FOXC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mammary gland epithelial cell proliferation (GO:0033599)6.47168169
2mammary gland epithelial cell differentiation (GO:0060644)5.59368032
3regulation of branching involved in prostate gland morphogenesis (GO:0060687)5.38413507
4negative regulation of homotypic cell-cell adhesion (GO:0034111)5.35770264
5proximal/distal pattern formation (GO:0009954)5.10817301
6thyroid gland development (GO:0030878)5.07015460
7chondrocyte proliferation (GO:0035988)4.86999390
8cranial nerve morphogenesis (GO:0021602)4.80497320
9outflow tract septum morphogenesis (GO:0003148)4.77593825
10peripheral nervous system neuron development (GO:0048935)4.77315292
11* collagen fibril organization (GO:0030199)4.75247238
12prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.67825897
13desmosome organization (GO:0002934)4.67254085
14regulation of chromatin binding (GO:0035561)4.63743125
15* lymph vessel development (GO:0001945)4.58260191
16heart trabecula formation (GO:0060347)4.56672239
17regulation of cardioblast differentiation (GO:0051890)4.38923502
18chondrocyte development (GO:0002063)4.33582185
19glomerular basement membrane development (GO:0032836)4.30669425
20embryonic skeletal system morphogenesis (GO:0048704)4.30460756
21endothelium development (GO:0003158)4.29857846
22branching involved in prostate gland morphogenesis (GO:0060442)4.13820745
23tooth mineralization (GO:0034505)4.13633500
24muscle cell fate commitment (GO:0042693)4.08846671
25embryonic forelimb morphogenesis (GO:0035115)4.05398363
26G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.04271502
27ventricular septum morphogenesis (GO:0060412)3.99461520
28organ induction (GO:0001759)3.98292235
29glomerular visceral epithelial cell development (GO:0072015)3.98202146
30ventricular trabecula myocardium morphogenesis (GO:0003222)3.96315914
31DNA replication checkpoint (GO:0000076)3.91080828
32skin morphogenesis (GO:0043589)3.86456134
33* neural crest cell development (GO:0014032)3.83633457
34heterochromatin organization (GO:0070828)3.82555526
35outer ear morphogenesis (GO:0042473)3.81923717
36vascular endothelial growth factor signaling pathway (GO:0038084)3.79869086
37lymphangiogenesis (GO:0001946)3.77988273
38* regulation of heart morphogenesis (GO:2000826)3.76346331
39forelimb morphogenesis (GO:0035136)3.76291952
40cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.71188258
41regulation of cardioblast proliferation (GO:0003264)3.70051565
42regulation of secondary heart field cardioblast proliferation (GO:0003266)3.70051565
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.66002042
44pattern specification involved in kidney development (GO:0061004)3.65923838
45aorta morphogenesis (GO:0035909)3.61691624
46protein heterotrimerization (GO:0070208)3.60148614
47trabecula formation (GO:0060343)3.57875247
48radial glial cell differentiation (GO:0060019)3.57674628
49kidney mesenchyme development (GO:0072074)3.56767650
50cochlea morphogenesis (GO:0090103)3.55281258
51regulation of NFAT protein import into nucleus (GO:0051532)3.53530949
52* mesenchymal cell development (GO:0014031)3.52707400
53mesenchyme morphogenesis (GO:0072132)3.51884590
54skeletal system morphogenesis (GO:0048705)3.51370484
55cardiac septum morphogenesis (GO:0060411)3.47987154
56* embryonic heart tube development (GO:0035050)3.46876128
57embryonic organ morphogenesis (GO:0048562)3.45134426
58glomerular epithelial cell development (GO:0072310)3.45097396
59cellular protein complex localization (GO:0034629)3.44660229
60middle ear morphogenesis (GO:0042474)3.43356353
61embryonic viscerocranium morphogenesis (GO:0048703)3.42984793
62retina vasculature morphogenesis in camera-type eye (GO:0061299)3.41444757
63mitotic sister chromatid cohesion (GO:0007064)3.39011232
64coronary vasculature morphogenesis (GO:0060977)3.37437281
65notochord development (GO:0030903)3.36917636
66positive regulation of endothelial cell apoptotic process (GO:2000353)3.33661648
67endothelial cell morphogenesis (GO:0001886)3.32918369
68metanephric mesenchyme development (GO:0072075)3.32362986
69regulation of organ formation (GO:0003156)3.31174755
70respiratory tube development (GO:0030323)3.31059798
71endocardial cushion morphogenesis (GO:0003203)3.25859051
72viral transcription (GO:0019083)3.25180374
73negative regulation of chondrocyte differentiation (GO:0032331)3.23799500
74epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.23385822
75adherens junction assembly (GO:0034333)3.22585883
76protein complex localization (GO:0031503)3.22440410
77diaphragm development (GO:0060539)3.21587058
78heart trabecula morphogenesis (GO:0061384)3.20211337
79mitotic chromosome condensation (GO:0007076)3.18217649
80negative regulation of cell fate specification (GO:0009996)3.18105458
81positive regulation of mesenchymal cell proliferation (GO:0002053)3.15442406
82planar cell polarity pathway involved in neural tube closure (GO:0090179)3.15317459
83morphogenesis of an epithelial fold (GO:0060571)3.15149048
84mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.13631749
85collagen metabolic process (GO:0032963)3.12685421
86negative regulation of keratinocyte proliferation (GO:0010839)3.12285834
87positive regulation of extracellular matrix organization (GO:1903055)3.11080391
88translational termination (GO:0006415)3.09886388
89positive regulation of epithelial to mesenchymal transition (GO:0010718)3.09358160
90hippo signaling (GO:0035329)3.09013703
91cell migration involved in sprouting angiogenesis (GO:0002042)3.08935908
92collagen catabolic process (GO:0030574)3.08579290
93neuron fate specification (GO:0048665)3.06995626
94neuron projection extension involved in neuron projection guidance (GO:1902284)3.05969382
95axon extension involved in axon guidance (GO:0048846)3.05969382
96cartilage morphogenesis (GO:0060536)3.05827652
97ventricular cardiac muscle cell development (GO:0055015)3.05475370
98mesenchymal-epithelial cell signaling (GO:0060638)3.04854248
99endodermal cell differentiation (GO:0035987)3.04740699
100cell adhesion mediated by integrin (GO:0033627)3.04522206
101regulation of mesenchymal cell proliferation (GO:0010464)3.04066995
102heart valve morphogenesis (GO:0003179)3.03228767
103negative regulation of mRNA processing (GO:0050686)3.02984269
104wound healing, spreading of epidermal cells (GO:0035313)3.02631872
105atrial septum morphogenesis (GO:0060413)3.02311490
106branch elongation of an epithelium (GO:0060602)3.02299928
107axis elongation (GO:0003401)3.02240868
108keratinocyte proliferation (GO:0043616)3.01055595
109mesenchymal to epithelial transition (GO:0060231)3.00571532
110heart valve formation (GO:0003188)3.00320782
111cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.99325072
112apoptotic process involved in morphogenesis (GO:0060561)2.97710387
113positive regulation of cartilage development (GO:0061036)2.96633185
114mesodermal cell differentiation (GO:0048333)2.96306584
115embryonic skeletal joint morphogenesis (GO:0060272)2.96276701
116multicellular organismal macromolecule metabolic process (GO:0044259)2.95448348
117regulation of glucocorticoid metabolic process (GO:0031943)2.95402808
118embryonic cranial skeleton morphogenesis (GO:0048701)2.95223954
119cardiac epithelial to mesenchymal transition (GO:0060317)2.95153746
120DNA unwinding involved in DNA replication (GO:0006268)2.94713688
121cell proliferation involved in kidney development (GO:0072111)2.92035549
122trabecula morphogenesis (GO:0061383)2.92021691
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.91654196
124regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.90987216
125Notch signaling involved in heart development (GO:0061314)2.90549832
126trophectodermal cell differentiation (GO:0001829)2.90280997
127epithelial to mesenchymal transition (GO:0001837)2.90164189
128* anterior/posterior pattern specification (GO:0009952)2.90097840
129facial nerve structural organization (GO:0021612)2.89947929
130hemidesmosome assembly (GO:0031581)2.89926724
131bone trabecula formation (GO:0060346)2.89524309
132nuclear pore complex assembly (GO:0051292)2.89500851
133renal filtration (GO:0097205)2.89497078
134cell aggregation (GO:0098743)2.88975144
135cartilage condensation (GO:0001502)2.88975144
136negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.88231285
137sequestering of extracellular ligand from receptor (GO:0035581)2.87228197
138* stem cell development (GO:0048864)2.87049772
139cell surface receptor signaling pathway involved in heart development (GO:0061311)2.86850555
140regulation of mesenchymal cell apoptotic process (GO:2001053)2.86538105
141glomerular filtration (GO:0003094)2.86486720
142negative regulation of embryonic development (GO:0045992)2.86126112
143multicellular organismal catabolic process (GO:0044243)2.86113438
144skeletal muscle organ development (GO:0060538)2.85982557
145regulation of translational termination (GO:0006449)2.85719710
146positive regulation of stem cell differentiation (GO:2000738)2.82355055
147pharyngeal system development (GO:0060037)2.81481829
148negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.80029828
149epithelial cell-cell adhesion (GO:0090136)2.79752146
150smooth muscle tissue development (GO:0048745)2.79232973
151ribosomal small subunit biogenesis (GO:0042274)2.78891728
152embryonic eye morphogenesis (GO:0048048)2.78081323
153multicellular organismal metabolic process (GO:0044236)2.76142399
154developmental induction (GO:0031128)2.76081103
155* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.75161356
156glomerulus development (GO:0032835)2.73472131
157cell-cell signaling involved in cell fate commitment (GO:0045168)2.73230574
158eyelid development in camera-type eye (GO:0061029)2.72927724
159negative regulation of catenin import into nucleus (GO:0035414)2.72177641
160maturation of SSU-rRNA (GO:0030490)2.71994579
161limb bud formation (GO:0060174)2.71467785
162regulation of cell fate specification (GO:0042659)2.70577279
163cellular response to vitamin D (GO:0071305)2.70441947
164positive regulation of hair cycle (GO:0042635)2.70026520
165positive regulation of hair follicle development (GO:0051798)2.70026520
166embryonic camera-type eye morphogenesis (GO:0048596)2.69392301
167negative regulation of erythrocyte differentiation (GO:0045647)2.69305456
168dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69202745
169protein localization to chromosome, centromeric region (GO:0071459)2.69065786
170negative regulation of cartilage development (GO:0061037)2.68668959
171protein localization to microtubule (GO:0035372)2.68607566
172regulation of transforming growth factor beta2 production (GO:0032909)2.68056146
173mesenchymal cell proliferation (GO:0010463)2.67243375
174regulation of nuclear cell cycle DNA replication (GO:0033262)2.66473820
175cell migration involved in heart development (GO:0060973)2.65779053
176patterning of blood vessels (GO:0001569)2.65747440
177nuclear pore organization (GO:0006999)2.65541542
178positive regulation of cell size (GO:0045793)2.64034423
179regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.63918148
180extracellular matrix disassembly (GO:0022617)2.63687042
181embryonic appendage morphogenesis (GO:0035113)2.62622182
182embryonic limb morphogenesis (GO:0030326)2.62622182
183negative regulation of cell fate commitment (GO:0010454)2.60418693

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.42635560
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.68706357
3E2F7_22180533_ChIP-Seq_HELA_Human5.34786174
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.17312643
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.44626274
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.98849169
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93136999
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.71476167
9* XRN2_22483619_ChIP-Seq_HELA_Human2.46047882
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.45518993
11SOX9_24532713_ChIP-Seq_HFSC_Mouse2.28190151
12CJUN_26792858_Chip-Seq_BT549_Human2.25282982
13CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.25068933
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.24427608
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.24111185
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.22188642
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.16318270
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.13388781
19VDR_21846776_ChIP-Seq_THP-1_Human2.11669996
20MYC_22102868_ChIP-Seq_BL_Human2.07407109
21ZNF217_24962896_ChIP-Seq_MCF-7_Human2.04767118
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04435554
23HIF1A_21447827_ChIP-Seq_MCF-7_Human2.03120610
24* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.01165572
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99298693
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95998008
27* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.94957805
28* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.94957805
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92191185
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.90811996
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.89958455
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.88177455
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.86767200
34* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.86521651
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.84938974
36* RACK7_27058665_Chip-Seq_MCF-7_Human1.83478441
37CLOCK_20551151_ChIP-Seq_293T_Human1.82819742
38TP53_18474530_ChIP-ChIP_U2OS_Human1.80821702
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.80336922
40BRD4_25478319_ChIP-Seq_HGPS_Human1.79402800
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78869367
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78263561
43* TTF2_22483619_ChIP-Seq_HELA_Human1.76985933
44CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76383738
45WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.75634792
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75307419
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.74281637
48* TP53_20018659_ChIP-ChIP_R1E_Mouse1.73246818
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.72676337
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.72387856
51* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.71100586
52* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.70853355
53* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70657414
54KDM2B_26808549_Chip-Seq_K562_Human1.69197200
55LXR_22292898_ChIP-Seq_THP-1_Human1.68165636
56* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67214353
57* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67214353
58* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66185269
59* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.66000724
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65238715
61NRF2_20460467_ChIP-Seq_MEFs_Mouse1.64931094
62NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.64931094
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64504355
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.64399113
65AR_21909140_ChIP-Seq_LNCAP_Human1.64271793
66ZNF263_19887448_ChIP-Seq_K562_Human1.60840789
67CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.60490756
68* SOX2_20726797_ChIP-Seq_SW620_Human1.59513695
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57392922
70KDM2B_26808549_Chip-Seq_DND41_Human1.56945190
71ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55750763
72FOXO3_23340844_ChIP-Seq_DLD1_Human1.55515819
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55272401
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.54286607
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51114252
76* EZH2_27304074_Chip-Seq_ESCs_Mouse1.51013959
77TP53_16413492_ChIP-PET_HCT116_Human1.50576832
78AR_21572438_ChIP-Seq_LNCaP_Human1.50301805
79STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.45939057
80TCF4_18268006_ChIP-ChIP_LS174T_Human1.43480476
81* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42620212
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.42160749
83* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40995937
84MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38843309
85* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38791081
86SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.36822043
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.36489989
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.36328668
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.36027967
90* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.35778935
91CREB1_26743006_Chip-Seq_LNCaP_Human1.35103308
92PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34675140
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.34355200
94MYC_19079543_ChIP-ChIP_MESCs_Mouse1.34251039
95* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34058633
96KDM5A_27292631_Chip-Seq_BREAST_Human1.33652910
97TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32859341
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.31317821
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30962516
100ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30564909
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.29817030
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29490389
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28584323
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28510650
105ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27849186
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24447476
107THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24330265
108ZFP281_27345836_Chip-Seq_ESCs_Mouse1.24243672
109* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23266378
110* ISL1_27105846_Chip-Seq_CPCs_Mouse1.23073632
111CHD1_26751641_Chip-Seq_LNCaP_Human1.21509917
112TET1_21451524_ChIP-Seq_MESCs_Mouse1.20661877
113RNF2_27304074_Chip-Seq_ESCs_Mouse1.20591748
114E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20481339
115TCF7_22412390_ChIP-Seq_EML_Mouse1.19590361
116RXR_22108803_ChIP-Seq_LS180_Human1.18269345
117STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17907528
118POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16746930
119DCP1A_22483619_ChIP-Seq_HELA_Human1.16697119
120* CBX2_27304074_Chip-Seq_ESCs_Mouse1.16317665
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.16153118
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16082906
123SA1_27219007_Chip-Seq_ERYTHROID_Human1.15604738
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15129800
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14896062
126SMC1_22415368_ChIP-Seq_MEFs_Mouse1.13045333
127* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12501874
128AHR_22903824_ChIP-Seq_MCF-7_Human1.12475510
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11590906
130* RING1B_27294783_Chip-Seq_NPCs_Mouse1.10370543
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10298542
132CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09003331
133* RNF2_27304074_Chip-Seq_NSC_Mouse1.08758670
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08378042
135ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07503356
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06367055
137TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06362191
138* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06145254
139TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04269667
140* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03684317
141* TP63_23658742_ChIP-Seq_EP156T_Human1.03627475
142* PIAS1_25552417_ChIP-Seq_VCAP_Human1.01955862
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01351084
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01351084
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01351084
146* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00686615
147* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00150842
148* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00137596
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.95687847
150P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95665174
151WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94952440
152* ELK3_25401928_ChIP-Seq_HUVEC_Human0.94742578
153* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.94333807
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.94302633
155KLF5_25053715_ChIP-Seq_YYC3_Human0.93080378
156* RING1B_27294783_Chip-Seq_ESCs_Mouse0.92281504
157* TBX20_22080862_ChIP-Seq_HEART_Mouse0.91773656
158* TBX20_22328084_ChIP-Seq_HEART_Mouse0.91773656
159* SA1_22415368_ChIP-Seq_MEFs_Mouse0.89493122
160* POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86408888
161* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85884797
162ATF3_27146783_Chip-Seq_COLON_Human0.85741435
163UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85325462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile4.52275398
2MP0008438_abnormal_cutaneous_collagen4.38655912
3MP0005503_abnormal_tendon_morphology3.33954988
4MP0003705_abnormal_hypodermis_morpholog3.05373059
5MP0010030_abnormal_orbit_morphology3.04143656
6MP0010234_abnormal_vibrissa_follicle3.00580974
7MP0005187_abnormal_penis_morphology2.85337374
8MP0010368_abnormal_lymphatic_system2.72260184
9MP0003941_abnormal_skin_development2.60992959
10MP0000678_abnormal_parathyroid_gland2.60078453
11MP0009384_cardiac_valve_regurgitation2.57159419
12MP0002796_impaired_skin_barrier2.50708982
13MP0009379_abnormal_foot_pigmentation2.46717466
14MP0001879_abnormal_lymphatic_vessel2.46629567
15* MP0004272_abnormal_basement_membrane2.34199901
16MP0003279_aneurysm2.29520810
17* MP0005623_abnormal_meninges_morphology2.27931192
18MP0002060_abnormal_skin_morphology2.24433988
19* MP0009250_abnormal_appendicular_skeleto2.18739151
20MP0003111_abnormal_nucleus_morphology2.17164488
21MP0000681_abnormal_thyroid_gland2.12603787
22MP0003693_abnormal_embryo_hatching2.09883436
23MP0003385_abnormal_body_wall2.00390994
24MP0003077_abnormal_cell_cycle1.91684924
25MP0000762_abnormal_tongue_morphology1.91610733
26MP0000003_abnormal_adipose_tissue1.87419089
27* MP0005508_abnormal_skeleton_morphology1.87264311
28* MP0002282_abnormal_trachea_morphology1.85712788
29MP0003315_abnormal_perineum_morphology1.84285177
30MP0006054_spinal_hemorrhage1.83070226
31MP0009053_abnormal_anal_canal1.82499167
32MP0000049_abnormal_middle_ear1.73458739
33MP0005501_abnormal_skin_physiology1.73251759
34MP0008932_abnormal_embryonic_tissue1.72565416
35MP0003566_abnormal_cell_adhesion1.71452115
36MP0000579_abnormal_nail_morphology1.70609613
37* MP0000163_abnormal_cartilage_morphology1.66474442
38* MP0002249_abnormal_larynx_morphology1.63930308
39MP0001958_emphysema1.61720998
40MP0010094_abnormal_chromosome_stability1.61556620
41MP0005409_darkened_coat_color1.60221090
42MP0004782_abnormal_surfactant_physiolog1.57881943
43MP0002896_abnormal_bone_mineralization1.56276694
44MP0003755_abnormal_palate_morphology1.54148127
45MP0002009_preneoplasia1.54018166
46* MP0002098_abnormal_vibrissa_morphology1.53231885
47MP0000377_abnormal_hair_follicle1.52348023
48MP0010352_gastrointestinal_tract_polyps1.51916243
49MP0000350_abnormal_cell_proliferation1.51660204
50MP0008057_abnormal_DNA_replication1.51569078
51MP0010678_abnormal_skin_adnexa1.48888950
52MP0002932_abnormal_joint_morphology1.48502764
53MP0002933_joint_inflammation1.47836899
54MP0000537_abnormal_urethra_morphology1.45138322
55MP0003937_abnormal_limbs/digits/tail_de1.44577044
56* MP0002115_abnormal_skeleton_extremities1.44437928
57MP0001188_hyperpigmentation1.44317984
58MP0002108_abnormal_muscle_morphology1.43101055
59MP0004185_abnormal_adipocyte_glucose1.41222254
60* MP0003942_abnormal_urinary_system1.35156126
61MP0000767_abnormal_smooth_muscle1.34176559
62MP0000534_abnormal_ureter_morphology1.31536989
63MP0005670_abnormal_white_adipose1.29804345
64MP0008007_abnormal_cellular_replicative1.29701382
65MP0004134_abnormal_chest_morphology1.26394866
66MP0010771_integument_phenotype1.26002108
67MP0005375_adipose_tissue_phenotype1.25771236
68MP0005023_abnormal_wound_healing1.25540426
69MP0000383_abnormal_hair_follicle1.24830215
70* MP0002085_abnormal_embryonic_tissue1.24220776
71* MP0003935_abnormal_craniofacial_develop1.24181039
72MP0004233_abnormal_muscle_weight1.23274282
73MP0001216_abnormal_epidermal_layer1.22766499
74MP0000647_abnormal_sebaceous_gland1.22660013
75MP0004957_abnormal_blastocyst_morpholog1.21998731
76* MP0002109_abnormal_limb_morphology1.21473985
77MP0001299_abnormal_eye_distance/1.20166364
78* MP0002113_abnormal_skeleton_development1.19428771
79MP0000428_abnormal_craniofacial_morphol1.17692342
80MP0000733_abnormal_muscle_development1.16360612
81* MP0002233_abnormal_nose_morphology1.16031737
82* MP0000432_abnormal_head_morphology1.14594211
83MP0010307_abnormal_tumor_latency1.14329688
84MP0001730_embryonic_growth_arrest1.13190329
85MP0001672_abnormal_embryogenesis/_devel1.13060720
86MP0005380_embryogenesis_phenotype1.13060720
87MP0001542_abnormal_bone_strength1.11736321
88MP0003453_abnormal_keratinocyte_physiol1.11195422
89* MP0002116_abnormal_craniofacial_bone1.11132655
90* MP0002092_abnormal_eye_morphology1.10726366
91MP0001243_abnormal_dermal_layer1.10373041
92MP0000427_abnormal_hair_cycle1.09863406
93MP0003984_embryonic_growth_retardation1.08987170
94* MP0005390_skeleton_phenotype1.07065253
95MP0002177_abnormal_outer_ear1.06033058
96MP0004381_abnormal_hair_follicle1.04507716
97MP0005171_absent_coat_pigmentation1.04329601
98MP0008961_abnormal_basal_metabolism1.03036569
99MP0004858_abnormal_nervous_system1.02973961
100MP0002088_abnormal_embryonic_growth/wei1.01452670
101MP0005257_abnormal_intraocular_pressure1.00095844
102MP0003283_abnormal_digestive_organ1.00024211
103MP0000467_abnormal_esophagus_morphology0.98277566
104MP0002295_abnormal_pulmonary_circulatio0.98118027
105* MP0002084_abnormal_developmental_patter0.97267808
106* MP0003091_abnormal_cell_migration0.96797829
107MP0002111_abnormal_tail_morphology0.95682741
108MP0002877_abnormal_melanocyte_morpholog0.93894907
109MP0005076_abnormal_cell_differentiation0.93366878
110MP0005248_abnormal_Harderian_gland0.92111878
111* MP0000516_abnormal_urinary_system0.88410224
112* MP0005367_renal/urinary_system_phenotyp0.88410224
113MP0003828_pulmonary_edema0.87717487
114* MP0001340_abnormal_eyelid_morphology0.86339579
115MP0002938_white_spotting0.84506930
116MP0002277_abnormal_respiratory_mucosa0.84391651
117* MP0002925_abnormal_cardiovascular_devel0.84283615
118MP0005666_abnormal_adipose_tissue0.83346938
119MP0008058_abnormal_DNA_repair0.82866220
120* MP0002160_abnormal_reproductive_system0.82542377
121MP0002127_abnormal_cardiovascular_syste0.81704079
122MP0003938_abnormal_ear_development0.81432718
123MP0003943_abnormal_hepatobiliary_system0.81033159
124MP0006138_congestive_heart_failure0.80764973
125MP0000759_abnormal_skeletal_muscle0.80541430
126MP0002163_abnormal_gland_morphology0.79819808
127* MP0001697_abnormal_embryo_size0.79506175
128* MP0002080_prenatal_lethality0.79015182
129* MP0002114_abnormal_axial_skeleton0.77743452
130MP0005167_abnormal_blood-brain_barrier0.75755622
131* MP0001614_abnormal_blood_vessel0.75053782
132* MP0001784_abnormal_fluid_regulation0.74577123
133MP0002234_abnormal_pharynx_morphology0.74044666
134MP0000566_synostosis0.73990216
135* MP0002697_abnormal_eye_size0.73914710
136* MP0002128_abnormal_blood_circulation0.72869499
137MP0003795_abnormal_bone_structure0.72795104
138MP0002254_reproductive_system_inflammat0.72654769
139MP0002998_abnormal_bone_remodeling0.71983671
140* MP0005193_abnormal_anterior_eye0.71829748
141MP0001270_distended_abdomen0.71410141
142* MP0001286_abnormal_eye_development0.71098985
143MP0003115_abnormal_respiratory_system0.70936768
144MP0001849_ear_inflammation0.70566884

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)5.83253257
2Premature rupture of membranes (HP:0001788)5.26529884
3Protrusio acetabuli (HP:0003179)5.17205935
4Abnormality of the phalanges of the hallux (HP:0010057)5.10940960
5Abnormality of the fetal cardiovascular system (HP:0010948)4.65415486
6Abnormal umbilical cord blood vessels (HP:0011403)4.65415486
7Single umbilical artery (HP:0001195)4.65415486
8Neonatal short-limb short stature (HP:0008921)4.34493507
9Transposition of the great arteries (HP:0001669)4.15210867
10Abnormal connection of the cardiac segments (HP:0011545)4.15210867
11Abnormal ventriculo-arterial connection (HP:0011563)4.15210867
12Broad distal phalanx of finger (HP:0009836)4.09591795
13Epiphyseal dysplasia (HP:0002656)4.07152781
14Congenital malformation of the right heart (HP:0011723)4.02658407
15Double outlet right ventricle (HP:0001719)4.02658407
16Short middle phalanx of the 5th finger (HP:0004220)3.83301266
17Abnormality of the distal phalanx of the thumb (HP:0009617)3.55931146
18Abnormality of the aortic arch (HP:0012303)3.47583874
19Hypoplastic ischia (HP:0003175)3.35081859
20Abnormal number of incisors (HP:0011064)3.31785176
21Periauricular skin pits (HP:0100277)3.30989733
22Preauricular pit (HP:0004467)3.30989733
23Atrophic scars (HP:0001075)3.30464720
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.29985405
25Shallow orbits (HP:0000586)3.25567149
26Abnormality of the umbilical cord (HP:0010881)3.24922524
27Aortic dissection (HP:0002647)3.17772052
28Soft skin (HP:0000977)3.03044980
29Abnormality of the ischium (HP:0003174)2.93242567
30Cupped ribs (HP:0000887)2.91850818
31Cervical subluxation (HP:0003308)2.90853201
32Abnormality of the parietal bone (HP:0002696)2.89495824
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.88061294
34Vitreoretinal degeneration (HP:0000655)2.87137297
35Abnormality of the 4th metacarpal (HP:0010012)2.87124353
36Renal dysplasia (HP:0000110)2.84789402
37Short 5th finger (HP:0009237)2.77364767
38Abnormality of the 2nd finger (HP:0004100)2.77344008
39Ankle contracture (HP:0006466)2.77329870
40Fragile skin (HP:0001030)2.74575835
41Abnormality of dentin (HP:0010299)2.70471218
42Follicular hyperkeratosis (HP:0007502)2.70233703
43Truncus arteriosus (HP:0001660)2.68258008
44Skin pits (HP:0100276)2.67959698
45Birth length less than 3rd percentile (HP:0003561)2.63701132
46Irregular epiphyses (HP:0010582)2.62399453
47Hypoplastic left heart (HP:0004383)2.60534202
48Intestinal fistula (HP:0100819)2.55048314
49Abnormality of the phalanges of the 2nd finger (HP:0009541)2.54023031
50Bifid scrotum (HP:0000048)2.51721977
51Unilateral renal agenesis (HP:0000122)2.51684560
52Aortic aneurysm (HP:0004942)2.51432156
53Delayed epiphyseal ossification (HP:0002663)2.49497730
54Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.48541906
55Broad metatarsal (HP:0001783)2.46128602
56Rectal fistula (HP:0100590)2.45893480
57Rectovaginal fistula (HP:0000143)2.45893480
58Small epiphyses (HP:0010585)2.44478327
59Down-sloping shoulders (HP:0200021)2.43989997
60Mitral valve prolapse (HP:0001634)2.43170198
61Partial duplication of the phalanx of hand (HP:0009999)2.40760943
62Mild short stature (HP:0003502)2.39758863
63Natal tooth (HP:0000695)2.39281880
64Short clavicles (HP:0000894)2.39219251
65Ureteral stenosis (HP:0000071)2.39181438
66Hip contracture (HP:0003273)2.36970210
67Lip pit (HP:0100267)2.36889588
68Overgrowth (HP:0001548)2.35720599
69Genu recurvatum (HP:0002816)2.35199483
70Limited hip movement (HP:0008800)2.35180644
71Esophageal atresia (HP:0002032)2.34830184
72Hypotrichosis (HP:0001006)2.34515054
73Wormian bones (HP:0002645)2.32537474
74Mesomelia (HP:0003027)2.32146829
75Abnormality of chromosome segregation (HP:0002916)2.30832063
76Woolly hair (HP:0002224)2.28526974
77Breast hypoplasia (HP:0003187)2.26445656
78Osteoarthritis (HP:0002758)2.25185111
79Vascular tortuosity (HP:0004948)2.24842425
80Abnormal vertebral ossification (HP:0100569)2.24443842
81Peritonitis (HP:0002586)2.22034184
82Vaginal fistula (HP:0004320)2.21298317
83Spinal rigidity (HP:0003306)2.21262572
84Blue sclerae (HP:0000592)2.19320887
85Spinal cord lesions (HP:0100561)2.17820862
86Syringomyelia (HP:0003396)2.17820862
87Short hallux (HP:0010109)2.17513864
88Progressive muscle weakness (HP:0003323)2.17333283
89Anal stenosis (HP:0002025)2.16857964
90Ureteral obstruction (HP:0006000)2.16505326
91Aplasia/Hypoplasia of the clavicles (HP:0006710)2.15376917
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.13734299
93Preaxial foot polydactyly (HP:0001841)2.13267737
94Abnormality of the columella (HP:0009929)2.10443214
95Abnormality of carpal bone ossification (HP:0006257)2.10100307
96Preauricular skin tag (HP:0000384)2.09510315
97Bladder diverticulum (HP:0000015)2.08968769
98Coronal craniosynostosis (HP:0004440)2.07314443
99Spinal cord compression (HP:0002176)2.06997361
100Abnormal tarsal ossification (HP:0008369)2.05990174
101Tibial bowing (HP:0002982)2.05313543
102Metaphyseal dysplasia (HP:0100255)2.04769136
103Proximal placement of thumb (HP:0009623)2.04735598
104Dilatation of the ascending aorta (HP:0005111)2.04506259
105Bowed forearm bones (HP:0003956)2.04107260
106Bowing of the arm (HP:0006488)2.04107260
107Wide anterior fontanel (HP:0000260)2.02387030
108Arterial tortuosity (HP:0005116)2.01525962
109Nasolacrimal duct obstruction (HP:0000579)2.01280779
110Onycholysis (HP:0001806)2.01251168
111Advanced eruption of teeth (HP:0006288)2.01110749
112Right ventricular cardiomyopathy (HP:0011663)2.00762628
113Ectopic kidney (HP:0000086)2.00110854
114Genu varum (HP:0002970)2.00109990
115Coxa vara (HP:0002812)1.99833403
116Flat acetabular roof (HP:0003180)1.98778757
117Skin tags (HP:0010609)1.98404330
118Hypoplastic heart (HP:0001961)1.97994022
119Abnormality of the radial head (HP:0003995)1.97770240
120Congenital, generalized hypertrichosis (HP:0004540)1.96991141
121Germ cell neoplasia (HP:0100728)1.96814693
122Deviation of the thumb (HP:0009603)1.96591282
123High anterior hairline (HP:0009890)1.96539234
124Pulmonary artery stenosis (HP:0004415)1.96274970
125Flat capital femoral epiphysis (HP:0003370)1.96229585
126Long eyelashes (HP:0000527)1.95515787
127Hallux valgus (HP:0001822)1.95185921
128Exostoses (HP:0100777)1.95044301
129Abnormal ossification of hand bones (HP:0005921)1.94963133
130Aplasia cutis congenita (HP:0001057)1.94369262
131Biconcave vertebral bodies (HP:0004586)1.94193863
132Aplasia/Hypoplasia of the hallux (HP:0008362)1.94065124
133Short middle phalanx of finger (HP:0005819)1.94029825
134Atresia of the external auditory canal (HP:0000413)1.93316704
135Platyspondyly (HP:0000926)1.93216251
136Metaphyseal cupping (HP:0003021)1.92943370
137Cerebral aneurysm (HP:0004944)1.92352200
138Cutaneous melanoma (HP:0012056)1.91212706
139Dislocated radial head (HP:0003083)1.90668763
140Absent radius (HP:0003974)1.90576384
141Persistence of primary teeth (HP:0006335)1.90268328
142Occipital encephalocele (HP:0002085)1.89141424
143Venous insufficiency (HP:0005293)1.89036171
144Midline defect of the nose (HP:0004122)1.88640135
145Absent phalangeal crease (HP:0006109)1.87763080
146Abnormality of the middle phalanges of the toes (HP:0010183)1.86359082
147Short thumb (HP:0009778)1.86174644
148Short nail (HP:0001799)1.86069920
149Abnormality of the distal phalanges of the toes (HP:0010182)1.85783688
150Abnormality of the intervertebral disk (HP:0005108)1.85562214
151Glossoptosis (HP:0000162)1.85450786
152Concave nail (HP:0001598)1.84888808
153Elbow flexion contracture (HP:0002987)1.84867676
154Obstructive sleep apnea (HP:0002870)1.84439931
155Broad long bones (HP:0005622)1.84178434
156Ulnar bowing (HP:0003031)1.84169764
157Venous abnormality (HP:0002624)1.84049635
158Hyperextensible skin (HP:0000974)1.83610482
159Abnormality of the incisor (HP:0000676)1.83220800
160Increased connective tissue (HP:0009025)1.83123713
161Partial duplication of thumb phalanx (HP:0009944)1.82157118
162Carpal synostosis (HP:0009702)1.81982763
163Abnormal foot bone ossification (HP:0010675)1.80807734
164Knee flexion contracture (HP:0006380)1.78948191
165Type 1 muscle fiber predominance (HP:0003803)1.78904640
166Abnormalities of placenta or umbilical cord (HP:0001194)1.78240600
167Selective tooth agenesis (HP:0001592)1.78231108
168Vesicoureteral reflux (HP:0000076)1.78136397
169Oligodontia (HP:0000677)1.78006140
170Radial bowing (HP:0002986)1.77866035
171Abnormality of the acetabulum (HP:0003170)1.76904960
172Broad thumb (HP:0011304)1.76879020
173Abnormality of the phalanges of the 5th finger (HP:0004213)1.76790346
174Fragile nails (HP:0001808)1.75576140
175Abnormal hand bone ossification (HP:0010660)1.75499610
176Limited elbow extension (HP:0001377)1.75439908
177Abnormality of the frontal sinuses (HP:0002687)1.75054762
178Aplasia involving forearm bones (HP:0009822)1.74869360
179Absent forearm bone (HP:0003953)1.74869360
180Severe Myopia (HP:0011003)1.74382363
181Deviation of the hallux (HP:0010051)1.74013570
182Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.73817730
183Trismus (HP:0000211)1.73655021
184Scapular winging (HP:0003691)1.73536527
185Mitral regurgitation (HP:0001653)1.72866992
186Broad ribs (HP:0000885)1.72756831
187Sensory axonal neuropathy (HP:0003390)1.72622624
188Tracheomalacia (HP:0002779)1.72394976
189Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.72190895
190Urethral obstruction (HP:0000796)1.70962230
191Radioulnar synostosis (HP:0002974)1.70199294
192Microretrognathia (HP:0000308)1.67106706

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.14214994
2DDR24.82787863
3EPHB24.51663671
4LATS14.04807808
5MAPK153.60759160
6SMG12.96643587
7FER2.91911418
8BRD42.61965356
9PDGFRA2.55707471
10ICK2.51949295
11TRPM72.38159210
12TGFBR12.34108902
13IRAK32.24409624
14TIE12.20139960
15TGFBR22.12259713
16TTN2.04197113
17NUAK12.00369539
18MST1R1.97998237
19KDR1.92592401
20CAMK1G1.92379176
21BUB11.90354247
22MAP3K31.76913922
23STK31.75607948
24MST41.75153256
25LRRK21.74698138
26CAMK1D1.72355194
27ERBB31.70975610
28LATS21.69990430
29TRIM281.64126286
30CDC71.61764994
31NLK1.60855677
32FRK1.57808212
33MET1.56849085
34STK38L1.54133963
35EEF2K1.52294342
36CHEK21.51475033
37EPHA31.51239767
38SIK11.48265424
39PNCK1.46756725
40PAK21.43101148
41PRPF4B1.42187006
42TRIB31.40473721
43BMX1.34417375
44CDK71.30327685
45NME21.29539109
46PRKG21.27425868
47PTK21.27302503
48DMPK1.25022241
49NEK91.24989919
50WNK41.19766775
51PTK61.19386961
52PTK2B1.19028545
53PKN21.13193422
54STK41.11900719
55GRK11.11211510
56FGFR21.09512431
57CHEK11.05357779
58AKT21.05141076
59IRAK21.04744334
60ROCK11.01958951
61PIK3CA1.01725507
62PAK41.01701531
63ATR1.00545842
64BCR0.99182695
65AKT30.98781843
66RPS6KB20.97721882
67TAOK20.97191045
68MAP2K30.96207712
69WEE10.95302919
70DYRK30.94899861
71CDK40.94142231
72PDGFRB0.92205613
73PAK30.91538760
74AURKA0.90550714
75CDK30.89306605
76RPS6KA40.89280126
77RIPK10.88397361
78MAP3K20.88175153
79FGFR10.86778531
80MKNK10.86411045
81KSR20.85190855
82BRAF0.83237761
83PIM20.80781772
84WNK10.80780484
85FGFR30.79965648
86STK240.79659689
87CDK60.78827162
88ERN10.78680709
89TTK0.76177017
90RPS6KL10.75292652
91RPS6KC10.75292652
92MAPKAPK30.74442828
93CSNK1G30.70804583
94PRKD10.67857464
95* CDK20.66616333
96STK390.66120361
97BRSK10.65903538
98STK100.65895460
99RPS6KA60.65733083
100EPHA20.62252047
101MKNK20.61737403
102PRKD20.61234835
103RAF10.61073792
104RPS6KA10.60999260
105AURKB0.57094405
106DYRK1B0.56505956
107MAPKAPK50.55277487
108PRKCE0.54817589
109EPHB10.54735640
110MAP3K10.54604175
111ABL20.54349618
112PRKD30.53868527
113TSSK60.53702393
114PLK10.52850557
115ARAF0.52703168
116GSK3A0.52216406
117INSR0.52053531
118MAP3K80.52003845
119CDK80.51482954
120ATM0.50359120
121PLK20.50207964
122YES10.50164369
123IGF1R0.49151871
124MAPK140.48627691
125CDK10.48589478
126PIM10.48536987
127MUSK0.48278780
128ADRBK10.48174031
129MAPK110.47383882
130BMPR1B0.47039931
131ROCK20.46970011
132CDK90.46925316
133SRPK10.46808924
134MAP3K100.46663193
135MOS0.45768416
136MELK0.44001379
137PRKAA10.43601416
138RPS6KA50.43277147
139TAOK10.42393761
140ABL10.41385056
141EIF2AK20.41059075
142ILK0.41058441
143PLK40.40856204
144SRC0.38989843
145RPS6KA20.38357261
146CAMK40.38127755
147GSK3B0.37108310
148MAP2K10.36362133
149NEK20.36171167
150MAPK100.36034090
151CSNK1G10.35916077
152MYLK0.35734537
153MAP2K20.35023765
154AKT10.33543036
155MTOR0.33377394
156PRKCH0.31828473
157STK110.31718031
158CSNK1A1L0.29376987
159PRKAA20.28924054
160HIPK20.28704976
161MAPK120.28218270
162RET0.28050749
163TLK10.26159680

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.19365642
2Sulfur relay system_Homo sapiens_hsa041223.67285822
3Focal adhesion_Homo sapiens_hsa045102.79017002
4DNA replication_Homo sapiens_hsa030302.59491225
5Adherens junction_Homo sapiens_hsa045202.55772353
6Basal cell carcinoma_Homo sapiens_hsa052172.54087677
7Protein digestion and absorption_Homo sapiens_hsa049742.51563509
8Ribosome_Homo sapiens_hsa030102.49615726
9TGF-beta signaling pathway_Homo sapiens_hsa043502.47626706
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.36281156
11Proteoglycans in cancer_Homo sapiens_hsa052052.29043187
12Hippo signaling pathway_Homo sapiens_hsa043902.26682494
13Spliceosome_Homo sapiens_hsa030402.12929707
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.09073689
15Hedgehog signaling pathway_Homo sapiens_hsa043402.03731044
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.95380573
17MicroRNAs in cancer_Homo sapiens_hsa052061.92498191
18Small cell lung cancer_Homo sapiens_hsa052221.90374651
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.70286632
20Vitamin B6 metabolism_Homo sapiens_hsa007501.69140924
21Axon guidance_Homo sapiens_hsa043601.67324515
22Malaria_Homo sapiens_hsa051441.64733592
23Lysine degradation_Homo sapiens_hsa003101.64087576
24Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.63655729
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62396204
26Melanoma_Homo sapiens_hsa052181.56875809
27Tight junction_Homo sapiens_hsa045301.56745743
28Bladder cancer_Homo sapiens_hsa052191.55810185
29Amoebiasis_Homo sapiens_hsa051461.55622367
30RNA transport_Homo sapiens_hsa030131.55307210
31Wnt signaling pathway_Homo sapiens_hsa043101.53046867
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.51741101
33mRNA surveillance pathway_Homo sapiens_hsa030151.51338134
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.46085366
35Melanogenesis_Homo sapiens_hsa049161.44877661
36Prostate cancer_Homo sapiens_hsa052151.39615347
37Dilated cardiomyopathy_Homo sapiens_hsa054141.36010699
38Rap1 signaling pathway_Homo sapiens_hsa040151.35537785
39Pathways in cancer_Homo sapiens_hsa052001.32119354
40One carbon pool by folate_Homo sapiens_hsa006701.30534740
41RNA polymerase_Homo sapiens_hsa030201.28598664
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26783933
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23565131
44Base excision repair_Homo sapiens_hsa034101.23538181
45Chronic myeloid leukemia_Homo sapiens_hsa052201.23474795
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22663196
47Glioma_Homo sapiens_hsa052141.18450969
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12874428
49Sphingolipid metabolism_Homo sapiens_hsa006001.11973755
50Renal cell carcinoma_Homo sapiens_hsa052111.10848349
51Platelet activation_Homo sapiens_hsa046111.09691860
52Pyrimidine metabolism_Homo sapiens_hsa002401.09326900
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.08993888
54p53 signaling pathway_Homo sapiens_hsa041151.08407036
55HTLV-I infection_Homo sapiens_hsa051661.06175019
56Ras signaling pathway_Homo sapiens_hsa040141.05547527
57AMPK signaling pathway_Homo sapiens_hsa041521.04273306
58Homologous recombination_Homo sapiens_hsa034401.01356235
59Notch signaling pathway_Homo sapiens_hsa043301.00088728
60Prion diseases_Homo sapiens_hsa050200.99851803
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.99699446
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97382091
63Pancreatic cancer_Homo sapiens_hsa052120.96429391
64Mismatch repair_Homo sapiens_hsa034300.93435671
65HIF-1 signaling pathway_Homo sapiens_hsa040660.93303211
66mTOR signaling pathway_Homo sapiens_hsa041500.92663308
67Thyroid cancer_Homo sapiens_hsa052160.90223185
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89793722
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89549541
70Circadian rhythm_Homo sapiens_hsa047100.89313938
71Nucleotide excision repair_Homo sapiens_hsa034200.84770148
72Insulin signaling pathway_Homo sapiens_hsa049100.84487861
73Folate biosynthesis_Homo sapiens_hsa007900.82676668
74Endometrial cancer_Homo sapiens_hsa052130.77860545
75Colorectal cancer_Homo sapiens_hsa052100.77213685
76VEGF signaling pathway_Homo sapiens_hsa043700.76561394
77Fanconi anemia pathway_Homo sapiens_hsa034600.76227634
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.75710843
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75542402
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74537233
81Estrogen signaling pathway_Homo sapiens_hsa049150.74529662
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73816997
83Viral myocarditis_Homo sapiens_hsa054160.73434534
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72291232
85TNF signaling pathway_Homo sapiens_hsa046680.69416779
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69230200
87Ovarian steroidogenesis_Homo sapiens_hsa049130.69096786
88Toxoplasmosis_Homo sapiens_hsa051450.67148546
89FoxO signaling pathway_Homo sapiens_hsa040680.66541952
90Basal transcription factors_Homo sapiens_hsa030220.66177102
91Dorso-ventral axis formation_Homo sapiens_hsa043200.63830363
92Gap junction_Homo sapiens_hsa045400.62708447
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59909865
94ErbB signaling pathway_Homo sapiens_hsa040120.58631209
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57582198
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57328238
97Hepatitis B_Homo sapiens_hsa051610.57117358
98Biosynthesis of amino acids_Homo sapiens_hsa012300.55682986
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.55533109
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53531707
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.53099409
102GnRH signaling pathway_Homo sapiens_hsa049120.51896996
103Glucagon signaling pathway_Homo sapiens_hsa049220.51709945
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.51511850
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.50488261
106Purine metabolism_Homo sapiens_hsa002300.49802421
107Phenylalanine metabolism_Homo sapiens_hsa003600.49090209
108Selenocompound metabolism_Homo sapiens_hsa004500.48483459
109Acute myeloid leukemia_Homo sapiens_hsa052210.48393352
110Shigellosis_Homo sapiens_hsa051310.48325166
111Non-homologous end-joining_Homo sapiens_hsa034500.47951388
112Endocytosis_Homo sapiens_hsa041440.46982805
113Viral carcinogenesis_Homo sapiens_hsa052030.46730456
114Cell cycle_Homo sapiens_hsa041100.45993873
115Apoptosis_Homo sapiens_hsa042100.45615287
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44559520
117Oxytocin signaling pathway_Homo sapiens_hsa049210.43531203
118Jak-STAT signaling pathway_Homo sapiens_hsa046300.42257246
119Oocyte meiosis_Homo sapiens_hsa041140.41240865
120MAPK signaling pathway_Homo sapiens_hsa040100.40964506
121Choline metabolism in cancer_Homo sapiens_hsa052310.40312244
122Long-term depression_Homo sapiens_hsa047300.40004250
123Inositol phosphate metabolism_Homo sapiens_hsa005620.39892247
124Salmonella infection_Homo sapiens_hsa051320.38788419
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38769807
126RNA degradation_Homo sapiens_hsa030180.38536129
127Renin-angiotensin system_Homo sapiens_hsa046140.38286829
128Alcoholism_Homo sapiens_hsa050340.37263355
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36068421
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35956795
131Non-small cell lung cancer_Homo sapiens_hsa052230.34897039
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34359976
133Insulin resistance_Homo sapiens_hsa049310.34276875
134Arachidonic acid metabolism_Homo sapiens_hsa005900.33880628
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.33745811
136Hepatitis C_Homo sapiens_hsa051600.33286731
137Protein export_Homo sapiens_hsa030600.33147143
138Mineral absorption_Homo sapiens_hsa049780.30101131

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