ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ATP (GO:0071318)	9.80341461
2	negative regulation of cell aging (GO:0090344)	9.12799999
3	regulation of skeletal muscle contraction (GO:0014819)	9.11923908
4	DNA strand renaturation (GO:0000733)	9.10043205
5	GDP-mannose metabolic process (GO:0019673)	8.47099387
6	meiotic chromosome segregation (GO:0045132)	7.38272303
7	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	7.26537936
8	adenosine receptor signaling pathway (GO:0001973)	7.21805831
9	regulation of synapse structural plasticity (GO:0051823)	6.98103704
10	purinergic nucleotide receptor signaling pathway (GO:0035590)	6.86267499
11	peptidyl-glutamic acid carboxylation (GO:0017187)	6.62560120
12	protein carboxylation (GO:0018214)	6.62560120
13	rRNA methylation (GO:0031167)	6.44420616
14	positive regulation of protein kinase C signaling (GO:0090037)	6.33341951
15	behavioral response to nicotine (GO:0035095)	6.11273988
16	lens fiber cell differentiation (GO:0070306)	6.02243815
17	purine ribonucleotide transport (GO:0015868)	5.88566121
18	adenine nucleotide transport (GO:0051503)	5.84364145
19	sensory perception of taste (GO:0050909)	5.51952684
20	rRNA modification (GO:0000154)	5.41120615
21	detection of light stimulus involved in sensory perception (GO:0050962)	5.36615492
22	detection of light stimulus involved in visual perception (GO:0050908)	5.36615492
23	nucleoside transmembrane transport (GO:1901642)	5.31834040
24	response to ATP (GO:0033198)	5.29496864
25	transepithelial transport (GO:0070633)	5.27926780
26	urinary tract smooth muscle contraction (GO:0014848)	5.12638950
27	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.91429036
28	mitotic cell cycle arrest (GO:0071850)	4.84749252
29	purine nucleotide transport (GO:0015865)	4.84224582
30	purinergic receptor signaling pathway (GO:0035587)	4.83067393
31	neuromuscular synaptic transmission (GO:0007274)	4.76672562
32	melanin biosynthetic process (GO:0042438)	4.70518798
33	nucleotide transmembrane transport (GO:1901679)	4.66838825
34	peristalsis (GO:0030432)	4.58826070
35	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	4.51062261
36	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	4.51062261
37	regulation of cell aging (GO:0090342)	4.44615400
38	sex determination (GO:0007530)	4.21668829
39	melanin metabolic process (GO:0006582)	4.20153319
40	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	4.12084389
41	regulation of protein kinase A signaling (GO:0010738)	4.10724846
42	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	4.06636363
43	UV protection (GO:0009650)	3.98509701
44	sialylation (GO:0097503)	3.98415365
45	gonadal mesoderm development (GO:0007506)	3.97155354
46	grooming behavior (GO:0007625)	3.94643963
47	nucleotide-sugar biosynthetic process (GO:0009226)	3.91037518
48	nucleoside transport (GO:0015858)	3.88490679
49	sulfur amino acid catabolic process (GO:0000098)	3.81582614
50	secondary metabolite biosynthetic process (GO:0044550)	3.81391280
51	trivalent inorganic anion homeostasis (GO:0072506)	3.75461154
52	phosphate ion homeostasis (GO:0055062)	3.75461154
53	cellular anion homeostasis (GO:0030002)	3.69855017
54	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	3.67582973
55	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	3.67582973
56	nucleoside bisphosphate biosynthetic process (GO:0033866)	3.67582973
57	DNA replication checkpoint (GO:0000076)	3.62206673
58	positive regulation of heat generation (GO:0031652)	3.61255089
59	positive regulation of catecholamine secretion (GO:0033605)	3.59144690
60	estrogen biosynthetic process (GO:0006703)	3.58783697
61	protein import into peroxisome matrix (GO:0016558)	3.52933146
62	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:0007199	3.50956971
63	cilium or flagellum-dependent cell motility (GO:0001539)	3.47245440
64	regulation of phospholipid biosynthetic process (GO:0071071)	3.46834273
65	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.45356648
66	activation of adenylate cyclase activity (GO:0007190)	3.42741221
67	peptidyl-glutamic acid modification (GO:0018200)	3.40964991
68	histone phosphorylation (GO:0016572)	3.40535481
69	muscle fiber development (GO:0048747)	3.36937737
70	synaptic transmission, cholinergic (GO:0007271)	3.32106532
71	sphingosine metabolic process (GO:0006670)	3.31969949
72	phosphate ion transmembrane transport (GO:0035435)	3.30684361
73	proline metabolic process (GO:0006560)	3.25982355
74	phosphatidylglycerol biosynthetic process (GO:0006655)	3.22786109
75	sphingomyelin metabolic process (GO:0006684)	3.22410577
76	heme transport (GO:0015886)	3.13431791
77	iron coordination entity transport (GO:1901678)	3.06926200
78	eye photoreceptor cell development (GO:0042462)	3.02652885
79	diol metabolic process (GO:0034311)	3.01616051
80	tRNA modification (GO:0006400)	3.00286010
81	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.97887944
82	mitochondrial genome maintenance (GO:0000002)	2.96290725
83	positive regulation of adenylate cyclase activity (GO:0045762)	2.95751900
84	cell migration in hindbrain (GO:0021535)	2.93802413
85	phosphate ion transport (GO:0006817)	2.93167967
86	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.91770223
87	folic acid metabolic process (GO:0046655)	2.88771220
88	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	2.86603910
89	mitochondrion distribution (GO:0048311)	2.85837143
90	photoreceptor cell development (GO:0042461)	2.84123870
91	reciprocal DNA recombination (GO:0035825)	2.82404188
92	reciprocal meiotic recombination (GO:0007131)	2.82404188
93	alkaloid metabolic process (GO:0009820)	2.82138958
94	positive regulation of cyclase activity (GO:0031281)	2.81824859
95	positive regulation of type I interferon-mediated signaling pathway (GO:0060340)	2.81274732
96	regulation of protein kinase C signaling (GO:0090036)	2.80699819
97	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.79147200
98	response to gravity (GO:0009629)	2.77516267
99	cardiolipin metabolic process (GO:0032048)	2.76748849
100	respiratory chain complex IV assembly (GO:0008535)	2.75553740

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	STAT6_21828071_ChIP-Seq_BEAS2B_Human	4.54104125
2	VDR_21846776_ChIP-Seq_THP-1_Human	4.12367673
3	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	3.32278977
4	P68_20966046_ChIP-Seq_HELA_Human	3.29359704
5	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	3.02535260
6	LXR_22292898_ChIP-Seq_THP-1_Human	2.90497362
7	E2F1_20622854_ChIP-Seq_HELA_Human	2.72854863
8	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.67571760
9	XRN2_22483619_ChIP-Seq_HELA_Human	2.61935451
10	CTCF_27219007_Chip-Seq_Bcells_Human	2.60666330
11	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.56649431
12	BCL6_27268052_Chip-Seq_Bcells_Human	2.53955322
13	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	2.47482205
14	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.45772000
15	RARG_19884340_ChIP-ChIP_MEFs_Mouse	2.44574986
16	BCOR_27268052_Chip-Seq_Bcells_Human	2.44509265
17	MAF_26560356_Chip-Seq_TH2_Human	2.38355932
18	PHF8_20622854_ChIP-Seq_HELA_Human	2.32562288
19	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	2.18848308
20	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.11563571
21	RARB_24833708_ChIP-Seq_LIVER_Mouse	2.09164585
22	RXRA_24833708_ChIP-Seq_LIVER_Mouse	2.08186740
23	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.07460957
24	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	2.07425403
25	SMC4_20622854_ChIP-Seq_HELA_Human	1.98651929
26	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.96698882
27	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.92787525
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.92365174
29	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.87772151
30	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.85374621
31	VDR_24763502_ChIP-Seq_THP-1_Human	1.82675793
32	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.82071363
33	ERA_21632823_ChIP-Seq_H3396_Human	1.80751598
34	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.77589794
35	CTCF_20526341_ChIP-Seq_ESCs_Human	1.76542864
36	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.76177046
37	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.74860948
38	CTCF_21964334_Chip-Seq_Bcells_Human	1.73746642
39	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.65320229
40	MAF_26560356_Chip-Seq_TH1_Human	1.64902486
41	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.64767410
42	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.62237963
43	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.61824799
44	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.58152262
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.58104403
46	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.56977366
47	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.55054228
48	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.54532992
49	SA1_27219007_Chip-Seq_Bcells_Human	1.45284400
50	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.45226313
51	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44725557
52	P53_21459846_ChIP-Seq_SAOS-2_Human	1.43707693
53	CREB1_26743006_Chip-Seq_LNCaP_Human	1.42655197
54	* KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.42174840
55	TP53_22127205_ChIP-Seq_IMR90_Human	1.40897929
56	FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	1.39660661
57	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.39484877
58	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.37821983
59	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	1.37326176
60	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.37182558
61	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.33644275
62	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	1.32579480
63	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.32229561
64	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	1.30142187
65	KDM2B_26808549_Chip-Seq_DND41_Human	1.29505798
66	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.28830427
67	* TAF2_19829295_ChIP-Seq_ESCs_Human	1.28469300
68	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.28321236
69	OCT4_20526341_ChIP-Seq_ESCs_Human	1.27534775
70	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.25850525
71	P300_27268052_Chip-Seq_Bcells_Human	1.25154237
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.24681690
73	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.21938044
74	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.21734421
75	OCT4_19829295_ChIP-Seq_ESCs_Human	1.18498300
76	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.17627944
77	UTX_26944678_Chip-Seq_JUKART_Human	1.17486111
78	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.14616389
79	DCP1A_22483619_ChIP-Seq_HELA_Human	1.13580470
80	TP63_22573176_ChIP-Seq_HFKS_Human	1.13379460
81	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.12936933
82	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.11247177
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.10997892
84	GATA3_21867929_ChIP-Seq_CD8_Mouse	1.10377565
85	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.08957542
86	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07864169
87	SOX2_21211035_ChIP-Seq_LN229_Human	1.07087332
88	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.05947497
89	MYC_19829295_ChIP-Seq_ESCs_Human	1.05750508
90	RAC3_21632823_ChIP-Seq_H3396_Human	1.03662806
91	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.03623370
92	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.03050097
93	SETDB1_19884255_ChIP-Seq_MESCs_Mouse	1.02960036
94	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.00633585
95	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.99179581
96	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.98035772
97	GABP_19822575_ChIP-Seq_HepG2_Human	0.97790325
98	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97162170
99	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.96881877
100	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.96427349

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005171_absent_coat_pigmentation	7.43714594
2	MP0001986_abnormal_taste_sensitivity	6.78724874
3	MP0005423_abnormal_somatic_nervous	6.24578395
4	MP0005174_abnormal_tail_pigmentation	5.93118024
5	MP0003136_yellow_coat_color	5.91593021
6	MP0001188_hyperpigmentation	3.65749367
7	MP0001968_abnormal_touch/_nociception	3.56580994
8	MP0005409_darkened_coat_color	3.27680146
9	MP0002638_abnormal_pupillary_reflex	2.88594728
10	MP0005083_abnormal_biliary_tract	2.74586465
11	MP0002736_abnormal_nociception_after	2.71809154
12	MP0000751_myopathy	2.49143127
13	MP0008875_abnormal_xenobiotic_pharmacok	2.27695337
14	MP0001756_abnormal_urination	2.20154483
15	MP0000015_abnormal_ear_pigmentation	2.18277572
16	MP0003806_abnormal_nucleotide_metabolis	2.16293771
17	MP0001502_abnormal_circadian_rhythm	2.15567584
18	MP0002735_abnormal_chemical_nociception	2.03338769
19	MP0004381_abnormal_hair_follicle	1.95117367
20	MP0000538_abnormal_urinary_bladder	1.87911634
21	MP0010386_abnormal_urinary_bladder	1.84655082
22	MP0000750_abnormal_muscle_regeneration	1.72520313
23	MP0000013_abnormal_adipose_tissue	1.43448212
24	MP0002160_abnormal_reproductive_system	1.43004560
25	MP0005551_abnormal_eye_electrophysiolog	1.38707499
26	MP0001661_extended_life_span	1.38102126
27	MP0005330_cardiomyopathy	1.29951012
28	MP0004043_abnormal_pH_regulation	1.28167940
29	MP0005332_abnormal_amino_acid	1.27549765
30	MP0004130_abnormal_muscle_cell	1.21165175
31	MP0005410_abnormal_fertilization	1.16317030
32	MP0001664_abnormal_digestion	1.10768411
33	MP0001765_abnormal_ion_homeostasis	1.09380179
34	MP0004019_abnormal_vitamin_homeostasis	1.08812279
35	MP0003453_abnormal_keratinocyte_physiol	1.04159054
36	MP0000747_muscle_weakness	1.03788922
37	MP0005365_abnormal_bile_salt	1.00815432
38	MP0000003_abnormal_adipose_tissue	0.97408373
39	MP0003111_abnormal_nucleus_morphology	0.92514751
40	MP0002254_reproductive_system_inflammat	0.91893460
41	MP0005084_abnormal_gallbladder_morpholo	0.91319170
42	MP0001970_abnormal_pain_threshold	0.91062905
43	MP0003195_calcinosis	0.89861517
44	MP0005377_hearing/vestibular/ear_phenot	0.85277752
45	MP0003878_abnormal_ear_physiology	0.85277752
46	MP0002909_abnormal_adrenal_gland	0.82265751
47	MP0005584_abnormal_enzyme/coenzyme_acti	0.80252720
48	MP0001958_emphysema	0.76751875
49	MP0003137_abnormal_impulse_conducting	0.76738144
50	MP0005253_abnormal_eye_physiology	0.75676739
51	MP0005501_abnormal_skin_physiology	0.75541210
52	MP0000358_abnormal_cell_content/	0.71229782
53	MP0001324_abnormal_eye_pigmentation	0.70234876
54	MP0001905_abnormal_dopamine_level	0.66876173
55	MP0002075_abnormal_coat/hair_pigmentati	0.66213265
56	MP0006276_abnormal_autonomic_nervous	0.64233221
57	MP0008789_abnormal_olfactory_epithelium	0.61727801
58	MP0002928_abnormal_bile_duct	0.61159685
59	MP0000470_abnormal_stomach_morphology	0.59884182
60	MP0010771_integument_phenotype	0.59760185
61	MP0002249_abnormal_larynx_morphology	0.57887161
62	MP0009384_cardiac_valve_regurgitation	0.55088267
63	MP0003091_abnormal_cell_migration	0.54922373
64	MP0004215_abnormal_myocardial_fiber	0.54216307
65	MP0003693_abnormal_embryo_hatching	0.54149635
66	MP0003635_abnormal_synaptic_transmissio	0.54007324
67	MP0000026_abnormal_inner_ear	0.53814979
68	MP0001919_abnormal_reproductive_system	0.52296272
69	MP0000367_abnormal_coat/_hair	0.51758092
70	MP0005085_abnormal_gallbladder_physiolo	0.50194756
71	MP0002822_catalepsy	0.49882132
72	MP0005389_reproductive_system_phenotype	0.49873612
73	MP0009053_abnormal_anal_canal	0.48964862
74	MP0003879_abnormal_hair_cell	0.48947748
75	MP0005076_abnormal_cell_differentiation	0.48080391
76	MP0009643_abnormal_urine_homeostasis	0.47222317
77	MP0005257_abnormal_intraocular_pressure	0.47025071
78	MP0002067_abnormal_sensory_capabilities	0.45438750
79	MP0004145_abnormal_muscle_electrophysio	0.44991523
80	MP0003880_abnormal_central_pattern	0.43304951
81	MP0002272_abnormal_nervous_system	0.43245215
82	MP0003705_abnormal_hypodermis_morpholog	0.43117612
83	MP0001348_abnormal_lacrimal_gland	0.42220781
84	MP0001186_pigmentation_phenotype	0.41887877
85	MP0002063_abnormal_learning/memory/cond	0.39833067
86	MP0003632_abnormal_nervous_system	0.39810879
87	MP0002572_abnormal_emotion/affect_behav	0.39228092
88	MP0003448_altered_tumor_morphology	0.37846056
89	MP0004197_abnormal_fetal_growth/weight/	0.37795553
90	MP0000759_abnormal_skeletal_muscle	0.37202454
91	MP0005394_taste/olfaction_phenotype	0.37138326
92	MP0005499_abnormal_olfactory_system	0.37138326
93	MP0008874_decreased_physiological_sensi	0.36922094
94	MP0003698_abnormal_male_reproductive	0.36037997
95	MP0002136_abnormal_kidney_physiology	0.35831249
96	MP0009931_abnormal_skin_appearance	0.35792229
97	MP0009745_abnormal_behavioral_response	0.35348658
98	MP0002734_abnormal_mechanical_nocicepti	0.34401088
99	MP0001270_distended_abdomen	0.34239004
100	MP0000778_abnormal_nervous_system	0.34051260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Rib fusion (HP:0000902)	6.48969628
2	Testicular atrophy (HP:0000029)	6.25830366
3	Popliteal pterygium (HP:0009756)	5.66427625
4	Attenuation of retinal blood vessels (HP:0007843)	5.54363283
5	Thin bony cortex (HP:0002753)	5.46946192
6	Poikiloderma (HP:0001029)	5.31406109
7	Rectovaginal fistula (HP:0000143)	5.22704116
8	Rectal fistula (HP:0100590)	5.22704116
9	Akinesia (HP:0002304)	4.95090521
10	Intestinal fistula (HP:0100819)	4.91724568
11	Aplasia of the musculature (HP:0100854)	4.88553375
12	Facial hemangioma (HP:0000329)	4.74971551
13	Vaginal fistula (HP:0004320)	4.73493228
14	Fetal akinesia sequence (HP:0001989)	4.65435051
15	Annular pancreas (HP:0001734)	4.50038524
16	Congenital stationary night blindness (HP:0007642)	4.42162474
17	Dyschromatopsia (HP:0007641)	4.41565595
18	Ulnar bowing (HP:0003031)	4.30461292
19	Amniotic constriction ring (HP:0009775)	4.19293047
20	Abnormality of placental membranes (HP:0011409)	4.19293047
21	Coronal craniosynostosis (HP:0004440)	4.15343924
22	Turricephaly (HP:0000262)	4.03797479
23	Abnormality of the intrinsic pathway (HP:0010989)	4.02334240
24	Delayed epiphyseal ossification (HP:0002663)	4.02162475
25	Facial diplegia (HP:0001349)	4.00350700
26	Bony spicule pigmentary retinopathy (HP:0007737)	3.98991261
27	Squamous cell carcinoma (HP:0002860)	3.79430171
28	Enlarged epiphyses (HP:0010580)	3.78733611
29	Chorioretinal atrophy (HP:0000533)	3.74896595
30	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.72269661
31	Hemorrhage of the eye (HP:0011885)	3.64391452
32	Prolonged partial thromboplastin time (HP:0003645)	3.59417229
33	Abnormality of the costochondral junction (HP:0000919)	3.45220174
34	Mesangial abnormality (HP:0001966)	3.33457485
35	Joint hemorrhage (HP:0005261)	3.33165374
36	Myotonia (HP:0002486)	3.30912841
37	Short chin (HP:0000331)	3.26770768
38	Patellar aplasia (HP:0006443)	3.24955529
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.21818572
40	Widely patent fontanelles and sutures (HP:0004492)	3.08267697
41	Capillary hemangiomas (HP:0005306)	3.08234505
42	Hypophosphatemic rickets (HP:0004912)	3.07832625
43	Aplasia/Hypoplasia of the patella (HP:0006498)	3.03369225
44	Decreased central vision (HP:0007663)	3.00501244
45	Abnormal albumin level (HP:0012116)	2.93878658
46	Hypoalbuminemia (HP:0003073)	2.93878658
47	Anteriorly placed anus (HP:0001545)	2.92256365
48	Atrioventricular block (HP:0001678)	2.84675500
49	Type 2 muscle fiber atrophy (HP:0003554)	2.82488274
50	Malignant hyperthermia (HP:0002047)	2.81024951
51	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.80211511
52	Choroideremia (HP:0001139)	2.80070563
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.73891630
54	Renal Fanconi syndrome (HP:0001994)	2.70308359
55	Pterygium (HP:0001059)	2.68043104
56	Thin ribs (HP:0000883)	2.64251964
57	Flat occiput (HP:0005469)	2.62250440
58	Increased hepatocellular lipid droplets (HP:0006565)	2.61239090
59	Birth length less than 3rd percentile (HP:0003561)	2.60144937
60	Neonatal respiratory distress (HP:0002643)	2.52777776
61	Pendular nystagmus (HP:0012043)	2.52372440
62	Muscle fiber atrophy (HP:0100295)	2.49214103
63	Lipid accumulation in hepatocytes (HP:0006561)	2.49060307
64	Reduced antithrombin III activity (HP:0001976)	2.45181468
65	Joint stiffness (HP:0001387)	2.38614949
66	Absent thumb (HP:0009777)	2.37792752
67	Bowing of the arm (HP:0006488)	2.37773745
68	Bowed forearm bones (HP:0003956)	2.37773745
69	Choanal stenosis (HP:0000452)	2.36720998
70	Fatigable weakness (HP:0003473)	2.35680299
71	Abnormality of the neuromuscular junction (HP:0003398)	2.35680299
72	Short humerus (HP:0005792)	2.34907430
73	Male infertility (HP:0003251)	2.32301407
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.30481653
75	Increased number of teeth (HP:0011069)	2.25805296
76	Narrow nasal bridge (HP:0000446)	2.24548441
77	Abnormal epiphyseal ossification (HP:0010656)	2.22576598
78	Diminished movement (HP:0002374)	2.15179122
79	Zonular cataract (HP:0010920)	2.14834713
80	Cystic hygroma (HP:0000476)	2.12770182
81	Premature graying of hair (HP:0002216)	2.10506721
82	Aplasia/hypoplasia of the humerus (HP:0006507)	2.08549206
83	Basal cell carcinoma (HP:0002671)	2.08291879
84	Small hand (HP:0200055)	2.05241770
85	Absent radius (HP:0003974)	2.01831646
86	Breast hypoplasia (HP:0003187)	2.01531158
87	Neonatal onset (HP:0003623)	2.00839733
88	Increased intramyocellular lipid droplets (HP:0012240)	1.96866812
89	Abnormal drinking behavior (HP:0030082)	1.92033960
90	Polydipsia (HP:0001959)	1.92033960
91	Myopathic facies (HP:0002058)	1.89959993
92	Absent forearm bone (HP:0003953)	1.87300448
93	Aplasia involving forearm bones (HP:0009822)	1.87300448
94	Heart block (HP:0012722)	1.85780389
95	Metaphyseal irregularity (HP:0003025)	1.83684994
96	Increased muscle lipid content (HP:0009058)	1.83036886
97	Wide cranial sutures (HP:0010537)	1.79882294
98	Short thumb (HP:0009778)	1.79576871
99	Homocystinuria (HP:0002156)	1.77822254
100	Abnormality of homocysteine metabolism (HP:0010919)	1.77822254

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAPK15	9.80078815
2	WNK4	6.19598401
3	MUSK	3.53158869
4	TLK1	3.49562973
5	BLK	3.32848905
6	TESK2	1.91877470
7	GRK6	1.90865559
8	ADRBK2	1.87467159
9	ACVR1B	1.79931029
10	WNK1	1.74863143
11	STK16	1.71954541
12	ZAK	1.71622294
13	CCNB1	1.49637378
14	MST1R	1.45353077
15	DYRK1B	1.41784408
16	ADRBK1	1.40659579
17	SIK2	1.40201171
18	MAP2K6	1.29742432
19	BMPR1B	1.27873235
20	PDK2	1.25586479
21	ERN1	1.15905513
22	STK39	1.15621009
23	CASK	1.10350490
24	SIK1	1.09081637
25	CDK15	1.08866802
26	PDPK1	1.07047544
27	CDK11A	1.04965852
28	CDK18	1.02250145
29	NEK2	1.00843865
30	MET	0.93428392
31	TRIM28	0.90105959
32	ZAP70	0.85488783
33	DAPK2	0.83963862
34	MAP3K9	0.83924187
35	CSNK1D	0.82017129
36	TRIB3	0.81151871
37	PIM2	0.80600861
38	PRKD2	0.78492002
39	CDK14	0.76677290
40	MAP2K3	0.74797343
41	PRKD3	0.73283176
42	FRK	0.68928497
43	CDK4	0.68792395
44	CDK6	0.68711516
45	MARK1	0.65866590
46	MAPK12	0.65211901
47	TBK1	0.65201616
48	RPS6KA2	0.64795034
49	RPS6KA5	0.63982796
50	BMX	0.63476200
51	PRKD1	0.62916523
52	IRAK2	0.62048147
53	PRKAA1	0.61702435
54	ARAF	0.58680654
55	GRK1	0.57167244
56	DYRK2	0.56500367
57	TGFBR1	0.53422638
58	CHEK2	0.53089270
59	MAPK11	0.52222261
60	PIK3CG	0.51742874
61	SGK223	0.50493026
62	SGK494	0.50493026
63	RPS6KA6	0.47835768
64	ATR	0.46994735
65	EPHB2	0.46687763
66	MAPK8	0.46610924
67	CSNK1G3	0.44104462
68	CSNK1A1L	0.42464135
69	AURKA	0.42242876
70	OXSR1	0.42204815
71	PAK6	0.41620149
72	PRKCG	0.40645305
73	CSK	0.39931521
74	PAK1	0.37818580
75	PLK1	0.34913266
76	MELK	0.34857480
77	CDK5	0.34155241
78	MTOR	0.33193387
79	PHKG1	0.32012119
80	PHKG2	0.32012119
81	RPS6KL1	0.31884490
82	RPS6KC1	0.31884490
83	PRKACA	0.31421374
84	MAPK13	0.29400695
85	ERBB2	0.28242163
86	NEK6	0.28077967
87	CSNK1G2	0.28002968
88	STK38	0.24672721
89	MAP2K4	0.23972470
90	PINK1	0.23955254
91	MAP2K7	0.23908321
92	PRKG1	0.22844195
93	DAPK3	0.22262930
94	ROCK1	0.21722557
95	PRKACG	0.21434806
96	PRKCA	0.21161100
97	STK38L	0.21094225
98	AKT3	0.20694320
99	CDK1	0.20290650
100	PKN1	0.20119298

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	7.41890953
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	6.47472183
3	Sulfur relay system_Homo sapiens_hsa04122	6.12082775
4	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.28001418
5	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.12442034
6	Fructose and mannose metabolism_Homo sapiens_hsa00051	2.90402351
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.40986229
8	Glycosaminoglycan degradation_Homo sapiens_hsa00531	2.28087246
9	Circadian rhythm_Homo sapiens_hsa04710	1.95457427
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95203672
11	Taste transduction_Homo sapiens_hsa04742	1.92551170
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.88645472
13	Nicotine addiction_Homo sapiens_hsa05033	1.76865509
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.69321557
15	Sphingolipid metabolism_Homo sapiens_hsa00600	1.69186457
16	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.67402244
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.49016429
18	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.43434592
19	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.42548915
20	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.28313017
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.23701327
22	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.04553871
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.02768329
24	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.99726022
25	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.98311080
26	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.97353279
27	Pyruvate metabolism_Homo sapiens_hsa00620	0.82064486
28	Arginine biosynthesis_Homo sapiens_hsa00220	0.80349240
29	Calcium signaling pathway_Homo sapiens_hsa04020	0.79410405
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.78673492
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.77137290
32	Phenylalanine metabolism_Homo sapiens_hsa00360	0.74454003
33	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72623843
34	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71805578
35	Cocaine addiction_Homo sapiens_hsa05030	0.71538624
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.66713732
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.66598355
38	Phototransduction_Homo sapiens_hsa04744	0.66410150
39	Hippo signaling pathway_Homo sapiens_hsa04390	0.63337958
40	RNA polymerase_Homo sapiens_hsa03020	0.62543669
41	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58534586
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.58284053
43	Alcoholism_Homo sapiens_hsa05034	0.56701741
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.56081438
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55658138
46	ABC transporters_Homo sapiens_hsa02010	0.55640548
47	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.55637978
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55177976
49	Glutamatergic synapse_Homo sapiens_hsa04724	0.50310422
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49053020
51	Morphine addiction_Homo sapiens_hsa05032	0.47482612
52	Basal cell carcinoma_Homo sapiens_hsa05217	0.47134489
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45984845
54	Bile secretion_Homo sapiens_hsa04976	0.45685814
55	Lysosome_Homo sapiens_hsa04142	0.45626391
56	Sulfur metabolism_Homo sapiens_hsa00920	0.41536502
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.41530944
58	Lysine degradation_Homo sapiens_hsa00310	0.40704964
59	Basal transcription factors_Homo sapiens_hsa03022	0.39418635
60	Metabolic pathways_Homo sapiens_hsa01100	0.38924060
61	Melanogenesis_Homo sapiens_hsa04916	0.38153569
62	Non-homologous end-joining_Homo sapiens_hsa03450	0.36027134
63	Cholinergic synapse_Homo sapiens_hsa04725	0.35127058
64	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35074973
65	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.34961730
66	Fatty acid degradation_Homo sapiens_hsa00071	0.33552786
67	GABAergic synapse_Homo sapiens_hsa04727	0.31793793
68	Circadian entrainment_Homo sapiens_hsa04713	0.31489225
69	Peroxisome_Homo sapiens_hsa04146	0.30008289
70	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.29342926
71	Linoleic acid metabolism_Homo sapiens_hsa00591	0.28047680
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.26079538
73	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26039864
74	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.25961283
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.25744614
76	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.25202858
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25172015
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24537757
79	Gap junction_Homo sapiens_hsa04540	0.24101347
80	Retinol metabolism_Homo sapiens_hsa00830	0.24041155
81	Homologous recombination_Homo sapiens_hsa03440	0.23097563
82	Amphetamine addiction_Homo sapiens_hsa05031	0.20846023
83	Endocytosis_Homo sapiens_hsa04144	0.20262240
84	Serotonergic synapse_Homo sapiens_hsa04726	0.19748698
85	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.18950787
86	Histidine metabolism_Homo sapiens_hsa00340	0.18446039
87	Tryptophan metabolism_Homo sapiens_hsa00380	0.17690559
88	Base excision repair_Homo sapiens_hsa03410	0.16921912
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.16671706
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.16426838
91	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.15805806
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.14363801
93	Mineral absorption_Homo sapiens_hsa04978	0.13963243
94	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.13414835
95	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.11428278
96	mTOR signaling pathway_Homo sapiens_hsa04150	0.11298158
97	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.09930351
98	Other glycan degradation_Homo sapiens_hsa00511	0.08919194
99	Pyrimidine metabolism_Homo sapiens_hsa00240	0.07595689
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.06761279

FOXD4L4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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