FOXF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: FOXF2 encodes forkhead box F2, one of many human homologues of the Drosophila melanogaster transcription factor forkhead. FOXF2 is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)5.98011078
2tooth mineralization (GO:0034505)5.14042696
3kidney mesenchyme development (GO:0072074)4.93885820
4negative regulation of homotypic cell-cell adhesion (GO:0034111)4.90292596
5dermatan sulfate biosynthetic process (GO:0030208)4.76391251
6retina vasculature morphogenesis in camera-type eye (GO:0061299)4.52013207
7atrioventricular valve morphogenesis (GO:0003181)4.46090603
8dermatan sulfate metabolic process (GO:0030205)4.45816223
9outer ear morphogenesis (GO:0042473)4.45559937
10cell proliferation involved in kidney development (GO:0072111)4.43177999
11cell proliferation involved in metanephros development (GO:0072203)4.36091469
12Notch signaling involved in heart development (GO:0061314)4.17312323
13respiratory tube development (GO:0030323)4.15205727
14mesenchyme morphogenesis (GO:0072132)4.06538941
15ventricular septum morphogenesis (GO:0060412)4.05651638
16heart trabecula formation (GO:0060347)3.98366380
17vascular endothelial growth factor signaling pathway (GO:0038084)3.96210353
18cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.93054995
19endothelium development (GO:0003158)3.83606510
20developmental pigmentation (GO:0048066)3.79639242
21response to pheromone (GO:0019236)3.74885722
22lymphangiogenesis (GO:0001946)3.72591515
23artery morphogenesis (GO:0048844)3.62206144
24pattern specification involved in kidney development (GO:0061004)3.62197499
25positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.59691092
26epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.59305237
27regulation of endothelial cell differentiation (GO:0045601)3.58132132
28protein heterotrimerization (GO:0070208)3.57255830
29heart valve morphogenesis (GO:0003179)3.54358769
30embryonic skeletal joint morphogenesis (GO:0060272)3.52144146
31trabecula formation (GO:0060343)3.52115505
32regulation of non-canonical Wnt signaling pathway (GO:2000050)3.45093596
33smooth muscle tissue development (GO:0048745)3.45004116
34dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.41871697
35glomerulus development (GO:0032835)3.41198675
36negative regulation of vascular permeability (GO:0043116)3.37416378
37endocardial cushion development (GO:0003197)3.34093524
38mesenchymal cell proliferation (GO:0010463)3.33318406
39collagen fibril organization (GO:0030199)3.30672011
40regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.28943732
41endocardial cushion morphogenesis (GO:0003203)3.28714018
42chondrocyte proliferation (GO:0035988)3.26558309
43metanephric mesenchyme development (GO:0072075)3.26470094
44G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.23606963
45muscle cell proliferation (GO:0033002)3.23500020
46regulation of apoptotic process involved in morphogenesis (GO:1902337)3.23044357
47neural crest cell development (GO:0014032)3.22904392
48cardiac septum morphogenesis (GO:0060411)3.20376591
49ventricular trabecula myocardium morphogenesis (GO:0003222)3.19428324
50negative regulation of chondrocyte differentiation (GO:0032331)3.19167527
51tonic smooth muscle contraction (GO:0014820)3.17608985
52relaxation of smooth muscle (GO:0044557)3.16511811
53negative regulation of catenin import into nucleus (GO:0035414)3.15392011
54vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.13660584
55mesenchymal cell development (GO:0014031)3.12480921
56negative regulation of axon extension involved in axon guidance (GO:0048843)3.12107977
57negative regulation of androgen receptor signaling pathway (GO:0060766)3.12071739
58embryonic forelimb morphogenesis (GO:0035115)3.11134655
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.10922939
60cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.08847975
61surfactant homeostasis (GO:0043129)3.06856188
62regulation of mesenchymal cell proliferation (GO:0010464)3.05687537
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.04178356
64extracellular matrix assembly (GO:0085029)3.03835397
65negative regulation of mast cell activation (GO:0033004)3.02653436
66vasculature development (GO:0001944)3.01021573
67peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.00285346
68ribosomal small subunit biogenesis (GO:0042274)2.99668295
69negative chemotaxis (GO:0050919)2.98888883
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.98888353
71axon extension involved in axon guidance (GO:0048846)2.98888353
72type B pancreatic cell proliferation (GO:0044342)2.98435991
73embryonic heart tube development (GO:0035050)2.98297943
74positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.98162267
75adhesion of symbiont to host cell (GO:0044650)2.98037506
76virion attachment to host cell (GO:0019062)2.98037506
77blood vessel maturation (GO:0001955)2.97916566
78cell migration involved in heart development (GO:0060973)2.97628973
79hippo signaling (GO:0035329)2.97290107
80regulation of cardioblast proliferation (GO:0003264)2.95872492
81regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95872492
82omega-hydroxylase P450 pathway (GO:0097267)2.95255182
83wound healing, spreading of epidermal cells (GO:0035313)2.95061070
84establishment of apical/basal cell polarity (GO:0035089)2.94658148
85heart valve formation (GO:0003188)2.94072510
86negative regulation of stem cell proliferation (GO:2000647)2.93886076
87regulation of glomerular filtration (GO:0003093)2.90644842
88mesenchymal-epithelial cell signaling (GO:0060638)2.90513285
89lateral sprouting from an epithelium (GO:0060601)2.89857155
90extracellular negative regulation of signal transduction (GO:1900116)2.89467741
91extracellular regulation of signal transduction (GO:1900115)2.89467741
92basement membrane organization (GO:0071711)2.89357757
93potassium ion import (GO:0010107)2.88806732
94regulation of endothelial cell chemotaxis (GO:2001026)2.88787207
95regulation of organ formation (GO:0003156)2.88669665
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.86952331
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.86952331
98positive regulation of mesenchymal cell proliferation (GO:0002053)2.86012459
99forelimb morphogenesis (GO:0035136)2.85933465
100positive regulation of catenin import into nucleus (GO:0035413)2.85096122
101cardiac muscle cell proliferation (GO:0060038)2.84267298
102diaphragm development (GO:0060539)2.83660975
103organ induction (GO:0001759)2.83293963
104head development (GO:0060322)2.82454401
105positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.82141769
106ventricular cardiac muscle cell development (GO:0055015)2.81233863
107atrial septum morphogenesis (GO:0060413)2.79617234
108ganglion development (GO:0061548)2.78483300
109maternal placenta development (GO:0001893)2.78147333
110positive regulation of smooth muscle cell migration (GO:0014911)2.77335026
111cardiac epithelial to mesenchymal transition (GO:0060317)2.75593374
112positive regulation of odontogenesis (GO:0042482)2.75172182
113mesodermal cell differentiation (GO:0048333)2.74905470
114planar cell polarity pathway involved in neural tube closure (GO:0090179)2.74827128
115glomerular filtration (GO:0003094)2.74575018
116positive regulation of vasculogenesis (GO:2001214)2.74064490
117stem cell development (GO:0048864)2.73394142
118negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.73217627
119smooth muscle cell differentiation (GO:0051145)2.72741368
120regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.72523406
121adherens junction assembly (GO:0034333)2.72474963
122lung lobe morphogenesis (GO:0060463)2.71911917
123regulation of glucocorticoid metabolic process (GO:0031943)2.70657813
124coronary vasculature morphogenesis (GO:0060977)2.69945461
125positive regulation of hormone biosynthetic process (GO:0046886)2.69246765
126negative regulation of embryonic development (GO:0045992)2.68935869
127paraxial mesoderm development (GO:0048339)2.68620560
128regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.68242949
129regulation of heart morphogenesis (GO:2000826)2.68106233
130sequestering of extracellular ligand from receptor (GO:0035581)2.67757176
131sprouting angiogenesis (GO:0002040)2.67706294
132regulation of catenin import into nucleus (GO:0035412)2.67350915
133negative regulation of cartilage development (GO:0061037)2.67242712
134retinal ganglion cell axon guidance (GO:0031290)2.66677656
135endothelial tube morphogenesis (GO:0061154)2.64014558
136morphogenesis of an endothelium (GO:0003159)2.64014558
137negative regulation of cell fate specification (GO:0009996)2.63538631
138mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.63068882
139exocrine pancreas development (GO:0031017)2.61761413
140cochlea morphogenesis (GO:0090103)2.60753328
141cell surface receptor signaling pathway involved in heart development (GO:0061311)2.58954972
142regulation of mesenchymal cell apoptotic process (GO:2001053)2.58337320
143limb bud formation (GO:0060174)2.57742682
144regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.55305004
145mesenchymal cell differentiation (GO:0048762)2.55028604
146outflow tract morphogenesis (GO:0003151)2.54581571
147embryonic cranial skeleton morphogenesis (GO:0048701)2.52069731
148chemical homeostasis within a tissue (GO:0048875)2.51446629
149regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.50466381
150patterning of blood vessels (GO:0001569)2.50416953
151bone trabecula formation (GO:0060346)2.50386668
152aorta morphogenesis (GO:0035909)2.49526607
153* embryonic camera-type eye morphogenesis (GO:0048596)2.48716855
154* epithelial to mesenchymal transition (GO:0001837)2.48316366
155wound healing, spreading of cells (GO:0044319)2.48162731
156mesonephros development (GO:0001823)2.47675606
157mesenchyme development (GO:0060485)2.46454048
158cerebral cortex radially oriented cell migration (GO:0021799)2.45714198
159artery development (GO:0060840)2.45306026
160middle ear morphogenesis (GO:0042474)2.44784590
161endoderm formation (GO:0001706)2.43688889
162positive regulation of protein kinase C signaling (GO:0090037)2.43178879
163renal filtration (GO:0097205)2.42913194
164blood vessel morphogenesis (GO:0048514)2.42117525
165positive regulation of endothelial cell differentiation (GO:0045603)2.41674476
166regulation of somitogenesis (GO:0014807)2.40297638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARG_19884340_ChIP-ChIP_MEFs_Mouse3.71312503
2* EED_16625203_ChIP-ChIP_MESCs_Mouse3.20340474
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.96528313
4GBX2_23144817_ChIP-Seq_PC3_Human2.96054635
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.87858326
6* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75725891
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.65706579
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64474002
9* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.58534618
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.52770893
11* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47301809
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.45188058
13* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.43084556
14ELK3_25401928_ChIP-Seq_HUVEC_Human2.43008291
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.39826907
16* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.39826907
17* CBX2_27304074_Chip-Seq_ESCs_Mouse2.36413023
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.34909240
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32043791
20* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30069631
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.29463174
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25223545
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.22790517
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.22731639
25* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.18282708
26* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15902626
27WT1_19549856_ChIP-ChIP_CCG9911_Human2.13195984
28CLOCK_20551151_ChIP-Seq_293T_Human2.12792546
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10455831
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10158816
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08367932
32* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07546294
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.07365694
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05449433
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.04258892
36* TP63_19390658_ChIP-ChIP_HaCaT_Human2.01068956
37LXR_22292898_ChIP-Seq_THP-1_Human1.96578940
38TP53_18474530_ChIP-ChIP_U2OS_Human1.95159453
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94560834
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94448027
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93001787
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92195370
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88285298
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.86078444
45CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.77112507
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.75768390
47* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.73495542
48* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73374869
49SMC1_22415368_ChIP-Seq_MEFs_Mouse1.70350162
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67679789
51RACK7_27058665_Chip-Seq_MCF-7_Human1.67251449
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65768083
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65656707
54SMC3_22415368_ChIP-Seq_MEFs_Mouse1.65019619
55P300_19829295_ChIP-Seq_ESCs_Human1.64299054
56* EZH2_27294783_Chip-Seq_ESCs_Mouse1.64283161
57* TP53_20018659_ChIP-ChIP_R1E_Mouse1.63390179
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63087300
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.61445267
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.59771183
61AR_21909140_ChIP-Seq_LNCAP_Human1.59232627
62* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59058060
63NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57453294
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.56392663
65EZH2_22144423_ChIP-Seq_EOC_Human1.52241802
66UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.52055481
67UBF1/2_26484160_Chip-Seq_HMECs_Human1.49924862
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.49897210
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49694574
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48830755
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47885678
72CJUN_26792858_Chip-Seq_BT549_Human1.46218545
73* RNF2_27304074_Chip-Seq_NSC_Mouse1.45431693
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.45068017
75KDM2B_26808549_Chip-Seq_K562_Human1.42249487
76SA1_22415368_ChIP-Seq_MEFs_Mouse1.41670027
77FUS_26573619_Chip-Seq_HEK293_Human1.41295980
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40932992
79IGF1R_20145208_ChIP-Seq_DFB_Human1.40917753
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40691937
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40524166
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.40334842
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.39522839
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39070008
85AR_21572438_ChIP-Seq_LNCaP_Human1.38846930
86STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.37225762
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36735059
88* RING1B_27294783_Chip-Seq_NPCs_Mouse1.35887202
89AHR_22903824_ChIP-Seq_MCF-7_Human1.32938774
90RXR_22108803_ChIP-Seq_LS180_Human1.30971513
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30468504
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30468504
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30415953
94TP53_22127205_ChIP-Seq_IMR90_Human1.30173054
95* KDM2B_26808549_Chip-Seq_JURKAT_Human1.29771566
96EWS_26573619_Chip-Seq_HEK293_Human1.29104595
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28947136
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28938609
99SMAD4_21799915_ChIP-Seq_A2780_Human1.27958724
100TP53_16413492_ChIP-PET_HCT116_Human1.27532387
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.25387253
102CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24276190
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.22684534
104* RING1B_27294783_Chip-Seq_ESCs_Mouse1.22473516
105TAF15_26573619_Chip-Seq_HEK293_Human1.22164092
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22018331
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20821364
108GATA2_21666600_ChIP-Seq_HMVEC_Human1.20065513
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.19680737
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.19670313
111VDR_22108803_ChIP-Seq_LS180_Human1.19188435
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18647541
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18457712
114KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18314062
115AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17807020
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17632127
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16225790
118CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15884482
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15101881
120E2F1_18555785_Chip-Seq_ESCs_Mouse1.14706106
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14451496
122ER_23166858_ChIP-Seq_MCF-7_Human1.11689180
123* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11644683
124* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10509847
125KDM2B_26808549_Chip-Seq_DND41_Human1.10216978
126* XRN2_22483619_ChIP-Seq_HELA_Human1.10045414
127AR_25329375_ChIP-Seq_VCAP_Human1.08081343
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07816672
129* RUNX2_22187159_ChIP-Seq_PCA_Human1.07677635
130CDX2_20551321_ChIP-Seq_CACO-2_Human1.07515192
131ESR2_21235772_ChIP-Seq_MCF-7_Human1.07257655
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06473507
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06312535
134CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06217266
135IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05071776
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03321194
137SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03245474
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02776612
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02206948
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01355877
141FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00486297
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00322685
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00162527
144SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00060447
145SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98481310
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.97794578
147OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97212518
148P53_22387025_ChIP-Seq_ESCs_Mouse0.96852756
149VDR_24787735_ChIP-Seq_THP-1_Human0.95917541
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.93960391
151ZNF263_19887448_ChIP-Seq_K562_Human0.93729157
152BRD4_25478319_ChIP-Seq_HGPS_Human0.93473115
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93277782
154TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93035159
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.92509096
156SMAD3_21741376_ChIP-Seq_HESCs_Human0.92356895
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92189124
158PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92004727
159JUN_21703547_ChIP-Seq_K562_Human0.91763958
160TCF4_18268006_ChIP-ChIP_LS174T_Human0.91404031
161YAP1_20516196_ChIP-Seq_MESCs_Mouse0.90914546
162KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90185587
163KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90185587
164KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90185587
165* MYC_27129775_Chip-Seq_CORNEA_Mouse0.88806216

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.14410625
2MP0001879_abnormal_lymphatic_vessel3.73459705
3MP0005171_absent_coat_pigmentation3.72206739
4MP0001188_hyperpigmentation3.37455002
5MP0003122_maternal_imprinting3.12542266
6MP0009379_abnormal_foot_pigmentation3.12206517
7MP0004272_abnormal_basement_membrane3.09241672
8MP0002938_white_spotting3.06214449
9MP0003385_abnormal_body_wall2.92784373
10MP0008438_abnormal_cutaneous_collagen2.79957766
11MP0005623_abnormal_meninges_morphology2.65123935
12MP0003279_aneurysm2.58891221
13MP0003941_abnormal_skin_development2.52964775
14MP0003283_abnormal_digestive_organ2.51002451
15MP0005503_abnormal_tendon_morphology2.41353573
16MP0000566_synostosis2.39429614
17MP0010368_abnormal_lymphatic_system2.30107709
18MP0002249_abnormal_larynx_morphology2.29427849
19MP0009250_abnormal_appendicular_skeleto2.18546566
20MP0005167_abnormal_blood-brain_barrier2.10361596
21MP0000049_abnormal_middle_ear2.06529962
22MP0000534_abnormal_ureter_morphology1.89616689
23MP0002009_preneoplasia1.88965988
24MP0001958_emphysema1.83738877
25MP0005367_renal/urinary_system_phenotyp1.83662456
26MP0000516_abnormal_urinary_system1.83662456
27MP0001346_abnormal_lacrimal_gland1.78707717
28MP0010030_abnormal_orbit_morphology1.77667016
29MP0004147_increased_porphyrin_level1.76837818
30MP0009278_abnormal_bone_marrow1.71654420
31MP0003828_pulmonary_edema1.70222272
32MP0009384_cardiac_valve_regurgitation1.69583963
33MP0009697_abnormal_copulation1.60005592
34MP0002102_abnormal_ear_morphology1.59647672
35MP0000767_abnormal_smooth_muscle1.59243716
36MP0004858_abnormal_nervous_system1.56447032
37MP0003942_abnormal_urinary_system1.54515872
38MP0000372_irregular_coat_pigmentation1.52193348
39MP0001542_abnormal_bone_strength1.45963566
40MP0005023_abnormal_wound_healing1.45007125
41MP0005508_abnormal_skeleton_morphology1.40917617
42MP0005248_abnormal_Harderian_gland1.38549565
43MP0005084_abnormal_gallbladder_morpholo1.37751961
44MP0002877_abnormal_melanocyte_morpholog1.37102868
45MP0002233_abnormal_nose_morphology1.35999614
46MP0000537_abnormal_urethra_morphology1.35142065
47MP0003566_abnormal_cell_adhesion1.33954126
48MP0002177_abnormal_outer_ear1.32841650
49MP0005409_darkened_coat_color1.30038352
50MP0006292_abnormal_olfactory_placode1.28897082
51MP0003937_abnormal_limbs/digits/tail_de1.28408310
52MP0000462_abnormal_digestive_system1.25928188
53MP0002932_abnormal_joint_morphology1.25011215
54* MP0002116_abnormal_craniofacial_bone1.22736135
55MP0002234_abnormal_pharynx_morphology1.21498974
56MP0002060_abnormal_skin_morphology1.19047283
57* MP0003755_abnormal_palate_morphology1.18150292
58MP0000432_abnormal_head_morphology1.16978566
59* MP0000762_abnormal_tongue_morphology1.16394242
60* MP0003935_abnormal_craniofacial_develop1.14170848
61MP0002160_abnormal_reproductive_system1.13311096
62MP0005275_abnormal_skin_tensile1.12542487
63MP0000538_abnormal_urinary_bladder1.10395021
64MP0006054_spinal_hemorrhage1.09917629
65MP0000013_abnormal_adipose_tissue1.09396228
66MP0005595_abnormal_vascular_smooth1.04455422
67MP0002277_abnormal_respiratory_mucosa1.04252371
68MP0005257_abnormal_intraocular_pressure1.04132200
69MP0002127_abnormal_cardiovascular_syste1.02292688
70MP0002295_abnormal_pulmonary_circulatio1.02015166
71MP0001299_abnormal_eye_distance/1.01782139
72MP0000163_abnormal_cartilage_morphology1.00701273
73MP0002098_abnormal_vibrissa_morphology1.00669606
74MP0003136_yellow_coat_color0.99750692
75MP0002113_abnormal_skeleton_development0.99211840
76MP0000733_abnormal_muscle_development0.97509599
77MP0006138_congestive_heart_failure0.97132303
78MP0000681_abnormal_thyroid_gland0.96731867
79MP0002109_abnormal_limb_morphology0.96256266
80MP0002896_abnormal_bone_mineralization0.93990151
81MP0002282_abnormal_trachea_morphology0.93294930
82MP0002933_joint_inflammation0.92985453
83MP0005187_abnormal_penis_morphology0.92619993
84MP0002115_abnormal_skeleton_extremities0.92542846
85MP0001286_abnormal_eye_development0.92463428
86MP0000015_abnormal_ear_pigmentation0.91749518
87MP0002114_abnormal_axial_skeleton0.90073041
88MP0000343_altered_response_to0.89878450
89MP0004484_altered_response_of0.89448845
90MP0003121_genomic_imprinting0.88514506
91MP0004782_abnormal_surfactant_physiolog0.87922150
92MP0003938_abnormal_ear_development0.87285634
93MP0001243_abnormal_dermal_layer0.87028060
94MP0002108_abnormal_muscle_morphology0.86757618
95MP0003091_abnormal_cell_migration0.86515622
96MP0000678_abnormal_parathyroid_gland0.86393085
97MP0000428_abnormal_craniofacial_morphol0.85950688
98MP0002128_abnormal_blood_circulation0.85915980
99MP0002697_abnormal_eye_size0.85559413
100MP0003943_abnormal_hepatobiliary_system0.84768224
101MP0009053_abnormal_anal_canal0.83703147
102MP0001614_abnormal_blood_vessel0.83057569
103MP0002925_abnormal_cardiovascular_devel0.82877681
104MP0000003_abnormal_adipose_tissue0.82540804
105MP0003115_abnormal_respiratory_system0.81869386
106MP0002133_abnormal_respiratory_system0.81510217
107MP0005388_respiratory_system_phenotype0.81510217
108MP0001293_anophthalmia0.80305278
109MP0003878_abnormal_ear_physiology0.80007680
110MP0005377_hearing/vestibular/ear_phenot0.80007680
111MP0003724_increased_susceptibility_to0.79869255
112MP0002111_abnormal_tail_morphology0.79664320
113MP0002092_abnormal_eye_morphology0.75727188
114MP0005164_abnormal_response_to0.75711665
115MP0002998_abnormal_bone_remodeling0.75513070
116MP0001664_abnormal_digestion0.75501924
117MP0000751_myopathy0.75261623
118MP0003448_altered_tumor_morphology0.75063862
119MP0003119_abnormal_digestive_system0.73932756
120MP0004883_abnormal_blood_vessel0.73687627
121MP0010352_gastrointestinal_tract_polyps0.73165277
122MP0008995_early_reproductive_senescence0.72493933
123MP0001175_abnormal_lung_morphology0.71775260
124MP0005197_abnormal_uvea_morphology0.70616003
125MP0000613_abnormal_salivary_gland0.70246175
126MP0002163_abnormal_gland_morphology0.70115913
127MP0000759_abnormal_skeletal_muscle0.68985205
128MP0000026_abnormal_inner_ear0.68117738
129MP0001915_intracranial_hemorrhage0.67477369
130MP0002396_abnormal_hematopoietic_system0.67182220
131MP0005390_skeleton_phenotype0.64306609
132MP0008932_abnormal_embryonic_tissue0.63408117
133MP0005076_abnormal_cell_differentiation0.63392037
134MP0002085_abnormal_embryonic_tissue0.61808359
135MP0005165_increased_susceptibility_to0.59466037
136MP0003950_abnormal_plasma_membrane0.57839386
137MP0005330_cardiomyopathy0.57286242
138MP0010307_abnormal_tumor_latency0.56906867

Predicted human phenotypes

RankGene SetZ-score
1Follicular hyperkeratosis (HP:0007502)4.86597233
2Aortic aneurysm (HP:0004942)4.34908662
3Abnormal umbilical cord blood vessels (HP:0011403)4.08788965
4Single umbilical artery (HP:0001195)4.08788965
5Abnormality of the fetal cardiovascular system (HP:0010948)4.08788965
6Asymmetry of the thorax (HP:0001555)3.91082394
7Axonal loss (HP:0003447)3.83016839
8Ankle contracture (HP:0006466)3.57430571
9Premature rupture of membranes (HP:0001788)3.23199132
10Abnormality of the phalanges of the hallux (HP:0010057)3.22747010
11Nuclear cataract (HP:0100018)3.19909674
12Midline defect of the nose (HP:0004122)3.05312446
13Absent eyebrow (HP:0002223)3.04575361
14Type 1 muscle fiber predominance (HP:0003803)3.02971531
15Vertebral compression fractures (HP:0002953)2.94855464
16Wormian bones (HP:0002645)2.92327764
17Abnormality of the parietal bone (HP:0002696)2.87659596
18Abnormality of the umbilical cord (HP:0010881)2.87635088
19Abnormality of the anterior chamber (HP:0000593)2.82967556
20Soft skin (HP:0000977)2.81556638
21Broad metatarsal (HP:0001783)2.81373391
22Bladder diverticulum (HP:0000015)2.76672452
23Genu recurvatum (HP:0002816)2.74824211
24Short 4th metacarpal (HP:0010044)2.71448316
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71448316
26Short hallux (HP:0010109)2.70249617
27Slender build (HP:0001533)2.69602052
28Morphological abnormality of the middle ear (HP:0008609)2.66103509
29Deviation of the hallux (HP:0010051)2.65838400
30Abnormality of the right ventricle (HP:0001707)2.64300424
31Ulnar bowing (HP:0003031)2.62511821
32Mesomelia (HP:0003027)2.59430896
33Aplasia cutis congenita (HP:0001057)2.59047860
34Hallux valgus (HP:0001822)2.58234563
35Congenital sensorineural hearing impairment (HP:0008527)2.46860069
36Blue sclerae (HP:0000592)2.46442891
37Overgrowth (HP:0001548)2.46128123
38Shallow orbits (HP:0000586)2.44764438
39Tetraparesis (HP:0002273)2.44395192
40Broad distal phalanx of finger (HP:0009836)2.42785407
41Cutaneous finger syndactyly (HP:0010554)2.42766006
42Partial duplication of the phalanx of hand (HP:0009999)2.41561682
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39204812
44Cervical subluxation (HP:0003308)2.38892948
45Absent eyelashes (HP:0000561)2.37521468
46Bowel diverticulosis (HP:0005222)2.35420053
47Preaxial foot polydactyly (HP:0001841)2.34639674
48Nonimmune hydrops fetalis (HP:0001790)2.34634630
49Dilatation of the ascending aorta (HP:0005111)2.33958592
50Trigonocephaly (HP:0000243)2.33466921
51Rectal prolapse (HP:0002035)2.32788700
52Elbow flexion contracture (HP:0002987)2.32494450
53Cerebral aneurysm (HP:0004944)2.28103330
54Short middle phalanx of the 5th finger (HP:0004220)2.26204657
55Abnormal ventriculo-arterial connection (HP:0011563)2.24950421
56Transposition of the great arteries (HP:0001669)2.24950421
57Abnormal connection of the cardiac segments (HP:0011545)2.24950421
58Hypoplasia of the iris (HP:0007676)2.24781293
59White forelock (HP:0002211)2.24641160
60Aortic dissection (HP:0002647)2.21966433
61Achilles tendon contracture (HP:0001771)2.20258185
62Aplasia/Hypoplasia of the hallux (HP:0008362)2.19185207
63Broad toe (HP:0001837)2.18640884
64Ectopia lentis (HP:0001083)2.17449958
65Patchy hypopigmentation of hair (HP:0011365)2.16845681
66Bone cyst (HP:0012062)2.12566140
67Chin dimple (HP:0010751)2.10178422
68Upper limb muscle weakness (HP:0003484)2.08989025
69Abnormality of the middle phalanges of the toes (HP:0010183)2.08683749
70Abnormality of the distal phalanges of the toes (HP:0010182)2.07143788
71Aplasia of the phalanges of the hand (HP:0009802)2.06997567
72Aplasia involving bones of the extremities (HP:0009825)2.06997567
73Aplasia involving bones of the upper limbs (HP:0009823)2.06997567
74Protruding ear (HP:0000411)2.06972827
75Bowing of the arm (HP:0006488)2.06510748
76Bowed forearm bones (HP:0003956)2.06510748
77Myelomeningocele (HP:0002475)2.06253065
78Biconcave vertebral bodies (HP:0004586)2.04584808
79Hypoventilation (HP:0002791)2.04359034
80Cutaneous syndactyly (HP:0012725)2.03748436
81Mitral valve prolapse (HP:0001634)2.02709263
82Abnormality of the 4th metacarpal (HP:0010012)2.02202410
83Narrow nasal bridge (HP:0000446)2.01655811
84Spinal cord lesions (HP:0100561)2.00697524
85Syringomyelia (HP:0003396)2.00697524
86Long toe (HP:0010511)2.00158545
87Joint laxity (HP:0001388)1.99974125
88Absent hair (HP:0002298)1.99384993
89Turricephaly (HP:0000262)1.97771283
90Arterial tortuosity (HP:0005116)1.97643403
91Abnormality of incisor morphology (HP:0011063)1.97250658
92Abnormality of the nasolacrimal system (HP:0000614)1.96757669
93Neonatal short-limb short stature (HP:0008921)1.96595005
94Broad hallux (HP:0010055)1.95651047
95Pulmonary artery stenosis (HP:0004415)1.95579117
96Protrusio acetabuli (HP:0003179)1.95444321
97Aortic regurgitation (HP:0001659)1.93955342
98Wide anterior fontanel (HP:0000260)1.93645748
99Bell-shaped thorax (HP:0001591)1.93461515
100Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93374227
101Hypoplastic left heart (HP:0004383)1.93370635
102Mitral stenosis (HP:0001718)1.92265686
103Vascular tortuosity (HP:0004948)1.91863580
104Septo-optic dysplasia (HP:0100842)1.90643313
105Deformed tarsal bones (HP:0008119)1.89718055
106Aortic valve stenosis (HP:0001650)1.88345312
107Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.88095752
108Cardiovascular calcification (HP:0011915)1.88045461
109Hematochezia (HP:0002573)1.87699942
110Radial bowing (HP:0002986)1.86882374
111Onycholysis (HP:0001806)1.86743104
112Delayed cranial suture closure (HP:0000270)1.86643880
113Buphthalmos (HP:0000557)1.86285934
114Increased variability in muscle fiber diameter (HP:0003557)1.86021058
115Atrophic scars (HP:0001075)1.85976081
116Mitral regurgitation (HP:0001653)1.85871067
117Mildly elevated creatine phosphokinase (HP:0008180)1.85783071
118Abnormality of the Achilles tendon (HP:0005109)1.85139076
119Short nail (HP:0001799)1.82064779
120Heterochromia iridis (HP:0001100)1.81968922
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.81678885
122Camptodactyly of toe (HP:0001836)1.81136283
123Alopecia of scalp (HP:0002293)1.80768453
124Increased corneal curvature (HP:0100692)1.80452120
125Keratoconus (HP:0000563)1.80452120
126Aneurysm (HP:0002617)1.80078706
127Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79666626
128Sparse lateral eyebrow (HP:0005338)1.78573410
129Absent hand (HP:0004050)1.78221192
130Emphysema (HP:0002097)1.77844850
131Spondylolisthesis (HP:0003302)1.77707195
132Hypoplastic heart (HP:0001961)1.77050879
133Gingival overgrowth (HP:0000212)1.76962956
134Flared iliac wings (HP:0002869)1.76403240
135Abnormality of dentin (HP:0010299)1.76131902
136Recurrent corneal erosions (HP:0000495)1.75212527
137Abnormality of the nasal septum (HP:0000419)1.74343507
138Long nose (HP:0003189)1.74249608
139Abnormality of the phalanges of the 5th finger (HP:0004213)1.73226930
140Thickened helices (HP:0000391)1.72620969
141Congenital, generalized hypertrichosis (HP:0004540)1.72096266
142Spontaneous hematomas (HP:0007420)1.70363767
143Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.70301220
144Long foot (HP:0001833)1.68908880
145Short clavicles (HP:0000894)1.68785358
146Renal duplication (HP:0000075)1.68698232
147Abnormality of the incisor (HP:0000676)1.68242826
148Hydroureter (HP:0000072)1.67785168
149Increased number of teeth (HP:0011069)1.67717628
150Supernumerary ribs (HP:0005815)1.67123403
151Spinal rigidity (HP:0003306)1.66696265
152Abnormal number of incisors (HP:0011064)1.65739055
153Hyperextensible skin (HP:0000974)1.65588380
154Craniofacial hyperostosis (HP:0004493)1.65142079
155Corneal dystrophy (HP:0001131)1.64512524
156Prominent supraorbital ridges (HP:0000336)1.64225768
157Palpebral edema (HP:0100540)1.63271853
158Pulmonary hypertension (HP:0002092)1.61168265
159Accelerated skeletal maturation (HP:0005616)1.58602936
160Aplasia/Hypoplasia of the clavicles (HP:0006710)1.58535551
161Abnormality of dental color (HP:0011073)1.58270647
162Fragile skin (HP:0001030)1.57450004
163Abnormality of the 2nd finger (HP:0004100)1.56288304
164Renal dysplasia (HP:0000110)1.55291035
165Conical tooth (HP:0000698)1.55122662
166Coronal craniosynostosis (HP:0004440)1.54746760
167Porencephaly (HP:0002132)1.54278948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.50645334
2MAPK153.94414766
3EPHB23.59206533
4CASK3.44354939
5CDK122.98032974
6KDR2.76802993
7SIK32.68157473
8PNCK2.58194938
9TNIK2.43327278
10DDR22.35094135
11EPHA32.30541492
12ICK2.25537434
13NUAK12.17732356
14ABL22.13969103
15ERN12.07894710
16PDGFRA2.04930560
17MKNK22.03173893
18FRK2.02903528
19AKT31.97829279
20TRIB31.96946031
21GRK11.96401674
22CAMK1G1.95301006
23FGFR21.94064351
24CDK81.89994532
25PRPF4B1.85202164
26ILK1.85100362
27NLK1.84336013
28PTK21.84111303
29ZAK1.83408252
30CLK11.79213913
31IRAK21.78408213
32WEE11.76165239
33MAP3K101.60260517
34RIPK11.51008137
35INSRR1.50182335
36LATS11.49680932
37MAP3K141.49559446
38ADRBK21.45976090
39PTK2B1.41390846
40BMPR1B1.38341284
41SIK21.33862798
42GRK51.30741099
43TESK11.29444228
44CAMK1D1.28465883
45MKNK11.28177601
46YES11.27498266
47STK41.24463513
48TSSK61.22262462
49NME21.16568758
50TGFBR21.13961105
51TEC1.12919137
52NTRK11.12675428
53ERBB31.10606339
54PDK21.09087821
55MYLK1.09060933
56MAPKAPK31.07860793
57SMG11.06400214
58GSK3A1.05696811
59MAPK71.01321435
60MAPK131.00310450
61KIT0.99744480
62GRK70.99606552
63LIMK10.99020131
64MET0.98577867
65MAPKAPK50.96464224
66MTOR0.95399076
67FER0.94742707
68PRKCE0.94279677
69PLK20.93695898
70PBK0.92845749
71ADRBK10.91293992
72ERBB40.90975930
73ROCK10.88979544
74MAP2K70.87719955
75MAP3K120.87152252
76BLK0.85738421
77DMPK0.83549967
78AKT20.82941326
79CDK30.81188541
80EIF2AK20.80993799
81GRK60.80901681
82PDGFRB0.80782094
83PAK20.80291110
84EEF2K0.78892722
85NEK20.78023702
86TGFBR10.77474814
87SIK10.76950729
88VRK10.76521501
89PRKD30.76184616
90RPS6KL10.75443979
91RPS6KC10.75443979
92IRAK40.74171398
93PRKAA20.72302217
94RAF10.72034228
95PAK40.71849827
96PIK3CG0.71780056
97STK30.71712031
98NEK90.71699109
99MAP3K30.70804919
100TRPM70.70607302
101AURKA0.70492078
102RPS6KA20.70405194
103ROCK20.70244909
104DAPK30.68357126
105TTN0.67503720
106ITK0.66932634
107PRKG20.65558925
108MOS0.65460284
109ARAF0.65317763
110RPS6KA60.64202135
111CDK70.63626847
112MARK30.62748351
113PTK60.62471911
114CAMK10.62220453
115TLK10.61799438
116MARK20.61000010
117EPHA40.58996123
118LATS20.56317528
119BCR0.54830662
120STK380.54397174
121PRKD10.53847732
122MAP2K30.53315722
123IGF1R0.53313577
124BUB10.52713999
125DYRK30.52537619
126FGR0.52289365
127VRK20.51603629
128CAMK2G0.51473277
129INSR0.49921745
130PKN20.49363666
131NEK60.48208183
132BRAF0.47756325
133TAOK20.46777134
134WNK10.44668696
135CDK90.44271745
136SRC0.43590889
137RET0.42128992
138STK390.40875051
139TBK10.40488069
140EPHA20.39621586
141SGK20.39303094
142PRKG10.38639784
143CAMK40.38525763
144PAK30.36985769
145KSR20.35804794
146MELK0.35382476
147CHEK20.35048147
148IRAK30.34918900
149PRKCH0.34553934
150HIPK20.34503825
151CDC42BPA0.33833502
152NTRK30.33660405
153MAPK120.33601070
154PRKD20.33468866
155SRPK10.33117058
156ABL10.31180791
157NTRK20.30667446
158BRD40.30529645
159PRKCG0.30226757
160CCNB10.29111744
161MAP2K20.28795000
162BMX0.28188465
163LRRK20.27612114
164PIK3CA0.26428209
165PIM20.26086344
166CAMK2A0.26084875
167IRAK10.26069171

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.96884904
2Folate biosynthesis_Homo sapiens_hsa007903.28638294
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.62402296
4Ribosome_Homo sapiens_hsa030102.46685250
5ECM-receptor interaction_Homo sapiens_hsa045122.46415046
6Basal cell carcinoma_Homo sapiens_hsa052172.37088785
7Adherens junction_Homo sapiens_hsa045202.12659513
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.02488548
9Hedgehog signaling pathway_Homo sapiens_hsa043401.90465812
10Focal adhesion_Homo sapiens_hsa045101.80928394
11Hippo signaling pathway_Homo sapiens_hsa043901.78663317
12Prion diseases_Homo sapiens_hsa050201.76128850
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.72657102
14Bladder cancer_Homo sapiens_hsa052191.70052065
15Axon guidance_Homo sapiens_hsa043601.64637972
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58405899
17Mineral absorption_Homo sapiens_hsa049781.54446319
18Wnt signaling pathway_Homo sapiens_hsa043101.54436986
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47840309
20TGF-beta signaling pathway_Homo sapiens_hsa043501.41879875
21Notch signaling pathway_Homo sapiens_hsa043301.38788643
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.36445514
23Morphine addiction_Homo sapiens_hsa050321.36173541
24African trypanosomiasis_Homo sapiens_hsa051431.35442611
25PI3K-Akt signaling pathway_Homo sapiens_hsa041511.35164121
26Protein digestion and absorption_Homo sapiens_hsa049741.34893926
27Melanoma_Homo sapiens_hsa052181.33462691
28Rap1 signaling pathway_Homo sapiens_hsa040151.32658541
29Rheumatoid arthritis_Homo sapiens_hsa053231.32600839
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32465815
31Small cell lung cancer_Homo sapiens_hsa052221.31686563
32MicroRNAs in cancer_Homo sapiens_hsa052061.30808493
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27931856
34Malaria_Homo sapiens_hsa051441.27181839
35Pathways in cancer_Homo sapiens_hsa052001.24701627
36Proteoglycans in cancer_Homo sapiens_hsa052051.20812340
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20455257
38Amoebiasis_Homo sapiens_hsa051461.20243246
39Prostate cancer_Homo sapiens_hsa052151.18611280
40Ras signaling pathway_Homo sapiens_hsa040141.17509813
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17495028
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.17477419
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17307034
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.17267800
45Melanogenesis_Homo sapiens_hsa049161.13876631
46Estrogen signaling pathway_Homo sapiens_hsa049151.11580987
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.11252578
48GABAergic synapse_Homo sapiens_hsa047271.11215182
49Serotonergic synapse_Homo sapiens_hsa047261.10390031
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09375733
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07121723
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06956942
53Sphingolipid metabolism_Homo sapiens_hsa006001.05658293
54p53 signaling pathway_Homo sapiens_hsa041151.04225674
55Nicotine addiction_Homo sapiens_hsa050331.03661317
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.03512957
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02985386
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02942449
59Tight junction_Homo sapiens_hsa045301.02823785
60Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00714610
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98784492
62Vibrio cholerae infection_Homo sapiens_hsa051100.98358070
63Circadian entrainment_Homo sapiens_hsa047130.98019805
64Glutamatergic synapse_Homo sapiens_hsa047240.96993006
65Dilated cardiomyopathy_Homo sapiens_hsa054140.96624215
66Dorso-ventral axis formation_Homo sapiens_hsa043200.96204729
67Ovarian steroidogenesis_Homo sapiens_hsa049130.95763446
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.93281650
69Fanconi anemia pathway_Homo sapiens_hsa034600.91335432
70Sulfur metabolism_Homo sapiens_hsa009200.87041292
71Calcium signaling pathway_Homo sapiens_hsa040200.86017241
72Cocaine addiction_Homo sapiens_hsa050300.84717404
73Hematopoietic cell lineage_Homo sapiens_hsa046400.83712884
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82834419
75One carbon pool by folate_Homo sapiens_hsa006700.82810800
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.82495837
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.79927453
78Cholinergic synapse_Homo sapiens_hsa047250.79830194
79HTLV-I infection_Homo sapiens_hsa051660.78958119
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78544317
81Glioma_Homo sapiens_hsa052140.78342708
82Phagosome_Homo sapiens_hsa041450.78079526
83Long-term depression_Homo sapiens_hsa047300.76143375
84Gap junction_Homo sapiens_hsa045400.76121821
85cAMP signaling pathway_Homo sapiens_hsa040240.75032426
86Graft-versus-host disease_Homo sapiens_hsa053320.74933248
87TNF signaling pathway_Homo sapiens_hsa046680.73302851
88N-Glycan biosynthesis_Homo sapiens_hsa005100.72455950
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72244444
90Salivary secretion_Homo sapiens_hsa049700.71933311
91Chronic myeloid leukemia_Homo sapiens_hsa052200.71564350
92Renal cell carcinoma_Homo sapiens_hsa052110.71286021
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.71086771
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70535632
95Renin secretion_Homo sapiens_hsa049240.70327408
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68416868
97Colorectal cancer_Homo sapiens_hsa052100.67946880
98Viral myocarditis_Homo sapiens_hsa054160.67241518
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66365173
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66046154
101Galactose metabolism_Homo sapiens_hsa000520.65657098
102Autoimmune thyroid disease_Homo sapiens_hsa053200.64664955
103Chemokine signaling pathway_Homo sapiens_hsa040620.64489522
104Taste transduction_Homo sapiens_hsa047420.63728218
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.63458796
106GnRH signaling pathway_Homo sapiens_hsa049120.62149140
107Platelet activation_Homo sapiens_hsa046110.61753918
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61119822
109MAPK signaling pathway_Homo sapiens_hsa040100.58982634
110Leishmaniasis_Homo sapiens_hsa051400.58252935
111Choline metabolism in cancer_Homo sapiens_hsa052310.58114334
112Huntingtons disease_Homo sapiens_hsa050160.58085640
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.57107124
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55570360
115Salmonella infection_Homo sapiens_hsa051320.55468577
116HIF-1 signaling pathway_Homo sapiens_hsa040660.55367286
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54973092
118Pertussis_Homo sapiens_hsa051330.54660057
119Oxytocin signaling pathway_Homo sapiens_hsa049210.54070111
120Allograft rejection_Homo sapiens_hsa053300.53877413
121Complement and coagulation cascades_Homo sapiens_hsa046100.53364344
122Endometrial cancer_Homo sapiens_hsa052130.53288808
123Toxoplasmosis_Homo sapiens_hsa051450.53202654
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52006222
125Hepatitis B_Homo sapiens_hsa051610.52005810
126Insulin secretion_Homo sapiens_hsa049110.51732102
127FoxO signaling pathway_Homo sapiens_hsa040680.51460818
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51165094
129Alzheimers disease_Homo sapiens_hsa050100.50310206
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50146830
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49717554
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.47679043
133Parkinsons disease_Homo sapiens_hsa050120.46064648
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45396028
135Thyroid hormone synthesis_Homo sapiens_hsa049180.44522024
136Renin-angiotensin system_Homo sapiens_hsa046140.42265841
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40035696
138Apoptosis_Homo sapiens_hsa042100.39422338
139Bile secretion_Homo sapiens_hsa049760.39161418
140Cell cycle_Homo sapiens_hsa041100.38893230
141Purine metabolism_Homo sapiens_hsa002300.37912125
142Endocytosis_Homo sapiens_hsa041440.35062346
143Glutathione metabolism_Homo sapiens_hsa004800.31989934
144Cardiac muscle contraction_Homo sapiens_hsa042600.30823281
145Oxidative phosphorylation_Homo sapiens_hsa001900.30007780
146Other glycan degradation_Homo sapiens_hsa005110.29825947
147Vitamin digestion and absorption_Homo sapiens_hsa049770.28319244
148Pancreatic cancer_Homo sapiens_hsa052120.27322200
149ErbB signaling pathway_Homo sapiens_hsa040120.25887440

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