FPR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.33811939
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.31998296
3negative regulation of cell killing (GO:0031342)6.31998296
4response to peptidoglycan (GO:0032494)6.15623160
5positive regulation of gamma-delta T cell activation (GO:0046645)5.82542925
6hydrogen peroxide biosynthetic process (GO:0050665)5.69396172
7leukocyte aggregation (GO:0070486)5.64758101
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.61717291
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.61717291
10modulation by symbiont of host immune response (GO:0052553)5.61717291
11positive regulation by symbiont of host defense response (GO:0052509)5.61717291
12modulation by symbiont of host defense response (GO:0052031)5.61717291
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.61717291
14respiratory burst (GO:0045730)5.47659695
15production of molecular mediator involved in inflammatory response (GO:0002532)5.30408217
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.19220410
17reactive oxygen species biosynthetic process (GO:1903409)5.05622132
18granulocyte activation (GO:0036230)5.02194858
19antigen processing and presentation of endogenous antigen (GO:0019883)4.99465047
20regulation of B cell receptor signaling pathway (GO:0050855)4.96974881
21superoxide anion generation (GO:0042554)4.96187427
22neutrophil activation (GO:0042119)4.86638149
23lipopolysaccharide-mediated signaling pathway (GO:0031663)4.85343147
24positive regulation of chemokine biosynthetic process (GO:0045080)4.81082888
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.74767657
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.62467619
27leukocyte migration involved in inflammatory response (GO:0002523)4.58871645
28positive regulation of mast cell degranulation (GO:0043306)4.44596368
29positive regulation of mast cell activation involved in immune response (GO:0033008)4.44596368
30positive regulation of interferon-alpha production (GO:0032727)4.40956467
31immunoglobulin mediated immune response (GO:0016064)4.40471176
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.39156907
33macrophage activation involved in immune response (GO:0002281)4.34352149
34response to interleukin-15 (GO:0070672)4.34037430
35response to host immune response (GO:0052572)4.31704204
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.31704204
37positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.24563932
38regulation of gamma-delta T cell activation (GO:0046643)4.23236426
39positive regulation of mast cell activation (GO:0033005)4.21893599
40positive regulation of heat generation (GO:0031652)4.20834490
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.19394630
42regulation of fever generation (GO:0031620)4.18238629
43regulation of interferon-alpha production (GO:0032647)4.17074958
44regulation of chemokine biosynthetic process (GO:0045073)4.12812965
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.10641319
46cellular response to interleukin-15 (GO:0071350)4.02629929
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.97558463
48neutrophil mediated immunity (GO:0002446)3.88614948
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.87789070
50response to host (GO:0075136)3.87789070
51response to host defenses (GO:0052200)3.87789070
52detection of other organism (GO:0098543)3.85947287
53cellular extravasation (GO:0045123)3.80493821
54negative regulation of leukocyte mediated immunity (GO:0002704)3.77519438
55positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.77008905
56negative regulation of T cell mediated immunity (GO:0002710)3.76049161
57T-helper 1 type immune response (GO:0042088)3.74838477
58negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.72641060
59positive regulation of cellular amide metabolic process (GO:0034250)3.72195956
60cellular response to type I interferon (GO:0071357)3.71819423
61type I interferon signaling pathway (GO:0060337)3.71819423
62positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.70498965
63natural killer cell mediated cytotoxicity (GO:0042267)3.68657406
64natural killer cell mediated immunity (GO:0002228)3.68657406
65response to type I interferon (GO:0034340)3.68477366
66leukocyte mediated cytotoxicity (GO:0001909)3.67613269
67positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.66779073
68detection of molecule of bacterial origin (GO:0032490)3.63068947
69regulation of gamma-delta T cell differentiation (GO:0045586)3.61234409
70regulation of mast cell degranulation (GO:0043304)3.60440632
71regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.56185818
72myeloid cell activation involved in immune response (GO:0002275)3.55396810
73regulation of interferon-beta biosynthetic process (GO:0045357)3.45595838
74detection of external biotic stimulus (GO:0098581)3.45070140
75positive regulation of leukocyte degranulation (GO:0043302)3.44987668
76neutrophil chemotaxis (GO:0030593)3.44532593
77defense response to protozoan (GO:0042832)3.44133375
78negative regulation of viral genome replication (GO:0045071)3.42347850
79detection of bacterium (GO:0016045)3.40312893
80regulation of podosome assembly (GO:0071801)3.38227861
81antigen processing and presentation via MHC class Ib (GO:0002475)3.37670314
82negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.36550677
83regulation of mast cell activation (GO:0033003)3.36425314
84positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.35610226
85regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.35368566
86neutrophil migration (GO:1990266)3.35162708
87interferon-gamma-mediated signaling pathway (GO:0060333)3.34776491
88regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.34227793
89regulation of mast cell activation involved in immune response (GO:0033006)3.34197309
90regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.33938385
91B cell mediated immunity (GO:0019724)3.33169337
92positive regulation of toll-like receptor signaling pathway (GO:0034123)3.30947751
93cellular response to exogenous dsRNA (GO:0071360)3.30298297
94regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.29966451
95B cell receptor signaling pathway (GO:0050853)3.28253984
96cellular response to interferon-alpha (GO:0035457)3.26730826
97dendritic cell migration (GO:0036336)3.24239284
98microglial cell activation (GO:0001774)3.23550924
99negative regulation of interleukin-17 production (GO:0032700)3.22378521
100cellular response to zinc ion (GO:0071294)3.22265627
101germinal center formation (GO:0002467)3.21282372
102macrophage activation (GO:0042116)3.20330816
103negative regulation of interleukin-12 production (GO:0032695)3.19977647
104response to muramyl dipeptide (GO:0032495)3.18913108
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.18026364
106positive regulation of type 2 immune response (GO:0002830)3.17341512
107regulation of T-helper 1 cell differentiation (GO:0045625)3.17028483
108negative regulation of T-helper cell differentiation (GO:0045623)3.16873803
109negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16873803
110leukocyte degranulation (GO:0043299)3.16404136
111negative regulation of myeloid cell apoptotic process (GO:0033033)3.16224437
112regulation of heterotypic cell-cell adhesion (GO:0034114)3.15800222
113positive regulation of interferon-beta production (GO:0032728)3.15446010
114regulation of heat generation (GO:0031650)3.15030729
115dendritic cell chemotaxis (GO:0002407)3.14647617
116phagosome maturation (GO:0090382)3.14551241
117regulation of tolerance induction (GO:0002643)3.14342143
118regulation of T-helper 2 cell differentiation (GO:0045628)3.13403908
119sequestering of metal ion (GO:0051238)3.13288821
120myeloid leukocyte mediated immunity (GO:0002444)3.11652293
121regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11166693
122response to interferon-alpha (GO:0035455)3.10939743
123positive regulation of NF-kappaB import into nucleus (GO:0042346)3.10555348
124regulation of vitamin D biosynthetic process (GO:0060556)3.07501194
125granulocyte chemotaxis (GO:0071621)3.06736014
126lymphocyte chemotaxis (GO:0048247)3.06614139
127regulation of T cell tolerance induction (GO:0002664)3.05784172
128cellular response to interferon-beta (GO:0035458)3.04947917
129negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01988922
130granulocyte migration (GO:0097530)3.01857595
131regulation of T cell mediated cytotoxicity (GO:0001914)3.01686647
132regulation of leukocyte degranulation (GO:0043300)3.01294561
133cytokine secretion (GO:0050663)3.00977403
134myeloid leukocyte activation (GO:0002274)3.00869444
135detection of biotic stimulus (GO:0009595)3.00508267
136positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.00087932
137regulation of B cell differentiation (GO:0045577)2.99506011
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96960621
139negative regulation of interleukin-6 production (GO:0032715)2.92906410
140negative regulation of type 2 immune response (GO:0002829)2.92095262
141response to protozoan (GO:0001562)2.87247197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.17660824
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.32534333
3IRF8_22096565_ChIP-ChIP_GC-B_Human6.73603185
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.60070355
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.37179717
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.16274232
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.01447802
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.72398351
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.68856870
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.27263503
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.25166086
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22625691
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08997971
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.77460259
15STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.73928971
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.71002689
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.56231779
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.45574558
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21691689
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13595074
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07665967
22SPI1_23547873_ChIP-Seq_NB4_Human2.02989999
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.82651725
24PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.77305544
25CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69007716
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.66897835
27CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66742283
28TCF7_22412390_ChIP-Seq_EML_Mouse1.64899383
29VDR_24787735_ChIP-Seq_THP-1_Human1.64195062
30* PU_27001747_Chip-Seq_BMDM_Mouse1.62217068
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59994473
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58331360
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54990058
34VDR_24763502_ChIP-Seq_THP-1_Human1.54765586
35MYB_26560356_Chip-Seq_TH2_Human1.50816362
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48769438
37MYC_22102868_ChIP-Seq_BL_Human1.48412890
38RUNX_20019798_ChIP-Seq_JUKART_Human1.42610494
39SPI1_23127762_ChIP-Seq_K562_Human1.40665949
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39632118
41KDM2B_26808549_Chip-Seq_DND41_Human1.39085356
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.38192326
43CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38150540
44TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38079760
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.31903132
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31487590
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29648408
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26220169
49MAF_26560356_Chip-Seq_TH1_Human1.23104872
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22791326
51GATA3_26560356_Chip-Seq_TH2_Human1.21245183
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21062976
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21046711
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19467615
55LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18291182
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17961343
57SCL_19346495_ChIP-Seq_HPC-7_Human1.16652280
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15010725
59PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14053405
60EGR1_19032775_ChIP-ChIP_M12_Human1.13239190
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11993111
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11751653
63MYB_26560356_Chip-Seq_TH1_Human1.11542032
64VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.10620513
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10089651
66GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09641388
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08857409
68GATA3_27048872_Chip-Seq_THYMUS_Human1.07000717
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06810933
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04581855
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.03716126
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00891682
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00891682
74GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98525248
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97276380
76GATA1_22025678_ChIP-Seq_K562_Human0.96819728
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95489868
78EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94747670
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94483863
80KDM2B_26808549_Chip-Seq_JURKAT_Human0.94086402
81LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93658591
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93522231
83NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92208515
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91810406
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.88600819
86BCL6_27268052_Chip-Seq_Bcells_Human0.87783401
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87150348
88SOX2_20726797_ChIP-Seq_SW620_Human0.85626415
89UTX_26944678_Chip-Seq_JUKART_Human0.82920427
90E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82079081
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81511619
92VDR_21846776_ChIP-Seq_THP-1_Human0.81283120
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80717990
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.80648266
95GATA1_19941827_ChIP-Seq_MEL86_Mouse0.80434796
96SPI1_20517297_ChIP-Seq_HL60_Human0.77121557
97BCOR_27268052_Chip-Seq_Bcells_Human0.76565081
98GATA2_19941826_ChIP-Seq_K562_Human0.74969595
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74108821
100GATA1_19941826_ChIP-Seq_K562_Human0.73048300
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73026990
102JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72586825
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.71319267
104LXR_22292898_ChIP-Seq_THP-1_Human0.69822219
105NCOR1_26117541_ChIP-Seq_K562_Human0.68792977
106TP63_17297297_ChIP-ChIP_HaCaT_Human0.66974103
107JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66801381
108SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66241816
109RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.66222388
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64165469
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.63608681
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63385020
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.62489419
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.62433143
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.61013315
116MAF_26560356_Chip-Seq_TH2_Human0.60729003
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.59241084
118PU.1_20513432_ChIP-Seq_Bcells_Mouse0.58913405
119SMRT_27268052_Chip-Seq_Bcells_Human0.58704530
120LXR_22158963_ChIP-Seq_LIVER_Mouse0.57321166
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.57163711
122CJUN_26792858_Chip-Seq_BT549_Human0.56323765
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.56279828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009785_altered_susceptibility_to4.87900138
2MP0003436_decreased_susceptibility_to4.71353472
3MP0001835_abnormal_antigen_presentation4.24177603
4MP0002148_abnormal_hypersensitivity_rea3.87257115
5MP0003303_peritoneal_inflammation3.69250438
6* MP0002419_abnormal_innate_immunity3.59216817
7MP0006082_CNS_inflammation3.53255431
8MP0005025_abnormal_response_to3.35386671
9* MP0005000_abnormal_immune_tolerance3.31882087
10MP0001790_abnormal_immune_system2.76081374
11MP0005387_immune_system_phenotype2.76081374
12MP0009764_decreased_sensitivity_to2.67188404
13MP0004510_myositis2.63018414
14MP0000685_abnormal_immune_system2.61924997
15* MP0002452_abnormal_antigen_presenting2.60978130
16* MP0003724_increased_susceptibility_to2.58981033
17* MP0002723_abnormal_immune_serum2.53062723
18* MP0001800_abnormal_humoral_immune2.38835027
19MP0005167_abnormal_blood-brain_barrier2.38718273
20MP0005058_abnormal_lysosome_morphology2.36147062
21MP0003075_altered_response_to2.33493836
22* MP0001533_abnormal_skeleton_physiology2.32833669
23MP0005671_abnormal_response_to2.29013279
24* MP0001819_abnormal_immune_cell2.25397259
25* MP0002420_abnormal_adaptive_immunity2.20839323
26MP0005464_abnormal_platelet_physiology2.14588201
27MP0002132_abnormal_respiratory_system2.10214101
28MP0004947_skin_inflammation2.07341104
29* MP0001845_abnormal_inflammatory_respons2.05395993
30MP0001853_heart_inflammation1.97415342
31MP0000343_altered_response_to1.94820883
32MP0002006_tumorigenesis1.94208784
33MP0003448_altered_tumor_morphology1.92479074
34MP0002405_respiratory_system_inflammati1.88968867
35MP0008469_abnormal_protein_level1.88014023
36MP0003763_abnormal_thymus_physiology1.87191747
37MP0000858_altered_metastatic_potential1.79871945
38MP0000465_gastrointestinal_hemorrhage1.66181385
39MP0005166_decreased_susceptibility_to1.62790140
40MP0003866_abnormal_defecation1.59362693
41MP0004381_abnormal_hair_follicle1.57493153
42MP0010155_abnormal_intestine_physiology1.54961168
43MP0003186_abnormal_redox_activity1.52920858
44MP0002998_abnormal_bone_remodeling1.51221348
45MP0003172_abnormal_lysosome_physiology1.47483650
46* MP0000716_abnormal_immune_system1.46167755
47MP0003191_abnormal_cellular_cholesterol1.39563424
48MP0002396_abnormal_hematopoietic_system1.39061258
49MP0000703_abnormal_thymus_morphology1.34094120
50MP0005310_abnormal_salivary_gland1.32720522
51MP0002398_abnormal_bone_marrow1.31255525
52MP0003195_calcinosis1.27454437
53MP0003183_abnormal_peptide_metabolism1.24199692
54MP0003828_pulmonary_edema1.22993273
55* MP0005164_abnormal_response_to1.22527314
56MP0004782_abnormal_surfactant_physiolog1.20706017
57MP0005076_abnormal_cell_differentiation1.15493961
58MP0002332_abnormal_exercise_endurance1.13017827
59* MP0002429_abnormal_blood_cell1.12129075
60MP0009333_abnormal_splenocyte_physiolog1.11976101
61MP0000604_amyloidosis1.11855506
62MP0003690_abnormal_glial_cell1.11783335
63MP0009763_increased_sensitivity_to1.11608616
64MP0008260_abnormal_autophagy1.09397261
65MP0004883_abnormal_blood_vessel1.05782350
66* MP0005390_skeleton_phenotype1.04745144
67MP0004858_abnormal_nervous_system1.03209844
68MP0002933_joint_inflammation1.02808063
69MP0001851_eye_inflammation1.02437358
70MP0002138_abnormal_hepatobiliary_system1.01712287
71MP0000689_abnormal_spleen_morphology1.00265517
72* MP0009278_abnormal_bone_marrow0.99340795
73* MP0002277_abnormal_respiratory_mucosa0.98556873
74MP0003646_muscle_fatigue0.93655384
75MP0009840_abnormal_foam_cell0.92967096
76MP0003453_abnormal_keratinocyte_physiol0.91264634
77MP0001663_abnormal_digestive_system0.86703617
78* MP0002722_abnormal_immune_system0.86285690
79MP0003221_abnormal_cardiomyocyte_apopto0.86129155
80MP0005075_abnormal_melanosome_morpholog0.85867650
81MP0000569_abnormal_digit_pigmentation0.84704057
82MP0000015_abnormal_ear_pigmentation0.82989642
83* MP0001545_abnormal_hematopoietic_system0.78829770
84* MP0005397_hematopoietic_system_phenotyp0.78829770
85MP0005535_abnormal_body_temperature0.77179845
86MP0004130_abnormal_muscle_cell0.76267390
87MP0000249_abnormal_blood_vessel0.76166779
88MP0003806_abnormal_nucleotide_metabolis0.75197920
89MP0010352_gastrointestinal_tract_polyps0.74351877
90MP0002166_altered_tumor_susceptibility0.74300401
91MP0001958_emphysema0.71643788
92MP0008874_decreased_physiological_sensi0.71468221
93MP0003656_abnormal_erythrocyte_physiolo0.70538904
94MP0004484_altered_response_of0.68440038
95MP0000920_abnormal_myelination0.67887592
96MP0000371_diluted_coat_color0.67529707
97MP0005451_abnormal_body_composition0.66752769
98MP0003795_abnormal_bone_structure0.65924632
99MP0010307_abnormal_tumor_latency0.65262664
100MP0001986_abnormal_taste_sensitivity0.64825409
101MP0003566_abnormal_cell_adhesion0.63942345
102MP0003787_abnormal_imprinting0.62619001
103MP0001501_abnormal_sleep_pattern0.62301439
104MP0003300_gastrointestinal_ulcer0.61954407
105MP0003045_fibrosis0.59292766
106MP0005319_abnormal_enzyme/_coenzyme0.59243665
107MP0003091_abnormal_cell_migration0.57585010
108MP0005174_abnormal_tail_pigmentation0.57561986
109MP0001873_stomach_inflammation0.56955441
110MP0002928_abnormal_bile_duct0.56475824
111MP0002133_abnormal_respiratory_system0.55534039
112MP0005388_respiratory_system_phenotype0.55534039
113MP0008004_abnormal_stomach_pH0.54186983
114MP0008873_increased_physiological_sensi0.53783403
115MP0000767_abnormal_smooth_muscle0.53529760
116MP0002136_abnormal_kidney_physiology0.53434617
117MP0000490_abnormal_crypts_of0.53212905
118MP0003878_abnormal_ear_physiology0.52732087
119MP0005377_hearing/vestibular/ear_phenot0.52732087
120MP0005023_abnormal_wound_healing0.52513197
121MP0004808_abnormal_hematopoietic_stem0.51451368
122MP0002693_abnormal_pancreas_physiology0.51247599
123MP0002254_reproductive_system_inflammat0.50763529
124MP0006054_spinal_hemorrhage0.50201073
125MP0009765_abnormal_xenobiotic_induced0.49876458
126MP0005584_abnormal_enzyme/coenzyme_acti0.48758749

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)9.05560284
2Recurrent abscess formation (HP:0002722)8.81124354
3Recurrent bacterial skin infections (HP:0005406)8.26741418
4Recurrent gram-negative bacterial infections (HP:0005420)8.19932810
5Mediastinal lymphadenopathy (HP:0100721)6.12354350
6Abnormality of macrophages (HP:0004311)5.79805125
7Gingivitis (HP:0000230)5.26596055
8Stomatitis (HP:0010280)5.11860762
9Autoimmune thrombocytopenia (HP:0001973)4.97843083
10Obstructive lung disease (HP:0006536)4.83375805
11Chronic obstructive pulmonary disease (HP:0006510)4.83375805
12Recurrent skin infections (HP:0001581)4.79995995
13Elevated erythrocyte sedimentation rate (HP:0003565)4.71768387
14Myositis (HP:0100614)4.43713733
15Increased IgM level (HP:0003496)4.41452977
16Orchitis (HP:0100796)4.32393003
17Recurrent fungal infections (HP:0002841)4.13805009
18Encephalitis (HP:0002383)3.98063464
19Retrobulbar optic neuritis (HP:0100654)3.95640879
20Optic neuritis (HP:0100653)3.95640879
21Vasculitis (HP:0002633)3.87509587
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.86963673
23Urticaria (HP:0001025)3.84971621
24Hypochromic microcytic anemia (HP:0004840)3.76345950
25Cellulitis (HP:0100658)3.59094193
26Interstitial pulmonary disease (HP:0006530)3.44402392
27Periodontitis (HP:0000704)3.39115063
28Chest pain (HP:0100749)3.35019350
29Systemic lupus erythematosus (HP:0002725)3.34170875
30Increased IgE level (HP:0003212)3.34099756
31T lymphocytopenia (HP:0005403)3.32192980
32Episodic fever (HP:0001954)3.31785368
33Axonal loss (HP:0003447)3.25778648
34Vacuolated lymphocytes (HP:0001922)3.20925287
35Basal ganglia calcification (HP:0002135)3.19536203
36Hypochromic anemia (HP:0001931)3.18849599
37Recurrent viral infections (HP:0004429)3.11315236
38Pustule (HP:0200039)3.10178880
39Recurrent pneumonia (HP:0006532)3.08217074
40Thick nail (HP:0001805)3.07941750
41Prolonged bleeding time (HP:0003010)3.05340784
42Meningitis (HP:0001287)3.03910858
43Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01798312
44Prostate neoplasm (HP:0100787)2.97542883
45Tetraparesis (HP:0002273)2.84696911
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.83957242
47Hypergammaglobulinemia (HP:0010702)2.79533960
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.78361067
49Spontaneous hematomas (HP:0007420)2.76209371
50Increased cerebral lipofuscin (HP:0011813)2.75738646
51Chronic mucocutaneous candidiasis (HP:0002728)2.72364236
52Recurrent cutaneous fungal infections (HP:0011370)2.72364236
53Pulmonary infiltrates (HP:0002113)2.70798289
54Abnormality of T cells (HP:0002843)2.67244510
55Recurrent lower respiratory tract infections (HP:0002783)2.67158533
56Abnormality of the peritoneum (HP:0002585)2.61116529
57Autoimmune hemolytic anemia (HP:0001890)2.60245212
58Gastrointestinal infarctions (HP:0005244)2.59459101
59Osteomyelitis (HP:0002754)2.59230769
60Hemoptysis (HP:0002105)2.52692641
61Gingival bleeding (HP:0000225)2.52521954
62Leukocytosis (HP:0001974)2.48688882
63Inflammation of the large intestine (HP:0002037)2.47914585
64Poor head control (HP:0002421)2.46018708
65Abnormality of the endocardium (HP:0004306)2.43435245
66Granulocytopenia (HP:0001913)2.43001268
67Glomerulonephritis (HP:0000099)2.40244922
68Hepatosplenomegaly (HP:0001433)2.40010067
69Keratitis (HP:0000491)2.38459808
70Keratoconjunctivitis sicca (HP:0001097)2.38354194
71Microcytic anemia (HP:0001935)2.38315426
72Disinhibition (HP:0000734)2.35369080
73Gastrointestinal inflammation (HP:0004386)2.34737092
74Peritonitis (HP:0002586)2.34204392
75Hematochezia (HP:0002573)2.29772019
76Glomerulopathy (HP:0100820)2.28547262
77Premature loss of primary teeth (HP:0006323)2.28235939
78Vertigo (HP:0002321)2.28017065
79Arterial thrombosis (HP:0004420)2.23131178
80Joint hemorrhage (HP:0005261)2.21929160
81Acne (HP:0001061)2.21199951
82Osteolytic defects of the hand bones (HP:0009699)2.18768482
83Osteolytic defects of the phalanges of the hand (HP:0009771)2.18768482
84Sepsis (HP:0100806)2.18623579
85Keratoconjunctivitis (HP:0001096)2.16365895
86Abnormality of T cell physiology (HP:0011840)2.15646281
87Chronic otitis media (HP:0000389)2.12554843
88Abnormality of T cell number (HP:0011839)2.09209040
89Panhypogammaglobulinemia (HP:0003139)2.08699577
90Lymphopenia (HP:0001888)2.08657512
91Joint swelling (HP:0001386)2.08176047
92Porencephaly (HP:0002132)2.05879684
93Acute hepatic failure (HP:0006554)2.05624488
94Subacute progressive viral hepatitis (HP:0006572)2.05598766
95Skin ulcer (HP:0200042)2.00215717
96Petechiae (HP:0000967)2.00166828
97Slow saccadic eye movements (HP:0000514)1.99832837
98Nephritis (HP:0000123)1.99651922
99Abnormality of the pericardium (HP:0001697)1.98135093
100Arthralgia (HP:0002829)1.97931102
101Dysostosis multiplex (HP:0000943)1.97828605
102Polyneuropathy (HP:0001271)1.96812040
103Myocardial infarction (HP:0001658)1.95057878
104Recurrent bronchitis (HP:0002837)1.94718160
105Purpura (HP:0000979)1.93768758
106Abnormality of the pleura (HP:0002103)1.93528049
107Anorexia (HP:0002039)1.92302845
108Bone pain (HP:0002653)1.90952963
109Thrombophlebitis (HP:0004418)1.90751983
110Epistaxis (HP:0000421)1.89140846
111Agnosia (HP:0010524)1.88703786
112Neoplasm of head and neck (HP:0012288)1.88695797
113Esophageal neoplasm (HP:0100751)1.88695797
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88476380
115Amyloidosis (HP:0011034)1.86324696
116Abnormality of eosinophils (HP:0001879)1.85893007
117Viral hepatitis (HP:0006562)1.85738422
118Cheilitis (HP:0100825)1.85687968
119Pulmonary embolism (HP:0002204)1.85563231
120Skin rash (HP:0000988)1.83025202
121Abnormality of cells of the lymphoid lineage (HP:0012140)1.82355615
122Segmental peripheral demyelination/remyelination (HP:0003481)1.82106422
123Loss of speech (HP:0002371)1.81380483
124Abnormality of liposaccharide metabolism (HP:0010968)1.80960937
125Abnormality of glycosphingolipid metabolism (HP:0004343)1.80960937
126Abnormality of glycolipid metabolism (HP:0010969)1.80960937
127Eosinophilia (HP:0001880)1.80368914
128Metaphyseal cupping (HP:0003021)1.79661691
129Parakeratosis (HP:0001036)1.79488395
130Abnormal platelet volume (HP:0011876)1.79230842
131Increased serum ferritin (HP:0003281)1.79219216
132Difficulty running (HP:0009046)1.76174826
133Vertebral compression fractures (HP:0002953)1.75897793
134Progressive visual loss (HP:0000529)1.74728778
135Colitis (HP:0002583)1.73809059
136Gangrene (HP:0100758)1.73808063
137Gastrointestinal stroma tumor (HP:0100723)1.73322751
138Esophageal varix (HP:0002040)1.73098064
139Nausea (HP:0002018)1.72985734
140Polycythemia (HP:0001901)1.72951541
141Hypermelanotic macule (HP:0001034)1.71976320
142Amaurosis fugax (HP:0100576)1.71423951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK46.17105040
2PBK4.77941158
3MAP3K144.38674803
4BLK3.82456484
5IRAK43.77060146
6TBK13.21990648
7IRAK32.56338569
8TYK22.53363793
9CSK2.48368260
10IKBKE2.44848131
11ERN12.41378025
12IKBKB2.07137589
13TNK22.05459451
14FGR2.03443390
15TXK1.99620432
16JAK31.96528065
17TAOK11.78904176
18MAP3K31.74872428
19JAK11.67014128
20MAP4K11.63822953
21PRPF4B1.60325371
22EPHB11.59584610
23MAP3K131.46497426
24BMPR21.46094765
25PIM21.42269408
26HCK1.42073409
27RIPK11.30179402
28MARK31.26841563
29ZAP701.24047138
30MATK1.23826110
31BTK1.22651186
32YES11.20844649
33LYN1.20344772
34MST41.19764755
35SYK1.19181181
36KIT1.18239185
37TEC1.17245529
38MAP3K61.14976183
39CHUK1.11248805
40STK101.09801797
41MAP3K21.08722801
42ABL21.07338057
43JAK20.99033457
44MAP3K50.98759897
45MST1R0.97802228
46STK40.96283568
47CLK10.96212993
48RPS6KA40.94293554
49EIF2AK20.93552435
50MARK20.93490285
51LCK0.92041538
52PIM10.89106852
53CDK190.88759590
54MAP2K40.88611628
55BMX0.85932857
56NEK90.84797018
57ERBB30.84372194
58FES0.82717190
59FGFR40.79059399
60ARAF0.78906306
61TRPM70.78831674
62PRKCD0.78543275
63PTK2B0.78219120
64PRKD20.76268564
65MAP3K120.74948703
66TAOK20.73905104
67CSF1R0.73605116
68KSR20.73420907
69FGFR30.73178135
70RAF10.69994876
71STK110.65757938
72EGFR0.65621824
73EPHA30.65023078
74ABL10.64901425
75IRAK10.63798019
76GRK70.63401975
77MAP2K60.63259495
78KSR10.63255406
79DYRK1B0.62181333
80PRKG20.59568460
81MAP3K70.57306972
82TESK20.55986883
83SGK30.54508021
84NLK0.54430597
85FYN0.54174949
86STK380.53950228
87MAP3K10.53017848
88WNK10.50891190
89IRAK20.50800986
90CDC42BPA0.50132762
91PRKCQ0.49733716
92NME20.48484668
93DYRK30.47784256
94RET0.47637366
95PDPK10.47534215
96MAP2K30.46834069
97SIK30.46759174
98MAP3K110.45957201
99HIPK20.45842697
100STK30.45802803
101LRRK20.45208554
102MAPK120.45005644
103ERBB40.44298390
104ITK0.43052000
105SGK20.42789451
106ADRBK10.42046745
107PRKCZ0.41819513
108TAOK30.40920131
109PDK10.40459636
110MAPK70.37951710
111BMPR1B0.37675253
112TGFBR20.37615871
113TRIB30.36189354
114TESK10.36138185
115RPS6KL10.35417319
116RPS6KC10.35417319
117ALK0.34596386
118SMG10.34055207
119GRK60.33465849
120MOS0.33295879
121MAPKAPK20.31510665
122SIK20.31280404
123CAMKK20.31132754
124DAPK20.27983331
125RPS6KA60.26701162
126PIK3CG0.25665507
127RPS6KA10.24577232
128INSR0.24324945
129IGF1R0.23880835
130ACVR1B0.23735802
131BCR0.23277113
132ADRBK20.22382586
133TTN0.19706471
134KDR0.18163654
135PTK60.17846639
136MAPK40.17583749

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.93001636
2Leishmaniasis_Homo sapiens_hsa051403.82957536
3Toll-like receptor signaling pathway_Homo sapiens_hsa046203.01325745
4* Staphylococcus aureus infection_Homo sapiens_hsa051503.00611644
5Legionellosis_Homo sapiens_hsa051342.98967878
6Asthma_Homo sapiens_hsa053102.73179449
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.72099746
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.66028817
9Allograft rejection_Homo sapiens_hsa053302.63996289
10Type I diabetes mellitus_Homo sapiens_hsa049402.59413065
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.54642567
12Pertussis_Homo sapiens_hsa051332.53082697
13Malaria_Homo sapiens_hsa051442.40271452
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.35945893
15Rheumatoid arthritis_Homo sapiens_hsa053232.34188465
16Osteoclast differentiation_Homo sapiens_hsa043802.29812318
17Tuberculosis_Homo sapiens_hsa051522.28708912
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22561045
19African trypanosomiasis_Homo sapiens_hsa051432.13635856
20Salmonella infection_Homo sapiens_hsa051322.11317367
21TNF signaling pathway_Homo sapiens_hsa046682.10371134
22Measles_Homo sapiens_hsa051622.00092758
23Influenza A_Homo sapiens_hsa051641.88761998
24Phagosome_Homo sapiens_hsa041451.68559760
25Hematopoietic cell lineage_Homo sapiens_hsa046401.60624374
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.57890143
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.51612841
28Chemokine signaling pathway_Homo sapiens_hsa040621.50526472
29Herpes simplex infection_Homo sapiens_hsa051681.49659124
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45260560
31Toxoplasmosis_Homo sapiens_hsa051451.42176157
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26538046
33Shigellosis_Homo sapiens_hsa051311.23093912
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22631035
35Lysosome_Homo sapiens_hsa041421.20103862
36Non-small cell lung cancer_Homo sapiens_hsa052231.19350561
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.16614631
38B cell receptor signaling pathway_Homo sapiens_hsa046621.16029676
39Amoebiasis_Homo sapiens_hsa051461.12018487
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07994138
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07282807
42Apoptosis_Homo sapiens_hsa042101.06526862
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03602015
44Autoimmune thyroid disease_Homo sapiens_hsa053201.03099986
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02275158
46Hepatitis B_Homo sapiens_hsa051610.99741882
47Hepatitis C_Homo sapiens_hsa051600.98210488
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96504303
49Prion diseases_Homo sapiens_hsa050200.96420944
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.95991561
51Viral myocarditis_Homo sapiens_hsa054160.84089313
52Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84054413
53Renal cell carcinoma_Homo sapiens_hsa052110.81591268
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68449130
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.66465153
56Antigen processing and presentation_Homo sapiens_hsa046120.64447748
57Complement and coagulation cascades_Homo sapiens_hsa046100.62208185
58Endometrial cancer_Homo sapiens_hsa052130.61964825
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56997211
60GnRH signaling pathway_Homo sapiens_hsa049120.56950038
61Choline metabolism in cancer_Homo sapiens_hsa052310.56527521
62T cell receptor signaling pathway_Homo sapiens_hsa046600.55816463
63Primary immunodeficiency_Homo sapiens_hsa053400.55714629
64Regulation of autophagy_Homo sapiens_hsa041400.55428917
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55089532
66Collecting duct acid secretion_Homo sapiens_hsa049660.54771423
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.52875980
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.52785922
69Platelet activation_Homo sapiens_hsa046110.52305669
70Other glycan degradation_Homo sapiens_hsa005110.51241326
71Mineral absorption_Homo sapiens_hsa049780.51206753
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50385161
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49854224
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.49525782
75Inositol phosphate metabolism_Homo sapiens_hsa005620.47564152
76mTOR signaling pathway_Homo sapiens_hsa041500.46626444
77Acute myeloid leukemia_Homo sapiens_hsa052210.46429949
78Type II diabetes mellitus_Homo sapiens_hsa049300.46075869
79Dorso-ventral axis formation_Homo sapiens_hsa043200.45339886
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45237686
81Rap1 signaling pathway_Homo sapiens_hsa040150.44286026
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43263493
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.43099876
84Colorectal cancer_Homo sapiens_hsa052100.42056620
85ErbB signaling pathway_Homo sapiens_hsa040120.41825310
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.39126521
87Prolactin signaling pathway_Homo sapiens_hsa049170.38865191
88Pancreatic cancer_Homo sapiens_hsa052120.35779148
89Epstein-Barr virus infection_Homo sapiens_hsa051690.35615901
90Prostate cancer_Homo sapiens_hsa052150.33643953
91HIF-1 signaling pathway_Homo sapiens_hsa040660.33048872
92Chronic myeloid leukemia_Homo sapiens_hsa052200.30485724
93Insulin resistance_Homo sapiens_hsa049310.26203969
94VEGF signaling pathway_Homo sapiens_hsa043700.25969365
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25715279
96Steroid biosynthesis_Homo sapiens_hsa001000.25276460
97Caffeine metabolism_Homo sapiens_hsa002320.23512127
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23076657
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22517857
100Proteoglycans in cancer_Homo sapiens_hsa052050.18083482
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17745545
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.17265438
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16765821
104Pentose phosphate pathway_Homo sapiens_hsa000300.15637472
105FoxO signaling pathway_Homo sapiens_hsa040680.14566418
106Small cell lung cancer_Homo sapiens_hsa052220.14463245
107Endocytosis_Homo sapiens_hsa041440.13843596
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12192741
109Histidine metabolism_Homo sapiens_hsa003400.11905571
110MAPK signaling pathway_Homo sapiens_hsa040100.11417240
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11219850
112Viral carcinogenesis_Homo sapiens_hsa052030.09737442
113Notch signaling pathway_Homo sapiens_hsa043300.08713714
114Proteasome_Homo sapiens_hsa030500.08394202
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05393352
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04316447
117Vibrio cholerae infection_Homo sapiens_hsa051100.03171144
118HTLV-I infection_Homo sapiens_hsa051660.02785039

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