FPGT-TNNI3K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)3.95116247
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89694026
3indolalkylamine metabolic process (GO:0006586)3.87086451
4negative regulation of cytosolic calcium ion concentration (GO:0051481)3.83833050
5protein polyglutamylation (GO:0018095)3.76895646
6behavioral response to nicotine (GO:0035095)3.72768033
7somite development (GO:0061053)3.68989029
8indole-containing compound catabolic process (GO:0042436)3.61952820
9indolalkylamine catabolic process (GO:0046218)3.61952820
10tryptophan catabolic process (GO:0006569)3.61952820
11cellular ketone body metabolic process (GO:0046950)3.48893481
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.34022879
13axoneme assembly (GO:0035082)3.28501344
14water-soluble vitamin biosynthetic process (GO:0042364)3.24444342
15adaptation of signaling pathway (GO:0023058)3.21310130
16DNA deamination (GO:0045006)3.18981307
17negative regulation of mast cell activation (GO:0033004)3.15263812
18detection of light stimulus involved in sensory perception (GO:0050962)3.13494495
19detection of light stimulus involved in visual perception (GO:0050908)3.13494495
20otic vesicle formation (GO:0030916)3.13108681
21epithelial cilium movement (GO:0003351)3.12991435
22ketone body metabolic process (GO:1902224)3.12211804
23photoreceptor cell maintenance (GO:0045494)3.10041139
24sulfation (GO:0051923)3.06761768
25kynurenine metabolic process (GO:0070189)3.05792714
26gamma-aminobutyric acid transport (GO:0015812)3.05402597
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05146628
28tryptophan metabolic process (GO:0006568)3.04415257
29detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.03556416
30neural tube formation (GO:0001841)3.02808752
31reflex (GO:0060004)3.02247489
32behavioral response to ethanol (GO:0048149)2.99412286
33positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.99306557
34indole-containing compound metabolic process (GO:0042430)2.99172134
35piRNA metabolic process (GO:0034587)2.95374386
36regulation of action potential (GO:0098900)2.91363361
37regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.90056977
38interkinetic nuclear migration (GO:0022027)2.89393092
39tachykinin receptor signaling pathway (GO:0007217)2.88473029
40cilium movement (GO:0003341)2.88091420
41regulation of hippo signaling (GO:0035330)2.87075688
42negative regulation of systemic arterial blood pressure (GO:0003085)2.85267700
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.84391618
44regulation of skeletal muscle contraction (GO:0014819)2.81867645
45response to caffeine (GO:0031000)2.80339482
46fucose catabolic process (GO:0019317)2.77356485
47L-fucose metabolic process (GO:0042354)2.77356485
48L-fucose catabolic process (GO:0042355)2.77356485
49neuronal action potential (GO:0019228)2.76290613
50protein complex biogenesis (GO:0070271)2.76078977
51negative regulation of heart rate (GO:0010459)2.75908365
52membrane depolarization during action potential (GO:0086010)2.75490374
53positive regulation of cardiac muscle cell differentiation (GO:2000727)2.75417589
54response to pheromone (GO:0019236)2.75383003
55serotonin metabolic process (GO:0042428)2.73224979
56presynaptic membrane assembly (GO:0097105)2.73170269
57DNA methylation involved in gamete generation (GO:0043046)2.67584220
58positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.65944150
59forebrain morphogenesis (GO:0048853)2.64768001
60GPI anchor metabolic process (GO:0006505)2.62590385
61ubiquinone biosynthetic process (GO:0006744)2.62278436
62positive regulation of action potential (GO:0045760)2.61917320
63primary amino compound metabolic process (GO:1901160)2.57824695
64action potential (GO:0001508)2.57390774
65microtubule anchoring (GO:0034453)2.57054396
66preassembly of GPI anchor in ER membrane (GO:0016254)2.55156662
67cellular biogenic amine catabolic process (GO:0042402)2.55036451
68amine catabolic process (GO:0009310)2.55036451
69aromatic amino acid family catabolic process (GO:0009074)2.54221177
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.52925590
71NADH dehydrogenase complex assembly (GO:0010257)2.52925590
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.52925590
73cilium organization (GO:0044782)2.52646165
74ubiquinone metabolic process (GO:0006743)2.50491231
75negative regulation of response to food (GO:0032096)2.49778611
76negative regulation of appetite (GO:0032099)2.49778611
77seminiferous tubule development (GO:0072520)2.48966501
78kidney morphogenesis (GO:0060993)2.48953194
79nonmotile primary cilium assembly (GO:0035058)2.47403698
80cell proliferation in forebrain (GO:0021846)2.46698447
81pharyngeal system development (GO:0060037)2.46595273
82negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.46333446
83prostate gland growth (GO:0060736)2.45405698
84platelet dense granule organization (GO:0060155)2.44100735
85protein K11-linked deubiquitination (GO:0035871)2.43369298
86signal peptide processing (GO:0006465)2.42768227
87cilium assembly (GO:0042384)2.42157497
88presynaptic membrane organization (GO:0097090)2.41375914
89relaxation of cardiac muscle (GO:0055119)2.40413099
90transmission of nerve impulse (GO:0019226)2.39630510
91thyroid hormone metabolic process (GO:0042403)2.37975013
92mitochondrial respiratory chain complex assembly (GO:0033108)2.36825038
93cAMP catabolic process (GO:0006198)2.35845501
94regulation of mesoderm development (GO:2000380)2.33910390
95regulation of collateral sprouting (GO:0048670)2.33626482
96cellular response to ATP (GO:0071318)2.33383273
97regulation of relaxation of muscle (GO:1901077)2.33082496
98benzene-containing compound metabolic process (GO:0042537)2.32424275
99establishment of protein localization to Golgi (GO:0072600)2.31813221
100motile cilium assembly (GO:0044458)2.31798677

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.55197171
2EZH2_22144423_ChIP-Seq_EOC_Human3.25978096
3VDR_22108803_ChIP-Seq_LS180_Human2.83910233
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71144587
5IGF1R_20145208_ChIP-Seq_DFB_Human2.69624954
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64356991
7ZNF274_21170338_ChIP-Seq_K562_Hela2.61065967
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.58157157
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.46957673
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36091789
11TAF15_26573619_Chip-Seq_HEK293_Human2.32535967
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30333071
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27488689
14FUS_26573619_Chip-Seq_HEK293_Human2.23058439
15P300_19829295_ChIP-Seq_ESCs_Human2.12362924
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.08827953
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04700439
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.94187215
19EWS_26573619_Chip-Seq_HEK293_Human1.92250337
20SMAD4_21799915_ChIP-Seq_A2780_Human1.88777156
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82922167
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81187810
23ER_23166858_ChIP-Seq_MCF-7_Human1.79101098
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72398343
25STAT3_23295773_ChIP-Seq_U87_Human1.70511392
26UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70337427
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69600199
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68731155
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66451301
30MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59226345
31PIAS1_25552417_ChIP-Seq_VCAP_Human1.57618439
32BCAT_22108803_ChIP-Seq_LS180_Human1.54840600
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53843863
34TCF4_23295773_ChIP-Seq_U87_Human1.52925589
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52203738
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49565389
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48942296
38CBP_20019798_ChIP-Seq_JUKART_Human1.48455958
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48455958
40AR_25329375_ChIP-Seq_VCAP_Human1.47598269
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47151140
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.46935171
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44409808
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40744112
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.40625583
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40555754
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.39633599
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39221815
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38096034
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37192651
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.36926070
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.36027776
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.34905974
54SOX2_19829295_ChIP-Seq_ESCs_Human1.34476865
55NANOG_19829295_ChIP-Seq_ESCs_Human1.34476865
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.33413206
57RNF2_27304074_Chip-Seq_NSC_Mouse1.30986360
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30302444
59EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28749946
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27252005
61KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26066483
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24422079
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.23691514
64RUNX2_22187159_ChIP-Seq_PCA_Human1.23490260
65TCF4_22108803_ChIP-Seq_LS180_Human1.21136037
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20347715
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19332430
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.19041075
69P53_22387025_ChIP-Seq_ESCs_Mouse1.17879617
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.17822815
71IRF1_19129219_ChIP-ChIP_H3396_Human1.17388741
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.16749862
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16356574
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16232894
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16232894
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.14357364
77CRX_20693478_ChIP-Seq_RETINA_Mouse1.13667912
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13639894
79REST_21632747_ChIP-Seq_MESCs_Mouse1.12865211
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12025908
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11922473
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11609954
83TP53_22573176_ChIP-Seq_HFKS_Human1.10266561
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.09604483
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09314960
86CDX2_22108803_ChIP-Seq_LS180_Human1.08978563
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.08620074
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.07915473
89FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07302757
90FOXA1_25329375_ChIP-Seq_VCAP_Human1.07302757
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04199556
92AR_21572438_ChIP-Seq_LNCaP_Human1.04179297
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03272490
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02266098
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01795269
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01321600
97SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01269012
98EED_16625203_ChIP-ChIP_MESCs_Mouse1.00986847
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00910587
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00753017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.53965385
2MP0003646_muscle_fatigue3.12209177
3MP0005646_abnormal_pituitary_gland2.63417419
4MP0004145_abnormal_muscle_electrophysio2.61426241
5MP0004215_abnormal_myocardial_fiber2.38433478
6MP0005551_abnormal_eye_electrophysiolog2.35890055
7MP0003195_calcinosis2.22943103
8MP0006292_abnormal_olfactory_placode2.17077371
9MP0006072_abnormal_retinal_apoptosis2.06492113
10MP0004885_abnormal_endolymph1.99354318
11MP0001968_abnormal_touch/_nociception1.92584045
12MP0002102_abnormal_ear_morphology1.84351307
13MP0009745_abnormal_behavioral_response1.82065804
14MP0001485_abnormal_pinna_reflex1.81041027
15MP0008775_abnormal_heart_ventricle1.77678491
16MP0005670_abnormal_white_adipose1.77671780
17MP0002876_abnormal_thyroid_physiology1.76162637
18MP0004142_abnormal_muscle_tone1.71982902
19MP0002653_abnormal_ependyma_morphology1.70793413
20MP0004084_abnormal_cardiac_muscle1.68515046
21MP0000631_abnormal_neuroendocrine_gland1.67566089
22MP0001486_abnormal_startle_reflex1.65194900
23MP0000372_irregular_coat_pigmentation1.64541328
24MP0005253_abnormal_eye_physiology1.63195606
25MP0001984_abnormal_olfaction1.62424296
26MP0001529_abnormal_vocalization1.62173814
27MP0002272_abnormal_nervous_system1.62108893
28MP0003136_yellow_coat_color1.61964836
29MP0008877_abnormal_DNA_methylation1.55787011
30MP0003880_abnormal_central_pattern1.53509753
31MP0002735_abnormal_chemical_nociception1.53375692
32MP0002938_white_spotting1.52647894
33MP0006276_abnormal_autonomic_nervous1.48156628
34MP0003137_abnormal_impulse_conducting1.47790415
35MP0009046_muscle_twitch1.47561836
36MP0003787_abnormal_imprinting1.44481024
37MP0008872_abnormal_physiological_respon1.43920160
38MP0002736_abnormal_nociception_after1.40986015
39MP0004085_abnormal_heartbeat1.38208573
40MP0000383_abnormal_hair_follicle1.37054287
41MP0002234_abnormal_pharynx_morphology1.36838240
42MP0002160_abnormal_reproductive_system1.35607833
43MP0005645_abnormal_hypothalamus_physiol1.27258418
44MP0001986_abnormal_taste_sensitivity1.25757704
45MP0001501_abnormal_sleep_pattern1.25454944
46MP0000569_abnormal_digit_pigmentation1.23857487
47MP0005389_reproductive_system_phenotype1.18128198
48MP0002064_seizures1.17981123
49MP0004147_increased_porphyrin_level1.17913192
50MP0000427_abnormal_hair_cycle1.16262839
51MP0004484_altered_response_of1.13864073
52MP0003283_abnormal_digestive_organ1.12616684
53MP0002572_abnormal_emotion/affect_behav1.11048204
54MP0003635_abnormal_synaptic_transmissio1.09041616
55MP0001970_abnormal_pain_threshold1.08406047
56MP0003011_delayed_dark_adaptation1.08349551
57MP0010386_abnormal_urinary_bladder1.08229337
58MP0003119_abnormal_digestive_system1.07007804
59MP0000013_abnormal_adipose_tissue1.06784023
60MP0004130_abnormal_muscle_cell1.04470719
61MP0004036_abnormal_muscle_relaxation1.04427005
62MP0001963_abnormal_hearing_physiology1.03399812
63MP0005620_abnormal_muscle_contractility1.02102731
64MP0000049_abnormal_middle_ear1.00911256
65MP0002733_abnormal_thermal_nociception0.99763477
66MP0002638_abnormal_pupillary_reflex0.99249873
67MP0005195_abnormal_posterior_eye0.98906908
68MP0000230_abnormal_systemic_arterial0.98157238
69MP0005410_abnormal_fertilization0.97385949
70MP0002734_abnormal_mechanical_nocicepti0.96622055
71MP0003567_abnormal_fetal_cardiomyocyte0.95970075
72MP0002138_abnormal_hepatobiliary_system0.94316620
73MP0005386_behavior/neurological_phenoty0.94193269
74MP0004924_abnormal_behavior0.94193269
75MP0002557_abnormal_social/conspecific_i0.91551668
76MP0002067_abnormal_sensory_capabilities0.91195050
77MP0005075_abnormal_melanosome_morpholog0.89410677
78MP0000026_abnormal_inner_ear0.88006149
79MP0003937_abnormal_limbs/digits/tail_de0.87559841
80MP0002163_abnormal_gland_morphology0.87259284
81MP0005379_endocrine/exocrine_gland_phen0.85128517
82MP0002063_abnormal_learning/memory/cond0.84731166
83MP0004133_heterotaxia0.84568623
84MP0002751_abnormal_autonomic_nervous0.83223851
85MP0002229_neurodegeneration0.82448615
86MP0002693_abnormal_pancreas_physiology0.82212648
87MP0005174_abnormal_tail_pigmentation0.81441992
88MP0008789_abnormal_olfactory_epithelium0.79626710
89MP0001664_abnormal_digestion0.78927654
90MP0005085_abnormal_gallbladder_physiolo0.78218646
91MP0002822_catalepsy0.77589725
92MP0003698_abnormal_male_reproductive0.76948566
93MP0002752_abnormal_somatic_nervous0.76833237
94MP0002127_abnormal_cardiovascular_syste0.73579668
95MP0001919_abnormal_reproductive_system0.71510408
96MP0002095_abnormal_skin_pigmentation0.70467408
97MP0004043_abnormal_pH_regulation0.70097388
98MP0001440_abnormal_grooming_behavior0.69957822
99MP0004742_abnormal_vestibular_system0.69778124
100MP0001905_abnormal_dopamine_level0.67372183

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.14371645
2Pancreatic fibrosis (HP:0100732)4.09664780
3True hermaphroditism (HP:0010459)3.88737170
4Abnormality of midbrain morphology (HP:0002418)3.60600664
5Molar tooth sign on MRI (HP:0002419)3.60600664
6Nephronophthisis (HP:0000090)3.45698922
7Abnormality of the renal cortex (HP:0011035)3.26743720
8Congenital stationary night blindness (HP:0007642)3.06859284
9Medial flaring of the eyebrow (HP:0010747)3.03861502
10Aplasia/Hypoplasia of the tibia (HP:0005772)3.00838931
11Abolished electroretinogram (ERG) (HP:0000550)2.98867180
12Abnormality of the renal medulla (HP:0100957)2.98078889
13Attenuation of retinal blood vessels (HP:0007843)2.97933498
14Renal cortical cysts (HP:0000803)2.87821078
15Abnormal rod and cone electroretinograms (HP:0008323)2.83603505
16Progressive cerebellar ataxia (HP:0002073)2.83230021
17Gaze-evoked nystagmus (HP:0000640)2.72076224
18Methylmalonic acidemia (HP:0002912)2.69273131
19Chronic hepatic failure (HP:0100626)2.66849516
20Genetic anticipation (HP:0003743)2.65270682
21Type II lissencephaly (HP:0007260)2.56423060
22Absent/shortened dynein arms (HP:0200106)2.51342549
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.51342549
24Febrile seizures (HP:0002373)2.51031014
25Cystic liver disease (HP:0006706)2.50885944
26Bony spicule pigmentary retinopathy (HP:0007737)2.49519371
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48993611
28Keratoconus (HP:0000563)2.46371181
29Increased corneal curvature (HP:0100692)2.46371181
30Gait imbalance (HP:0002141)2.45810314
31Genital tract atresia (HP:0001827)2.41794661
32Congenital sensorineural hearing impairment (HP:0008527)2.41623354
33Short tibia (HP:0005736)2.40957509
34Congenital primary aphakia (HP:0007707)2.39304617
35Abnormal ciliary motility (HP:0012262)2.33963591
36Hyperventilation (HP:0002883)2.32033914
37Polydipsia (HP:0001959)2.30032256
38Abnormal drinking behavior (HP:0030082)2.30032256
39Broad-based gait (HP:0002136)2.26953613
40Hyperglycinemia (HP:0002154)2.25872376
41Short hallux (HP:0010109)2.22860511
42Aplasia/Hypoplasia of the tongue (HP:0010295)2.22481147
43Abnormal respiratory motile cilium morphology (HP:0005938)2.22341161
44Abnormal respiratory epithelium morphology (HP:0012253)2.22341161
45Pendular nystagmus (HP:0012043)2.18100947
46Left ventricular hypertrophy (HP:0001712)2.17051453
47Atrial fibrillation (HP:0005110)2.16925810
48Acute necrotizing encephalopathy (HP:0006965)2.16163118
49Vaginal atresia (HP:0000148)2.15105305
50Syncope (HP:0001279)2.15038317
51Nephrogenic diabetes insipidus (HP:0009806)2.14399756
52Male pseudohermaphroditism (HP:0000037)2.13626014
53Methylmalonic aciduria (HP:0012120)2.13545378
54Chorioretinal atrophy (HP:0000533)2.13463972
55Aplasia/Hypoplasia of the hallux (HP:0008362)2.13410199
56Sclerocornea (HP:0000647)2.11015853
57Progressive macrocephaly (HP:0004481)2.06958498
58Abnormality of the nasal septum (HP:0000419)2.05508687
59Hemiparesis (HP:0001269)2.05449893
60Furrowed tongue (HP:0000221)2.04897137
61Focal motor seizures (HP:0011153)2.04216504
62Primary atrial arrhythmia (HP:0001692)2.04092248
63Intestinal atresia (HP:0011100)2.03614731
64Abnormal respiratory motile cilium physiology (HP:0012261)2.03547564
65Congenital hepatic fibrosis (HP:0002612)2.01331440
66Focal seizures (HP:0007359)2.01322719
67Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00734110
68Abnormality of alanine metabolism (HP:0010916)2.00734110
69Hyperalaninemia (HP:0003348)2.00734110
70Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98521964
71Short 1st metacarpal (HP:0010034)1.98521964
72Decreased central vision (HP:0007663)1.97853441
73Postaxial foot polydactyly (HP:0001830)1.97610156
74Tubular atrophy (HP:0000092)1.96234780
75Hypothermia (HP:0002045)1.96107480
76Morphological abnormality of the middle ear (HP:0008609)1.94552252
77Calf muscle hypertrophy (HP:0008981)1.93302135
78Decreased circulating renin level (HP:0003351)1.89569352
79Acute encephalopathy (HP:0006846)1.88146802
80Supraventricular tachycardia (HP:0004755)1.86707047
81Ketosis (HP:0001946)1.86649869
82Protruding tongue (HP:0010808)1.86169821
83Abnormality of macular pigmentation (HP:0008002)1.85519251
84Abnormality of the phalanges of the 2nd finger (HP:0009541)1.83236814
85Increased CSF lactate (HP:0002490)1.83228350
86Dialeptic seizures (HP:0011146)1.81692474
87Mitochondrial inheritance (HP:0001427)1.80740898
88Cerebellar dysplasia (HP:0007033)1.79350135
89Abnormality of the renal collecting system (HP:0004742)1.79253049
90Stenosis of the external auditory canal (HP:0000402)1.78994548
91Supraventricular arrhythmia (HP:0005115)1.78435470
92Bile duct proliferation (HP:0001408)1.77026174
93Abnormal biliary tract physiology (HP:0012439)1.77026174
94Abnormal mitochondria in muscle tissue (HP:0008316)1.76154146
95Muscle hypertrophy of the lower extremities (HP:0008968)1.74909604
96Congenital, generalized hypertrichosis (HP:0004540)1.74330586
97Anencephaly (HP:0002323)1.73984777
98Postaxial hand polydactyly (HP:0001162)1.73645336
99Optic disc pallor (HP:0000543)1.71139241
100Polyuria (HP:0000103)1.70876122

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.16105147
2MAP4K23.13837310
3BMPR1B2.87669757
4CASK2.69953986
5ACVR1B2.47174934
6INSRR2.46502757
7PINK12.42434208
8GRK12.33278327
9ADRBK22.25418824
10OBSCN2.25162337
11WNK32.19032863
12TAOK31.92806700
13STK38L1.84944202
14NUAK11.81500863
15MAPK131.69986195
16MUSK1.56450290
17TNIK1.49715100
18BCKDK1.39795829
19ZAK1.38374116
20GRK71.36185098
21MAP3K121.31394636
22MAP3K41.24635157
23PLK21.21346704
24TAF11.20707627
25PRKCE1.17304375
26TIE11.16116851
27OXSR11.14821795
28LATS11.12890285
29FLT31.10579943
30MKNK21.10531207
31MARK11.06048607
32PHKG11.05573687
33PHKG21.05573687
34STK391.04908851
35TXK1.03677265
36STK30.95108085
37ADRBK10.94469793
38PIK3CG0.93761984
39TEC0.93248146
40STK240.90641742
41MYLK0.89316778
42KIT0.86821280
43EIF2AK30.86624523
44PAK30.84979703
45CAMK2A0.84921992
46DAPK20.84719046
47NTRK30.77745796
48VRK10.77402010
49PRKCG0.75935314
50PLK40.75417728
51MAP2K70.73520742
52NEK10.72789958
53TGFBR10.69727155
54PKN10.69302105
55FER0.69166764
56WNK40.68898048
57NTRK20.68614575
58NLK0.65770923
59CAMKK20.64921085
60EPHA40.64821087
61PNCK0.62120973
62PRKACA0.60201998
63MAP3K70.59409358
64PIK3CA0.58984081
65EPHA30.57492213
66PDK20.57408190
67DYRK20.56935922
68ITK0.56735056
69CSNK1G20.54649236
70CAMK10.53438786
71CSNK1G10.53265312
72PTK2B0.53137658
73STK160.52900024
74ERBB30.52507215
75SGK20.52213170
76CAMK2D0.49575829
77FGFR20.48933319
78DYRK30.48848027
79PRKCQ0.48184620
80CAMK40.47042890
81STK110.46791253
82MAP2K40.46370749
83BCR0.46220937
84PRKG10.45831174
85PRKAA20.43665425
86MKNK10.41451278
87STK380.40962093
88PRKG20.40674428
89GRK50.40521235
90MST40.40179575
91CDK190.40161763
92CSNK1A1L0.38404414
93CSNK1G30.37656360
94VRK20.37219498
95IKBKB0.36842481
96NEK20.36730008
97PRKACB0.34244171
98PRKAA10.34140080
99CSNK1A10.34045930
100SGK10.33894127

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.57818088
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57121479
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.55806358
4Phototransduction_Homo sapiens_hsa047442.38564838
5Butanoate metabolism_Homo sapiens_hsa006502.36620066
6Nicotine addiction_Homo sapiens_hsa050332.26538841
7Linoleic acid metabolism_Homo sapiens_hsa005912.14387616
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.03648885
9Tryptophan metabolism_Homo sapiens_hsa003802.02570395
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91646796
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.91431722
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88966150
13Nitrogen metabolism_Homo sapiens_hsa009101.87413477
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.76534610
15Taste transduction_Homo sapiens_hsa047421.74692337
16Olfactory transduction_Homo sapiens_hsa047401.65521946
17Ether lipid metabolism_Homo sapiens_hsa005651.60959603
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60689572
19Oxidative phosphorylation_Homo sapiens_hsa001901.58912952
20Propanoate metabolism_Homo sapiens_hsa006401.58856092
21Morphine addiction_Homo sapiens_hsa050321.55818831
22Circadian entrainment_Homo sapiens_hsa047131.54282169
23ABC transporters_Homo sapiens_hsa020101.52256027
24Cardiac muscle contraction_Homo sapiens_hsa042601.51983957
25Sulfur metabolism_Homo sapiens_hsa009201.51891623
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.49453399
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48522916
28Selenocompound metabolism_Homo sapiens_hsa004501.46677510
29Insulin secretion_Homo sapiens_hsa049111.39675627
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.32216070
31Chemical carcinogenesis_Homo sapiens_hsa052041.31596588
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.30900709
33Retinol metabolism_Homo sapiens_hsa008301.30690123
34Basal transcription factors_Homo sapiens_hsa030221.29918993
35GABAergic synapse_Homo sapiens_hsa047271.29578544
36Peroxisome_Homo sapiens_hsa041461.26044192
37Salivary secretion_Homo sapiens_hsa049701.24975163
38Parkinsons disease_Homo sapiens_hsa050121.22947033
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22555965
40Glutamatergic synapse_Homo sapiens_hsa047241.19280283
41Calcium signaling pathway_Homo sapiens_hsa040201.19087045
42Renin secretion_Homo sapiens_hsa049241.13486282
43Regulation of autophagy_Homo sapiens_hsa041401.12235038
44Protein export_Homo sapiens_hsa030601.11898132
45RNA degradation_Homo sapiens_hsa030181.11848872
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09054544
47Serotonergic synapse_Homo sapiens_hsa047261.06331453
48Homologous recombination_Homo sapiens_hsa034401.05642511
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02803798
50Arachidonic acid metabolism_Homo sapiens_hsa005901.01036798
51Dorso-ventral axis formation_Homo sapiens_hsa043200.99153557
52Glycerolipid metabolism_Homo sapiens_hsa005610.97682967
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97515072
54Caffeine metabolism_Homo sapiens_hsa002320.96907806
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96261973
56beta-Alanine metabolism_Homo sapiens_hsa004100.95989322
57Fatty acid degradation_Homo sapiens_hsa000710.94122480
58Fanconi anemia pathway_Homo sapiens_hsa034600.93668866
59Alzheimers disease_Homo sapiens_hsa050100.91716435
60Ovarian steroidogenesis_Homo sapiens_hsa049130.87642654
61RNA polymerase_Homo sapiens_hsa030200.87366280
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85097813
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.85000109
64Dilated cardiomyopathy_Homo sapiens_hsa054140.83426671
65Huntingtons disease_Homo sapiens_hsa050160.83224561
66Histidine metabolism_Homo sapiens_hsa003400.83217396
67Pancreatic secretion_Homo sapiens_hsa049720.78751991
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77763571
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77648539
70Circadian rhythm_Homo sapiens_hsa047100.77282036
71One carbon pool by folate_Homo sapiens_hsa006700.70371918
72Collecting duct acid secretion_Homo sapiens_hsa049660.68514423
73Fat digestion and absorption_Homo sapiens_hsa049750.67943103
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.65808786
75TGF-beta signaling pathway_Homo sapiens_hsa043500.65504906
76Purine metabolism_Homo sapiens_hsa002300.64569122
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61919528
78Metabolic pathways_Homo sapiens_hsa011000.58076452
79Oxytocin signaling pathway_Homo sapiens_hsa049210.57997043
80cAMP signaling pathway_Homo sapiens_hsa040240.57852991
81Gastric acid secretion_Homo sapiens_hsa049710.57832910
82Fatty acid metabolism_Homo sapiens_hsa012120.57440183
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56290441
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54676673
85Type II diabetes mellitus_Homo sapiens_hsa049300.53995428
86Cholinergic synapse_Homo sapiens_hsa047250.53992361
87Asthma_Homo sapiens_hsa053100.53782029
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53290808
89Dopaminergic synapse_Homo sapiens_hsa047280.51540287
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51480257
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51059361
92Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50234455
93Amphetamine addiction_Homo sapiens_hsa050310.50078754
94Starch and sucrose metabolism_Homo sapiens_hsa005000.49376184
95PPAR signaling pathway_Homo sapiens_hsa033200.43747751
96Pyruvate metabolism_Homo sapiens_hsa006200.43550051
97Mineral absorption_Homo sapiens_hsa049780.42681257
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41540333
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41352588
100Long-term depression_Homo sapiens_hsa047300.39608276

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