FOXN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004 [PubMed 15363391]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)7.51054744
2proline metabolic process (GO:0006560)7.49116632
3embryonic process involved in female pregnancy (GO:0060136)7.24728441
4replication fork processing (GO:0031297)7.14649301
5establishment of apical/basal cell polarity (GO:0035089)6.82869396
6positive regulation of protein homooligomerization (GO:0032464)6.53837664
7microtubule depolymerization (GO:0007019)6.02563701
8regulation of integrin activation (GO:0033623)5.96927876
9establishment of monopolar cell polarity (GO:0061162)5.95948900
10establishment or maintenance of monopolar cell polarity (GO:0061339)5.95948900
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.90715750
12DNA unwinding involved in DNA replication (GO:0006268)5.88398905
13somatic hypermutation of immunoglobulin genes (GO:0016446)5.60818706
14somatic diversification of immune receptors via somatic mutation (GO:0002566)5.60818706
15DNA deamination (GO:0045006)5.53478720
16regulation of protein homooligomerization (GO:0032462)5.51707098
17oxidative demethylation (GO:0070989)5.50790252
18mitotic G1 DNA damage checkpoint (GO:0031571)5.07192452
19regulation of DNA endoreduplication (GO:0032875)5.05458185
20DNA strand renaturation (GO:0000733)5.01556349
21sister chromatid segregation (GO:0000819)4.95361053
22kinetochore organization (GO:0051383)4.94587647
23mitotic sister chromatid segregation (GO:0000070)4.94325163
24mitochondrial DNA metabolic process (GO:0032042)4.93292954
25axonemal dynein complex assembly (GO:0070286)4.80105584
26mitotic chromosome condensation (GO:0007076)4.70126948
27poly(A)+ mRNA export from nucleus (GO:0016973)4.67038170
28G1 DNA damage checkpoint (GO:0044783)4.58192667
29viral mRNA export from host cell nucleus (GO:0046784)4.52640567
30protein localization to kinetochore (GO:0034501)4.50840391
31negative regulation of JAK-STAT cascade (GO:0046426)4.49386797
32mitotic G1/S transition checkpoint (GO:0044819)4.48189788
33embryonic placenta development (GO:0001892)4.45950313
34negative regulation of cell cycle arrest (GO:0071157)4.42565229
35spliceosomal tri-snRNP complex assembly (GO:0000244)4.36423913
36establishment of protein localization to mitochondrial membrane (GO:0090151)4.34310965
37histone H4-K12 acetylation (GO:0043983)4.30692509
38embryonic camera-type eye development (GO:0031076)4.28370041
39negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.21930853
40chromatin remodeling at centromere (GO:0031055)4.20186695
41pyrimidine nucleobase catabolic process (GO:0006208)4.17920790
42protein localization to chromosome, centromeric region (GO:0071459)4.15628817
43regulation of translational fidelity (GO:0006450)4.14579724
44DNA integration (GO:0015074)4.13298418
45cellular response to ATP (GO:0071318)4.09152145
46base-excision repair (GO:0006284)4.08454511
47CENP-A containing nucleosome assembly (GO:0034080)4.08448807
48mRNA cleavage (GO:0006379)4.03546992
49base-excision repair, AP site formation (GO:0006285)4.02672063
50negative regulation of Ras GTPase activity (GO:0034261)4.02619456
51glutamine family amino acid biosynthetic process (GO:0009084)3.97955938
52regulation of gene silencing by RNA (GO:0060966)3.97554346
53regulation of posttranscriptional gene silencing (GO:0060147)3.97554346
54regulation of gene silencing by miRNA (GO:0060964)3.97554346
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.95869671
56convergent extension (GO:0060026)3.91066743
57microtubule polymerization or depolymerization (GO:0031109)3.89431572
58apoptotic process involved in morphogenesis (GO:0060561)3.87686848
59negative regulation of cell cycle G2/M phase transition (GO:1902750)3.83950088
60cellular response to zinc ion (GO:0071294)3.83166636
61cerebral cortex radially oriented cell migration (GO:0021799)3.82360876
62mitotic cell cycle arrest (GO:0071850)3.82323191
63metaphase plate congression (GO:0051310)3.82305928
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.81553863
65regulation of sister chromatid cohesion (GO:0007063)3.81094136
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.79693593
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.79693593
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.79693593
69double-strand break repair via nonhomologous end joining (GO:0006303)3.77750811
70non-recombinational repair (GO:0000726)3.77750811
71mitotic sister chromatid cohesion (GO:0007064)3.77710739
72centriole replication (GO:0007099)3.76287172
73regulation of RNA export from nucleus (GO:0046831)3.75633740
74positive regulation of protein oligomerization (GO:0032461)3.74533304
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74200102
76intraciliary transport (GO:0042073)3.73742108
77positive regulation of developmental pigmentation (GO:0048087)3.73176855
78face development (GO:0060324)3.67096977
79dosage compensation (GO:0007549)3.65885624
80positive regulation by host of viral transcription (GO:0043923)3.64887048
81epithelial cilium movement (GO:0003351)3.63744587
82mitotic metaphase plate congression (GO:0007080)3.61496337
83telomere maintenance via semi-conservative replication (GO:0032201)3.60215227
84formation of translation preinitiation complex (GO:0001731)3.59891121
85DNA topological change (GO:0006265)3.59458186
86cilium movement (GO:0003341)3.59155843
87tongue development (GO:0043586)3.53033667
88negative regulation of protein oligomerization (GO:0032460)3.52308692
89rRNA catabolic process (GO:0016075)3.52178031
90nucleotide-excision repair, DNA gap filling (GO:0006297)3.51942623
91DNA ligation (GO:0006266)3.51809905
92negative regulation of mRNA processing (GO:0050686)3.51745094
93dorsal/ventral axis specification (GO:0009950)3.50168857
94regulation of spindle organization (GO:0090224)3.49991360
95DNA double-strand break processing (GO:0000729)3.47683264
96synapsis (GO:0007129)3.45612898
97regulation of protein oligomerization (GO:0032459)3.45595931
98activation of Rac GTPase activity (GO:0032863)3.44330694
99trophectodermal cell differentiation (GO:0001829)3.41088360
100meiotic chromosome segregation (GO:0045132)3.37414704
101positive regulation of neuroblast proliferation (GO:0002052)3.37235255
102spindle assembly involved in mitosis (GO:0090307)3.36673458
103negative regulation of astrocyte differentiation (GO:0048712)3.36126535
104kinetochore assembly (GO:0051382)3.35870889
105protein localization to chromosome (GO:0034502)3.35755806
106cilium or flagellum-dependent cell motility (GO:0001539)3.34610112
107regulation of centrosome cycle (GO:0046605)3.34602983
108nodal signaling pathway (GO:0038092)3.33327767
109glial cell migration (GO:0008347)3.33088923
110mitochondrial RNA metabolic process (GO:0000959)3.32403943
111regulation of hippo signaling (GO:0035330)3.30151744
112negative regulation of DNA-dependent DNA replication (GO:2000104)3.29922721
113olfactory bulb development (GO:0021772)3.29712833
114regulation of DNA damage checkpoint (GO:2000001)3.29489631
115cell proliferation in forebrain (GO:0021846)3.29409493
116attachment of spindle microtubules to kinetochore (GO:0008608)3.28583322
117regulation of protein polyubiquitination (GO:1902914)3.27582260
118chromosome condensation (GO:0030261)3.27364656
119regulation of double-strand break repair (GO:2000779)3.25594881
120regulation of mitotic spindle organization (GO:0060236)3.25396906
121termination of RNA polymerase II transcription (GO:0006369)3.24093657
122positive regulation of DNA repair (GO:0045739)3.22323941
123negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22177088
124DNA replication-independent nucleosome assembly (GO:0006336)3.22056384
125DNA replication-independent nucleosome organization (GO:0034724)3.22056384
126regulation of double-strand break repair via homologous recombination (GO:0010569)3.21665018
127nucleobase catabolic process (GO:0046113)3.21213447
128regulation of podosome assembly (GO:0071801)3.21134488
129histone exchange (GO:0043486)3.19861325
130regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.17267513
131mitotic nuclear envelope reassembly (GO:0007084)3.17244829
132nuclear envelope reassembly (GO:0031468)3.17244829
133chromosome segregation (GO:0007059)3.15484052
134labyrinthine layer development (GO:0060711)3.14069198
135anatomical structure regression (GO:0060033)3.14011120
136pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.13691844
137chromosome organization involved in meiosis (GO:0070192)3.13552077
138motile cilium assembly (GO:0044458)3.12154341
139negative regulation of RNA splicing (GO:0033119)3.10842086
140DNA replication initiation (GO:0006270)3.09602108
141positive regulation of receptor recycling (GO:0001921)3.07368777
142histone-serine phosphorylation (GO:0035404)3.06480478
143anterior/posterior axis specification, embryo (GO:0008595)3.06118852
144neuronal stem cell maintenance (GO:0097150)3.05884430
145neuron fate determination (GO:0048664)3.05157104
146determination of adult lifespan (GO:0008340)3.04915367
147positive regulation of chromosome segregation (GO:0051984)3.04311483
148epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98779518
149establishment of mitotic spindle localization (GO:0040001)2.98589484
150DNA demethylation (GO:0080111)2.98110236
151nonmotile primary cilium assembly (GO:0035058)2.96417781
152centriole assembly (GO:0098534)2.96261019
153mitotic spindle organization (GO:0007052)2.95829013
154retinal cone cell development (GO:0046549)2.93534488
155centrosome organization (GO:0051297)2.92801409
156negative regulation of chondrocyte differentiation (GO:0032331)2.91972015
157resolution of meiotic recombination intermediates (GO:0000712)2.91431544
158DNA packaging (GO:0006323)2.89336748
159auditory receptor cell stereocilium organization (GO:0060088)2.88722353
160regulation of centrosome duplication (GO:0010824)2.86076147
161histone H2A acetylation (GO:0043968)2.85367817
162regulation of centriole replication (GO:0046599)2.84637782
163retinal rod cell development (GO:0046548)2.83195743
164establishment of chromosome localization (GO:0051303)2.81186053
165cilium organization (GO:0044782)2.80807159
166ATP-dependent chromatin remodeling (GO:0043044)2.78656312
167ectoderm development (GO:0007398)2.77641948
168regulation of cell cycle G2/M phase transition (GO:1902749)2.77306893
169chromatin assembly or disassembly (GO:0006333)2.76491749
170cilium assembly (GO:0042384)2.76297386
171mitotic recombination (GO:0006312)2.75313703
172protein polyglutamylation (GO:0018095)2.75174013
173regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.75159064
174protein K6-linked ubiquitination (GO:0085020)2.74919496
175microtubule organizing center organization (GO:0031023)2.73520891
176microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.71731210
177DNA synthesis involved in DNA repair (GO:0000731)2.70814042
178spindle checkpoint (GO:0031577)2.70644776
179sister chromatid cohesion (GO:0007062)2.70370920
180positive regulation of neural precursor cell proliferation (GO:2000179)2.69458387
181male meiosis (GO:0007140)2.68433471
182peptidyl-lysine dimethylation (GO:0018027)2.66991158
183male meiosis I (GO:0007141)2.65012485
184regulation of chromosome segregation (GO:0051983)2.64703249
185meiotic nuclear division (GO:0007126)2.60826454
186hindbrain development (GO:0030902)2.60097167
187viral transcription (GO:0019083)2.59585149
188meiotic cell cycle process (GO:1903046)2.58706335
189proline biosynthetic process (GO:0006561)10.0808244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63860962
2SMAD1_18555785_ChIP-Seq_MESCs_Mouse4.02350499
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.00896828
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.00896828
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.00896828
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.73534080
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.16458162
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.99092275
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.97654434
10E2F7_22180533_ChIP-Seq_HELA_Human2.97631210
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.96047400
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.77369430
13NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.65164327
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.48394721
15TCF3_18692474_ChIP-Seq_MESCs_Mouse2.48366286
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.48021899
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44744262
18KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.42540391
19POU5F1_16518401_ChIP-PET_MESCs_Mouse2.36626324
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.32971089
21SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.31698025
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26396055
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.24688378
24FOXM1_23109430_ChIP-Seq_U2OS_Human2.23356778
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21531534
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.21411851
27VDR_21846776_ChIP-Seq_THP-1_Human2.16331930
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.13076499
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03547615
30ERG_21242973_ChIP-ChIP_JURKAT_Human2.01025858
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00421058
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.96414282
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.94490486
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.92949070
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88904888
36AR_21909140_ChIP-Seq_LNCAP_Human1.86926525
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.86105997
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.84409307
39RNF2_27304074_Chip-Seq_NSC_Mouse1.83037532
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.79929910
41NANOG_21062744_ChIP-ChIP_HESCs_Human1.79065025
42* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.78673271
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76014860
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75895212
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75520855
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71648498
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69801896
48* LXR_22292898_ChIP-Seq_THP-1_Human1.69766772
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.69604088
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68194741
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66407224
52ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65679436
53SOX2_18555785_ChIP-Seq_MESCs_Mouse1.64877383
54* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64297271
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62403504
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61650682
57NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.59295346
58EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59153442
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.58207722
60RNF2_27304074_Chip-Seq_ESCs_Mouse1.55559026
61* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54942564
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53452532
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53452532
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53415784
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52965785
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52897464
67POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.52764731
68SOX2_18692474_ChIP-Seq_MESCs_Mouse1.51483434
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.51150653
70* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49904128
71* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.49538023
72NANOG_18692474_ChIP-Seq_MESCs_Mouse1.49499621
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48514648
74PU.1_20513432_ChIP-Seq_Bcells_Mouse1.46789457
75ZNF263_19887448_ChIP-Seq_K562_Human1.45444752
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.44870113
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.42986284
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42831953
79EWS_26573619_Chip-Seq_HEK293_Human1.41896924
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40644212
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.40036874
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38028238
83RACK7_27058665_Chip-Seq_MCF-7_Human1.37128769
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.36540057
85TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.34883284
86RNF2_18974828_ChIP-Seq_MESCs_Mouse1.32373553
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.32373553
88PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.30552828
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30256439
90* TET1_21451524_ChIP-Seq_MESCs_Mouse1.30191889
91* EZH2_27294783_Chip-Seq_ESCs_Mouse1.30123606
92* REST_21632747_ChIP-Seq_MESCs_Mouse1.29462334
93FUS_26573619_Chip-Seq_HEK293_Human1.28181709
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26682596
95MYC_22102868_ChIP-Seq_BL_Human1.26011493
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25245542
97* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22789365
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22055418
99OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21116297
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20878672
101IRF1_19129219_ChIP-ChIP_H3396_Human1.19748623
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19235534
103* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19205197
104NANOG_18692474_ChIP-Seq_MEFs_Mouse1.18454321
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18262849
106KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16949264
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16805653
108MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16402652
109KDM2B_26808549_Chip-Seq_DND41_Human1.16370236
110POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.15802682
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14398366
112POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14301209
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13203280
114KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12488567
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.11850735
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11778700
117RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11088457
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10343015
119GBX2_23144817_ChIP-Seq_PC3_Human1.10272447
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.10024668
121* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.09690892
122TP53_20018659_ChIP-ChIP_R1E_Mouse1.09402247
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09047340
124ZNF274_21170338_ChIP-Seq_K562_Hela1.08971231
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08787131
126KAP1_27257070_Chip-Seq_ESCs_Mouse1.08577612
127SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08281166
128* NANOG_16518401_ChIP-PET_MESCs_Mouse1.08097910
129NELFA_20434984_ChIP-Seq_ESCs_Mouse1.07942981
130SOX2_16153702_ChIP-ChIP_HESCs_Human1.07937500
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07409798
132KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07390068
133KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06648515
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05880794
135EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05693102
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04592807
137ETS1_21867929_ChIP-Seq_TH2_Mouse1.04556564
138RING1B_27294783_Chip-Seq_ESCs_Mouse1.04409830
139PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03668407
140YY1_21170310_ChIP-Seq_MESCs_Mouse1.03321356
141* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01826651
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01260863
143MYC_18940864_ChIP-ChIP_HL60_Human1.00973188
144TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00946096
145TBL1_22424771_ChIP-Seq_293T_Human1.00916621
146SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00390855
147CDX2_20551321_ChIP-Seq_CACO-2_Human0.99182512
148RARB_24833708_ChIP-Seq_LIVER_Mouse0.98741056
149* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98497740
150CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97814750
151VDR_22108803_ChIP-Seq_LS180_Human0.97404449
152KDM2B_26808549_Chip-Seq_K562_Human0.95425035
153DROSHA_22980978_ChIP-Seq_HELA_Human0.94913092
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.94782266
155TAF15_26573619_Chip-Seq_HEK293_Human0.94441712
156CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94311866
157TTF2_22483619_ChIP-Seq_HELA_Human0.93556246
158RARA_24833708_ChIP-Seq_LIVER_Mouse0.93138636
159P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93023114
160SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92780884
161CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92150329
162HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91277154
163IGF1R_20145208_ChIP-Seq_DFB_Human0.91167665
164CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90694450
165SOX9_26525672_Chip-Seq_HEART_Mouse0.89551567
166* NFYB_21822215_ChIP-Seq_K562_Human0.89231555
167MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89191717
168RING1B_27294783_Chip-Seq_NPCs_Mouse0.88247674
169SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87957049
170WDR5_24793694_ChIP-Seq_LNCAP_Human0.87182377
171* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.86714412
172CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85700114
173OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84943722
174XRN2_22483619_ChIP-Seq_HELA_Human0.84875356
175* CTCF_27219007_Chip-Seq_Bcells_Human0.83278103
176* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83240554
177* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.82181935
178TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82023073
179LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81870956
180TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81556339
181GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81510815
182SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81023711
183CBP_20019798_ChIP-Seq_JUKART_Human0.78033721
184IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78033721
185NFYA_21822215_ChIP-Seq_K562_Human0.77187479
186PHF8_20622853_ChIP-Seq_HELA_Human0.76235338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.78839267
2MP0005171_absent_coat_pigmentation4.28907038
3MP0009278_abnormal_bone_marrow4.19127673
4MP0010030_abnormal_orbit_morphology4.13695614
5MP0000566_synostosis4.01267356
6MP0002009_preneoplasia3.38424425
7MP0004233_abnormal_muscle_weight3.10251437
8MP0003283_abnormal_digestive_organ3.09644635
9MP0008789_abnormal_olfactory_epithelium3.01880507
10MP0009379_abnormal_foot_pigmentation2.98692155
11MP0002653_abnormal_ependyma_morphology2.92848407
12MP0003890_abnormal_embryonic-extraembry2.64379259
13MP0005394_taste/olfaction_phenotype2.51864628
14MP0005499_abnormal_olfactory_system2.51864628
15MP0000778_abnormal_nervous_system2.47441602
16MP0010094_abnormal_chromosome_stability2.37936528
17MP0008995_early_reproductive_senescence2.36153034
18MP0004133_heterotaxia2.30031570
19MP0003119_abnormal_digestive_system2.26578994
20MP0002822_catalepsy2.09488601
21MP0002249_abnormal_larynx_morphology2.09095417
22MP0001293_anophthalmia2.08498183
23MP0003453_abnormal_keratinocyte_physiol2.07038154
24MP0001545_abnormal_hematopoietic_system1.93665797
25MP0005397_hematopoietic_system_phenotyp1.93665797
26MP0005076_abnormal_cell_differentiation1.92687537
27MP0002234_abnormal_pharynx_morphology1.91631321
28* MP0005253_abnormal_eye_physiology1.88656564
29MP0003786_premature_aging1.82789741
30MP0002282_abnormal_trachea_morphology1.82354428
31MP0004957_abnormal_blastocyst_morpholog1.78457997
32MP0002638_abnormal_pupillary_reflex1.78126435
33MP0000579_abnormal_nail_morphology1.69924908
34MP0002796_impaired_skin_barrier1.69171579
35MP0008877_abnormal_DNA_methylation1.66650101
36MP0002084_abnormal_developmental_patter1.65997153
37MP0000631_abnormal_neuroendocrine_gland1.64719804
38MP0003567_abnormal_fetal_cardiomyocyte1.60388946
39MP0010352_gastrointestinal_tract_polyps1.58132157
40MP0002938_white_spotting1.56838549
41MP0008058_abnormal_DNA_repair1.55750070
42MP0002086_abnormal_extraembryonic_tissu1.54863561
43MP0008932_abnormal_embryonic_tissue1.53368821
44MP0001346_abnormal_lacrimal_gland1.53244076
45MP0003111_abnormal_nucleus_morphology1.51497053
46MP0002085_abnormal_embryonic_tissue1.51369012
47MP0004197_abnormal_fetal_growth/weight/1.51159307
48MP0005174_abnormal_tail_pigmentation1.50439947
49MP0001697_abnormal_embryo_size1.45988673
50* MP0005195_abnormal_posterior_eye1.45320811
51MP0003880_abnormal_central_pattern1.45010769
52* MP0006072_abnormal_retinal_apoptosis1.41968329
53MP0003136_yellow_coat_color1.39968360
54MP0000762_abnormal_tongue_morphology1.39163359
55MP0003937_abnormal_limbs/digits/tail_de1.37482743
56MP0002111_abnormal_tail_morphology1.37203643
57MP0005551_abnormal_eye_electrophysiolog1.36442653
58MP0001340_abnormal_eyelid_morphology1.35703229
59MP0000569_abnormal_digit_pigmentation1.35506796
60MP0000470_abnormal_stomach_morphology1.35406061
61MP0002210_abnormal_sex_determination1.31306547
62MP0003938_abnormal_ear_development1.31197595
63MP0005377_hearing/vestibular/ear_phenot1.30233467
64MP0003878_abnormal_ear_physiology1.30233467
65MP0000462_abnormal_digestive_system1.29432758
66MP0000026_abnormal_inner_ear1.29220419
67MP0002233_abnormal_nose_morphology1.29086177
68MP0003077_abnormal_cell_cycle1.27693588
69MP0000490_abnormal_crypts_of1.26340897
70MP0001929_abnormal_gametogenesis1.23748088
71MP0001672_abnormal_embryogenesis/_devel1.21715511
72MP0005380_embryogenesis_phenotype1.21715511
73MP0002160_abnormal_reproductive_system1.20378360
74MP0001485_abnormal_pinna_reflex1.16628375
75MP0003755_abnormal_palate_morphology1.15682409
76MP0003698_abnormal_male_reproductive1.14750002
77MP0004264_abnormal_extraembryonic_tissu1.13401757
78MP0005501_abnormal_skin_physiology1.12137976
79MP0002697_abnormal_eye_size1.11359788
80MP0000653_abnormal_sex_gland1.11298586
81MP0000350_abnormal_cell_proliferation1.10945632
82MP0002557_abnormal_social/conspecific_i1.09903065
83MP0000371_diluted_coat_color1.09617920
84MP0001502_abnormal_circadian_rhythm1.08937306
85MP0005187_abnormal_penis_morphology1.08749500
86* MP0002752_abnormal_somatic_nervous1.06683011
87MP0003121_genomic_imprinting1.06624786
88MP0005248_abnormal_Harderian_gland1.03549661
89MP0000467_abnormal_esophagus_morphology1.03425676
90MP0004742_abnormal_vestibular_system1.03232859
91MP0003935_abnormal_craniofacial_develop1.01879369
92MP0002736_abnormal_nociception_after1.00344529
93MP0001984_abnormal_olfaction0.98862525
94MP0009053_abnormal_anal_canal0.98654782
95MP0000383_abnormal_hair_follicle0.97228516
96MP0003941_abnormal_skin_development0.96906863
97MP0001730_embryonic_growth_arrest0.96794710
98MP0002060_abnormal_skin_morphology0.96012869
99MP0001299_abnormal_eye_distance/0.96009339
100MP0000955_abnormal_spinal_cord0.95623955
101MP0010234_abnormal_vibrissa_follicle0.95491951
102MP0002269_muscular_atrophy0.94679871
103MP0001963_abnormal_hearing_physiology0.94634561
104MP0003828_pulmonary_edema0.94098988
105MP0003718_maternal_effect0.93887851
106MP0002080_prenatal_lethality0.92813519
107MP0003693_abnormal_embryo_hatching0.92450951
108MP0006276_abnormal_autonomic_nervous0.92424832
109MP0002152_abnormal_brain_morphology0.91198361
110MP0000432_abnormal_head_morphology0.91165768
111MP0002116_abnormal_craniofacial_bone0.89371135
112MP0005423_abnormal_somatic_nervous0.89176970
113MP0002019_abnormal_tumor_incidence0.88600499
114MP0002932_abnormal_joint_morphology0.88503314
115MP0002751_abnormal_autonomic_nervous0.88365592
116MP0005075_abnormal_melanosome_morpholog0.88152158
117MP0003984_embryonic_growth_retardation0.87554584
118MP0002114_abnormal_axial_skeleton0.87540806
119MP0000639_abnormal_adrenal_gland0.87382856
120MP0000049_abnormal_middle_ear0.86246390
121MP0000428_abnormal_craniofacial_morphol0.86224987
122MP0003385_abnormal_body_wall0.85545881
123MP0002088_abnormal_embryonic_growth/wei0.84963890
124* MP0002882_abnormal_neuron_morphology0.84378950
125MP0002184_abnormal_innervation0.83915927
126MP0004885_abnormal_endolymph0.83711844
127MP0000516_abnormal_urinary_system0.83302060
128MP0005367_renal/urinary_system_phenotyp0.83302060
129MP0010307_abnormal_tumor_latency0.82884802
130MP0001119_abnormal_female_reproductive0.82792650
131MP0005389_reproductive_system_phenotype0.82093709
132MP0001529_abnormal_vocalization0.81873240
133MP0002075_abnormal_coat/hair_pigmentati0.81666339
134MP0003705_abnormal_hypodermis_morpholog0.80953713
135MP0001324_abnormal_eye_pigmentation0.80072754
136MP0002161_abnormal_fertility/fecundity0.78538005
137MP0003646_muscle_fatigue0.77387265
138MP0006292_abnormal_olfactory_placode0.77301163
139MP0003861_abnormal_nervous_system0.76890750
140MP0009697_abnormal_copulation0.75624668
141MP0000647_abnormal_sebaceous_gland0.75342748
142MP0000534_abnormal_ureter_morphology0.75245310
143MP0000015_abnormal_ear_pigmentation0.74577652
144MP0003122_maternal_imprinting0.74516343
145MP0000372_irregular_coat_pigmentation0.74385706
146MP0010368_abnormal_lymphatic_system0.74267327
147MP0002092_abnormal_eye_morphology0.73605199
148MP0000427_abnormal_hair_cycle0.73547843
149MP0001186_pigmentation_phenotype0.72175662
150MP0003942_abnormal_urinary_system0.72048022
151MP0002109_abnormal_limb_morphology0.71418262
152* MP0005391_vision/eye_phenotype0.70867564
153MP0001286_abnormal_eye_development0.70403390
154MP0003137_abnormal_impulse_conducting0.69667030
155MP0004142_abnormal_muscle_tone0.69143180
156MP0001145_abnormal_male_reproductive0.68297405
157MP0003936_abnormal_reproductive_system0.67700390
158MP0005266_abnormal_metabolism0.66979360
159MP0003172_abnormal_lysosome_physiology0.66116305
160MP0010678_abnormal_skin_adnexa0.63799423
161MP0010630_abnormal_cardiac_muscle0.62931220

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.59545691
2Concave nail (HP:0001598)5.16771375
3Facial hemangioma (HP:0000329)4.86347238
4Annular pancreas (HP:0001734)4.73180616
5Pustule (HP:0200039)4.64246883
6Rectal fistula (HP:0100590)4.60365208
7Rectovaginal fistula (HP:0000143)4.60365208
8Alopecia of scalp (HP:0002293)4.43820689
9Turricephaly (HP:0000262)4.33567817
10Increased IgM level (HP:0003496)4.19925709
11Intestinal fistula (HP:0100819)4.09786911
12Coronal craniosynostosis (HP:0004440)4.06494139
13Vaginal fistula (HP:0004320)4.04022689
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95631657
15Intestinal atresia (HP:0011100)3.93753120
16Poikiloderma (HP:0001029)3.91966988
17Chromsome breakage (HP:0040012)3.90950788
18Ulnar bowing (HP:0003031)3.81484545
19Ectopic kidney (HP:0000086)3.75951661
20Alacrima (HP:0000522)3.68901360
21Short humerus (HP:0005792)3.65066190
22Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.64348202
23Hypochromic microcytic anemia (HP:0004840)3.58264847
24Absent radius (HP:0003974)3.57798356
25Orthostatic hypotension (HP:0001278)3.53923364
26Aplasia/hypoplasia of the humerus (HP:0006507)3.51752560
27Abnormal hemoglobin (HP:0011902)3.45889533
28Aplasia involving forearm bones (HP:0009822)3.36834074
29Absent forearm bone (HP:0003953)3.36834074
30Premature skin wrinkling (HP:0100678)3.35887134
31Tongue fasciculations (HP:0001308)3.35433082
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30986915
33Hypotrichosis (HP:0001006)3.30527375
34Male infertility (HP:0003251)3.26675482
35Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.25284020
36Vertebral hypoplasia (HP:0008417)3.25284020
37Abnormal ciliary motility (HP:0012262)3.23506226
38Oligodactyly (HP:0012165)3.21634348
39Abnormal respiratory motile cilium physiology (HP:0012261)3.19852233
40Dysautonomia (HP:0002459)3.09373452
41Squamous cell carcinoma (HP:0002860)3.09073206
42Abnormality of midbrain morphology (HP:0002418)3.05618933
43Molar tooth sign on MRI (HP:0002419)3.05618933
44Muscle fibrillation (HP:0010546)3.05231100
45Oligodactyly (hands) (HP:0001180)3.02597710
46Anteriorly placed anus (HP:0001545)3.02064126
47Gastrointestinal atresia (HP:0002589)2.97246100
48Short chin (HP:0000331)2.93634919
49Pendular nystagmus (HP:0012043)2.93364964
50Abnormality of male internal genitalia (HP:0000022)2.92748822
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.89437163
52Absent/shortened dynein arms (HP:0200106)2.89437163
53Decreased lacrimation (HP:0000633)2.87284607
54Hamartoma (HP:0010566)2.87122041
55Duplicated collecting system (HP:0000081)2.86768218
56Hypochromic anemia (HP:0001931)2.83970919
57Absent thumb (HP:0009777)2.83554236
58Chronic hepatic failure (HP:0100626)2.82071623
59Cortical dysplasia (HP:0002539)2.81085035
60Volvulus (HP:0002580)2.80407104
61Broad alveolar ridges (HP:0000187)2.78243223
62Abnormality of the aortic arch (HP:0012303)2.77685485
63Selective tooth agenesis (HP:0001592)2.76817688
64Short 4th metacarpal (HP:0010044)2.73558966
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73558966
66Duplication of thumb phalanx (HP:0009942)2.73142241
67Congenital hip dislocation (HP:0001374)2.72462157
68Abnormality of the labia minora (HP:0012880)2.71830395
69Reticulocytopenia (HP:0001896)2.70235983
70Septo-optic dysplasia (HP:0100842)2.66168563
71Basal cell carcinoma (HP:0002671)2.64879104
72Abnormality of the renal collecting system (HP:0004742)2.64757335
73Aplasia of the musculature (HP:0100854)2.61251609
74Patellar aplasia (HP:0006443)2.59709845
75Increased nuchal translucency (HP:0010880)2.57986416
76Anophthalmia (HP:0000528)2.57066131
77Rhinitis (HP:0012384)2.52798153
78Cerebellar dysplasia (HP:0007033)2.50407738
79Astrocytoma (HP:0009592)2.50229616
80Abnormality of the astrocytes (HP:0100707)2.50229616
81Hypoplastic iliac wings (HP:0002866)2.48299214
82Amelogenesis imperfecta (HP:0000705)2.47842467
83Esophageal atresia (HP:0002032)2.46956326
84Hypotelorism (HP:0000601)2.44968533
85Abnormality of the phalanges of the hallux (HP:0010057)2.40995537
86Nephronophthisis (HP:0000090)2.40626126
87Choanal stenosis (HP:0000452)2.38377048
88Growth hormone excess (HP:0000845)2.35432263
89Pancreatic islet-cell hyperplasia (HP:0004510)2.35413907
90Aplasia/Hypoplasia of the patella (HP:0006498)2.34955565
91Large for gestational age (HP:0001520)2.34927873
92Abnormality of DNA repair (HP:0003254)2.34285537
93Abnormality of the 4th metacarpal (HP:0010012)2.28630002
94Premature graying of hair (HP:0002216)2.27340395
95True hermaphroditism (HP:0010459)2.26727180
96Cutaneous finger syndactyly (HP:0010554)2.25108358
97Bifid uvula (HP:0000193)2.24426258
98Capillary hemangiomas (HP:0005306)2.23998112
99Urinary glycosaminoglycan excretion (HP:0003541)2.23505082
100Mucopolysacchariduria (HP:0008155)2.23505082
101Popliteal pterygium (HP:0009756)2.22448223
102Vertebral fusion (HP:0002948)2.21841216
103Medial flaring of the eyebrow (HP:0010747)2.20453030
104Hypoplasia of the ulna (HP:0003022)2.20127452
105Gait imbalance (HP:0002141)2.20085318
106Diaphragmatic weakness (HP:0009113)2.19546048
107Triphalangeal thumb (HP:0001199)2.18844114
108Congenital primary aphakia (HP:0007707)2.18012878
109Split hand (HP:0001171)2.17795541
110Neoplasm of the oral cavity (HP:0100649)2.16372485
111Increased number of teeth (HP:0011069)2.15947148
112Abnormal lung lobation (HP:0002101)2.15278918
113Pancreatic fibrosis (HP:0100732)2.14646676
114Abnormality of abdominal situs (HP:0011620)2.14508286
115Abdominal situs inversus (HP:0003363)2.14508286
116High anterior hairline (HP:0009890)2.14236479
117Albinism (HP:0001022)2.13190771
118Narrow nasal bridge (HP:0000446)2.12873482
119Preaxial hand polydactyly (HP:0001177)2.12687185
120Supernumerary spleens (HP:0009799)2.11794760
121Abnormal number of incisors (HP:0011064)2.11450160
12211 pairs of ribs (HP:0000878)2.10873959
123Clumsiness (HP:0002312)2.10294788
124Postaxial foot polydactyly (HP:0001830)2.09015442
125Hypoplasia of the radius (HP:0002984)2.07976210
126Cutaneous syndactyly (HP:0012725)2.07271518
127Poor coordination (HP:0002370)2.07012780
128Broad distal phalanx of finger (HP:0009836)2.06268971
129Horseshoe kidney (HP:0000085)2.05462414
130Truncal obesity (HP:0001956)2.04928368
131Cerebral aneurysm (HP:0004944)2.04049283
132Shawl scrotum (HP:0000049)2.02968778
133Abnormal respiratory epithelium morphology (HP:0012253)2.01762019
134Abnormal respiratory motile cilium morphology (HP:0005938)2.01762019
135Joint stiffness (HP:0001387)1.98974569
136Abnormality of the intervertebral disk (HP:0005108)1.98348275
137Median cleft lip (HP:0000161)1.97683287
138Bowed forearm bones (HP:0003956)1.97394023
139Bowing of the arm (HP:0006488)1.97394023
140Abnormality of the antihelix (HP:0009738)1.97293706
141Abnormality of the diencephalon (HP:0010662)1.96876620
142Abnormality of polysaccharide metabolism (HP:0011012)1.96769206
143Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96769206
144Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96769206
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.94793767
146Abnormality of the renal medulla (HP:0100957)1.94715351
147Aplasia/Hypoplasia of the sternum (HP:0006714)1.94184518
148IgA deficiency (HP:0002720)1.93481989
149Nephrogenic diabetes insipidus (HP:0009806)1.93446937
150Hyperglycinemia (HP:0002154)1.92409995
151Holoprosencephaly (HP:0001360)1.91821081
152Optic nerve hypoplasia (HP:0000609)1.90749899
153Ependymoma (HP:0002888)1.89451946
154Dysostosis multiplex (HP:0000943)1.89014172
155Postaxial hand polydactyly (HP:0001162)1.88476337
156Pancreatic cysts (HP:0001737)1.87575316
157Abnormal sex determination (HP:0012244)1.86814930
158Sex reversal (HP:0012245)1.86814930
159Partial agenesis of the corpus callosum (HP:0001338)1.86721806
160Sclerocornea (HP:0000647)1.86124103
161Cheilitis (HP:0100825)1.85780374
162Anencephaly (HP:0002323)1.85048442
163Hypoplastic pelvis (HP:0008839)1.84464249
164Abnormality of the ileum (HP:0001549)1.84368397
165Sloping forehead (HP:0000340)1.84179300
166Type II lissencephaly (HP:0007260)1.84161649
167Tubulointerstitial nephritis (HP:0001970)1.84035144
168Aplasia/Hypoplasia of the ulna (HP:0006495)1.83042919
169Retinal dysplasia (HP:0007973)1.83014892
170Morphological abnormality of the inner ear (HP:0011390)1.81303645
171Double outlet right ventricle (HP:0001719)1.81204398
172Congenital malformation of the right heart (HP:0011723)1.81204398
173Absent septum pellucidum (HP:0001331)1.81074834
174Abnormality of pyrimidine metabolism (HP:0004353)1.80345082
175Occipital encephalocele (HP:0002085)1.80062201
176Bifid scrotum (HP:0000048)1.79999379
177Vitreoretinal degeneration (HP:0000655)1.79678094
178Meckel diverticulum (HP:0002245)1.76063247
179Impulsivity (HP:0100710)1.75752750
180Vaginal atresia (HP:0000148)1.75659680
181Short thumb (HP:0009778)1.72769169
182Small hand (HP:0200055)1.71408715
183Genital tract atresia (HP:0001827)1.71386691
184Abnormality of chromosome segregation (HP:0002916)1.71064957
185Partial duplication of thumb phalanx (HP:0009944)1.71004220
186Aplasia/Hypoplasia of the spleen (HP:0010451)1.70566954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.86726955
2MAPK155.62546493
3DDR24.87414392
4MAP3K64.35170547
5BRSK24.17660176
6PNCK3.53227334
7EPHA43.07698892
8FGR2.99958830
9PINK12.97487017
10TYRO32.90338260
11MAP3K112.86488226
12MATK2.81804672
13UHMK12.58642832
14DYRK1B2.46036724
15BRSK12.37317219
16PLK42.35179052
17INSRR2.27000684
18DAPK12.22313814
19BMX2.21689471
20YES12.21087397
21MAP3K42.04344498
22CSK1.92867263
23PRKD21.92830957
24PDGFRA1.89704455
25EPHB21.85728213
26AKT31.83363410
27PIM21.75664914
28ZAK1.74557453
29CDK71.73542740
30CASK1.72662395
31IRAK11.66922842
32CDK191.64525512
33PLK31.63963956
34CDK61.61506485
35EPHA21.60054433
36TRPM71.48620443
37PBK1.46989915
38STK161.45738195
39PIM11.44982194
40LATS21.39929275
41CCNB11.31549634
42RPS6KL11.27795422
43RPS6KC11.27795422
44VRK11.27018779
45MAP4K21.26910284
46GSK3A1.19306344
47CHEK21.18524991
48CDK81.15098868
49VRK21.13920586
50SRPK11.12849874
51CDK91.10132905
52CDC42BPA1.07491586
53RPS6KA61.06563882
54PKN11.04726533
55PLK11.01564648
56MKNK21.00469623
57DYRK30.99549376
58NTRK30.96071642
59PHKG20.95272631
60PHKG10.95272631
61MARK30.95196527
62ERBB20.94751910
63ERBB30.93738386
64MAP3K100.92650035
65CAMK1G0.90544836
66CDK120.88806746
67PRPF4B0.87185621
68MAPK110.86160962
69WNK40.81800785
70RPS6KB20.81652932
71HIPK20.80520320
72MKNK10.80056716
73BRAF0.78946351
74BCR0.76600549
75STK40.76116694
76CDC70.75211090
77RPS6KA10.73771382
78FRK0.71810132
79STK110.68582343
80MTOR0.68476583
81PRKAA10.67688300
82PASK0.67451610
83OXSR10.66118914
84NEK20.65090602
85CDK30.64740257
86WEE10.64268975
87MELK0.63008432
88KSR10.61387428
89ATR0.59946631
90TIE10.59260525
91AURKA0.58934908
92CAMK40.58561774
93NUAK10.56659277
94CDK20.56091775
95CDK11A0.55329526
96NTRK20.55128329
97CDK150.51706783
98MAP2K40.50688386
99FGFR20.49266751
100MINK10.48660628
101CDK180.48195001
102MAP3K80.48148915
103STK390.47739272
104MAP3K70.47679335
105CAMKK10.47118741
106WNK30.46893805
107BRD40.46683374
108TAOK20.46343966
109SGK4940.45404996
110SGK2230.45404996
111TAF10.45365640
112CSNK2A10.45199247
113CAMK1D0.44553828
114MAP2K70.44533851
115EGFR0.44408074
116CSNK1G10.44334053
117MAPK10.43489538
118MAP2K20.43022483
119WNK10.41428676
120DYRK20.41384145
121MAPK30.40775396
122TLK10.40732489
123MAPK100.40699092
124MAPK130.39953403
125BMPR1B0.39840953
126ATM0.39330525
127RPS6KB10.38844904
128TSSK60.38278197
129DYRK1A0.38053706
130CHEK10.37909869
131MAP3K90.37455471
132AURKB0.37092636
133MAPK140.36705205
134CDK140.36512742
135PRKCG0.36256096
136PDGFRB0.35155123
137ALK0.34313463
138LATS10.34122886
139CDK10.33253340
140STK100.32755866
141CHUK0.32569783
142RIPK10.31157223
143CSNK2A20.30199388
144TTK0.29711404
145PRKAA20.29503870
146RAF10.29227204
147CAMK2B0.29188801
148MAPK90.29171519
149SGK10.28005193
150FGFR10.27815600
151LYN0.27028078
152NEK10.26449433
153MAPKAPK30.26421330
154INSR0.25430914
155STK30.25371706
156CAMK2A0.24687296
157AKT10.24440086
158PAK20.23608874
159MAPK40.23373674
160CDK40.21710224
161CSNK1E0.21709257
162CAMK2G0.20741822
163GSK3B0.19788842
164BUB10.19381777
165RPS6KA30.19152099
166PRKDC0.18255378
167MAPKAPK20.18135440

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.21474789
2Mismatch repair_Homo sapiens_hsa034304.98117579
3Base excision repair_Homo sapiens_hsa034104.62658412
4DNA replication_Homo sapiens_hsa030303.54734586
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38511727
6Notch signaling pathway_Homo sapiens_hsa043302.37885794
7Nucleotide excision repair_Homo sapiens_hsa034202.36190119
8Spliceosome_Homo sapiens_hsa030402.27784199
9Hippo signaling pathway_Homo sapiens_hsa043902.23050919
10Hedgehog signaling pathway_Homo sapiens_hsa043402.20849648
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.20163097
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17761569
13mRNA surveillance pathway_Homo sapiens_hsa030152.12516238
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.00929320
15Circadian rhythm_Homo sapiens_hsa047101.98329784
16mTOR signaling pathway_Homo sapiens_hsa041501.96694794
17RNA transport_Homo sapiens_hsa030131.93919514
18Adherens junction_Homo sapiens_hsa045201.80920769
19Fanconi anemia pathway_Homo sapiens_hsa034601.80488627
20p53 signaling pathway_Homo sapiens_hsa041151.78158882
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77902940
22Non-homologous end-joining_Homo sapiens_hsa034501.73055193
23Bladder cancer_Homo sapiens_hsa052191.71819795
24Arginine and proline metabolism_Homo sapiens_hsa003301.69437633
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.66995480
26Homologous recombination_Homo sapiens_hsa034401.66972448
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66492143
28Basal cell carcinoma_Homo sapiens_hsa052171.60928836
29Phototransduction_Homo sapiens_hsa047441.59154114
30Cell cycle_Homo sapiens_hsa041101.56651708
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47832870
32TGF-beta signaling pathway_Homo sapiens_hsa043501.47701395
33Butanoate metabolism_Homo sapiens_hsa006501.46840950
34Wnt signaling pathway_Homo sapiens_hsa043101.43838414
35Biosynthesis of amino acids_Homo sapiens_hsa012301.39685600
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.38954668
37Dorso-ventral axis formation_Homo sapiens_hsa043201.38372820
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.28464864
39Protein export_Homo sapiens_hsa030601.26125168
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23753991
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23198628
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19202772
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.18647693
44Sulfur relay system_Homo sapiens_hsa041221.16056492
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12831578
46RNA polymerase_Homo sapiens_hsa030201.12293095
47One carbon pool by folate_Homo sapiens_hsa006701.05413117
48Oocyte meiosis_Homo sapiens_hsa041141.04657502
49Colorectal cancer_Homo sapiens_hsa052101.04260128
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03632340
51MicroRNAs in cancer_Homo sapiens_hsa052061.02352697
52Tight junction_Homo sapiens_hsa045301.00135572
53Lysine degradation_Homo sapiens_hsa003100.99263704
54Fatty acid metabolism_Homo sapiens_hsa012120.99043409
55Retinol metabolism_Homo sapiens_hsa008300.97073267
56Pyrimidine metabolism_Homo sapiens_hsa002400.94330744
57Nicotine addiction_Homo sapiens_hsa050330.94197511
58VEGF signaling pathway_Homo sapiens_hsa043700.93971849
59Folate biosynthesis_Homo sapiens_hsa007900.93339387
60Viral carcinogenesis_Homo sapiens_hsa052030.89553337
61Propanoate metabolism_Homo sapiens_hsa006400.89447388
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87058397
63Small cell lung cancer_Homo sapiens_hsa052220.86118175
64Huntingtons disease_Homo sapiens_hsa050160.83716073
65Systemic lupus erythematosus_Homo sapiens_hsa053220.83368007
66Peroxisome_Homo sapiens_hsa041460.83228014
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.81485033
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79364217
69Linoleic acid metabolism_Homo sapiens_hsa005910.78895781
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78727248
71ErbB signaling pathway_Homo sapiens_hsa040120.78321513
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77382570
73Axon guidance_Homo sapiens_hsa043600.76265442
74Fructose and mannose metabolism_Homo sapiens_hsa000510.74537722
75ABC transporters_Homo sapiens_hsa020100.74079541
76Thyroid cancer_Homo sapiens_hsa052160.73755243
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73380411
78Viral myocarditis_Homo sapiens_hsa054160.71872586
79Shigellosis_Homo sapiens_hsa051310.70235980
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69422912
81Fatty acid degradation_Homo sapiens_hsa000710.67915726
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66544253
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66001202
84Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65021709
85Cocaine addiction_Homo sapiens_hsa050300.64611110
86Taste transduction_Homo sapiens_hsa047420.63995859
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63638955
88Arginine biosynthesis_Homo sapiens_hsa002200.62848710
89Ribosome_Homo sapiens_hsa030100.61300054
90Chemical carcinogenesis_Homo sapiens_hsa052040.60665480
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.60488596
92Chronic myeloid leukemia_Homo sapiens_hsa052200.59339565
93Gap junction_Homo sapiens_hsa045400.59149709
94AMPK signaling pathway_Homo sapiens_hsa041520.57896141
95Tryptophan metabolism_Homo sapiens_hsa003800.55253212
96Proteoglycans in cancer_Homo sapiens_hsa052050.53439003
97Acute myeloid leukemia_Homo sapiens_hsa052210.53418438
98Endometrial cancer_Homo sapiens_hsa052130.51580007
99Cyanoamino acid metabolism_Homo sapiens_hsa004600.51557018
100Choline metabolism in cancer_Homo sapiens_hsa052310.50845645
101Selenocompound metabolism_Homo sapiens_hsa004500.50717058
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49370246
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49345591
104Purine metabolism_Homo sapiens_hsa002300.48766745
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47980458
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45347558
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43996967
108Basal transcription factors_Homo sapiens_hsa030220.42367447
109HTLV-I infection_Homo sapiens_hsa051660.42183091
110Ovarian steroidogenesis_Homo sapiens_hsa049130.42075609
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.41406956
112Bile secretion_Homo sapiens_hsa049760.41310781
113Metabolic pathways_Homo sapiens_hsa011000.40417185
114Olfactory transduction_Homo sapiens_hsa047400.40063509
115Pathways in cancer_Homo sapiens_hsa052000.39930415
116FoxO signaling pathway_Homo sapiens_hsa040680.38495598
117Glutathione metabolism_Homo sapiens_hsa004800.38194436
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.38168094
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37939985
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37544707
121Primary immunodeficiency_Homo sapiens_hsa053400.36795018
122Alcoholism_Homo sapiens_hsa050340.36413519
123Steroid biosynthesis_Homo sapiens_hsa001000.36347695
124Insulin signaling pathway_Homo sapiens_hsa049100.35890470
125MAPK signaling pathway_Homo sapiens_hsa040100.35766723
126RNA degradation_Homo sapiens_hsa030180.35414899
127Glutamatergic synapse_Homo sapiens_hsa047240.35216036
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34437646
129Ether lipid metabolism_Homo sapiens_hsa005650.30330401
130Prostate cancer_Homo sapiens_hsa052150.30255421
131Focal adhesion_Homo sapiens_hsa045100.29734651
132Arachidonic acid metabolism_Homo sapiens_hsa005900.29631706
133Morphine addiction_Homo sapiens_hsa050320.29535892
134Cholinergic synapse_Homo sapiens_hsa047250.28256429
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26871870
136Inositol phosphate metabolism_Homo sapiens_hsa005620.26784825
137GABAergic synapse_Homo sapiens_hsa047270.25608065
138Galactose metabolism_Homo sapiens_hsa000520.25587510
139Regulation of autophagy_Homo sapiens_hsa041400.25374146
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23865883
141Legionellosis_Homo sapiens_hsa051340.23268390
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23058323
143Epstein-Barr virus infection_Homo sapiens_hsa051690.22809589
144Estrogen signaling pathway_Homo sapiens_hsa049150.21790044
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21434749
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.21050393
147GnRH signaling pathway_Homo sapiens_hsa049120.20579366
148Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20473994
149Melanoma_Homo sapiens_hsa052180.20243102
150Mineral absorption_Homo sapiens_hsa049780.19132897
151Endocytosis_Homo sapiens_hsa041440.17018594
152Melanogenesis_Homo sapiens_hsa049160.16792246
153Hepatitis B_Homo sapiens_hsa051610.16511223

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