FRG2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of meiosis (GO:0045836)6.72327907
2oocyte development (GO:0048599)6.33159818
3positive regulation of meiotic cell cycle (GO:0051446)6.32315316
4multicellular organism reproduction (GO:0032504)5.71168647
5synaptonemal complex organization (GO:0070193)5.65077744
6negative regulation of Ras GTPase activity (GO:0034261)5.49134106
7histone lysine demethylation (GO:0070076)5.37632840
8synaptonemal complex assembly (GO:0007130)5.35005529
9gonadal mesoderm development (GO:0007506)5.27292304
10histone demethylation (GO:0016577)5.13816437
11regulation of alternative mRNA splicing, via spliceosome (GO:0000381)5.11853970
12regulation of acrosome reaction (GO:0060046)4.93771852
13regulation of RIG-I signaling pathway (GO:0039535)4.91985809
14regulation of exit from mitosis (GO:0007096)4.79879131
15protein dealkylation (GO:0008214)4.70153631
16protein demethylation (GO:0006482)4.70153631
17regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.58379500
18positive regulation of catecholamine secretion (GO:0033605)4.56337540
19acrosome reaction (GO:0007340)4.49632115
20positive regulation of uterine smooth muscle contraction (GO:0070474)4.39603615
21piRNA metabolic process (GO:0034587)4.35414156
22single fertilization (GO:0007338)4.29656303
23male meiosis (GO:0007140)4.29231298
24epithelial cilium movement (GO:0003351)4.25589757
25regulation of female receptivity (GO:0045924)3.98839407
26male meiosis I (GO:0007141)3.97917799
27cilium movement (GO:0003341)3.87773193
28protein K48-linked deubiquitination (GO:0071108)3.81543092
29centriole replication (GO:0007099)3.78628374
30N-terminal protein amino acid acetylation (GO:0006474)3.75411583
31tryptophan catabolic process (GO:0006569)3.75317973
32indole-containing compound catabolic process (GO:0042436)3.75317973
33indolalkylamine catabolic process (GO:0046218)3.75317973
34indolalkylamine metabolic process (GO:0006586)3.73567778
35chromosome organization involved in meiosis (GO:0070192)3.65340198
36kynurenine metabolic process (GO:0070189)3.62279766
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60950422
38reproduction (GO:0000003)3.57758531
39aggressive behavior (GO:0002118)3.48092332
40regulation of meiosis (GO:0040020)3.46020581
41regulation of uterine smooth muscle contraction (GO:0070472)3.43064628
42behavioral response to nicotine (GO:0035095)3.42750359
43female mating behavior (GO:0060180)3.32640213
44peristalsis (GO:0030432)3.28135324
45regulation of defense response to virus by host (GO:0050691)3.26621602
46tryptophan metabolic process (GO:0006568)3.21571164
47fertilization (GO:0009566)3.20142195
48DNA methylation involved in gamete generation (GO:0043046)3.14075297
49protein K63-linked deubiquitination (GO:0070536)3.13954163
50calcium ion-dependent exocytosis (GO:0017156)3.12603692
51mitochondrial respiratory chain complex assembly (GO:0033108)3.10585251
52positive regulation of histone H3-K4 methylation (GO:0051571)3.09052483
53meiosis I (GO:0007127)3.07950090
54regulation of cytokine production involved in inflammatory response (GO:1900015)3.04746089
55regulation of penile erection (GO:0060405)3.01055491
56regulation of ruffle assembly (GO:1900027)2.98848351
57regulation of mRNA splicing, via spliceosome (GO:0048024)2.98557875
58meiotic cell cycle (GO:0051321)2.96600269
59binding of sperm to zona pellucida (GO:0007339)2.94130280
60positive regulation of digestive system process (GO:0060456)2.92183709
61cochlea development (GO:0090102)2.91428147
62regulation of helicase activity (GO:0051095)2.91374843
63postsynaptic membrane organization (GO:0001941)2.88455970
64demethylation (GO:0070988)2.87717354
65gamma-aminobutyric acid signaling pathway (GO:0007214)2.87456617
66neurofilament cytoskeleton organization (GO:0060052)2.86603177
67spermatid development (GO:0007286)2.85910639
68indole-containing compound metabolic process (GO:0042430)2.82919071
69NAD biosynthetic process (GO:0009435)2.82050760
70regulation of meiotic cell cycle (GO:0051445)2.81945943
71regulation of neurotransmitter uptake (GO:0051580)2.80930803
72sperm-egg recognition (GO:0035036)2.80018174
73phasic smooth muscle contraction (GO:0014821)2.79797894
74exocrine pancreas development (GO:0031017)2.76465283
75regulation of DNA endoreduplication (GO:0032875)2.76059402
76maternal behavior (GO:0042711)2.75447166
77positive regulation of prostaglandin secretion (GO:0032308)2.74033445
78protein K6-linked ubiquitination (GO:0085020)2.73046737
79ventricular system development (GO:0021591)2.72054156
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71488202
81negative regulation of digestive system process (GO:0060457)2.70271425
82sleep (GO:0030431)2.69900741
83pancreas development (GO:0031016)2.69864723
84cellular anion homeostasis (GO:0030002)2.69782617
85vitamin catabolic process (GO:0009111)2.68920111
86fat-soluble vitamin catabolic process (GO:0042363)2.68920111
87positive regulation of amine transport (GO:0051954)2.68031906
88negative regulation of smooth muscle cell differentiation (GO:0051151)2.67672580
89negative regulation of reproductive process (GO:2000242)2.66691167
90protein complex biogenesis (GO:0070271)2.66225029
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65776605
92mitochondrial respiratory chain complex I assembly (GO:0032981)2.65776605
93NADH dehydrogenase complex assembly (GO:0010257)2.65776605
94photoreceptor cell maintenance (GO:0045494)2.65647941
95regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.63873053
96meiotic cell cycle process (GO:1903046)2.62900227
97hindbrain development (GO:0030902)2.61392398
98response to UV-C (GO:0010225)2.60605446
99RNA localization (GO:0006403)2.60205540
100histone H3-K9 demethylation (GO:0033169)14.5270994

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.17731565
2EZH2_22144423_ChIP-Seq_EOC_Human5.54647731
3VDR_22108803_ChIP-Seq_LS180_Human3.47397421
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45852065
5GBX2_23144817_ChIP-Seq_PC3_Human3.15374586
6IGF1R_20145208_ChIP-Seq_DFB_Human2.76183891
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70061079
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59667634
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57013671
10ZNF274_21170338_ChIP-Seq_K562_Hela2.53915907
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.52831207
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.23881233
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.13836220
14BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13316728
15P300_19829295_ChIP-Seq_ESCs_Human2.08074976
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.99410047
17RNF2_27304074_Chip-Seq_NSC_Mouse1.95589337
18TAF15_26573619_Chip-Seq_HEK293_Human1.93446143
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85805947
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.84808306
21* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.82597881
22SMAD4_21799915_ChIP-Seq_A2780_Human1.79665259
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.79209339
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.78633777
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.74425300
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74254203
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70971870
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70581864
29POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67760631
30MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.67144353
31IRF1_19129219_ChIP-ChIP_H3396_Human1.66410743
32PRDM14_20953172_ChIP-Seq_ESCs_Human1.64799475
33* TCF4_23295773_ChIP-Seq_U87_Human1.64256464
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64231803
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63389089
36AR_25329375_ChIP-Seq_VCAP_Human1.63172363
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62665134
38JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62339057
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58456595
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.56548756
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55453407
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55283967
43BCAT_22108803_ChIP-Seq_LS180_Human1.54949490
44* STAT3_23295773_ChIP-Seq_U87_Human1.53820686
45FUS_26573619_Chip-Seq_HEK293_Human1.52669168
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52502507
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.51444459
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49981107
49EWS_26573619_Chip-Seq_HEK293_Human1.44290009
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42635428
51MYC_18940864_ChIP-ChIP_HL60_Human1.42339552
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41747166
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.38807433
54SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.38238286
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.37363954
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.36691803
57SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35945048
58RUNX2_22187159_ChIP-Seq_PCA_Human1.35882638
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35851508
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35095208
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31915219
62CBP_21632823_ChIP-Seq_H3396_Human1.30536553
63* TCF4_22108803_ChIP-Seq_LS180_Human1.28760070
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27687824
65REST_21632747_ChIP-Seq_MESCs_Mouse1.22008394
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21487532
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.20112684
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19963958
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19132170
70CBP_20019798_ChIP-Seq_JUKART_Human1.18643865
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18643865
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.17103314
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.16429673
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15450524
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14426854
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13633187
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.12632519
78TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12530475
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.12000889
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11627847
81ER_23166858_ChIP-Seq_MCF-7_Human1.10295892
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06792693
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05443306
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05443306
85* NCOR_22424771_ChIP-Seq_293T_Human1.05309415
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04842739
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04579445
88* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03438450
89TP53_20018659_ChIP-ChIP_R1E_Mouse1.02663325
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01539369
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00796326
92SOX2_19829295_ChIP-Seq_ESCs_Human1.00162574
93NANOG_19829295_ChIP-Seq_ESCs_Human1.00162574
94AR_21572438_ChIP-Seq_LNCaP_Human0.98636952
95SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98496100
96TAL1_26923725_Chip-Seq_HPCs_Mouse0.96135142
97FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95928944
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.95885498
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92601732
100* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.91750824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.44441363
2MP0003283_abnormal_digestive_organ3.63304053
3MP0003136_yellow_coat_color3.27855663
4MP0000427_abnormal_hair_cycle2.88393038
5MP0002160_abnormal_reproductive_system2.86944222
6MP0006276_abnormal_autonomic_nervous2.73696379
7MP0009379_abnormal_foot_pigmentation2.55302856
8MP0003950_abnormal_plasma_membrane2.55062877
9MP0005410_abnormal_fertilization2.40171471
10MP0000678_abnormal_parathyroid_gland2.24410309
11MP0008058_abnormal_DNA_repair2.16784230
12MP0002102_abnormal_ear_morphology2.11738569
13MP0001502_abnormal_circadian_rhythm2.09185205
14MP0005646_abnormal_pituitary_gland2.07732705
15MP0003693_abnormal_embryo_hatching2.07018665
16MP0000569_abnormal_digit_pigmentation2.06815258
17MP0008877_abnormal_DNA_methylation2.02364983
18MP0001929_abnormal_gametogenesis1.95023378
19MP0003119_abnormal_digestive_system1.91593645
20MP0004043_abnormal_pH_regulation1.87758101
21MP0006072_abnormal_retinal_apoptosis1.87324389
22MP0005220_abnormal_exocrine_pancreas1.84181405
23MP0002751_abnormal_autonomic_nervous1.84083479
24MP0001664_abnormal_digestion1.83342932
25MP0002163_abnormal_gland_morphology1.80207990
26MP0002210_abnormal_sex_determination1.65097847
27MP0005389_reproductive_system_phenotype1.58181934
28MP0000631_abnormal_neuroendocrine_gland1.57890329
29MP0000049_abnormal_middle_ear1.49642252
30MP0002272_abnormal_nervous_system1.49285753
31MP0009745_abnormal_behavioral_response1.48222591
32MP0005551_abnormal_eye_electrophysiolog1.47457224
33MP0003183_abnormal_peptide_metabolism1.41776450
34MP0003718_maternal_effect1.38282356
35MP0003698_abnormal_male_reproductive1.38065171
36MP0000778_abnormal_nervous_system1.36836346
37MP0003890_abnormal_embryonic-extraembry1.35631089
38MP0001486_abnormal_startle_reflex1.34207755
39MP0000653_abnormal_sex_gland1.31038995
40MP0004742_abnormal_vestibular_system1.30176432
41MP0001968_abnormal_touch/_nociception1.29356543
42MP0009046_muscle_twitch1.28934244
43MP0002277_abnormal_respiratory_mucosa1.27615284
44MP0003699_abnormal_female_reproductive1.26512294
45MP0002184_abnormal_innervation1.23352419
46MP0000230_abnormal_systemic_arterial1.22188504
47MP0002837_dystrophic_cardiac_calcinosis1.21781855
48MP0001666_abnormal_nutrient_absorption1.21076709
49MP0002735_abnormal_chemical_nociception1.19399513
50MP0005360_urolithiasis1.18767213
51MP0005394_taste/olfaction_phenotype1.16418645
52MP0005499_abnormal_olfactory_system1.16418645
53MP0001501_abnormal_sleep_pattern1.16157600
54MP0004142_abnormal_muscle_tone1.15325817
55MP0000372_irregular_coat_pigmentation1.14077233
56MP0005084_abnormal_gallbladder_morpholo1.12548427
57MP0005253_abnormal_eye_physiology1.12479261
58MP0001485_abnormal_pinna_reflex1.12051393
59MP0001145_abnormal_male_reproductive1.09561280
60MP0001440_abnormal_grooming_behavior1.06155006
61MP0003868_abnormal_feces_composition1.04158854
62MP0000647_abnormal_sebaceous_gland1.03340557
63MP0001119_abnormal_female_reproductive1.03304820
64MP0008872_abnormal_physiological_respon1.02323116
65MP0002161_abnormal_fertility/fecundity0.99736960
66MP0005645_abnormal_hypothalamus_physiol0.99018674
67MP0002736_abnormal_nociception_after0.98934878
68MP0002557_abnormal_social/conspecific_i0.98490938
69MP0002229_neurodegeneration0.98407131
70MP0003866_abnormal_defecation0.98280766
71MP0002067_abnormal_sensory_capabilities0.95980595
72MP0009384_cardiac_valve_regurgitation0.94341071
73MP0002734_abnormal_mechanical_nocicepti0.94156089
74MP0003936_abnormal_reproductive_system0.93977053
75MP0003121_genomic_imprinting0.93717424
76MP0003880_abnormal_central_pattern0.92974365
77MP0001286_abnormal_eye_development0.91490748
78MP0003195_calcinosis0.91459766
79MP0001963_abnormal_hearing_physiology0.89355309
80MP0003635_abnormal_synaptic_transmissio0.88301043
81MP0005647_abnormal_sex_gland0.88212669
82MP0000470_abnormal_stomach_morphology0.87629949
83MP0005379_endocrine/exocrine_gland_phen0.86256211
84MP0004270_analgesia0.85868070
85MP0000026_abnormal_inner_ear0.84701733
86MP0003938_abnormal_ear_development0.83337692
87MP0002752_abnormal_somatic_nervous0.81343678
88MP0010094_abnormal_chromosome_stability0.80963169
89MP0002064_seizures0.79930558
90MP0002693_abnormal_pancreas_physiology0.79074676
91MP0008789_abnormal_olfactory_epithelium0.78890972
92MP0005670_abnormal_white_adipose0.78507105
93MP0001944_abnormal_pancreas_morphology0.77446463
94MP0002090_abnormal_vision0.76967892
95MP0003937_abnormal_limbs/digits/tail_de0.75586260
96MP0002095_abnormal_skin_pigmentation0.72789758
97MP0001764_abnormal_homeostasis0.72363927
98MP0002572_abnormal_emotion/affect_behav0.71855446
99MP0009840_abnormal_foam_cell0.71446834
100MP0005195_abnormal_posterior_eye0.71264443

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)4.51571449
2Aplasia/Hypoplasia of the tibia (HP:0005772)4.14621029
3Short tibia (HP:0005736)4.10568464
4Median cleft lip (HP:0000161)4.07781410
5Oligodactyly (hands) (HP:0001180)3.95347927
6Pancreatic fibrosis (HP:0100732)3.90284729
7Atonic seizures (HP:0010819)3.81425656
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.37685263
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.37685263
10Amelogenesis imperfecta (HP:0000705)3.21538315
11Abnormal ciliary motility (HP:0012262)2.94139600
12Congenital sensorineural hearing impairment (HP:0008527)2.93912179
13Abnormality of the nasal septum (HP:0000419)2.93282480
14Medial flaring of the eyebrow (HP:0010747)2.90096752
15Adrenal hypoplasia (HP:0000835)2.89441116
16Tetany (HP:0001281)2.80107504
17Absent/shortened dynein arms (HP:0200106)2.76405561
18Dynein arm defect of respiratory motile cilia (HP:0012255)2.76405561
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76011408
20Genital tract atresia (HP:0001827)2.73530654
21Aplasia/Hypoplasia of the tongue (HP:0010295)2.72690479
22True hermaphroditism (HP:0010459)2.71729669
23Oligodactyly (HP:0012165)2.70750163
24Abnormality of the corticospinal tract (HP:0002492)2.67440345
25Impulsivity (HP:0100710)2.66336031
26Gait imbalance (HP:0002141)2.61812504
27Abnormality of the renal cortex (HP:0011035)2.60407410
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59701999
29Abnormality of alanine metabolism (HP:0010916)2.59701999
30Hyperalaninemia (HP:0003348)2.59701999
31Abnormality of the labia minora (HP:0012880)2.59222583
32Molar tooth sign on MRI (HP:0002419)2.58450492
33Abnormality of midbrain morphology (HP:0002418)2.58450492
34Microglossia (HP:0000171)2.51519297
35Congenital primary aphakia (HP:0007707)2.50216653
36Abnormal respiratory motile cilium physiology (HP:0012261)2.49232420
37Increased hepatocellular lipid droplets (HP:0006565)2.49030125
38Hyperphosphatemia (HP:0002905)2.48011303
39Metaphyseal dysplasia (HP:0100255)2.47276809
40Concave nail (HP:0001598)2.43316757
41Pancreatic cysts (HP:0001737)2.42678109
42Gaze-evoked nystagmus (HP:0000640)2.41070360
43Focal motor seizures (HP:0011153)2.40044037
44Abnormality of dental color (HP:0011073)2.39799307
45Abnormal number of incisors (HP:0011064)2.39119842
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.37324810
47Ectopic kidney (HP:0000086)2.31978544
48Abnormality of abdominal situs (HP:0011620)2.28046896
49Abdominal situs inversus (HP:0003363)2.28046896
50Abnormal auditory evoked potentials (HP:0006958)2.23004922
51Exertional dyspnea (HP:0002875)2.22022945
52Nephrogenic diabetes insipidus (HP:0009806)2.21664899
53Febrile seizures (HP:0002373)2.21424875
54Ulnar claw (HP:0001178)2.21236343
55Lipid accumulation in hepatocytes (HP:0006561)2.19580224
56Renal cortical cysts (HP:0000803)2.15955204
57Dialeptic seizures (HP:0011146)2.13965129
58Type I diabetes mellitus (HP:0100651)2.13251501
59Renal Fanconi syndrome (HP:0001994)2.12379473
60Facial cleft (HP:0002006)2.12120837
61Microretrognathia (HP:0000308)2.11756948
62Optic nerve hypoplasia (HP:0000609)2.11472524
63Mitochondrial inheritance (HP:0001427)2.07320888
64Abnormal respiratory motile cilium morphology (HP:0005938)2.07070966
65Abnormal respiratory epithelium morphology (HP:0012253)2.07070966
66Vaginal atresia (HP:0000148)2.06518466
67Postaxial foot polydactyly (HP:0001830)2.06495674
683-Methylglutaconic aciduria (HP:0003535)2.05600811
69Maternal diabetes (HP:0009800)2.02453590
70Increased CSF lactate (HP:0002490)2.01552775
71Mesangial abnormality (HP:0001966)2.00255208
72Abnormality of renal resorption (HP:0011038)1.99381239
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96417566
74Gastrointestinal atresia (HP:0002589)1.95954830
75Abolished electroretinogram (ERG) (HP:0000550)1.95918224
76Poor coordination (HP:0002370)1.94808906
77Myokymia (HP:0002411)1.93537270
78Pendular nystagmus (HP:0012043)1.93154540
79Disproportionate short-trunk short stature (HP:0003521)1.92881335
80Fair hair (HP:0002286)1.92855586
81Abnormality of the renal medulla (HP:0100957)1.92796016
82Bony spicule pigmentary retinopathy (HP:0007737)1.92615292
83Nephronophthisis (HP:0000090)1.91765069
84Rhinitis (HP:0012384)1.91361160
85Preaxial hand polydactyly (HP:0001177)1.90804066
86Absence seizures (HP:0002121)1.88201246
87Attenuation of retinal blood vessels (HP:0007843)1.85034693
88Acute necrotizing encephalopathy (HP:0006965)1.84013145
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.83415521
90Abnormality of chromosome stability (HP:0003220)1.82811747
91Short chin (HP:0000331)1.82746109
92Abnormality of calcium-phosphate metabolism (HP:0100530)1.81913731
93Colon cancer (HP:0003003)1.81439255
94Retinitis pigmentosa (HP:0000510)1.80649046
95Submucous cleft hard palate (HP:0000176)1.78203884
96Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78107654
97Absent thumb (HP:0009777)1.71581318
98Anterior segment dysgenesis (HP:0007700)1.68311448
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.67817699
100Sclerocornea (HP:0000647)1.67182555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.98889477
2TNIK3.82849693
3ZAK3.74938067
4TLK13.15590195
5INSRR3.11436973
6VRK12.75219838
7TAOK32.55227500
8MAP4K22.53273307
9PLK42.37807132
10BMPR1B2.34853862
11NUAK12.14513882
12STK392.06843548
13FRK2.03950638
14AURKA1.96391425
15ACVR1B1.95274625
16SRPK11.77593076
17WNK41.77331919
18CDK121.72689904
19CDK191.70414600
20TEC1.70253267
21WNK31.61610815
22NLK1.56597250
23CDC71.40214025
24MARK11.40020929
25ADRBK21.35783608
26GRK11.33874616
27CASK1.32128810
28MAPK131.31441006
29VRK21.26231359
30EPHA41.25214846
31PINK11.19597234
32OXSR11.17720565
33PIK3CA1.16783443
34CHEK21.10135254
35PKN11.05917954
36SGK21.05608750
37CSNK1G11.00703007
38LATS10.95726806
39WNK10.95018413
40PLK20.90832424
41GRK70.89957676
42TTK0.85864449
43CAMKK20.81953703
44TESK20.80267746
45PLK10.78825941
46RPS6KA50.75712811
47TNK20.74798403
48MAP2K70.72782045
49TRIM280.72437406
50AURKB0.71648661
51MELK0.67016436
52TGFBR10.65299185
53NTRK20.64902170
54PBK0.61831068
55CSNK1G20.61596741
56CSNK1D0.57197236
57PLK30.56435150
58MARK20.56187615
59LATS20.55330979
60CAMK40.55090866
61PRKCE0.54697299
62STK38L0.54658442
63CDK30.54584186
64CAMK2A0.53516960
65DYRK30.53063725
66CAMK10.52937142
67PRKACA0.52875305
68SGK2230.50264480
69SGK4940.50264480
70CSNK1E0.48488708
71NME10.48346231
72ADRBK10.45686603
73MAP2K60.42987713
74ATM0.42358838
75MAP2K30.41903409
76ITK0.40915252
77PNCK0.40598659
78GRK50.39370773
79ICK0.38682492
80MAPK150.38650346
81STK30.38620769
82DYRK20.38070657
83PIM10.37884628
84PRKCG0.37811734
85MINK10.36323710
86MAP3K30.36222511
87MAP3K40.36199711
88DYRK1A0.34308067
89CSNK1G30.34279918
90PRKCQ0.32468737
91CDK50.32367136
92CHEK10.31980559
93PIM20.31419471
94PRKCZ0.29101619
95PRKG10.28812679
96IRAK10.28752670
97CSNK1A10.28713035
98PIK3CG0.27502028
99PRKCA0.26565882
100PRKACB0.25398809

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.82538807
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.80156471
3Basal transcription factors_Homo sapiens_hsa030222.73875645
4Dorso-ventral axis formation_Homo sapiens_hsa043202.72281462
5Phototransduction_Homo sapiens_hsa047442.65699321
6Homologous recombination_Homo sapiens_hsa034402.33290401
7Tryptophan metabolism_Homo sapiens_hsa003802.14261513
8Nicotine addiction_Homo sapiens_hsa050331.99536504
9Ribosome_Homo sapiens_hsa030101.98430236
10Fanconi anemia pathway_Homo sapiens_hsa034601.98229448
11Linoleic acid metabolism_Homo sapiens_hsa005911.96423203
12Mismatch repair_Homo sapiens_hsa034301.90389820
13Butanoate metabolism_Homo sapiens_hsa006501.75720678
14RNA polymerase_Homo sapiens_hsa030201.65748762
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62918211
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59520394
17Olfactory transduction_Homo sapiens_hsa047401.59380649
18Bile secretion_Homo sapiens_hsa049761.56354864
19Sulfur metabolism_Homo sapiens_hsa009201.50622854
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44157558
21Insulin secretion_Homo sapiens_hsa049111.42351238
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.41549534
23RNA degradation_Homo sapiens_hsa030181.40030564
24Retinol metabolism_Homo sapiens_hsa008301.35466879
25Chemical carcinogenesis_Homo sapiens_hsa052041.35420413
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34648767
27Morphine addiction_Homo sapiens_hsa050321.33269898
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32045417
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31390052
30Huntingtons disease_Homo sapiens_hsa050161.31070837
31Oxidative phosphorylation_Homo sapiens_hsa001901.28946837
32GABAergic synapse_Homo sapiens_hsa047271.27670302
33Ovarian steroidogenesis_Homo sapiens_hsa049131.23289749
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.15929396
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14430910
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14247520
37Serotonergic synapse_Homo sapiens_hsa047261.14039671
38Parkinsons disease_Homo sapiens_hsa050121.13414475
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12110595
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10351634
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04890954
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.04879844
43Circadian entrainment_Homo sapiens_hsa047131.04405383
44Circadian rhythm_Homo sapiens_hsa047101.02021740
45Protein export_Homo sapiens_hsa030600.98662805
46RNA transport_Homo sapiens_hsa030130.96072071
47Taste transduction_Homo sapiens_hsa047420.94986330
48Salivary secretion_Homo sapiens_hsa049700.91338223
49Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91330329
50Non-homologous end-joining_Homo sapiens_hsa034500.90749456
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88902179
52Dopaminergic synapse_Homo sapiens_hsa047280.87272719
53Cocaine addiction_Homo sapiens_hsa050300.87221144
54Cholinergic synapse_Homo sapiens_hsa047250.85859391
55Vitamin B6 metabolism_Homo sapiens_hsa007500.83885759
56Hedgehog signaling pathway_Homo sapiens_hsa043400.83014645
57Steroid biosynthesis_Homo sapiens_hsa001000.82921820
58Cardiac muscle contraction_Homo sapiens_hsa042600.82889935
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.81455077
60Purine metabolism_Homo sapiens_hsa002300.79195283
61Nitrogen metabolism_Homo sapiens_hsa009100.79157997
62Alcoholism_Homo sapiens_hsa050340.78208871
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.78107705
64Glutamatergic synapse_Homo sapiens_hsa047240.77874158
65Fatty acid biosynthesis_Homo sapiens_hsa000610.75183067
66Oocyte meiosis_Homo sapiens_hsa041140.74931963
67mRNA surveillance pathway_Homo sapiens_hsa030150.73273127
68Arachidonic acid metabolism_Homo sapiens_hsa005900.72830552
69Caffeine metabolism_Homo sapiens_hsa002320.71042949
70Calcium signaling pathway_Homo sapiens_hsa040200.67976966
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66616372
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66375350
73Systemic lupus erythematosus_Homo sapiens_hsa053220.64019407
74cAMP signaling pathway_Homo sapiens_hsa040240.60964565
75Ether lipid metabolism_Homo sapiens_hsa005650.60328086
76Collecting duct acid secretion_Homo sapiens_hsa049660.58841597
77Basal cell carcinoma_Homo sapiens_hsa052170.57961075
78Starch and sucrose metabolism_Homo sapiens_hsa005000.55014360
79Amphetamine addiction_Homo sapiens_hsa050310.54747418
80Hippo signaling pathway_Homo sapiens_hsa043900.53091018
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52499108
82Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51992676
83Vitamin digestion and absorption_Homo sapiens_hsa049770.50853344
84Lysine degradation_Homo sapiens_hsa003100.49703678
85Pyrimidine metabolism_Homo sapiens_hsa002400.49161915
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46082052
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45229316
88ABC transporters_Homo sapiens_hsa020100.42782784
89Selenocompound metabolism_Homo sapiens_hsa004500.41036042
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40970606
91Alzheimers disease_Homo sapiens_hsa050100.40038975
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38618272
93Regulation of autophagy_Homo sapiens_hsa041400.37767827
94Synaptic vesicle cycle_Homo sapiens_hsa047210.37480287
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35892205
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34802909
97Type II diabetes mellitus_Homo sapiens_hsa049300.33769946
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33547397
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.31696436
100Metabolic pathways_Homo sapiens_hsa011000.31335660

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »