FOXD4L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)8.87062040
2cellular response to ATP (GO:0071318)8.85975016
3negative regulation of cell aging (GO:0090344)8.38031230
4regulation of skeletal muscle contraction (GO:0014819)8.29992253
5adenosine receptor signaling pathway (GO:0001973)7.87256184
6DNA strand renaturation (GO:0000733)7.56093481
7peptidyl-glutamic acid carboxylation (GO:0017187)7.34590521
8protein carboxylation (GO:0018214)7.34590521
9regulation of synapse structural plasticity (GO:0051823)7.04448679
10GDP-mannose metabolic process (GO:0019673)6.88787765
11regulation of cytokine production involved in inflammatory response (GO:1900015)6.84171912
12detection of light stimulus involved in sensory perception (GO:0050962)6.62837889
13detection of light stimulus involved in visual perception (GO:0050908)6.62837889
14mitotic cell cycle arrest (GO:0071850)6.52519701
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)6.10108530
16histone H3-K9 demethylation (GO:0033169)6.07670960
17lens fiber cell differentiation (GO:0070306)5.99344771
18sensory perception of taste (GO:0050909)5.79985859
19purinergic nucleotide receptor signaling pathway (GO:0035590)5.69861354
20rRNA methylation (GO:0031167)5.39198192
21transepithelial transport (GO:0070633)5.09455528
22piRNA metabolic process (GO:0034587)5.06744586
23adenine nucleotide transport (GO:0051503)4.79190878
24cysteine metabolic process (GO:0006534)4.73540021
25response to ATP (GO:0033198)4.57826984
26positive regulation of protein kinase C signaling (GO:0090037)4.56198412
27purine ribonucleotide transport (GO:0015868)4.55160016
28nucleotide transmembrane transport (GO:1901679)4.54331044
29purinergic receptor signaling pathway (GO:0035587)4.47098003
30rRNA modification (GO:0000154)4.46492794
31sulfur amino acid catabolic process (GO:0000098)4.43822077
32positive regulation of heat generation (GO:0031652)4.41968606
33DNA methylation involved in gamete generation (GO:0043046)4.35713253
34negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.27317452
35leukotriene biosynthetic process (GO:0019370)4.27193291
36cellular anion homeostasis (GO:0030002)4.20380327
37cilium or flagellum-dependent cell motility (GO:0001539)4.16293016
38male meiosis I (GO:0007141)4.13455469
39G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.10870812
40purine nucleotide transport (GO:0015865)4.08797561
41estrogen biosynthetic process (GO:0006703)4.08232903
42histone H3-K36 demethylation (GO:0070544)4.07353473
43phosphate ion homeostasis (GO:0055062)4.07191738
44trivalent inorganic anion homeostasis (GO:0072506)4.07191738
45synaptonemal complex assembly (GO:0007130)3.94992641
46glutathione metabolic process (GO:0006749)3.94392213
47regulation of meiosis (GO:0040020)3.92375266
48behavioral response to nicotine (GO:0035095)3.84291403
49glutathione biosynthetic process (GO:0006750)3.83739580
50peristalsis (GO:0030432)3.82379967
51reciprocal DNA recombination (GO:0035825)3.77680463
52reciprocal meiotic recombination (GO:0007131)3.77680463
53type B pancreatic cell proliferation (GO:0044342)3.74919210
54urinary tract smooth muscle contraction (GO:0014848)3.69015210
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.68624917
56protein import into peroxisome matrix (GO:0016558)3.59089529
57nonribosomal peptide biosynthetic process (GO:0019184)3.58470195
58regulation of cell aging (GO:0090342)3.56867754
59heme transport (GO:0015886)3.56455260
60regulation of protein kinase A signaling (GO:0010738)3.56427955
61melanin biosynthetic process (GO:0042438)3.53985004
62grooming behavior (GO:0007625)3.53679817
63regulation of phospholipid biosynthetic process (GO:0071071)3.52639524
64sphingosine metabolic process (GO:0006670)3.50234351
65synaptonemal complex organization (GO:0070193)3.50129500
66negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)3.49289821
67peptidyl-glutamic acid modification (GO:0018200)3.46166580
68granulocyte differentiation (GO:0030851)3.41844371
69regulation of meiotic cell cycle (GO:0051445)3.40584030
70iron coordination entity transport (GO:1901678)3.40546163
71UV protection (GO:0009650)3.39067165
72gonadal mesoderm development (GO:0007506)3.35307502
73melanin metabolic process (GO:0006582)3.32605780
74fat-soluble vitamin catabolic process (GO:0042363)3.29498206
75vitamin catabolic process (GO:0009111)3.29498206
76dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.29491487
77histone phosphorylation (GO:0016572)3.28891780
78phosphatidylglycerol biosynthetic process (GO:0006655)3.25141261
79sialylation (GO:0097503)3.23901226
80regulation of heat generation (GO:0031650)3.22547753
81nucleoside transmembrane transport (GO:1901642)3.21227421
82regulation of hydrogen peroxide metabolic process (GO:0010310)3.18323724
83diol metabolic process (GO:0034311)3.17696793
84phosphatidylethanolamine biosynthetic process (GO:0006646)3.17652921
85meiosis I (GO:0007127)3.11293366
86chromosome organization involved in meiosis (GO:0070192)3.11109031
87activation of adenylate cyclase activity (GO:0007190)3.09575462
88neuromuscular synaptic transmission (GO:0007274)3.08097018
89response to gravity (GO:0009629)3.05387051
90phosphate ion transmembrane transport (GO:0035435)3.04580946
91sphingomyelin metabolic process (GO:0006684)3.03235499
92sex determination (GO:0007530)3.01075844
93mismatch repair (GO:0006298)2.99155076
94negative regulation of interleukin-8 production (GO:0032717)2.98506398
95positive regulation of catecholamine secretion (GO:0033605)2.98460556
96phosphatidylethanolamine metabolic process (GO:0046337)2.97053091
97male meiosis (GO:0007140)2.94996733
98positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94516016
99meiotic nuclear division (GO:0007126)2.92640053
100nucleotide-sugar biosynthetic process (GO:0009226)2.92094991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human4.56107789
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.90581447
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.83864084
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.38727165
5CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.16620249
6P68_20966046_ChIP-Seq_HELA_Human3.15901645
7TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.13031475
8XRN2_22483619_ChIP-Seq_HELA_Human2.86711578
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.78196933
10LXR_22292898_ChIP-Seq_THP-1_Human2.75832108
11MAF_26560356_Chip-Seq_TH2_Human2.68508072
12ERG_21242973_ChIP-ChIP_JURKAT_Human2.63009182
13BCL6_27268052_Chip-Seq_Bcells_Human2.52326693
14E2F1_20622854_ChIP-Seq_HELA_Human2.50633057
15BCOR_27268052_Chip-Seq_Bcells_Human2.42478255
16CTCF_27219007_Chip-Seq_Bcells_Human2.33674085
17MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.32066586
18DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.30168588
19VDR_24763502_ChIP-Seq_THP-1_Human2.23795963
20RARB_24833708_ChIP-Seq_LIVER_Mouse2.14379914
21PHF8_20622854_ChIP-Seq_HELA_Human2.11771877
22YY1_22570637_ChIP-Seq_MALME-3M_Human2.06856654
23MAF_26560356_Chip-Seq_TH1_Human1.99855969
24SMC4_20622854_ChIP-Seq_HELA_Human1.95328629
25RXRA_24833708_ChIP-Seq_LIVER_Mouse1.94315042
26CTCF_27219007_Chip-Seq_ERYTHROID_Human1.94106616
27RARA_24833708_ChIP-Seq_LIVER_Mouse1.88950298
28* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.88573399
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.87206925
30CTCF_21964334_Chip-Seq_Bcells_Human1.82961939
31TET1_21451524_ChIP-Seq_MESCs_Mouse1.82056683
32FOXP1_21924763_ChIP-Seq_HESCs_Human1.79487091
33CTCF_20526341_ChIP-Seq_ESCs_Human1.77044110
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.76776502
35RACK7_27058665_Chip-Seq_MCF-7_Human1.76610243
36IKZF1_21737484_ChIP-ChIP_HCT116_Human1.71834796
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.70715425
38SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69079802
39SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.68856137
40ERA_21632823_ChIP-Seq_H3396_Human1.68067361
41RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.66169164
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64680974
43DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.63807773
44TP53_22127205_ChIP-Seq_IMR90_Human1.61599315
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.59427176
46CTCF_21964334_ChIP-Seq_BJAB-B_Human1.56325800
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.54869241
48FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.52761939
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49790390
50NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.45035574
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44578233
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43902724
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42044898
54UTX_26944678_Chip-Seq_JUKART_Human1.41063371
55PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39615133
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39471899
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.38582324
58CREB1_26743006_Chip-Seq_LNCaP_Human1.37878592
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36675190
60* TAF2_19829295_ChIP-Seq_ESCs_Human1.35904986
61PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34877930
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34662068
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33507307
64ETS1_21867929_ChIP-Seq_TH2_Mouse1.29612810
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29610315
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26081360
67JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.24787580
68SA1_27219007_Chip-Seq_Bcells_Human1.24495326
69NANOG_20526341_ChIP-Seq_ESCs_Human1.24403699
70KDM2B_26808549_Chip-Seq_DND41_Human1.23105495
71ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22985407
72OCT4_19829295_ChIP-Seq_ESCs_Human1.22435556
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22224324
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21607088
75SOX2_21211035_ChIP-Seq_LN229_Human1.19726143
76* P300_27268052_Chip-Seq_Bcells_Human1.19187898
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17432102
78P53_21459846_ChIP-Seq_SAOS-2_Human1.15243124
79PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14424668
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.13891538
81SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13725665
82CIITA_25753668_ChIP-Seq_RAJI_Human1.13485980
83ATF3_27146783_Chip-Seq_COLON_Human1.11627248
84MYC_19829295_ChIP-Seq_ESCs_Human1.11358069
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11213689
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.11025381
87* OCT4_20526341_ChIP-Seq_ESCs_Human1.10935744
88MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10257454
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09866699
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.08530370
91TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.08259982
92TP53_22573176_ChIP-Seq_HFKS_Human1.08158995
93TCF7_22412390_ChIP-Seq_EML_Mouse1.07971954
94FOXM1_23109430_ChIP-Seq_U2OS_Human1.03727406
95DCP1A_22483619_ChIP-Seq_HELA_Human1.03578497
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03378560
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03019776
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01302671
99RAC3_21632823_ChIP-Seq_H3396_Human1.00621099
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00380728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation7.76338914
2MP0005174_abnormal_tail_pigmentation6.24831053
3MP0001986_abnormal_taste_sensitivity5.89969323
4MP0003136_yellow_coat_color5.74341767
5MP0005423_abnormal_somatic_nervous5.35947945
6MP0005409_darkened_coat_color3.42341940
7MP0002160_abnormal_reproductive_system3.03204007
8MP0001188_hyperpigmentation2.99631484
9MP0001756_abnormal_urination2.59892224
10MP0001968_abnormal_touch/_nociception2.47802307
11MP0001502_abnormal_circadian_rhythm2.43088593
12MP0000015_abnormal_ear_pigmentation2.34142734
13MP0005083_abnormal_biliary_tract2.27571288
14MP0008875_abnormal_xenobiotic_pharmacok2.22350326
15MP0004019_abnormal_vitamin_homeostasis2.18499348
16MP0003183_abnormal_peptide_metabolism2.03534664
17MP0000751_myopathy2.02278334
18MP0003453_abnormal_keratinocyte_physiol1.99247891
19MP0004381_abnormal_hair_follicle1.91047709
20MP0002638_abnormal_pupillary_reflex1.87604265
21MP0002736_abnormal_nociception_after1.78813489
22MP0002735_abnormal_chemical_nociception1.65269042
23MP0005551_abnormal_eye_electrophysiolog1.57206297
24MP0005410_abnormal_fertilization1.56046674
25MP0001661_extended_life_span1.52646859
26MP0000538_abnormal_urinary_bladder1.49714760
27MP0004043_abnormal_pH_regulation1.47689931
28MP0000013_abnormal_adipose_tissue1.47252616
29MP0005389_reproductive_system_phenotype1.43796934
30MP0003111_abnormal_nucleus_morphology1.35982657
31MP0001765_abnormal_ion_homeostasis1.31467589
32MP0004130_abnormal_muscle_cell1.30189707
33MP0005332_abnormal_amino_acid1.28425727
34MP0000750_abnormal_muscle_regeneration1.27833312
35MP0005330_cardiomyopathy1.22376211
36MP0001919_abnormal_reproductive_system1.21620908
37MP0002210_abnormal_sex_determination1.20206648
38MP0005377_hearing/vestibular/ear_phenot1.12367924
39MP0003878_abnormal_ear_physiology1.12367924
40MP0001664_abnormal_digestion1.07015117
41MP0010386_abnormal_urinary_bladder0.99016233
42MP0005501_abnormal_skin_physiology0.98625294
43MP0000427_abnormal_hair_cycle0.97827596
44MP0005584_abnormal_enzyme/coenzyme_acti0.97655260
45MP0005253_abnormal_eye_physiology0.92394437
46MP0001929_abnormal_gametogenesis0.90315346
47MP0002163_abnormal_gland_morphology0.89591098
48MP0003448_altered_tumor_morphology0.89387457
49MP0003693_abnormal_embryo_hatching0.85091387
50MP0000003_abnormal_adipose_tissue0.83810971
51MP0003698_abnormal_male_reproductive0.80733358
52MP0005365_abnormal_bile_salt0.80677396
53MP0005220_abnormal_exocrine_pancreas0.80598971
54MP0002909_abnormal_adrenal_gland0.79999284
55MP0010094_abnormal_chromosome_stability0.78460661
56MP0003077_abnormal_cell_cycle0.77925542
57MP0001145_abnormal_male_reproductive0.77406948
58MP0001958_emphysema0.76607516
59MP0000470_abnormal_stomach_morphology0.74604886
60MP0000358_abnormal_cell_content/0.74296375
61MP0005084_abnormal_gallbladder_morpholo0.71644163
62MP0005666_abnormal_adipose_tissue0.71103950
63MP0003011_delayed_dark_adaptation0.70606617
64MP0001970_abnormal_pain_threshold0.70580519
65MP0004215_abnormal_myocardial_fiber0.68743565
66MP0000367_abnormal_coat/_hair0.67946553
67MP0009643_abnormal_urine_homeostasis0.67839301
68MP0003705_abnormal_hypodermis_morpholog0.67606567
69MP0000653_abnormal_sex_gland0.66670333
70MP0001324_abnormal_eye_pigmentation0.65598322
71MP0002089_abnormal_postnatal_growth/wei0.64109888
72MP0000678_abnormal_parathyroid_gland0.63485254
73MP0002075_abnormal_coat/hair_pigmentati0.63440506
74MP0010771_integument_phenotype0.62947616
75MP0000778_abnormal_nervous_system0.60468502
76MP0001346_abnormal_lacrimal_gland0.59978661
77MP0005375_adipose_tissue_phenotype0.59736239
78MP0002928_abnormal_bile_duct0.59729853
79MP0002254_reproductive_system_inflammat0.59191127
80MP0008995_early_reproductive_senescence0.58680892
81MP0000747_muscle_weakness0.50983847
82MP0005076_abnormal_cell_differentiation0.48712657
83MP0002136_abnormal_kidney_physiology0.48454602
84MP0001119_abnormal_female_reproductive0.48287715
85MP0003172_abnormal_lysosome_physiology0.48239072
86MP0004957_abnormal_blastocyst_morpholog0.47103109
87MP0003699_abnormal_female_reproductive0.45981067
88MP0008872_abnormal_physiological_respon0.45446890
89MP0002019_abnormal_tumor_incidence0.44224404
90MP0001764_abnormal_homeostasis0.43793533
91MP0003806_abnormal_nucleotide_metabolis0.43192074
92MP0009384_cardiac_valve_regurgitation0.42819998
93MP0003137_abnormal_impulse_conducting0.42507719
94MP0000026_abnormal_inner_ear0.41577070
95MP0003303_peritoneal_inflammation0.41425203
96MP0000613_abnormal_salivary_gland0.40469137
97MP0003635_abnormal_synaptic_transmissio0.39035913
98MP0002161_abnormal_fertility/fecundity0.38233748
99MP0002063_abnormal_learning/memory/cond0.37258809
100MP0001191_abnormal_skin_condition0.37055493

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)7.26272017
2Testicular atrophy (HP:0000029)6.11879633
3Attenuation of retinal blood vessels (HP:0007843)5.62358010
4Aplasia/Hypoplasia involving the carpal bones (HP:0006502)5.21360831
5Rectovaginal fistula (HP:0000143)5.07648576
6Rectal fistula (HP:0100590)5.07648576
7Dyschromatopsia (HP:0007641)5.07552683
8Facial hemangioma (HP:0000329)4.94331466
9Poikiloderma (HP:0001029)4.91786001
10Intestinal fistula (HP:0100819)4.67835600
11Vaginal fistula (HP:0004320)4.53573203
12Mesangial abnormality (HP:0001966)4.51301763
13Annular pancreas (HP:0001734)4.42326435
14Abnormality of the intrinsic pathway (HP:0010989)4.41600882
15Thin bony cortex (HP:0002753)4.41108936
16Popliteal pterygium (HP:0009756)4.28647909
17Congenital stationary night blindness (HP:0007642)4.24039848
18Fetal akinesia sequence (HP:0001989)4.18106045
19Facial diplegia (HP:0001349)4.15081991
20Joint hemorrhage (HP:0005261)4.11941851
21Ulnar bowing (HP:0003031)4.09996473
22Coronal craniosynostosis (HP:0004440)4.08251862
23Akinesia (HP:0002304)3.99851178
24Prolonged partial thromboplastin time (HP:0003645)3.94445213
25Hemorrhage of the eye (HP:0011885)3.78733474
26Turricephaly (HP:0000262)3.76988257
27Decreased central vision (HP:0007663)3.76154643
28Aplasia of the musculature (HP:0100854)3.70052554
29Increased hepatocellular lipid droplets (HP:0006565)3.68263928
30Renal Fanconi syndrome (HP:0001994)3.67944022
31Amniotic constriction ring (HP:0009775)3.57484434
32Abnormality of placental membranes (HP:0011409)3.57484434
33Bony spicule pigmentary retinopathy (HP:0007737)3.57430506
34Lipid accumulation in hepatocytes (HP:0006561)3.48944224
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.44713665
36Choroideremia (HP:0001139)3.43419782
37Short chin (HP:0000331)3.28705889
38Chorioretinal atrophy (HP:0000533)3.27066222
39Enlarged epiphyses (HP:0010580)3.21860936
40Decreased electroretinogram (ERG) amplitude (HP:0000654)3.19801911
41Abnormal albumin level (HP:0012116)3.19102039
42Hypoalbuminemia (HP:0003073)3.19102039
43Delayed epiphyseal ossification (HP:0002663)3.17973129
44Abnormality of the costochondral junction (HP:0000919)3.16236951
45Squamous cell carcinoma (HP:0002860)3.05473464
46Patellar aplasia (HP:0006443)3.00367625
47Hypophosphatemic rickets (HP:0004912)2.87009055
48Neonatal respiratory distress (HP:0002643)2.78408349
49Aplasia/Hypoplasia of the patella (HP:0006498)2.77921278
50Anteriorly placed anus (HP:0001545)2.74824979
51Myotonia (HP:0002486)2.70851021
52Capillary hemangiomas (HP:0005306)2.59835705
53Atrioventricular block (HP:0001678)2.56803005
54Type I transferrin isoform profile (HP:0003642)2.55270046
55Neonatal onset (HP:0003623)2.54732923
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.53113788
57Widely patent fontanelles and sutures (HP:0004492)2.45855093
58Aplasia/Hypoplasia involving the musculature (HP:0001460)2.45074069
59Absent thumb (HP:0009777)2.40607048
60Joint stiffness (HP:0001387)2.37471545
61Zonular cataract (HP:0010920)2.37300907
62Increased intramyocellular lipid droplets (HP:0012240)2.34679057
63Abnormal epiphyseal ossification (HP:0010656)2.33541874
64Abnormality of renal resorption (HP:0011038)2.31804867
65Exertional dyspnea (HP:0002875)2.30438415
66Flat occiput (HP:0005469)2.30341573
67Short humerus (HP:0005792)2.26859647
68Birth length less than 3rd percentile (HP:0003561)2.25862097
69Bowing of the arm (HP:0006488)2.24800703
70Bowed forearm bones (HP:0003956)2.24800703
71Abnormal urine phosphate concentration (HP:0012599)2.24553719
72Increased muscle lipid content (HP:0009058)2.23966991
73Male infertility (HP:0003251)2.20281510
74Narrow nasal bridge (HP:0000446)2.19118076
75Vertebral arch anomaly (HP:0008438)2.15634640
76Increased number of teeth (HP:0011069)2.15335784
77Long clavicles (HP:0000890)2.14404246
78Premature graying of hair (HP:0002216)2.12371305
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.11601436
80Abnormal protein N-linked glycosylation (HP:0012347)2.11601436
81Abnormal protein glycosylation (HP:0012346)2.11601436
82Abnormal glycosylation (HP:0012345)2.11601436
83Epiphyseal stippling (HP:0010655)2.06620663
84Thin ribs (HP:0000883)2.06300392
85Abnormality of the common coagulation pathway (HP:0010990)2.01877317
86Cystic hygroma (HP:0000476)2.00591223
87Choanal stenosis (HP:0000452)1.98011089
88Absent radius (HP:0003974)1.97874130
89Aplasia/hypoplasia of the humerus (HP:0006507)1.95444409
90Cheilitis (HP:0100825)1.95024207
91Abnormality of the hepatic vasculature (HP:0006707)1.90336460
92Basal cell carcinoma (HP:0002671)1.89491716
93Abnormal drinking behavior (HP:0030082)1.88842152
94Polydipsia (HP:0001959)1.88842152
95Respiratory difficulties (HP:0002880)1.86834766
96Absent forearm bone (HP:0003953)1.86310125
97Aplasia involving forearm bones (HP:0009822)1.86310125
98Horizontal nystagmus (HP:0000666)1.84287314
99Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79853506
100Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79853506

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.61005996
2WNK45.69550595
3PNCK3.06683571
4MUSK3.00858682
5MET2.86934389
6BLK2.67292585
7BMX2.49691248
8WNK12.41075790
9TESK22.00518632
10CAMKK21.89174134
11CDK61.80100038
12STK161.77238696
13PTK2B1.74578931
14ACVR1B1.70412144
15GRK61.60076723
16PRKD31.59444933
17IRAK21.45770368
18ADRBK11.42570155
19TLK11.41745977
20DYRK1B1.39992633
21MAP2K31.25654882
22SIK21.21234994
23NEK91.15691664
24FGR1.13540274
25OXSR11.13071976
26CAMK1G1.12565408
27ARAF1.09562987
28CDK11A1.08317311
29STK391.06849645
30CCNB11.01497492
31CSF1R1.00112848
32CAMKK10.98893675
33CDK150.96400306
34PDPK10.94481283
35CDK190.93963642
36YES10.93172116
37MST1R0.90868427
38CDK180.88650481
39RET0.82521475
40MAP2K60.80384749
41MELK0.77146652
42RPS6KA60.76441095
43TRIM280.75611959
44SGK2230.74090504
45SGK4940.74090504
46STK110.73906956
47CDK40.73343451
48PRKD20.70871042
49PRPF4B0.64832307
50PRKD10.64646436
51STK380.63887254
52CDK140.62370519
53EPHA40.61919671
54ICK0.59667347
55CDK120.59332954
56RPS6KL10.57763772
57RPS6KC10.57763772
58ADRBK20.56286024
59CDK50.55316693
60MAP3K20.55160249
61AURKA0.52701118
62MAPK130.52647874
63TAF10.52067270
64CSK0.51752440
65SGK10.51129409
66DYRK30.51004579
67TBK10.50428260
68PLK20.48756166
69MAPK110.47974301
70ZAK0.47550093
71DAPK20.47407884
72EPHB20.45885477
73ZAP700.45660581
74PIM20.45085329
75IKBKE0.44752323
76PLK10.43713540
77CSNK1D0.43302265
78CAMK10.43099523
79UHMK10.42377114
80AKT20.41095028
81NEK20.39408627
82PDGFRB0.39073069
83PIM10.38107389
84FRK0.37628896
85RPS6KA50.36676118
86CAMK40.36592877
87HIPK20.36401529
88SGK20.35404554
89ATR0.34948938
90CHEK20.33573002
91PRKCI0.32308135
92MAPK80.31183773
93PRKAA10.29273674
94BMPR1B0.29251247
95RIPK40.28636183
96RPS6KA20.28613982
97ROCK10.25125550
98ERN10.22569373
99MAPK120.22081437
100RPS6KB10.19720901

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006047.40690930
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001306.36166071
3Sulfur relay system_Homo sapiens_hsa041225.32651342
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.48882028
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.65007408
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.01081286
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.17951997
8Fructose and mannose metabolism_Homo sapiens_hsa000511.94787880
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90346192
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.84002512
11Sphingolipid metabolism_Homo sapiens_hsa006001.82800532
12Fanconi anemia pathway_Homo sapiens_hsa034601.74056215
13Taste transduction_Homo sapiens_hsa047421.71953919
14Circadian rhythm_Homo sapiens_hsa047101.67279110
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49549950
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.44459430
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37430475
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27529962
19VEGF signaling pathway_Homo sapiens_hsa043701.26338133
20Amphetamine addiction_Homo sapiens_hsa050311.17342989
21Hedgehog signaling pathway_Homo sapiens_hsa043401.09170513
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08719947
23Nicotine addiction_Homo sapiens_hsa050331.06475870
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.06006950
25Calcium signaling pathway_Homo sapiens_hsa040201.00784477
26N-Glycan biosynthesis_Homo sapiens_hsa005101.00548365
27Vitamin digestion and absorption_Homo sapiens_hsa049770.92495308
28Cocaine addiction_Homo sapiens_hsa050300.88480608
29Ovarian steroidogenesis_Homo sapiens_hsa049130.75410214
30Lysosome_Homo sapiens_hsa041420.75176613
31Inositol phosphate metabolism_Homo sapiens_hsa005620.74125021
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71839895
33Glutamatergic synapse_Homo sapiens_hsa047240.68776592
34Basal transcription factors_Homo sapiens_hsa030220.68395327
35Phototransduction_Homo sapiens_hsa047440.67885277
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65675609
37mTOR signaling pathway_Homo sapiens_hsa041500.65118393
38Dorso-ventral axis formation_Homo sapiens_hsa043200.64930439
39Long-term potentiation_Homo sapiens_hsa047200.63999450
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63368366
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63109799
42Steroid biosynthesis_Homo sapiens_hsa001000.62786238
43Regulation of autophagy_Homo sapiens_hsa041400.60469220
44Axon guidance_Homo sapiens_hsa043600.60121397
45Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55451416
46Lysine degradation_Homo sapiens_hsa003100.51181865
47Oocyte meiosis_Homo sapiens_hsa041140.48377753
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48292896
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.46569073
50Homologous recombination_Homo sapiens_hsa034400.45615187
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44565530
52ABC transporters_Homo sapiens_hsa020100.44307616
53Gap junction_Homo sapiens_hsa045400.43120688
54Renin secretion_Homo sapiens_hsa049240.42744148
55Alcoholism_Homo sapiens_hsa050340.39738625
56Melanogenesis_Homo sapiens_hsa049160.37662504
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.35298621
58Chemical carcinogenesis_Homo sapiens_hsa052040.33228874
59Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32836730
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.32451182
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32298870
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.31692294
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.30697643
64MAPK signaling pathway_Homo sapiens_hsa040100.30211177
65Glucagon signaling pathway_Homo sapiens_hsa049220.29309316
66Hippo signaling pathway_Homo sapiens_hsa043900.28359192
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27302602
68B cell receptor signaling pathway_Homo sapiens_hsa046620.27171037
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.26206956
70Glutathione metabolism_Homo sapiens_hsa004800.25875665
71Endocytosis_Homo sapiens_hsa041440.23457011
72Bile secretion_Homo sapiens_hsa049760.23376812
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23124183
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.22634546
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.21919171
76Cholinergic synapse_Homo sapiens_hsa047250.21677336
77Linoleic acid metabolism_Homo sapiens_hsa005910.20452854
78T cell receptor signaling pathway_Homo sapiens_hsa046600.20123004
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19510629
80cAMP signaling pathway_Homo sapiens_hsa040240.19362605
81mRNA surveillance pathway_Homo sapiens_hsa030150.19213859
82Base excision repair_Homo sapiens_hsa034100.18672152
83PPAR signaling pathway_Homo sapiens_hsa033200.18007428
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17540657
85Oxytocin signaling pathway_Homo sapiens_hsa049210.17477630
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15961685
87Fat digestion and absorption_Homo sapiens_hsa049750.11786047
88Metabolic pathways_Homo sapiens_hsa011000.11563930
89Tuberculosis_Homo sapiens_hsa051520.10838520
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10783460
91RNA polymerase_Homo sapiens_hsa030200.10305711
92Pyruvate metabolism_Homo sapiens_hsa006200.10127669
93Cell cycle_Homo sapiens_hsa041100.09925416
94Basal cell carcinoma_Homo sapiens_hsa052170.09432633
95Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.08157250
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.08086442
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.07098985
98Glycerolipid metabolism_Homo sapiens_hsa005610.06707876
99Insulin resistance_Homo sapiens_hsa049310.06682375
100Arachidonic acid metabolism_Homo sapiens_hsa005900.06515742

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