FOXRED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.50595522
2lysine metabolic process (GO:0006553)5.41604962
3lysine catabolic process (GO:0006554)5.41604962
4fatty acid beta-oxidation (GO:0006635)5.07705792
5succinate metabolic process (GO:0006105)5.07205472
62-oxoglutarate metabolic process (GO:0006103)4.97694100
7NADH metabolic process (GO:0006734)4.91482453
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.83871719
9L-phenylalanine catabolic process (GO:0006559)4.83871719
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.78970451
11L-phenylalanine metabolic process (GO:0006558)4.78970451
12acetyl-CoA metabolic process (GO:0006084)4.75386801
13regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.69808603
14glyoxylate metabolic process (GO:0046487)4.63218145
15branched-chain amino acid catabolic process (GO:0009083)4.61493807
16fatty acid catabolic process (GO:0009062)4.54981664
17valine metabolic process (GO:0006573)4.52879813
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46009637
19fatty acid oxidation (GO:0019395)4.43276498
20carnitine shuttle (GO:0006853)4.41786467
21tricarboxylic acid metabolic process (GO:0072350)4.41668506
22aspartate family amino acid catabolic process (GO:0009068)4.37125882
23fatty acid transmembrane transport (GO:1902001)4.36923089
24lipid oxidation (GO:0034440)4.35729928
25oxaloacetate metabolic process (GO:0006107)4.29649654
26regulation of acyl-CoA biosynthetic process (GO:0050812)4.25308068
27short-chain fatty acid metabolic process (GO:0046459)4.22514657
28branched-chain amino acid metabolic process (GO:0009081)4.20724479
29aromatic amino acid family catabolic process (GO:0009074)4.17697648
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13073029
31alpha-linolenic acid metabolic process (GO:0036109)4.09709381
32monocarboxylic acid catabolic process (GO:0072329)4.07185019
33regulation of sequestering of triglyceride (GO:0010889)4.06799116
34oxidative phosphorylation (GO:0006119)3.99928901
35regulation of coenzyme metabolic process (GO:0051196)3.96203952
36regulation of cofactor metabolic process (GO:0051193)3.96203952
37L-serine metabolic process (GO:0006563)3.93765086
38energy coupled proton transport, down electrochemical gradient (GO:0015985)3.90555639
39ATP synthesis coupled proton transport (GO:0015986)3.90555639
40DNA strand elongation involved in DNA replication (GO:0006271)3.84233590
41biotin metabolic process (GO:0006768)3.83629752
42regulation of fatty acid oxidation (GO:0046320)3.83226108
43regulation of triglyceride catabolic process (GO:0010896)3.79126564
44telomere maintenance via semi-conservative replication (GO:0032201)3.75115968
45amino-acid betaine metabolic process (GO:0006577)3.74800043
46respiratory electron transport chain (GO:0022904)3.72044350
47indole-containing compound catabolic process (GO:0042436)3.68105311
48indolalkylamine catabolic process (GO:0046218)3.68105311
49tryptophan catabolic process (GO:0006569)3.68105311
50triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.65131839
51kynurenine metabolic process (GO:0070189)3.62836443
52cellular ketone body metabolic process (GO:0046950)3.62385750
53electron transport chain (GO:0022900)3.59929956
54DNA strand elongation (GO:0022616)3.59078418
55carnitine metabolic process (GO:0009437)3.58916725
56proteasome assembly (GO:0043248)3.56964051
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.55935128
58acyl-CoA biosynthetic process (GO:0071616)3.55868356
59thioester biosynthetic process (GO:0035384)3.55868356
60tryptophan metabolic process (GO:0006568)3.49099198
61mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48027305
62coenzyme catabolic process (GO:0009109)3.47107649
63regulation of mitochondrial translation (GO:0070129)3.45575235
64alpha-amino acid catabolic process (GO:1901606)3.44699774
65mitochondrial respiratory chain complex assembly (GO:0033108)3.42631933
66carnitine transmembrane transport (GO:1902603)3.41629510
67organic acid catabolic process (GO:0016054)3.41533816
68carboxylic acid catabolic process (GO:0046395)3.41533816
69bile acid biosynthetic process (GO:0006699)3.40500476
70thioester metabolic process (GO:0035383)3.38539167
71acyl-CoA metabolic process (GO:0006637)3.38539167
72protein complex biogenesis (GO:0070271)3.38517158
73mitochondrial respiratory chain complex I assembly (GO:0032981)3.35256845
74NADH dehydrogenase complex assembly (GO:0010257)3.35256845
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35256845
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.34136515
77coenzyme A metabolic process (GO:0015936)3.31338226
78positive regulation of fatty acid oxidation (GO:0046321)3.30990118
79fatty acid homeostasis (GO:0055089)3.29558971
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.28914700
81somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28914700
82regulation of sulfur metabolic process (GO:0042762)3.28756410
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.28385444
84DNA replication checkpoint (GO:0000076)3.27380331
85amino-acid betaine transport (GO:0015838)3.25129976
86carnitine transport (GO:0015879)3.25129976
87cellular amino acid catabolic process (GO:0009063)3.24277506
88chaperone-mediated protein transport (GO:0072321)3.23944728
89establishment of integrated proviral latency (GO:0075713)3.22205659
90ketone body metabolic process (GO:1902224)3.20343032
91respiratory chain complex IV assembly (GO:0008535)3.15655317
92tRNA aminoacylation for protein translation (GO:0006418)3.13385990
93tRNA aminoacylation (GO:0043039)3.12772226
94amino acid activation (GO:0043038)3.12772226
95telomere maintenance via recombination (GO:0000722)3.12528754
96ethanol oxidation (GO:0006069)3.11952740
97ubiquinone biosynthetic process (GO:0006744)3.10310155
98quinone biosynthetic process (GO:1901663)3.10310155
99rRNA modification (GO:0000154)3.07824796
100negative regulation of fatty acid biosynthetic process (GO:0045717)3.06983491
101NAD metabolic process (GO:0019674)3.06788644
102glycine metabolic process (GO:0006544)3.06720945
103pseudouridine synthesis (GO:0001522)3.06607624
104regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.06130671
105aromatic amino acid family metabolic process (GO:0009072)3.04528840
106plasma lipoprotein particle clearance (GO:0034381)3.03007365
107negative regulation of fatty acid metabolic process (GO:0045922)3.02562468
108sarcomere organization (GO:0045214)3.00715642
109chromatin remodeling at centromere (GO:0031055)3.00362150
110nucleotide-excision repair, DNA gap filling (GO:0006297)3.00308453
111positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00223038
112protein targeting to mitochondrion (GO:0006626)2.99906386
113positive regulation of fatty acid beta-oxidation (GO:0032000)2.99362200
114spliceosomal snRNP assembly (GO:0000387)2.98566468
115nucleobase biosynthetic process (GO:0046112)2.97502330
116dicarboxylic acid metabolic process (GO:0043648)2.96539729
117serine family amino acid catabolic process (GO:0009071)2.96251619
118regulation of fatty acid beta-oxidation (GO:0031998)2.96244132
119cytochrome complex assembly (GO:0017004)2.95816592
120acylglycerol homeostasis (GO:0055090)2.95449160
121triglyceride homeostasis (GO:0070328)2.95449160
122dicarboxylic acid biosynthetic process (GO:0043650)2.94816833
123mitotic recombination (GO:0006312)2.94421384
124regulation of cholesterol metabolic process (GO:0090181)2.94203047
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.93791170
126phospholipid homeostasis (GO:0055091)2.93651037
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93379401
128negative regulation of ligase activity (GO:0051352)2.93379401
129regulation of cellular amino acid metabolic process (GO:0006521)2.92688907
130DNA damage response, detection of DNA damage (GO:0042769)2.92230797
131cardiac myofibril assembly (GO:0055003)2.92181864
132replication fork processing (GO:0031297)2.90584860
133establishment of protein localization to mitochondrion (GO:0072655)2.90506788
134GMP metabolic process (GO:0046037)2.89624940
135L-methionine salvage (GO:0071267)2.88734091
136L-methionine biosynthetic process (GO:0071265)2.88734091
137amino acid salvage (GO:0043102)2.88734091
138DNA replication initiation (GO:0006270)2.88497412
139sulfur amino acid catabolic process (GO:0000098)2.86879700
140urea cycle (GO:0000050)2.86426795
141urea metabolic process (GO:0019627)2.86426795
142aerobic respiration (GO:0009060)2.86074108
143purine nucleobase biosynthetic process (GO:0009113)2.85972518
144establishment of viral latency (GO:0019043)2.85716710
145DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85651107
146tyrosine metabolic process (GO:0006570)2.85591838
147ubiquinone metabolic process (GO:0006743)2.85562298
148serine family amino acid biosynthetic process (GO:0009070)2.85472921
149cofactor catabolic process (GO:0051187)2.85360441
150signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84623465
151signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84623465
152signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84623465
153signal transduction involved in cell cycle checkpoint (GO:0072395)2.82278233
154CENP-A containing nucleosome assembly (GO:0034080)2.82039616
155regulation of mitotic spindle checkpoint (GO:1903504)2.81781815
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.81781815
157complement activation, alternative pathway (GO:0006957)2.81213661
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81043753
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81043753
160meiotic chromosome segregation (GO:0045132)2.80716736
161signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79890894
162signal transduction involved in DNA damage checkpoint (GO:0072422)2.79890894
163protein localization to mitochondrion (GO:0070585)2.79331768
164mitochondrial RNA metabolic process (GO:0000959)2.75843073
165regulation of translational fidelity (GO:0006450)2.75186302
166positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.74922293
167cullin deneddylation (GO:0010388)2.74893622
168base-excision repair, AP site formation (GO:0006285)2.73359405
169pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.73094763
170IMP biosynthetic process (GO:0006188)2.72794147
171ribosomal small subunit assembly (GO:0000028)2.72500115
172base-excision repair (GO:0006284)2.72016513
173telomere maintenance via telomere lengthening (GO:0010833)2.70001852
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.69978950
175termination of RNA polymerase III transcription (GO:0006386)2.69978950
176tRNA metabolic process (GO:0006399)2.68889874
177transcription-coupled nucleotide-excision repair (GO:0006283)2.67281561
178maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66381496
179positive regulation of ligase activity (GO:0051351)2.65976111
180mitotic metaphase plate congression (GO:0007080)2.63318843
181DNA unwinding involved in DNA replication (GO:0006268)2.62679213
182nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62269389
183resolution of meiotic recombination intermediates (GO:0000712)2.61256727
184water-soluble vitamin biosynthetic process (GO:0042364)2.61140690
185guanosine-containing compound biosynthetic process (GO:1901070)2.61096220
186aspartate family amino acid biosynthetic process (GO:0009067)2.59663323
187mitotic sister chromatid segregation (GO:0000070)2.59370629

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75872157
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.71188263
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.46713141
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.16252187
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73521361
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.48335170
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.44315829
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.27510239
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02433518
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.95928168
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95380100
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.84174532
13GATA1_22025678_ChIP-Seq_K562_Human2.62425719
14* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55173094
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47167906
16* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.46147368
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41397965
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.35825379
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35418588
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.28726174
21* SRF_21415370_ChIP-Seq_HL-1_Mouse2.27549720
22* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25676571
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.11741563
24* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10773509
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.05956640
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.03141792
27TTF2_22483619_ChIP-Seq_HELA_Human1.98832206
28E2F7_22180533_ChIP-Seq_HELA_Human1.98428712
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95755936
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88442057
31* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83652483
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78784965
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.75762335
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69415110
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.68050730
36* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67350655
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.62825770
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.61168332
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.60692487
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60646249
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59609577
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59225879
43* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57906891
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.57247678
45MYC_18940864_ChIP-ChIP_HL60_Human1.56212583
46ELK1_19687146_ChIP-ChIP_HELA_Human1.54673499
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.52790067
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52492040
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52236497
50TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49670329
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47040648
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42773883
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40198480
54ZNF274_21170338_ChIP-Seq_K562_Hela1.40067353
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39587438
56TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.34390532
57PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33365874
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32151228
59FOXP3_21729870_ChIP-Seq_TREG_Human1.32115452
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31757756
61* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31536957
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30786914
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27199294
64* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26321039
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26135044
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25864370
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25852060
68GATA4_21415370_ChIP-Seq_HL-1_Mouse1.25796051
69CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.24453270
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24034213
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23306738
72CLOCK_20551151_ChIP-Seq_293T_Human1.21986642
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21186199
74* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.20852034
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20404830
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.19533238
77NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18746579
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18393820
79* DCP1A_22483619_ChIP-Seq_HELA_Human1.18075091
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.16430164
81VDR_23849224_ChIP-Seq_CD4+_Human1.16425260
82* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15817785
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.14506742
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.14168323
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14087974
86LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12398799
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.10360074
88* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09963247
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08662463
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06844266
91CIITA_25753668_ChIP-Seq_RAJI_Human1.06391673
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06382694
93* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.05630638
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04272601
95SOX2_16153702_ChIP-ChIP_HESCs_Human1.03636428
96GABP_19822575_ChIP-Seq_HepG2_Human0.99974298
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99249633
98XRN2_22483619_ChIP-Seq_HELA_Human0.98896790
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.98319356
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.98313708
101VDR_22108803_ChIP-Seq_LS180_Human0.98216481
102CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97426885
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95805693
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95442559
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95410384
106* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95137250
107IRF1_19129219_ChIP-ChIP_H3396_Human0.95120149
108ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95090103
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94955509
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.92529797
111* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.91888447
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91653462
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91192288
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90532907
115* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90291584
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88943172
117SCL_19346495_ChIP-Seq_HPC-7_Human0.88201029
118AR_21909140_ChIP-Seq_LNCAP_Human0.88097572
119VDR_21846776_ChIP-Seq_THP-1_Human0.88018560
120YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.87399255
121MYC_22102868_ChIP-Seq_BL_Human0.87068728
122* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87006886
123BCL6_27268052_Chip-Seq_Bcells_Human0.86970724
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86958844
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.86392728
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.85889310
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.85889310
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84628268
129ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83429426
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83246384
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.82667073
132EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.81516187
133CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81047143
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.80053017
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79847729
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.79207538
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.79085097
138PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78825735
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78780705
140ELF1_20517297_ChIP-Seq_JURKAT_Human0.77076015
141TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77022520
142PHF8_20622854_ChIP-Seq_HELA_Human0.76597723
143KDM5A_27292631_Chip-Seq_BREAST_Human0.76257518
144SPI1_20517297_ChIP-Seq_HL60_Human0.75566463
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.75407535
146SPI1_23547873_ChIP-Seq_NB4_Human0.73029864
147TET1_21451524_ChIP-Seq_MESCs_Mouse0.72661522
148CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.71976487
149MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71832812
150CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.71692150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.51230643
2MP0002837_dystrophic_cardiac_calcinosis4.33057479
3MP0005360_urolithiasis4.06483880
4MP0003806_abnormal_nucleotide_metabolis4.03173140
5MP0005085_abnormal_gallbladder_physiolo3.77878142
6MP0008058_abnormal_DNA_repair3.76554425
7MP0005365_abnormal_bile_salt3.59226656
8MP0010094_abnormal_chromosome_stability3.42498249
9MP0003693_abnormal_embryo_hatching3.39212341
10MP0003646_muscle_fatigue3.06273455
11MP0006036_abnormal_mitochondrial_physio3.01432526
12MP0004084_abnormal_cardiac_muscle2.97213654
13MP0003111_abnormal_nucleus_morphology2.74957090
14MP0004130_abnormal_muscle_cell2.70554912
15MP0010329_abnormal_lipoprotein_level2.63099246
16MP0005670_abnormal_white_adipose2.56709224
17MP0008875_abnormal_xenobiotic_pharmacok2.54119057
18MP0004215_abnormal_myocardial_fiber2.51281549
19MP0005330_cardiomyopathy2.51157344
20MP0008877_abnormal_DNA_methylation2.36478526
21MP0005332_abnormal_amino_acid2.31262139
22MP0004957_abnormal_blastocyst_morpholog2.24788213
23MP0006292_abnormal_olfactory_placode2.20250889
24MP0001529_abnormal_vocalization2.17869036
25MP0004036_abnormal_muscle_relaxation2.16019349
26MP0006035_abnormal_mitochondrial_morpho2.12102533
27MP0000749_muscle_degeneration2.05734999
28MP0003077_abnormal_cell_cycle1.96507352
29MP0003787_abnormal_imprinting1.95688575
30MP0003191_abnormal_cellular_cholesterol1.91517128
31MP0008932_abnormal_embryonic_tissue1.89651222
32MP0003252_abnormal_bile_duct1.89230359
33MP0002118_abnormal_lipid_homeostasis1.86474243
34MP0003724_increased_susceptibility_to1.82505499
35MP0002736_abnormal_nociception_after1.80978712
36MP0003786_premature_aging1.78830918
37MP0003221_abnormal_cardiomyocyte_apopto1.77748821
38MP0005319_abnormal_enzyme/_coenzyme1.76759997
39MP0000609_abnormal_liver_physiology1.73638469
40MP0002938_white_spotting1.73303848
41MP0009840_abnormal_foam_cell1.73027733
42MP0003123_paternal_imprinting1.72958182
43MP0000751_myopathy1.71537971
44MP0005666_abnormal_adipose_tissue1.71344343
45MP0003718_maternal_effect1.70066929
46MP0005584_abnormal_enzyme/coenzyme_acti1.69752564
47MP0001764_abnormal_homeostasis1.68693044
48MP0003186_abnormal_redox_activity1.68576908
49MP0002102_abnormal_ear_morphology1.68274538
50MP0005083_abnormal_biliary_tract1.68100186
51MP0001968_abnormal_touch/_nociception1.66127030
52MP0003121_genomic_imprinting1.65141927
53MP0003880_abnormal_central_pattern1.61014103
54MP0003656_abnormal_erythrocyte_physiolo1.60722090
55MP0008995_early_reproductive_senescence1.56836481
56MP0005645_abnormal_hypothalamus_physiol1.55380287
57MP0003122_maternal_imprinting1.54797999
58MP0002972_abnormal_cardiac_muscle1.54029603
59MP0004147_increased_porphyrin_level1.52963504
60MP0003195_calcinosis1.51180655
61MP0001544_abnormal_cardiovascular_syste1.50057988
62MP0005385_cardiovascular_system_phenoty1.50057988
63MP0005266_abnormal_metabolism1.48094021
64MP0008775_abnormal_heart_ventricle1.42912429
65MP0002653_abnormal_ependyma_morphology1.42346872
66MP0001666_abnormal_nutrient_absorption1.41509124
67MP0002269_muscular_atrophy1.41060725
68MP0008007_abnormal_cellular_replicative1.40136756
69MP0009046_muscle_twitch1.39515935
70MP0004859_abnormal_synaptic_plasticity1.39026709
71MP0006276_abnormal_autonomic_nervous1.38649744
72MP0004087_abnormal_muscle_fiber1.34194491
73MP0004133_heterotaxia1.32182285
74MP0001835_abnormal_antigen_presentation1.30484978
75MP0000372_irregular_coat_pigmentation1.30466391
76MP0002332_abnormal_exercise_endurance1.28431088
77MP0009697_abnormal_copulation1.27951205
78MP0004145_abnormal_muscle_electrophysio1.27660058
79MP0008872_abnormal_physiological_respon1.27339853
80MP0003137_abnormal_impulse_conducting1.27326903
81MP0002078_abnormal_glucose_homeostasis1.25151359
82MP0009643_abnormal_urine_homeostasis1.24382126
83MP0006072_abnormal_retinal_apoptosis1.24364037
84MP0008789_abnormal_olfactory_epithelium1.24217509
85MP0005499_abnormal_olfactory_system1.23910348
86MP0005394_taste/olfaction_phenotype1.23910348
87MP0005551_abnormal_eye_electrophysiolog1.23478653
88MP0002971_abnormal_brown_adipose1.22874441
89MP0002210_abnormal_sex_determination1.21137172
90MP0009672_abnormal_birth_weight1.20480318
91MP0005535_abnormal_body_temperature1.20260907
92MP0008057_abnormal_DNA_replication1.18025568
93MP0002138_abnormal_hepatobiliary_system1.17954598
94MP0005620_abnormal_muscle_contractility1.17437369
95MP0010630_abnormal_cardiac_muscle1.14985915
96MP0001984_abnormal_olfaction1.12873068
97MP0001929_abnormal_gametogenesis1.12842954
98MP0006138_congestive_heart_failure1.12693150
99MP0005375_adipose_tissue_phenotype1.11856972
100MP0000750_abnormal_muscle_regeneration1.10562387
101MP0008469_abnormal_protein_level1.09457971
102MP0009745_abnormal_behavioral_response1.09251177
103MP0003828_pulmonary_edema1.08034462
104MP0003119_abnormal_digestive_system1.07344110
105MP0005376_homeostasis/metabolism_phenot1.04359842
106MP0002272_abnormal_nervous_system1.04213894
107MP0003567_abnormal_fetal_cardiomyocyte1.03220845
108MP0001485_abnormal_pinna_reflex1.03188704
109MP0000598_abnormal_liver_morphology1.02788116
110MP0005451_abnormal_body_composition1.02101098
111MP0001730_embryonic_growth_arrest1.01799416
112MP0003698_abnormal_male_reproductive1.01758263
113MP0002822_catalepsy1.01486395
114MP0005334_abnormal_fat_pad1.00603801
115MP0001293_anophthalmia1.00092593
116MP0002734_abnormal_mechanical_nocicepti0.99147069
117MP0001145_abnormal_male_reproductive0.98060753
118MP0000631_abnormal_neuroendocrine_gland0.97362778
119MP0002106_abnormal_muscle_physiology0.96726532
120MP0004085_abnormal_heartbeat0.96452005
121MP0004270_analgesia0.96190756
122MP0003635_abnormal_synaptic_transmissio0.96085224
123MP0002163_abnormal_gland_morphology0.95814041
124MP0000747_muscle_weakness0.95709785
125MP0005423_abnormal_somatic_nervous0.95505987
126MP0009763_increased_sensitivity_to0.95211211
127MP0001986_abnormal_taste_sensitivity0.95035029
128MP0000653_abnormal_sex_gland0.92820562
129MP0005058_abnormal_lysosome_morphology0.92633206
130MP0003890_abnormal_embryonic-extraembry0.92558632
131MP0002160_abnormal_reproductive_system0.91901784
132MP0003950_abnormal_plasma_membrane0.91294493
133MP0005646_abnormal_pituitary_gland0.91228739
134MP0004043_abnormal_pH_regulation0.88809455
135MP0005448_abnormal_energy_balance0.88337321
136MP0002064_seizures0.88203494
137MP0004510_myositis0.87356437
138MP0001697_abnormal_embryo_size0.87340910
139MP0002234_abnormal_pharynx_morphology0.86878733
140MP0005220_abnormal_exocrine_pancreas0.85624294
141MP0004742_abnormal_vestibular_system0.85058553
142MP0009642_abnormal_blood_homeostasis0.84821499
143MP0002970_abnormal_white_adipose0.84298306
144MP0002557_abnormal_social/conspecific_i0.83777784
145MP0001853_heart_inflammation0.83602390
146MP0005671_abnormal_response_to0.82826342
147MP0001346_abnormal_lacrimal_gland0.82023985
148MP0005253_abnormal_eye_physiology0.81678671
149MP0004142_abnormal_muscle_tone0.80731402
150MP0001905_abnormal_dopamine_level0.80066223
151MP0003136_yellow_coat_color0.79747878
152MP0002638_abnormal_pupillary_reflex0.79056177
153MP0003690_abnormal_glial_cell0.78679063
154MP0004484_altered_response_of0.76727060
155MP0002735_abnormal_chemical_nociception0.76616564
156MP0003937_abnormal_limbs/digits/tail_de0.76184614
157MP0005380_embryogenesis_phenotype0.75166694
158MP0001672_abnormal_embryogenesis/_devel0.75166694
159MP0000778_abnormal_nervous_system0.74914574
160MP0000230_abnormal_systemic_arterial0.74623002
161MP0002080_prenatal_lethality0.74234154
162MP0000003_abnormal_adipose_tissue0.73786620
163MP0002067_abnormal_sensory_capabilities0.73027490
164MP0004185_abnormal_adipocyte_glucose0.72958685
165MP0009115_abnormal_fat_cell0.72611869
166MP0005389_reproductive_system_phenotype0.72468677
167MP0000955_abnormal_spinal_cord0.71989492
168MP0000313_abnormal_cell_death0.71550918
169MP0000343_altered_response_to0.71435557
170MP0004019_abnormal_vitamin_homeostasis0.71256461
171MP0003938_abnormal_ear_development0.70733810
172MP0009764_decreased_sensitivity_to0.70375102
173MP0002876_abnormal_thyroid_physiology0.68480276
174MP0002254_reproductive_system_inflammat0.67957216
175MP0005408_hypopigmentation0.67389061
176MP0001756_abnormal_urination0.66838823
177MP0002127_abnormal_cardiovascular_syste0.66812391
178MP0009785_altered_susceptibility_to0.66676364
179MP0005025_abnormal_response_to0.66553530
180MP0005636_abnormal_mineral_homeostasis0.66455268
181MP0000759_abnormal_skeletal_muscle0.62744159
182MP0005369_muscle_phenotype0.61744674
183MP0008873_increased_physiological_sensi0.61435857
184MP0000358_abnormal_cell_content/0.60569860
185MP0000604_amyloidosis0.60427489

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.01309864
2* Hepatic necrosis (HP:0002605)4.69016512
3Abnormality of fatty-acid metabolism (HP:0004359)4.57074526
4Generalized aminoaciduria (HP:0002909)4.30000928
5Ketosis (HP:0001946)4.22387885
6Myoglobinuria (HP:0002913)4.15504117
7* Cerebral edema (HP:0002181)4.03756468
8* Abnormal mitochondria in muscle tissue (HP:0008316)3.99450412
9Hyperammonemia (HP:0001987)3.93951451
10* Acute encephalopathy (HP:0006846)3.91682001
11* Hepatocellular necrosis (HP:0001404)3.88675145
12Ketoacidosis (HP:0001993)3.85410339
13Abnormality of dicarboxylic acid metabolism (HP:0010995)3.80728591
14Dicarboxylic aciduria (HP:0003215)3.80728591
15* Acute necrotizing encephalopathy (HP:0006965)3.79627869
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.77573823
17Hyperglycinuria (HP:0003108)3.64436491
18Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58781574
19Rhabdomyolysis (HP:0003201)3.48161088
20Abnormality of the labia minora (HP:0012880)3.46835519
21Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41673130
22* Lactic acidosis (HP:0003128)3.39525263
23* Increased CSF lactate (HP:0002490)3.36939434
24Increased muscle lipid content (HP:0009058)3.34316478
25Abnormality of glycine metabolism (HP:0010895)3.31509892
26Abnormality of serine family amino acid metabolism (HP:0010894)3.31509892
27Palpitations (HP:0001962)3.28083148
28Increased serum pyruvate (HP:0003542)3.24338523
29Abnormality of glycolysis (HP:0004366)3.24338523
30* Mitochondrial inheritance (HP:0001427)3.23595978
31Chromsome breakage (HP:0040012)3.15757671
32Xanthomatosis (HP:0000991)3.12615758
33* Lethargy (HP:0001254)3.11247792
34Abnormality of alanine metabolism (HP:0010916)3.08929755
35Hyperalaninemia (HP:0003348)3.08929755
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.08929755
37Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06413111
38Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06413111
39Renal cortical cysts (HP:0000803)3.05555726
40Hypobetalipoproteinemia (HP:0003563)3.04013870
41Intrahepatic cholestasis (HP:0001406)3.01898800
42Metabolic acidosis (HP:0001942)2.97346788
43Colon cancer (HP:0003003)2.96993781
44Meckel diverticulum (HP:0002245)2.95608175
45* Progressive macrocephaly (HP:0004481)2.94916551
46Ventricular tachycardia (HP:0004756)2.90751377
47Exercise-induced muscle cramps (HP:0003710)2.90068009
48Abnormality of the ileum (HP:0001549)2.89462232
49Hyperlipoproteinemia (HP:0010980)2.89034274
50Increased intramyocellular lipid droplets (HP:0012240)2.88042063
51Cerebral hypomyelination (HP:0006808)2.87454346
52Exercise-induced myalgia (HP:0003738)2.86129160
53Sudden death (HP:0001699)2.86008433
54Hyperglycinemia (HP:0002154)2.85911090
55Reticulocytopenia (HP:0001896)2.84483419
56* Increased serum lactate (HP:0002151)2.78282499
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.75198180
58Prolonged partial thromboplastin time (HP:0003645)2.74530641
59Ependymoma (HP:0002888)2.72969981
60Deep venous thrombosis (HP:0002625)2.64900396
61Lipoatrophy (HP:0100578)2.64876541
62Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61769970
63Hypoglycemic seizures (HP:0002173)2.61342746
64Neuroendocrine neoplasm (HP:0100634)2.60290469
65Nausea (HP:0002018)2.59979515
66Abnormality of the preputium (HP:0100587)2.59776551
67Abnormality of serum amino acid levels (HP:0003112)2.59435915
68* Vomiting (HP:0002013)2.56805449
69Ragged-red muscle fibers (HP:0003200)2.56290237
70Lipid accumulation in hepatocytes (HP:0006561)2.56195615
71* Respiratory failure (HP:0002878)2.50486087
72* Exercise intolerance (HP:0003546)2.50292083
73Hyperinsulinemic hypoglycemia (HP:0000825)2.49903325
74Acute hepatic failure (HP:0006554)2.49475645
75Proximal tubulopathy (HP:0000114)2.48618385
76Hypolipoproteinemia (HP:0010981)2.43409244
77Abnormal number of erythroid precursors (HP:0012131)2.43003729
78Dilated cardiomyopathy (HP:0001644)2.41559858
79Cholecystitis (HP:0001082)2.40986154
80Abnormal gallbladder physiology (HP:0012438)2.40986154
81Abnormality of the common coagulation pathway (HP:0010990)2.40952155
82Glycosuria (HP:0003076)2.39474251
83Abnormality of urine glucose concentration (HP:0011016)2.39474251
84Pheochromocytoma (HP:0002666)2.35250613
85Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34669468
86Atrial fibrillation (HP:0005110)2.33820200
87Asymmetric septal hypertrophy (HP:0001670)2.29102028
88Conjunctival hamartoma (HP:0100780)2.27793111
89Hyperbilirubinemia (HP:0002904)2.26704129
90Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26584160
91Abnormality of chromosome stability (HP:0003220)2.25243292
92* Leukodystrophy (HP:0002415)2.24545673
93Delayed CNS myelination (HP:0002188)2.24160784
94Abnormality of cells of the erythroid lineage (HP:0012130)2.23429062
95Esophageal neoplasm (HP:0100751)2.22131162
96Neoplasm of head and neck (HP:0012288)2.22131162
97Abnormality of methionine metabolism (HP:0010901)2.21594375
98Horseshoe kidney (HP:0000085)2.21340897
99Type I transferrin isoform profile (HP:0003642)2.20676261
100Progressive microcephaly (HP:0000253)2.19849588
101* CNS demyelination (HP:0007305)2.19348629
102Absent thumb (HP:0009777)2.19233109
103Hypoalphalipoproteinemia (HP:0003233)2.17745664
104Complement deficiency (HP:0004431)2.13052707
105Small intestinal stenosis (HP:0012848)2.11149112
106Duodenal stenosis (HP:0100867)2.11149112
107Cholelithiasis (HP:0001081)2.11016630
108Microvesicular hepatic steatosis (HP:0001414)2.10449720
109Neoplasm of the adrenal gland (HP:0100631)2.10091542
110Supraventricular tachycardia (HP:0004755)2.09408369
111Abnormality of sulfur amino acid metabolism (HP:0004339)2.09181699
112Primary atrial arrhythmia (HP:0001692)2.07556364
113Abnormal gallbladder morphology (HP:0012437)2.06227877
114Renal Fanconi syndrome (HP:0001994)2.04313992
115Increased hepatocellular lipid droplets (HP:0006565)2.03700675
116Supraventricular arrhythmia (HP:0005115)2.01716645
117Joint hemorrhage (HP:0005261)2.01692337
118Abnormal protein glycosylation (HP:0012346)1.99666526
119Abnormal glycosylation (HP:0012345)1.99666526
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99666526
121Abnormal protein N-linked glycosylation (HP:0012347)1.99666526
122Bundle branch block (HP:0011710)1.99395557
1233-Methylglutaconic aciduria (HP:0003535)1.97400889
124CNS hypomyelination (HP:0003429)1.96098851
125Abnormality of the carotid arteries (HP:0005344)1.95499999
126Retinal dysplasia (HP:0007973)1.95376393
127Abnormality of pyrimidine metabolism (HP:0004353)1.95143858
128Hypoplasia of the pons (HP:0012110)1.95068566
129Elevated hepatic transaminases (HP:0002910)1.94925824
130* Gliosis (HP:0002171)1.94531693
131Epidermoid cyst (HP:0200040)1.93910493
132Abnormality of the anterior horn cell (HP:0006802)1.93269939
133Degeneration of anterior horn cells (HP:0002398)1.93269939
134Abnormality of the intrinsic pathway (HP:0010989)1.92907935
135* Optic disc pallor (HP:0000543)1.91196620
136Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.90818043
137Abnormality of the duodenum (HP:0002246)1.90454943
138Syncope (HP:0001279)1.90343395
139Birth length less than 3rd percentile (HP:0003561)1.90164352
140Abnormality of the astrocytes (HP:0100707)1.85308971
141Astrocytoma (HP:0009592)1.85308971
142Methylmalonic aciduria (HP:0012120)1.84593461
143Triphalangeal thumb (HP:0001199)1.84344680
144Sloping forehead (HP:0000340)1.81351948
145Abnormality of cochlea (HP:0000375)1.80913461
146* Emotional lability (HP:0000712)1.79650216
147Abnormal lung lobation (HP:0002101)1.79542404
148Multiple enchondromatosis (HP:0005701)1.79139023
149Patellar aplasia (HP:0006443)1.78026240
150Type II lissencephaly (HP:0007260)1.75495468
151Poor suck (HP:0002033)1.75056587
152Abnormality of DNA repair (HP:0003254)1.74397443
153Abnormality of the pons (HP:0007361)1.74008988
154Myokymia (HP:0002411)1.73327009
155Glioma (HP:0009733)1.71427449
156Aplasia/Hypoplasia of the patella (HP:0006498)1.71252493
157Pancytopenia (HP:0001876)1.66419015
158Molar tooth sign on MRI (HP:0002419)1.65543244
159Abnormality of midbrain morphology (HP:0002418)1.65543244
160Methylmalonic acidemia (HP:0002912)1.64549675
161Delayed myelination (HP:0012448)1.63758146
162Abnormality of reticulocytes (HP:0004312)1.63179819
163Sclerocornea (HP:0000647)1.62874334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.33597601
2VRK24.57243741
3TIE14.07762863
4FGFR43.92580064
5SRPK13.43276768
6CDC73.29578969
7PKN23.26902136
8INSRR2.99187426
9PDK32.95284869
10PDK42.95284869
11TRIM282.83180367
12NME12.46388258
13ERN12.38120902
14FLT32.36419869
15OBSCN2.34474550
16TTK2.28586222
17MYLK2.28532713
18WNK32.17019571
19MAP4K12.13406791
20PDK22.13329112
21TTN2.06331705
22PBK2.02851090
23VRK12.02006479
24TGFBR22.01748256
25NUAK11.94082278
26MAP4K21.87937067
27WEE11.86861395
28NME21.78021375
29FGFR21.77622762
30TYK21.77267790
31PLK31.76787230
32PASK1.71065433
33LMTK21.60765869
34DYRK21.56431232
35NEK11.55710377
36SIK21.54037751
37PINK11.51874535
38PLK11.49561480
39MAPK111.44750020
40BRSK11.42120692
41EIF2AK31.40331946
42KDR1.39402919
43KIT1.34762434
44IRAK31.29302067
45PLK41.25273928
46EIF2AK11.24128232
47WNK41.23822892
48PHKG21.23485389
49PHKG11.23485389
50TRIB31.22033245
51CASK1.19990746
52CSNK1G31.17407738
53SIK11.17281254
54TXK1.12892410
55MUSK1.12662701
56CHEK21.09934472
57DAPK11.09143246
58FGFR31.08203670
59ACVR1B1.07720584
60JAK11.07041781
61TBK11.04999840
62EPHA41.03370851
63ZAK1.03017696
64RIPK41.01604353
65NEK20.95110411
66BRAF0.93922869
67TSSK60.93232108
68CCNB10.90345162
69CSNK1G10.90083431
70CSNK1G20.89605477
71TGFBR10.89426969
72MKNK20.88389488
73MAP3K40.87342215
74MAPK120.86456508
75CSF1R0.85879666
76TAF10.84606572
77JAK30.84371410
78IKBKE0.82962410
79AURKA0.82260927
80PLK20.82165706
81CSNK1A1L0.81913247
82AURKB0.81468441
83PRKCI0.80987733
84SYK0.80102218
85CDK190.79937512
86MAPK130.79455360
87MAPKAPK50.78466379
88ITK0.77717182
89CHEK10.77428036
90BCR0.76183669
91RPS6KL10.76144601
92RPS6KC10.76144601
93JAK20.75892546
94PRKCG0.75104994
95CDK40.74877862
96ATM0.73338398
97PRKD30.71274343
98MINK10.69848250
99PDK10.69715134
100MKNK10.67237563
101MAP3K70.66810355
102FRK0.66713987
103RPS6KA60.66364851
104SMG10.65930484
105MAP2K70.65709190
106ALK0.65131818
107PRKAA10.62869908
108PNCK0.62281083
109MAPKAPK30.60757589
110OXSR10.60506772
111PRKAA20.60223114
112PIK3CA0.59903718
113CSNK2A20.58759666
114GRK10.58452784
115LRRK20.58272357
116BMPR1B0.57057329
117LIMK10.55609183
118ZAP700.55584125
119CSNK1E0.55190879
120CDK10.53116854
121CSNK2A10.53059546
122TLK10.51863555
123CDK70.49900120
124LYN0.49846831
125PRKACG0.49084754
126PRKDC0.48577048
127TEC0.48382594
128PIM20.48050132
129PKN10.48013319
130CAMK40.47986072
131PRKD10.47682479
132YES10.47008426
133CDK20.46820011
134LCK0.44538166
135RPS6KA50.42585879
136BUB10.42369244
137NTRK30.42084169
138SIK30.41680419
139BTK0.41536145
140TESK20.41516401
141AKT20.41081397
142MST40.41062236
143CDK140.40871222
144CDK11A0.40722266
145CDK180.39929501
146STK40.39242666
147PIK3CG0.39050951
148CDK150.38112500
149ICK0.38091055
150CAMK1D0.37791714
151CSNK1A10.37389476
152PRKCQ0.37341843
153STK160.37181745
154MAPK40.36183467
155NEK90.36080975
156MARK10.35964482
157ERBB40.34734672
158GRK70.33605828
159MAP3K50.33315287
160FGFR10.32550553
161MAP3K140.31281073
162PDPK10.30854955
163TNIK0.30468873
164SCYL20.30342279
165CAMK2G0.30175903
166BRSK20.29003244
167PRKCH0.28106469
168ATR0.27434648
169STK100.27108754
170GRK60.27091945
171RPS6KB10.26913427
172PRKCD0.25242266
173DAPK30.25178249
174EIF2AK20.24430545
175RPS6KA20.22983871

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.77587482
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.81611181
3Propanoate metabolism_Homo sapiens_hsa006403.79119273
4Fatty acid degradation_Homo sapiens_hsa000713.38001476
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29560570
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.15710837
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98733292
8Fatty acid metabolism_Homo sapiens_hsa012122.68974354
9Carbon metabolism_Homo sapiens_hsa012002.58771076
10Homologous recombination_Homo sapiens_hsa034402.46643749
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.44183503
12Pyruvate metabolism_Homo sapiens_hsa006202.43170615
13Butanoate metabolism_Homo sapiens_hsa006502.23933601
14RNA polymerase_Homo sapiens_hsa030202.20836067
15Peroxisome_Homo sapiens_hsa041462.11598970
16Tryptophan metabolism_Homo sapiens_hsa003802.10742649
17Fanconi anemia pathway_Homo sapiens_hsa034602.10538118
18Ribosome_Homo sapiens_hsa030102.09051574
19Fatty acid elongation_Homo sapiens_hsa000622.04761812
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00754739
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93087369
22Arginine biosynthesis_Homo sapiens_hsa002201.90435199
23Oxidative phosphorylation_Homo sapiens_hsa001901.88828917
24Biosynthesis of amino acids_Homo sapiens_hsa012301.81917588
25Parkinsons disease_Homo sapiens_hsa050121.81619324
26PPAR signaling pathway_Homo sapiens_hsa033201.81041632
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78340435
28Non-homologous end-joining_Homo sapiens_hsa034501.77663320
29beta-Alanine metabolism_Homo sapiens_hsa004101.69349572
30Spliceosome_Homo sapiens_hsa030401.62091850
31RNA transport_Homo sapiens_hsa030131.53473883
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53416215
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51694592
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47696648
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45735060
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34820908
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.33239851
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32952524
39Selenocompound metabolism_Homo sapiens_hsa004501.32921333
40Phenylalanine metabolism_Homo sapiens_hsa003601.28463361
41Nitrogen metabolism_Homo sapiens_hsa009101.26483986
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26273695
43RNA degradation_Homo sapiens_hsa030181.26269143
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.25252504
45Basal transcription factors_Homo sapiens_hsa030221.18365993
46Caffeine metabolism_Homo sapiens_hsa002321.18022592
47Complement and coagulation cascades_Homo sapiens_hsa046101.15486987
48Alzheimers disease_Homo sapiens_hsa050101.15318316
49Cardiac muscle contraction_Homo sapiens_hsa042601.12194914
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10714691
51Pentose phosphate pathway_Homo sapiens_hsa000301.09910896
52Starch and sucrose metabolism_Homo sapiens_hsa005001.09226263
53Pentose and glucuronate interconversions_Homo sapiens_hsa000401.08475478
54Huntingtons disease_Homo sapiens_hsa050161.02977765
55One carbon pool by folate_Homo sapiens_hsa006701.02003097
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.99321818
57Tyrosine metabolism_Homo sapiens_hsa003500.96964333
58Cell cycle_Homo sapiens_hsa041100.94093623
59Sulfur metabolism_Homo sapiens_hsa009200.87310389
60Staphylococcus aureus infection_Homo sapiens_hsa051500.82584097
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81841812
62ABC transporters_Homo sapiens_hsa020100.81565579
63Lysine degradation_Homo sapiens_hsa003100.81424964
64Proteasome_Homo sapiens_hsa030500.79465158
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79390360
66Folate biosynthesis_Homo sapiens_hsa007900.78411639
67N-Glycan biosynthesis_Homo sapiens_hsa005100.78016702
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77178848
69Fatty acid biosynthesis_Homo sapiens_hsa000610.76347402
70Arginine and proline metabolism_Homo sapiens_hsa003300.76218914
71Metabolic pathways_Homo sapiens_hsa011000.71899492
72Insulin resistance_Homo sapiens_hsa049310.71471028
73mRNA surveillance pathway_Homo sapiens_hsa030150.71446048
74Nicotine addiction_Homo sapiens_hsa050330.66318267
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.65809382
76Histidine metabolism_Homo sapiens_hsa003400.64910569
77Vitamin B6 metabolism_Homo sapiens_hsa007500.63205790
78Chemical carcinogenesis_Homo sapiens_hsa052040.59972507
79Galactose metabolism_Homo sapiens_hsa000520.57652012
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.57552694
81Phototransduction_Homo sapiens_hsa047440.57362082
82Fructose and mannose metabolism_Homo sapiens_hsa000510.56873753
83Fat digestion and absorption_Homo sapiens_hsa049750.56685881
84Oocyte meiosis_Homo sapiens_hsa041140.55633443
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55509885
86Glycerolipid metabolism_Homo sapiens_hsa005610.55236928
87DNA replication_Homo sapiens_hsa030300.50370933
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.49590851
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47935824
90Sulfur relay system_Homo sapiens_hsa041220.46336899
91Collecting duct acid secretion_Homo sapiens_hsa049660.46298966
92Retinol metabolism_Homo sapiens_hsa008300.45649658
93Synaptic vesicle cycle_Homo sapiens_hsa047210.45570885
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44439642
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.44213629
96Glutathione metabolism_Homo sapiens_hsa004800.42551315
97Bile secretion_Homo sapiens_hsa049760.40888122
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37920634
99Glucagon signaling pathway_Homo sapiens_hsa049220.37218953
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34872751
101Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34860348
102Pyrimidine metabolism_Homo sapiens_hsa002400.32959943
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32306652
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31590878
105Vitamin digestion and absorption_Homo sapiens_hsa049770.31432472
106Linoleic acid metabolism_Homo sapiens_hsa005910.30116526
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29301426
108AMPK signaling pathway_Homo sapiens_hsa041520.27800098
109Dilated cardiomyopathy_Homo sapiens_hsa054140.27620723
110Mismatch repair_Homo sapiens_hsa034300.25998693
111Taste transduction_Homo sapiens_hsa047420.25470971
112Insulin signaling pathway_Homo sapiens_hsa049100.23359968
113Regulation of autophagy_Homo sapiens_hsa041400.23241434
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22311643
115Legionellosis_Homo sapiens_hsa051340.20460663
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20003967
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19410380
118Base excision repair_Homo sapiens_hsa034100.15315898
119Steroid biosynthesis_Homo sapiens_hsa001000.14374126
120Protein export_Homo sapiens_hsa030600.10906547
121Nucleotide excision repair_Homo sapiens_hsa034200.08995557
122Primary immunodeficiency_Homo sapiens_hsa053400.08155440
123Purine metabolism_Homo sapiens_hsa002300.06028498
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02727940
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.02116819

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