FOXE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muscle activity (GO:0014850)9.71342148
2visual perception (GO:0007601)8.40149677
3sensory perception of light stimulus (GO:0050953)8.30293703
4cytolysis (GO:0019835)7.72921849
5histone H3-K9 demethylation (GO:0033169)7.52560119
6protein refolding (GO:0042026)7.36689971
7muscle cell cellular homeostasis (GO:0046716)7.17110569
8regulation of protein sumoylation (GO:0033233)6.51911771
9cellular response to osmotic stress (GO:0071470)6.51599622
10bile acid and bile salt transport (GO:0015721)6.46813276
11negative regulation of inclusion body assembly (GO:0090084)6.30209409
12* camera-type eye development (GO:0043010)5.99589254
13nuclear pore complex assembly (GO:0051292)5.71988513
14myofibril assembly (GO:0030239)5.71691453
15DNA replication checkpoint (GO:0000076)5.55167380
16nuclear pore organization (GO:0006999)5.54036870
17mitotic chromosome condensation (GO:0007076)5.51870949
18spliceosomal tri-snRNP complex assembly (GO:0000244)5.42978796
19maturation of SSU-rRNA (GO:0030490)5.23750238
20mitotic sister chromatid cohesion (GO:0007064)5.09596287
21DNA strand elongation involved in DNA replication (GO:0006271)5.07236777
22lung epithelium development (GO:0060428)4.98266539
23negative regulation of RNA splicing (GO:0033119)4.96124257
24DNA strand elongation (GO:0022616)4.89879889
25* eye development (GO:0001654)4.87821105
26histone H2B ubiquitination (GO:0033523)4.82786872
27positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.76342547
28negative regulation of mRNA metabolic process (GO:1903312)4.71019300
29response to salt stress (GO:0009651)4.61801475
30mitotic sister chromatid segregation (GO:0000070)4.52124102
31regulation of translational fidelity (GO:0006450)4.48846717
32DNA replication initiation (GO:0006270)4.39263857
33intra-S DNA damage checkpoint (GO:0031573)4.34260434
34sarcomere organization (GO:0045214)4.33867071
35negative regulation of homotypic cell-cell adhesion (GO:0034111)4.33363506
36telomere maintenance via semi-conservative replication (GO:0032201)4.32592759
37pore complex assembly (GO:0046931)4.26288274
38insulin-like growth factor receptor signaling pathway (GO:0048009)4.26230585
39dosage compensation (GO:0007549)4.25093020
40sister chromatid segregation (GO:0000819)4.22565509
41chromosome condensation (GO:0030261)4.13783317
42formation of translation preinitiation complex (GO:0001731)4.12988954
43DNA duplex unwinding (GO:0032508)4.02208581
44lens development in camera-type eye (GO:0002088)35.1792014
45DNA topological change (GO:0006265)3.93543459
46folic acid-containing compound biosynthetic process (GO:0009396)3.91456221
47regulation of inclusion body assembly (GO:0090083)3.91045983
48lung-associated mesenchyme development (GO:0060484)3.90824381
49regulation of myoblast differentiation (GO:0045661)3.86354995
50RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.85070220
51mRNA splicing, via spliceosome (GO:0000398)3.85070220
52DNA geometric change (GO:0032392)3.84946748
53sensory perception (GO:0007600)3.84301877
54DNA conformation change (GO:0071103)3.83779451
55RNA splicing, via transesterification reactions (GO:0000375)3.83531645
56termination of RNA polymerase II transcription (GO:0006369)3.81904776
57DNA packaging (GO:0006323)3.79372501
58rRNA catabolic process (GO:0016075)3.74609918
59* sensory organ development (GO:0007423)3.72950498
60positive regulation of dendritic spine morphogenesis (GO:0061003)3.72576329
61ribosome assembly (GO:0042255)3.71602376
62regulation of DNA endoreduplication (GO:0032875)3.67968790
63protein complex localization (GO:0031503)3.67482319
64telomere maintenance via recombination (GO:0000722)3.63882882
65protein homotrimerization (GO:0070207)3.63231743
66regulation of RNA export from nucleus (GO:0046831)3.60516009
67DNA strand renaturation (GO:0000733)3.59011342
68viral mRNA export from host cell nucleus (GO:0046784)3.57527004
69spliceosomal snRNP assembly (GO:0000387)3.56060372
70non-recombinational repair (GO:0000726)3.52837061
71double-strand break repair via nonhomologous end joining (GO:0006303)3.52837061
72dopaminergic neuron differentiation (GO:0071542)3.52600984
73mRNA export from nucleus (GO:0006406)3.45988729
74mRNA splice site selection (GO:0006376)3.44603077
75peripheral nervous system neuron development (GO:0048935)3.39958999
76establishment of integrated proviral latency (GO:0075713)3.37018020
77cardiovascular system development (GO:0072358)3.35260282
78peptidyl-arginine omega-N-methylation (GO:0035247)3.34620694
79DNA synthesis involved in DNA repair (GO:0000731)3.34073261
80positive regulation of RNA splicing (GO:0033120)3.33560436
81nucleotide-excision repair, DNA gap filling (GO:0006297)3.32398963
82ribosomal small subunit biogenesis (GO:0042274)3.30332773
83mitotic nuclear envelope disassembly (GO:0007077)3.27690799
84positive regulation of calcium ion transport into cytosol (GO:0010524)3.26777443
85RNA export from nucleus (GO:0006405)3.24528621
86mRNA transport (GO:0051028)3.23205269
87mitotic recombination (GO:0006312)3.21101440
88histone H2A acetylation (GO:0043968)3.18214981
89regulation of translational termination (GO:0006449)3.16265817
90regulation of mRNA splicing, via spliceosome (GO:0048024)3.14725722
91protein localization to kinetochore (GO:0034501)3.14398427
92regulation of sister chromatid cohesion (GO:0007063)3.14334602
93DNA ligation (GO:0006266)3.12878581
94folic acid metabolic process (GO:0046655)3.11925514
95sister chromatid cohesion (GO:0007062)3.09654356
96proline biosynthetic process (GO:0006561)3.07338599
97regulation of translational elongation (GO:0006448)3.05911572
98ATP-dependent chromatin remodeling (GO:0043044)3.05369190
99RNA splicing (GO:0008380)3.05276514
100cellular protein complex localization (GO:0034629)3.05023474
101water transport (GO:0006833)3.04749938
102nuclear envelope disassembly (GO:0051081)3.04223896
103membrane disassembly (GO:0030397)3.04223896
1043-UTR-mediated mRNA stabilization (GO:0070935)3.03755469
105positive regulation of wound healing (GO:0090303)3.03420913
106regulation of skeletal muscle fiber development (GO:0048742)3.02890181
107positive regulation of cell size (GO:0045793)3.01753189
108regulation of helicase activity (GO:0051095)3.01209857
109intermediate filament cytoskeleton organization (GO:0045104)3.01012993
110negative regulation of cell cycle G2/M phase transition (GO:1902750)3.00040184
111lens fiber cell development (GO:0070307)26.6511887
112lens fiber cell differentiation (GO:0070306)20.0706152
113alternative mRNA splicing, via spliceosome (GO:0000380)2.99279647
114protein localization to chromosome, centromeric region (GO:0071459)2.97721289
115chromatin remodeling at centromere (GO:0031055)2.97657204
116regulation of centriole replication (GO:0046599)2.97624387
117ribosome biogenesis (GO:0042254)2.97113998
118regulation of platelet aggregation (GO:0090330)2.95984851
119rRNA transcription (GO:0009303)2.94116984
120CENP-A containing nucleosome assembly (GO:0034080)2.93883279
121DNA replication-dependent nucleosome assembly (GO:0006335)2.93365621
122DNA replication-dependent nucleosome organization (GO:0034723)2.93365621
123ribonucleoprotein complex assembly (GO:0022618)2.93249468
124regulation of DNA damage checkpoint (GO:2000001)2.93209628
125DNA replication-independent nucleosome organization (GO:0034724)2.92873742
126DNA replication-independent nucleosome assembly (GO:0006336)2.92873742
127RNA stabilization (GO:0043489)2.92491694
128mRNA stabilization (GO:0048255)2.92491694
129mitotic metaphase plate congression (GO:0007080)2.91310874
130RNA transport (GO:0050658)2.90709277
131establishment of RNA localization (GO:0051236)2.90709277
132nucleic acid transport (GO:0050657)2.90709277
133intermediate filament-based process (GO:0045103)2.90197178
134cellular response to calcium ion (GO:0071277)2.90165765
135DNA unwinding involved in DNA replication (GO:0006268)2.88926260
136regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.83480411
137skeletal muscle organ development (GO:0060538)2.80668958
138regulation of Rac protein signal transduction (GO:0035020)2.71443195
139histone lysine demethylation (GO:0070076)2.61929096
140fluid transport (GO:0042044)2.59903297
141epithelial cell development (GO:0002064)2.53884272
142actomyosin structure organization (GO:0031032)2.50788174
143respiratory tube development (GO:0030323)2.48949041
144negative regulation of cell size (GO:0045792)2.44452653
145neuronal stem cell maintenance (GO:0097150)2.40471041
146histone demethylation (GO:0016577)2.40451443
147regulation of non-canonical Wnt signaling pathway (GO:2000050)2.40183573
148response to activity (GO:0014823)2.39365883
149negative regulation of platelet activation (GO:0010544)2.36010102
150regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.35356291
151prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.31562099
152activation of JUN kinase activity (GO:0007257)2.29410104
153apoptotic process involved in morphogenesis (GO:0060561)2.25909047
154peptidyl-lysine dimethylation (GO:0018027)2.21912204
155cerebellar granule cell differentiation (GO:0021707)2.21872340
156regulation of myotube differentiation (GO:0010830)2.21434996
157diaphragm development (GO:0060539)2.17486455
158protein localization to cell surface (GO:0034394)2.17235198
159planar cell polarity pathway involved in neural tube closure (GO:0090179)2.15630548
160mating behavior (GO:0007617)2.12904956
161apoptotic process involved in development (GO:1902742)2.12225324
162G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.11649316
163cell-cell junction assembly (GO:0007043)2.07148642
164positive regulation of dendrite morphogenesis (GO:0050775)2.06989291
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.06372600
166protein demethylation (GO:0006482)2.05818744
167protein dealkylation (GO:0008214)2.05818744
168positive regulation of dendritic spine development (GO:0060999)2.04687655
169epithelial cell differentiation involved in prostate gland development (GO:0060742)2.04616684
170response to osmotic stress (GO:0006970)2.03964689
171regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.03359727
172regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.00736796
173basement membrane organization (GO:0071711)2.00464298
174lens morphogenesis in camera-type eye (GO:0002089)10.4438488
175dorsal/ventral axis specification (GO:0009950)1.98285737
176L-alpha-amino acid transmembrane transport (GO:1902475)1.96118186
177protein trimerization (GO:0070206)1.94122866
178embryonic foregut morphogenesis (GO:0048617)1.91488519
179artery development (GO:0060840)1.91311462
180collecting duct development (GO:0072044)1.89675531
181bone trabecula formation (GO:0060346)1.86760620
182regulation of skeletal muscle tissue development (GO:0048641)1.85610312
183negative regulation of mRNA processing (GO:0050686)1.82677913
184positive regulation of cell cycle checkpoint (GO:1901978)1.82067865
185regulation of homotypic cell-cell adhesion (GO:0034110)1.80255498
186translesion synthesis (GO:0019985)1.78891780
187cell maturation (GO:0048469)1.78636930
188alpha-linolenic acid metabolic process (GO:0036109)1.77955678
189cellular response to vitamin D (GO:0071305)1.76554731
190ectoderm development (GO:0007398)1.75911092
191positive regulation of developmental growth (GO:0048639)1.75632644
192negative regulation of mRNA splicing, via spliceosome (GO:0048025)1.75280059
193short-term memory (GO:0007614)1.72430061
194dendritic spine morphogenesis (GO:0060997)1.72257323
195cytoskeletal anchoring at plasma membrane (GO:0007016)1.71076503
196metanephric nephron tubule development (GO:0072234)1.70820548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF652_21678463_ChIP-ChIP_ZR75-1_Human5.36689876
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse5.24625315
3CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.44652330
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse4.14270814
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.04196204
6IKZF1_21737484_ChIP-ChIP_HCT116_Human3.46066221
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38002993
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21252743
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.17216325
10XRN2_22483619_ChIP-Seq_HELA_Human3.14042457
11PCGF2_27294783_Chip-Seq_NPCs_Mouse3.07923906
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05941568
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91134685
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.87228159
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.83327500
16EGR1_19032775_ChIP-ChIP_M12_Human2.80661188
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78096455
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74575093
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68114286
20TTF2_22483619_ChIP-Seq_HELA_Human2.66020006
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.64586990
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64345338
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.60833110
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.57928324
25E2F7_22180533_ChIP-Seq_HELA_Human2.57501129
26BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.52848950
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52214229
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.44410462
29ZNF263_19887448_ChIP-Seq_K562_Human2.43716930
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.40680051
31PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37674511
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.33701555
33NANOG_16153702_ChIP-ChIP_HESCs_Human2.33632219
34GABP_17652178_ChIP-ChIP_JURKAT_Human2.28665193
35DCP1A_22483619_ChIP-Seq_HELA_Human2.26437514
36AR_21909140_ChIP-Seq_LNCAP_Human2.21194076
37KDM5A_27292631_Chip-Seq_BREAST_Human2.18602252
38* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18282226
39CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.14024520
40EED_16625203_ChIP-ChIP_MESCs_Mouse2.14005187
41NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12710789
42GABP_19822575_ChIP-Seq_HepG2_Human2.09403949
43E2F1_21310950_ChIP-Seq_MCF-7_Human2.08403709
44ZFX_18555785_ChIP-Seq_MESCs_Mouse2.01613558
45MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01419805
46BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse10.3742467
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85978918
48VDR_23849224_ChIP-Seq_CD4+_Human1.82030347
49CIITA_25753668_ChIP-Seq_RAJI_Human1.78584781
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76070997
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.73516012
52* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.73056703
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72378206
54FOXP3_21729870_ChIP-Seq_TREG_Human1.69505606
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69235502
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69051633
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.68530216
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67636146
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67009506
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.66180217
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.61020081
62* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.59087248
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.58323334
64* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.57884570
65* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.57884570
66ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57279737
67SOX2_22085726_ChIP-Seq_NPCs_Mouse1.56746494
68* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55815189
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.54843196
70* RNF2_27304074_Chip-Seq_ESCs_Mouse1.54366220
71TFEB_21752829_ChIP-Seq_HELA_Human1.53208072
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.52781885
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52603339
74CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.52486050
75EZH2_27294783_Chip-Seq_ESCs_Mouse1.52101843
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51821103
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.50311248
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46165069
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.45948189
80SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43697835
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41010001
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39954097
83* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39553257
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39297447
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37107518
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37081854
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36965237
88LXR_22292898_ChIP-Seq_THP-1_Human1.36685023
89SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36152396
90CTCF_18555785_Chip-Seq_ESCs_Mouse1.33984542
91HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31511344
92* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30908719
93JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30874041
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30759397
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29771299
96EZH2_22144423_ChIP-Seq_EOC_Human1.29395412
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29372426
98* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29156608
99ELK1_19687146_ChIP-ChIP_HELA_Human1.28513250
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28397533
101DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27875222
102EZH2_27294783_Chip-Seq_NPCs_Mouse1.27340808
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26679261
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.26364764
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25864292
106TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23805986
107ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21739279
108* TP53_20018659_ChIP-ChIP_R1E_Mouse1.21718004
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21101658
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20439271
111CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.20382132
112* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.18697929
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18453047
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17984353
115ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17943128
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17253743
117OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17184630
118* CBX2_27304074_Chip-Seq_ESCs_Mouse1.16404011
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15982536
120TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15969019
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15906908
122SMC3_22415368_ChIP-Seq_MEFs_Mouse1.15571983
123TBX3_20139965_ChIP-Seq_ESCs_Mouse1.15468564
124TP63_17297297_ChIP-ChIP_HaCaT_Human1.15119322
125RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15098405
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.14324593
127* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14186788
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13921376
129SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13743541
130NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13608128
131* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13354328
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12973720
133* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11923701
134MYC_22102868_ChIP-Seq_BL_Human1.11805821
135KDM2B_26808549_Chip-Seq_K562_Human1.11256495
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10513178
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08206804
138OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07120879
139CHD1_26751641_Chip-Seq_LNCaP_Human1.06451663
140NANOG_21062744_ChIP-ChIP_HESCs_Human1.06194099
141PU1_27457419_Chip-Seq_LIVER_Mouse1.06026576
142TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03817186
143* CTCF_27219007_Chip-Seq_Bcells_Human1.03462014
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02262930
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02158936
146KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01786222
147* RING1B_27294783_Chip-Seq_ESCs_Mouse1.00170839
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99212568
149SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98603073
150PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98166118
151SALL4_22934838_ChIP-ChIP_CD34+_Human0.97772340
152TCF7_22412390_ChIP-Seq_EML_Mouse0.97194352
153SRF_21415370_ChIP-Seq_HL-1_Mouse0.97166578
154ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96936726
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96688932
156* MYC_18940864_ChIP-ChIP_HL60_Human0.96011297
157SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95279459
158CLOCK_20551151_ChIP-Seq_293T_Human0.94721651
159TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94641298
160SMAD3_21741376_ChIP-Seq_ESCs_Human0.94378781
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93869109
162EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93686350
163CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93086662
164CTCF_21964334_Chip-Seq_Bcells_Human0.92721270
165* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92550754
166EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92469607
167SOX2_16153702_ChIP-ChIP_HESCs_Human0.92344051
168* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90117309
169ZNF274_21170338_ChIP-Seq_K562_Hela0.89449208
170SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89230407
171* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88939427
172GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88467402
173DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88023038
174* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87625669
175KDM2B_26808549_Chip-Seq_JURKAT_Human0.87562041
176FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86597933
177KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86411903
178CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85334126
179CJUN_26792858_Chip-Seq_BT549_Human0.85112909
180RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85001255
181PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84740972
182SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.84280511
183ESR2_21235772_ChIP-Seq_MCF-7_Human0.82082488
184TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81681282
185SALL1_21062744_ChIP-ChIP_HESCs_Human0.80252819
186SOX17_20123909_ChIP-Seq_XEN_Mouse0.79669175
187ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78202258
188FOXP1_21924763_ChIP-Seq_HESCs_Human0.77473783
189E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.74656592
190* FUS_26573619_Chip-Seq_HEK293_Human0.74443344
191SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74063001
192CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72780484
193EWS_26573619_Chip-Seq_HEK293_Human0.72731229
194STAT3_1855785_ChIP-Seq_MESCs_Mouse0.72688977
195FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70952152
196NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.69120625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005193_abnormal_anterior_eye8.78606940
2MP0010094_abnormal_chromosome_stability6.36022096
3MP0008058_abnormal_DNA_repair6.31919259
4MP0008057_abnormal_DNA_replication5.64036040
5MP0003693_abnormal_embryo_hatching5.59745000
6MP0008007_abnormal_cellular_replicative5.31141382
7MP0005253_abnormal_eye_physiology4.88461662
8MP0003077_abnormal_cell_cycle4.45384394
9MP0003111_abnormal_nucleus_morphology4.41270877
10MP0002092_abnormal_eye_morphology4.09808949
11MP0004957_abnormal_blastocyst_morpholog3.84964755
12MP0000749_muscle_degeneration3.69814119
13* MP0001286_abnormal_eye_development3.32847016
14MP0005391_vision/eye_phenotype3.32049868
15MP0003941_abnormal_skin_development3.17772259
16MP0008932_abnormal_embryonic_tissue2.84527217
17MP0000350_abnormal_cell_proliferation2.71213791
18MP0001346_abnormal_lacrimal_gland2.63890513
19MP0009672_abnormal_birth_weight2.61793314
20MP0002090_abnormal_vision2.42328746
21* MP0005197_abnormal_uvea_morphology2.30582048
22MP0000537_abnormal_urethra_morphology2.15792331
23* MP0002697_abnormal_eye_size13.6152709
24MP0002108_abnormal_muscle_morphology1.80672027
25MP0001672_abnormal_embryogenesis/_devel1.78429914
26MP0005380_embryogenesis_phenotype1.78429914
27MP0000313_abnormal_cell_death1.70189711
28MP0004272_abnormal_basement_membrane1.65017768
29MP0010307_abnormal_tumor_latency1.62366011
30MP0003786_premature_aging1.58623132
31MP0003283_abnormal_digestive_organ1.52080504
32MP0009053_abnormal_anal_canal1.51239265
33MP0002080_prenatal_lethality1.50612855
34MP0005330_cardiomyopathy1.50147812
35MP0009703_decreased_birth_body1.49850072
36MP0001697_abnormal_embryo_size1.47438271
37MP0002085_abnormal_embryonic_tissue1.43943982
38MP0005623_abnormal_meninges_morphology1.43694482
39MP0002638_abnormal_pupillary_reflex1.41734828
40MP0002269_muscular_atrophy1.39237337
41MP0003221_abnormal_cardiomyocyte_apopto1.38977481
42MP0000343_altered_response_to1.34011399
43MP0006035_abnormal_mitochondrial_morpho1.32299565
44MP0010368_abnormal_lymphatic_system1.29822173
45MP0001299_abnormal_eye_distance/1.21627675
46MP0010352_gastrointestinal_tract_polyps1.19324322
47MP0002234_abnormal_pharynx_morphology1.14874178
48MP0001293_anophthalmia1.09409100
49MP0000003_abnormal_adipose_tissue1.03949153
50MP0003937_abnormal_limbs/digits/tail_de1.03342051
51MP0002735_abnormal_chemical_nociception1.03130667
52MP0008995_early_reproductive_senescence1.02875919
53MP0001661_extended_life_span1.00390212
54MP0001929_abnormal_gametogenesis0.99889640
55MP0000358_abnormal_cell_content/0.99711350
56MP0003943_abnormal_hepatobiliary_system0.96227130
57MP0003646_muscle_fatigue0.90044507
58MP0002282_abnormal_trachea_morphology0.88302742
59MP0005058_abnormal_lysosome_morphology0.87996943
60MP0003705_abnormal_hypodermis_morpholog0.87355670
61MP0005384_cellular_phenotype0.86363311
62MP0002210_abnormal_sex_determination0.86125765
63MP0002653_abnormal_ependyma_morphology0.85352795
64MP0002160_abnormal_reproductive_system0.84986103
65MP0008961_abnormal_basal_metabolism0.84327428
66MP0002139_abnormal_hepatobiliary_system0.84007539
67MP0003123_paternal_imprinting0.82387940
68MP0002009_preneoplasia0.81652744
69MP0005503_abnormal_tendon_morphology0.81651824
70MP0000049_abnormal_middle_ear0.81624676
71MP0005621_abnormal_cell_physiology0.81387159
72MP0001145_abnormal_male_reproductive0.79057258
73MP0002114_abnormal_axial_skeleton0.76251379
74MP0002019_abnormal_tumor_incidence0.75673203
75MP0000490_abnormal_crypts_of0.75301122
76MP0005248_abnormal_Harderian_gland0.74756190
77MP0006036_abnormal_mitochondrial_physio0.74378889
78MP0010030_abnormal_orbit_morphology0.73546401
79MP0001727_abnormal_embryo_implantation0.72722053
80MP0003119_abnormal_digestive_system0.70755229
81* MP0005195_abnormal_posterior_eye0.69465729
82MP0005319_abnormal_enzyme/_coenzyme0.69431442
83MP0003806_abnormal_nucleotide_metabolis0.69312478
84MP0002928_abnormal_bile_duct0.68861500
85MP0000428_abnormal_craniofacial_morphol0.68813168
86MP0003115_abnormal_respiratory_system0.68092773
87MP0003122_maternal_imprinting0.67706565
88MP0004087_abnormal_muscle_fiber0.65854352
89MP0000653_abnormal_sex_gland0.64495869
90MP0005187_abnormal_penis_morphology0.62980031
91MP0000678_abnormal_parathyroid_gland0.62756462
92MP0003718_maternal_effect0.62423572
93MP0005369_muscle_phenotype0.61092794
94MP0003385_abnormal_body_wall0.61016967
95MP0002249_abnormal_larynx_morphology0.60336823
96MP0001915_intracranial_hemorrhage0.58135193
97MP0001188_hyperpigmentation0.57586677
98MP0003698_abnormal_male_reproductive0.57472478
99MP0005076_abnormal_cell_differentiation0.55812587
100MP0004185_abnormal_adipocyte_glucose0.54994165
101MP0004808_abnormal_hematopoietic_stem0.53833750
102MP0004084_abnormal_cardiac_muscle0.53019213
103MP0000778_abnormal_nervous_system0.52551554
104MP0003566_abnormal_cell_adhesion0.52416161
105MP0004197_abnormal_fetal_growth/weight/0.51554374
106MP0000383_abnormal_hair_follicle0.50827372
107MP0000759_abnormal_skeletal_muscle0.50069660
108MP0004859_abnormal_synaptic_plasticity0.49798342
109MP0002233_abnormal_nose_morphology0.49750864
110MP0010678_abnormal_skin_adnexa0.49034614
111MP0005375_adipose_tissue_phenotype0.48632245
112MP0005551_abnormal_eye_electrophysiolog0.46897225
113MP0000566_synostosis0.46735431
114MP0002932_abnormal_joint_morphology0.46031892
115MP0002161_abnormal_fertility/fecundity0.45187180
116MP0001905_abnormal_dopamine_level0.44298713
117MP0009697_abnormal_copulation0.42931114
118MP0003755_abnormal_palate_morphology0.42691360
119MP0002736_abnormal_nociception_after0.42066283
120MP0003942_abnormal_urinary_system0.40960751
121MP0000013_abnormal_adipose_tissue0.39967472
122MP0000516_abnormal_urinary_system0.39858918
123MP0005367_renal/urinary_system_phenotyp0.39858918
124MP0003121_genomic_imprinting0.39698502
125MP0001529_abnormal_vocalization0.39561431
126MP0002837_dystrophic_cardiac_calcinosis0.39293179
127MP0004233_abnormal_muscle_weight0.38880211
128MP0003861_abnormal_nervous_system0.38757503
129MP0005220_abnormal_exocrine_pancreas0.38684339
130MP0010630_abnormal_cardiac_muscle0.38559054
131MP0001968_abnormal_touch/_nociception0.38125087
132MP0001943_abnormal_respiration0.36515865
133MP0001958_emphysema0.35923223
134MP0002177_abnormal_outer_ear0.34435695
135MP0002152_abnormal_brain_morphology0.33570785
136MP0000955_abnormal_spinal_cord0.32611613
137* MP0001340_abnormal_eyelid_morphology0.32364467
138MP0009250_abnormal_appendicular_skeleto0.32063165
139MP0002734_abnormal_mechanical_nocicepti0.31651088
140MP0003315_abnormal_perineum_morphology0.30858826
141MP0003959_abnormal_lean_body0.30575606
142MP0000465_gastrointestinal_hemorrhage0.30309059
143MP0010234_abnormal_vibrissa_follicle0.30071889
144MP0003252_abnormal_bile_duct0.29969876
145MP0003635_abnormal_synaptic_transmissio0.28658047
146MP0002089_abnormal_postnatal_growth/wei0.28380193
147MP0005085_abnormal_gallbladder_physiolo0.28011804
148MP0004134_abnormal_chest_morphology0.27695528
149MP0005257_abnormal_intraocular_pressure0.26443155
150MP0005083_abnormal_biliary_tract0.26108554
151MP0002102_abnormal_ear_morphology0.24938031
152MP0001784_abnormal_fluid_regulation0.24685799
153MP0006292_abnormal_olfactory_placode0.24184652
154MP0002081_perinatal_lethality0.23798059
155MP0009780_abnormal_chondrocyte_physiolo0.23678604
156MP0000534_abnormal_ureter_morphology0.23135848
157MP0002063_abnormal_learning/memory/cond0.23095180
158MP0003984_embryonic_growth_retardation0.22475382
159MP0004811_abnormal_neuron_physiology0.22121561
160MP0002086_abnormal_extraembryonic_tissu0.22099031
161MP0002088_abnormal_embryonic_growth/wei0.22078592
162MP0003787_abnormal_imprinting0.21807487
163MP0001730_embryonic_growth_arrest0.21427675
164MP0003938_abnormal_ear_development0.21349677
165MP0000747_muscle_weakness0.21288598
166MP0000266_abnormal_heart_morphology0.21142009
167MP0003935_abnormal_craniofacial_develop0.20571506
168MP0002116_abnormal_craniofacial_bone0.20370395
169MP0002084_abnormal_developmental_patter0.20299879

Predicted human phenotypes

RankGene SetZ-score
1Congenital cataract (HP:0000519)8.09432603
2Corneal dystrophy (HP:0001131)7.17998635
3Amblyopia (HP:0000646)7.01996035
4Chromsome breakage (HP:0040012)5.19388652
5Chromosomal breakage induced by crosslinking agents (HP:0003221)5.08942263
6Birth length less than 3rd percentile (HP:0003561)4.51821006
7Progressive muscle weakness (HP:0003323)4.27336739
8Clumsiness (HP:0002312)4.22429323
9Abnormality of the phalanges of the hallux (HP:0010057)4.18775416
10Progressive external ophthalmoplegia (HP:0000590)4.08723708
11Volvulus (HP:0002580)3.68869431
12Microcornea (HP:0000482)3.65868103
13Multiple enchondromatosis (HP:0005701)3.64143618
14Calcaneovalgus deformity (HP:0001848)3.43389476
15Microvesicular hepatic steatosis (HP:0001414)3.29339459
16High anterior hairline (HP:0009890)3.27591528
17Proximal placement of thumb (HP:0009623)3.25793290
18Ragged-red muscle fibers (HP:0003200)3.24368307
19Reticulocytopenia (HP:0001896)3.23111499
20Abnormal umbilical cord blood vessels (HP:0011403)3.20493911
21Single umbilical artery (HP:0001195)3.20493911
22Abnormality of the fetal cardiovascular system (HP:0010948)3.20493911
23Rectovaginal fistula (HP:0000143)3.12335334
24Rectal fistula (HP:0100590)3.12335334
25Iris coloboma (HP:0000612)3.05154605
26Smooth philtrum (HP:0000319)3.04224532
27Nuclear cataract (HP:0100018)28.0016752
28Zonular cataract (HP:0010920)24.7121110
29Microretrognathia (HP:0000308)2.98020276
30Deformed tarsal bones (HP:0008119)2.94779850
31Intestinal fistula (HP:0100819)2.91653961
32Abnormality of cochlea (HP:0000375)2.87363318
33Deviation of the thumb (HP:0009603)2.87361047
34Gout (HP:0001997)2.80370461
35Increased nuchal translucency (HP:0010880)2.79282993
36Eosinophilia (HP:0001880)2.76024180
37Degeneration of anterior horn cells (HP:0002398)2.72322667
38Abnormality of the anterior horn cell (HP:0006802)2.72322667
39Duplication of thumb phalanx (HP:0009942)2.67599635
40Premature ovarian failure (HP:0008209)2.66499409
41Sparse lateral eyebrow (HP:0005338)2.65225535
42Urethral obstruction (HP:0000796)2.63975218
43Abnormality of chromosome stability (HP:0003220)2.63921895
44Facial cleft (HP:0002006)2.61888722
45Vaginal fistula (HP:0004320)2.58271704
46Septate vagina (HP:0001153)2.48688505
47Abnormality of the distal phalanx of the thumb (HP:0009617)2.48552562
48Abnormality of the calcaneus (HP:0008364)2.47109246
49Limb hypertonia (HP:0002509)2.44565099
50Abnormality of the umbilical cord (HP:0010881)2.44542893
51* Polar cataract (HP:0010696)2.42067427
52Ectopic kidney (HP:0000086)2.40893811
53Secondary amenorrhea (HP:0000869)2.40129404
54Deep philtrum (HP:0002002)2.34336057
55Duplicated collecting system (HP:0000081)2.33590405
56Abnormality of the columella (HP:0009929)2.32545559
57Testicular atrophy (HP:0000029)2.31806368
58Increased serum pyruvate (HP:0003542)2.30600578
59Trismus (HP:0000211)2.27874126
60Resting tremor (HP:0002322)2.25585794
61* Opacification of the corneal stroma (HP:0007759)2.25217119
62Glossoptosis (HP:0000162)2.22747143
63Cafe-au-lait spot (HP:0000957)2.21372687
64Partial duplication of thumb phalanx (HP:0009944)2.21250746
65Granulocytopenia (HP:0001913)2.18349767
66Preauricular skin tag (HP:0000384)2.17266980
67Scapular winging (HP:0003691)2.17022191
68Abnormality of glycolysis (HP:0004366)2.16671681
69Atresia of the external auditory canal (HP:0000413)2.16283371
70Proximal amyotrophy (HP:0007126)2.12478107
71Broad distal phalanx of finger (HP:0009836)2.11533689
72Abnormality of the preputium (HP:0100587)2.10915031
73Dysphonia (HP:0001618)2.10476296
74Long eyelashes (HP:0000527)2.09429592
75Anal atresia (HP:0002023)2.05006964
76Meckel diverticulum (HP:0002245)2.03440361
77Prominent nose (HP:0000448)2.01681364
78Morphological abnormality of the inner ear (HP:0011390)2.01111033
79Triphalangeal thumb (HP:0001199)2.00356153
80Myelodysplasia (HP:0002863)1.99306292
81Selective tooth agenesis (HP:0001592)1.97151113
82Skin tags (HP:0010609)1.93491264
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.92950316
84Absent radius (HP:0003974)1.91621139
85Abnormality of the renal collecting system (HP:0004742)1.91602222
86Partial duplication of the phalanx of hand (HP:0009999)1.91511394
87Cortical dysplasia (HP:0002539)1.90782876
88Abnormality of eosinophils (HP:0001879)1.90663174
89* Anterior segment dysgenesis (HP:0007700)1.88549219
90Abnormality of the fingertips (HP:0001211)1.88243503
91Abnormal cartilage morphology (HP:0002763)1.87868286
92Abnormality of the ileum (HP:0001549)1.87157879
93Spastic diplegia (HP:0001264)1.86438111
94Abnormal connection of the cardiac segments (HP:0011545)1.83537172
95Abnormal ventriculo-arterial connection (HP:0011563)1.83537172
96Transposition of the great arteries (HP:0001669)1.83537172
97Ureteral duplication (HP:0000073)1.81471911
98Pseudobulbar signs (HP:0002200)1.81059952
99Preaxial hand polydactyly (HP:0001177)1.81025115
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78382150
101Deep palmar crease (HP:0006191)1.77795941
102Sloping forehead (HP:0000340)1.77000514
103Aplasia involving forearm bones (HP:0009822)1.76665607
104Absent forearm bone (HP:0003953)1.76665607
105Low anterior hairline (HP:0000294)1.75439505
106Medulloblastoma (HP:0002885)1.74596110
107Capillary hemangiomas (HP:0005306)1.74198556
108Dysmetric saccades (HP:0000641)1.73552603
109Tetraplegia (HP:0002445)1.73170624
110Prominent metopic ridge (HP:0005487)1.73113815
111Truncus arteriosus (HP:0001660)1.72744909
112Posterior subcapsular cataract (HP:0007787)1.72105194
113Neoplasm of the adrenal cortex (HP:0100641)1.70788389
114Aplasia/Hypoplasia of the macula (HP:0008059)1.65822358
115Neonatal respiratory distress (HP:0002643)1.65590365
116Aplasia/Hypoplasia affecting the retina (HP:0008061)1.54708869
117Aplasia of the musculature (HP:0100854)1.52277034
118Long clavicles (HP:0000890)1.52176732
119Fetal akinesia sequence (HP:0001989)1.50608738
120Popliteal pterygium (HP:0009756)1.44092992
121Amniotic constriction ring (HP:0009775)1.43555986
122Abnormality of placental membranes (HP:0011409)1.43555986
123Abnormality of the shoulder girdle musculature (HP:0001435)1.34270053
124Leukocytosis (HP:0001974)1.27867696
125Fused cervical vertebrae (HP:0002949)1.24092879
126Hypoplastic nipples (HP:0002557)1.23742761
127Difficulty walking (HP:0002355)1.21807010
128Akinesia (HP:0002304)1.20081778
129Abnormal number of incisors (HP:0011064)1.17266869
130Vertebral clefting (HP:0008428)1.08532183
131Rib fusion (HP:0000902)1.06331953
132Symphalangism affecting the phalanges of the hand (HP:0009773)1.05772146
133Abnormality of the labia majora (HP:0012881)1.05424529
134Aplasia/Hypoplasia involving the musculature (HP:0001460)0.99391793
135Ependymoma (HP:0002888)0.98164009
136Pterygium (HP:0001059)0.87188240
137Subcapsular cataract (HP:0000523)0.86339721
138Lymphangioma (HP:0100764)0.84530936
139Chorioretinal coloboma (HP:0000567)0.79984754
140Exostoses (HP:0100777)0.79892368
141* Sclerocornea (HP:0000647)0.77809869
142Camptodactyly of toe (HP:0001836)0.77280839
143Neoplasm of the heart (HP:0100544)0.75987416
144Hypoplastic heart (HP:0001961)0.70329306
145* Abnormality of the anterior chamber (HP:0000593)0.70173097
146Thin ribs (HP:0000883)0.68407663
147Pointed chin (HP:0000307)0.67317069
148Astrocytoma (HP:0009592)0.66386717
149Abnormality of the astrocytes (HP:0100707)0.66386717
150Malignant hyperthermia (HP:0002047)0.66356941
151Split foot (HP:0001839)0.66286691
152Aplasia/Hypoplasia of the nipples (HP:0006709)0.62794890
153Hypoplastic pelvis (HP:0008839)0.61018052
154Patellar aplasia (HP:0006443)0.60073718
155Dislocated radial head (HP:0003083)0.59250404
156Abnormality of the humeroradial joint (HP:0100744)0.58398703
157Abnormality of the radial head (HP:0003995)0.55658542
158Annular pancreas (HP:0001734)0.55080591
159Joint contractures involving the joints of the feet (HP:0100492)0.54113787
160Flexion contracture of toe (HP:0005830)0.54113787
161Aplasia/Hypoplasia of the patella (HP:0006498)0.52769820
162Visceral angiomatosis (HP:0100761)0.52216955
163Porencephaly (HP:0002132)0.51941518
164Humeroradial synostosis (HP:0003041)0.51891473
165Synostosis involving the elbow (HP:0003938)0.51891473
166Bilateral microphthalmos (HP:0007633)0.50686884
167Hepatoblastoma (HP:0002884)0.49018185
168Glioma (HP:0009733)0.48775652
169Severe visual impairment (HP:0001141)0.48575049
170Hemangiomatosis (HP:0007461)0.48049425
171Skin nodule (HP:0200036)0.47331405
172Abnormality of the labia (HP:0000058)0.46970384
173Enlarged kidneys (HP:0000105)0.46486118
174Diminished movement (HP:0002374)0.46448191
175* Autosomal dominant inheritance (HP:0000006)0.46047950
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)0.45219520
177Muscle fiber splitting (HP:0003555)0.45039207
178Abnormal pancreas size (HP:0012094)0.43935362
179Buphthalmos (HP:0000557)0.43015788
180Skull defect (HP:0001362)0.42712246
181Megalencephaly (HP:0001355)0.42705126
182Cystic hygroma (HP:0000476)0.42654753
183Abnormalities of placenta or umbilical cord (HP:0001194)0.42238692
184Broad nasal tip (HP:0000455)0.42178203
185Angiofibromas (HP:0010615)0.41802732
186Adenoma sebaceum (HP:0009720)0.41802732
187Neonatal hypoglycemia (HP:0001998)0.41775693
188Oligodactyly (hands) (HP:0001180)0.41005641
189Vertebral fusion (HP:0002948)0.40483245
190Hamartoma of the eye (HP:0010568)0.40054558
191Telecanthus (HP:0000506)0.39783139
192Ankyloglossia (HP:0010296)0.39714009
193Abnormality of the incisor (HP:0000676)0.39705104
194Hypopigmentation of the fundus (HP:0007894)0.39482091
195Atelectasis (HP:0100750)0.39398078
196Hyporeflexia of lower limbs (HP:0002600)0.39287531

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP2K67.69264695
2BLK4.58102861
3EPHB24.05544288
4SGK13.65795694
5SRPK13.49587338
6STK392.78497067
7KSR12.71394355
8WNK42.53039728
9BUB12.44546588
10PRKG12.28747760
11ERBB22.26613952
12MAP3K102.12962195
13SMG12.11028933
14SIK12.09529213
15NTRK11.99830156
16FLT31.95332801
17PNCK1.86301501
18MST41.83710837
19BRD41.75467236
20PAK41.69819949
21EEF2K1.65069546
22STK161.64662555
23TTK1.62698018
24ICK1.60744183
25LRRK21.59383730
26PLK41.57778447
27PKN21.52036497
28EIF2AK11.46545780
29TRIB31.45878908
30PRKCB1.44899257
31MET1.42481471
32IRAK31.39511049
33CHEK21.39488098
34VRK21.39089599
35IGF1R1.36661855
36CAMK1D1.36297565
37PLK31.35844656
38NEK11.35275515
39ATR1.33522282
40MAPK101.32831726
41PDGFRA1.31451711
42CSNK1A1L1.24503315
43PASK1.23675458
44INSR1.23592643
45CSNK1G31.22865705
46ERBB31.20714045
47BCR1.18244281
48CHEK11.17710992
49SCYL21.16644259
50PTK61.14944742
51PRKACB1.14350408
52FGFR21.13941004
53BRAF1.11898803
54CAMK1G1.08803873
55MINK11.07956475
56SIK31.05653936
57CSNK1G11.04671462
58CDK71.04024709
59PBK1.02644173
60CDK40.99101828
61ROCK20.97504395
62PLK10.96477631
63AKT30.92148101
64RPS6KA30.91861416
65CDK120.91384463
66MKNK20.88636461
67NEK20.88462025
68ILK0.87231706
69SIK20.87023198
70ATM0.84649706
71KDR0.83619060
72UHMK10.83054861
73CDK190.82071300
74STK100.81736302
75TAF10.81628182
76CSNK1G20.81410935
77DYRK30.80304107
78CDK20.78956438
79MAPKAPK50.78855983
80CDK60.76212320
81CAMKK10.75542801
82ZAP700.75194932
83BRSK10.73521766
84FGFR10.72225471
85AURKB0.71661314
86CDC70.70705330
87TGFBR10.70157772
88CCNB10.69239910
89PKN10.69093797
90PRKCQ0.63558034
91MAP3K90.62277144
92EPHA20.62197331
93AURKA0.61989106
94PRKACG0.60130935
95PTK20.58851895
96MAP3K140.58725739
97RPS6KA10.57779856
98WNK10.57601352
99NME10.56868842
100EPHA40.51889882
101LATS10.51011148
102CSNK2A20.50761432
103AKT20.49605413
104MKNK10.48192116
105MTOR0.48119370
106PRKDC0.45643498
107RPS6KA20.44059542
108PHKG20.41914315
109PHKG10.41914315
110IRAK20.41904788
111CSNK2A10.40941668
112NTRK30.39776788
113ROCK10.38452993
114RPS6KC10.38098191
115RPS6KL10.38098191
116CDK30.36852743
117TTN0.36035356
118EIF2AK20.35533144
119PRKAA10.34999742
120PAK60.34221345
121ALK0.33744396
122PAK30.33389965
123MAPK140.33156646
124HIPK20.32167757
125KSR20.31815799
126ARAF0.31604323
127CSNK1E0.30776078
128MAPKAPK20.29219770
129PIM10.28634990
130CAMK40.28294319
131LATS20.28263745
132MAP2K40.27707868
133MAPK150.27627972
134WEE10.27416031
135CSF1R0.27354269
136PLK20.27236250
137ACVR1B0.26805964
138MAP3K130.26475648
139MAP3K80.25879306
140NEK90.25316799
141PAK20.24792866
142ADRBK10.24552641
143DAPK10.24387083
144AKT10.24139408
145CDK140.23616042
146SGK2230.23575328
147SGK4940.23575328
148CSNK1D0.23152217
149GSK3B0.22748227
150TSSK60.22360027
151NME20.22313267
152VRK10.22030966
153EGFR0.21652622
154CDK80.21432289
155FER0.21029455
156CDK10.20997090
157SGK30.20627109
158RPS6KA60.20393087
159BRSK20.19955702
160CDK11A0.17319767
161CSNK1A10.16582878
162IRAK40.16560344
163EIF2AK30.16247385
164CDK90.15921341

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.01116106
2Hedgehog signaling pathway_Homo sapiens_hsa043403.64289436
3Non-homologous end-joining_Homo sapiens_hsa034503.33107834
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.20711778
5RNA transport_Homo sapiens_hsa030133.13185517
6Homologous recombination_Homo sapiens_hsa034403.02559171
7Base excision repair_Homo sapiens_hsa034103.02454707
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.94323213
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71845422
10Hippo signaling pathway_Homo sapiens_hsa043902.59306595
11Nucleotide excision repair_Homo sapiens_hsa034202.41279504
12Small cell lung cancer_Homo sapiens_hsa052222.31035262
13One carbon pool by folate_Homo sapiens_hsa006702.30716786
14Melanogenesis_Homo sapiens_hsa049162.24223002
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.11378108
16DNA replication_Homo sapiens_hsa030302.07759502
17Central carbon metabolism in cancer_Homo sapiens_hsa052301.98370019
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98060794
19Proteasome_Homo sapiens_hsa030501.90788859
20Legionellosis_Homo sapiens_hsa051341.90246891
21Nitrogen metabolism_Homo sapiens_hsa009101.90053699
22RNA polymerase_Homo sapiens_hsa030201.83611977
23Fanconi anemia pathway_Homo sapiens_hsa034601.82781219
24Adherens junction_Homo sapiens_hsa045201.78300841
25Wnt signaling pathway_Homo sapiens_hsa043101.77333187
26Steroid biosynthesis_Homo sapiens_hsa001001.76187776
27Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70669008
28Biosynthesis of amino acids_Homo sapiens_hsa012301.64018391
29RNA degradation_Homo sapiens_hsa030181.61891363
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.59191577
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58965482
32Proteoglycans in cancer_Homo sapiens_hsa052051.58343471
33Pyrimidine metabolism_Homo sapiens_hsa002401.57991368
34Basal transcription factors_Homo sapiens_hsa030221.50183457
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41178879
36Lysine degradation_Homo sapiens_hsa003101.39595903
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34877528
38Axon guidance_Homo sapiens_hsa043601.33531112
39Circadian entrainment_Homo sapiens_hsa047131.32766241
40mTOR signaling pathway_Homo sapiens_hsa041501.29194352
41Dorso-ventral axis formation_Homo sapiens_hsa043201.27787086
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21672580
43ECM-receptor interaction_Homo sapiens_hsa045121.19985351
44Antigen processing and presentation_Homo sapiens_hsa046121.18494449
45Tight junction_Homo sapiens_hsa045301.17689597
46mRNA surveillance pathway_Homo sapiens_hsa030151.17353101
47Ribosome_Homo sapiens_hsa030101.16556547
48Carbon metabolism_Homo sapiens_hsa012001.13265209
49MicroRNAs in cancer_Homo sapiens_hsa052061.10238234
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09806296
51Arginine biosynthesis_Homo sapiens_hsa002201.09630895
52Sulfur relay system_Homo sapiens_hsa041221.09440041
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05912238
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04314382
55Pathways in cancer_Homo sapiens_hsa052001.04239351
56Spliceosome_Homo sapiens_hsa030401.03736087
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.02830503
58Pyruvate metabolism_Homo sapiens_hsa006201.01746315
59Circadian rhythm_Homo sapiens_hsa047101.00612679
60Fatty acid metabolism_Homo sapiens_hsa012121.00452053
61Renal cell carcinoma_Homo sapiens_hsa052111.00042529
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98780989
63Gap junction_Homo sapiens_hsa045400.98239337
64Insulin signaling pathway_Homo sapiens_hsa049100.98210139
65Bladder cancer_Homo sapiens_hsa052190.98021011
66Epstein-Barr virus infection_Homo sapiens_hsa051690.97002958
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96846587
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.96394273
69Glioma_Homo sapiens_hsa052140.96361595
70Arginine and proline metabolism_Homo sapiens_hsa003300.95074574
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94956806
72Glucagon signaling pathway_Homo sapiens_hsa049220.94950526
73Bile secretion_Homo sapiens_hsa049760.93444447
74Olfactory transduction_Homo sapiens_hsa047400.92310657
75Purine metabolism_Homo sapiens_hsa002300.89039900
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86574843
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86565927
78Fatty acid degradation_Homo sapiens_hsa000710.83877058
79Maturity onset diabetes of the young_Homo sapiens_hsa049500.83830528
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.83718833
81Focal adhesion_Homo sapiens_hsa045100.80273653
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78547031
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.77876885
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77655568
85Mismatch repair_Homo sapiens_hsa034300.75974841
86Protein digestion and absorption_Homo sapiens_hsa049740.74630933
87Long-term potentiation_Homo sapiens_hsa047200.73754397
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72799710
89Glutathione metabolism_Homo sapiens_hsa004800.71540259
90GABAergic synapse_Homo sapiens_hsa047270.69927761
91Vibrio cholerae infection_Homo sapiens_hsa051100.69795186
92Pentose phosphate pathway_Homo sapiens_hsa000300.69779238
93Amoebiasis_Homo sapiens_hsa051460.69386663
94Protein export_Homo sapiens_hsa030600.68284618
95Selenocompound metabolism_Homo sapiens_hsa004500.66633033
96Thyroid cancer_Homo sapiens_hsa052160.65548041
97Prion diseases_Homo sapiens_hsa050200.65537024
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63887731
99Notch signaling pathway_Homo sapiens_hsa043300.63479868
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62489240
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62477820
102Insulin secretion_Homo sapiens_hsa049110.62251197
103Folate biosynthesis_Homo sapiens_hsa007900.61891861
104Type II diabetes mellitus_Homo sapiens_hsa049300.60575794
105HTLV-I infection_Homo sapiens_hsa051660.59837947
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59161132
107Butanoate metabolism_Homo sapiens_hsa006500.56639620
108Cell cycle_Homo sapiens_hsa041100.55290726
109Dopaminergic synapse_Homo sapiens_hsa047280.54807536
110Oocyte meiosis_Homo sapiens_hsa041140.51072250
111Fatty acid elongation_Homo sapiens_hsa000620.50874867
112Propanoate metabolism_Homo sapiens_hsa006400.50818755
113Estrogen signaling pathway_Homo sapiens_hsa049150.50696820
114Long-term depression_Homo sapiens_hsa047300.50520419
115Chronic myeloid leukemia_Homo sapiens_hsa052200.50366705
116Huntingtons disease_Homo sapiens_hsa050160.50111725
117Rap1 signaling pathway_Homo sapiens_hsa040150.49794553
118Tryptophan metabolism_Homo sapiens_hsa003800.49489361
119AMPK signaling pathway_Homo sapiens_hsa041520.49476714
120Prostate cancer_Homo sapiens_hsa052150.48943980
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48244121
122Other glycan degradation_Homo sapiens_hsa005110.45744082
123Alcoholism_Homo sapiens_hsa050340.45221874
124Synaptic vesicle cycle_Homo sapiens_hsa047210.44398592
125Herpes simplex infection_Homo sapiens_hsa051680.43976233
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.43799451
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43343959
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.41586352
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40602536
130Glutamatergic synapse_Homo sapiens_hsa047240.40379171
131Viral myocarditis_Homo sapiens_hsa054160.39315226
132Fructose and mannose metabolism_Homo sapiens_hsa000510.39293981
133Regulation of autophagy_Homo sapiens_hsa041400.38936444
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37815944
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36649101
136Cholinergic synapse_Homo sapiens_hsa047250.36612091
137Cocaine addiction_Homo sapiens_hsa050300.35611149
138Oxytocin signaling pathway_Homo sapiens_hsa049210.35031853
139Parkinsons disease_Homo sapiens_hsa050120.33998069
140Non-small cell lung cancer_Homo sapiens_hsa052230.31831272
141Measles_Homo sapiens_hsa051620.29048727
142Phenylalanine metabolism_Homo sapiens_hsa003600.27166020
143Influenza A_Homo sapiens_hsa051640.25073857
144Viral carcinogenesis_Homo sapiens_hsa052030.23482699
145FoxO signaling pathway_Homo sapiens_hsa040680.23356539
146TGF-beta signaling pathway_Homo sapiens_hsa043500.18913027
147Colorectal cancer_Homo sapiens_hsa052100.15583566
148Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14710559
149Apoptosis_Homo sapiens_hsa042100.14702556
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.12674164
151p53 signaling pathway_Homo sapiens_hsa041150.12323667
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10565051
153Toxoplasmosis_Homo sapiens_hsa051450.10147008
154Inositol phosphate metabolism_Homo sapiens_hsa005620.09120219
155Metabolic pathways_Homo sapiens_hsa011000.08819065
156Fatty acid biosynthesis_Homo sapiens_hsa000610.05193222
157MAPK signaling pathway_Homo sapiens_hsa040100.03908325
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03870942
159Oxidative phosphorylation_Homo sapiens_hsa001900.02176699
160Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.01893652

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