FOXO4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.04950646
2negative regulation of cell killing (GO:0031342)5.04950646
3negative regulation of erythrocyte differentiation (GO:0045647)4.87205978
4positive regulation of gamma-delta T cell activation (GO:0046645)4.62070263
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.32746631
6positive regulation by symbiont of host defense response (GO:0052509)4.28465534
7modulation by symbiont of host defense response (GO:0052031)4.28465534
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.28465534
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.28465534
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.28465534
11modulation by symbiont of host immune response (GO:0052553)4.28465534
12negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.07670920
13lysine metabolic process (GO:0006553)4.06280280
14lysine catabolic process (GO:0006554)4.06280280
15detection of other organism (GO:0098543)3.89161979
16detection of molecule of bacterial origin (GO:0032490)3.88853126
17carnitine shuttle (GO:0006853)3.88667621
18plasma membrane repair (GO:0001778)3.86469319
19fatty acid transmembrane transport (GO:1902001)3.71113197
20muscle filament sliding (GO:0030049)3.70341906
21actin-myosin filament sliding (GO:0033275)3.70341906
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.68299500
23regulation of hippo signaling (GO:0035330)3.67917082
24negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.67145470
25detection of bacterium (GO:0016045)3.62307212
26neutrophil activation involved in immune response (GO:0002283)3.62142554
27detection of external biotic stimulus (GO:0098581)3.61539992
28sulfur amino acid catabolic process (GO:0000098)3.59960002
29regulation of gamma-delta T cell activation (GO:0046643)3.58541144
30macrophage activation involved in immune response (GO:0002281)3.57917043
31oxygen transport (GO:0015671)3.56799779
322-oxoglutarate metabolic process (GO:0006103)3.56385274
33regulation of posttranscriptional gene silencing (GO:0060147)3.51948720
34regulation of gene silencing by miRNA (GO:0060964)3.51948720
35regulation of gene silencing by RNA (GO:0060966)3.51948720
36maternal placenta development (GO:0001893)3.50050657
37antigen processing and presentation of endogenous antigen (GO:0019883)3.49872407
38regulation of gamma-delta T cell differentiation (GO:0045586)3.48159932
39bundle of His cell to Purkinje myocyte communication (GO:0086069)3.45694439
40cellular response to epinephrine stimulus (GO:0071872)3.39447844
41regulation of B cell receptor signaling pathway (GO:0050855)3.38856038
42sarcomere organization (GO:0045214)3.37626639
43cellular extravasation (GO:0045123)3.29046390
44positive regulation of fatty acid beta-oxidation (GO:0032000)3.26531624
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.23764666
46gas transport (GO:0015669)3.23679172
47regulation of cholesterol homeostasis (GO:2000188)3.23395768
48regulation of skeletal muscle contraction (GO:0014819)3.23229320
49valine metabolic process (GO:0006573)3.21655559
50response to peptidoglycan (GO:0032494)3.21649249
51pre-miRNA processing (GO:0031054)3.21141903
524-hydroxyproline metabolic process (GO:0019471)3.19944874
53regulation of fatty acid beta-oxidation (GO:0031998)3.16192691
54positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14520170
55detection of biotic stimulus (GO:0009595)3.13441977
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.12776550
57positive regulation of Rap GTPase activity (GO:0032854)3.10678440
58trophectodermal cell differentiation (GO:0001829)3.09157213
59negative regulation of cell size (GO:0045792)3.08362601
60aspartate family amino acid catabolic process (GO:0009068)3.07856469
61phospholipid homeostasis (GO:0055091)3.07677244
62positive regulation of cellular amide metabolic process (GO:0034250)3.07671268
63positive thymic T cell selection (GO:0045059)3.04862297
64skeletal muscle adaptation (GO:0043501)3.04600165
65alpha-linolenic acid metabolic process (GO:0036109)3.03801071
66regulation of interferon-beta biosynthetic process (GO:0045357)3.02467733
67triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.02357892
68regulation of ARF protein signal transduction (GO:0032012)3.02130833
69regulation of necroptotic process (GO:0060544)3.01251097
70carnitine transmembrane transport (GO:1902603)3.00375010
71low-density lipoprotein particle clearance (GO:0034383)3.00328519
72actin-mediated cell contraction (GO:0070252)2.98815017
73positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96414510
74positive regulation of histone deacetylation (GO:0031065)2.95819131
75amino-acid betaine transport (GO:0015838)2.95525698
76carnitine transport (GO:0015879)2.95525698
77biotin metabolic process (GO:0006768)2.95371859
78negative regulation of potassium ion transmembrane transport (GO:1901380)2.95008770
79regulation of fatty acid oxidation (GO:0046320)2.94249884
803-UTR-mediated mRNA stabilization (GO:0070935)2.93858322
81adherens junction assembly (GO:0034333)2.91150739
82response to interleukin-15 (GO:0070672)2.90932077
83myofibril assembly (GO:0030239)2.89994460
84positive regulation of fatty acid oxidation (GO:0046321)2.89646004
85cellular modified amino acid catabolic process (GO:0042219)2.88490819
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88031278
87microglial cell activation (GO:0001774)2.87232575
88negative regulation of leukocyte mediated immunity (GO:0002704)2.87000392
89regulation of T-helper 2 cell differentiation (GO:0045628)2.86877693
90cell-substrate adherens junction assembly (GO:0007045)2.86742994
91focal adhesion assembly (GO:0048041)2.86742994
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.86454053
93polarized epithelial cell differentiation (GO:0030859)2.86323804
94kynurenine metabolic process (GO:0070189)2.86020766
95regulation of mast cell degranulation (GO:0043304)2.85301998
96cardiac myofibril assembly (GO:0055003)2.84671289
97heterochromatin organization (GO:0070828)2.84333603
98leukocyte aggregation (GO:0070486)2.84323046
99germinal center formation (GO:0002467)2.83955888
100regulation of leukocyte degranulation (GO:0043300)2.83778464
101fatty acid beta-oxidation (GO:0006635)2.83622852
102regulation of platelet aggregation (GO:0090330)2.83605893
103macrophage activation (GO:0042116)2.83281119
104paraxial mesoderm development (GO:0048339)2.82697506
105regulation of sequestering of triglyceride (GO:0010889)2.82676706
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.82528535
107response to host immune response (GO:0052572)2.82528535
108B cell receptor signaling pathway (GO:0050853)2.81422395
109positive regulation of SMAD protein import into nucleus (GO:0060391)2.80007937
110response to muramyl dipeptide (GO:0032495)2.79811926
111cell-substrate junction assembly (GO:0007044)2.79074821
112negative regulation of necroptotic process (GO:0060546)2.77260591
113acetyl-CoA metabolic process (GO:0006084)2.75520576
114glyoxylate metabolic process (GO:0046487)2.74579086
115neutrophil activation (GO:0042119)2.73153539
116plasma lipoprotein particle clearance (GO:0034381)2.72927676
117L-phenylalanine metabolic process (GO:0006558)2.72861312
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.72861312
119response to epinephrine (GO:0071871)2.72596322
120negative regulation of toll-like receptor signaling pathway (GO:0034122)2.71952526
121leukocyte migration involved in inflammatory response (GO:0002523)2.71484194
122high-density lipoprotein particle remodeling (GO:0034375)2.71406258
123negative regulation of interleukin-12 production (GO:0032695)2.69404433
124tricarboxylic acid metabolic process (GO:0072350)2.69052412
125response to host (GO:0075136)2.68959877
126response to host defenses (GO:0052200)2.68959877
127response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68959877
128positive regulation of receptor recycling (GO:0001921)2.68504673
129epithelial cell-cell adhesion (GO:0090136)2.67608901
130gap junction assembly (GO:0016264)2.66876367
131regulation of triglyceride catabolic process (GO:0010896)2.66622947
132negative regulation of fibrinolysis (GO:0051918)2.66082618
133dicarboxylic acid biosynthetic process (GO:0043650)2.65933537
134negative regulation of T cell mediated immunity (GO:0002710)2.65923296
135serine family amino acid catabolic process (GO:0009071)2.65812534
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.65095777
137respiratory burst (GO:0045730)2.63262884
138actin filament-based movement (GO:0030048)2.62721478
139regulation of cholesterol storage (GO:0010885)2.62566689
140regulation of protein activation cascade (GO:2000257)2.60464245
141fatty acid oxidation (GO:0019395)2.60078693
142cysteine metabolic process (GO:0006534)2.58697065
143amino-acid betaine metabolic process (GO:0006577)2.58163258
144regulation of macrophage cytokine production (GO:0010935)2.57465445
145production of molecular mediator involved in inflammatory response (GO:0002532)2.56926376
146protein-lipid complex assembly (GO:0065005)2.56613536
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56479052
148L-phenylalanine catabolic process (GO:0006559)2.56479052
149regulation of regulated secretory pathway (GO:1903305)2.56303339
150erythrocyte development (GO:0048821)2.55978425
151hippo signaling (GO:0035329)2.55018425
152tricarboxylic acid cycle (GO:0006099)2.54072778
153granulocyte activation (GO:0036230)2.54057064
154progesterone metabolic process (GO:0042448)2.53702424
155skeletal muscle contraction (GO:0003009)2.53689039
156negative regulation of protein activation cascade (GO:2000258)2.52982610
157lipid oxidation (GO:0034440)2.52896798
158creatine metabolic process (GO:0006600)2.52062590
159regulation of complement activation (GO:0030449)2.52017028
160regulation of Rap GTPase activity (GO:0032317)2.51931294
161glycine metabolic process (GO:0006544)2.51501353
162ethanol oxidation (GO:0006069)2.51435088
163regulation of amyloid precursor protein catabolic process (GO:1902991)2.50422637
164quaternary ammonium group transport (GO:0015697)2.49931554
165regulation of mast cell activation involved in immune response (GO:0033006)2.49896906
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.49834208
167homocysteine metabolic process (GO:0050667)2.49657926
168establishment of apical/basal cell polarity (GO:0035089)2.49253358
169basement membrane organization (GO:0071711)2.48642238
170cellular response to osmotic stress (GO:0071470)2.48503482
171regulation of necrotic cell death (GO:0010939)2.48479641
172positive T cell selection (GO:0043368)2.48177968
173myeloid cell activation involved in immune response (GO:0002275)2.48101967
174regulation of SMAD protein import into nucleus (GO:0060390)2.47806124
175negative regulation of heart growth (GO:0061117)2.47778621
176negative regulation of cardiac muscle tissue growth (GO:0055022)2.47778621
177negative regulation of type 2 immune response (GO:0002829)2.47534859
178mannose metabolic process (GO:0006013)2.47520666
179positive regulation of triglyceride metabolic process (GO:0090208)2.47337287
180purine nucleotide salvage (GO:0032261)2.46768884
181positive regulation of macrophage cytokine production (GO:0060907)2.46763185
182positive regulation of myotube differentiation (GO:0010831)2.46555360
183actomyosin structure organization (GO:0031032)2.44719381
184negative regulation of necrotic cell death (GO:0060547)2.44068468
185sarcoplasmic reticulum calcium ion transport (GO:0070296)2.43322891
186negative regulation of myotube differentiation (GO:0010832)2.40770133
187lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40553130
188positive regulation of Cdc42 GTPase activity (GO:0043089)2.40430516
189hemoglobin metabolic process (GO:0020027)2.40215728
190thymic T cell selection (GO:0045061)2.39590851
191negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.38877234
192actin filament polymerization (GO:0030041)2.38088049
193regulation of cellular amide metabolic process (GO:0034248)2.35350065
194JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.34386987
195positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.33731804
196antigen processing and presentation via MHC class Ib (GO:0002475)2.33214667

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.51058611
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.98674068
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.40507911
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.26966661
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.22102986
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75991698
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.64173828
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.42782370
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.41819217
10CLOCK_20551151_ChIP-Seq_293T_Human2.37740685
11ZNF263_19887448_ChIP-Seq_K562_Human2.31443139
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.25863471
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24444758
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20454690
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.17298373
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14598603
17MYC_22102868_ChIP-Seq_BL_Human2.13733739
18VDR_24763502_ChIP-Seq_THP-1_Human2.12326676
19SCL_19346495_ChIP-Seq_HPC-7_Human2.10509174
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.09975382
21GATA1_19941827_ChIP-Seq_MEL_Mouse2.02830631
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.01784881
23KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00440188
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00440188
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00440188
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00287206
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99047398
28SPI1_23127762_ChIP-Seq_K562_Human1.98863147
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.91116332
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.90864300
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.89275942
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86086110
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.84665350
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84392638
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.84346737
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.84261090
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83343482
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81682371
39GATA1_22025678_ChIP-Seq_K562_Human1.81524193
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81040645
41RACK7_27058665_Chip-Seq_MCF-7_Human1.79272470
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77793553
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.77742502
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.76647035
45FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.75914727
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75762266
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75095746
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.74104653
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72228190
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70724245
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70304264
52STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70172507
53RUNX_20019798_ChIP-Seq_JUKART_Human1.69750063
54TCF7_22412390_ChIP-Seq_EML_Mouse1.69669741
55KDM2B_26808549_Chip-Seq_DND41_Human1.68795424
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.68291064
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66940455
58ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64276749
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63583823
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61935810
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55009662
62LXR_22292898_ChIP-Seq_THP-1_Human1.54838689
63TCF3_18692474_ChIP-Seq_MEFs_Mouse1.54606126
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.53827984
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52694916
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49998489
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.49541145
68GATA2_19941826_ChIP-Seq_K562_Human1.48460820
69ATF3_27146783_Chip-Seq_COLON_Human1.48275946
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.46887497
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46301988
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.43385733
73EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43245851
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.43213445
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42479706
76MAF_26560356_Chip-Seq_TH2_Human1.42371120
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41697298
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39353874
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.39315498
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.38552844
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38201609
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38129511
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.37609168
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.37124714
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36833726
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.36254332
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36057831
88VDR_21846776_ChIP-Seq_THP-1_Human1.35215079
89E2F7_22180533_ChIP-Seq_HELA_Human1.33298320
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.31677612
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.31677612
92NCOR1_26117541_ChIP-Seq_K562_Human1.31485643
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.30486454
94SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29295710
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29210824
96GATA6_25053715_ChIP-Seq_YYC3_Human1.28973358
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28106301
98IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27818146
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26079576
100SPI1_23547873_ChIP-Seq_NB4_Human1.25594614
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24750672
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24407691
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23267546
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23000190
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.22704807
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22095590
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21229348
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20608669
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20586068
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20351874
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.20048305
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.19921279
113KDM2B_26808549_Chip-Seq_K562_Human1.17434814
114CREB1_26743006_Chip-Seq_LNCaP_Human1.16438838
115GATA1_19941826_ChIP-Seq_K562_Human1.15199333
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14726711
117MYB_26560356_Chip-Seq_TH2_Human1.13752721
118SMC4_20622854_ChIP-Seq_HELA_Human1.13124928
119PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12412438
120MYB_26560356_Chip-Seq_TH1_Human1.12062493
121SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12025700
122CDX2_20551321_ChIP-Seq_CACO-2_Human1.11294650
123PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10578082
124DROSHA_22980978_ChIP-Seq_HELA_Human1.08604201
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08295072
126MAF_26560356_Chip-Seq_TH1_Human1.07799111
127SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07315216
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06559751
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05307679
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04571153
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04347126
132PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03510460
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.03143118
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03117149
135FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03027145
136CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02968482
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02967075
138PU_27001747_Chip-Seq_BMDM_Mouse1.02519299
139OCT4_18692474_ChIP-Seq_MEFs_Mouse1.02514798
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01980069
141CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01816035
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01241763
143KDM2B_26808549_Chip-Seq_JURKAT_Human1.01149913
144RARB_27405468_Chip-Seq_BRAIN_Mouse1.00983671
145BCOR_27268052_Chip-Seq_Bcells_Human1.00931156
146TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00451879
147P68_20966046_ChIP-Seq_HELA_Human0.99546574
148KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99222360
149GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.97698857
150POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97519927
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.95437245
152SALL4_18804426_ChIP-ChIP_XEN_Mouse0.94560656
153TP53_22127205_ChIP-Seq_IMR90_Human0.94231846
154NANOG_21062744_ChIP-ChIP_HESCs_Human0.93224353
155UTX_26944678_Chip-Seq_JUKART_Human0.93096614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.98998931
2MP0003303_peritoneal_inflammation3.55154529
3MP0003724_increased_susceptibility_to3.47137482
4MP0005451_abnormal_body_composition3.41706570
5MP0003436_decreased_susceptibility_to3.11958626
6MP0008260_abnormal_autophagy2.97243166
7MP0005360_urolithiasis2.77344434
8MP0004264_abnormal_extraembryonic_tissu2.74566798
9MP0002139_abnormal_hepatobiliary_system2.61451113
10MP0004185_abnormal_adipocyte_glucose2.29359338
11MP0000749_muscle_degeneration2.27389086
12MP0002419_abnormal_innate_immunity2.18059445
13MP0005085_abnormal_gallbladder_physiolo2.16519758
14MP0002837_dystrophic_cardiac_calcinosis2.15715627
15MP0005365_abnormal_bile_salt2.11919814
16MP0003806_abnormal_nucleotide_metabolis2.10717607
17MP0004130_abnormal_muscle_cell2.06829889
18MP0003690_abnormal_glial_cell2.06666381
19MP0000751_myopathy2.05157841
20MP0004087_abnormal_muscle_fiber2.04423279
21MP0003646_muscle_fatigue2.02143779
22MP0004084_abnormal_cardiac_muscle2.00892988
23MP0003828_pulmonary_edema1.99122197
24MP0002269_muscular_atrophy1.97936197
25MP0003172_abnormal_lysosome_physiology1.96749784
26MP0005025_abnormal_response_to1.93941598
27MP0009278_abnormal_bone_marrow1.93077265
28MP0001835_abnormal_antigen_presentation1.89887333
29MP0000750_abnormal_muscle_regeneration1.89350579
30MP0003566_abnormal_cell_adhesion1.89112039
31MP0005464_abnormal_platelet_physiology1.88765791
32MP0009840_abnormal_foam_cell1.85300065
33MP0005666_abnormal_adipose_tissue1.83751082
34MP0004036_abnormal_muscle_relaxation1.81010744
35MP0000685_abnormal_immune_system1.78210521
36MP0004145_abnormal_muscle_electrophysio1.77557088
37MP0004510_myositis1.76773700
38MP0005000_abnormal_immune_tolerance1.74957367
39MP0010329_abnormal_lipoprotein_level1.72449946
40MP0004272_abnormal_basement_membrane1.72445875
41MP0005083_abnormal_biliary_tract1.72275982
42MP0001790_abnormal_immune_system1.70778523
43MP0005387_immune_system_phenotype1.70778523
44MP0000747_muscle_weakness1.69460786
45MP0005670_abnormal_white_adipose1.67892838
46MP0001800_abnormal_humoral_immune1.66750254
47MP0004947_skin_inflammation1.65912101
48MP0001849_ear_inflammation1.65204167
49MP0003763_abnormal_thymus_physiology1.64449360
50MP0003252_abnormal_bile_duct1.64345351
51MP0010352_gastrointestinal_tract_polyps1.64140804
52MP0003329_amyloid_beta_deposits1.63289285
53MP0005058_abnormal_lysosome_morphology1.62918274
54MP0002106_abnormal_muscle_physiology1.61535315
55MP0002420_abnormal_adaptive_immunity1.60578741
56MP0010630_abnormal_cardiac_muscle1.58785026
57MP0001819_abnormal_immune_cell1.58623105
58MP0000759_abnormal_skeletal_muscle1.56867100
59MP0000733_abnormal_muscle_development1.55182189
60MP0003123_paternal_imprinting1.53865586
61MP0001533_abnormal_skeleton_physiology1.53463837
62MP0002723_abnormal_immune_serum1.53282015
63MP0005076_abnormal_cell_differentiation1.50909185
64MP0005330_cardiomyopathy1.50206013
65MP0009785_altered_susceptibility_to1.44455526
66MP0003075_altered_response_to1.43782813
67MP0004197_abnormal_fetal_growth/weight/1.43173909
68MP0002452_abnormal_antigen_presenting1.41772570
69MP0002398_abnormal_bone_marrow1.38652799
70MP0010234_abnormal_vibrissa_follicle1.37922052
71MP0004233_abnormal_muscle_weight1.37854296
72MP0005397_hematopoietic_system_phenotyp1.37718478
73MP0001545_abnormal_hematopoietic_system1.37718478
74MP0006082_CNS_inflammation1.36182600
75MP0003122_maternal_imprinting1.35080798
76MP0003191_abnormal_cellular_cholesterol1.34748096
77MP0003567_abnormal_fetal_cardiomyocyte1.34330892
78MP0002396_abnormal_hematopoietic_system1.32080812
79MP0002332_abnormal_exercise_endurance1.32033612
80MP0005375_adipose_tissue_phenotype1.31798393
81MP0006054_spinal_hemorrhage1.30737127
82MP0002086_abnormal_extraembryonic_tissu1.30676019
83MP0002254_reproductive_system_inflammat1.30193674
84MP0002998_abnormal_bone_remodeling1.30133963
85MP0002088_abnormal_embryonic_growth/wei1.29076418
86MP0003984_embryonic_growth_retardation1.28974609
87MP0001851_eye_inflammation1.27633664
88MP0008775_abnormal_heart_ventricle1.27581946
89MP0002132_abnormal_respiratory_system1.25944955
90MP0005369_muscle_phenotype1.25848812
91MP0000609_abnormal_liver_physiology1.25654544
92MP0004381_abnormal_hair_follicle1.23340489
93MP0002405_respiratory_system_inflammati1.22509487
94MP0000716_abnormal_immune_system1.21707797
95MP0005620_abnormal_muscle_contractility1.21465510
96MP0008961_abnormal_basal_metabolism1.20469529
97MP0005380_embryogenesis_phenotype1.19765531
98MP0001672_abnormal_embryogenesis/_devel1.19765531
99MP0000604_amyloidosis1.19499545
100MP0003183_abnormal_peptide_metabolism1.17905377
101MP0005671_abnormal_response_to1.17457789
102MP0008875_abnormal_xenobiotic_pharmacok1.17098896
103MP0008438_abnormal_cutaneous_collagen1.15712331
104MP0002722_abnormal_immune_system1.14061944
105MP0010155_abnormal_intestine_physiology1.13527832
106MP0005166_decreased_susceptibility_to1.12410921
107MP0009333_abnormal_splenocyte_physiolog1.12192895
108MP0005319_abnormal_enzyme/_coenzyme1.10897100
109MP0005409_darkened_coat_color1.10128134
110MP0003879_abnormal_hair_cell1.10088287
111MP0000703_abnormal_thymus_morphology1.09767485
112MP0002796_impaired_skin_barrier1.08929268
113MP0002148_abnormal_hypersensitivity_rea1.06077033
114MP0004484_altered_response_of1.05848494
115MP0003866_abnormal_defecation1.05728438
116MP0000689_abnormal_spleen_morphology1.05680521
117MP0005385_cardiovascular_system_phenoty1.05432504
118MP0001544_abnormal_cardiovascular_syste1.05432504
119MP0005023_abnormal_wound_healing1.04601197
120MP0000858_altered_metastatic_potential1.03331727
121MP0002971_abnormal_brown_adipose1.02023787
122MP0002429_abnormal_blood_cell1.01983701
123MP0006036_abnormal_mitochondrial_physio1.00233967
124MP0003045_fibrosis0.99214059
125MP0009053_abnormal_anal_canal0.98578827
126MP0008874_decreased_physiological_sensi0.97694080
127MP0000465_gastrointestinal_hemorrhage0.97397707
128MP0003221_abnormal_cardiomyocyte_apopto0.97297799
129MP0001666_abnormal_nutrient_absorption0.96941813
130MP0001730_embryonic_growth_arrest0.96693678
131MP0004859_abnormal_synaptic_plasticity0.96298307
132MP0002877_abnormal_melanocyte_morpholog0.96097581
133MP0005266_abnormal_metabolism0.96082107
134MP0000266_abnormal_heart_morphology0.95939832
135MP0005332_abnormal_amino_acid0.95933817
136MP0001845_abnormal_inflammatory_respons0.95096363
137MP0000920_abnormal_myelination0.94498649
138MP0000003_abnormal_adipose_tissue0.93727956
139MP0004883_abnormal_blood_vessel0.92743116
140MP0003300_gastrointestinal_ulcer0.92356902
141MP0009672_abnormal_birth_weight0.92110650
142MP0005187_abnormal_penis_morphology0.91752574
143MP0002972_abnormal_cardiac_muscle0.91655531
144MP0006138_congestive_heart_failure0.89768543
145MP0002084_abnormal_developmental_patter0.89638710
146MP0008004_abnormal_stomach_pH0.89353932
147MP0003121_genomic_imprinting0.88461606
148MP0005275_abnormal_skin_tensile0.87707009
149MP0010368_abnormal_lymphatic_system0.87532164
150MP0002925_abnormal_cardiovascular_devel0.85827151
151MP0004858_abnormal_nervous_system0.85792423
152MP0010030_abnormal_orbit_morphology0.85695737
153MP0004147_increased_porphyrin_level0.85614234
154MP0003091_abnormal_cell_migration0.85233281
155MP0002118_abnormal_lipid_homeostasis0.84591371
156MP0008469_abnormal_protein_level0.83311113
157MP0000598_abnormal_liver_morphology0.82379150
158MP0001697_abnormal_embryo_size0.81585634
159MP0005623_abnormal_meninges_morphology0.81132545
160MP0002127_abnormal_cardiovascular_syste0.79817889
161MP0003453_abnormal_keratinocyte_physiol0.79131488
162MP0003656_abnormal_erythrocyte_physiolo0.78484239
163MP0009643_abnormal_urine_homeostasis0.77857497
164MP0002128_abnormal_blood_circulation0.77676408
165MP0004215_abnormal_myocardial_fiber0.75981180
166MP0000537_abnormal_urethra_morphology0.75874565
167MP0002653_abnormal_ependyma_morphology0.74528175
168MP0002085_abnormal_embryonic_tissue0.72359703
169MP0003119_abnormal_digestive_system0.70735691

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.40659550
2Eczematoid dermatitis (HP:0000976)4.96393161
3Increased connective tissue (HP:0009025)4.42934206
4Exercise-induced myalgia (HP:0003738)4.38102570
5Difficulty running (HP:0009046)4.20519309
6Myoglobinuria (HP:0002913)4.07027758
7Hyporeflexia of lower limbs (HP:0002600)3.98066929
8Right ventricular cardiomyopathy (HP:0011663)3.79150472
9Muscle fiber inclusion bodies (HP:0100299)3.76289425
10Type 1 muscle fiber predominance (HP:0003803)3.63291125
11Muscle fiber splitting (HP:0003555)3.59876168
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.59161760
13Recurrent bacterial skin infections (HP:0005406)3.57172180
14Recurrent abscess formation (HP:0002722)3.53993974
15Abnormality of macrophages (HP:0004311)3.29419932
16Recurrent gram-negative bacterial infections (HP:0005420)3.23953183
17Myositis (HP:0100614)3.20741285
18Rhabdomyolysis (HP:0003201)3.18922021
19Centrally nucleated skeletal muscle fibers (HP:0003687)3.13429916
20Ulnar deviation of the wrist (HP:0003049)3.13311170
21Orchitis (HP:0100796)3.05447155
22Deep venous thrombosis (HP:0002625)3.02748965
23Difficulty climbing stairs (HP:0003551)3.02086159
24Spontaneous hematomas (HP:0007420)3.01195723
25Ventricular tachycardia (HP:0004756)3.00741901
26Round ear (HP:0100830)2.98826742
27Gastrointestinal infarctions (HP:0005244)2.93818303
28Nemaline bodies (HP:0003798)2.93193908
29Muscle hypertrophy of the lower extremities (HP:0008968)2.92468900
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.85309232
31Muscle stiffness (HP:0003552)2.84259897
32Hypoalphalipoproteinemia (HP:0003233)2.83829510
33EMG: myopathic abnormalities (HP:0003458)2.83287037
34Calf muscle hypertrophy (HP:0008981)2.82988119
35Hypochromic anemia (HP:0001931)2.82975845
36Myopathic facies (HP:0002058)2.77491903
37Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75284965
38Distal arthrogryposis (HP:0005684)2.73509592
39Retrobulbar optic neuritis (HP:0100654)2.73119440
40Optic neuritis (HP:0100653)2.73119440
41Gingivitis (HP:0000230)2.71898712
42Prolonged bleeding time (HP:0003010)2.66249735
43Xanthomatosis (HP:0000991)2.64388183
44Cellulitis (HP:0100658)2.63164060
45Sudden death (HP:0001699)2.62977145
46Increased variability in muscle fiber diameter (HP:0003557)2.61294291
47Abnormality of skeletal muscle fiber size (HP:0012084)2.55770859
48Obstructive lung disease (HP:0006536)2.55123054
49Chronic obstructive pulmonary disease (HP:0006510)2.55123054
50Asymmetric septal hypertrophy (HP:0001670)2.54370570
51Obstructive sleep apnea (HP:0002870)2.50401022
52Intrahepatic cholestasis (HP:0001406)2.49647332
53Abnormality of the left ventricular outflow tract (HP:0011103)2.48085065
54Subaortic stenosis (HP:0001682)2.48085065
55Hypoglycemic coma (HP:0001325)2.48008110
56Hypolipoproteinemia (HP:0010981)2.44951092
57Slow saccadic eye movements (HP:0000514)2.42130248
58Microcytic anemia (HP:0001935)2.41749219
59Increased IgE level (HP:0003212)2.40881778
60Abnormality of the Achilles tendon (HP:0005109)2.40092838
61Multiple enchondromatosis (HP:0005701)2.39615249
62Mildly elevated creatine phosphokinase (HP:0008180)2.39575974
63Reticulocytosis (HP:0001923)2.38201845
64Hyperglycinuria (HP:0003108)2.36417913
65Cerebral aneurysm (HP:0004944)2.36021643
66Abnormality of the fingertips (HP:0001211)2.31024426
67Mediastinal lymphadenopathy (HP:0100721)2.30699824
68Abnormality of monocarboxylic acid metabolism (HP:0010996)2.29238740
69EMG: neuropathic changes (HP:0003445)2.28931219
70Achilles tendon contracture (HP:0001771)2.27905919
71Hyperammonemia (HP:0001987)2.25860473
72Chest pain (HP:0100749)2.25324920
73Hypochromic microcytic anemia (HP:0004840)2.25294654
74Myotonia (HP:0002486)2.24512519
75Keratoconjunctivitis sicca (HP:0001097)2.24346285
76Ankle clonus (HP:0011448)2.23871985
77Urticaria (HP:0001025)2.23749898
78Ventricular fibrillation (HP:0001663)2.23530707
79Pseudobulbar signs (HP:0002200)2.22062189
80Cholelithiasis (HP:0001081)2.21689983
81Meningitis (HP:0001287)2.19877767
82Abnormality of the calf musculature (HP:0001430)2.19576779
83Stomatitis (HP:0010280)2.18739588
84Abnormal cartilage morphology (HP:0002763)2.15853520
85Lymphangioma (HP:0100764)2.13933683
86Cerebral inclusion bodies (HP:0100314)2.13220576
87Back pain (HP:0003418)2.10238183
88Recurrent fungal infections (HP:0002841)2.09718393
89Recurrent skin infections (HP:0001581)2.09504860
90Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.09445105
91Hyperinsulinemic hypoglycemia (HP:0000825)2.09296196
92Hypobetalipoproteinemia (HP:0003563)2.09122583
93Episodic fever (HP:0001954)2.08197285
94Ketosis (HP:0001946)2.07343112
95Ependymoma (HP:0002888)2.06992770
96Epistaxis (HP:0000421)2.05200732
97Pancreatic islet-cell hyperplasia (HP:0004510)2.05200244
98Foot dorsiflexor weakness (HP:0009027)2.05125299
99Gastrointestinal inflammation (HP:0004386)2.04831521
100Gout (HP:0001997)2.03573023
101Amyloidosis (HP:0011034)2.02639486
102Hepatoblastoma (HP:0002884)2.01761141
103Distal lower limb muscle weakness (HP:0009053)2.00329635
104Spastic diplegia (HP:0001264)1.99662128
105Gingival bleeding (HP:0000225)1.99512185
106Abnormality of serine family amino acid metabolism (HP:0010894)1.99160972
107Abnormality of glycine metabolism (HP:0010895)1.99160972
108Inflammation of the large intestine (HP:0002037)1.98555142
109Segmental peripheral demyelination/remyelination (HP:0003481)1.98515266
110Poikilocytosis (HP:0004447)1.97415627
111Absent phalangeal crease (HP:0006109)1.96613876
112Osteomyelitis (HP:0002754)1.94182905
113Broad metatarsal (HP:0001783)1.94104743
114Elevated erythrocyte sedimentation rate (HP:0003565)1.92954946
115Keratoconjunctivitis (HP:0001096)1.92476051
116Toxemia of pregnancy (HP:0100603)1.92274980
117Ketoacidosis (HP:0001993)1.92241889
118Protrusio acetabuli (HP:0003179)1.92125178
119Abnormal gallbladder morphology (HP:0012437)1.92061446
120Abnormality of the lower motor neuron (HP:0002366)1.91287918
121Colitis (HP:0002583)1.91246605
122Resting tremor (HP:0002322)1.91192314
123Neck muscle weakness (HP:0000467)1.90659797
124Abnormality of the foot musculature (HP:0001436)1.90553837
125Aneurysm (HP:0002617)1.90071771
126Vasculitis (HP:0002633)1.89878497
127Abnormality of the calcaneus (HP:0008364)1.88335720
128Distal lower limb amyotrophy (HP:0008944)1.88221528
129Polycythemia (HP:0001901)1.87528737
130Arterial thrombosis (HP:0004420)1.86904301
131Hypoplastic ischia (HP:0003175)1.86257584
132Esophageal varix (HP:0002040)1.83994544
133Calcaneovalgus deformity (HP:0001848)1.83865963
134Paralysis (HP:0003470)1.83803494
135Scapular winging (HP:0003691)1.83018413
136Peritonitis (HP:0002586)1.82715920
137Postural instability (HP:0002172)1.82637525
138Metaphyseal cupping (HP:0003021)1.82492414
139Progressive muscle weakness (HP:0003323)1.82265278
140Encephalitis (HP:0002383)1.80760537
141Shallow orbits (HP:0000586)1.80686897
142Distal upper limb amyotrophy (HP:0007149)1.80305249
143Upper limb amyotrophy (HP:0009129)1.80305249
144Mitral valve prolapse (HP:0001634)1.79457585
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.77348737
146Abnormality of fatty-acid metabolism (HP:0004359)1.76636310
147Visual hallucinations (HP:0002367)1.76336976
148Hyperuricemia (HP:0002149)1.76048464
149Increased purine levels (HP:0004368)1.76048464
150Neurofibrillary tangles (HP:0002185)1.75551324
151Ulnar bowing (HP:0003031)1.75516507
152Frequent falls (HP:0002359)1.75244432
153Skin nodule (HP:0200036)1.73992215
154Abnormality of the ischium (HP:0003174)1.72824340
155Decreased motor nerve conduction velocity (HP:0003431)1.72562980
156Dysmetric saccades (HP:0000641)1.71069932
157Lipoatrophy (HP:0100578)1.70942304
158Abnormality of binocular vision (HP:0011514)1.70612039
159Diplopia (HP:0000651)1.70612039
160Areflexia of lower limbs (HP:0002522)1.70152259
161Rapidly progressive (HP:0003678)1.70100317
162Testicular atrophy (HP:0000029)1.69904059
163Onion bulb formation (HP:0003383)1.69821344
164Supranuclear gaze palsy (HP:0000605)1.69800011
165Abnormal delayed hypersensitivity skin test (HP:0002963)1.69654809
166Abnormal hemoglobin (HP:0011902)1.69654769
167T lymphocytopenia (HP:0005403)1.69493274
168Abnormality of sulfur amino acid metabolism (HP:0004339)1.69015593
169Abnormality of endocrine pancreas physiology (HP:0012093)1.67611269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.37500886
2RIPK43.98209094
3TTN3.88441525
4PRPF4B3.81933854
5PKN23.75836776
6CDK123.53325906
7ERN12.87859107
8MAP3K102.74990462
9EEF2K2.66326855
10OBSCN2.10871845
11NEK12.07729095
12PDGFRA2.06154950
13MAP4K12.04300750
14PTK61.96389875
15RIPK11.89640794
16LATS11.88045827
17BCKDK1.87879940
18BLK1.81767641
19SIK11.73739913
20FES1.72569477
21TNK21.70094707
22TYK21.69400014
23MAP3K111.66296406
24IRAK41.65642611
25GRK61.65031358
26MARK21.64933882
27MAP2K31.61240069
28MAP3K11.58987362
29RPS6KB21.55727371
30MAP3K131.55394922
31STK101.54826105
32MAP3K71.53447194
33TAOK21.52693548
34DDR21.47349384
35PHKG11.47299355
36PHKG21.47299355
37SMG11.45136034
38ICK1.42328306
39TYRO31.41577182
40ZAP701.41504024
41LRRK21.35463661
42TGFBR21.34944585
43PAK41.32011882
44MTOR1.25336767
45FGFR41.23591492
46FGR1.23098932
47MAPKAPK31.22497422
48BMX1.18503785
49FLT31.18329675
50LATS21.14878390
51SGK31.14366794
52HCK1.12365984
53PDK41.07122746
54PDK31.07122746
55BTK1.04296979
56MAP3K60.99932971
57SYK0.98042984
58JAK10.93277952
59TBK10.92465974
60PRKD20.92271557
61CAMK1D0.90864339
62DAPK20.90323225
63JAK30.89572784
64EPHA20.89553048
65MAP3K20.88872929
66ALK0.86961476
67PTK20.85441989
68SGK20.84795419
69MAP3K30.84778405
70DMPK0.84053572
71CDK60.83927364
72EPHB10.83180009
73MAP3K80.81618122
74IKBKE0.81088624
75MAP3K140.78772366
76YES10.73998552
77MAPK120.73258685
78MAPK110.72784031
79SGK2230.71611579
80SGK4940.71611579
81FGFR10.70730725
82CDK40.70579036
83IRAK20.70209439
84CAMKK10.68108954
85STK110.68073797
86PDGFRB0.68051682
87PRKAA20.67856110
88PIK3CG0.66969615
89SIK20.66744235
90HIPK20.66486863
91CSK0.66444893
92NEK20.65446412
93TAOK10.65198779
94PAK20.65179126
95STK30.65083251
96MATK0.64978277
97KSR20.63998206
98PRKG20.63967062
99TTK0.61967692
100CSF1R0.61557866
101RAF10.61290319
102RET0.59702221
103PRKAA10.59616545
104MET0.59540092
105LYN0.59089991
106FGFR30.56903511
107* AKT20.56137136
108GRK50.56120842
109PRKD10.56053957
110RPS6KC10.55887510
111RPS6KL10.55887510
112NEK90.55765003
113MARK30.54367773
114LMTK20.54157839
115CAMK10.53400181
116TIE10.52782470
117STK38L0.52390413
118MAP2K20.51948137
119UHMK10.51620641
120WNK10.51280940
121CAMK1G0.50492137
122DYRK1B0.49405031
123LCK0.49075659
124CDC42BPA0.48916304
125MAPK70.48430328
126FER0.48036405
127FYN0.48017679
128MAP2K40.47964835
129PDK20.47734998
130RPS6KA20.47063103
131JAK20.46973018
132STK380.46353775
133SIK30.46344106
134ILK0.46069074
135GSK3A0.45405488
136ARAF0.44592524
137ITK0.44561292
138SCYL20.43893471
139STK40.43487009
140MAP2K10.43157083
141CAMK40.43029780
142PTK2B0.42775929
143PIK3CA0.41515994
144RPS6KA60.41514540
145TRPM70.41419445
146KSR10.40891662
147PIM10.39717123
148EPHB20.38971464
149PDPK10.36841727
150ERBB20.36610933
151PINK10.36444672
152MAP2K60.36289674
153RPS6KA10.35715279
154CDK70.34546832
155PDK10.34023402

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37195946
2Nitrogen metabolism_Homo sapiens_hsa009103.15369878
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.04718731
4Fatty acid degradation_Homo sapiens_hsa000712.56520449
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49507461
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39351866
7Arginine biosynthesis_Homo sapiens_hsa002202.37046814
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27888280
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20520501
10Osteoclast differentiation_Homo sapiens_hsa043802.19121083
11Propanoate metabolism_Homo sapiens_hsa006402.08049176
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.06296799
13Carbon metabolism_Homo sapiens_hsa012002.03220492
14B cell receptor signaling pathway_Homo sapiens_hsa046622.03169232
15Tryptophan metabolism_Homo sapiens_hsa003801.99341656
16PPAR signaling pathway_Homo sapiens_hsa033201.91749872
17Leishmaniasis_Homo sapiens_hsa051401.89714800
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.88544283
19Lysine degradation_Homo sapiens_hsa003101.74195526
20Biosynthesis of amino acids_Homo sapiens_hsa012301.73120056
21Fatty acid metabolism_Homo sapiens_hsa012121.67356107
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63040785
23Complement and coagulation cascades_Homo sapiens_hsa046101.62995925
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.62407499
25Long-term potentiation_Homo sapiens_hsa047201.54194792
26Starch and sucrose metabolism_Homo sapiens_hsa005001.50758074
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50557015
28Malaria_Homo sapiens_hsa051441.50165971
29Pyruvate metabolism_Homo sapiens_hsa006201.47279048
30Tuberculosis_Homo sapiens_hsa051521.44005001
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43358633
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42494720
33GnRH signaling pathway_Homo sapiens_hsa049121.41584621
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41387845
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40009269
36Butanoate metabolism_Homo sapiens_hsa006501.38789337
37Insulin resistance_Homo sapiens_hsa049311.36963135
38Bile secretion_Homo sapiens_hsa049761.34573276
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34100969
40Fat digestion and absorption_Homo sapiens_hsa049751.29644138
41Neurotrophin signaling pathway_Homo sapiens_hsa047221.27167890
42Pancreatic cancer_Homo sapiens_hsa052121.26523541
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.25418322
44T cell receptor signaling pathway_Homo sapiens_hsa046601.24233386
45Chemokine signaling pathway_Homo sapiens_hsa040621.23917395
46Fructose and mannose metabolism_Homo sapiens_hsa000511.23556017
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.23421839
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22803704
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.21822554
50Galactose metabolism_Homo sapiens_hsa000521.20482848
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.17018902
52Platelet activation_Homo sapiens_hsa046111.16072735
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15552873
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13595267
55Other glycan degradation_Homo sapiens_hsa005111.12360613
56beta-Alanine metabolism_Homo sapiens_hsa004101.11628496
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.11519495
58Selenocompound metabolism_Homo sapiens_hsa004501.11105565
59Dilated cardiomyopathy_Homo sapiens_hsa054141.11041121
60Toxoplasmosis_Homo sapiens_hsa051451.09301555
61AMPK signaling pathway_Homo sapiens_hsa041521.09269085
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07084864
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05872159
64Prolactin signaling pathway_Homo sapiens_hsa049171.05796852
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03647014
66Inositol phosphate metabolism_Homo sapiens_hsa005621.02034274
67Glioma_Homo sapiens_hsa052141.01320795
68Caffeine metabolism_Homo sapiens_hsa002321.00780101
69Hepatitis C_Homo sapiens_hsa051601.00029096
70mTOR signaling pathway_Homo sapiens_hsa041500.99965163
71Phenylalanine metabolism_Homo sapiens_hsa003600.98051643
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.97265875
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96332619
74Measles_Homo sapiens_hsa051620.95476896
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95071791
76ErbB signaling pathway_Homo sapiens_hsa040120.94953540
77Choline metabolism in cancer_Homo sapiens_hsa052310.94633804
78African trypanosomiasis_Homo sapiens_hsa051430.93808735
79Influenza A_Homo sapiens_hsa051640.92074659
80Peroxisome_Homo sapiens_hsa041460.91575593
81Glucagon signaling pathway_Homo sapiens_hsa049220.91160691
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91104071
83Insulin signaling pathway_Homo sapiens_hsa049100.90910571
84Adherens junction_Homo sapiens_hsa045200.90889224
85Focal adhesion_Homo sapiens_hsa045100.89758279
86Hepatitis B_Homo sapiens_hsa051610.88929441
87TNF signaling pathway_Homo sapiens_hsa046680.87851497
88Arginine and proline metabolism_Homo sapiens_hsa003300.87556347
89Endocytosis_Homo sapiens_hsa041440.86624030
90Pentose phosphate pathway_Homo sapiens_hsa000300.86178356
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86173331
92Bladder cancer_Homo sapiens_hsa052190.85424583
93Chemical carcinogenesis_Homo sapiens_hsa052040.84991892
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.84673378
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84660340
96Estrogen signaling pathway_Homo sapiens_hsa049150.83751490
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83727893
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83283978
99* FoxO signaling pathway_Homo sapiens_hsa040680.82814835
100Tight junction_Homo sapiens_hsa045300.82795714
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.81713038
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79878086
103Thyroid cancer_Homo sapiens_hsa052160.79394723
104Glycerolipid metabolism_Homo sapiens_hsa005610.79361616
105Proteoglycans in cancer_Homo sapiens_hsa052050.78889162
106Gastric acid secretion_Homo sapiens_hsa049710.78297417
107Ovarian steroidogenesis_Homo sapiens_hsa049130.75958357
108Oxytocin signaling pathway_Homo sapiens_hsa049210.75778269
109MAPK signaling pathway_Homo sapiens_hsa040100.75105529
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74677347
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73302762
112Apoptosis_Homo sapiens_hsa042100.73053429
113Type II diabetes mellitus_Homo sapiens_hsa049300.72992438
114Sulfur relay system_Homo sapiens_hsa041220.72570024
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.72556942
116One carbon pool by folate_Homo sapiens_hsa006700.71849789
117Small cell lung cancer_Homo sapiens_hsa052220.71817772
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71296825
119ABC transporters_Homo sapiens_hsa020100.69912388
120ECM-receptor interaction_Homo sapiens_hsa045120.69903046
121Histidine metabolism_Homo sapiens_hsa003400.69816073
122Prion diseases_Homo sapiens_hsa050200.69175698
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69012674
124Fatty acid biosynthesis_Homo sapiens_hsa000610.67281922
125Hippo signaling pathway_Homo sapiens_hsa043900.66627971
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66202218
127Hematopoietic cell lineage_Homo sapiens_hsa046400.65955354
128Rap1 signaling pathway_Homo sapiens_hsa040150.64507027
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.63921416
130Chronic myeloid leukemia_Homo sapiens_hsa052200.63739758
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62750967
132Colorectal cancer_Homo sapiens_hsa052100.62396416
133Dorso-ventral axis formation_Homo sapiens_hsa043200.61655945
134Legionellosis_Homo sapiens_hsa051340.61638126
135Phagosome_Homo sapiens_hsa041450.61277646
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61133036
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60526029
138Cholinergic synapse_Homo sapiens_hsa047250.59131362
139Staphylococcus aureus infection_Homo sapiens_hsa051500.58920969
140Pertussis_Homo sapiens_hsa051330.58642154
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58311582
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58231692
143Tyrosine metabolism_Homo sapiens_hsa003500.58218510
144Prostate cancer_Homo sapiens_hsa052150.58081312
145Salmonella infection_Homo sapiens_hsa051320.57621547
146Vitamin B6 metabolism_Homo sapiens_hsa007500.57528894
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.57333735
148Herpes simplex infection_Homo sapiens_hsa051680.57082382
149Drug metabolism - other enzymes_Homo sapiens_hsa009830.55700295
150Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55230836
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52681697
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.52208052
153Graft-versus-host disease_Homo sapiens_hsa053320.52080014
154HIF-1 signaling pathway_Homo sapiens_hsa040660.52012520
155VEGF signaling pathway_Homo sapiens_hsa043700.51881480
156Autoimmune thyroid disease_Homo sapiens_hsa053200.51761579
157Viral myocarditis_Homo sapiens_hsa054160.50604554
158Notch signaling pathway_Homo sapiens_hsa043300.50339667
159Amoebiasis_Homo sapiens_hsa051460.50084913
160Acute myeloid leukemia_Homo sapiens_hsa052210.46467026
161Non-small cell lung cancer_Homo sapiens_hsa052230.46241796
162Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44671052
163Basal cell carcinoma_Homo sapiens_hsa052170.42245342
164MicroRNAs in cancer_Homo sapiens_hsa052060.41725460
165Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39536272
166Steroid hormone biosynthesis_Homo sapiens_hsa001400.39521292
167Retinol metabolism_Homo sapiens_hsa008300.39097634
168Sulfur metabolism_Homo sapiens_hsa009200.38685161
169Renal cell carcinoma_Homo sapiens_hsa052110.36856098
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33536055
171Endometrial cancer_Homo sapiens_hsa052130.33418901
172Vitamin digestion and absorption_Homo sapiens_hsa049770.32023296
173Protein digestion and absorption_Homo sapiens_hsa049740.30181472
174Cyanoamino acid metabolism_Homo sapiens_hsa004600.29911017
175Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29907520

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