FPGS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.02988696
2L-phenylalanine catabolic process (GO:0006559)7.02988696
3L-phenylalanine metabolic process (GO:0006558)6.90806690
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.90806690
5aromatic amino acid family catabolic process (GO:0009074)6.38203321
6indole-containing compound catabolic process (GO:0042436)5.86850657
7indolalkylamine catabolic process (GO:0046218)5.86850657
8tryptophan catabolic process (GO:0006569)5.86850657
9kynurenine metabolic process (GO:0070189)5.81282645
10cysteine metabolic process (GO:0006534)5.71886801
11glyoxylate metabolic process (GO:0046487)5.62961098
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.60788876
13tryptophan metabolic process (GO:0006568)5.51206100
14bile acid biosynthetic process (GO:0006699)5.48827620
15serine family amino acid catabolic process (GO:0009071)5.48523026
16sulfur amino acid catabolic process (GO:0000098)5.37310859
17urea metabolic process (GO:0019627)5.31033106
18urea cycle (GO:0000050)5.31033106
19glycine metabolic process (GO:0006544)5.28905292
20negative regulation of fibrinolysis (GO:0051918)5.27678422
21alpha-linolenic acid metabolic process (GO:0036109)5.06573455
22regulation of fibrinolysis (GO:0051917)4.98695284
23high-density lipoprotein particle remodeling (GO:0034375)4.93405750
24regulation of protein activation cascade (GO:2000257)4.91106770
25nitrogen cycle metabolic process (GO:0071941)4.89703926
26peptidyl-glutamic acid carboxylation (GO:0017187)4.88652235
27protein carboxylation (GO:0018214)4.88652235
28lysine catabolic process (GO:0006554)4.83943620
29lysine metabolic process (GO:0006553)4.83943620
30serine family amino acid metabolic process (GO:0009069)4.81788961
31serine family amino acid biosynthetic process (GO:0009070)4.81552365
32complement activation, alternative pathway (GO:0006957)4.75149537
33homocysteine metabolic process (GO:0050667)4.74228765
34aromatic amino acid family metabolic process (GO:0009072)4.71680159
35bile acid metabolic process (GO:0008206)4.65450821
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.65210835
37regulation of complement activation (GO:0030449)4.57388670
38amino-acid betaine metabolic process (GO:0006577)4.54720719
39alpha-amino acid catabolic process (GO:1901606)4.51069071
40imidazole-containing compound metabolic process (GO:0052803)4.38446096
41negative regulation of sterol transport (GO:0032372)4.26938109
42negative regulation of cholesterol transport (GO:0032375)4.26938109
43regulation of triglyceride catabolic process (GO:0010896)4.26451165
44tyrosine metabolic process (GO:0006570)4.24029242
45acylglycerol homeostasis (GO:0055090)4.20242490
46triglyceride homeostasis (GO:0070328)4.20242490
47reverse cholesterol transport (GO:0043691)4.19519966
48cellular amino acid catabolic process (GO:0009063)4.17449704
49regulation of cholesterol esterification (GO:0010872)4.16410770
50macromolecular complex remodeling (GO:0034367)4.16392026
51plasma lipoprotein particle remodeling (GO:0034369)4.16392026
52protein-lipid complex remodeling (GO:0034368)4.16392026
53indolalkylamine metabolic process (GO:0006586)4.08304389
54cellular modified amino acid catabolic process (GO:0042219)4.03744307
55ethanol oxidation (GO:0006069)4.03542126
56coenzyme catabolic process (GO:0009109)4.02136202
57bile acid and bile salt transport (GO:0015721)4.02060412
58cellular biogenic amine catabolic process (GO:0042402)3.99927955
59amine catabolic process (GO:0009310)3.99927955
60negative regulation of erythrocyte differentiation (GO:0045647)3.98309846
61cellular ketone body metabolic process (GO:0046950)3.97782192
62glutamate metabolic process (GO:0006536)3.90834538
63L-serine metabolic process (GO:0006563)3.90077969
64NIK/NF-kappaB signaling (GO:0038061)3.89530282
65phospholipid efflux (GO:0033700)3.86817825
66benzene-containing compound metabolic process (GO:0042537)3.82852829
67plasma lipoprotein particle clearance (GO:0034381)3.81725962
68arginine metabolic process (GO:0006525)3.69237479
69urate metabolic process (GO:0046415)3.67614269
70fibrinolysis (GO:0042730)3.67406164
71blood coagulation, intrinsic pathway (GO:0007597)3.67217989
72regulation of cholesterol homeostasis (GO:2000188)3.65363992
73aldehyde catabolic process (GO:0046185)3.65327478
74response to peptidoglycan (GO:0032494)3.62885715
75drug catabolic process (GO:0042737)3.61768548
76cellular glucuronidation (GO:0052695)3.61586415
77organic acid catabolic process (GO:0016054)3.58545990
78carboxylic acid catabolic process (GO:0046395)3.58545990
79positive regulation of gamma-delta T cell activation (GO:0046645)3.57587875
80* one-carbon metabolic process (GO:0006730)3.56934503
81dicarboxylic acid biosynthetic process (GO:0043650)3.54073389
82positive regulation of lipoprotein lipase activity (GO:0051006)3.53512037
83positive regulation of triglyceride lipase activity (GO:0061365)3.53512037
84plasma lipoprotein particle assembly (GO:0034377)3.51933551
852-oxoglutarate metabolic process (GO:0006103)3.51563280
86complement activation, classical pathway (GO:0006958)3.50941159
87acetyl-CoA metabolic process (GO:0006084)3.49845022
88cholesterol efflux (GO:0033344)3.49522046
89response to nitrosative stress (GO:0051409)3.46469847
90negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.45137011
91aspartate family amino acid catabolic process (GO:0009068)3.44150741
92heme transport (GO:0015886)3.42910882
93pyridine nucleotide biosynthetic process (GO:0019363)3.42258328
94nicotinamide nucleotide biosynthetic process (GO:0019359)3.42258328
95ketone body metabolic process (GO:1902224)3.41557536
96cofactor catabolic process (GO:0051187)3.40944831
97regulation of vitamin D biosynthetic process (GO:0060556)3.40457432
98cholesterol homeostasis (GO:0042632)3.39349416
99negative regulation of fatty acid biosynthetic process (GO:0045717)3.39193834
100complement activation (GO:0006956)3.38980483
101pinocytosis (GO:0006907)3.37561313
102protein activation cascade (GO:0072376)3.35905936
103NAD biosynthetic process (GO:0009435)3.35835969
104sterol homeostasis (GO:0055092)3.34333698
105cytolysis (GO:0019835)3.32945458
106drug transmembrane transport (GO:0006855)3.30629725
107low-density lipoprotein particle remodeling (GO:0034374)3.30186398
108mature B cell differentiation involved in immune response (GO:0002313)3.25172438
109purine nucleotide salvage (GO:0032261)3.19429383
110negative regulation of myeloid cell apoptotic process (GO:0033033)3.13655012
111response to muramyl dipeptide (GO:0032495)3.11365522
112pentose-phosphate shunt (GO:0006098)3.09562408
113nucleotide salvage (GO:0043173)3.08300832
114immunoglobulin mediated immune response (GO:0016064)3.07335511
115regulation of type I interferon-mediated signaling pathway (GO:0060338)3.05556304
116activation of MAPKKK activity (GO:0000185)3.02094591
117regulation of T-helper 1 cell differentiation (GO:0045625)3.01220735
118lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95459023
119deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94761890
120negative regulation of interleukin-12 production (GO:0032695)2.90765955
121regulation of vitamin metabolic process (GO:0030656)2.88005816
122cellular response to type I interferon (GO:0071357)2.84593780
123type I interferon signaling pathway (GO:0060337)2.84593780
124regulation of chemokine biosynthetic process (GO:0045073)2.82998800
125response to type I interferon (GO:0034340)2.82326354
126purine deoxyribonucleotide catabolic process (GO:0009155)2.81802072
127negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80134093
128modulation by symbiont of host cellular process (GO:0044068)2.78731685
129positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.78081111
130positive regulation of B cell differentiation (GO:0045579)2.77402089
131barbed-end actin filament capping (GO:0051016)2.75996735
132negative regulation of B cell apoptotic process (GO:0002903)2.74217126
133mucosal-associated lymphoid tissue development (GO:0048537)2.72391819
134Peyers patch development (GO:0048541)2.72391819
135positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.72106499
136germinal center formation (GO:0002467)2.69721474
137antigen processing and presentation of endogenous antigen (GO:0019883)2.68345890
138mannose metabolic process (GO:0006013)2.68136062
139chaperone mediated protein folding requiring cofactor (GO:0051085)2.66619643
140UV protection (GO:0009650)2.65113800
141Golgi transport vesicle coating (GO:0048200)2.63275731
142COPI coating of Golgi vesicle (GO:0048205)2.63275731
143negative regulation of cell size (GO:0045792)2.62989605
144regulation of monocyte differentiation (GO:0045655)2.62078645
145response to protozoan (GO:0001562)2.61102046
146antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.60789364
147regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59086978
148antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.58166515
149positive thymic T cell selection (GO:0045059)2.55793934
150NADPH regeneration (GO:0006740)2.54417471
151glucose catabolic process (GO:0006007)2.54178102
152positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49658989
153GDP-mannose metabolic process (GO:0019673)2.49261289
154myeloid dendritic cell differentiation (GO:0043011)2.48067734
155cellular response to virus (GO:0098586)2.47324633
156positive regulation of chemokine biosynthetic process (GO:0045080)2.45857244
157glycosphingolipid catabolic process (GO:0046479)2.45393653
158negative regulation of innate immune response (GO:0045824)2.44926034
159regulation of gamma-delta T cell activation (GO:0046643)2.44548331
160negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43935380
161regulation of B cell apoptotic process (GO:0002902)2.43458354
162positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43344228
163regulation of necrotic cell death (GO:0010939)2.42914888
164negative regulation of tumor necrosis factor production (GO:0032720)2.41849540
165defense response to protozoan (GO:0042832)2.41121006
166low-density lipoprotein particle clearance (GO:0034383)2.40470666
167regulation of interleukin-2 biosynthetic process (GO:0045076)2.39107413
168myeloid dendritic cell activation (GO:0001773)2.38036008
169protein localization to endosome (GO:0036010)2.37467573
170positive regulation of natural killer cell differentiation (GO:0032825)2.37154295
1713-UTR-mediated mRNA stabilization (GO:0070935)2.36983872
172regulation of superoxide anion generation (GO:0032928)2.36384131
173tumor necrosis factor-mediated signaling pathway (GO:0033209)2.35811981
174negative regulation of necroptotic process (GO:0060546)2.35047634
175regulation of dendritic cell antigen processing and presentation (GO:0002604)2.34248394
176modulation by virus of host process (GO:0019054)2.33989788
177amino sugar catabolic process (GO:0046348)2.33646627
178negative regulation of cell killing (GO:0031342)2.33429511
179negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33429511
180protein retention in ER lumen (GO:0006621)2.32978950
181negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.32788275
182negative regulation of cytokine production involved in immune response (GO:0002719)2.32732996
183regulation of cholesterol storage (GO:0010885)2.32677808
184pyrimidine-containing compound salvage (GO:0008655)2.31171132
185pyrimidine nucleoside salvage (GO:0043097)2.31171132
186regulation of gamma-delta T cell differentiation (GO:0045586)2.29247885
187positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27652907
188neutrophil activation involved in immune response (GO:0002283)2.27160478
189B cell mediated immunity (GO:0019724)2.26790265
190epithelial cell differentiation involved in prostate gland development (GO:0060742)2.25253083
191regulation of antigen processing and presentation (GO:0002577)2.24799980
192positive regulation of Cdc42 GTPase activity (GO:0043089)2.24621411
193maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.23834561
194Arp2/3 complex-mediated actin nucleation (GO:0034314)2.23608938
195CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.23497928
196pentose metabolic process (GO:0019321)2.22450228
197regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.21574960
198response to thyroid hormone (GO:0097066)2.21085659
199negative regulation of type I interferon production (GO:0032480)2.20969989
200regulation of podosome assembly (GO:0071801)2.20787571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.60464078
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.62055978
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.88002967
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.42748149
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.85289714
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45189546
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01507313
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.83604717
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.73689096
10VDR_21846776_ChIP-Seq_THP-1_Human3.03096576
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.79220907
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.65663775
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.45715185
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.27877119
15E2F7_22180533_ChIP-Seq_HELA_Human2.27022909
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.25142439
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.22466415
18* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12553213
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.01153287
20* MYC_18555785_ChIP-Seq_MESCs_Mouse1.94022836
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93236527
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.89205249
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87696869
24VDR_24763502_ChIP-Seq_THP-1_Human1.83205320
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74666214
26MAF_26560356_Chip-Seq_TH1_Human1.73904253
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73232875
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73127725
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72668832
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67088050
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62032194
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61577074
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56762178
34TCF7_22412390_ChIP-Seq_EML_Mouse1.56725938
35KDM2B_26808549_Chip-Seq_DND41_Human1.54748486
36* UTX_26944678_Chip-Seq_JUKART_Human1.53670007
37MAF_26560356_Chip-Seq_TH2_Human1.53335434
38AR_21909140_ChIP-Seq_LNCAP_Human1.53308391
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50986797
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50036466
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49680037
42TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.48250615
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48150301
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46970096
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44046045
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.43905131
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43262392
48CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41991655
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40352572
50ELF1_20517297_ChIP-Seq_JURKAT_Human1.39651052
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.38838144
52CLOCK_20551151_ChIP-Seq_293T_Human1.37702227
53* P68_20966046_ChIP-Seq_HELA_Human1.37340789
54SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34967274
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.31746128
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30116560
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29773929
58ZNF263_19887448_ChIP-Seq_K562_Human1.29623673
59CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29296125
60* SA1_27219007_Chip-Seq_ERYTHROID_Human1.29237698
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29122327
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.28772104
63BCL6_27268052_Chip-Seq_Bcells_Human1.28186993
64CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27842513
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27749461
66* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.27523032
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26102127
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26008744
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25115987
70NCOR1_26117541_ChIP-Seq_K562_Human1.23341283
71SPI1_23547873_ChIP-Seq_NB4_Human1.23248875
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22746730
73SCL_19346495_ChIP-Seq_HPC-7_Human1.21967226
74MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20854330
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20400796
76* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19694207
77TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19289907
78* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18771360
79MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18161871
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17492831
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16859375
82* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15620879
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14910139
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13980896
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.13889229
86HNF4A_19822575_ChIP-Seq_HepG2_Human1.12528827
87SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12277697
88* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12071364
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10626171
90NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10518224
91* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09843132
92GATA1_22025678_ChIP-Seq_K562_Human1.09226940
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08552509
94* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06087515
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05415893
96* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.05340520
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04524579
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.03982374
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03764162
100* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02903980
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00932425
102* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00543501
103CTCF_21964334_Chip-Seq_Bcells_Human1.00432013
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00176099
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.99087005
106DCP1A_22483619_ChIP-Seq_HELA_Human0.98796762
107* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97862126
108* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97527803
109XRN2_22483619_ChIP-Seq_HELA_Human0.97338780
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97217939
111MYC_22102868_ChIP-Seq_BL_Human0.93355049
112GABP_19822575_ChIP-Seq_HepG2_Human0.93070751
113MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91904473
114EST1_17652178_ChIP-ChIP_JURKAT_Human0.91871726
115FOXA2_19822575_ChIP-Seq_HepG2_Human0.91762077
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.90750696
117KDM5A_27292631_Chip-Seq_BREAST_Human0.90162544
118NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.88770702
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88431776
120NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88327422
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88189805
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88061868
123RARA_24833708_ChIP-Seq_LIVER_Mouse0.87212310
124KAP1_22055183_ChIP-Seq_ESCs_Mouse0.85266670
125POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84879223
126ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84566292
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.84062125
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81628497
129RARB_24833708_ChIP-Seq_LIVER_Mouse0.80523988
130FOXP3_21729870_ChIP-Seq_TREG_Human0.79177106
131PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79063572
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78134798
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76291251
134E2F4_17652178_ChIP-ChIP_JURKAT_Human0.75579425
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75265899
136SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74619552
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.73258485
138HTT_18923047_ChIP-ChIP_STHdh_Human0.72215931
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70649181
140E2F1_21310950_ChIP-Seq_MCF-7_Human0.69791307
141* GATA4_25053715_ChIP-Seq_YYC3_Human0.69618579
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.69526361
143* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.68974773
144* ATF3_27146783_Chip-Seq_COLON_Human0.68371491
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.68244569
146GATA6_25053715_ChIP-Seq_YYC3_Human0.65708502
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.65120249
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.64904811
149SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.64776336
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.63469009
151SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.62805007
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61962891
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61595639
154GATA1_22383799_ChIP-Seq_G1ME_Mouse0.61470919
155VDR_23849224_ChIP-Seq_CD4+_Human0.61300402
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.59407048
157CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.59219129
158* TET1_21451524_ChIP-Seq_MESCs_Mouse0.58521441
159LXR_22292898_ChIP-Seq_THP-1_Human0.58480550
160TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.58113256
161BCOR_27268052_Chip-Seq_Bcells_Human0.57809354
162KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.56964187
163FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.55033270
164* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.54755160
165RACK7_27058665_Chip-Seq_MCF-7_Human0.54659304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.68965305
2MP0005360_urolithiasis7.03171183
3MP0005085_abnormal_gallbladder_physiolo5.92424033
4MP0005365_abnormal_bile_salt5.83394353
5MP0003806_abnormal_nucleotide_metabolis4.77592528
6MP0008875_abnormal_xenobiotic_pharmacok4.49816476
7MP0003252_abnormal_bile_duct3.57392414
8MP0003303_peritoneal_inflammation3.38643703
9MP0009840_abnormal_foam_cell3.31368584
10MP0005058_abnormal_lysosome_morphology3.29017261
11MP0010329_abnormal_lipoprotein_level3.16659725
12MP0005083_abnormal_biliary_tract2.92775319
13MP0009278_abnormal_bone_marrow2.72135940
14MP0005332_abnormal_amino_acid2.69686269
15MP0001835_abnormal_antigen_presentation2.51835360
16MP0001666_abnormal_nutrient_absorption2.49506346
17MP0002148_abnormal_hypersensitivity_rea2.39327496
18MP0003195_calcinosis2.38423793
19MP0005000_abnormal_immune_tolerance2.23794218
20MP0003191_abnormal_cellular_cholesterol2.14689104
21MP0000609_abnormal_liver_physiology2.14326290
22MP0001545_abnormal_hematopoietic_system2.12917305
23MP0005025_abnormal_response_to2.12569775
24MP0009785_altered_susceptibility_to2.10710864
25MP0000685_abnormal_immune_system2.03087406
26MP0009333_abnormal_splenocyte_physiolog2.03081488
27MP0004019_abnormal_vitamin_homeostasis2.01117848
28MP0004510_myositis2.01095640
29MP0005387_immune_system_phenotype1.96677584
30MP0001790_abnormal_immune_system1.96677584
31MP0003300_gastrointestinal_ulcer1.95396656
32MP0002419_abnormal_innate_immunity1.94871306
33MP0003763_abnormal_thymus_physiology1.93425457
34MP0004947_skin_inflammation1.90127880
35MP0005319_abnormal_enzyme/_coenzyme1.83517819
36MP0005451_abnormal_body_composition1.82917766
37MP0002118_abnormal_lipid_homeostasis1.82207805
38MP0002723_abnormal_immune_serum1.80170341
39MP0002138_abnormal_hepatobiliary_system1.79878633
40MP0002452_abnormal_antigen_presenting1.78459341
41MP0003724_increased_susceptibility_to1.78029308
42MP0005671_abnormal_response_to1.78019277
43MP0000858_altered_metastatic_potential1.78015649
44MP0003868_abnormal_feces_composition1.74255396
45MP0001800_abnormal_humoral_immune1.70952205
46MP0003705_abnormal_hypodermis_morpholog1.70935282
47MP0001764_abnormal_homeostasis1.69293402
48MP0001819_abnormal_immune_cell1.65135952
49MP0002420_abnormal_adaptive_immunity1.64707190
50MP0001533_abnormal_skeleton_physiology1.63835654
51MP0003186_abnormal_redox_activity1.55715463
52MP0003075_altered_response_to1.51716987
53MP0006082_CNS_inflammation1.51343069
54MP0004185_abnormal_adipocyte_glucose1.50554979
55MP0003172_abnormal_lysosome_physiology1.46717371
56MP0001849_ear_inflammation1.45767339
57MP0002398_abnormal_bone_marrow1.45721473
58MP0008260_abnormal_autophagy1.45124158
59MP0003656_abnormal_erythrocyte_physiolo1.45118687
60MP0010155_abnormal_intestine_physiology1.43429098
61MP0003718_maternal_effect1.38878379
62MP0000343_altered_response_to1.37853425
63MP0000716_abnormal_immune_system1.37119650
64MP0002877_abnormal_melanocyte_morpholog1.36822717
65MP0002405_respiratory_system_inflammati1.35227594
66MP0005076_abnormal_cell_differentiation1.35017047
67MP0009643_abnormal_urine_homeostasis1.34712831
68MP0001845_abnormal_inflammatory_respons1.33878498
69MP0005584_abnormal_enzyme/coenzyme_acti1.32463491
70MP0002722_abnormal_immune_system1.32135379
71MP0000598_abnormal_liver_morphology1.31932965
72MP0009697_abnormal_copulation1.31259487
73MP0004808_abnormal_hematopoietic_stem1.29423387
74MP0002429_abnormal_blood_cell1.27284456
75MP0001873_stomach_inflammation1.25212811
76MP0002396_abnormal_hematopoietic_system1.22400193
77MP0000689_abnormal_spleen_morphology1.19670390
78MP0005647_abnormal_sex_gland1.15086318
79MP0003011_delayed_dark_adaptation1.14835824
80MP0000465_gastrointestinal_hemorrhage1.14783722
81MP0003448_altered_tumor_morphology1.14269440
82MP0002998_abnormal_bone_remodeling1.12291376
83MP0002933_joint_inflammation1.08430545
84MP0000490_abnormal_crypts_of1.06396556
85MP0003279_aneurysm1.05577852
86MP0006036_abnormal_mitochondrial_physio1.04638508
87MP0005220_abnormal_exocrine_pancreas1.04090004
88MP0002332_abnormal_exercise_endurance1.03895625
89MP0005375_adipose_tissue_phenotype1.02911877
90MP0000703_abnormal_thymus_morphology1.01661591
91MP0004858_abnormal_nervous_system1.00971183
92MP0005636_abnormal_mineral_homeostasis0.99044609
93MP0005165_increased_susceptibility_to0.98209943
94MP0009763_increased_sensitivity_to0.98143840
95MP0005166_decreased_susceptibility_to0.96532772
96MP0003091_abnormal_cell_migration0.95235469
97MP0008438_abnormal_cutaneous_collagen0.94796593
98MP0003693_abnormal_embryo_hatching0.94222988
99MP0005390_skeleton_phenotype0.93425786
100MP0005408_hypopigmentation0.93116861
101MP0003566_abnormal_cell_adhesion0.92607608
102MP0010368_abnormal_lymphatic_system0.87961367
103MP0000750_abnormal_muscle_regeneration0.83195943
104MP0008469_abnormal_protein_level0.81414414
105MP0005395_other_phenotype0.81287258
106MP0000003_abnormal_adipose_tissue0.80102418
107MP0005310_abnormal_salivary_gland0.80066358
108MP0009642_abnormal_blood_homeostasis0.78965129
109MP0009764_decreased_sensitivity_to0.78716897
110MP0005670_abnormal_white_adipose0.78713189
111MP0005376_homeostasis/metabolism_phenot0.78588191
112MP0005266_abnormal_metabolism0.78046873
113MP0009053_abnormal_anal_canal0.77000066
114MP0001542_abnormal_bone_strength0.76243977
115MP0006035_abnormal_mitochondrial_morpho0.74744229
116MP0004264_abnormal_extraembryonic_tissu0.73591053
117MP0009765_abnormal_xenobiotic_induced0.73451626
118MP0005084_abnormal_gallbladder_morpholo0.72865779
119MP0008007_abnormal_cellular_replicative0.72151111
120MP0005621_abnormal_cell_physiology0.71899281
121MP0004233_abnormal_muscle_weight0.71148586
122MP0009931_abnormal_skin_appearance0.70701831
123MP0003795_abnormal_bone_structure0.70364060
124MP0003329_amyloid_beta_deposits0.69640148
125MP0001756_abnormal_urination0.68007806
126MP0002254_reproductive_system_inflammat0.67429993
127MP0004957_abnormal_blastocyst_morpholog0.66720093
128MP0009672_abnormal_birth_weight0.64923243
129MP0002078_abnormal_glucose_homeostasis0.62566887
130MP0000604_amyloidosis0.61480765
131MP0001661_extended_life_span0.60961820
132MP0003111_abnormal_nucleus_morphology0.57034658
133MP0002136_abnormal_kidney_physiology0.55980217
134MP0005334_abnormal_fat_pad0.52769288
135MP0005023_abnormal_wound_healing0.52251632
136MP0002132_abnormal_respiratory_system0.52245336
137MP0001915_intracranial_hemorrhage0.50917708
138MP0008873_increased_physiological_sensi0.50818247
139MP0002971_abnormal_brown_adipose0.50624174
140MP0003699_abnormal_female_reproductive0.48538912
141MP0001730_embryonic_growth_arrest0.48460738
142MP0000639_abnormal_adrenal_gland0.48438282
143MP0010094_abnormal_chromosome_stability0.45919247
144MP0002796_impaired_skin_barrier0.44798879
145MP0005464_abnormal_platelet_physiology0.44608625
146MP0001243_abnormal_dermal_layer0.44128646
147MP0003077_abnormal_cell_cycle0.43677579
148MP0002970_abnormal_white_adipose0.42708853
149MP0010352_gastrointestinal_tract_polyps0.40283472
150MP0005666_abnormal_adipose_tissue0.38726441
151MP0001119_abnormal_female_reproductive0.38533258
152MP0003436_decreased_susceptibility_to0.38476775
153MP0002928_abnormal_bile_duct0.37558619
154MP0010234_abnormal_vibrissa_follicle0.37456415
155MP0003638_abnormal_response/metabolism_0.35935147
156MP0002269_muscular_atrophy0.35388998
157MP0001853_heart_inflammation0.35185014
158MP0002135_abnormal_kidney_morphology0.34575954
159MP0005075_abnormal_melanosome_morpholog0.34166329
160MP0002060_abnormal_skin_morphology0.33910935
161MP0002019_abnormal_tumor_incidence0.33365994
162MP0002086_abnormal_extraembryonic_tissu0.32727027
163MP0005380_embryogenesis_phenotype0.32572137
164MP0001672_abnormal_embryogenesis/_devel0.32572137
165MP0005448_abnormal_energy_balance0.31894793
166MP0003453_abnormal_keratinocyte_physiol0.31835521
167MP0000579_abnormal_nail_morphology0.31822278
168MP0009115_abnormal_fat_cell0.31571826
169MP0000358_abnormal_cell_content/0.31560349
170MP0001881_abnormal_mammary_gland0.30867215
171MP0003953_abnormal_hormone_level0.30618608
172MP0005501_abnormal_skin_physiology0.29957071
173MP0005397_hematopoietic_system_phenotyp0.29765995

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.19600846
2Intrahepatic cholestasis (HP:0001406)7.12847366
3Deep venous thrombosis (HP:0002625)7.04531647
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63123062
5Hypobetalipoproteinemia (HP:0003563)6.22430948
6Prolonged partial thromboplastin time (HP:0003645)5.86338068
7Xanthomatosis (HP:0000991)5.83249736
8Hyperlipoproteinemia (HP:0010980)4.94201100
9Hyperglycinemia (HP:0002154)4.79696062
10Complement deficiency (HP:0004431)4.74772043
11Hyperammonemia (HP:0001987)4.68250270
12Hypolipoproteinemia (HP:0010981)4.55391287
13Abnormality of sulfur amino acid metabolism (HP:0004339)4.47321317
14Abnormality of pyrimidine metabolism (HP:0004353)4.37506811
15Hyperglycinuria (HP:0003108)4.31571729
16Abnormality of methionine metabolism (HP:0010901)4.26170062
17Joint hemorrhage (HP:0005261)4.18781162
18Abnormality of glycine metabolism (HP:0010895)4.17452652
19Abnormality of serine family amino acid metabolism (HP:0010894)4.17452652
20Abnormality of the common coagulation pathway (HP:0010990)4.16678797
21Abnormality of glycolipid metabolism (HP:0010969)4.13428929
22Abnormality of liposaccharide metabolism (HP:0010968)4.13428929
23Abnormality of glycosphingolipid metabolism (HP:0004343)4.13428929
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10386316
25Ketosis (HP:0001946)4.10044522
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.06069978
27Fat malabsorption (HP:0002630)3.96646192
28Epidermoid cyst (HP:0200040)3.95350871
29Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86204702
30Hypoalphalipoproteinemia (HP:0003233)3.85847020
31Abnormality of the intrinsic pathway (HP:0010989)3.85509221
32Hypoglycemic coma (HP:0001325)3.73925993
33Abnormality of complement system (HP:0005339)3.51777896
34Abnormality of serum amino acid levels (HP:0003112)3.37337673
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35768055
36Abnormality of fatty-acid metabolism (HP:0004359)3.34754552
37Abnormality of nucleobase metabolism (HP:0010932)3.32757474
38Hyperbilirubinemia (HP:0002904)3.30422176
39Delayed CNS myelination (HP:0002188)3.27341228
40Dysostosis multiplex (HP:0000943)3.27145830
41Loss of speech (HP:0002371)3.20604937
42Conjugated hyperbilirubinemia (HP:0002908)3.15645751
43Hypercholesterolemia (HP:0003124)3.12857913
44Steatorrhea (HP:0002570)3.05692552
45Ragged-red muscle fibers (HP:0003200)3.04511150
46Vertebral compression fractures (HP:0002953)3.00590768
47Increased cerebral lipofuscin (HP:0011813)2.95036292
48Hepatocellular carcinoma (HP:0001402)2.94765843
49Gout (HP:0001997)2.93985199
50Spastic diplegia (HP:0001264)2.90149248
51Hypochromic microcytic anemia (HP:0004840)2.84333681
52Ketoacidosis (HP:0001993)2.82663615
53Abnormality of purine metabolism (HP:0004352)2.80382806
54Spontaneous abortion (HP:0005268)2.78024838
55Myocardial infarction (HP:0001658)2.75987811
56Lethargy (HP:0001254)2.74043241
57Cellulitis (HP:0100658)2.73931284
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72568107
59Dicarboxylic aciduria (HP:0003215)2.72568107
60Metabolic acidosis (HP:0001942)2.68817171
61Malnutrition (HP:0004395)2.67104439
62Mediastinal lymphadenopathy (HP:0100721)2.63634739
63Eczematoid dermatitis (HP:0000976)2.63061711
64Elevated erythrocyte sedimentation rate (HP:0003565)2.62303911
65Abnormality of macrophages (HP:0004311)2.57355803
66Agammaglobulinemia (HP:0004432)2.54162023
67Recurrent viral infections (HP:0004429)2.54058884
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.53440616
69Centrally nucleated skeletal muscle fibers (HP:0003687)2.52364380
70Vacuolated lymphocytes (HP:0001922)2.50704657
71Hepatosplenomegaly (HP:0001433)2.50597712
72Hypertensive crisis (HP:0100735)2.50030355
73Petechiae (HP:0000967)2.49169458
74Myositis (HP:0100614)2.48662061
75Achilles tendon contracture (HP:0001771)2.47332195
76Interstitial pulmonary disease (HP:0006530)2.45910032
77Distal lower limb muscle weakness (HP:0009053)2.44176387
78Skin nodule (HP:0200036)2.39415970
79Acanthocytosis (HP:0001927)2.36979186
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.35535490
81Abnormality of polysaccharide metabolism (HP:0011012)2.35535490
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.35535490
83Autoimmune thrombocytopenia (HP:0001973)2.33917019
84Recurrent abscess formation (HP:0002722)2.32500601
85Neonatal onset (HP:0003623)2.32327372
86Irritability (HP:0000737)2.31967525
87Vascular calcification (HP:0004934)2.28082748
88Thoracic kyphosis (HP:0002942)2.27706641
89Nuclear cataract (HP:0100018)2.27421128
90Late onset (HP:0003584)2.27250613
91Brushfield spots (HP:0001088)2.27207639
92Polygenic inheritance (HP:0010982)2.26326544
93Mucopolysacchariduria (HP:0008155)2.26124099
94Urinary glycosaminoglycan excretion (HP:0003541)2.26124099
95Colitis (HP:0002583)2.24840672
96Cholecystitis (HP:0001082)2.22997678
97Abnormal gallbladder physiology (HP:0012438)2.22997678
98Recurrent bacterial skin infections (HP:0005406)2.22509313
99Distal lower limb amyotrophy (HP:0008944)2.22218746
100Progressive muscle weakness (HP:0003323)2.21883709
101Progressive neurologic deterioration (HP:0002344)2.20572767
102Cerebral edema (HP:0002181)2.19606928
103Abnormal cartilage morphology (HP:0002763)2.19535087
104Abnormal gallbladder morphology (HP:0012437)2.19325775
105Cholelithiasis (HP:0001081)2.18227520
106Abnormality of transition element cation homeostasis (HP:0011030)2.17389862
107Esophageal varix (HP:0002040)2.17004456
108Recurrent fungal infections (HP:0002841)2.16729729
109Increased IgM level (HP:0003496)2.16729720
110Hypoglycemic seizures (HP:0002173)2.15900144
111Increased IgE level (HP:0003212)2.15728658
112Abnormality of iron homeostasis (HP:0011031)2.15254372
113B lymphocytopenia (HP:0010976)2.14476842
114Gastrointestinal stroma tumor (HP:0100723)2.13010064
115Generalized aminoaciduria (HP:0002909)2.12464373
116Axonal loss (HP:0003447)2.11891411
117Orchitis (HP:0100796)2.10627227
118Pancreatitis (HP:0001733)2.09938675
119Prolonged neonatal jaundice (HP:0006579)2.08748683
120Systemic lupus erythematosus (HP:0002725)2.08668164
121Hypergammaglobulinemia (HP:0010702)2.08318947
122Asymmetric septal hypertrophy (HP:0001670)2.08204868
123Opisthotonus (HP:0002179)2.07796717
124Meningitis (HP:0001287)2.07308631
125Hypertriglyceridemia (HP:0002155)2.05670959
126Thrombophlebitis (HP:0004418)2.05644072
127Myopathic facies (HP:0002058)2.05610987
128Chronic obstructive pulmonary disease (HP:0006510)2.03885641
129Obstructive lung disease (HP:0006536)2.03885641
130Abnormality of the thoracic spine (HP:0100711)2.03195664
131Cardiovascular calcification (HP:0011915)1.99572295
132Rough bone trabeculation (HP:0100670)1.98839939
133Purpura (HP:0000979)1.98662292
134Vomiting (HP:0002013)1.98236462
135Poikilocytosis (HP:0004447)1.97216794
136Protrusio acetabuli (HP:0003179)1.96867338
137Bulbar palsy (HP:0001283)1.95298267
138J-shaped sella turcica (HP:0002680)1.94621067
139Thin bony cortex (HP:0002753)1.94234590
140Upper motor neuron abnormality (HP:0002127)1.93937433
141Granulocytopenia (HP:0001913)1.93601763
142Hyperacusis (HP:0010780)1.93453639
143Increased purine levels (HP:0004368)1.93187611
144Hyperuricemia (HP:0002149)1.93187611
145Increased connective tissue (HP:0009025)1.92553848
146Rhabdomyolysis (HP:0003201)1.92072619
147Gingival bleeding (HP:0000225)1.92071385
148Fatigue (HP:0012378)1.91656517
149Enlarged kidneys (HP:0000105)1.91599213
150Joint stiffness (HP:0001387)1.91424179
151Glomerulonephritis (HP:0000099)1.90555230
152Premature rupture of membranes (HP:0001788)1.90526254
153Menorrhagia (HP:0000132)1.89922082
154Gastrointestinal inflammation (HP:0004386)1.88278101
155Sensorimotor neuropathy (HP:0007141)1.88235690
156Reticulocytosis (HP:0001923)1.88156852
157Abnormal enzyme/coenzyme activity (HP:0012379)1.85567846
158Thrombocytosis (HP:0001894)1.85392313
159Increased serum ferritin (HP:0003281)1.83900005
160Hyperinsulinemic hypoglycemia (HP:0000825)1.83153795
161Exercise-induced myalgia (HP:0003738)1.83001567
162Stomatitis (HP:0010280)1.82821246
163Abnormality of the gallbladder (HP:0005264)1.81494713
164Panhypogammaglobulinemia (HP:0003139)1.81041277
165Proximal tubulopathy (HP:0000114)1.80989270
166Trismus (HP:0000211)1.80459487
167Abnormality of B cell number (HP:0010975)1.80318907
168Elevated hepatic transaminases (HP:0002910)1.80317395
169IgA deficiency (HP:0002720)1.80149164
170Microvesicular hepatic steatosis (HP:0001414)1.78589302
171Emphysema (HP:0002097)1.77534012
172Abnormal trabecular bone morphology (HP:0100671)1.77355656
173Rickets (HP:0002748)1.76746980
174Megaloblastic anemia (HP:0001889)1.75060029
175Amyloidosis (HP:0011034)1.74455912
176Increased muscle lipid content (HP:0009058)1.74240170
177Abnormality of the Achilles tendon (HP:0005109)1.73221354
178Nausea (HP:0002018)1.72296229
179Mitral stenosis (HP:0001718)1.71616164
180Hemorrhage of the eye (HP:0011885)1.69855764
181Recurrent gram-negative bacterial infections (HP:0005420)1.67344287
182Hyperglycemia (HP:0003074)1.66348634
183Autoimmune hemolytic anemia (HP:0001890)1.64470818
184Cervical subluxation (HP:0003308)1.64169662
185Retrobulbar optic neuritis (HP:0100654)1.64144105
186Optic neuritis (HP:0100653)1.64144105
187Vasculitis (HP:0002633)1.63102182
188Combined immunodeficiency (HP:0005387)1.62560828
189Generalized amyotrophy (HP:0003700)1.61934814
190Inflammation of the large intestine (HP:0002037)1.61536865

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.15984157
2ERN14.24229632
3FGFR43.20993125
4TAOK33.07617881
5SIK12.81151162
6PRPF4B2.79279700
7PKN22.70616232
8PIM22.59173853
9LATS12.53139228
10SMG12.46990474
11TRIB32.26224581
12FLT32.22033462
13ERBB42.19893973
14TESK12.00658250
15EIF2AK11.73735519
16MAP3K141.64563932
17MAP3K101.63298274
18MAPK111.63217215
19ARAF1.61458741
20STK38L1.60779781
21EEF2K1.59972032
22BUB11.59454824
23TTK1.58262385
24VRK21.57372478
25WEE11.54615509
26LATS21.45235446
27NEK21.43488432
28KDR1.42883969
29JAK31.40900847
30NEK11.40752465
31TTN1.38781960
32NME21.36908681
33CDK41.34074816
34MAP2K31.33921301
35IRAK41.33870461
36EPHA21.32128164
37TYK21.30173072
38ICK1.26693195
39ABL21.20428246
40MAPKAPK31.18609880
41ACVR1B1.18007840
42IKBKE1.17030110
43MAP3K111.16151844
44ZAP701.13261053
45IKBKB1.12910791
46CDC71.11989165
47DYRK31.10536054
48CDK121.10329683
49MAP3K131.10148009
50PTK61.09743384
51PIK3CG1.09713785
52MAP3K81.05618137
53MAP3K31.04970544
54STK101.03222414
55RIPK11.00619493
56INSRR0.98672585
57RPS6KB20.98306341
58CDK70.96078165
59TESK20.95855486
60PLK40.95480764
61MATK0.94462427
62MAP3K10.92222276
63GRK60.90198673
64IRAK20.88049523
65KIT0.85508804
66BLK0.85335993
67MTOR0.84331449
68CDK60.83542023
69GRK70.83388335
70DDR20.82534580
71RPS6KA40.82224678
72NEK90.81765923
73MAP2K40.81607782
74STK30.80843598
75MAP3K60.80083345
76MOS0.79847866
77CDC42BPA0.79286336
78EIF2AK30.78772582
79PLK10.77658155
80JAK20.76271425
81MST1R0.75743573
82BTK0.75165610
83LIMK10.73598697
84BMX0.72482826
85TGFBR20.71779887
86STK160.69103921
87SYK0.67761027
88AURKB0.67653901
89AURKA0.67301554
90LRRK20.65463917
91TAOK10.65342613
92RIPK40.64028963
93HIPK20.63212226
94DAPK10.61893830
95PDGFRA0.61381830
96DAPK30.58943464
97RPS6KL10.57394638
98RPS6KC10.57394638
99CSK0.57134275
100CDK90.57048437
101PRKAA20.56275929
102MET0.54546593
103PINK10.54332802
104MAP3K70.53960649
105TGFBR10.53585613
106MAPK40.53359547
107MAP2K20.52716373
108EPHB10.52512762
109ERBB20.52225044
110PIM10.51658003
111RPS6KA20.50468694
112IRAK30.50003356
113PRKD20.49087828
114FES0.48622116
115LCK0.48613388
116PRKAA10.48053810
117BRSK20.47691796
118CSNK1G10.47206550
119MAPKAPK20.46421307
120PTK20.46387661
121TBK10.46208350
122LYN0.45781087
123CSF1R0.44441956
124DYRK1B0.43889750
125CLK10.43432427
126SCYL20.43394931
127SIK30.43164726
128MAP3K50.42534983
129TAOK20.42425682
130BRAF0.42414070
131CHUK0.42277818
132GSK3A0.40604006
133PDK30.39645391
134PDK40.39645391
135CCNB10.39138588
136AKT20.38827959
137ATR0.38767734
138TNK20.38665600
139PAK10.38569931
140RPS6KA60.38254356
141MAP4K10.37919172
142CDK80.37799481
143IRAK10.36825194
144TIE10.36778936
145CHEK20.36710259
146AKT30.36386468
147CSNK2A20.36244294
148HCK0.35528932
149PAK40.34860406
150PASK0.34856856
151MAPK150.34394926
152STK40.33309822
153PAK20.32525559
154CSNK1G30.30062773
155CHEK10.29020403

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25490410
2Other glycan degradation_Homo sapiens_hsa005113.54045803
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.24770860
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13428109
5Nitrogen metabolism_Homo sapiens_hsa009103.09004930
6Arginine biosynthesis_Homo sapiens_hsa002202.87299172
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.79177336
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74971989
9Tryptophan metabolism_Homo sapiens_hsa003802.55007607
10Complement and coagulation cascades_Homo sapiens_hsa046102.46071351
11Fatty acid degradation_Homo sapiens_hsa000712.38770074
12Primary immunodeficiency_Homo sapiens_hsa053402.37017042
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33482008
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31271436
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.20723174
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14324362
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10006563
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04280160
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.03885052
20Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02575524
21Peroxisome_Homo sapiens_hsa041462.01527928
22Selenocompound metabolism_Homo sapiens_hsa004501.99869447
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.96423393
24Butanoate metabolism_Homo sapiens_hsa006501.89680788
25Osteoclast differentiation_Homo sapiens_hsa043801.86419022
26Leishmaniasis_Homo sapiens_hsa051401.86137995
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85889995
28Allograft rejection_Homo sapiens_hsa053301.84321727
29Lysosome_Homo sapiens_hsa041421.81690078
30Propanoate metabolism_Homo sapiens_hsa006401.81683170
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.80956808
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80205548
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.75427168
34Chemical carcinogenesis_Homo sapiens_hsa052041.75248190
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73998696
36Acute myeloid leukemia_Homo sapiens_hsa052211.73472994
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72946434
38Histidine metabolism_Homo sapiens_hsa003401.70363548
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.68700985
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68258980
41Asthma_Homo sapiens_hsa053101.68102507
42beta-Alanine metabolism_Homo sapiens_hsa004101.67666073
43One carbon pool by folate_Homo sapiens_hsa006701.66959069
44PPAR signaling pathway_Homo sapiens_hsa033201.64526544
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.64194602
46TNF signaling pathway_Homo sapiens_hsa046681.63252885
47Fatty acid metabolism_Homo sapiens_hsa012121.62510495
48Biosynthesis of amino acids_Homo sapiens_hsa012301.56345797
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55649680
50B cell receptor signaling pathway_Homo sapiens_hsa046621.55065151
51Retinol metabolism_Homo sapiens_hsa008301.51836521
52Caffeine metabolism_Homo sapiens_hsa002321.51796549
53Autoimmune thyroid disease_Homo sapiens_hsa053201.49997951
54Herpes simplex infection_Homo sapiens_hsa051681.46883664
55Sulfur relay system_Homo sapiens_hsa041221.45024223
56Influenza A_Homo sapiens_hsa051641.43124590
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.42853848
58Graft-versus-host disease_Homo sapiens_hsa053321.42568868
59Shigellosis_Homo sapiens_hsa051311.40716239
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39077295
61Malaria_Homo sapiens_hsa051441.38781646
62Staphylococcus aureus infection_Homo sapiens_hsa051501.38645867
63Pyruvate metabolism_Homo sapiens_hsa006201.38112056
64Pertussis_Homo sapiens_hsa051331.37510817
65Phenylalanine metabolism_Homo sapiens_hsa003601.36803069
66Vitamin B6 metabolism_Homo sapiens_hsa007501.35414368
67Viral myocarditis_Homo sapiens_hsa054161.35004229
68Antigen processing and presentation_Homo sapiens_hsa046121.34875440
69Rheumatoid arthritis_Homo sapiens_hsa053231.34512245
70* Folate biosynthesis_Homo sapiens_hsa007901.31318019
71Carbon metabolism_Homo sapiens_hsa012001.30028627
72Toxoplasmosis_Homo sapiens_hsa051451.29862734
73Tyrosine metabolism_Homo sapiens_hsa003501.28300853
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28106936
75Salmonella infection_Homo sapiens_hsa051321.26339696
76Tuberculosis_Homo sapiens_hsa051521.26270230
77Apoptosis_Homo sapiens_hsa042101.25423820
78Bile secretion_Homo sapiens_hsa049761.25030494
79Chronic myeloid leukemia_Homo sapiens_hsa052201.18024799
80Measles_Homo sapiens_hsa051621.15603642
81Arginine and proline metabolism_Homo sapiens_hsa003301.12569017
82Sulfur metabolism_Homo sapiens_hsa009201.12304041
83Fat digestion and absorption_Homo sapiens_hsa049751.12293163
84Hepatitis B_Homo sapiens_hsa051611.11654117
85Starch and sucrose metabolism_Homo sapiens_hsa005001.10955881
86Hepatitis C_Homo sapiens_hsa051601.09822135
87Maturity onset diabetes of the young_Homo sapiens_hsa049501.08818240
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06561482
89Legionellosis_Homo sapiens_hsa051341.06494454
90Epstein-Barr virus infection_Homo sapiens_hsa051691.05344345
91Hematopoietic cell lineage_Homo sapiens_hsa046401.05180155
92NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03332843
93ABC transporters_Homo sapiens_hsa020101.01352938
94Fatty acid elongation_Homo sapiens_hsa000620.99028085
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98263687
96HTLV-I infection_Homo sapiens_hsa051660.95930856
97Steroid biosynthesis_Homo sapiens_hsa001000.94628311
98Vitamin digestion and absorption_Homo sapiens_hsa049770.93627527
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92905766
100Lysine degradation_Homo sapiens_hsa003100.92319556
101Viral carcinogenesis_Homo sapiens_hsa052030.92015374
102Pentose phosphate pathway_Homo sapiens_hsa000300.90396909
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87654863
104Glutathione metabolism_Homo sapiens_hsa004800.86737210
105VEGF signaling pathway_Homo sapiens_hsa043700.85223342
106Notch signaling pathway_Homo sapiens_hsa043300.84935471
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84676619
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.82145273
109Pancreatic cancer_Homo sapiens_hsa052120.81662353
110African trypanosomiasis_Homo sapiens_hsa051430.81614373
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.80613766
112T cell receptor signaling pathway_Homo sapiens_hsa046600.79803825
113Type I diabetes mellitus_Homo sapiens_hsa049400.78268958
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71294929
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70895160
116Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70243195
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69356574
118Non-small cell lung cancer_Homo sapiens_hsa052230.68506757
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63968189
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62436782
121Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61598142
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60632446
123Glycerolipid metabolism_Homo sapiens_hsa005610.60213589
124Amoebiasis_Homo sapiens_hsa051460.58935974
125Phagosome_Homo sapiens_hsa041450.58415903
126Small cell lung cancer_Homo sapiens_hsa052220.56837499
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55868181
128* Metabolic pathways_Homo sapiens_hsa011000.53976578
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.53245997
130Neurotrophin signaling pathway_Homo sapiens_hsa047220.47348692
131Spliceosome_Homo sapiens_hsa030400.46440373
132Pyrimidine metabolism_Homo sapiens_hsa002400.42912122
133Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42017232
134Vibrio cholerae infection_Homo sapiens_hsa051100.41718010
135Galactose metabolism_Homo sapiens_hsa000520.41119970
136Fructose and mannose metabolism_Homo sapiens_hsa000510.40303677
137N-Glycan biosynthesis_Homo sapiens_hsa005100.37762137
138DNA replication_Homo sapiens_hsa030300.37414282
139Fatty acid biosynthesis_Homo sapiens_hsa000610.37048760
140Prolactin signaling pathway_Homo sapiens_hsa049170.36086715
141Sphingolipid signaling pathway_Homo sapiens_hsa040710.35700247
142Endocytosis_Homo sapiens_hsa041440.35645268
143Chemokine signaling pathway_Homo sapiens_hsa040620.34553458
144Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31424529
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30874214
146Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30192622
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29620797
148Linoleic acid metabolism_Homo sapiens_hsa005910.27151434
149Prion diseases_Homo sapiens_hsa050200.21693283
150Insulin resistance_Homo sapiens_hsa049310.20104167
151Mismatch repair_Homo sapiens_hsa034300.16172588
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.15768416
153Base excision repair_Homo sapiens_hsa034100.14714378
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.14403814
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14377571
156Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.13297207
157RNA transport_Homo sapiens_hsa030130.13075409
158Proteasome_Homo sapiens_hsa030500.07148392
159Systemic lupus erythematosus_Homo sapiens_hsa053220.06728738
160AMPK signaling pathway_Homo sapiens_hsa041520.05447266
161RNA polymerase_Homo sapiens_hsa030200.03161855
162Glucagon signaling pathway_Homo sapiens_hsa049220.03007496
163Nucleotide excision repair_Homo sapiens_hsa034200.02316789
164Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0679908
165p53 signaling pathway_Homo sapiens_hsa04115-0.0644384
166RNA degradation_Homo sapiens_hsa03018-0.0550126
167Purine metabolism_Homo sapiens_hsa00230-0.0535007
168Homologous recombination_Homo sapiens_hsa03440-0.0360864
169Ribosome_Homo sapiens_hsa03010-0.0231348
170Bladder cancer_Homo sapiens_hsa05219-0.0140484
171Regulation of autophagy_Homo sapiens_hsa04140-0.0019272

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