FOXJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry. Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1primary alcohol catabolic process (GO:0034310)8.38148671
2glomerular filtration (GO:0003094)7.39449796
3cilium movement (GO:0003341)7.33888240
4cilium or flagellum-dependent cell motility (GO:0001539)7.26613601
5vitamin transmembrane transport (GO:0035461)7.06841579
6renal filtration (GO:0097205)7.03438601
7ethanol metabolic process (GO:0006067)6.86773936
8microtubule bundle formation (GO:0001578)6.68569302
9axonemal dynein complex assembly (GO:0070286)6.56021381
10intraciliary transport (GO:0042073)6.45475309
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.39950340
12diterpenoid biosynthetic process (GO:0016102)6.20289941
13glomerular basement membrane development (GO:0032836)6.20275480
14epithelial cilium movement (GO:0003351)6.17336281
15* left/right pattern formation (GO:0060972)6.15701836
16* cilium organization (GO:0044782)5.80815919
17axon extension involved in axon guidance (GO:0048846)5.77049258
18neuron projection extension involved in neuron projection guidance (GO:1902284)5.77049258
19* cilium assembly (GO:0042384)5.64085189
20response to xenobiotic stimulus (GO:0009410)5.51506158
21pyrimidine-containing compound transmembrane transport (GO:0072531)5.46398596
22centriole assembly (GO:0098534)5.34340307
23ethanol oxidation (GO:0006069)5.27785902
24negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.17415747
25sperm capacitation (GO:0048240)5.09609310
26protein localization to cilium (GO:0061512)5.09364908
27retinal ganglion cell axon guidance (GO:0031290)5.04550524
28astrocyte differentiation (GO:0048708)4.82190975
29chondrocyte development (GO:0002063)4.78253035
30microtubule-based movement (GO:0007018)4.77592852
31regulation of interleukin-5 production (GO:0032674)4.74032050
32dendritic spine morphogenesis (GO:0060997)4.57127938
33lung lobe morphogenesis (GO:0060463)4.54401391
34* cellular component assembly involved in morphogenesis (GO:0010927)4.50507779
35regulation of interleukin-13 production (GO:0032656)4.42123087
36negative regulation of axon guidance (GO:1902668)4.38264720
37retinoic acid metabolic process (GO:0042573)4.35508471
38terpenoid biosynthetic process (GO:0016114)4.30862381
39ventricular system development (GO:0021591)4.28855341
40negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)4.24845504
41motile cilium assembly (GO:0044458)4.23389086
42negative regulation of leukocyte chemotaxis (GO:0002689)4.23342135
43* cell projection assembly (GO:0030031)4.16785299
44microtubule depolymerization (GO:0007019)4.14961832
45axonal fasciculation (GO:0007413)4.12201925
46regulation of chemokine-mediated signaling pathway (GO:0070099)4.11955204
47branching involved in salivary gland morphogenesis (GO:0060445)4.10236800
48left/right axis specification (GO:0070986)4.01494136
49axoneme assembly (GO:0035082)4.01161078
50cytoplasmic microtubule organization (GO:0031122)4.00872358
51camera-type eye morphogenesis (GO:0048593)4.00598028
52establishment of planar polarity (GO:0001736)3.96639433
53establishment of tissue polarity (GO:0007164)3.96639433
54innervation (GO:0060384)3.90177454
55neuronal action potential propagation (GO:0019227)3.88861641
56microtubule polymerization or depolymerization (GO:0031109)3.85006914
57nucleoside diphosphate phosphorylation (GO:0006165)3.84478426
58regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.78154013
59positive regulation of BMP signaling pathway (GO:0030513)3.69951446
60lung-associated mesenchyme development (GO:0060484)3.68900919
61astrocyte development (GO:0014002)3.65425984
62central nervous system myelination (GO:0022010)3.59844882
63axon ensheathment in central nervous system (GO:0032291)3.59844882
64primary alcohol metabolic process (GO:0034308)3.55444798
65embryonic foregut morphogenesis (GO:0048617)3.55320538
66establishment of nucleus localization (GO:0040023)3.52167292
67positive regulation of oligodendrocyte differentiation (GO:0048714)3.50684947
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.50468331
69negative regulation of axon extension (GO:0030517)3.50236169
70neuronal ion channel clustering (GO:0045161)3.45084103
71* lung epithelium development (GO:0060428)3.45019888
72retinol metabolic process (GO:0042572)3.43370709
73exogenous drug catabolic process (GO:0042738)3.42955692
74* cilium morphogenesis (GO:0060271)3.41924611
75lateral ventricle development (GO:0021670)3.39533606
76epithelial cell differentiation involved in prostate gland development (GO:0060742)3.39103868
77regulation of axon guidance (GO:1902667)3.37177518
78limb bud formation (GO:0060174)3.36782999
79O-glycan processing (GO:0016266)3.33442521
80eye photoreceptor cell differentiation (GO:0001754)3.29870381
81photoreceptor cell differentiation (GO:0046530)3.29870381
82negative regulation of inclusion body assembly (GO:0090084)3.26233700
83cell proliferation involved in metanephros development (GO:0072203)3.25011146
84glutathione derivative metabolic process (GO:1901685)3.24875646
85glutathione derivative biosynthetic process (GO:1901687)3.24875646
86sperm motility (GO:0030317)3.22846313
87hydrogen peroxide biosynthetic process (GO:0050665)3.21884308
88acrosome reaction (GO:0007340)3.19329357
89negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.18673004
90regulation of microtubule depolymerization (GO:0031114)3.18096998
91multicellular organismal water homeostasis (GO:0050891)3.15374180
92neuroblast proliferation (GO:0007405)3.12738915
93neuron fate determination (GO:0048664)3.12617086
94aldehyde catabolic process (GO:0046185)3.12308577
95regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.10209164
96negative chemotaxis (GO:0050919)3.09272414
97regulation of cilium movement (GO:0003352)3.07982972
98negative regulation of embryonic development (GO:0045992)3.07957693
99neuronal stem cell maintenance (GO:0097150)3.07286704
100midbrain development (GO:0030901)3.07216934
101regulation of mesenchymal cell apoptotic process (GO:2001053)3.05538717
102lens fiber cell development (GO:0070307)3.04038491
103endocardial cushion morphogenesis (GO:0003203)3.03034794
104mesenchymal cell proliferation (GO:0010463)3.01765850
105phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.00947945
106neuron recognition (GO:0008038)2.98487904
107hippo signaling (GO:0035329)2.97436898
108dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.95682947
109determination of left/right symmetry (GO:0007368)2.94901791
110negative regulation of vascular permeability (GO:0043116)2.93801071
111renal system development (GO:0072001)2.92584966
112epithelial tube branching involved in lung morphogenesis (GO:0060441)2.91330449
113ectoderm development (GO:0007398)2.91001581
114G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.87429697
115layer formation in cerebral cortex (GO:0021819)2.86809800
116negative regulation of smooth muscle cell migration (GO:0014912)2.85282509
117reactive oxygen species biosynthetic process (GO:1903409)2.85126030
118negative regulation of axonogenesis (GO:0050771)2.84971947
119microtubule-based process (GO:0007017)2.84920978
120calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84145774
121determination of bilateral symmetry (GO:0009855)2.83732904
122heparan sulfate proteoglycan metabolic process (GO:0030201)2.83020583
123carnitine metabolic process (GO:0009437)2.82607872
124smoothened signaling pathway (GO:0007224)2.81830520
125progesterone metabolic process (GO:0042448)2.81139952
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.80989393
127hydrogen peroxide catabolic process (GO:0042744)2.80188518
128peptidyl-tyrosine autophosphorylation (GO:0038083)2.79149638
129excretion (GO:0007588)2.78219509
130specification of symmetry (GO:0009799)2.77670838
131artery development (GO:0060840)2.77596154
132positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.77500454
133epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.77156641
134dopaminergic neuron differentiation (GO:0071542)2.74753313
135centriole replication (GO:0007099)2.74060118
136surfactant homeostasis (GO:0043129)2.73770296
137mesenchyme morphogenesis (GO:0072132)2.72807830
138phosphatidylcholine biosynthetic process (GO:0006656)2.72332908
139regulation of autophagic vacuole assembly (GO:2000785)2.71520402
140regulation of oligodendrocyte differentiation (GO:0048713)2.71144695
141one-carbon compound transport (GO:0019755)2.69638510
142regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)2.69613946
143regulation of microtubule-based movement (GO:0060632)2.67792974
144ear development (GO:0043583)2.67342664
145regulation of response to osmotic stress (GO:0047484)2.67049236
146water homeostasis (GO:0030104)2.66725174
147axon extension (GO:0048675)2.66705365
148apical protein localization (GO:0045176)2.66134909
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.65979862
150regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.64738251
151regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.63659711
152lateral sprouting from an epithelium (GO:0060601)2.60641604
153oligosaccharide biosynthetic process (GO:0009312)2.60617585
154negative regulation of microtubule depolymerization (GO:0007026)2.59779492
155drug catabolic process (GO:0042737)2.58348451
156regulation of inclusion body assembly (GO:0090083)2.57708568
157hypotonic response (GO:0006971)2.57645489
158regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.57447587
159hair follicle development (GO:0001942)2.57277521
160sodium ion homeostasis (GO:0055078)2.57023518
161polyol transport (GO:0015791)2.56812361
162asymmetric protein localization (GO:0008105)2.56707948
163planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56226938
164regulation of mononuclear cell migration (GO:0071675)2.55312071
165fusion of sperm to egg plasma membrane (GO:0007342)2.55252451
166regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.54077780
167positive regulation of gastrulation (GO:2000543)2.53545069
168embryonic camera-type eye development (GO:0031076)2.53043845
169positive regulation of smoothened signaling pathway (GO:0045880)2.52502669
170regulation of apoptotic cell clearance (GO:2000425)2.51473852
171heart looping (GO:0001947)2.50830454
172CDP-diacylglycerol biosynthetic process (GO:0016024)2.50817436
173* organelle assembly (GO:0070925)2.49193584
174regulation of smoothened signaling pathway (GO:0008589)2.47034627
175hydrogen peroxide metabolic process (GO:0042743)2.43078968
176retinal rod cell development (GO:0046548)2.38488931
177regulation of cilium assembly (GO:1902017)2.37896726
178protein O-linked glycosylation (GO:0006493)2.36528948
179glutathione metabolic process (GO:0006749)2.35448753
180protein refolding (GO:0042026)2.33168848

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.63100281
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.33996098
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.96776595
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.78568764
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54284012
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.43024989
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.34964772
8DROSHA_22980978_ChIP-Seq_HELA_Human2.32116521
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.31731481
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19248750
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19248750
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.17345193
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.08525521
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07718505
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.00935810
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99887409
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.98453491
18* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.98283851
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.97271722
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.95905558
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95824096
22* EZH2_27294783_Chip-Seq_ESCs_Mouse1.92600450
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.90831905
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90321756
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.88476328
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.85216403
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84782525
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82199534
29PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.80664996
30FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.78435774
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75680150
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72218171
33STAT1_20625510_ChIP-Seq_HELA_Human1.71675669
34PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.70123128
35AHR_22903824_ChIP-Seq_MCF-7_Human1.64683962
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.63378989
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63117376
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.57813618
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56486012
40* TP63_22573176_ChIP-Seq_HFKS_Human1.55848170
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54901406
42RING1B_27294783_Chip-Seq_ESCs_Mouse1.54823607
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.53175821
44* KLF5_25053715_ChIP-Seq_YYC3_Human1.52780108
45RAD21_21589869_ChIP-Seq_MESCs_Mouse1.52418597
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50278341
47P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49823780
48ESR1_20079471_ChIP-ChIP_T-47D_Human1.49593715
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.48109863
50TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47113163
51GATA1_26923725_Chip-Seq_HPCs_Mouse1.46405754
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46361281
53WT1_25993318_ChIP-Seq_PODOCYTE_Human1.45792280
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44794779
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44548482
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43626550
57* TP63_23658742_ChIP-Seq_EP156T_Human1.43284278
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41781353
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.41016311
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40648275
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40594678
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39221009
63* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39014531
64SOX2_20726797_ChIP-Seq_SW620_Human1.38661796
65GATA1_19941826_ChIP-Seq_K562_Human1.36132635
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34866731
67* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34364407
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34306531
69RACK7_27058665_Chip-Seq_MCF-7_Human1.34220090
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33747884
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.32243403
72P68_20966046_ChIP-Seq_HELA_Human1.31774014
73EP300_21415370_ChIP-Seq_HL-1_Mouse1.31473197
74TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30802789
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30770463
76TP63_17297297_ChIP-ChIP_HaCaT_Human1.30245918
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.28101781
78FOXA1_25552417_ChIP-Seq_VCAP_Human1.27497009
79CREB1_26743006_Chip-Seq_LNCaP_Human1.26676260
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25381205
81* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.25271004
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24560868
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24398287
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24036385
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23197786
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21593240
87ETV1_20927104_ChIP-Seq_GIST48_Human1.21452709
88REST_21632747_ChIP-Seq_MESCs_Mouse1.21442974
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21317015
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21273504
91CTCF_20526341_ChIP-Seq_ESCs_Human1.20906591
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.20825473
93LXR_22292898_ChIP-Seq_THP-1_Human1.20569499
94YY1_22570637_ChIP-Seq_MALME-3M_Human1.20342642
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20117080
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19649622
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.18541499
98* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18240495
99CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16243129
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15522761
101PHF8_20622854_ChIP-Seq_HELA_Human1.14520858
102PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.12913178
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.11990012
104SMRT_27268052_Chip-Seq_Bcells_Human1.11900328
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11345640
106SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10739032
107KDM2B_26808549_Chip-Seq_K562_Human1.10409427
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09845272
109CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09726156
110HNFA_21074721_ChIP-Seq_CACO-2_Human1.09637396
111PHF8_20622853_ChIP-Seq_HELA_Human1.09304551
112TAF15_26573619_Chip-Seq_HEK293_Human1.09073556
113STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08621911
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07976619
115VDR_22108803_ChIP-Seq_LS180_Human1.07631407
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04940603
117ZNF263_19887448_ChIP-Seq_K562_Human1.04224190
118GATA3_24758297_ChIP-Seq_MCF-7_Human1.04148814
119RARB_27405468_Chip-Seq_BRAIN_Mouse1.03846455
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02875426
121* PIAS1_25552417_ChIP-Seq_VCAP_Human1.02678717
122SMAD4_21741376_ChIP-Seq_HESCs_Human1.02369636
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02202619
124GATA4_25053715_ChIP-Seq_YYC3_Human1.02189202
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02081551
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01585187
127CJUN_26792858_Chip-Seq_BT549_Human1.01015215
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99884881
129* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.99138896
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.98936915
131RBPJ_21746931_ChIP-Seq_IB4_Human0.98145986
132* FOXA2_19822575_ChIP-Seq_HepG2_Human0.97441341
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.97242293
134MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.97217851
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97150195
136CBX2_22325352_ChIP-Seq_293T-Rex_Human0.95131826
137NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94284138
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.93871761
139CTCF_27219007_Chip-Seq_Bcells_Human0.93545610
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93155534
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92445994
142AR_19668381_ChIP-Seq_PC3_Human0.92264028
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.91853497
144P300_27268052_Chip-Seq_Bcells_Human0.91516577
145SOX2_21211035_ChIP-Seq_LN229_Human0.90346244
146* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90328976
147GATA6_21074721_ChIP-Seq_CACO-2_Human0.90176296
148* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89906510
149E2F1_20622854_ChIP-Seq_HELA_Human0.89633068
150SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89489424
151REST_18959480_ChIP-ChIP_MESCs_Mouse0.88141749
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87661316
153NFYA_21822215_ChIP-Seq_K562_Human0.87626249
154SMC4_20622854_ChIP-Seq_HELA_Human0.87426167
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87396461
156GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86555165
157CEBPB_22108803_ChIP-Seq_LS180_Human0.86354086
158MYC_27129775_Chip-Seq_CORNEA_Mouse0.86159317
159TP53_18474530_ChIP-ChIP_U2OS_Human0.85801789
160ZNF274_21170338_ChIP-Seq_K562_Hela0.85728686
161CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85515531
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.84813227
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.84417398
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84261890
165WDR5_24793694_ChIP-Seq_LNCAP_Human0.83455598
166RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83079279
167P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82966833
168NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82721587
169GATA2_19941826_ChIP-Seq_K562_Human0.82714689
170* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82442049
171BCOR_27268052_Chip-Seq_Bcells_Human0.81611680
172* FLI1_21867929_ChIP-Seq_CD8_Mouse0.81565079
173SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80927615

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok7.09083753
2MP0002132_abnormal_respiratory_system5.58274850
3MP0002653_abnormal_ependyma_morphology4.66548763
4MP0000537_abnormal_urethra_morphology4.46402983
5MP0003283_abnormal_digestive_organ4.40922747
6MP0004043_abnormal_pH_regulation3.79192738
7MP0005410_abnormal_fertilization3.42741558
8MP0002234_abnormal_pharynx_morphology3.31360446
9MP0008789_abnormal_olfactory_epithelium3.27333894
10MP0000467_abnormal_esophagus_morphology2.98697930
11MP0000778_abnormal_nervous_system2.73193259
12MP0002282_abnormal_trachea_morphology2.63858993
13MP0005623_abnormal_meninges_morphology2.60166437
14MP0003878_abnormal_ear_physiology2.54400466
15MP0005377_hearing/vestibular/ear_phenot2.54400466
16MP0003942_abnormal_urinary_system2.48086943
17MP0000534_abnormal_ureter_morphology2.22292699
18MP0005499_abnormal_olfactory_system2.22193445
19MP0005394_taste/olfaction_phenotype2.22193445
20MP0004019_abnormal_vitamin_homeostasis2.22051235
21MP0005167_abnormal_blood-brain_barrier2.16527311
22MP0004858_abnormal_nervous_system2.07905405
23MP0001293_anophthalmia1.92479939
24MP0004859_abnormal_synaptic_plasticity1.90312367
25MP0002249_abnormal_larynx_morphology1.89768316
26MP0003136_yellow_coat_color1.89647884
27MP0000462_abnormal_digestive_system1.88005519
28* MP0003634_abnormal_glial_cell1.87438028
29MP0003115_abnormal_respiratory_system1.84612881
30MP0000566_synostosis1.81848461
31MP0005083_abnormal_biliary_tract1.81507251
32MP0009053_abnormal_anal_canal1.76749346
33MP0000678_abnormal_parathyroid_gland1.73318919
34MP0004742_abnormal_vestibular_system1.70918577
35MP0001765_abnormal_ion_homeostasis1.68704963
36MP0003656_abnormal_erythrocyte_physiolo1.68330595
37MP0009384_cardiac_valve_regurgitation1.67029427
38MP0001346_abnormal_lacrimal_gland1.65509306
39MP0000955_abnormal_spinal_cord1.64853665
40MP0002160_abnormal_reproductive_system1.59997876
41MP0003690_abnormal_glial_cell1.59939384
42* MP0004133_heterotaxia1.58806854
43MP0004885_abnormal_endolymph1.58676370
44MP0009379_abnormal_foot_pigmentation1.51896095
45MP0002102_abnormal_ear_morphology1.50220474
46MP0005076_abnormal_cell_differentiation1.49901835
47MP0000428_abnormal_craniofacial_morphol1.49891225
48MP0009780_abnormal_chondrocyte_physiolo1.49424473
49MP0002092_abnormal_eye_morphology1.48018359
50MP0005381_digestive/alimentary_phenotyp1.47551854
51MP0001958_emphysema1.46895640
52MP0003938_abnormal_ear_development1.43469602
53MP0003122_maternal_imprinting1.42735654
54MP0001299_abnormal_eye_distance/1.41615200
55MP0003329_amyloid_beta_deposits1.41479661
56MP0000026_abnormal_inner_ear1.40504998
57MP0010678_abnormal_skin_adnexa1.39486192
58MP0004782_abnormal_surfactant_physiolog1.39327649
59MP0000383_abnormal_hair_follicle1.38567660
60MP0004272_abnormal_basement_membrane1.31565746
61MP0000920_abnormal_myelination1.28865338
62MP0000049_abnormal_middle_ear1.26119690
63MP0005165_increased_susceptibility_to1.25861464
64* MP0003861_abnormal_nervous_system1.25446171
65MP0003937_abnormal_limbs/digits/tail_de1.23774792
66MP0001663_abnormal_digestive_system1.21703414
67MP0004233_abnormal_muscle_weight1.20218250
68MP0003950_abnormal_plasma_membrane1.19670747
69MP0002932_abnormal_joint_morphology1.19034716
70MP0010030_abnormal_orbit_morphology1.18719732
71MP0000631_abnormal_neuroendocrine_gland1.13628545
72MP0002233_abnormal_nose_morphology1.13284859
73MP0002734_abnormal_mechanical_nocicepti1.12749148
74MP0003698_abnormal_male_reproductive1.12423039
75MP0003635_abnormal_synaptic_transmissio1.12203984
76MP0003880_abnormal_central_pattern1.10608776
77MP0005636_abnormal_mineral_homeostasis1.10094796
78* MP0002152_abnormal_brain_morphology1.08320014
79MP0002751_abnormal_autonomic_nervous1.07385849
80MP0000681_abnormal_thyroid_gland1.07037713
81MP0002277_abnormal_respiratory_mucosa1.06086447
82MP0000465_gastrointestinal_hemorrhage1.06032239
83MP0002882_abnormal_neuron_morphology1.04967064
84MP0010155_abnormal_intestine_physiology1.03918583
85MP0002116_abnormal_craniofacial_bone1.02876175
86MP0002184_abnormal_innervation1.02125535
87MP0005391_vision/eye_phenotype1.01465407
88MP0002909_abnormal_adrenal_gland1.00821250
89MP0004264_abnormal_extraembryonic_tissu0.98242593
90MP0005388_respiratory_system_phenotype0.97550801
91MP0002133_abnormal_respiratory_system0.97550801
92MP0005248_abnormal_Harderian_gland0.95576363
93MP0001943_abnormal_respiration0.95563271
94MP0002638_abnormal_pupillary_reflex0.95376310
95MP0001849_ear_inflammation0.93961260
96MP0002876_abnormal_thyroid_physiology0.93599658
97MP0003300_gastrointestinal_ulcer0.92616496
98MP0002254_reproductive_system_inflammat0.91886656
99MP0002735_abnormal_chemical_nociception0.88389692
100MP0008004_abnormal_stomach_pH0.87814261
101MP0002064_seizures0.87562202
102MP0002295_abnormal_pulmonary_circulatio0.87519697
103MP0001177_atelectasis0.87227941
104MP0002697_abnormal_eye_size0.85945265
105MP0001984_abnormal_olfaction0.85886420
106MP0003315_abnormal_perineum_morphology0.85127774
107MP0001485_abnormal_pinna_reflex0.84280957
108MP0003453_abnormal_keratinocyte_physiol0.83586660
109MP0003091_abnormal_cell_migration0.82820925
110MP0002098_abnormal_vibrissa_morphology0.82514365
111MP0005164_abnormal_response_to0.82065847
112MP0004270_analgesia0.81380002
113MP0003137_abnormal_impulse_conducting0.79628242
114MP0009643_abnormal_urine_homeostasis0.79508891
115MP0002063_abnormal_learning/memory/cond0.78017970
116MP0004883_abnormal_blood_vessel0.77537538
117MP0002752_abnormal_somatic_nervous0.75472978
118MP0002136_abnormal_kidney_physiology0.75459577
119MP0005508_abnormal_skeleton_morphology0.75235377
120MP0005408_hypopigmentation0.75016580
121MP0008961_abnormal_basal_metabolism0.74825772
122MP0001286_abnormal_eye_development0.73966007
123* MP0001929_abnormal_gametogenesis0.73870970
124MP0003633_abnormal_nervous_system0.71246651
125MP0010234_abnormal_vibrissa_follicle0.70694469
126MP0005365_abnormal_bile_salt0.70583402
127MP0004811_abnormal_neuron_physiology0.70458401
128MP0002557_abnormal_social/conspecific_i0.68473815
129MP0002822_catalepsy0.68396353
130MP0002896_abnormal_bone_mineralization0.68133550
131MP0001502_abnormal_circadian_rhythm0.67991704
132* MP0002161_abnormal_fertility/fecundity0.67441027
133MP0003303_peritoneal_inflammation0.66390857
134MP0000647_abnormal_sebaceous_gland0.66195008
135MP0003755_abnormal_palate_morphology0.65800850
136MP0003632_abnormal_nervous_system0.65698891
137MP0001270_distended_abdomen0.63740755
138MP0005389_reproductive_system_phenotype0.62776586
139MP0009765_abnormal_xenobiotic_induced0.62230674
140MP0005409_darkened_coat_color0.62148541
141MP0005503_abnormal_tendon_morphology0.61124678
142MP0005220_abnormal_exocrine_pancreas0.60923522
143MP0003075_altered_response_to0.59147743
144MP0001944_abnormal_pancreas_morphology0.54458252
145MP0003866_abnormal_defecation0.53968084
146MP0009046_muscle_twitch0.52804490
147* MP0002168_other_aberrant_phenotype0.52167346
148MP0002405_respiratory_system_inflammati0.51625955
149MP0005023_abnormal_wound_healing0.51533874
150MP0009763_increased_sensitivity_to0.49837113
151MP0001664_abnormal_digestion0.49358503
152MP0002928_abnormal_bile_duct0.48417900
153MP0001324_abnormal_eye_pigmentation0.48269387
154MP0001963_abnormal_hearing_physiology0.47053979
155MP0002139_abnormal_hepatobiliary_system0.46230454
156MP0000858_altered_metastatic_potential0.45979043
157MP0003890_abnormal_embryonic-extraembry0.45569081
158MP0005085_abnormal_gallbladder_physiolo0.44130650
159MP0005310_abnormal_salivary_gland0.43514834
160MP0001879_abnormal_lymphatic_vessel0.42241655

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.39349148
2Abnormal respiratory motile cilium physiology (HP:0012261)7.90511601
3Abnormal ciliary motility (HP:0012262)7.41099448
4Abnormal respiratory epithelium morphology (HP:0012253)6.83152492
5Abnormal respiratory motile cilium morphology (HP:0005938)6.83152492
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.41076751
7Absent/shortened dynein arms (HP:0200106)6.41076751
8Rhinitis (HP:0012384)6.20114704
9Chronic bronchitis (HP:0004469)5.84631383
10Male infertility (HP:0003251)3.96537942
11Bronchiectasis (HP:0002110)3.89437075
12Megalencephaly (HP:0001355)3.72301970
13Maternal diabetes (HP:0009800)3.68191939
14Occipital encephalocele (HP:0002085)3.59424051
15Pancreatic fibrosis (HP:0100732)3.31040200
16Nasal polyposis (HP:0100582)3.20186191
17Abnormality of the nasal mucosa (HP:0000433)3.17237130
18Chronic otitis media (HP:0000389)3.09786441
19Neurofibrillary tangles (HP:0002185)2.98921050
20Diaphragmatic weakness (HP:0009113)2.91906390
21Septo-optic dysplasia (HP:0100842)2.86754024
22Bronchomalacia (HP:0002780)2.84005847
23Mesangial abnormality (HP:0001966)2.76806694
24Bronchitis (HP:0012387)2.63796423
25Shallow orbits (HP:0000586)2.63641570
26Pancreatic cysts (HP:0001737)2.60245334
27Infertility (HP:0000789)2.57746905
28Broad distal phalanx of finger (HP:0009836)2.49902227
29Tubular atrophy (HP:0000092)2.49722797
30Cerebral inclusion bodies (HP:0100314)2.45243914
31Chronic hepatic failure (HP:0100626)2.42385818
32Postaxial foot polydactyly (HP:0001830)2.34722914
33Tubulointerstitial fibrosis (HP:0005576)2.22879704
34Abnormality of dentin (HP:0010299)2.17975304
35Arnold-Chiari malformation (HP:0002308)2.06450020
36Synostosis of carpal bones (HP:0005048)2.05437242
37Short nail (HP:0001799)2.02341731
38Prenatal maternal abnormality (HP:0002686)2.00495589
39Chronic sinusitis (HP:0011109)2.00303349
40Absent septum pellucidum (HP:0001331)1.99429934
41True hermaphroditism (HP:0010459)1.98698456
42Nephronophthisis (HP:0000090)1.97231608
43Arterial tortuosity (HP:0005116)1.96767058
44Anencephaly (HP:0002323)1.94851577
45Absent frontal sinuses (HP:0002688)1.93656840
46Stage 5 chronic kidney disease (HP:0003774)1.92841641
47Congenital hepatic fibrosis (HP:0002612)1.92194291
48Anosmia (HP:0000458)1.92130528
49Anophthalmia (HP:0000528)1.90758444
50Ankyloglossia (HP:0010296)1.86998044
51Bilateral microphthalmos (HP:0007633)1.83477062
52Tarsal synostosis (HP:0008368)1.83390815
53Aplasia/Hypoplasia of the tongue (HP:0010295)1.83089809
54Recurrent otitis media (HP:0000403)1.82863857
55Bifid scrotum (HP:0000048)1.82027669
56Abnormality of the upper arm (HP:0001454)1.79179602
57Small epiphyses (HP:0010585)1.78457282
58Recurrent bronchitis (HP:0002837)1.77443968
59Bell-shaped thorax (HP:0001591)1.77107247
60Male pseudohermaphroditism (HP:0000037)1.77106072
61Epiphyseal dysplasia (HP:0002656)1.76340224
62Decreased circulating renin level (HP:0003351)1.75732334
63Aqueductal stenosis (HP:0002410)1.74405628
64Vascular tortuosity (HP:0004948)1.73911888
65Esophageal atresia (HP:0002032)1.72162461
66Synostosis involving bones of the lower limbs (HP:0009138)1.72088506
67Synostosis involving bones of the feet (HP:0009140)1.72088506
68Interstitial pulmonary disease (HP:0006530)1.72082815
69Truncus arteriosus (HP:0001660)1.71346103
70Tubulointerstitial abnormality (HP:0001969)1.70052554
71Tachypnea (HP:0002789)1.68892792
72Cheekbone underdevelopment (HP:0010669)1.68082284
73Aplasia/Hypoplasia of the spleen (HP:0010451)1.67640930
74Asplenia (HP:0001746)1.67371407
75Stridor (HP:0010307)1.66202854
76Growth hormone deficiency (HP:0000824)1.65352027
77Hyperkalemia (HP:0002153)1.65076777
78Medial flaring of the eyebrow (HP:0010747)1.64929565
79Nephropathy (HP:0000112)1.64338678
80Abnormality of the labia minora (HP:0012880)1.63997400
81Abnormal drinking behavior (HP:0030082)1.63229768
82Polydipsia (HP:0001959)1.63229768
83Tubulointerstitial nephritis (HP:0001970)1.61874687
84Renal salt wasting (HP:0000127)1.60262218
85Coronal craniosynostosis (HP:0004440)1.60164630
86Abnormality of the humerus (HP:0003063)1.59693682
87Supranuclear gaze palsy (HP:0000605)1.58523369
88Abnormality of the renal medulla (HP:0100957)1.58388935
89Sclerocornea (HP:0000647)1.58250928
90Congenital primary aphakia (HP:0007707)1.58173212
91Gait imbalance (HP:0002141)1.56808461
92Ulnar deviation of finger (HP:0009465)1.56804729
93Furrowed tongue (HP:0000221)1.56410470
94Oligodactyly (hands) (HP:0001180)1.56296478
95Oculomotor apraxia (HP:0000657)1.56167716
96Buphthalmos (HP:0000557)1.56120489
97Abnormality of the septum pellucidum (HP:0007375)1.55233042
98Difficulty running (HP:0009046)1.55033539
99Concave nail (HP:0001598)1.54138454
100Scanning speech (HP:0002168)1.54132935
101Cystic liver disease (HP:0006706)1.54072184
102Broad metatarsal (HP:0001783)1.52923275
103Recurrent sinusitis (HP:0011108)1.52221122
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.51858681
105Humeroradial synostosis (HP:0003041)1.51654096
106Synostosis involving the elbow (HP:0003938)1.51654096
107Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50565482
108Bowel incontinence (HP:0002607)1.50562365
109Hyperaldosteronism (HP:0000859)1.49857646
110Papilledema (HP:0001085)1.49704141
111Carpal synostosis (HP:0009702)1.49586307
112Abnormality of the dental root (HP:0006486)1.48792759
113Taurodontia (HP:0000679)1.48792759
114Abnormality of permanent molar morphology (HP:0011071)1.48792759
115Postaxial hand polydactyly (HP:0001162)1.48646919
116Narrow nasal bridge (HP:0000446)1.47960614
117Abnormality of midbrain morphology (HP:0002418)1.47772908
118Molar tooth sign on MRI (HP:0002419)1.47772908
119Peripheral hypomyelination (HP:0007182)1.44654386
120Overriding aorta (HP:0002623)1.42838487
121Hyperactive renin-angiotensin system (HP:0000841)1.42541855
122Abnormality of oral frenula (HP:0000190)1.42334789
123Lower limb muscle weakness (HP:0007340)1.42211913
124Atelectasis (HP:0100750)1.42165233
125Aortic aneurysm (HP:0004942)1.41922224
126Specific learning disability (HP:0001328)1.41532938
127Abnormality of chloride homeostasis (HP:0011422)1.38120376
128Nephrogenic diabetes insipidus (HP:0009806)1.35322148
129Abnormality of renin-angiotensin system (HP:0000847)1.34419631
130Short thorax (HP:0010306)1.28430767
131Median cleft lip (HP:0000161)1.27650204
132Preaxial hand polydactyly (HP:0001177)1.26629337
133Hand muscle atrophy (HP:0009130)1.25940546
134Abnormality of the distal phalanges of the toes (HP:0010182)1.24882578
135Obstructive sleep apnea (HP:0002870)1.22969292
136Glucose intolerance (HP:0000833)1.21840932
137Abnormality of the frontal sinuses (HP:0002687)1.19890111
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.19314833
139Hypokalemic alkalosis (HP:0001949)1.18900035
140Hyponatremia (HP:0002902)1.17142599
141Abnormality of molar morphology (HP:0011070)1.16769716
142Abnormality of molar (HP:0011077)1.16769716
143Short femoral neck (HP:0100864)1.13713387
144Abnormality of the dental pulp (HP:0006479)1.13002430
145Fetal akinesia sequence (HP:0001989)1.11231722
146Vaginal atresia (HP:0000148)1.09646742
147Genital tract atresia (HP:0001827)1.08374817
148Poor coordination (HP:0002370)1.08152268
149Cone-rod dystrophy (HP:0000548)1.07175506
150Flat acetabular roof (HP:0003180)1.05684107
151Decreased central vision (HP:0007663)1.05189573
152Aplasia of the musculature (HP:0100854)1.03363790
153Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.01953050
154Abnormality of monocarboxylic acid metabolism (HP:0010996)1.00885337
155Popliteal pterygium (HP:0009756)0.98151983
156Muscle fiber splitting (HP:0003555)0.98042097
157Absent rod-and cone-mediated responses on ERG (HP:0007688)0.97214172
158Self-mutilation (HP:0000742)0.94856204
159Spinal muscular atrophy (HP:0007269)0.94410622
160Spinal cord compression (HP:0002176)0.93223148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR15.54447805
2EPHB25.37192158
3EPHA25.04616670
4SIK34.87113430
5NTRK14.22562213
6BCR3.71258079
7NTRK23.57998524
8ICK2.48938205
9SMG12.44354221
10SIK12.41205848
11LMTK22.20629250
12NME12.14738360
13MAPKAPK32.08374110
14ERBB22.00150837
15TESK11.97622965
16PNCK1.92883541
17MAPK151.92158509
18STK241.85245087
19MARK11.84634348
20PRKD31.84014671
21MINK11.80256204
22ROCK21.78872779
23EIF2AK31.77139124
24TTK1.65290713
25MAP3K31.50549397
26CSK1.48872685
27PAK61.33531933
28PAK41.33032438
29TRIB31.27722651
30PDK41.24452411
31PDK31.24452411
32EPHA31.20536879
33FGFR21.19955401
34NEK61.13375007
35IRAK11.09230740
36EPHB11.07711869
37MST1R1.06064117
38PHKG11.05026141
39PHKG21.05026141
40MARK21.04160057
41TGFBR21.03819362
42FER1.00731514
43DMPK1.00600910
44TYRO30.97244139
45UHMK10.92854666
46CDK180.88314116
47MAP3K70.87570879
48KSR20.87525287
49LRRK20.87346880
50MST40.87220172
51IRAK20.85941376
52TLK10.85772220
53DDR20.85627242
54STK390.84362396
55LIMK10.84225184
56DYRK1B0.83758843
57TBK10.79963128
58PAK30.76516480
59TRPM70.75121500
60PRKCI0.73318134
61CAMK1G0.72971579
62PTK60.72426096
63ROCK10.72314881
64STK380.71648103
65RIPK40.71613468
66CDK140.64581409
67SRC0.63887749
68MAP3K90.63205657
69PTK20.63091007
70MAP3K100.62511710
71CDK150.57501290
72PRKCZ0.57187550
73EEF2K0.56966180
74ERBB30.55736606
75MATK0.55176694
76CDK50.54796282
77CSNK1G30.54147078
78FYN0.53857436
79CSNK1A1L0.52576555
80PBK0.51870662
81MET0.51808153
82MTOR0.51699121
83MAP3K120.48824990
84CDK11A0.48748772
85MAP3K20.48684928
86CAMK2G0.48346557
87EGFR0.47962168
88PAK20.46945832
89FGFR30.46265676
90PDK20.46067282
91TSSK60.45386445
92STK100.44648612
93PRKCD0.44324829
94CAMKK10.43592792
95AURKA0.42940824
96HIPK20.41853762
97BRSK10.41555412
98BRSK20.41432290
99CSNK1G20.41230581
100PDPK10.41019502
101CAMK2B0.40955445
102NTRK30.40189007
103NLK0.39643971
104PTK2B0.39399540
105LATS10.37056128
106PRKCQ0.37041403
107SGK10.37004836
108RIPK10.36633417
109CDC42BPA0.36192866
110TNIK0.34757796
111TAOK10.34472472
112GRK60.33626367
113CHUK0.32692344
114PASK0.32275686
115RPS6KB20.31919791
116DAPK20.31317268
117PRKAA20.31200352
118PRKCG0.31092435
119PKN10.30310927
120MAP2K20.30267999
121CDK190.30190648
122MAP3K40.29812665
123MAPKAPK20.29652613
124BMX0.29176417
125STK38L0.28907777
126ILK0.28587012
127STK160.27622002
128SGK2230.27193900
129SGK4940.27193900
130RPS6KA20.26778743
131CAMK2D0.26415451
132STK110.25987946
133DYRK20.25686443
134CAMK2A0.24653956
135LATS20.24045018
136FGFR10.24000030
137CSNK1G10.23486241
138PRKCE0.22745776
139MAP2K40.22373277
140DYRK1A0.21345711
141RET0.20575465
142WNK40.20481534
143AKT20.19578344
144RPS6KA10.19302496
145PRKACA0.17785800
146PRKCA0.17508573
147FGFR40.17365017
148ABL10.16930289
149MAPKAPK50.15395252
150MAP2K70.15205122
151CDK60.14935660
152PLK10.14779998
153ADRBK10.14635065
154INSRR0.13247311
155NEK90.12574783
156PRKDC0.11607213
157ZAP700.11195946
158ABL20.09390628
159PAK10.08811787

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003605.32319388
2Histidine metabolism_Homo sapiens_hsa003404.84160918
3Chemical carcinogenesis_Homo sapiens_hsa052044.56632050
4Tyrosine metabolism_Homo sapiens_hsa003504.14605046
5beta-Alanine metabolism_Homo sapiens_hsa004103.15660734
6Basal cell carcinoma_Homo sapiens_hsa052173.08153567
7Axon guidance_Homo sapiens_hsa043602.63483085
8Hedgehog signaling pathway_Homo sapiens_hsa043402.55299242
9Hippo signaling pathway_Homo sapiens_hsa043902.52222137
10Huntingtons disease_Homo sapiens_hsa050162.46143048
11Retinol metabolism_Homo sapiens_hsa008302.23954238
12Nitrogen metabolism_Homo sapiens_hsa009102.14063440
13Dorso-ventral axis formation_Homo sapiens_hsa043202.07425463
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.00981913
15Caffeine metabolism_Homo sapiens_hsa002321.96890389
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.95892546
17Vitamin B6 metabolism_Homo sapiens_hsa007501.94258786
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.94076549
19Notch signaling pathway_Homo sapiens_hsa043301.86174356
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.78528683
21Melanogenesis_Homo sapiens_hsa049161.68561284
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66621040
23Sphingolipid metabolism_Homo sapiens_hsa006001.58073405
24Linoleic acid metabolism_Homo sapiens_hsa005911.53602294
25Renal cell carcinoma_Homo sapiens_hsa052111.50838144
26Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49724216
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46607683
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46117383
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45367992
30Wnt signaling pathway_Homo sapiens_hsa043101.44627004
31Gastric acid secretion_Homo sapiens_hsa049711.34348450
32Tight junction_Homo sapiens_hsa045301.32917655
33Olfactory transduction_Homo sapiens_hsa047401.30568974
34Adherens junction_Homo sapiens_hsa045201.30445779
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.29673027
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29439673
37Fatty acid degradation_Homo sapiens_hsa000711.27463628
38Salivary secretion_Homo sapiens_hsa049701.27037250
39Estrogen signaling pathway_Homo sapiens_hsa049151.24144525
40Bladder cancer_Homo sapiens_hsa052191.21661318
41Glioma_Homo sapiens_hsa052141.18474211
42Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16221174
43ECM-receptor interaction_Homo sapiens_hsa045121.15410967
44Fatty acid biosynthesis_Homo sapiens_hsa000611.15189698
45Circadian entrainment_Homo sapiens_hsa047131.14029983
46GABAergic synapse_Homo sapiens_hsa047271.13888462
47ABC transporters_Homo sapiens_hsa020101.13505821
48Chronic myeloid leukemia_Homo sapiens_hsa052201.13215754
49Proteoglycans in cancer_Homo sapiens_hsa052051.10523433
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09792416
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06686197
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06306681
53Focal adhesion_Homo sapiens_hsa045101.05925605
54ErbB signaling pathway_Homo sapiens_hsa040121.02487291
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.97857124
56Peroxisome_Homo sapiens_hsa041460.97731614
57Synaptic vesicle cycle_Homo sapiens_hsa047210.97256300
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96008338
59Nicotine addiction_Homo sapiens_hsa050330.92059811
60Endometrial cancer_Homo sapiens_hsa052130.92008560
61Gap junction_Homo sapiens_hsa045400.91995585
62MicroRNAs in cancer_Homo sapiens_hsa052060.90653165
63Mineral absorption_Homo sapiens_hsa049780.89188832
64Arachidonic acid metabolism_Homo sapiens_hsa005900.87931896
65TGF-beta signaling pathway_Homo sapiens_hsa043500.86627948
66Pancreatic cancer_Homo sapiens_hsa052120.85574417
67Glutamatergic synapse_Homo sapiens_hsa047240.85401719
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85218940
69Renin secretion_Homo sapiens_hsa049240.83542762
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82685030
71Cocaine addiction_Homo sapiens_hsa050300.81992297
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81280555
73Amphetamine addiction_Homo sapiens_hsa050310.79726854
74Bile secretion_Homo sapiens_hsa049760.79110932
75Thyroid hormone synthesis_Homo sapiens_hsa049180.78820691
76Colorectal cancer_Homo sapiens_hsa052100.78668190
77Morphine addiction_Homo sapiens_hsa050320.78111530
78Circadian rhythm_Homo sapiens_hsa047100.77816548
79Endocytosis_Homo sapiens_hsa041440.77421674
80Starch and sucrose metabolism_Homo sapiens_hsa005000.76326291
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76225706
82Prion diseases_Homo sapiens_hsa050200.75663877
83Pathways in cancer_Homo sapiens_hsa052000.74354709
84cAMP signaling pathway_Homo sapiens_hsa040240.74126840
85Glutathione metabolism_Homo sapiens_hsa004800.73772554
86Dopaminergic synapse_Homo sapiens_hsa047280.72326446
87Insulin secretion_Homo sapiens_hsa049110.71914790
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71220211
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.70925822
90Hepatitis C_Homo sapiens_hsa051600.70214925
91Choline metabolism in cancer_Homo sapiens_hsa052310.69709864
92Long-term potentiation_Homo sapiens_hsa047200.68723597
93Oocyte meiosis_Homo sapiens_hsa041140.68268858
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.66963211
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64621605
96Viral myocarditis_Homo sapiens_hsa054160.64610622
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64503124
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64334854
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.64283569
100Ras signaling pathway_Homo sapiens_hsa040140.63976948
101N-Glycan biosynthesis_Homo sapiens_hsa005100.63857574
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.63156058
103Rap1 signaling pathway_Homo sapiens_hsa040150.63086373
104Dilated cardiomyopathy_Homo sapiens_hsa054140.63003131
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62777412
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62222605
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59679324
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57167661
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57109598
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.56487809
111Cholinergic synapse_Homo sapiens_hsa047250.56046503
112Taste transduction_Homo sapiens_hsa047420.55665100
113VEGF signaling pathway_Homo sapiens_hsa043700.55517978
114Fatty acid metabolism_Homo sapiens_hsa012120.54869817
115Alcoholism_Homo sapiens_hsa050340.54226525
116Ether lipid metabolism_Homo sapiens_hsa005650.54157692
117Oxytocin signaling pathway_Homo sapiens_hsa049210.53779549
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.53711735
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51478213
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51089624
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50941886
122Fatty acid elongation_Homo sapiens_hsa000620.49830718
123Small cell lung cancer_Homo sapiens_hsa052220.49532157
124Pancreatic secretion_Homo sapiens_hsa049720.48815612
125Collecting duct acid secretion_Homo sapiens_hsa049660.48494467
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47543734
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.47395279
128Calcium signaling pathway_Homo sapiens_hsa040200.47040178
129PPAR signaling pathway_Homo sapiens_hsa033200.45987788
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43777389
131Complement and coagulation cascades_Homo sapiens_hsa046100.39503839
132Amoebiasis_Homo sapiens_hsa051460.37636052
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32797403
134Primary bile acid biosynthesis_Homo sapiens_hsa001200.32716448
135Lysosome_Homo sapiens_hsa041420.28499239
136Hematopoietic cell lineage_Homo sapiens_hsa046400.26946554
137Arginine and proline metabolism_Homo sapiens_hsa003300.26561538
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26510740
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.24436977
140Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23067121
141Metabolic pathways_Homo sapiens_hsa011000.21377500
142Phototransduction_Homo sapiens_hsa047440.17927653
143Vibrio cholerae infection_Homo sapiens_hsa051100.17810125
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16170908
145Insulin resistance_Homo sapiens_hsa049310.16031569
146Type I diabetes mellitus_Homo sapiens_hsa049400.14950985
147Serotonergic synapse_Homo sapiens_hsa047260.14886877
148Phagosome_Homo sapiens_hsa041450.14184344
149Prostate cancer_Homo sapiens_hsa052150.13113929
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12755466
151Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12263691
152Vitamin digestion and absorption_Homo sapiens_hsa049770.11119555
153Glycerolipid metabolism_Homo sapiens_hsa005610.10425204
154Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.08277320
155Antigen processing and presentation_Homo sapiens_hsa046120.08170040
156Jak-STAT signaling pathway_Homo sapiens_hsa046300.08016418
157Cardiac muscle contraction_Homo sapiens_hsa042600.05882418
158Autoimmune thyroid disease_Homo sapiens_hsa053200.05775248
159Ovarian steroidogenesis_Homo sapiens_hsa049130.04196248
160Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.03845828

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