FOXS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.77964371
2positive regulation of endothelial cell apoptotic process (GO:2000353)5.70757164
3chondrocyte proliferation (GO:0035988)5.61092833
4wound healing, spreading of epidermal cells (GO:0035313)5.22672091
5collagen fibril organization (GO:0030199)5.22001952
6protein heterotrimerization (GO:0070208)5.15220484
7positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.05485512
8vascular endothelial growth factor signaling pathway (GO:0038084)5.05069662
9mesenchyme morphogenesis (GO:0072132)5.02348364
10metanephric mesenchyme development (GO:0072075)4.79346319
11kidney mesenchyme development (GO:0072074)4.74784960
12sequestering of extracellular ligand from receptor (GO:0035581)4.50768635
13skin morphogenesis (GO:0043589)4.45628522
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.44155999
15negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.38505803
16ventricular septum morphogenesis (GO:0060412)4.33048220
17relaxation of smooth muscle (GO:0044557)4.29486828
18endodermal cell differentiation (GO:0035987)4.28403085
19heart valve morphogenesis (GO:0003179)4.27629114
20lymph vessel development (GO:0001945)4.13522408
21retina vasculature morphogenesis in camera-type eye (GO:0061299)4.10359861
22wound healing, spreading of cells (GO:0044319)4.04848780
23glomerular basement membrane development (GO:0032836)4.02842299
24extracellular matrix assembly (GO:0085029)3.96494413
25endothelium development (GO:0003158)3.78363687
26potassium ion import (GO:0010107)3.72850577
27dermatan sulfate biosynthetic process (GO:0030208)3.70976221
28negative regulation of cartilage development (GO:0061037)3.69854512
29cell migration involved in heart development (GO:0060973)3.63856586
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.63043409
31positive regulation of blood vessel endothelial cell migration (GO:0043536)3.57308699
32atrioventricular valve morphogenesis (GO:0003181)3.56264635
33stress fiber assembly (GO:0043149)3.51535060
34endothelial cell morphogenesis (GO:0001886)3.50561215
35regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.49748964
36germ cell migration (GO:0008354)3.48289897
37mesenchymal cell development (GO:0014031)3.47702272
38nephron epithelium development (GO:0072009)3.47668898
39glomerular filtration (GO:0003094)3.45659366
40basement membrane organization (GO:0071711)3.45300857
41cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45104868
42nephron tubule development (GO:0072080)3.43242747
43gonadal mesoderm development (GO:0007506)3.42103072
44cGMP biosynthetic process (GO:0006182)3.40852237
45keratan sulfate catabolic process (GO:0042340)3.40729410
46extracellular fibril organization (GO:0043206)3.40516680
47cardiac ventricle morphogenesis (GO:0003208)3.40496027
48tonic smooth muscle contraction (GO:0014820)3.38914064
49pattern specification involved in kidney development (GO:0061004)3.37005849
50outflow tract morphogenesis (GO:0003151)3.36744064
51glomerulus development (GO:0032835)3.36175273
52cell migration involved in sprouting angiogenesis (GO:0002042)3.35752545
53establishment of planar polarity (GO:0001736)3.34309242
54establishment of tissue polarity (GO:0007164)3.34309242
55dermatan sulfate metabolic process (GO:0030205)3.32071106
56apoptotic cell clearance (GO:0043277)3.29761359
57cardiac right ventricle morphogenesis (GO:0003215)3.28630176
58renal filtration (GO:0097205)3.28039255
59cardiac chamber morphogenesis (GO:0003206)3.27324174
60smooth muscle tissue development (GO:0048745)3.26464024
61negative regulation of platelet activation (GO:0010544)3.25987842
62protein localization to cell surface (GO:0034394)3.25843437
63glomerular visceral epithelial cell development (GO:0072015)3.25409847
64substrate-dependent cell migration (GO:0006929)3.25200643
65response to fluid shear stress (GO:0034405)3.24999038
66negative regulation of striated muscle cell apoptotic process (GO:0010664)3.24788870
67positive regulation of odontogenesis (GO:0042482)3.22754237
68mRNA transcription from RNA polymerase II promoter (GO:0042789)3.21630626
69positive regulation of metanephros development (GO:0072216)3.20833038
70regulation of plasminogen activation (GO:0010755)3.20301870
71positive regulation of collagen biosynthetic process (GO:0032967)3.19316712
72artery smooth muscle contraction (GO:0014824)3.18795848
73heart valve formation (GO:0003188)3.16051256
74renal tubule development (GO:0061326)3.15990878
75cell proliferation involved in metanephros development (GO:0072203)3.15678144
76neural crest cell development (GO:0014032)3.15535997
77bone trabecula formation (GO:0060346)3.14610230
78negative regulation of androgen receptor signaling pathway (GO:0060766)3.13566807
79regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.13315798
80collagen metabolic process (GO:0032963)3.13276126
81negative regulation of chondrocyte differentiation (GO:0032331)3.12719649
82cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.07648196
83aorta morphogenesis (GO:0035909)3.07312244
84ventricular trabecula myocardium morphogenesis (GO:0003222)3.06668285
85Notch signaling involved in heart development (GO:0061314)3.05903372
86positive regulation of collagen metabolic process (GO:0010714)3.05093888
87mesenchymal-epithelial cell signaling (GO:0060638)3.04106308
88mesodermal cell differentiation (GO:0048333)3.03962614
89endocardial cushion morphogenesis (GO:0003203)3.03533905
90smooth muscle cell differentiation (GO:0051145)3.02026523
91negative regulation of inclusion body assembly (GO:0090084)3.01671226
92positive regulation of smooth muscle cell migration (GO:0014911)3.00443812
93collagen catabolic process (GO:0030574)3.00032014
94chondroitin sulfate catabolic process (GO:0030207)2.99318229
95lymphangiogenesis (GO:0001946)2.98825318
96negative regulation of smooth muscle cell migration (GO:0014912)2.96105071
97negative regulation of fatty acid transport (GO:2000192)2.96085444
98stem cell development (GO:0048864)2.95814959
99cell proliferation involved in kidney development (GO:0072111)2.95588267
100regulation of collagen biosynthetic process (GO:0032965)2.95108625
101negative regulation of receptor activity (GO:2000272)2.93974465
102muscle cell migration (GO:0014812)2.93885024
103positive regulation of protein kinase C signaling (GO:0090037)2.93764330
104plasma membrane repair (GO:0001778)2.93348765
105multicellular organismal macromolecule metabolic process (GO:0044259)2.93310947
106positive regulation of epithelial to mesenchymal transition (GO:0010718)2.92465458
107positive regulation of p38MAPK cascade (GO:1900745)2.91956409
108patterning of blood vessels (GO:0001569)2.91466782
109blood vessel remodeling (GO:0001974)2.91210216
110platelet-derived growth factor receptor signaling pathway (GO:0048008)2.90412769
111regulation of collagen metabolic process (GO:0010712)2.90148629
112positive regulation of catenin import into nucleus (GO:0035413)2.89779205
113regulation of endothelial cell apoptotic process (GO:2000351)2.89579090
114positive regulation of monocyte chemotaxis (GO:0090026)2.89520282
115embryonic digestive tract development (GO:0048566)2.87113252
116substrate adhesion-dependent cell spreading (GO:0034446)2.86646767
117positive regulation of axon extension (GO:0045773)2.86528500
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.86160519
119axon extension involved in axon guidance (GO:0048846)2.86160519
120embryonic camera-type eye morphogenesis (GO:0048596)2.86047934
121negative regulation of fibrinolysis (GO:0051918)2.83823843
122regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.83559233
123epithelial to mesenchymal transition (GO:0001837)2.82976244
124cardiac epithelial to mesenchymal transition (GO:0060317)2.82688470
125actin filament depolymerization (GO:0030042)2.82149223
126mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.80653099
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.80574191
128regulation of monocyte chemotaxis (GO:0090025)2.79238433
129negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.79100680
130artery morphogenesis (GO:0048844)2.79070830
131negative regulation of catenin import into nucleus (GO:0035414)2.79012677
132fibril organization (GO:0097435)2.78799950
133negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.77809231
134vasculature development (GO:0001944)2.77584262
135response to laminar fluid shear stress (GO:0034616)2.77243638
136multicellular organismal metabolic process (GO:0044236)2.76779261
137coronary vasculature morphogenesis (GO:0060977)2.76608557
138negative regulation of anoikis (GO:2000811)2.76369165
139multicellular organismal catabolic process (GO:0044243)2.76118393
140extracellular matrix organization (GO:0030198)2.75751454
141glomerular epithelial cell development (GO:0072310)2.75179966
142extracellular structure organization (GO:0043062)2.74738382
143regulation of endothelial cell chemotaxis (GO:2001026)2.74398263
144cardiac septum morphogenesis (GO:0060411)2.73466851
145epithelial cell-cell adhesion (GO:0090136)2.73433778
146cell surface receptor signaling pathway involved in heart development (GO:0061311)2.72829221
147regulation of integrin-mediated signaling pathway (GO:2001044)2.72146138
148peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.72131252
149regulation of smooth muscle cell migration (GO:0014910)2.71490656
150blood vessel endothelial cell migration (GO:0043534)2.71124055
151regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.70391655
152regulation of transforming growth factor beta2 production (GO:0032909)2.69383567
153positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.68498485
154chondroitin sulfate biosynthetic process (GO:0030206)2.68186746
155cGMP metabolic process (GO:0046068)2.65776333
156response to gravity (GO:0009629)2.65125616
157notochord development (GO:0030903)2.61471462
158blood vessel morphogenesis (GO:0048514)2.60860799
159cochlea morphogenesis (GO:0090103)2.60373265
160endothelial cell chemotaxis (GO:0035767)2.59916173
161positive regulation of cGMP metabolic process (GO:0030825)2.58038800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.95749986
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.02164449
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.41032081
4CLOCK_20551151_ChIP-Seq_293T_Human3.66127586
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.27515365
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13790871
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.07157279
8* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.84594560
9* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.78911660
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.61019447
11CJUN_26792858_Chip-Seq_BT549_Human2.47620151
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41833193
13WT1_19549856_ChIP-ChIP_CCG9911_Human2.40368367
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.34933742
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29579828
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.24549678
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.18163459
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.15368080
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13920011
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.09062194
21TP53_16413492_ChIP-PET_HCT116_Human1.89864605
22* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.89366718
23HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88959547
24BRD4_25478319_ChIP-Seq_HGPS_Human1.88177888
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88052292
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84775664
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84775664
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.83873346
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.79306498
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77711397
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.76274718
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75020991
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74700922
34SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70928808
35SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70928808
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.69253282
37* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64781584
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63537248
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.61426310
40SMC1_22415368_ChIP-Seq_MEFs_Mouse1.61093098
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60765100
42TP53_18474530_ChIP-ChIP_U2OS_Human1.60034417
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.59595968
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55937076
45SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55052687
46RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53145592
47EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53145592
48EGR1_19374776_ChIP-ChIP_THP-1_Human1.49307456
49* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.49191658
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.46823119
51ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45345849
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45067090
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.44235993
54SOX2_20726797_ChIP-Seq_SW620_Human1.42714785
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.42267367
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39175222
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38405690
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37494011
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35509004
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35400009
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31316464
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.31207367
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.31207367
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.30203240
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30099371
66MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30015541
67ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29065386
68TP53_22127205_ChIP-Seq_IMR90_Human1.26897106
69LXR_22292898_ChIP-Seq_THP-1_Human1.25557878
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25293642
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24720416
72SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24703093
73* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22532386
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21975914
75SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19172600
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19070431
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18131165
78RACK7_27058665_Chip-Seq_MCF-7_Human1.16028412
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15989381
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15776813
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15731895
82JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15475712
83HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15340321
84RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13239815
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11057897
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.09857761
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.08891539
88* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07992304
89ATF3_27146783_Chip-Seq_COLON_Human1.07640891
90TP53_23651856_ChIP-Seq_MEFs_Mouse1.06224966
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04512572
92CTCF_27219007_Chip-Seq_Bcells_Human1.04476213
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03846285
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03565173
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.03243940
96P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01984413
97RNF2_27304074_Chip-Seq_NSC_Mouse1.01387492
98EZH2_22144423_ChIP-Seq_EOC_Human1.00284857
99SA1_22415368_ChIP-Seq_MEFs_Mouse0.98946077
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98044081
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97790664
102ESR1_15608294_ChIP-ChIP_MCF-7_Human0.97622692
103EZH2_27304074_Chip-Seq_ESCs_Mouse0.96780150
104* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.94192764
105JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93969004
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91288008
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89952834
108BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89717867
109KDM2B_26808549_Chip-Seq_K562_Human0.89593480
110RING1B_27294783_Chip-Seq_NPCs_Mouse0.89339205
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.89238524
112NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88168812
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87666020
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86906275
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86533302
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86337789
117SA1_27219007_Chip-Seq_ERYTHROID_Human0.86147156
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.85967548
119* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.85579812
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.85499248
121RXR_22108803_ChIP-Seq_LS180_Human0.85317382
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.85055048
123RNF2_27304074_Chip-Seq_ESCs_Mouse0.84750232
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84602349
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.83565325
126NFIB_24661679_ChIP-Seq_LUNG_Mouse0.82882961
127KLF4_19829295_ChIP-Seq_ESCs_Human0.82131831
128CDX2_20551321_ChIP-Seq_CACO-2_Human0.81563632
129NFI_21473784_ChIP-Seq_ESCs_Mouse0.81091979
130CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80949892
131SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78022565
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77661797
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77661797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.12084096
2MP0003279_aneurysm4.74659469
3MP0005623_abnormal_meninges_morphology4.08845055
4MP0004272_abnormal_basement_membrane3.66960757
5MP0003705_abnormal_hypodermis_morpholog3.41635324
6MP0005275_abnormal_skin_tensile3.37435006
7MP0005503_abnormal_tendon_morphology3.28835050
8MP0006054_spinal_hemorrhage3.10628970
9MP0009384_cardiac_valve_regurgitation3.05132396
10MP0001958_emphysema3.00627758
11MP0010368_abnormal_lymphatic_system2.62295103
12MP0003566_abnormal_cell_adhesion2.60553429
13MP0001879_abnormal_lymphatic_vessel2.50951390
14MP0002295_abnormal_pulmonary_circulatio2.40290884
15MP0003091_abnormal_cell_migration2.25948093
16MP0000013_abnormal_adipose_tissue2.23423713
17MP0010030_abnormal_orbit_morphology2.13440048
18MP0005023_abnormal_wound_healing2.10697675
19MP0000767_abnormal_smooth_muscle1.92751973
20MP0001542_abnormal_bone_strength1.92091586
21MP0002928_abnormal_bile_duct1.80108768
22MP0005595_abnormal_vascular_smooth1.76150816
23MP0005257_abnormal_intraocular_pressure1.74636306
24MP0005508_abnormal_skeleton_morphology1.72139524
25MP0000762_abnormal_tongue_morphology1.68530177
26MP0009250_abnormal_appendicular_skeleto1.67825094
27MP0004233_abnormal_muscle_weight1.67723671
28MP0010352_gastrointestinal_tract_polyps1.59474062
29MP0005164_abnormal_response_to1.58538455
30MP0000003_abnormal_adipose_tissue1.56250754
31MP0004084_abnormal_cardiac_muscle1.54182533
32MP0002060_abnormal_skin_morphology1.52159869
33MP0008775_abnormal_heart_ventricle1.47581604
34MP0001270_distended_abdomen1.45193244
35MP0005620_abnormal_muscle_contractility1.37958880
36MP0000751_myopathy1.37881127
37MP0006138_congestive_heart_failure1.37433857
38MP0005330_cardiomyopathy1.37116443
39MP0002254_reproductive_system_inflammat1.36262019
40MP0000749_muscle_degeneration1.34557525
41MP0001348_abnormal_lacrimal_gland1.34378420
42MP0000750_abnormal_muscle_regeneration1.31629181
43MP0001243_abnormal_dermal_layer1.28242894
44MP0004883_abnormal_blood_vessel1.25902529
45* MP0002128_abnormal_blood_circulation1.25897650
46MP0000733_abnormal_muscle_development1.24461247
47MP0002972_abnormal_cardiac_muscle1.24456192
48MP0003385_abnormal_body_wall1.21690379
49MP0003045_fibrosis1.20532680
50MP0002108_abnormal_muscle_morphology1.19168132
51MP0002282_abnormal_trachea_morphology1.18682786
52MP0009053_abnormal_anal_canal1.18598153
53MP0002896_abnormal_bone_mineralization1.18057991
54MP0000462_abnormal_digestive_system1.17682909
55* MP0001614_abnormal_blood_vessel1.15519123
56MP0001299_abnormal_eye_distance/1.14541641
57MP0002127_abnormal_cardiovascular_syste1.13399306
58MP0003283_abnormal_digestive_organ1.11902861
59MP0003119_abnormal_digestive_system1.09062126
60MP0009278_abnormal_bone_marrow1.08458101
61MP0000163_abnormal_cartilage_morphology1.08128522
62MP0005084_abnormal_gallbladder_morpholo1.05928813
63MP0004134_abnormal_chest_morphology1.02418292
64MP0009379_abnormal_foot_pigmentation1.02358212
65MP0005390_skeleton_phenotype1.01878389
66MP0004087_abnormal_muscle_fiber1.00751792
67MP0003448_altered_tumor_morphology1.00650793
68MP0003950_abnormal_plasma_membrane0.99902198
69MP0005165_increased_susceptibility_to0.98887947
70MP0001544_abnormal_cardiovascular_syste0.96904324
71MP0005385_cardiovascular_system_phenoty0.96904324
72MP0003942_abnormal_urinary_system0.96281242
73MP0000249_abnormal_blood_vessel0.94431418
74MP0003935_abnormal_craniofacial_develop0.94131829
75MP0002925_abnormal_cardiovascular_devel0.94124547
76MP0002009_preneoplasia0.93652415
77MP0003828_pulmonary_edema0.91700986
78MP0010630_abnormal_cardiac_muscle0.90766547
79MP0000343_altered_response_to0.90632111
80MP0005375_adipose_tissue_phenotype0.90084577
81MP0002168_other_aberrant_phenotype0.89594844
82MP0002877_abnormal_melanocyte_morpholog0.89400996
83MP0002115_abnormal_skeleton_extremities0.89387354
84MP0000537_abnormal_urethra_morphology0.88844664
85MP0000534_abnormal_ureter_morphology0.87989747
86MP0001756_abnormal_urination0.87543916
87MP0005367_renal/urinary_system_phenotyp0.87353445
88MP0000516_abnormal_urinary_system0.87353445
89MP0005409_darkened_coat_color0.86536615
90MP0000230_abnormal_systemic_arterial0.85502091
91MP0004484_altered_response_of0.84423842
92MP0003724_increased_susceptibility_to0.83291810
93MP0002933_joint_inflammation0.82885483
94MP0002998_abnormal_bone_remodeling0.82840363
95MP0005197_abnormal_uvea_morphology0.82291952
96MP0003075_altered_response_to0.82088009
97MP0002166_altered_tumor_susceptibility0.81806143
98MP0001346_abnormal_lacrimal_gland0.78714563
99MP0004085_abnormal_heartbeat0.77325131
100MP0000049_abnormal_middle_ear0.76886151
101MP0005369_muscle_phenotype0.76525539
102MP0002697_abnormal_eye_size0.76510109
103MP0000538_abnormal_urinary_bladder0.76324528
104MP0003755_abnormal_palate_morphology0.75651889
105MP0002113_abnormal_skeleton_development0.74993077
106MP0002932_abnormal_joint_morphology0.74698308
107MP0003941_abnormal_skin_development0.74114003
108MP0005388_respiratory_system_phenotype0.74103291
109MP0002133_abnormal_respiratory_system0.74103291
110MP0001533_abnormal_skeleton_physiology0.73379332
111MP0004215_abnormal_myocardial_fiber0.71946521
112MP0002089_abnormal_postnatal_growth/wei0.71727606
113MP0002249_abnormal_larynx_morphology0.70671101
114MP0001915_intracranial_hemorrhage0.70606708
115MP0002837_dystrophic_cardiac_calcinosis0.70217072
116MP0004036_abnormal_muscle_relaxation0.70197495
117MP0003115_abnormal_respiratory_system0.70021972
118MP0000858_altered_metastatic_potential0.69904545
119MP0009840_abnormal_foam_cell0.69351899
120MP0000759_abnormal_skeletal_muscle0.69122827
121MP0002006_tumorigenesis0.69068042
122MP0003303_peritoneal_inflammation0.68881171
123MP0003795_abnormal_bone_structure0.67328735
124MP0005410_abnormal_fertilization0.67144865
125MP0002106_abnormal_muscle_physiology0.64400506
126MP0003136_yellow_coat_color0.60781321
127MP0002116_abnormal_craniofacial_bone0.60720691
128MP0001664_abnormal_digestion0.59117818
129MP0002734_abnormal_mechanical_nocicepti0.58511516
130MP0000266_abnormal_heart_morphology0.58151200

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.66719396
2Protrusio acetabuli (HP:0003179)7.44640446
3Aortic aneurysm (HP:0004942)5.66289350
4Aortic dissection (HP:0002647)5.58077935
5Cerebral aneurysm (HP:0004944)4.56525990
6Peritonitis (HP:0002586)4.30766420
7Abnormality of dentin (HP:0010299)3.99596139
8Soft skin (HP:0000977)3.96915086
9Dilatation of the ascending aorta (HP:0005111)3.90289205
10Broad metatarsal (HP:0001783)3.85196537
11Shallow orbits (HP:0000586)3.80533518
12Spinal rigidity (HP:0003306)3.76302804
13Wormian bones (HP:0002645)3.74852537
14Ankle contracture (HP:0006466)3.73242100
15Atrophic scars (HP:0001075)3.71296574
16Bladder diverticulum (HP:0000015)3.71086690
17Axonal loss (HP:0003447)3.68009230
18Increased density of long bones (HP:0006392)3.67430929
19Vascular tortuosity (HP:0004948)3.60092646
20Neonatal short-limb short stature (HP:0008921)3.51169717
21Biconcave vertebral bodies (HP:0004586)3.49730738
22Increased connective tissue (HP:0009025)3.41344206
23Type 1 muscle fiber predominance (HP:0003803)3.37101804
24Fragile skin (HP:0001030)3.35728193
25Short hallux (HP:0010109)3.34958874
26Vertebral compression fractures (HP:0002953)3.29557863
27Mitral stenosis (HP:0001718)3.23493884
28Joint stiffness (HP:0001387)3.19528407
29Aplasia/Hypoplasia of the hallux (HP:0008362)3.12753443
30Blue sclerae (HP:0000592)3.11721403
31Anterior segment dysgenesis (HP:0007700)3.01239848
32Spondylolisthesis (HP:0003302)2.95995143
33Ulnar deviation of the wrist (HP:0003049)2.88711223
34Aortic valve stenosis (HP:0001650)2.86837562
35Aneurysm (HP:0002617)2.85868492
36Increased variability in muscle fiber diameter (HP:0003557)2.84232988
37Focal segmental glomerulosclerosis (HP:0000097)2.83544874
38Infantile muscular hypotonia (HP:0008947)2.79240487
39Scotoma (HP:0000575)2.77800075
40Chondrocalcinosis (HP:0000934)2.74143569
41Mitral valve prolapse (HP:0001634)2.70690420
42Bowel diverticulosis (HP:0005222)2.65154258
43Pulmonary artery stenosis (HP:0004415)2.63486071
44Abnormal delivery (HP:0001787)2.63394670
45Abnormality of Sharpey fibers (HP:0100685)2.62382517
46Congenital, generalized hypertrichosis (HP:0004540)2.59282111
47Depressed nasal tip (HP:0000437)2.55624481
48Genu recurvatum (HP:0002816)2.54240534
49Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.53363073
50Broad ribs (HP:0000885)2.53333957
51Mitral regurgitation (HP:0001653)2.49954669
52Abnormality of skeletal muscle fiber size (HP:0012084)2.49679331
53Hyperextensible skin (HP:0000974)2.47973412
54Camptodactyly of toe (HP:0001836)2.46814582
55Abnormality of the ischium (HP:0003174)2.45900771
56Venous abnormality (HP:0002624)2.41793195
57Scapular winging (HP:0003691)2.40853587
58Short nail (HP:0001799)2.40246357
59Round ear (HP:0100830)2.39265753
60Venous insufficiency (HP:0005293)2.37613458
61Follicular hyperkeratosis (HP:0007502)2.36934888
62Elbow flexion contracture (HP:0002987)2.36091007
63Arterial tortuosity (HP:0005116)2.35252752
64Abnormality of the peritoneum (HP:0002585)2.31233374
65Tibial bowing (HP:0002982)2.28683822
66Prominent supraorbital ridges (HP:0000336)2.27350300
67Mesangial abnormality (HP:0001966)2.26324832
68Hydroureter (HP:0000072)2.25637572
69Cervical subluxation (HP:0003308)2.22514828
70Upper limb muscle weakness (HP:0003484)2.22342466
71Mildly elevated creatine phosphokinase (HP:0008180)2.22084856
72Ectopia lentis (HP:0001083)2.21844266
73Mesomelia (HP:0003027)2.20960696
74Absent toe (HP:0010760)2.19685499
75Muscle fiber splitting (HP:0003555)2.18452266
76Overgrowth (HP:0001548)2.16790152
77Ulnar claw (HP:0001178)2.16635754
78Bone cyst (HP:0012062)2.16221492
79Limited hip movement (HP:0008800)2.14157267
80Persistence of primary teeth (HP:0006335)2.13637250
81Abnormality of the vertebral endplates (HP:0005106)2.12837510
82Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.12592532
83Delayed gross motor development (HP:0002194)2.12364180
84Vertebral arch anomaly (HP:0008438)2.08861222
85Wrist flexion contracture (HP:0001239)2.07900008
86Type 2 muscle fiber atrophy (HP:0003554)2.07045924
87Posterior subcapsular cataract (HP:0007787)2.04582088
88Stroke (HP:0001297)2.03163111
89Nonimmune hydrops fetalis (HP:0001790)2.02609143
90Hemiplegia (HP:0002301)2.02283486
91Congenital glaucoma (HP:0001087)2.02218567
92Joint laxity (HP:0001388)2.02176995
93Asymmetric septal hypertrophy (HP:0001670)2.02020200
94Aplasia involving bones of the extremities (HP:0009825)2.01887599
95Aplasia involving bones of the upper limbs (HP:0009823)2.01887599
96Aplasia of the phalanges of the hand (HP:0009802)2.01887599
97Patent foramen ovale (HP:0001655)2.01115007
98Hemiparesis (HP:0001269)2.00150725
99Distal upper limb amyotrophy (HP:0007149)1.99907910
100Upper limb amyotrophy (HP:0009129)1.99907910
101Radial bowing (HP:0002986)1.99757473
102Gingival overgrowth (HP:0000212)1.98647106
103Torticollis (HP:0000473)1.98376839
104Glomerulosclerosis (HP:0000096)1.98190965
105Femoral bowing (HP:0002980)1.96814053
106Gastrointestinal dysmotility (HP:0002579)1.94721194
107Right ventricular cardiomyopathy (HP:0011663)1.94012470
108Difficulty climbing stairs (HP:0003551)1.93421917
109Flexion contracture of toe (HP:0005830)1.93327401
110Joint contractures involving the joints of the feet (HP:0100492)1.93327401
111Hypercalcemia (HP:0003072)1.91536802
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.91424445
113Osteolytic defects of the hand bones (HP:0009699)1.91424445
114Increased corneal curvature (HP:0100692)1.90516560
115Keratoconus (HP:0000563)1.90516560
116Fibular aplasia (HP:0002990)1.87181565
117Abnormality of the acetabulum (HP:0003170)1.86332996
118Buphthalmos (HP:0000557)1.85720441
119Subcapsular cataract (HP:0000523)1.85140054
120Muscle fiber atrophy (HP:0100295)1.84968757
121Hypoplastic heart (HP:0001961)1.84299093
122Hypoplastic left heart (HP:0004383)1.84232930
123Distal lower limb amyotrophy (HP:0008944)1.84047935
124Epiphyseal dysplasia (HP:0002656)1.83753488
125Knee flexion contracture (HP:0006380)1.82987770
126Small epiphyses (HP:0010585)1.82668913
127Tarsal synostosis (HP:0008368)1.82083086
128Severe Myopia (HP:0011003)1.81985113
129Wide anterior fontanel (HP:0000260)1.81174296
130Retinal detachment (HP:0000541)1.81154111
131Hypoplasia of the iris (HP:0007676)1.80978113
132Aortic regurgitation (HP:0001659)1.80814710
133Bowed forearm bones (HP:0003956)1.80607512
134Bowing of the arm (HP:0006488)1.80607512
135Abnormality of the anterior chamber (HP:0000593)1.80420339
136Abnormality of the neuromuscular junction (HP:0003398)1.79573774
137Fatigable weakness (HP:0003473)1.79573774
138Distal lower limb muscle weakness (HP:0009053)1.79427824
139Facial diplegia (HP:0001349)1.79402990
140Slender build (HP:0001533)1.79319733
141Hypoplastic ischia (HP:0003175)1.78569552
142Thin bony cortex (HP:0002753)1.78287996
143Ventricular tachycardia (HP:0004756)1.76187796
144Adactyly (HP:0009776)1.75882410
145Abnormality of the calcaneus (HP:0008364)1.74865224
146Bicuspid aortic valve (HP:0001647)1.71045734
147Platyspondyly (HP:0000926)1.69785212
148Lipoatrophy (HP:0100578)1.69393331

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.68128215
2TTN3.95669103
3PDGFRA3.82556388
4TSSK63.56378516
5DDR23.18855095
6PAK22.96665212
7TRIB32.61156810
8PIK3CG2.46844681
9PTK2B2.44331064
10VRK22.43738238
11PAK32.42964602
12DMPK2.31565210
13LATS22.31453246
14EPHB22.30851451
15TESK12.13043838
16KIT2.11025985
17LATS12.09277080
18ERN12.07175731
19PNCK2.03342871
20MAPK72.01727452
21EPHA31.93371788
22LIMK11.92231511
23VRK11.91635053
24TRPM71.89320667
25BMX1.87928014
26FRK1.82008974
27CDC42BPA1.69590440
28PTK21.68962311
29MAP3K101.62004525
30CDK31.47040449
31ROCK11.46630417
32RPS6KA41.46108903
33LMTK21.42559335
34PDGFRB1.41612050
35NUAK11.38588444
36DAPK31.38215663
37AKT31.35038875
38PIM21.34807517
39MAP3K121.26636086
40KDR1.24757132
41FER1.24230664
42PRKG21.22847411
43MET1.19622329
44TAOK11.16297982
45ZAK1.15840674
46ERBB31.13497809
47LRRK21.12808778
48ABL21.12686770
49TGFBR21.10903525
50NME21.09016501
51PIK3CA1.07385893
52ILK1.05544239
53PRKD31.04702622
54TIE11.04659928
55MAP2K11.01740380
56NME11.01273559
57MAPKAPK30.93796104
58PKN20.91759236
59ERBB40.87132666
60INSR0.86581134
61PTK60.85302811
62NTRK10.84064945
63MAP3K110.81105671
64STK390.78822965
65MAPK120.77716763
66RPS6KB20.76502271
67IRAK20.72912136
68TGFBR10.72118149
69PRKD10.70955537
70RIPK10.69801198
71PHKG10.67887309
72PHKG20.67887309
73PAK10.66533474
74MOS0.66384189
75STK380.64343049
76OBSCN0.64019541
77RET0.63385662
78MAPK150.61480535
79EPHB10.61149248
80NEK90.60432195
81PDK20.59806204
82FGFR10.59031164
83FGFR30.58131217
84EPHA20.57855457
85MAPKAPK50.57657258
86EIF2AK10.57442950
87MAP3K30.57134093
88MAP2K20.54777664
89RPS6KA20.54292927
90ROCK20.53897236
91CAMK10.53385188
92PRKD20.53350273
93STK38L0.53117911
94WEE10.52123421
95SIK10.51531132
96MAP3K140.48930858
97TYRO30.48830640
98FES0.48685713
99ADRBK10.47859218
100INSRR0.46676197
101CAMK2D0.45590427
102TBK10.45482052
103MAPKAPK20.44459886
104CAMK2B0.44380323
105IRAK40.43085442
106MTOR0.41509852
107MAP2K30.40733873
108MAP2K70.39708228
109STK30.39205628
110SRC0.39013834
111CSK0.37847594
112FGFR40.37312263
113IGF1R0.36317656
114MAPK40.35863966
115PRKAA20.35606666
116PAK60.35346695
117FGFR20.35020445
118PAK40.33202157
119MARK10.32627323
120EGFR0.31870447
121GSK3A0.31094277
122EEF2K0.30578418
123ICK0.30416756
124TAF10.30395052
125PRKCG0.29381574
126PRKCE0.28938957
127MUSK0.28893046
128CAMK2A0.28472036
129CDK140.28071207
130PRKCD0.26699346
131CDK11A0.26147236
132CDK150.25974486
133MAP3K10.25497866
134PRKG10.24967095
135TEC0.24636084
136MST40.24557595
137ITK0.23003017
138RAF10.22691607
139CAMK2G0.22671529
140NLK0.22347071
141STK110.21999718

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.46192481
2Focal adhesion_Homo sapiens_hsa045103.67324807
3Dilated cardiomyopathy_Homo sapiens_hsa054143.09252006
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.03639076
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.89507265
6Ribosome_Homo sapiens_hsa030102.63721137
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.46005649
8AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.40017032
9Proteoglycans in cancer_Homo sapiens_hsa052052.31008876
10Amoebiasis_Homo sapiens_hsa051462.27273169
11Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.17784723
12Bladder cancer_Homo sapiens_hsa052192.06459160
13Malaria_Homo sapiens_hsa051442.00914362
14Adherens junction_Homo sapiens_hsa045201.90887850
15Protein digestion and absorption_Homo sapiens_hsa049741.89430112
16Regulation of actin cytoskeleton_Homo sapiens_hsa048101.87675557
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.83731337
18TGF-beta signaling pathway_Homo sapiens_hsa043501.81999311
19Small cell lung cancer_Homo sapiens_hsa052221.80539559
20Vascular smooth muscle contraction_Homo sapiens_hsa042701.70329722
21MicroRNAs in cancer_Homo sapiens_hsa052061.64980543
22Sulfur relay system_Homo sapiens_hsa041221.64701869
23Leukocyte transendothelial migration_Homo sapiens_hsa046701.61816448
24Melanoma_Homo sapiens_hsa052181.59077279
25Hippo signaling pathway_Homo sapiens_hsa043901.50192301
26Folate biosynthesis_Homo sapiens_hsa007901.49908271
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.41753990
28Rap1 signaling pathway_Homo sapiens_hsa040151.36918360
29Salivary secretion_Homo sapiens_hsa049701.34222100
30Parkinsons disease_Homo sapiens_hsa050121.33650089
31Platelet activation_Homo sapiens_hsa046111.31481817
32Shigellosis_Homo sapiens_hsa051311.29908752
33Prostate cancer_Homo sapiens_hsa052151.28452588
34Oxidative phosphorylation_Homo sapiens_hsa001901.24394220
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.22997029
36Gap junction_Homo sapiens_hsa045401.20978459
37TNF signaling pathway_Homo sapiens_hsa046681.13581179
38Pathways in cancer_Homo sapiens_hsa052001.11329842
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09505525
40Viral myocarditis_Homo sapiens_hsa054161.07752099
41HIF-1 signaling pathway_Homo sapiens_hsa040661.07672433
42Glioma_Homo sapiens_hsa052141.07378599
43Renal cell carcinoma_Homo sapiens_hsa052111.04797871
44Hedgehog signaling pathway_Homo sapiens_hsa043401.04717417
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04342475
46Tight junction_Homo sapiens_hsa045301.03587793
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00237420
48Chronic myeloid leukemia_Homo sapiens_hsa052201.00148857
49Huntingtons disease_Homo sapiens_hsa050160.99697823
50Basal cell carcinoma_Homo sapiens_hsa052170.98401270
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98368820
52Toxoplasmosis_Homo sapiens_hsa051450.98292247
53p53 signaling pathway_Homo sapiens_hsa041150.94813864
54Bile secretion_Homo sapiens_hsa049760.93839336
55Pancreatic cancer_Homo sapiens_hsa052120.93639733
56Axon guidance_Homo sapiens_hsa043600.93401025
57Ras signaling pathway_Homo sapiens_hsa040140.92677150
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90932568
59Dorso-ventral axis formation_Homo sapiens_hsa043200.89765215
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89754892
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89002877
62Salmonella infection_Homo sapiens_hsa051320.88599716
63Alzheimers disease_Homo sapiens_hsa050100.88485059
64Circadian entrainment_Homo sapiens_hsa047130.88408281
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84724052
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84192200
67Osteoclast differentiation_Homo sapiens_hsa043800.80515039
68Leishmaniasis_Homo sapiens_hsa051400.79863892
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78328324
70MAPK signaling pathway_Homo sapiens_hsa040100.77876916
71HTLV-I infection_Homo sapiens_hsa051660.77010714
72Estrogen signaling pathway_Homo sapiens_hsa049150.75011637
73Complement and coagulation cascades_Homo sapiens_hsa046100.74079522
74Apoptosis_Homo sapiens_hsa042100.73667286
75Phagosome_Homo sapiens_hsa041450.73600814
76Oxytocin signaling pathway_Homo sapiens_hsa049210.71745512
77Hematopoietic cell lineage_Homo sapiens_hsa046400.71235370
78Insulin secretion_Homo sapiens_hsa049110.70901972
79VEGF signaling pathway_Homo sapiens_hsa043700.70625896
80Notch signaling pathway_Homo sapiens_hsa043300.68864364
81Ovarian steroidogenesis_Homo sapiens_hsa049130.68443255
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68005887
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66449267
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.66021138
85GABAergic synapse_Homo sapiens_hsa047270.65805098
86Rheumatoid arthritis_Homo sapiens_hsa053230.65741999
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.65571909
88Morphine addiction_Homo sapiens_hsa050320.65557389
89Renin secretion_Homo sapiens_hsa049240.64928223
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64794434
91Calcium signaling pathway_Homo sapiens_hsa040200.64319220
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63234400
93Pancreatic secretion_Homo sapiens_hsa049720.62704247
94Gastric acid secretion_Homo sapiens_hsa049710.62479667
95ErbB signaling pathway_Homo sapiens_hsa040120.61543755
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.60626795
97Hepatitis B_Homo sapiens_hsa051610.58970358
98cAMP signaling pathway_Homo sapiens_hsa040240.58712412
99Long-term depression_Homo sapiens_hsa047300.57882769
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56348778
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.54933529
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53684546
103Wnt signaling pathway_Homo sapiens_hsa043100.53460872
104Endocytosis_Homo sapiens_hsa041440.53395388
105Melanogenesis_Homo sapiens_hsa049160.52504406
106Glutathione metabolism_Homo sapiens_hsa004800.52006517
107Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49067074
108Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48188019
109Galactose metabolism_Homo sapiens_hsa000520.48076111
110Olfactory transduction_Homo sapiens_hsa047400.47413574
111GnRH signaling pathway_Homo sapiens_hsa049120.46798614
112Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45389044
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44938361
114Amphetamine addiction_Homo sapiens_hsa050310.44716595
115Arginine and proline metabolism_Homo sapiens_hsa003300.43280841
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.42916456
117Cocaine addiction_Homo sapiens_hsa050300.42500731
118Pertussis_Homo sapiens_hsa051330.42295149
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.41066871
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.40017666
121Cardiac muscle contraction_Homo sapiens_hsa042600.39976993
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39838115
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.39522925
124Thyroid hormone synthesis_Homo sapiens_hsa049180.39363931
125Prion diseases_Homo sapiens_hsa050200.38483325
126Vibrio cholerae infection_Homo sapiens_hsa051100.36212329
127Insulin resistance_Homo sapiens_hsa049310.34265985
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33868438
129Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33438210
130Colorectal cancer_Homo sapiens_hsa052100.32140020
131Collecting duct acid secretion_Homo sapiens_hsa049660.31126936
132Other glycan degradation_Homo sapiens_hsa005110.30705566
133PPAR signaling pathway_Homo sapiens_hsa033200.30065982
134FoxO signaling pathway_Homo sapiens_hsa040680.27437890

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