FOXD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular basement membrane development (GO:0032836)6.26229574
2glomerular visceral epithelial cell development (GO:0072015)6.25187410
3glomerular epithelial cell development (GO:0072310)5.46172339
4mesenchymal cell proliferation (GO:0010463)5.11271323
5skin morphogenesis (GO:0043589)5.03199557
6cell proliferation involved in kidney development (GO:0072111)4.84533624
7metanephric mesenchyme development (GO:0072075)4.78547566
8* kidney mesenchyme development (GO:0072074)4.78547566
9cell proliferation involved in metanephros development (GO:0072203)4.67678873
10ovulation cycle (GO:0042698)4.61386314
11negative regulation of chondrocyte differentiation (GO:0032331)4.53245562
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.38440199
13outer ear morphogenesis (GO:0042473)4.19020138
14endodermal cell differentiation (GO:0035987)4.18302781
15mesenchyme morphogenesis (GO:0072132)4.15809008
16glomerulus development (GO:0032835)4.12196185
17cell migration involved in heart development (GO:0060973)4.10000861
18planar cell polarity pathway involved in neural tube closure (GO:0090179)4.03667139
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.02598186
20regulation of heart morphogenesis (GO:2000826)4.01989235
21establishment of planar polarity (GO:0001736)4.01160279
22establishment of tissue polarity (GO:0007164)4.01160279
23chondrocyte proliferation (GO:0035988)3.98217574
24branching involved in salivary gland morphogenesis (GO:0060445)3.97017409
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.92396139
26regulation of apoptotic process involved in morphogenesis (GO:1902337)3.85477253
27regulation of glomerulus development (GO:0090192)3.81457974
28lymph vessel development (GO:0001945)3.78310603
29hippo signaling (GO:0035329)3.77839916
30protein heterotrimerization (GO:0070208)3.76804245
31embryonic skeletal joint morphogenesis (GO:0060272)3.75461562
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.74392432
33basement membrane organization (GO:0071711)3.70905248
34COPI coating of Golgi vesicle (GO:0048205)3.70353290
35Golgi transport vesicle coating (GO:0048200)3.70353290
36positive regulation of blood vessel endothelial cell migration (GO:0043536)3.69973328
37negative regulation of cartilage development (GO:0061037)3.68340897
38polarized epithelial cell differentiation (GO:0030859)3.64385488
39cell-substrate junction assembly (GO:0007044)3.63019906
40cochlea morphogenesis (GO:0090103)3.60282323
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59601236
42regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.53851775
43mesonephros development (GO:0001823)3.53296661
44adherens junction assembly (GO:0034333)3.52968068
45neural crest cell development (GO:0014032)3.49368355
46convergent extension (GO:0060026)3.46664700
47protein retention in ER lumen (GO:0006621)3.45561376
48protein localization to endosome (GO:0036010)3.44527848
49heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.40711820
50negative regulation of striated muscle cell apoptotic process (GO:0010664)3.39572976
51cellular response to vitamin (GO:0071295)3.39303815
52adhesion of symbiont to host cell (GO:0044650)3.38920189
53virion attachment to host cell (GO:0019062)3.38920189
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38379667
55regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.36566745
56coronary vasculature morphogenesis (GO:0060977)3.35282431
57collagen fibril organization (GO:0030199)3.35123211
58regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.32247702
59embryonic camera-type eye morphogenesis (GO:0048596)3.28693744
60mesenchymal-epithelial cell signaling (GO:0060638)3.28274541
61cell-substrate adherens junction assembly (GO:0007045)3.27944212
62focal adhesion assembly (GO:0048041)3.27944212
63cell migration involved in sprouting angiogenesis (GO:0002042)3.24137519
64regulation of cell proliferation involved in kidney development (GO:1901722)3.23151403
65mesenchymal to epithelial transition (GO:0060231)3.23037220
66vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.22189162
67positive regulation of metanephros development (GO:0072216)3.19852012
68hemidesmosome assembly (GO:0031581)3.19642715
69regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.19626409
70negative regulation of homotypic cell-cell adhesion (GO:0034111)3.16949744
71substrate-dependent cell migration (GO:0006929)3.16342351
72mesenchymal cell development (GO:0014031)3.15951637
73regulation of hippo signaling (GO:0035330)3.15176270
74establishment of apical/basal cell polarity (GO:0035089)3.12800913
75mesodermal cell differentiation (GO:0048333)3.11754078
76endocardial cushion morphogenesis (GO:0003203)3.11590437
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.11537596
78heterochromatin organization (GO:0070828)3.09968929
79embryonic digestive tract development (GO:0048566)3.09861788
80regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.09567000
81cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08955993
82proximal/distal pattern formation (GO:0009954)3.07132147
83regulation of organ formation (GO:0003156)3.06275109
84bone trabecula formation (GO:0060346)3.05020497
85regulation of cardioblast proliferation (GO:0003264)3.04053194
86regulation of secondary heart field cardioblast proliferation (GO:0003266)3.04053194
87cellular response to vitamin D (GO:0071305)3.02410000
88cartilage morphogenesis (GO:0060536)3.01174593
89* mesenchyme development (GO:0060485)3.01149010
90cell surface receptor signaling pathway involved in heart development (GO:0061311)3.00065414
91stress fiber assembly (GO:0043149)2.98620185
92regulation of establishment of planar polarity (GO:0090175)2.97723841
93sequestering of extracellular ligand from receptor (GO:0035581)2.97089402
94dermatan sulfate biosynthetic process (GO:0030208)2.96867051
95adhesion of symbiont to host (GO:0044406)2.94321400
96positive regulation of fatty acid beta-oxidation (GO:0032000)2.92930699
97regulation of early endosome to late endosome transport (GO:2000641)2.90705028
98negative regulation of catenin import into nucleus (GO:0035414)2.87684062
99dermatan sulfate metabolic process (GO:0030205)2.87124038
100craniofacial suture morphogenesis (GO:0097094)2.86166212
101lateral sprouting from an epithelium (GO:0060601)2.86076117
102positive regulation of SMAD protein import into nucleus (GO:0060391)2.85715440
103regulation of SMAD protein import into nucleus (GO:0060390)2.84132431
104endothelial cell morphogenesis (GO:0001886)2.83560079
105enteric nervous system development (GO:0048484)2.83480951
106non-canonical Wnt signaling pathway (GO:0035567)2.83420686
107metanephros development (GO:0001656)2.82333082
108embryonic eye morphogenesis (GO:0048048)2.82002097
109eye morphogenesis (GO:0048592)2.81965250
110ventricular cardiac muscle cell development (GO:0055015)2.81099633
111extracellular matrix assembly (GO:0085029)2.80886533
112epithelial to mesenchymal transition (GO:0001837)2.80076647
113trabecula formation (GO:0060343)2.79232644
114branching involved in ureteric bud morphogenesis (GO:0001658)2.78918010
115tooth mineralization (GO:0034505)2.77362080
116retina vasculature morphogenesis in camera-type eye (GO:0061299)2.77076964
117mesoderm formation (GO:0001707)2.76735440
118paraxial mesoderm development (GO:0048339)2.76426984
119embryonic cranial skeleton morphogenesis (GO:0048701)2.76010521
120muscle cell migration (GO:0014812)2.75948539
121blood vessel endothelial cell migration (GO:0043534)2.75458060
122cell adhesion mediated by integrin (GO:0033627)2.74388542
123negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.74120411
124positive regulation of mesenchymal cell proliferation (GO:0002053)2.73737849
125glial cell migration (GO:0008347)2.73590906
126mesonephric tubule development (GO:0072164)2.73429091
127cranial nerve morphogenesis (GO:0021602)2.73294287
128regulation of metanephros development (GO:0072215)2.71575818
129barbed-end actin filament capping (GO:0051016)2.71351940
130mesenchymal cell differentiation (GO:0048762)2.71133456
131positive regulation of axon extension (GO:0045773)2.69204297
132middle ear morphogenesis (GO:0042474)2.69058192
133positive regulation of catenin import into nucleus (GO:0035413)2.68668600
134negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.67432810
135regulation of stem cell maintenance (GO:2000036)2.67132847
136vascular endothelial growth factor signaling pathway (GO:0038084)2.66778036
137wound healing, spreading of epidermal cells (GO:0035313)2.66715382
138negative regulation of fatty acid transport (GO:2000192)2.66175429
139protein hydroxylation (GO:0018126)2.65859526
140regulation of cartilage development (GO:0061035)2.65796040
141establishment of monopolar cell polarity (GO:0061162)2.65219273
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.65219273
143atrial septum morphogenesis (GO:0060413)2.65160569
144negative regulation of smooth muscle cell migration (GO:0014912)2.64900673
145regulation of striated muscle cell apoptotic process (GO:0010662)2.64881554
146negative regulation of stem cell proliferation (GO:2000647)2.64659402
147stem cell development (GO:0048864)2.64260727
148regulation of catenin import into nucleus (GO:0035412)2.64245427
149mesonephric epithelium development (GO:0072163)2.64242678
150regulation of glucocorticoid metabolic process (GO:0031943)2.64056598
151regulation of translational termination (GO:0006449)2.63511089
152cranial suture morphogenesis (GO:0060363)2.63481438
153atrioventricular valve morphogenesis (GO:0003181)2.62379092
154collagen metabolic process (GO:0032963)2.61775651
155regulation of mesenchymal cell apoptotic process (GO:2001053)2.61496922
156type B pancreatic cell proliferation (GO:0044342)2.61033328
157regulation of mesenchymal cell proliferation (GO:0010464)2.60145224
158protein maturation by protein folding (GO:0022417)2.59317782
159artery morphogenesis (GO:0048844)2.59091900
160mitotic nuclear envelope reassembly (GO:0007084)2.58871123
161nuclear envelope reassembly (GO:0031468)2.58871123
162heparan sulfate proteoglycan metabolic process (GO:0030201)2.58694856
163embryonic viscerocranium morphogenesis (GO:0048703)2.58299656
164negative regulation of axon extension involved in axon guidance (GO:0048843)2.57586751
165outflow tract septum morphogenesis (GO:0003148)2.57333182
166positive regulation of epithelial to mesenchymal transition (GO:0010718)2.57231873
167peptidyl-proline hydroxylation (GO:0019511)2.54762798
168endocardial cushion development (GO:0003197)2.54598538
169lymphangiogenesis (GO:0001946)2.51462851
170negative regulation of osteoblast proliferation (GO:0033689)2.50332328
171endocytic recycling (GO:0032456)2.49201713
172wound healing, spreading of cells (GO:0044319)2.48203909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.01395933
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.17522754
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.06449438
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.94697941
5* EED_16625203_ChIP-ChIP_MESCs_Mouse2.71488972
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69207782
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69207782
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69207782
9* TP53_20018659_ChIP-ChIP_R1E_Mouse2.67675337
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.61137308
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.57396449
12NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.56422692
13* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.51030953
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.43786969
15ESR1_15608294_ChIP-ChIP_MCF-7_Human2.40195371
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.39123938
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.37570093
18* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35524355
19* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35524355
20TP53_22127205_ChIP-Seq_IMR90_Human2.15460436
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10977948
22* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10352001
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08821176
24* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07003412
25* EZH2_27304074_Chip-Seq_ESCs_Mouse2.06488590
26* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05612689
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04359882
28* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98509685
29* RING1B_27294783_Chip-Seq_NPCs_Mouse1.97744813
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96243609
31CLOCK_20551151_ChIP-Seq_293T_Human1.95517173
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.92705976
33E2F7_22180533_ChIP-Seq_HELA_Human1.92568649
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.91899489
35* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.91318863
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.90393371
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.87064372
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.86872665
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86493195
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82515050
41UBF1/2_26484160_Chip-Seq_HMECs_Human1.82220798
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79988016
43AR_21909140_ChIP-Seq_LNCAP_Human1.78940598
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.77833743
45* RNF2_27304074_Chip-Seq_ESCs_Mouse1.76768649
46ATF3_27146783_Chip-Seq_COLON_Human1.76144461
47* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72979255
48RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72009677
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.70959522
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.70618588
51* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70413358
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70380604
53LXR_22292898_ChIP-Seq_THP-1_Human1.69169861
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.69091790
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.63984477
56* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63649017
57* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.62998300
58ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.62893415
59HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62733006
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61258816
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61258816
62NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59155568
63TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.58452781
64* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57944800
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57754598
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.57315880
67HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55330468
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.54603882
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54335317
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52601102
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52593420
72* CBX2_27304074_Chip-Seq_ESCs_Mouse1.52586275
73* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.51133729
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.50785443
75* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50133201
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.48605129
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47706211
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.46803569
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46786788
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.45949798
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45653990
82XRN2_22483619_ChIP-Seq_HELA_Human1.44651313
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41809615
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39813002
85ISL1_27105846_Chip-Seq_CPCs_Mouse1.39677747
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37505847
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36680795
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.34032996
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33423868
90KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31784814
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31642175
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31597673
93* EZH2_27294783_Chip-Seq_ESCs_Mouse1.31341411
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31082543
95* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30897150
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30693513
97* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.27701173
98STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27566127
99SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27417381
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27265408
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26096134
102ZNF263_19887448_ChIP-Seq_K562_Human1.25977732
103* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25448783
104SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.24817358
105CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23947633
106* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23142124
107ELK3_25401928_ChIP-Seq_HUVEC_Human1.22848123
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22146524
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22136488
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.22106365
111MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21535146
112SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20921180
113BRD4_25478319_ChIP-Seq_HGPS_Human1.19550010
114EP300_21415370_ChIP-Seq_HL-1_Mouse1.18044740
115CDX2_20551321_ChIP-Seq_CACO-2_Human1.17937232
116POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17488853
117MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.17462899
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17177516
119DCP1A_22483619_ChIP-Seq_HELA_Human1.16470363
120DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16449632
121* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14893363
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14825713
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14711836
124VDR_21846776_ChIP-Seq_THP-1_Human1.14007853
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13674564
126MYC_18358816_ChIP-ChIP_MESCs_Mouse1.13133909
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12893827
128* KDM2B_26808549_Chip-Seq_K562_Human1.12792571
129JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12783678
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.11542569
131CJUN_26792858_Chip-Seq_BT549_Human1.10809528
132NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09908826
133RACK7_27058665_Chip-Seq_MCF-7_Human1.09692580
134SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09206453
135ZNF274_21170338_ChIP-Seq_K562_Hela1.08988787
136NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08792547
137* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08405653
138ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07970216
139* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07506214
140* KDM2B_26808549_Chip-Seq_JURKAT_Human1.07120592
141SOX2_16153702_ChIP-ChIP_HESCs_Human1.05905127
142TP53_23651856_ChIP-Seq_MEFs_Mouse1.04290559
143NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04219308
144CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04105615
145SA1_22415368_ChIP-Seq_MEFs_Mouse1.03409940
146SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03189134
147MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02821774
148NANOG_16153702_ChIP-ChIP_HESCs_Human1.01377352
149FOXM1_23109430_ChIP-Seq_U2OS_Human1.01150089
150EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01147249
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99990895
152UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99968438
153SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99610439
154TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99037551
155SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97924790
156JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97424110
157TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96474057
158KDM2B_26808549_Chip-Seq_DND41_Human0.96223307

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology5.15583220
2MP0008438_abnormal_cutaneous_collagen4.16302021
3MP0005503_abnormal_tendon_morphology3.32462011
4MP0004272_abnormal_basement_membrane3.28249434
5MP0010030_abnormal_orbit_morphology3.25510377
6MP0002249_abnormal_larynx_morphology3.13737103
7MP0003385_abnormal_body_wall3.00556722
8MP0004233_abnormal_muscle_weight2.98751529
9MP0003122_maternal_imprinting2.69963922
10MP0002877_abnormal_melanocyte_morpholog2.69844286
11* MP0003942_abnormal_urinary_system2.68492428
12MP0003279_aneurysm2.54125236
13MP0009250_abnormal_appendicular_skeleto2.48923131
14MP0000049_abnormal_middle_ear2.32046114
15* MP0000534_abnormal_ureter_morphology2.19745807
16MP0003941_abnormal_skin_development2.18167579
17MP0002282_abnormal_trachea_morphology2.12250894
18MP0003705_abnormal_hypodermis_morpholog2.11809972
19MP0000762_abnormal_tongue_morphology2.09291883
20MP0005275_abnormal_skin_tensile2.08258929
21MP0003950_abnormal_plasma_membrane2.07043095
22MP0001879_abnormal_lymphatic_vessel1.95639970
23MP0002938_white_spotting1.92401456
24MP0003123_paternal_imprinting1.90388271
25MP0000013_abnormal_adipose_tissue1.87689495
26MP0003755_abnormal_palate_morphology1.87362829
27MP0001542_abnormal_bone_strength1.85960295
28MP0002653_abnormal_ependyma_morphology1.82312700
29MP0002932_abnormal_joint_morphology1.75419103
30MP0005508_abnormal_skeleton_morphology1.72297721
31MP0003937_abnormal_limbs/digits/tail_de1.67585045
32MP0009278_abnormal_bone_marrow1.57410802
33MP0009384_cardiac_valve_regurgitation1.56964191
34MP0001958_emphysema1.53553750
35MP0009053_abnormal_anal_canal1.51127986
36MP0003935_abnormal_craniofacial_develop1.50845292
37MP0002116_abnormal_craniofacial_bone1.49426077
38MP0002089_abnormal_postnatal_growth/wei1.49260794
39MP0000428_abnormal_craniofacial_morphol1.48774539
40MP0002233_abnormal_nose_morphology1.47423356
41MP0002108_abnormal_muscle_morphology1.47141360
42MP0006054_spinal_hemorrhage1.45461733
43MP0000733_abnormal_muscle_development1.43925274
44MP0000003_abnormal_adipose_tissue1.43285178
45MP0002009_preneoplasia1.41781917
46MP0003115_abnormal_respiratory_system1.41650646
47MP0003283_abnormal_digestive_organ1.40081992
48MP0002697_abnormal_eye_size1.38464669
49MP0010368_abnormal_lymphatic_system1.35576612
50MP0000163_abnormal_cartilage_morphology1.35326553
51MP0003136_yellow_coat_color1.26132907
52MP0003121_genomic_imprinting1.25675781
53MP0001293_anophthalmia1.25537117
54MP0000432_abnormal_head_morphology1.21157817
55MP0001270_distended_abdomen1.20515995
56MP0001286_abnormal_eye_development1.19644308
57MP0000767_abnormal_smooth_muscle1.18513935
58MP0005197_abnormal_uvea_morphology1.17994539
59MP0004134_abnormal_chest_morphology1.14521551
60MP0002111_abnormal_tail_morphology1.13815086
61MP0002092_abnormal_eye_morphology1.13055898
62MP0005167_abnormal_blood-brain_barrier1.12072305
63MP0003567_abnormal_fetal_cardiomyocyte1.10514912
64MP0001243_abnormal_dermal_layer1.09469753
65MP0002896_abnormal_bone_mineralization1.07766171
66MP0000759_abnormal_skeletal_muscle1.07292233
67MP0002109_abnormal_limb_morphology1.07211156
68MP0001340_abnormal_eyelid_morphology1.06938974
69MP0002177_abnormal_outer_ear1.06840327
70MP0005171_absent_coat_pigmentation1.05877405
71MP0005595_abnormal_vascular_smooth1.05654027
72MP0003091_abnormal_cell_migration1.05375856
73MP0005076_abnormal_cell_differentiation1.05003456
74MP0000751_myopathy1.03706462
75MP0000516_abnormal_urinary_system1.02828247
76MP0005367_renal/urinary_system_phenotyp1.02828247
77MP0002115_abnormal_skeleton_extremities1.02120985
78MP0002295_abnormal_pulmonary_circulatio1.01328426
79MP0000462_abnormal_digestive_system1.01126144
80MP0002114_abnormal_axial_skeleton0.99385836
81MP0002060_abnormal_skin_morphology0.99126488
82MP0001299_abnormal_eye_distance/0.97567233
83MP0000467_abnormal_esophagus_morphology0.95958321
84MP0006138_congestive_heart_failure0.94998382
85MP0004185_abnormal_adipocyte_glucose0.94663484
86MP0001348_abnormal_lacrimal_gland0.94489303
87MP0009780_abnormal_chondrocyte_physiolo0.93420186
88MP0002234_abnormal_pharynx_morphology0.93229071
89MP0010352_gastrointestinal_tract_polyps0.90568449
90MP0008932_abnormal_embryonic_tissue0.89270554
91MP0001614_abnormal_blood_vessel0.87861650
92MP0003938_abnormal_ear_development0.86459764
93MP0005501_abnormal_skin_physiology0.86273857
94MP0002128_abnormal_blood_circulation0.86270815
95MP0003111_abnormal_nucleus_morphology0.86016496
96MP0000778_abnormal_nervous_system0.85562773
97MP0002085_abnormal_embryonic_tissue0.84902401
98MP0002751_abnormal_autonomic_nervous0.83822476
99MP0005248_abnormal_Harderian_gland0.83403968
100MP0002084_abnormal_developmental_patter0.83340156
101MP0002113_abnormal_skeleton_development0.83201309
102MP0001849_ear_inflammation0.82423997
103MP0003119_abnormal_digestive_system0.81363849
104MP0000749_muscle_degeneration0.80888791
105MP0003448_altered_tumor_morphology0.80339361
106MP0004883_abnormal_blood_vessel0.80139975
107MP0000678_abnormal_parathyroid_gland0.80076315
108MP0005257_abnormal_intraocular_pressure0.79706616
109MP0003861_abnormal_nervous_system0.78987316
110MP0004858_abnormal_nervous_system0.78861564
111MP0008007_abnormal_cellular_replicative0.78856190
112MP0002925_abnormal_cardiovascular_devel0.78797821
113MP0000858_altered_metastatic_potential0.77953833
114MP0000350_abnormal_cell_proliferation0.76913051
115MP0002168_other_aberrant_phenotype0.76869291
116MP0005193_abnormal_anterior_eye0.75403466
117MP0001915_intracranial_hemorrhage0.73762545
118MP0003045_fibrosis0.73461341
119* MP0002081_perinatal_lethality0.72995182
120MP0000537_abnormal_urethra_morphology0.72991922
121MP0009379_abnormal_foot_pigmentation0.72837240
122MP0000750_abnormal_muscle_regeneration0.72774162
123MP0005375_adipose_tissue_phenotype0.72759229
124MP0005023_abnormal_wound_healing0.72411214
125MP0005621_abnormal_cell_physiology0.71716488
126MP0004197_abnormal_fetal_growth/weight/0.71621029
127MP0001346_abnormal_lacrimal_gland0.70763373
128MP0001324_abnormal_eye_pigmentation0.69243001
129MP0003566_abnormal_cell_adhesion0.68816707
130MP0010307_abnormal_tumor_latency0.68812241
131MP0005390_skeleton_phenotype0.67446204
132MP0000681_abnormal_thyroid_gland0.67212710

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.09577753
2Premature rupture of membranes (HP:0001788)4.43603608
3Shallow orbits (HP:0000586)4.20074852
4Ankle contracture (HP:0006466)3.80330317
5Facial shape deformation (HP:0011334)3.71545330
6Potter facies (HP:0002009)3.71545330
7Type 1 muscle fiber predominance (HP:0003803)3.49415708
8Broad metatarsal (HP:0001783)3.45981821
9Mesangial abnormality (HP:0001966)3.40987942
10Slender build (HP:0001533)3.28348457
11Arterial tortuosity (HP:0005116)3.27652912
12Renal duplication (HP:0000075)3.23798812
13Coronal craniosynostosis (HP:0004440)3.21748212
14Abnormal umbilical cord blood vessels (HP:0011403)3.21523238
15Single umbilical artery (HP:0001195)3.21523238
16Abnormality of the fetal cardiovascular system (HP:0010948)3.21523238
17Cerebral aneurysm (HP:0004944)3.20185165
18Vertebral compression fractures (HP:0002953)3.00161488
19Broad toe (HP:0001837)2.95385242
20Turricephaly (HP:0000262)2.94850522
21Abnormal number of incisors (HP:0011064)2.90009537
22Focal segmental glomerulosclerosis (HP:0000097)2.86711785
23Asymmetry of the thorax (HP:0001555)2.83947950
24Biconcave vertebral bodies (HP:0004586)2.83538624
25Mildly elevated creatine phosphokinase (HP:0008180)2.81844480
26Abnormality of the umbilical cord (HP:0010881)2.81553295
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.78544691
28Short 4th metacarpal (HP:0010044)2.78544691
29Bladder diverticulum (HP:0000015)2.74354642
30Broad hallux (HP:0010055)2.73998742
31Achilles tendon contracture (HP:0001771)2.73645119
32Long toe (HP:0010511)2.70910942
33Short nail (HP:0001799)2.68611656
34Soft skin (HP:0000977)2.63094249
35Midline defect of the nose (HP:0004122)2.62353473
36Atrophic scars (HP:0001075)2.62267242
37Tubular atrophy (HP:0000092)2.59594006
38Aortic dissection (HP:0002647)2.53383847
39Anophthalmia (HP:0000528)2.52190311
40Morphological abnormality of the middle ear (HP:0008609)2.52076321
41Distal lower limb amyotrophy (HP:0008944)2.51371783
42Spondylolisthesis (HP:0003302)2.50056631
43Mitral valve prolapse (HP:0001634)2.49596534
44Neonatal short-limb short stature (HP:0008921)2.48554831
45Preaxial foot polydactyly (HP:0001841)2.47147837
46Stage 5 chronic kidney disease (HP:0003774)2.46458141
47Buphthalmos (HP:0000557)2.44400184
48Abnormality of dentin (HP:0010299)2.42635242
49Generalized amyotrophy (HP:0003700)2.41835526
50Hyperacusis (HP:0010780)2.41215217
51Abnormality of the distal phalanges of the toes (HP:0010182)2.38403624
52Abnormality of the Achilles tendon (HP:0005109)2.37484405
53Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32836341
54Increased variability in muscle fiber diameter (HP:0003557)2.32324612
55Aplasia involving bones of the extremities (HP:0009825)2.26903880
56Aplasia involving bones of the upper limbs (HP:0009823)2.26903880
57Aplasia of the phalanges of the hand (HP:0009802)2.26903880
58Abnormality of the peritoneum (HP:0002585)2.26693137
59Selective tooth agenesis (HP:0001592)2.24132453
60Osteolytic defects of the hand bones (HP:0009699)2.22896920
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.22896920
62Aortic regurgitation (HP:0001659)2.18294206
63Blue sclerae (HP:0000592)2.17703054
64Bowel diverticulosis (HP:0005222)2.17117704
65Upper limb amyotrophy (HP:0009129)2.16971336
66Distal upper limb amyotrophy (HP:0007149)2.16971336
67Tubulointerstitial fibrosis (HP:0005576)2.14483476
68Deviation of the hallux (HP:0010051)2.13820532
69Nonimmune hydrops fetalis (HP:0001790)2.13437791
70Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13340002
71Vertebral hypoplasia (HP:0008417)2.13340002
72Stridor (HP:0010307)2.13280908
73Congenital glaucoma (HP:0001087)2.12721419
74Glomerulosclerosis (HP:0000096)2.11364064
75Short hallux (HP:0010109)2.11363578
76Abnormality of the acetabulum (HP:0003170)2.10671996
77Broad thumb (HP:0011304)2.10565421
78Broad long bones (HP:0005622)2.10195440
79Rib fusion (HP:0000902)2.08978307
80Hallux valgus (HP:0001822)2.08909661
81Increased connective tissue (HP:0009025)2.06949220
82Abnormality of the phalanges of the hallux (HP:0010057)2.06654501
83Short clavicles (HP:0000894)2.05390675
84Mesomelia (HP:0003027)2.03920731
85Abnormal delivery (HP:0001787)2.02791135
86Reduced subcutaneous adipose tissue (HP:0003758)2.01846386
87Knee flexion contracture (HP:0006380)2.01843888
88Ulnar bowing (HP:0003031)2.01768502
89Fragile skin (HP:0001030)2.00053870
90Cervical subluxation (HP:0003308)1.99744534
91Round ear (HP:0100830)1.99248319
92Abnormality of skeletal muscle fiber size (HP:0012084)1.98877481
93Nephritis (HP:0000123)1.98703016
94Down-sloping shoulders (HP:0200021)1.97075650
95Abnormality of the 4th metacarpal (HP:0010012)1.96895659
96Camptodactyly of toe (HP:0001836)1.96630055
97Abnormality of the parietal bone (HP:0002696)1.96560903
98Wormian bones (HP:0002645)1.96468165
99Broad finger (HP:0001500)1.96020852
100Dislocated radial head (HP:0003083)1.95978444
101Aplasia/Hypoplasia of the hallux (HP:0008362)1.95676550
102Slender long bone (HP:0003100)1.95531223
103Lower limb amyotrophy (HP:0007210)1.94960584
104Short humerus (HP:0005792)1.94555486
105Hyperextensible skin (HP:0000974)1.94284744
106Supernumerary spleens (HP:0009799)1.93984381
107Elbow flexion contracture (HP:0002987)1.93276038
108Genu recurvatum (HP:0002816)1.93177027
109Disproportionate tall stature (HP:0001519)1.92795004
110Difficulty climbing stairs (HP:0003551)1.92165375
111Hypoventilation (HP:0002791)1.92072742
112Fibular aplasia (HP:0002990)1.91561999
113Supernumerary ribs (HP:0005815)1.91121154
114Protruding ear (HP:0000411)1.90347317
115Aortic aneurysm (HP:0004942)1.89346328
116Abnormality of the 2nd finger (HP:0004100)1.88849497
117Breech presentation (HP:0001623)1.88164578
118Mitral stenosis (HP:0001718)1.88000137
119Hepatoblastoma (HP:0002884)1.87971158
120Broad phalanx (HP:0006009)1.87937151
121Missing ribs (HP:0000921)1.87300254
122Dilatation of the ascending aorta (HP:0005111)1.87042911
123Vascular tortuosity (HP:0004948)1.86148325
124Wide anterior fontanel (HP:0000260)1.85108588
125Delayed cranial suture closure (HP:0000270)1.84415905
126Cardiovascular calcification (HP:0011915)1.84352703
127Mild short stature (HP:0003502)1.83508912
128Aplasia/Hypoplasia of the clavicles (HP:0006710)1.83006968
129Limb-girdle muscle weakness (HP:0003325)1.82878354
130Joint laxity (HP:0001388)1.81779893
131Natal tooth (HP:0000695)1.79715348
132Broad distal phalanx of finger (HP:0009836)1.79436337
133Abnormality of the radial head (HP:0003995)1.79365314
134Joint stiffness (HP:0001387)1.78782702
135Aortic valve stenosis (HP:0001650)1.78520960
136Partial duplication of the phalanx of hand (HP:0009999)1.77474672
137Spinal cord lesions (HP:0100561)1.77174747
138Syringomyelia (HP:0003396)1.77174747
139Aplasia/hypoplasia of the humerus (HP:0006507)1.76057146
140Myelomeningocele (HP:0002475)1.74348445
141Lymphangioma (HP:0100764)1.73883299
142Follicular hyperkeratosis (HP:0007502)1.73759317
143Cutaneous finger syndactyly (HP:0010554)1.73548815
144Spinal rigidity (HP:0003306)1.73442178
145Broad phalanges of the hand (HP:0009768)1.72914348
146Peritonitis (HP:0002586)1.72020038
147Wrist flexion contracture (HP:0001239)1.70073310
148Mitral regurgitation (HP:0001653)1.69455756
149Bell-shaped thorax (HP:0001591)1.68878854
150Bowing of the arm (HP:0006488)1.68818363
151Bowed forearm bones (HP:0003956)1.68818363
152Arnold-Chiari malformation (HP:0002308)1.67471841
153Overgrowth (HP:0001548)1.66990685
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.66712464

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.60606125
2DDR24.59323332
3TRIB33.84795633
4PDGFRA3.83036188
5IRAK32.73786462
6EPHA22.61056371
7EEF2K2.32307153
8LATS22.29436799
9NME22.27237294
10PAK22.26616661
11PTK22.13677857
12TESK12.04944539
13BUB12.02693621
14ICK1.98433825
15TTN1.94104975
16NTRK11.91830127
17BMX1.79370767
18MOS1.71860352
19MET1.71019049
20CAMK1D1.70067000
21SMG11.67040407
22CAMK1G1.64181675
23TAOK21.59488421
24LATS11.54768741
25TYRO31.52018834
26PAK41.45728645
27UHMK11.45609807
28MST1R1.43987584
29PDGFRB1.42164416
30CDK121.40580458
31ROCK11.38834362
32PKN21.38174820
33MKNK11.36114987
34DYRK1B1.34376932
35ABL21.33648029
36MAP3K101.33271164
37WNK41.31481580
38ROCK21.29796081
39ARAF1.27759377
40NEK91.26757742
41FGFR11.26591495
42PIM21.24056172
43STK381.22612144
44TLK11.18771184
45MAP2K31.15870787
46TNIK1.13639782
47MTOR1.11991020
48SIK11.11566118
49FER1.11273837
50PNCK1.11262887
51PAK61.10729103
52MKNK21.04741370
53WNK11.03458349
54LRRK21.00990183
55MAP3K30.99600161
56PAK30.96843407
57FGR0.96073499
58PTK60.95165163
59PRPF4B0.94655564
60CDC42BPA0.93394604
61ALK0.92157500
62STK390.91699655
63PRKG20.91055852
64YES10.89000376
65BRAF0.88940829
66CDK60.87516487
67RPS6KB20.87100433
68RET0.87019825
69ERN10.86108211
70MAP3K60.83702539
71STK100.81687645
72IRAK20.79042266
73CHEK20.78946734
74ILK0.77705422
75PIM10.77617282
76TGFBR10.76829362
77TGFBR20.76611050
78INSR0.76053654
79SCYL20.74482612
80DMPK0.74403074
81AURKA0.72703928
82PRKD20.71970649
83PRKD30.68971001
84GRK50.68682529
85STK30.67899069
86STK40.67478370
87FLT30.66038014
88RIPK10.65712462
89CAMK40.65262266
90AKT30.64704272
91BLK0.64198164
92WEE10.64138839
93LMTK20.64043181
94TRPM70.62858248
95MELK0.62111647
96SRC0.61712513
97PASK0.61622148
98NEK20.60561621
99ITK0.58616928
100TESK20.58539891
101EPHB10.57603809
102IGF1R0.57477033
103GSK3A0.57089188
104BRSK10.56244909
105ADRBK10.56019420
106RPS6KC10.55914992
107RPS6KL10.55914992
108MAPK150.54744193
109MAP2K10.54314029
110PTK2B0.53983298
111RPS6KA20.53253844
112DYRK30.52994111
113GRK70.51673256
114PIK3CG0.50648690
115MAP3K80.50116565
116NEK10.50108252
117PRKCH0.48788115
118AURKB0.48630890
119CDK80.48006435
120MAPK10.47706443
121KSR20.46615925
122MAPK90.46142807
123PAK10.45133333
124CSNK1E0.44872678
125CDK90.44611273
126RPS6KA60.44584587
127ERBB30.44539828
128AKT20.43576510
129BCR0.43103471
130MAP3K130.42627440
131MAPK100.42217365
132CDK11A0.41680517
133CSNK1A1L0.41518706
134CLK10.41459042
135CSNK1G10.41077527
136ERBB40.40516141
137MYLK0.40005182
138LIMK10.39660321
139CDK140.38191114
140TIE10.38061916
141PRKD10.37803809
142CAMK2G0.37584281
143CDK70.36426214
144CDK150.36383820
145DAPK30.36094718
146CDK180.35611555
147NTRK30.35566572
148KSR10.33058890
149TTK0.32829202

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.72138471
2Basal cell carcinoma_Homo sapiens_hsa052173.40247555
3Hedgehog signaling pathway_Homo sapiens_hsa043403.07998915
4Hippo signaling pathway_Homo sapiens_hsa043902.86447208
5Focal adhesion_Homo sapiens_hsa045102.75334199
6Proteoglycans in cancer_Homo sapiens_hsa052052.38978592
7Small cell lung cancer_Homo sapiens_hsa052222.31780945
8Adherens junction_Homo sapiens_hsa045202.27620206
9Amoebiasis_Homo sapiens_hsa051462.03950836
10AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.03689998
11Axon guidance_Homo sapiens_hsa043602.02868095
12TGF-beta signaling pathway_Homo sapiens_hsa043502.01239472
13Bladder cancer_Homo sapiens_hsa052191.99122331
14MicroRNAs in cancer_Homo sapiens_hsa052061.96350662
15Nitrogen metabolism_Homo sapiens_hsa009101.96260556
16Protein digestion and absorption_Homo sapiens_hsa049741.94182049
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90424008
18Sulfur relay system_Homo sapiens_hsa041221.85632878
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.79643464
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.78100650
21Wnt signaling pathway_Homo sapiens_hsa043101.55247440
22PI3K-Akt signaling pathway_Homo sapiens_hsa041511.52033839
23Pathways in cancer_Homo sapiens_hsa052001.45799696
24Tight junction_Homo sapiens_hsa045301.45441649
25Notch signaling pathway_Homo sapiens_hsa043301.44230658
26Melanoma_Homo sapiens_hsa052181.38731298
27Chronic myeloid leukemia_Homo sapiens_hsa052201.38136939
28Prostate cancer_Homo sapiens_hsa052151.37196327
29Dilated cardiomyopathy_Homo sapiens_hsa054141.35056372
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.33998380
31Glioma_Homo sapiens_hsa052141.33296146
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33070119
33mTOR signaling pathway_Homo sapiens_hsa041501.32484761
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.30995022
35Thyroid cancer_Homo sapiens_hsa052161.27717228
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26762736
37Vibrio cholerae infection_Homo sapiens_hsa051101.26565679
38Melanogenesis_Homo sapiens_hsa049161.23250035
39Rap1 signaling pathway_Homo sapiens_hsa040151.21581476
40N-Glycan biosynthesis_Homo sapiens_hsa005101.19794609
41Fatty acid biosynthesis_Homo sapiens_hsa000611.18349010
42Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15700700
43Prion diseases_Homo sapiens_hsa050201.13127316
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.12425370
45Renal cell carcinoma_Homo sapiens_hsa052111.11649174
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10663155
47Renin-angiotensin system_Homo sapiens_hsa046141.10228502
48Gap junction_Homo sapiens_hsa045401.05347254
49Colorectal cancer_Homo sapiens_hsa052101.02099175
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.02032509
51DNA replication_Homo sapiens_hsa030301.00362455
52Pyrimidine metabolism_Homo sapiens_hsa002400.92136878
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92011546
54Endometrial cancer_Homo sapiens_hsa052130.90650925
55Estrogen signaling pathway_Homo sapiens_hsa049150.88658900
56Long-term depression_Homo sapiens_hsa047300.88443344
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87906108
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85499235
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82534356
60Cell cycle_Homo sapiens_hsa041100.80588663
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.80335961
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79870318
63Arginine biosynthesis_Homo sapiens_hsa002200.79021639
64Pentose phosphate pathway_Homo sapiens_hsa000300.77740944
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75903746
66Nucleotide excision repair_Homo sapiens_hsa034200.75529075
67Sulfur metabolism_Homo sapiens_hsa009200.75410844
68HIF-1 signaling pathway_Homo sapiens_hsa040660.74900363
69HTLV-I infection_Homo sapiens_hsa051660.74328618
70Viral myocarditis_Homo sapiens_hsa054160.74240087
71Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71662613
72Lysine degradation_Homo sapiens_hsa003100.71563848
73Apoptosis_Homo sapiens_hsa042100.69868661
74Salmonella infection_Homo sapiens_hsa051320.69398158
75Pancreatic cancer_Homo sapiens_hsa052120.68428724
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.67904611
77Galactose metabolism_Homo sapiens_hsa000520.67461374
78ErbB signaling pathway_Homo sapiens_hsa040120.67119095
79VEGF signaling pathway_Homo sapiens_hsa043700.67011192
80Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66430747
81p53 signaling pathway_Homo sapiens_hsa041150.65771334
82Cocaine addiction_Homo sapiens_hsa050300.65247495
83Ribosome_Homo sapiens_hsa030100.65241701
84Arginine and proline metabolism_Homo sapiens_hsa003300.64960068
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.64808434
86GnRH signaling pathway_Homo sapiens_hsa049120.64569340
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64465371
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62913016
89Ras signaling pathway_Homo sapiens_hsa040140.62911995
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.62375019
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61626636
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.60776875
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60075935
94Other glycan degradation_Homo sapiens_hsa005110.59583441
95mRNA surveillance pathway_Homo sapiens_hsa030150.58787739
96Dorso-ventral axis formation_Homo sapiens_hsa043200.58367491
97Non-small cell lung cancer_Homo sapiens_hsa052230.57969277
98Renin secretion_Homo sapiens_hsa049240.57931716
99Hepatitis B_Homo sapiens_hsa051610.57610747
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56227918
101MAPK signaling pathway_Homo sapiens_hsa040100.56188791
102Choline metabolism in cancer_Homo sapiens_hsa052310.54967777
103Biosynthesis of amino acids_Homo sapiens_hsa012300.54080079
104Platelet activation_Homo sapiens_hsa046110.53087964
105Thyroid hormone synthesis_Homo sapiens_hsa049180.53013446
106GABAergic synapse_Homo sapiens_hsa047270.52222191
107cAMP signaling pathway_Homo sapiens_hsa040240.51382876
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49485532
109Folate biosynthesis_Homo sapiens_hsa007900.49061348
110Vitamin B6 metabolism_Homo sapiens_hsa007500.47747969
111Oocyte meiosis_Homo sapiens_hsa041140.47693595
112TNF signaling pathway_Homo sapiens_hsa046680.46056605
113Acute myeloid leukemia_Homo sapiens_hsa052210.44830293
114Sphingolipid metabolism_Homo sapiens_hsa006000.44685043
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.44543244
116RNA transport_Homo sapiens_hsa030130.44498202
117Shigellosis_Homo sapiens_hsa051310.43239512
118Oxytocin signaling pathway_Homo sapiens_hsa049210.42667215
119Insulin signaling pathway_Homo sapiens_hsa049100.41256049
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40280074
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40022779
122Bile secretion_Homo sapiens_hsa049760.39312984
123AMPK signaling pathway_Homo sapiens_hsa041520.39086505
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38976329
125FoxO signaling pathway_Homo sapiens_hsa040680.38079844
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.37689436
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37158043
128Endocytosis_Homo sapiens_hsa041440.36939590
129Viral carcinogenesis_Homo sapiens_hsa052030.36457669
130Ovarian steroidogenesis_Homo sapiens_hsa049130.35745629
131cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33332179
132Spliceosome_Homo sapiens_hsa030400.33238867

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