconic aciduria (HP:0003535)1.95166262
161Abnormality of the intrinsic pathway (HP:0010989)1.93397576
162Abnormality of the distal phalanx of the thumb (HP:0009617)1.93334123
163Abnormality of the musculature of the hand (HP:0001421)1.91503007
164Abnormal biliary tract physiology (HP:0012439)1.91409100
165Bile duct proliferation (HP:0001408)1.91409100
166Lipid accumulation in hepatocytes (HP:0006561)1.90841129
167Poor head control (HP:0002421)1.89424654
168Achilles tendon contracture (HP:0001771)1.88593018
169Hypobetalipoproteinemia (HP:0003563)1.88156213
170Nasal polyposis (HP:0100582)1.87256392
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87253177
172Embryonal neoplasm (HP:0002898)1.86555866
173Webbed neck (HP:0000465)1.86285624
174Dyskinesia (HP:0100660)1.86017555
175Myotonia (HP:0002486)1.85997678
176Abnormality of the septum pellucidum (HP:0007375)1.83840482
177Decreased central vision (HP:0007663)1.82787036
178Optic nerve hypoplasia (HP:0000609)1.81475160
179Polyuria (HP:0000103)1.79826184
180Increased hepatocellular lipid droplets (HP:0006565)1.78105630
181Stomatitis (HP:0010280)1.77898034
182Elevated alkaline phosphatase (HP:0003155)1.77101743
183Malignant hyperthermia (HP:0002047)1.76107627
184Breast aplasia (HP:0100783)1.73174087
185Cystic hygroma (HP:0000476)1.70646780
186Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70321609
187Methylmalonic aciduria (HP:0012120)1.69990586
188Abnormal protein N-linked glycosylation (HP:0012347)1.68027697
189Abnormal protein glycosylation (HP:0012346)1.68027697
190Abnormal glycosylation (HP:0012345)1.68027697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.69075772
2MAPK155.79045573
3GRK55.67673737
4IRAK35.55348729
5ERN14.76113601
6GRK64.26819467
7MUSK3.55427572
8WNK43.33697337
9ADRBK23.24600197
10BLK3.17967626
11GRK13.08066963
12MATK2.96767975
13TYRO32.95551633
14BMPR22.88470591
15TGFBR22.85250971
16NTRK12.70668326
17CSF1R2.67047412
18GRK72.56594842
19MAPK72.51977568
20MAP2K42.18592518
21MOS2.06393334
22WNK12.03993203
23PKN21.99032840
24TTK1.97535487
25IKBKE1.80080537
26FRK1.79721688
27TBK11.73264942
28STK101.72339215
29IKBKB1.68349978
30IRAK21.62285189
31ACVR1B1.59262486
32TLK11.57525162
33MAP3K141.56697195
34CAMK41.53595260
35MARK21.46578547
36ERBB31.45425316
37CHUK1.42023469
38TAOK11.34836426
39ADRBK11.27771962
40TESK21.23186280
41STK38L1.22975325
42PRKG21.22818163
43CSNK1A1L1.14169499
44FGFR31.08184315
45CDK71.08094734
46DYRK31.05282372
47ZAP701.03856585
48HIPK21.03829896
49EPHA21.02210008
50MARK31.01140928
51ZAK0.99770888
52MAP3K120.99187156
53CLK10.98457813
54AKT30.96965213
55MAP3K110.96522644
56CSNK1G30.95956980
57MAP2K60.94918939
58PAK40.94844417
59MAP3K70.93722115
60CSNK1G20.92926976
61FGR0.92453752
62PIM20.91128951
63DYRK1B0.90460654
64PDGFRA0.90051911
65MAPK120.88062004
66YES10.87112872
67CDK40.86843942
68CSK0.86310093
69DYRK20.84859013
70MAP3K90.83043792
71WNK30.80254517
72NTRK30.78714769
73OXSR10.78187009
74LATS20.76802005
75CHEK20.76414964
76TAOK20.76184190
77PKN10.75396754
78CSNK1D0.74018246
79MAPK130.72137514
80STK160.71520366
81TXK0.71428966
82MAP3K100.71163499
83CCNB10.69952025
84IRAK40.69438416
85ALK0.68652739
86CDK60.67678524
87TAOK30.66079276
88RIPK10.63271722
89AKT20.61058604
90NTRK20.60918537
91MAP3K30.60286853
92CSNK1G10.59576965
93PDPK10.58532056
94MAP2K30.58308454
95SIK20.57133697
96PLK10.55992662
97SGK2230.55828167
98SGK4940.55828167
99SIK10.53726186
100ERBB20.53183906
101PDK20.52137052
102ITK0.50301924
103PRPF4B0.50029733
104CASK0.49870968
105IGF1R0.49584476
106RPS6KA60.48705913
107LYN0.47196412
108FLT30.46869606
109RPS6KA20.46798693
110STK390.45089162
111DDR20.43643257
112TRIM280.43614077
113CHEK10.43477238
114CDC42BPA0.42923581
115ATR0.42899367
116PRKCG0.42709126
117MAP3K40.41232355
118MAPK110.40423555
119EPHA40.37825628
120PRKD10.36813812
121PTK20.36500249
122MAPK100.36437438
123RPS6KC10.35929721
124RPS6KL10.35929721
125EIF2AK20.35728776
126STK380.33630692
127MARK10.33591001
128RPS6KA40.33574400
129PIM10.33507795
130BMPR1B0.33161317
131MTOR0.32472860
132BMX0.31688045
133EPHA30.29936465
134LATS10.29777648
135PRKD20.29000567
136PRKCD0.28975666
137IRAK10.28479820
138PAK60.28049593
139CDK20.27391250
140DYRK1A0.27322549
141INSR0.26083064
142GSK3A0.26063096
143PRKACG0.26042318
144MAPK40.25637150
145CSNK1E0.24582977
146PRKCI0.23927846
147SCYL20.23803398
148PAK30.22227831
149PRKACB0.22160789
150DAPK20.21621832
151PRKACA0.20801271
152GSK3B0.20743201
153RPS6KA30.20076671
154CDK150.19799933
155CDK180.18239362
156PRKCH0.16499291
157CDK11A0.15349308
158MAPK10.14711321
159PRKAA10.13896127
160SRC0.13848398
161PAK10.13225815
162PHKG20.12828368
163PHKG10.12828368
164CAMK10.12440180
165MAPK140.12342856
166CDK10.12253674
167MAPK80.12243746
168SIK30.12226659
169CDK140.11192079
170AURKA0.11068676
171CDK50.10923623
172MAP2K70.10038645
173ATM0.10023558

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.66656072
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006036.30271077
3Sulfur relay system_Homo sapiens_hsa041224.83679199
4Fructose and mannose metabolism_Homo sapiens_hsa000513.77937261
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.32057230
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.99630476
7Nicotine addiction_Homo sapiens_hsa050332.75837352
8Arachidonic acid metabolism_Homo sapiens_hsa005902.52045923
9Linoleic acid metabolism_Homo sapiens_hsa005912.46879656
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40167577
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.38693617
12Galactose metabolism_Homo sapiens_hsa000522.30356976
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19744123
14Pertussis_Homo sapiens_hsa051332.09127370
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.00525227
16Thyroid cancer_Homo sapiens_hsa052161.90311291
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86880875
18Sphingolipid metabolism_Homo sapiens_hsa006001.70537506
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.69504563
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69153421
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67120494
22mTOR signaling pathway_Homo sapiens_hsa041501.65927892
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57172126
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.52187878
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.50970483
26Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.49143376
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49049680
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.46873613
29Phospholipase D signaling pathway_Homo sapiens_hsa040721.43826232
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.43698453
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.39704119
32Prion diseases_Homo sapiens_hsa050201.39115721
33Rheumatoid arthritis_Homo sapiens_hsa053231.38611320
34TNF signaling pathway_Homo sapiens_hsa046681.37286729
35Graft-versus-host disease_Homo sapiens_hsa053321.36275797
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36264318
37Glutamatergic synapse_Homo sapiens_hsa047241.34512979
38Salmonella infection_Homo sapiens_hsa051321.34247793
39Legionellosis_Homo sapiens_hsa051341.32784179
40Ovarian steroidogenesis_Homo sapiens_hsa049131.19375013
41GABAergic synapse_Homo sapiens_hsa047271.19366955
42Ether lipid metabolism_Homo sapiens_hsa005651.17030640
43Fatty acid biosynthesis_Homo sapiens_hsa000611.16832200
44Taste transduction_Homo sapiens_hsa047421.16800080
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16472570
46Serotonergic synapse_Homo sapiens_hsa047261.15522346
47Inositol phosphate metabolism_Homo sapiens_hsa005621.10056116
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09971988
49Malaria_Homo sapiens_hsa051441.09603195
50Choline metabolism in cancer_Homo sapiens_hsa052311.09506388
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09222505
52Leishmaniasis_Homo sapiens_hsa051401.07267241
53Morphine addiction_Homo sapiens_hsa050321.06363185
54Long-term depression_Homo sapiens_hsa047301.06155773
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05051813
56GnRH signaling pathway_Homo sapiens_hsa049121.04518007
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03820497
58Regulation of actin cytoskeleton_Homo sapiens_hsa048101.01738287
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.97096069
60Rap1 signaling pathway_Homo sapiens_hsa040150.97079181
61Osteoclast differentiation_Homo sapiens_hsa043800.96419459
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94245538
63Type I diabetes mellitus_Homo sapiens_hsa049400.94216095
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94173028
65Tuberculosis_Homo sapiens_hsa051520.93305243
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91754765
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.90870916
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87565480
69Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.87514780
70Lysosome_Homo sapiens_hsa041420.85364036
71Hematopoietic cell lineage_Homo sapiens_hsa046400.83935839
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.83867723
73Long-term potentiation_Homo sapiens_hsa047200.82544337
74Pathways in cancer_Homo sapiens_hsa052000.81959794
75PPAR signaling pathway_Homo sapiens_hsa033200.81344534
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.80768283
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79319357
78Dilated cardiomyopathy_Homo sapiens_hsa054140.78581281
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78512442
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78207007
81Circadian rhythm_Homo sapiens_hsa047100.78013400
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77502413
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76401814
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75987843
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75188530
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73899913
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73711062
88Influenza A_Homo sapiens_hsa051640.73355472
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73336799
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.72820182
91Bladder cancer_Homo sapiens_hsa052190.72479484
92Dorso-ventral axis formation_Homo sapiens_hsa043200.72364428
93Non-small cell lung cancer_Homo sapiens_hsa052230.71683520
94Calcium signaling pathway_Homo sapiens_hsa040200.70899592
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.70581571
96Chemical carcinogenesis_Homo sapiens_hsa052040.70377132
97African trypanosomiasis_Homo sapiens_hsa051430.69841755
98Ras signaling pathway_Homo sapiens_hsa040140.69425848
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67608442
100VEGF signaling pathway_Homo sapiens_hsa043700.64087532
101MicroRNAs in cancer_Homo sapiens_hsa052060.63562701
102Oxytocin signaling pathway_Homo sapiens_hsa049210.63444976
103cAMP signaling pathway_Homo sapiens_hsa040240.61749011
104Cocaine addiction_Homo sapiens_hsa050300.60009181
105Acute myeloid leukemia_Homo sapiens_hsa052210.59481696
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59254634
107Phenylalanine metabolism_Homo sapiens_hsa003600.58815746
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58584226
109Basal cell carcinoma_Homo sapiens_hsa052170.58312737
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.58180383
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57335317
112Other glycan degradation_Homo sapiens_hsa005110.55182938
113Fanconi anemia pathway_Homo sapiens_hsa034600.54823100
114Proteoglycans in cancer_Homo sapiens_hsa052050.53975202
115Fatty acid degradation_Homo sapiens_hsa000710.53787880
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.53414243
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53144072
118Protein digestion and absorption_Homo sapiens_hsa049740.52958582
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51857795
120Glycerolipid metabolism_Homo sapiens_hsa005610.51214124
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.50695214
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50430964
123mRNA surveillance pathway_Homo sapiens_hsa030150.49929089
124Hedgehog signaling pathway_Homo sapiens_hsa043400.48692979
125Tight junction_Homo sapiens_hsa045300.48215416
126MAPK signaling pathway_Homo sapiens_hsa040100.45431078
127Wnt signaling pathway_Homo sapiens_hsa043100.45302598
128ErbB signaling pathway_Homo sapiens_hsa040120.45274322
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.44665254
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44653940
131Caffeine metabolism_Homo sapiens_hsa002320.44352012
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44204865
133Staphylococcus aureus infection_Homo sapiens_hsa051500.42835948
134Salivary secretion_Homo sapiens_hsa049700.42044549
135Complement and coagulation cascades_Homo sapiens_hsa046100.41466304
136Renin secretion_Homo sapiens_hsa049240.41113239
137Pancreatic cancer_Homo sapiens_hsa052120.40803789
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.39908057
139Retinol metabolism_Homo sapiens_hsa008300.39766479
140Vitamin digestion and absorption_Homo sapiens_hsa049770.39509570
141Axon guidance_Homo sapiens_hsa043600.39424127
142Hippo signaling pathway_Homo sapiens_hsa043900.38889769
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.38843628
144Bile secretion_Homo sapiens_hsa049760.38765142
145Hepatitis C_Homo sapiens_hsa051600.38313344
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37933119
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37113837
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36818404
149Measles_Homo sapiens_hsa051620.36060478
150AMPK signaling pathway_Homo sapiens_hsa041520.35426690
151Sulfur metabolism_Homo sapiens_hsa009200.34407730
152Sphingolipid signaling pathway_Homo sapiens_hsa040710.34125738
153Colorectal cancer_Homo sapiens_hsa052100.33794404
154Tryptophan metabolism_Homo sapiens_hsa003800.32030912
155Glioma_Homo sapiens_hsa052140.31139496
156Gap junction_Homo sapiens_hsa045400.29937881
157Circadian entrainment_Homo sapiens_hsa047130.29898749
158Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28841126
159Adipocytokine signaling pathway_Homo sapiens_hsa049200.28624399
160Pentose phosphate pathway_Homo sapiens_hsa000300.28188508
161Asthma_Homo sapiens_hsa053100.27955945
162Dopaminergic synapse_Homo sapiens_hsa047280.27942818
163Toxoplasmosis_Homo sapiens_hsa051450.27878866
164Focal adhesion_Homo sapiens_hsa045100.27218056
165Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26942692
166Cardiac muscle contraction_Homo sapiens_hsa042600.26769358
167Fatty acid metabolism_Homo sapiens_hsa012120.26423290
168Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.24761811
169Hepatitis B_Homo sapiens_hsa051610.24665350
170Prolactin signaling pathway_Homo sapiens_hsa049170.23114831
171Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21999440
172Chemokine signaling pathway_Homo sapiens_hsa040620.21560179
173Type II diabetes mellitus_Homo sapiens_hsa049300.21106722
174N-Glycan biosynthesis_Homo sapiens_hsa005100.20718224
175Arginine biosynthesis_Homo sapiens_hsa002200.18227849
176Insulin resistance_Homo sapiens_hsa049310.18082803
177Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17487447

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