FOXD4L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular response to ATP (GO:0071318)9.80341461
2negative regulation of cell aging (GO:0090344)9.12799999
3regulation of skeletal muscle contraction (GO:0014819)9.11923908
4DNA strand renaturation (GO:0000733)9.10043205
5GDP-mannose metabolic process (GO:0019673)8.47099387
6meiotic chromosome segregation (GO:0045132)7.38272303
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)7.26537936
8adenosine receptor signaling pathway (GO:0001973)7.21805831
9regulation of synapse structural plasticity (GO:0051823)6.98103704
10purinergic nucleotide receptor signaling pathway (GO:0035590)6.86267499
11peptidyl-glutamic acid carboxylation (GO:0017187)6.62560120
12protein carboxylation (GO:0018214)6.62560120
13rRNA methylation (GO:0031167)6.44420616
14positive regulation of protein kinase C signaling (GO:0090037)6.33341951
15behavioral response to nicotine (GO:0035095)6.11273988
16lens fiber cell differentiation (GO:0070306)6.02243815
17purine ribonucleotide transport (GO:0015868)5.88566121
18adenine nucleotide transport (GO:0051503)5.84364145
19sensory perception of taste (GO:0050909)5.51952684
20rRNA modification (GO:0000154)5.41120615
21detection of light stimulus involved in sensory perception (GO:0050962)5.36615492
22detection of light stimulus involved in visual perception (GO:0050908)5.36615492
23nucleoside transmembrane transport (GO:1901642)5.31834040
24response to ATP (GO:0033198)5.29496864
25transepithelial transport (GO:0070633)5.27926780
26urinary tract smooth muscle contraction (GO:0014848)5.12638950
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.91429036
28mitotic cell cycle arrest (GO:0071850)4.84749252
29purine nucleotide transport (GO:0015865)4.84224582
30purinergic receptor signaling pathway (GO:0035587)4.83067393
31neuromuscular synaptic transmission (GO:0007274)4.76672562
32melanin biosynthetic process (GO:0042438)4.70518798
33nucleotide transmembrane transport (GO:1901679)4.66838825
34peristalsis (GO:0030432)4.58826070
35purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.51062261
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.51062261
37regulation of cell aging (GO:0090342)4.44615400
38sex determination (GO:0007530)4.21668829
39melanin metabolic process (GO:0006582)4.20153319
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.12084389
41regulation of protein kinase A signaling (GO:0010738)4.10724846
42G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.06636363
43UV protection (GO:0009650)3.98509701
44sialylation (GO:0097503)3.98415365
45gonadal mesoderm development (GO:0007506)3.97155354
46grooming behavior (GO:0007625)3.94643963
47nucleotide-sugar biosynthetic process (GO:0009226)3.91037518
48nucleoside transport (GO:0015858)3.88490679
49sulfur amino acid catabolic process (GO:0000098)3.81582614
50secondary metabolite biosynthetic process (GO:0044550)3.81391280
51trivalent inorganic anion homeostasis (GO:0072506)3.75461154
52phosphate ion homeostasis (GO:0055062)3.75461154
53cellular anion homeostasis (GO:0030002)3.69855017
54purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.67582973
55ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.67582973
56nucleoside bisphosphate biosynthetic process (GO:0033866)3.67582973
57DNA replication checkpoint (GO:0000076)3.62206673
58positive regulation of heat generation (GO:0031652)3.61255089
59positive regulation of catecholamine secretion (GO:0033605)3.59144690
60estrogen biosynthetic process (GO:0006703)3.58783697
61protein import into peroxisome matrix (GO:0016558)3.52933146
62G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.50956971
63cilium or flagellum-dependent cell motility (GO:0001539)3.47245440
64regulation of phospholipid biosynthetic process (GO:0071071)3.46834273
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.45356648
66activation of adenylate cyclase activity (GO:0007190)3.42741221
67peptidyl-glutamic acid modification (GO:0018200)3.40964991
68histone phosphorylation (GO:0016572)3.40535481
69muscle fiber development (GO:0048747)3.36937737
70synaptic transmission, cholinergic (GO:0007271)3.32106532
71sphingosine metabolic process (GO:0006670)3.31969949
72phosphate ion transmembrane transport (GO:0035435)3.30684361
73proline metabolic process (GO:0006560)3.25982355
74phosphatidylglycerol biosynthetic process (GO:0006655)3.22786109
75sphingomyelin metabolic process (GO:0006684)3.22410577
76heme transport (GO:0015886)3.13431791
77iron coordination entity transport (GO:1901678)3.06926200
78eye photoreceptor cell development (GO:0042462)3.02652885
79diol metabolic process (GO:0034311)3.01616051
80tRNA modification (GO:0006400)3.00286010
81triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97887944
82mitochondrial genome maintenance (GO:0000002)2.96290725
83positive regulation of adenylate cyclase activity (GO:0045762)2.95751900
84cell migration in hindbrain (GO:0021535)2.93802413
85phosphate ion transport (GO:0006817)2.93167967
86phosphatidylethanolamine biosynthetic process (GO:0006646)2.91770223
87folic acid metabolic process (GO:0046655)2.88771220
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.86603910
89mitochondrion distribution (GO:0048311)2.85837143
90photoreceptor cell development (GO:0042461)2.84123870
91reciprocal DNA recombination (GO:0035825)2.82404188
92reciprocal meiotic recombination (GO:0007131)2.82404188
93alkaloid metabolic process (GO:0009820)2.82138958
94positive regulation of cyclase activity (GO:0031281)2.81824859
95positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.81274732
96regulation of protein kinase C signaling (GO:0090036)2.80699819
97regulation of nuclear cell cycle DNA replication (GO:0033262)2.79147200
98response to gravity (GO:0009629)2.77516267
99cardiolipin metabolic process (GO:0032048)2.76748849
100respiratory chain complex IV assembly (GO:0008535)2.75553740

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.54104125
2VDR_21846776_ChIP-Seq_THP-1_Human4.12367673
3CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.32278977
4P68_20966046_ChIP-Seq_HELA_Human3.29359704
5TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.02535260
6LXR_22292898_ChIP-Seq_THP-1_Human2.90497362
7E2F1_20622854_ChIP-Seq_HELA_Human2.72854863
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67571760
9XRN2_22483619_ChIP-Seq_HELA_Human2.61935451
10CTCF_27219007_Chip-Seq_Bcells_Human2.60666330
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.56649431
12BCL6_27268052_Chip-Seq_Bcells_Human2.53955322
13MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.47482205
14IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45772000
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44574986
16BCOR_27268052_Chip-Seq_Bcells_Human2.44509265
17MAF_26560356_Chip-Seq_TH2_Human2.38355932
18PHF8_20622854_ChIP-Seq_HELA_Human2.32562288
19SMAD2/3_21741376_ChIP-Seq_ESCs_Human2.18848308
20TET1_21451524_ChIP-Seq_MESCs_Mouse2.11563571
21RARB_24833708_ChIP-Seq_LIVER_Mouse2.09164585
22RXRA_24833708_ChIP-Seq_LIVER_Mouse2.08186740
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07460957
24DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07425403
25SMC4_20622854_ChIP-Seq_HELA_Human1.98651929
26RARA_24833708_ChIP-Seq_LIVER_Mouse1.96698882
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.92787525
28RACK7_27058665_Chip-Seq_MCF-7_Human1.92365174
29FOXP1_21924763_ChIP-Seq_HESCs_Human1.87772151
30DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.85374621
31VDR_24763502_ChIP-Seq_THP-1_Human1.82675793
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.82071363
33ERA_21632823_ChIP-Seq_H3396_Human1.80751598
34SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77589794
35CTCF_20526341_ChIP-Seq_ESCs_Human1.76542864
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.76177046
37CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.74860948
38CTCF_21964334_Chip-Seq_Bcells_Human1.73746642
39SA1_27219007_Chip-Seq_ERYTHROID_Human1.65320229
40MAF_26560356_Chip-Seq_TH1_Human1.64902486
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64767410
42SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62237963
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.61824799
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.58152262
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58104403
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.56977366
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.55054228
48CTCF_21964334_ChIP-Seq_BJAB-B_Human1.54532992
49SA1_27219007_Chip-Seq_Bcells_Human1.45284400
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45226313
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.44725557
52P53_21459846_ChIP-Seq_SAOS-2_Human1.43707693
53CREB1_26743006_Chip-Seq_LNCaP_Human1.42655197
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42174840
55TP53_22127205_ChIP-Seq_IMR90_Human1.40897929
56FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39660661
57ETS1_21867929_ChIP-Seq_TH2_Mouse1.39484877
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.37821983
59NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.37326176
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37182558
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33644275
62JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.32579480
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.32229561
64TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.30142187
65KDM2B_26808549_Chip-Seq_DND41_Human1.29505798
66PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28830427
67* TAF2_19829295_ChIP-Seq_ESCs_Human1.28469300
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28321236
69OCT4_20526341_ChIP-Seq_ESCs_Human1.27534775
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25850525
71P300_27268052_Chip-Seq_Bcells_Human1.25154237
72NANOG_20526341_ChIP-Seq_ESCs_Human1.24681690
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21938044
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21734421
75OCT4_19829295_ChIP-Seq_ESCs_Human1.18498300
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.17627944
77UTX_26944678_Chip-Seq_JUKART_Human1.17486111
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14616389
79DCP1A_22483619_ChIP-Seq_HELA_Human1.13580470
80TP63_22573176_ChIP-Seq_HFKS_Human1.13379460
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.12936933
82MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11247177
83EZH2_27294783_Chip-Seq_ESCs_Mouse1.10997892
84GATA3_21867929_ChIP-Seq_CD8_Mouse1.10377565
85PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08957542
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.07864169
87SOX2_21211035_ChIP-Seq_LN229_Human1.07087332
88E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05947497
89MYC_19829295_ChIP-Seq_ESCs_Human1.05750508
90RAC3_21632823_ChIP-Seq_H3396_Human1.03662806
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03623370
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.03050097
93SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02960036
94UBF1/2_26484160_Chip-Seq_HMECs_Human1.00633585
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99179581
96ESR2_21235772_ChIP-Seq_MCF-7_Human0.98035772
97GABP_19822575_ChIP-Seq_HepG2_Human0.97790325
98EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97162170
99SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96881877
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.96427349

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.43714594
2MP0001986_abnormal_taste_sensitivity6.78724874
3MP0005423_abnormal_somatic_nervous6.24578395
4MP0005174_abnormal_tail_pigmentation5.93118024
5MP0003136_yellow_coat_color5.91593021
6MP0001188_hyperpigmentation3.65749367
7MP0001968_abnormal_touch/_nociception3.56580994
8MP0005409_darkened_coat_color3.27680146
9MP0002638_abnormal_pupillary_reflex2.88594728
10MP0005083_abnormal_biliary_tract2.74586465
11MP0002736_abnormal_nociception_after2.71809154
12MP0000751_myopathy2.49143127
13MP0008875_abnormal_xenobiotic_pharmacok2.27695337
14MP0001756_abnormal_urination2.20154483
15MP0000015_abnormal_ear_pigmentation2.18277572
16MP0003806_abnormal_nucleotide_metabolis2.16293771
17MP0001502_abnormal_circadian_rhythm2.15567584
18MP0002735_abnormal_chemical_nociception2.03338769
19MP0004381_abnormal_hair_follicle1.95117367
20MP0000538_abnormal_urinary_bladder1.87911634
21MP0010386_abnormal_urinary_bladder1.84655082
22MP0000750_abnormal_muscle_regeneration1.72520313
23MP0000013_abnormal_adipose_tissue1.43448212
24MP0002160_abnormal_reproductive_system1.43004560
25MP0005551_abnormal_eye_electrophysiolog1.38707499
26MP0001661_extended_life_span1.38102126
27MP0005330_cardiomyopathy1.29951012
28MP0004043_abnormal_pH_regulation1.28167940
29MP0005332_abnormal_amino_acid1.27549765
30MP0004130_abnormal_muscle_cell1.21165175
31MP0005410_abnormal_fertilization1.16317030
32MP0001664_abnormal_digestion1.10768411
33MP0001765_abnormal_ion_homeostasis1.09380179
34MP0004019_abnormal_vitamin_homeostasis1.08812279
35MP0003453_abnormal_keratinocyte_physiol1.04159054
36MP0000747_muscle_weakness1.03788922
37MP0005365_abnormal_bile_salt1.00815432
38MP0000003_abnormal_adipose_tissue0.97408373
39MP0003111_abnormal_nucleus_morphology0.92514751
40MP0002254_reproductive_system_inflammat0.91893460
41MP0005084_abnormal_gallbladder_morpholo0.91319170
42MP0001970_abnormal_pain_threshold0.91062905
43MP0003195_calcinosis0.89861517
44MP0005377_hearing/vestibular/ear_phenot0.85277752
45MP0003878_abnormal_ear_physiology0.85277752
46MP0002909_abnormal_adrenal_gland0.82265751
47MP0005584_abnormal_enzyme/coenzyme_acti0.80252720
48MP0001958_emphysema0.76751875
49MP0003137_abnormal_impulse_conducting0.76738144
50MP0005253_abnormal_eye_physiology0.75676739
51MP0005501_abnormal_skin_physiology0.75541210
52MP0000358_abnormal_cell_content/0.71229782
53MP0001324_abnormal_eye_pigmentation0.70234876
54MP0001905_abnormal_dopamine_level0.66876173
55MP0002075_abnormal_coat/hair_pigmentati0.66213265
56MP0006276_abnormal_autonomic_nervous0.64233221
57MP0008789_abnormal_olfactory_epithelium0.61727801
58MP0002928_abnormal_bile_duct0.61159685
59MP0000470_abnormal_stomach_morphology0.59884182
60MP0010771_integument_phenotype0.59760185
61MP0002249_abnormal_larynx_morphology0.57887161
62MP0009384_cardiac_valve_regurgitation0.55088267
63MP0003091_abnormal_cell_migration0.54922373
64MP0004215_abnormal_myocardial_fiber0.54216307
65MP0003693_abnormal_embryo_hatching0.54149635
66MP0003635_abnormal_synaptic_transmissio0.54007324
67MP0000026_abnormal_inner_ear0.53814979
68MP0001919_abnormal_reproductive_system0.52296272
69MP0000367_abnormal_coat/_hair0.51758092
70MP0005085_abnormal_gallbladder_physiolo0.50194756
71MP0002822_catalepsy0.49882132
72MP0005389_reproductive_system_phenotype0.49873612
73MP0009053_abnormal_anal_canal0.48964862
74MP0003879_abnormal_hair_cell0.48947748
75MP0005076_abnormal_cell_differentiation0.48080391
76MP0009643_abnormal_urine_homeostasis0.47222317
77MP0005257_abnormal_intraocular_pressure0.47025071
78MP0002067_abnormal_sensory_capabilities0.45438750
79MP0004145_abnormal_muscle_electrophysio0.44991523
80MP0003880_abnormal_central_pattern0.43304951
81MP0002272_abnormal_nervous_system0.43245215
82MP0003705_abnormal_hypodermis_morpholog0.43117612
83MP0001348_abnormal_lacrimal_gland0.42220781
84MP0001186_pigmentation_phenotype0.41887877
85MP0002063_abnormal_learning/memory/cond0.39833067
86MP0003632_abnormal_nervous_system0.39810879
87MP0002572_abnormal_emotion/affect_behav0.39228092
88MP0003448_altered_tumor_morphology0.37846056
89MP0004197_abnormal_fetal_growth/weight/0.37795553
90MP0000759_abnormal_skeletal_muscle0.37202454
91MP0005394_taste/olfaction_phenotype0.37138326
92MP0005499_abnormal_olfactory_system0.37138326
93MP0008874_decreased_physiological_sensi0.36922094
94MP0003698_abnormal_male_reproductive0.36037997
95MP0002136_abnormal_kidney_physiology0.35831249
96MP0009931_abnormal_skin_appearance0.35792229
97MP0009745_abnormal_behavioral_response0.35348658
98MP0002734_abnormal_mechanical_nocicepti0.34401088
99MP0001270_distended_abdomen0.34239004
100MP0000778_abnormal_nervous_system0.34051260

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)6.48969628
2Testicular atrophy (HP:0000029)6.25830366
3Popliteal pterygium (HP:0009756)5.66427625
4Attenuation of retinal blood vessels (HP:0007843)5.54363283
5Thin bony cortex (HP:0002753)5.46946192
6Poikiloderma (HP:0001029)5.31406109
7Rectovaginal fistula (HP:0000143)5.22704116
8Rectal fistula (HP:0100590)5.22704116
9Akinesia (HP:0002304)4.95090521
10Intestinal fistula (HP:0100819)4.91724568
11Aplasia of the musculature (HP:0100854)4.88553375
12Facial hemangioma (HP:0000329)4.74971551
13Vaginal fistula (HP:0004320)4.73493228
14Fetal akinesia sequence (HP:0001989)4.65435051
15Annular pancreas (HP:0001734)4.50038524
16Congenital stationary night blindness (HP:0007642)4.42162474
17Dyschromatopsia (HP:0007641)4.41565595
18Ulnar bowing (HP:0003031)4.30461292
19Amniotic constriction ring (HP:0009775)4.19293047
20Abnormality of placental membranes (HP:0011409)4.19293047
21Coronal craniosynostosis (HP:0004440)4.15343924
22Turricephaly (HP:0000262)4.03797479
23Abnormality of the intrinsic pathway (HP:0010989)4.02334240
24Delayed epiphyseal ossification (HP:0002663)4.02162475
25Facial diplegia (HP:0001349)4.00350700
26Bony spicule pigmentary retinopathy (HP:0007737)3.98991261
27Squamous cell carcinoma (HP:0002860)3.79430171
28Enlarged epiphyses (HP:0010580)3.78733611
29Chorioretinal atrophy (HP:0000533)3.74896595
30Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.72269661
31Hemorrhage of the eye (HP:0011885)3.64391452
32Prolonged partial thromboplastin time (HP:0003645)3.59417229
33Abnormality of the costochondral junction (HP:0000919)3.45220174
34Mesangial abnormality (HP:0001966)3.33457485
35Joint hemorrhage (HP:0005261)3.33165374
36Myotonia (HP:0002486)3.30912841
37Short chin (HP:0000331)3.26770768
38Patellar aplasia (HP:0006443)3.24955529
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.21818572
40Widely patent fontanelles and sutures (HP:0004492)3.08267697
41Capillary hemangiomas (HP:0005306)3.08234505
42Hypophosphatemic rickets (HP:0004912)3.07832625
43Aplasia/Hypoplasia of the patella (HP:0006498)3.03369225
44Decreased central vision (HP:0007663)3.00501244
45Abnormal albumin level (HP:0012116)2.93878658
46Hypoalbuminemia (HP:0003073)2.93878658
47Anteriorly placed anus (HP:0001545)2.92256365
48Atrioventricular block (HP:0001678)2.84675500
49Type 2 muscle fiber atrophy (HP:0003554)2.82488274
50Malignant hyperthermia (HP:0002047)2.81024951
51Aplasia/Hypoplasia involving the musculature (HP:0001460)2.80211511
52Choroideremia (HP:0001139)2.80070563
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.73891630
54Renal Fanconi syndrome (HP:0001994)2.70308359
55Pterygium (HP:0001059)2.68043104
56Thin ribs (HP:0000883)2.64251964
57Flat occiput (HP:0005469)2.62250440
58Increased hepatocellular lipid droplets (HP:0006565)2.61239090
59Birth length less than 3rd percentile (HP:0003561)2.60144937
60Neonatal respiratory distress (HP:0002643)2.52777776
61Pendular nystagmus (HP:0012043)2.52372440
62Muscle fiber atrophy (HP:0100295)2.49214103
63Lipid accumulation in hepatocytes (HP:0006561)2.49060307
64Reduced antithrombin III activity (HP:0001976)2.45181468
65Joint stiffness (HP:0001387)2.38614949
66Absent thumb (HP:0009777)2.37792752
67Bowing of the arm (HP:0006488)2.37773745
68Bowed forearm bones (HP:0003956)2.37773745
69Choanal stenosis (HP:0000452)2.36720998
70Fatigable weakness (HP:0003473)2.35680299
71Abnormality of the neuromuscular junction (HP:0003398)2.35680299
72Short humerus (HP:0005792)2.34907430
73Male infertility (HP:0003251)2.32301407
74Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.30481653
75Increased number of teeth (HP:0011069)2.25805296
76Narrow nasal bridge (HP:0000446)2.24548441
77Abnormal epiphyseal ossification (HP:0010656)2.22576598
78Diminished movement (HP:0002374)2.15179122
79Zonular cataract (HP:0010920)2.14834713
80Cystic hygroma (HP:0000476)2.12770182
81Premature graying of hair (HP:0002216)2.10506721
82Aplasia/hypoplasia of the humerus (HP:0006507)2.08549206
83Basal cell carcinoma (HP:0002671)2.08291879
84Small hand (HP:0200055)2.05241770
85Absent radius (HP:0003974)2.01831646
86Breast hypoplasia (HP:0003187)2.01531158
87Neonatal onset (HP:0003623)2.00839733
88Increased intramyocellular lipid droplets (HP:0012240)1.96866812
89Abnormal drinking behavior (HP:0030082)1.92033960
90Polydipsia (HP:0001959)1.92033960
91Myopathic facies (HP:0002058)1.89959993
92Absent forearm bone (HP:0003953)1.87300448
93Aplasia involving forearm bones (HP:0009822)1.87300448
94Heart block (HP:0012722)1.85780389
95Metaphyseal irregularity (HP:0003025)1.83684994
96Increased muscle lipid content (HP:0009058)1.83036886
97Wide cranial sutures (HP:0010537)1.79882294
98Short thumb (HP:0009778)1.79576871
99Homocystinuria (HP:0002156)1.77822254
100Abnormality of homocysteine metabolism (HP:0010919)1.77822254

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.80078815
2WNK46.19598401
3MUSK3.53158869
4TLK13.49562973
5BLK3.32848905
6TESK21.91877470
7GRK61.90865559
8ADRBK21.87467159
9ACVR1B1.79931029
10WNK11.74863143
11STK161.71954541
12ZAK1.71622294
13CCNB11.49637378
14MST1R1.45353077
15DYRK1B1.41784408
16ADRBK11.40659579
17SIK21.40201171
18MAP2K61.29742432
19BMPR1B1.27873235
20PDK21.25586479
21ERN11.15905513
22STK391.15621009
23CASK1.10350490
24SIK11.09081637
25CDK151.08866802
26PDPK11.07047544
27CDK11A1.04965852
28CDK181.02250145
29NEK21.00843865
30MET0.93428392
31TRIM280.90105959
32ZAP700.85488783
33DAPK20.83963862
34MAP3K90.83924187
35CSNK1D0.82017129
36TRIB30.81151871
37PIM20.80600861
38PRKD20.78492002
39CDK140.76677290
40MAP2K30.74797343
41PRKD30.73283176
42FRK0.68928497
43CDK40.68792395
44CDK60.68711516
45MARK10.65866590
46MAPK120.65211901
47TBK10.65201616
48RPS6KA20.64795034
49RPS6KA50.63982796
50BMX0.63476200
51PRKD10.62916523
52IRAK20.62048147
53PRKAA10.61702435
54ARAF0.58680654
55GRK10.57167244
56DYRK20.56500367
57TGFBR10.53422638
58CHEK20.53089270
59MAPK110.52222261
60PIK3CG0.51742874
61SGK2230.50493026
62SGK4940.50493026
63RPS6KA60.47835768
64ATR0.46994735
65EPHB20.46687763
66MAPK80.46610924
67CSNK1G30.44104462
68CSNK1A1L0.42464135
69AURKA0.42242876
70OXSR10.42204815
71PAK60.41620149
72PRKCG0.40645305
73CSK0.39931521
74PAK10.37818580
75PLK10.34913266
76MELK0.34857480
77CDK50.34155241
78MTOR0.33193387
79PHKG10.32012119
80PHKG20.32012119
81RPS6KL10.31884490
82RPS6KC10.31884490
83PRKACA0.31421374
84MAPK130.29400695
85ERBB20.28242163
86NEK60.28077967
87CSNK1G20.28002968
88STK380.24672721
89MAP2K40.23972470
90PINK10.23955254
91MAP2K70.23908321
92PRKG10.22844195
93DAPK30.22262930
94ROCK10.21722557
95PRKACG0.21434806
96PRKCA0.21161100
97STK38L0.21094225
98AKT30.20694320
99CDK10.20290650
100PKN10.20119298

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.41890953
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.47472183
3Sulfur relay system_Homo sapiens_hsa041226.12082775
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.28001418
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.12442034
6Fructose and mannose metabolism_Homo sapiens_hsa000512.90402351
7Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.40986229
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.28087246
9Circadian rhythm_Homo sapiens_hsa047101.95457427
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.95203672
11Taste transduction_Homo sapiens_hsa047421.92551170
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88645472
13Nicotine addiction_Homo sapiens_hsa050331.76865509
14Fanconi anemia pathway_Homo sapiens_hsa034601.69321557
15Sphingolipid metabolism_Homo sapiens_hsa006001.69186457
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67402244
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.49016429
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43434592
19Hedgehog signaling pathway_Homo sapiens_hsa043401.42548915
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28313017
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23701327
22Vitamin digestion and absorption_Homo sapiens_hsa049771.04553871
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02768329
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.99726022
25Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98311080
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97353279
27Pyruvate metabolism_Homo sapiens_hsa006200.82064486
28Arginine biosynthesis_Homo sapiens_hsa002200.80349240
29Calcium signaling pathway_Homo sapiens_hsa040200.79410405
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78673492
31Primary bile acid biosynthesis_Homo sapiens_hsa001200.77137290
32Phenylalanine metabolism_Homo sapiens_hsa003600.74454003
33Chemical carcinogenesis_Homo sapiens_hsa052040.72623843
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.71805578
35Cocaine addiction_Homo sapiens_hsa050300.71538624
36Ovarian steroidogenesis_Homo sapiens_hsa049130.66713732
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.66598355
38Phototransduction_Homo sapiens_hsa047440.66410150
39Hippo signaling pathway_Homo sapiens_hsa043900.63337958
40RNA polymerase_Homo sapiens_hsa030200.62543669
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58534586
42Nitrogen metabolism_Homo sapiens_hsa009100.58284053
43Alcoholism_Homo sapiens_hsa050340.56701741
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56081438
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55658138
46ABC transporters_Homo sapiens_hsa020100.55640548
47Inositol phosphate metabolism_Homo sapiens_hsa005620.55637978
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.55177976
49Glutamatergic synapse_Homo sapiens_hsa047240.50310422
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.49053020
51Morphine addiction_Homo sapiens_hsa050320.47482612
52Basal cell carcinoma_Homo sapiens_hsa052170.47134489
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45984845
54Bile secretion_Homo sapiens_hsa049760.45685814
55Lysosome_Homo sapiens_hsa041420.45626391
56Sulfur metabolism_Homo sapiens_hsa009200.41536502
57Biosynthesis of amino acids_Homo sapiens_hsa012300.41530944
58Lysine degradation_Homo sapiens_hsa003100.40704964
59Basal transcription factors_Homo sapiens_hsa030220.39418635
60Metabolic pathways_Homo sapiens_hsa011000.38924060
61Melanogenesis_Homo sapiens_hsa049160.38153569
62Non-homologous end-joining_Homo sapiens_hsa034500.36027134
63Cholinergic synapse_Homo sapiens_hsa047250.35127058
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.35074973
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34961730
66Fatty acid degradation_Homo sapiens_hsa000710.33552786
67GABAergic synapse_Homo sapiens_hsa047270.31793793
68Circadian entrainment_Homo sapiens_hsa047130.31489225
69Peroxisome_Homo sapiens_hsa041460.30008289
70Systemic lupus erythematosus_Homo sapiens_hsa053220.29342926
71Linoleic acid metabolism_Homo sapiens_hsa005910.28047680
72Glycerolipid metabolism_Homo sapiens_hsa005610.26079538
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.26039864
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.25961283
75Fat digestion and absorption_Homo sapiens_hsa049750.25744614
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25202858
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25172015
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24537757
79Gap junction_Homo sapiens_hsa045400.24101347
80Retinol metabolism_Homo sapiens_hsa008300.24041155
81Homologous recombination_Homo sapiens_hsa034400.23097563
82Amphetamine addiction_Homo sapiens_hsa050310.20846023
83Endocytosis_Homo sapiens_hsa041440.20262240
84Serotonergic synapse_Homo sapiens_hsa047260.19748698
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.18950787
86Histidine metabolism_Homo sapiens_hsa003400.18446039
87Tryptophan metabolism_Homo sapiens_hsa003800.17690559
88Base excision repair_Homo sapiens_hsa034100.16921912
89Arginine and proline metabolism_Homo sapiens_hsa003300.16671706
90PPAR signaling pathway_Homo sapiens_hsa033200.16426838
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.15805806
92Dorso-ventral axis formation_Homo sapiens_hsa043200.14363801
93Mineral absorption_Homo sapiens_hsa049780.13963243
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13414835
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11428278
96mTOR signaling pathway_Homo sapiens_hsa041500.11298158
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.09930351
98Other glycan degradation_Homo sapiens_hsa005110.08919194
99Pyrimidine metabolism_Homo sapiens_hsa002400.07595689
100cAMP signaling pathway_Homo sapiens_hsa040240.06761279

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