FOXO6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.25246479
2acrosome reaction (GO:0007340)5.21829512
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.85599181
4sperm motility (GO:0030317)4.82907325
5synaptic vesicle maturation (GO:0016188)4.78613557
6chromosome condensation (GO:0030261)4.65908711
7vocalization behavior (GO:0071625)4.58721974
8regulation of synapse structural plasticity (GO:0051823)4.57797300
9DNA packaging (GO:0006323)4.39047669
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.37251588
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.33966974
12fusion of sperm to egg plasma membrane (GO:0007342)4.29515383
13dendritic spine morphogenesis (GO:0060997)4.26487260
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.22781090
15microtubule depolymerization (GO:0007019)4.22415013
16protein localization to synapse (GO:0035418)4.08785034
17locomotory exploration behavior (GO:0035641)4.06804377
18synaptic vesicle exocytosis (GO:0016079)4.02329081
19microtubule severing (GO:0051013)3.95827687
20regulation of glutamate receptor signaling pathway (GO:1900449)3.88797213
21detection of calcium ion (GO:0005513)3.86341602
22axonal fasciculation (GO:0007413)3.85443266
23sperm capacitation (GO:0048240)3.83546226
24neuron recognition (GO:0008038)3.83104138
25neuron cell-cell adhesion (GO:0007158)3.81977739
26glutamate secretion (GO:0014047)3.80017802
27outflow tract septum morphogenesis (GO:0003148)3.79374793
28positive regulation of synapse maturation (GO:0090129)3.77190762
29response to pheromone (GO:0019236)3.73387969
30regulation of neuronal synaptic plasticity (GO:0048168)3.70131043
31adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.70110098
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.68964484
33cell migration in hindbrain (GO:0021535)3.61256603
34activation of protein kinase A activity (GO:0034199)3.59173049
35central nervous system projection neuron axonogenesis (GO:0021952)3.59042608
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.58520766
37single strand break repair (GO:0000012)3.58036942
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.56809504
39regulation of female receptivity (GO:0045924)3.54272225
40dendrite morphogenesis (GO:0048813)3.53976328
41protein-DNA complex disassembly (GO:0032986)3.49797559
42nucleosome disassembly (GO:0006337)3.49797559
43exploration behavior (GO:0035640)3.46491595
44microtubule polymerization or depolymerization (GO:0031109)3.45970872
45pyrimidine nucleobase catabolic process (GO:0006208)3.37912331
46synaptic transmission, glutamatergic (GO:0035249)3.37725553
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.37032730
48regulation of dendritic spine morphogenesis (GO:0061001)3.36808336
49calcium ion-dependent exocytosis (GO:0017156)3.36082161
50regulation of synaptic vesicle exocytosis (GO:2000300)3.36008601
51spermatid development (GO:0007286)3.32622699
52establishment of nucleus localization (GO:0040023)3.30175480
53regulation of somitogenesis (GO:0014807)3.28571145
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26888987
55postsynaptic membrane organization (GO:0001941)3.25831973
56plasma membrane fusion (GO:0045026)3.23148393
57establishment of apical/basal cell polarity (GO:0035089)3.22856879
58cranial nerve morphogenesis (GO:0021602)3.17258491
59dendritic spine organization (GO:0097061)3.17087680
60protein polyglutamylation (GO:0018095)3.17048773
61regulation of transcription involved in cell fate commitment (GO:0060850)3.15214488
62RNA localization (GO:0006403)3.15083435
63muscle cell fate commitment (GO:0042693)3.13904471
64female mating behavior (GO:0060180)3.12968444
65establishment or maintenance of monopolar cell polarity (GO:0061339)3.11736881
66establishment of monopolar cell polarity (GO:0061162)3.11736881
67glutamate receptor signaling pathway (GO:0007215)3.10688686
68sensory perception of smell (GO:0007608)3.09857921
69auditory behavior (GO:0031223)3.09850096
70dopamine receptor signaling pathway (GO:0007212)3.09766335
71mitochondrion transport along microtubule (GO:0047497)3.09394650
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09394650
73synaptic vesicle endocytosis (GO:0048488)3.08828690
74musculoskeletal movement (GO:0050881)3.08067356
75multicellular organismal movement (GO:0050879)3.08067356
76regulation of synaptic vesicle transport (GO:1902803)3.07150072
77axon extension (GO:0048675)3.05239642
78innervation (GO:0060384)3.04830896
79glial cell proliferation (GO:0014009)3.01437523
80positive regulation of dendritic spine development (GO:0060999)3.01392092
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.98545717
82regulation of synaptic plasticity (GO:0048167)2.97804477
83neuron-neuron synaptic transmission (GO:0007270)2.96912910
84cell communication by electrical coupling (GO:0010644)2.95758522
85central nervous system neuron axonogenesis (GO:0021955)2.95125171
86rRNA methylation (GO:0031167)2.94713008
87establishment of mitochondrion localization (GO:0051654)2.93895199
88multicellular organism reproduction (GO:0032504)2.93562084
89chromatin silencing (GO:0006342)2.93121126
90planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93028338
91regulation of synapse maturation (GO:0090128)2.92945534
92sperm-egg recognition (GO:0035036)2.92361889
93membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.91362655
94tooth mineralization (GO:0034505)2.90414939
95long-term memory (GO:0007616)2.89096116
96pharyngeal system development (GO:0060037)2.87203339
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86574677
98gamma-aminobutyric acid transport (GO:0015812)2.86278285
99behavioral fear response (GO:0001662)2.84442696
100behavioral defense response (GO:0002209)2.84442696
101cerebral cortex radially oriented cell migration (GO:0021799)2.84430681
102regulation of postsynaptic membrane potential (GO:0060078)2.83780164
103protein retention in ER lumen (GO:0006621)2.83269097
104neuromuscular process controlling balance (GO:0050885)2.82893649
105proline transport (GO:0015824)2.82866814
106neurotransmitter secretion (GO:0007269)2.82163056
107regulation of dendritic spine development (GO:0060998)2.81357226
108chemosensory behavior (GO:0007635)2.81039474
109cerebellar Purkinje cell layer development (GO:0021680)2.79768162
110positive regulation of Rab GTPase activity (GO:0032851)2.79451848
111regulation of Rab GTPase activity (GO:0032313)2.79451848
112positive regulation of membrane potential (GO:0045838)2.78700877
113nucleobase catabolic process (GO:0046113)2.78580735
114spermatid nucleus differentiation (GO:0007289)2.77671932
115fear response (GO:0042596)2.77566413
116neurotransmitter-gated ion channel clustering (GO:0072578)2.76917443
117cerebellum development (GO:0021549)2.75306566
118cerebellar granule cell differentiation (GO:0021707)2.74987572
119neuron projection extension (GO:1990138)2.74880449
120cochlea morphogenesis (GO:0090103)2.74577077
121regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.74300770
122spermatogenesis (GO:0007283)2.74157008
123male gamete generation (GO:0048232)2.73165260
124organelle transport along microtubule (GO:0072384)2.72863651
125cell-cell junction maintenance (GO:0045217)2.71839601
126axonemal dynein complex assembly (GO:0070286)2.70718029
127synapse assembly (GO:0007416)2.70184314
128transmission of nerve impulse (GO:0019226)2.69545700
129positive regulation of axon extension (GO:0045773)2.68969508
130ephrin receptor signaling pathway (GO:0048013)2.68347368
131polarized epithelial cell differentiation (GO:0030859)2.67945340
132positive regulation of neurotransmitter secretion (GO:0001956)2.66538366
133response to auditory stimulus (GO:0010996)2.65903409
134motile cilium assembly (GO:0044458)2.65126578
135phosphatidylethanolamine biosynthetic process (GO:0006646)2.62291634
136inner ear receptor cell development (GO:0060119)2.61896381
137response to parathyroid hormone (GO:0071107)2.61841075
138regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.61213748
139regulation of mesenchymal cell apoptotic process (GO:2001053)2.61054506
140negative regulation of cell size (GO:0045792)2.60941650
141synapse organization (GO:0050808)2.60896278
142negative regulation of microtubule polymerization (GO:0031115)2.59630570
143body morphogenesis (GO:0010171)2.59473360
144reproduction (GO:0000003)2.59179477
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.58924137
146response to acidic pH (GO:0010447)2.58629358
147hippocampus development (GO:0021766)2.58459902
148cell communication involved in cardiac conduction (GO:0086065)2.58412651
149negative regulation of catenin import into nucleus (GO:0035414)2.57965864
150regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.57131122
151receptor recycling (GO:0001881)2.57091937
152regulation of cardioblast proliferation (GO:0003264)2.55379419
153regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55379419
154neuronal ion channel clustering (GO:0045161)2.55126640
155neuron fate specification (GO:0048665)2.54895485
156positive regulation of dendrite morphogenesis (GO:0050775)2.53681852
157cerebral cortex neuron differentiation (GO:0021895)2.53095840
158positive regulation of dendrite development (GO:1900006)2.52939646
159cellular response to glucagon stimulus (GO:0071377)2.52763563
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.52205293
161establishment of planar polarity (GO:0001736)2.50676401
162establishment of tissue polarity (GO:0007164)2.50676401
163intracellular estrogen receptor signaling pathway (GO:0030520)2.50279663
164rRNA modification (GO:0000154)2.50277460
165establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.49303454
166positive regulation of skeletal muscle tissue development (GO:0048643)2.47823458
167binding of sperm to zona pellucida (GO:0007339)2.47685160
168gamete generation (GO:0007276)2.47560028
169positive regulation of myotube differentiation (GO:0010831)2.47147720
170embryonic body morphogenesis (GO:0010172)2.46058607
171epithelial cell fate commitment (GO:0072148)2.41896520
172peptidyl-arginine omega-N-methylation (GO:0035247)2.41755186
173maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38909840
174cellular response to pH (GO:0071467)2.36548969
175skeletal muscle organ development (GO:0060538)2.36452065
176embryonic skeletal joint morphogenesis (GO:0060272)2.36146613
177spinal cord motor neuron differentiation (GO:0021522)2.31948774
178coronary vasculature morphogenesis (GO:0060977)2.31391204
179phosphatidylethanolamine metabolic process (GO:0046337)2.26599735
180regulation of mammary gland epithelial cell proliferation (GO:0033599)2.26534449
181negative regulation of Rho protein signal transduction (GO:0035024)2.26035751
182negative regulation of organelle assembly (GO:1902116)2.24433995
183negative regulation of inclusion body assembly (GO:0090084)2.23936096
184membrane protein intracellular domain proteolysis (GO:0031293)2.21789974
185negative regulation of Notch signaling pathway (GO:0045746)2.21592213
186negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.21338453
187regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.21330679
188regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.20139575
189cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.20032827
190peptidyl-arginine N-methylation (GO:0035246)2.18773754
191peptidyl-arginine methylation (GO:0018216)2.18773754
192negative regulation of embryonic development (GO:0045992)2.18188093
193atrioventricular valve morphogenesis (GO:0003181)2.15996142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.31759387
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.95762785
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95050224
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81231211
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.80357807
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78823101
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78823101
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.77404862
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65492735
10GBX2_23144817_ChIP-Seq_PC3_Human2.52010808
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.45884704
12* RNF2_27304074_Chip-Seq_ESCs_Mouse2.42133977
13* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40901877
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.38784945
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37953846
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36945727
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35529952
18DROSHA_22980978_ChIP-Seq_HELA_Human2.35073709
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34013894
20* REST_21632747_ChIP-Seq_MESCs_Mouse2.30139782
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29962484
22P68_20966046_ChIP-Seq_HELA_Human2.26876873
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25178039
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.21424892
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13505699
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07424333
27SMC4_20622854_ChIP-Seq_HELA_Human2.05758927
28RACK7_27058665_Chip-Seq_MCF-7_Human1.96531120
29* REST_18959480_ChIP-ChIP_MESCs_Mouse1.89731494
30TET1_21451524_ChIP-Seq_MESCs_Mouse1.87739136
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.87085733
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.85010650
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.81275049
34KDM2B_26808549_Chip-Seq_K562_Human1.72303522
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72016654
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71852457
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.67963588
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.66243513
39* RING1B_27294783_Chip-Seq_NPCs_Mouse1.61548693
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60833422
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59183246
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57915550
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.56281305
44RUNX1_27514584_Chip-Seq_MCF-7_Human1.55872860
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55214362
46E2F1_20622854_ChIP-Seq_HELA_Human1.54030835
47PHF8_20622854_ChIP-Seq_HELA_Human1.49440428
48MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45870764
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.44904677
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44348773
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.43905153
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42620407
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41127179
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40475737
55* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39296870
56UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37548940
57BCOR_27268052_Chip-Seq_Bcells_Human1.35128396
58* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34051858
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33052156
60* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32906281
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32226908
62TP63_22573176_ChIP-Seq_HFKS_Human1.31941292
63BCL6_27268052_Chip-Seq_Bcells_Human1.31687504
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.31048479
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31038741
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30991321
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30749888
68* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29493120
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.27915503
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.26024987
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25713567
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25482590
73ERA_21632823_ChIP-Seq_H3396_Human1.23209368
74TP53_20018659_ChIP-ChIP_R1E_Mouse1.22665074
75CTCF_27219007_Chip-Seq_Bcells_Human1.22558950
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.22059860
77AHR_22903824_ChIP-Seq_MCF-7_Human1.19243818
78SA1_27219007_Chip-Seq_Bcells_Human1.18354641
79AR_19668381_ChIP-Seq_PC3_Human1.18070151
80CTCF_20526341_ChIP-Seq_ESCs_Human1.17437443
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16204614
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15894329
83EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14977586
84SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14874080
85OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14617874
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14288726
87TP53_22127205_ChIP-Seq_IMR90_Human1.14164337
88SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13660562
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.13142757
90AR_21572438_ChIP-Seq_LNCaP_Human1.12779074
91PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12759609
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11819816
93RNF2_27304074_Chip-Seq_NSC_Mouse1.11731614
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11462691
95RARA_24833708_ChIP-Seq_LIVER_Mouse1.10877689
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10587895
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09750667
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09116484
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.08967971
100SMAD4_21799915_ChIP-Seq_A2780_Human1.08437537
101YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07987160
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07615081
103SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07611644
104ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07161595
105NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.07000652
106RAC3_21632823_ChIP-Seq_H3396_Human1.05672104
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05227972
108TDRD3_21172665_ChIP-Seq_MCF-7_Human1.04730187
109KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04241316
110RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04113903
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.03736004
112TCF7_22412390_ChIP-Seq_EML_Mouse1.02788660
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02533213
114JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01899391
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.01736419
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.01320728
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01269407
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01026928
119CTCF_21964334_Chip-Seq_Bcells_Human1.00904099
120WDR5_24793694_ChIP-Seq_LNCAP_Human0.99715776
121BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98730393
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98680658
123GATA1_26923725_Chip-Seq_HPCs_Mouse0.98606692
124TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96717420
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94998059
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94998059
127ZNF274_21170338_ChIP-Seq_K562_Hela0.94847971
128ZNF263_19887448_ChIP-Seq_K562_Human0.94742893
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94688322
130NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93737668
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.93636647
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.93188764
133STAT3_23295773_ChIP-Seq_U87_Human0.92386040
134SMAD3_21741376_ChIP-Seq_HESCs_Human0.92126447
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.91487982
136ISL1_27105846_Chip-Seq_CPCs_Mouse0.91308210
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.91040028
138SMAD3_21741376_ChIP-Seq_ESCs_Human0.90342856
139* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90281529
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87988293
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87835641
142SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87515793
143LXR_22292898_ChIP-Seq_THP-1_Human0.85413922
144NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84407167
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81357416
146CREB1_26743006_Chip-Seq_LNCaP_Human0.80912999
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79910858
148KDM2B_26808549_Chip-Seq_DND41_Human0.79530428
149KLF4_19829295_ChIP-Seq_ESCs_Human0.79152832
150OCT4_19829295_ChIP-Seq_ESCs_Human0.78850894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.61967421
2MP0004270_analgesia3.83581328
3MP0005410_abnormal_fertilization3.69654767
4MP0003635_abnormal_synaptic_transmissio3.36060212
5MP0002063_abnormal_learning/memory/cond2.93624992
6MP0003880_abnormal_central_pattern2.87212102
7MP0005377_hearing/vestibular/ear_phenot2.85986371
8MP0003878_abnormal_ear_physiology2.85986371
9MP0001984_abnormal_olfaction2.77059114
10MP0002249_abnormal_larynx_morphology2.60288433
11MP0000678_abnormal_parathyroid_gland2.56906589
12MP0000778_abnormal_nervous_system2.54539862
13MP0009780_abnormal_chondrocyte_physiolo2.52003891
14MP0004858_abnormal_nervous_system2.40847887
15MP0009745_abnormal_behavioral_response2.39890605
16MP0005670_abnormal_white_adipose2.38683164
17MP0002572_abnormal_emotion/affect_behav2.21061211
18MP0002734_abnormal_mechanical_nocicepti2.17099454
19MP0002909_abnormal_adrenal_gland2.12912510
20MP0002064_seizures2.06980987
21MP0005499_abnormal_olfactory_system2.01747452
22MP0005394_taste/olfaction_phenotype2.01747452
23MP0001486_abnormal_startle_reflex1.96529852
24MP0002184_abnormal_innervation1.92057756
25MP0000751_myopathy1.91879082
26MP0008789_abnormal_olfactory_epithelium1.82563973
27MP0001440_abnormal_grooming_behavior1.79885315
28MP0005423_abnormal_somatic_nervous1.76320596
29MP0002272_abnormal_nervous_system1.75147196
30MP0003698_abnormal_male_reproductive1.72754752
31MP0002557_abnormal_social/conspecific_i1.67299528
32MP0003283_abnormal_digestive_organ1.66158006
33MP0000534_abnormal_ureter_morphology1.66042449
34MP0000955_abnormal_spinal_cord1.64286016
35MP0002822_catalepsy1.62925818
36MP0009053_abnormal_anal_canal1.62357258
37MP0004885_abnormal_endolymph1.61548028
38MP0004811_abnormal_neuron_physiology1.60418226
39MP0002735_abnormal_chemical_nociception1.59808187
40MP0003123_paternal_imprinting1.53494716
41MP0002733_abnormal_thermal_nociception1.51926582
42MP0003787_abnormal_imprinting1.51290151
43MP0002882_abnormal_neuron_morphology1.51183139
44MP0003879_abnormal_hair_cell1.49269776
45MP0001968_abnormal_touch/_nociception1.48953553
46MP0000566_synostosis1.48589116
47MP0001970_abnormal_pain_threshold1.47992595
48MP0000631_abnormal_neuroendocrine_gland1.39128427
49MP0002234_abnormal_pharynx_morphology1.37064043
50MP0005187_abnormal_penis_morphology1.35632830
51MP0002152_abnormal_brain_morphology1.35270647
52MP0009046_muscle_twitch1.35081102
53MP0006276_abnormal_autonomic_nervous1.32942020
54MP0005645_abnormal_hypothalamus_physiol1.32270869
55MP0005623_abnormal_meninges_morphology1.29730594
56MP0004145_abnormal_muscle_electrophysio1.28073112
57MP0003119_abnormal_digestive_system1.26729595
58MP0001929_abnormal_gametogenesis1.25607580
59MP0002067_abnormal_sensory_capabilities1.24682661
60MP0003329_amyloid_beta_deposits1.23657773
61MP0003137_abnormal_impulse_conducting1.21515045
62MP0004924_abnormal_behavior1.19806434
63MP0005386_behavior/neurological_phenoty1.19806434
64MP0005646_abnormal_pituitary_gland1.19286750
65MP0003861_abnormal_nervous_system1.17187246
66MP0002066_abnormal_motor_capabilities/c1.15965629
67MP0001346_abnormal_lacrimal_gland1.14521748
68MP0005409_darkened_coat_color1.12527491
69MP0002161_abnormal_fertility/fecundity1.12392629
70MP0000013_abnormal_adipose_tissue1.12005545
71MP0001501_abnormal_sleep_pattern1.10063731
72MP0002653_abnormal_ependyma_morphology1.07494408
73MP0008569_lethality_at_weaning1.06921160
74MP0000681_abnormal_thyroid_gland1.06736670
75MP0002796_impaired_skin_barrier1.05686284
76MP0010030_abnormal_orbit_morphology1.05389943
77MP0001348_abnormal_lacrimal_gland1.04213427
78MP0003705_abnormal_hypodermis_morpholog1.03937290
79MP0002638_abnormal_pupillary_reflex1.03113995
80MP0000750_abnormal_muscle_regeneration1.02949464
81MP0004085_abnormal_heartbeat1.02623193
82MP0005451_abnormal_body_composition1.02006091
83MP0009250_abnormal_appendicular_skeleto1.01684298
84MP0005076_abnormal_cell_differentiation1.01409048
85MP0002089_abnormal_postnatal_growth/wei0.99265320
86MP0004043_abnormal_pH_regulation0.97918864
87MP0000733_abnormal_muscle_development0.96788927
88MP0005375_adipose_tissue_phenotype0.96370273
89MP0002736_abnormal_nociception_after0.96357477
90MP0004133_heterotaxia0.94820231
91MP0002752_abnormal_somatic_nervous0.94802864
92MP0001177_atelectasis0.94424176
93MP0004185_abnormal_adipocyte_glucose0.93712821
94MP0005248_abnormal_Harderian_gland0.93406587
95MP0000537_abnormal_urethra_morphology0.89241552
96MP0010386_abnormal_urinary_bladder0.89218312
97MP0000579_abnormal_nail_morphology0.89100718
98MP0001944_abnormal_pancreas_morphology0.89070251
99MP0002210_abnormal_sex_determination0.89003513
100MP0003693_abnormal_embryo_hatching0.88975380
101MP0005367_renal/urinary_system_phenotyp0.88679914
102MP0000516_abnormal_urinary_system0.88679914
103MP0003935_abnormal_craniofacial_develop0.88282741
104MP0002837_dystrophic_cardiac_calcinosis0.87382339
105MP0001661_extended_life_span0.85563302
106MP0003755_abnormal_palate_morphology0.85152568
107MP0006072_abnormal_retinal_apoptosis0.85001632
108MP0003634_abnormal_glial_cell0.84993547
109MP0001485_abnormal_pinna_reflex0.84368548
110MP0002697_abnormal_eye_size0.83907739
111MP0001905_abnormal_dopamine_level0.83875239
112MP0003122_maternal_imprinting0.83042434
113MP0002896_abnormal_bone_mineralization0.82912008
114MP0002069_abnormal_eating/drinking_beha0.82789699
115MP0001188_hyperpigmentation0.82214558
116MP0002098_abnormal_vibrissa_morphology0.81939472
117MP0000462_abnormal_digestive_system0.81158160
118MP0001502_abnormal_circadian_rhythm0.80384752
119MP0002233_abnormal_nose_morphology0.80261666
120MP0000049_abnormal_middle_ear0.79886945
121MP0000470_abnormal_stomach_morphology0.78683523
122MP0002751_abnormal_autonomic_nervous0.78391392
123MP0000003_abnormal_adipose_tissue0.77640190
124MP0002081_perinatal_lethality0.77497768
125MP0004233_abnormal_muscle_weight0.77248668
126MP0003115_abnormal_respiratory_system0.76975731
127MP0003942_abnormal_urinary_system0.76794530
128MP0003938_abnormal_ear_development0.76760788
129MP0002160_abnormal_reproductive_system0.76422947
130MP0000759_abnormal_skeletal_muscle0.75054996
131MP0000026_abnormal_inner_ear0.74853233
132MP0010234_abnormal_vibrissa_follicle0.74532002
133MP0003633_abnormal_nervous_system0.74084445
134MP0003385_abnormal_body_wall0.73974572
135MP0008961_abnormal_basal_metabolism0.72722521
136MP0001299_abnormal_eye_distance/0.72635354
137MP0001963_abnormal_hearing_physiology0.71501463
138MP0000747_muscle_weakness0.71252605
139MP0002229_neurodegeneration0.70125754
140MP0002116_abnormal_craniofacial_bone0.69907873
141MP0006292_abnormal_olfactory_placode0.68353291
142MP0008995_early_reproductive_senescence0.68058258
143MP0003631_nervous_system_phenotype0.67907416
144MP0004742_abnormal_vestibular_system0.66355803

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.16059827
2Visual hallucinations (HP:0002367)3.85316920
3Focal motor seizures (HP:0011153)3.68937225
4Double outlet right ventricle (HP:0001719)3.68211205
5Congenital malformation of the right heart (HP:0011723)3.68211205
6Bell-shaped thorax (HP:0001591)3.63861029
7Focal seizures (HP:0007359)3.56188940
8Hyperthyroidism (HP:0000836)3.43810860
9Bony spicule pigmentary retinopathy (HP:0007737)3.38612934
10Unilateral renal agenesis (HP:0000122)3.34077344
11Abnormality of the lower motor neuron (HP:0002366)3.28945214
12Ankle clonus (HP:0011448)3.11934592
13Abnormality of the parathyroid morphology (HP:0011766)2.93450271
14Epileptic encephalopathy (HP:0200134)2.85905534
15Obstructive sleep apnea (HP:0002870)2.82773907
16Limb dystonia (HP:0002451)2.82026362
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76975219
18Megalencephaly (HP:0001355)2.76077518
19Supranuclear gaze palsy (HP:0000605)2.73397275
20Insomnia (HP:0100785)2.72718090
21Severe visual impairment (HP:0001141)2.67588201
22Asymmetric septal hypertrophy (HP:0001670)2.67192989
23Atonic seizures (HP:0010819)2.66389688
24Aplasia of the musculature (HP:0100854)2.65863048
25Generalized tonic-clonic seizures (HP:0002069)2.63707256
26Torticollis (HP:0000473)2.62563009
27Absence seizures (HP:0002121)2.62145328
28Amblyopia (HP:0000646)2.62102750
29Drooling (HP:0002307)2.60956702
30Excessive salivation (HP:0003781)2.60956702
31Hepatoblastoma (HP:0002884)2.56764088
32Sudden death (HP:0001699)2.45855156
33Fetal akinesia sequence (HP:0001989)2.44002201
34Febrile seizures (HP:0002373)2.37809491
35Impulsivity (HP:0100710)2.37685211
36Distal lower limb muscle weakness (HP:0009053)2.37063280
37Muscle fiber atrophy (HP:0100295)2.32697932
38Broad-based gait (HP:0002136)2.31545427
39Hypoparathyroidism (HP:0000829)2.30500895
40Hyperventilation (HP:0002883)2.28725132
41Concave nail (HP:0001598)2.27863688
42Truncal obesity (HP:0001956)2.27687470
43Focal dystonia (HP:0004373)2.27147195
44Depression (HP:0000716)2.26665948
45Dialeptic seizures (HP:0011146)2.26504233
46Epileptiform EEG discharges (HP:0011182)2.26485903
47Popliteal pterygium (HP:0009756)2.25599761
48Progressive cerebellar ataxia (HP:0002073)2.25201262
49Cerebral inclusion bodies (HP:0100314)2.24762670
50Ventricular fibrillation (HP:0001663)2.24209736
51Renal dysplasia (HP:0000110)2.23104431
52Difficulty running (HP:0009046)2.21311916
53Akinesia (HP:0002304)2.21083672
54Resting tremor (HP:0002322)2.21058576
55Obsessive-compulsive behavior (HP:0000722)2.19742728
56Genetic anticipation (HP:0003743)2.16740690
57Poor eye contact (HP:0000817)2.16172489
58Hypoplastic ischia (HP:0003175)2.15760141
59EEG with generalized epileptiform discharges (HP:0011198)2.15687773
60Hyperkalemia (HP:0002153)2.15593865
61Abnormal ventriculo-arterial connection (HP:0011563)2.13256974
62Transposition of the great arteries (HP:0001669)2.13256974
63Abnormal connection of the cardiac segments (HP:0011545)2.13256974
64Mutism (HP:0002300)2.12468996
65Syncope (HP:0001279)2.12227720
66Insulin-resistant diabetes mellitus (HP:0000831)2.11216130
67Prolonged QT interval (HP:0001657)2.10903975
68Amyotrophic lateral sclerosis (HP:0007354)2.09710353
69Down-sloping shoulders (HP:0200021)2.09195544
70Hypsarrhythmia (HP:0002521)2.09103579
71Fatigable weakness (HP:0003473)2.08653957
72Abnormality of the neuromuscular junction (HP:0003398)2.08653957
73Neoplasm of the adrenal cortex (HP:0100641)2.07911900
74Abnormality of the corticospinal tract (HP:0002492)2.06666825
75Mildly elevated creatine phosphokinase (HP:0008180)2.06516690
76Pointed chin (HP:0000307)2.04605477
77Craniofacial dystonia (HP:0012179)2.04494006
78Urinary bladder sphincter dysfunction (HP:0002839)2.04321375
79Retinal dysplasia (HP:0007973)2.04221596
80Increased variability in muscle fiber diameter (HP:0003557)2.02142885
81Type 1 muscle fiber predominance (HP:0003803)2.02066521
82Periauricular skin pits (HP:0100277)2.01673016
83Preauricular pit (HP:0004467)2.01673016
84Attenuation of retinal blood vessels (HP:0007843)2.00477963
85Hypoplasia of the brainstem (HP:0002365)1.99557371
86Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99557371
87Bowel incontinence (HP:0002607)1.99468424
88Turricephaly (HP:0000262)1.98923442
89Hemiparesis (HP:0001269)1.98839618
90High anterior hairline (HP:0009890)1.98439186
91Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.98060297
92Exercise-induced myalgia (HP:0003738)1.98000139
93Thin bony cortex (HP:0002753)1.97381450
94Septate vagina (HP:0001153)1.96696121
95Overriding aorta (HP:0002623)1.96388083
96Amelogenesis imperfecta (HP:0000705)1.95875675
97Male infertility (HP:0003251)1.94310299
98Abnormal social behavior (HP:0012433)1.93743993
99Impaired social interactions (HP:0000735)1.93743993
100Impaired vibration sensation in the lower limbs (HP:0002166)1.93223834
101Ankyloglossia (HP:0010296)1.92065927
102Abnormality of the ischium (HP:0003174)1.91934720
103Hyperacusis (HP:0010780)1.91746861
104Bundle branch block (HP:0011710)1.91324984
105Renovascular hypertension (HP:0100817)1.90690580
106Rapidly progressive (HP:0003678)1.90339144
107Truncus arteriosus (HP:0001660)1.89208924
108Urinary urgency (HP:0000012)1.88943291
109Papilledema (HP:0001085)1.88286053
110Ventricular tachycardia (HP:0004756)1.88099229
111Insidious onset (HP:0003587)1.87647414
112Termporal pattern (HP:0011008)1.87647414
113Elfin facies (HP:0004428)1.87237721
114Absent epiphyses (HP:0010577)1.86237076
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86237076
116Anxiety (HP:0000739)1.86023601
117Progressive sensorineural hearing impairment (HP:0000408)1.85376112
118Type 2 muscle fiber atrophy (HP:0003554)1.85074498
119Lower limb amyotrophy (HP:0007210)1.84972919
120Thin ribs (HP:0000883)1.84845550
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82912100
122Hypercortisolism (HP:0001578)1.81791212
123Hypoventilation (HP:0002791)1.80756050
124Short palpebral fissure (HP:0012745)1.80578885
125Hypoplastic heart (HP:0001961)1.80123461
126Pterygium (HP:0001059)1.79739661
127Apathy (HP:0000741)1.79501302
128Cone-rod dystrophy (HP:0000548)1.79033486
129Stereotypic behavior (HP:0000733)1.78604397
130Abnormal large intestine physiology (HP:0012700)1.77719761
131Inappropriate behavior (HP:0000719)1.77693213
132Patellar dislocation (HP:0002999)1.77640042
133Menstrual irregularities (HP:0000858)1.74873057
134Agitation (HP:0000713)1.74302983
135Abnormal EKG (HP:0003115)1.73859476
136Abnormality of salivation (HP:0100755)1.73801649
137Atelectasis (HP:0100750)1.72504694
138Precocious puberty (HP:0000826)1.71702946
139Athetosis (HP:0002305)1.71364005
140Exotropia (HP:0000577)1.70324244
141Bronchomalacia (HP:0002780)1.70114853
142Easy fatigability (HP:0003388)1.70063863
143Action tremor (HP:0002345)1.69183620
144Lower limb muscle weakness (HP:0007340)1.69170295
145Asymmetry of the thorax (HP:0001555)1.68987777
146Germ cell neoplasia (HP:0100728)1.68687727
147Widely patent fontanelles and sutures (HP:0004492)1.68531872
148Distal arthrogryposis (HP:0005684)1.68478580
149Myopathic facies (HP:0002058)1.68149723
150Neoplasm of the heart (HP:0100544)1.68105490
151Blue irides (HP:0000635)1.67142879
152Abnormality of the aortic arch (HP:0012303)1.66901901
153Shallow orbits (HP:0000586)1.66750177
154Spina bifida occulta (HP:0003298)1.66195857
155Anosmia (HP:0000458)1.65765551
156Renal duplication (HP:0000075)1.65276754
157Spastic gait (HP:0002064)1.64766960
158Abnormality of skeletal muscle fiber size (HP:0012084)1.64508285
159Dysmetria (HP:0001310)1.64111167
160Hyperparathyroidism (HP:0000843)1.63886040
161Mesangial abnormality (HP:0001966)1.63505275
162Shawl scrotum (HP:0000049)1.63385714
163Neurofibrillary tangles (HP:0002185)1.63262637
164Bradycardia (HP:0001662)1.63222145
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.62911473
166Exostoses (HP:0100777)1.62625897
167Macroorchidism (HP:0000053)1.62079568
168Flat cornea (HP:0007720)1.62033220
169Truncal ataxia (HP:0002078)1.62012050
170Decreased circulating renin level (HP:0003351)1.61987513
171Aplasia/Hypoplasia of the earlobes (HP:0009906)1.60997491
172Skin pits (HP:0100276)1.60263258
173Heterotopia (HP:0002282)1.60209833
174Abnormality of cochlea (HP:0000375)1.58070433
175Malignant hyperthermia (HP:0002047)1.57696847
176Diminished movement (HP:0002374)1.55424739
177Infertility (HP:0000789)1.55074180
178Ulnar bowing (HP:0003031)1.54988806
179Abnormal respiratory epithelium morphology (HP:0012253)1.54443809
180Abnormal respiratory motile cilium morphology (HP:0005938)1.54443809
181Broad face (HP:0000283)1.53880469
182Aplasia/Hypoplasia involving the musculature (HP:0001460)1.53561522
183Flattened epiphyses (HP:0003071)1.52142292
184Tubulointerstitial nephritis (HP:0001970)1.50593385
185Partial agenesis of the corpus callosum (HP:0001338)1.49483992
186Patellar aplasia (HP:0006443)1.48924426
187Vesicoureteral reflux (HP:0000076)1.47299679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.91172302
2EPHA43.95650401
3TESK13.47914136
4MUSK3.17535825
5NTRK33.14178070
6PLK43.04016668
7MAP3K92.98781369
8SMG12.90036355
9EEF2K2.38384020
10SIK12.34066196
11EPHA22.22987599
12ICK2.21947348
13PRKD32.18485813
14MINK12.18297840
15MAP3K42.10260321
16DAPK22.02884551
17LATS22.02749151
18NTRK21.99283908
19PHKG21.95832709
20PHKG11.95832709
21TYRO31.90258471
22PAK61.85558822
23INSRR1.80790424
24KSR21.72718498
25MARK21.70624808
26PKN21.70558912
27RPS6KB21.57082422
28ERBB31.54934486
29MAP2K71.53575352
30KSR11.53375320
31ARAF1.47294193
32SIK21.44477994
33CDK51.40515597
34CDK71.39881776
35NTRK11.39385695
36MTOR1.34430803
37PLK21.33749887
38CAMKK11.28494562
39PRPF4B1.28364727
40MAP3K21.28049454
41TAOK11.24842996
42MAP2K21.23683423
43RIPK11.23039499
44DYRK21.22595355
45CAMK1G1.16210337
46MAPK131.15728022
47CDK121.15531807
48UHMK11.13347834
49WNK41.12429409
50MAP2K41.12250588
51CSNK1G21.09715955
52PDPK11.09103690
53PRKCG1.08961461
54GRK51.08316107
55DDR21.08035073
56LATS11.07232294
57BRD41.06403438
58PAK31.05635230
59DAPK11.05275822
60DYRK31.02321794
61STK38L1.01290961
62TNIK1.01257617
63MAPKAPK31.00029262
64IRAK30.99329293
65EPHB20.98930959
66DYRK1B0.94820510
67CAMK2B0.93555514
68DYRK1A0.93129136
69CAMK2A0.92673611
70VRK20.90404125
71NEK20.89048417
72TRIB30.86213757
73RPS6KC10.84493653
74RPS6KL10.84493653
75MAP3K60.84262996
76MAPKAPK50.84160330
77CDK150.84151660
78CDK140.83205248
79CAMK10.83155333
80NME20.82597208
81CDK180.82236654
82STK380.81686446
83AURKA0.80392194
84NME10.77971686
85CDK11A0.76366552
86PNCK0.75572911
87RPS6KA60.75055459
88CSNK1A1L0.73829950
89MST1R0.71158880
90BRSK10.71092698
91FER0.70857338
92STK110.70747087
93PINK10.70560032
94CAMK1D0.70248922
95FGR0.69860213
96PKN10.69536428
97AKT20.68854712
98MAP3K10.67884503
99ILK0.67696021
100RPS6KA10.67523272
101CDC42BPA0.67100029
102CSNK1G30.66536601
103MAP3K100.65805442
104MAP3K70.64941981
105RPS6KA20.64308208
106PDK10.62277225
107CAMK2D0.61580602
108RET0.61342997
109PTK2B0.61233437
110CASK0.61196911
111STK390.60969762
112ALK0.60190015
113RAF10.59157880
114MAPK80.57954702
115GSK3B0.56501508
116NEK60.55488857
117PRKCI0.54446647
118SGK30.53952001
119DMPK0.53555612
120PDGFRA0.53403347
121PTK20.52707589
122CDK10.52381387
123PRKCZ0.52350020
124PRKCH0.51184831
125PRKAA10.51065645
126CDK20.50694951
127SGK4940.49575068
128SGK2230.49575068
129PRKCE0.49447998
130SGK10.49354419
131CAMK40.49151686
132BRAF0.48917334
133TNK20.47064807
134MAPK110.46728891
135CHEK20.46573193
136CAMK2G0.45988095
137MAPK140.44827542
138CDK40.44278511
139HIPK20.42613840
140BMPR20.41705278
141RPS6KA30.41560218
142MAPK120.40708741
143MAP2K10.40284916
144MAPK90.39924792
145CSNK1G10.38695270
146CSNK1E0.38539065
147CHEK10.37842223
148MAPK150.37660457
149FYN0.37074804
150MAPK100.36171509
151LMTK20.36144204

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.49953216
2Sulfur relay system_Homo sapiens_hsa041222.79234413
3Circadian entrainment_Homo sapiens_hsa047132.70649907
4Nicotine addiction_Homo sapiens_hsa050332.52837902
5Long-term potentiation_Homo sapiens_hsa047202.39486406
6Glutamatergic synapse_Homo sapiens_hsa047242.38777410
7GABAergic synapse_Homo sapiens_hsa047272.29455036
8Synaptic vesicle cycle_Homo sapiens_hsa047212.24271748
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22078263
10Morphine addiction_Homo sapiens_hsa050322.22009795
11Amphetamine addiction_Homo sapiens_hsa050312.10882032
12Dopaminergic synapse_Homo sapiens_hsa047282.07929629
13Insulin secretion_Homo sapiens_hsa049112.07847136
14Cholinergic synapse_Homo sapiens_hsa047251.94321622
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93219024
16Notch signaling pathway_Homo sapiens_hsa043301.90142193
17Axon guidance_Homo sapiens_hsa043601.79735279
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79082218
19Salivary secretion_Homo sapiens_hsa049701.77801235
20Taste transduction_Homo sapiens_hsa047421.74599681
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73010669
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68410313
23Phenylalanine metabolism_Homo sapiens_hsa003601.68262701
24Oxytocin signaling pathway_Homo sapiens_hsa049211.67327008
25Gastric acid secretion_Homo sapiens_hsa049711.66912480
26Gap junction_Homo sapiens_hsa045401.58464272
27GnRH signaling pathway_Homo sapiens_hsa049121.58446694
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56034847
29Cocaine addiction_Homo sapiens_hsa050301.52132973
30Serotonergic synapse_Homo sapiens_hsa047261.51724167
31Renin secretion_Homo sapiens_hsa049241.48740221
32Dorso-ventral axis formation_Homo sapiens_hsa043201.40432047
33Estrogen signaling pathway_Homo sapiens_hsa049151.34705599
34cAMP signaling pathway_Homo sapiens_hsa040241.33748136
35Calcium signaling pathway_Homo sapiens_hsa040201.33601063
36Long-term depression_Homo sapiens_hsa047301.33433655
37Melanogenesis_Homo sapiens_hsa049161.32814768
38Glioma_Homo sapiens_hsa052141.32284755
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24487481
40Lysine degradation_Homo sapiens_hsa003101.24384805
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21554140
42Type II diabetes mellitus_Homo sapiens_hsa049301.19339741
43Endometrial cancer_Homo sapiens_hsa052131.18036830
44ErbB signaling pathway_Homo sapiens_hsa040121.16129880
45Dilated cardiomyopathy_Homo sapiens_hsa054141.14811095
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12244519
47Cardiac muscle contraction_Homo sapiens_hsa042601.11866941
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.07810802
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07748347
50Hedgehog signaling pathway_Homo sapiens_hsa043401.07658503
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04108675
52Inositol phosphate metabolism_Homo sapiens_hsa005621.02456309
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01698390
54Phototransduction_Homo sapiens_hsa047440.98381468
55Biosynthesis of amino acids_Homo sapiens_hsa012300.96813265
56Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.96698325
57Oocyte meiosis_Homo sapiens_hsa041140.95107461
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95005284
59Bladder cancer_Homo sapiens_hsa052190.93873041
60Arginine and proline metabolism_Homo sapiens_hsa003300.91959443
61Basal cell carcinoma_Homo sapiens_hsa052170.90843889
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89698007
63Wnt signaling pathway_Homo sapiens_hsa043100.88879064
64Alcoholism_Homo sapiens_hsa050340.85340634
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84824304
66Vibrio cholerae infection_Homo sapiens_hsa051100.83823624
67Folate biosynthesis_Homo sapiens_hsa007900.82521451
68Thyroid cancer_Homo sapiens_hsa052160.80884585
69Ras signaling pathway_Homo sapiens_hsa040140.80366680
70Hippo signaling pathway_Homo sapiens_hsa043900.78864898
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.78102521
72VEGF signaling pathway_Homo sapiens_hsa043700.77413179
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.77146053
74Ovarian steroidogenesis_Homo sapiens_hsa049130.76356863
75Collecting duct acid secretion_Homo sapiens_hsa049660.76188901
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.75551999
77Pentose phosphate pathway_Homo sapiens_hsa000300.75454912
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73244019
79Tight junction_Homo sapiens_hsa045300.72601561
80Colorectal cancer_Homo sapiens_hsa052100.71964417
81Pancreatic secretion_Homo sapiens_hsa049720.71466286
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.71226928
83Renal cell carcinoma_Homo sapiens_hsa052110.70349809
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68727869
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68615365
86Rap1 signaling pathway_Homo sapiens_hsa040150.68569437
87Thyroid hormone synthesis_Homo sapiens_hsa049180.68319236
88Choline metabolism in cancer_Homo sapiens_hsa052310.67371039
89Non-small cell lung cancer_Homo sapiens_hsa052230.66313798
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66013691
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66008756
92MAPK signaling pathway_Homo sapiens_hsa040100.65760147
93Fatty acid metabolism_Homo sapiens_hsa012120.65501401
94Insulin signaling pathway_Homo sapiens_hsa049100.63998051
95Fructose and mannose metabolism_Homo sapiens_hsa000510.63191473
962-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62478074
97Basal transcription factors_Homo sapiens_hsa030220.61659078
98Tyrosine metabolism_Homo sapiens_hsa003500.61048603
99mTOR signaling pathway_Homo sapiens_hsa041500.60012645
100Glucagon signaling pathway_Homo sapiens_hsa049220.59405981
101Sulfur metabolism_Homo sapiens_hsa009200.58145247
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.57329263
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56944836
104Prostate cancer_Homo sapiens_hsa052150.54316469
105Adherens junction_Homo sapiens_hsa045200.53667203
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52789866
107Alzheimers disease_Homo sapiens_hsa050100.52326569
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52219981
109Arginine biosynthesis_Homo sapiens_hsa002200.52045376
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51317521
111Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50435202
112Circadian rhythm_Homo sapiens_hsa047100.45205483
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44272286
114Maturity onset diabetes of the young_Homo sapiens_hsa049500.43932753
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.42879412
116Endocytosis_Homo sapiens_hsa041440.41534450
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41440094
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41266636
119Prion diseases_Homo sapiens_hsa050200.40604217
120Focal adhesion_Homo sapiens_hsa045100.39855177
121Prolactin signaling pathway_Homo sapiens_hsa049170.39719749
122Fatty acid biosynthesis_Homo sapiens_hsa000610.38729542
123AMPK signaling pathway_Homo sapiens_hsa041520.33086408
124Melanoma_Homo sapiens_hsa052180.31970543
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31632786

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