FOXB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.77662496
2translational termination (GO:0006415)7.37316733
3ribosomal small subunit assembly (GO:0000028)6.47511444
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.18538533
5cotranslational protein targeting to membrane (GO:0006613)6.12892949
6protein targeting to ER (GO:0045047)6.00433600
7forebrain neuron differentiation (GO:0021879)5.97850825
8translational elongation (GO:0006414)5.96052872
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.75762876
10maturation of SSU-rRNA (GO:0030490)5.73995593
11cellular protein complex disassembly (GO:0043624)5.70305959
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.67061004
13protein localization to endoplasmic reticulum (GO:0070972)5.54502942
14viral life cycle (GO:0019058)5.48977253
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.46855498
16pyrimidine nucleobase catabolic process (GO:0006208)5.34677637
17ribosomal small subunit biogenesis (GO:0042274)5.20713398
18cellular potassium ion homeostasis (GO:0030007)5.13827240
19protein complex disassembly (GO:0043241)4.97170816
20translational initiation (GO:0006413)4.92927366
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.81272709
22ATP synthesis coupled proton transport (GO:0015986)4.81272709
23regulation of respiratory system process (GO:0044065)4.73157684
24membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.67161882
25macromolecular complex disassembly (GO:0032984)4.62618649
26cell proliferation in forebrain (GO:0021846)4.61798897
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.61431365
28negative regulation of axon extension involved in axon guidance (GO:0048843)4.59375870
29regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.57580909
30negative regulation of cytosolic calcium ion concentration (GO:0051481)4.55161180
31G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.51449783
32negative regulation of axon guidance (GO:1902668)4.51069075
33neuron cell-cell adhesion (GO:0007158)4.50929918
34neurotransmitter uptake (GO:0001504)4.40161370
35forebrain neuron development (GO:0021884)4.29344186
36ribosomal large subunit biogenesis (GO:0042273)4.25044600
37facial nerve structural organization (GO:0021612)4.19189171
38sodium ion export (GO:0071436)4.17916770
39cranial nerve structural organization (GO:0021604)4.12230040
40regulation of respiratory gaseous exchange (GO:0043576)4.05387194
41nuclear-transcribed mRNA catabolic process (GO:0000956)4.04480327
42protein targeting to membrane (GO:0006612)4.02372527
43central nervous system neuron development (GO:0021954)3.92884760
44left/right axis specification (GO:0070986)3.89433811
45mRNA catabolic process (GO:0006402)3.88226331
46cranial nerve morphogenesis (GO:0021602)3.84216686
47nucleobase catabolic process (GO:0046113)3.80734505
48gamma-aminobutyric acid transport (GO:0015812)3.76096311
49cellular sodium ion homeostasis (GO:0006883)3.75802896
50regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.75076983
51cell communication by electrical coupling (GO:0010644)3.75051381
52axonal fasciculation (GO:0007413)3.73882444
53positive regulation of synapse assembly (GO:0051965)3.70979021
54drinking behavior (GO:0042756)3.70825504
55atrial cardiac muscle cell action potential (GO:0086014)3.69448729
56lateral sprouting from an epithelium (GO:0060601)3.67535856
57positive regulation of gastrulation (GO:2000543)3.67258348
58regulation of cardiac muscle cell contraction (GO:0086004)3.66886259
59auditory behavior (GO:0031223)3.65187783
60cerebral cortex radially oriented cell migration (GO:0021799)3.63820660
61calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.63138576
62neuronal stem cell maintenance (GO:0097150)3.62793888
63somite development (GO:0061053)3.59687012
64behavioral response to nicotine (GO:0035095)3.59278730
65primitive streak formation (GO:0090009)3.56438092
66RNA catabolic process (GO:0006401)3.51998776
67* midbrain development (GO:0030901)3.50385609
68otic vesicle formation (GO:0030916)3.49127710
69serine family amino acid catabolic process (GO:0009071)3.47752744
70spinal cord association neuron differentiation (GO:0021527)3.46149743
71response to auditory stimulus (GO:0010996)3.45475866
72retina layer formation (GO:0010842)3.41459125
73chromatin remodeling at centromere (GO:0031055)3.39962784
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.39556850
75cell migration involved in heart development (GO:0060973)3.38855978
76translation (GO:0006412)3.37077077
77potassium ion homeostasis (GO:0055075)3.36229102
78negative regulation of axon extension (GO:0030517)3.34222984
79postsynaptic membrane organization (GO:0001941)3.34055240
80anatomical structure arrangement (GO:0048532)3.32738270
81neuron recognition (GO:0008038)3.30035204
82regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27848283
83CENP-A containing nucleosome assembly (GO:0034080)3.27055348
84DNA ligation (GO:0006266)3.24284460
85mitochondrial respiratory chain complex I assembly (GO:0032981)3.23758253
86NADH dehydrogenase complex assembly (GO:0010257)3.23758253
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23758253
88regulation of short-term neuronal synaptic plasticity (GO:0048172)3.23224173
89cerebellar granule cell differentiation (GO:0021707)3.22397567
90respiratory electron transport chain (GO:0022904)3.20489041
91regulation of axon guidance (GO:1902667)3.19112114
92phosphorelay signal transduction system (GO:0000160)3.17682254
93electron transport chain (GO:0022900)3.14648506
94inner mitochondrial membrane organization (GO:0007007)3.11043348
95mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.09846842
96neuron fate determination (GO:0048664)3.06506554
97regulation of axon extension involved in axon guidance (GO:0048841)3.06501930
98regulation of synapse assembly (GO:0051963)3.06085804
99presynaptic membrane assembly (GO:0097105)3.05715238
100central nervous system projection neuron axonogenesis (GO:0021952)3.04912900
101central nervous system myelination (GO:0022010)3.03023144
102axon ensheathment in central nervous system (GO:0032291)3.03023144
103establishment of tissue polarity (GO:0007164)3.02278116
104establishment of planar polarity (GO:0001736)3.02278116
105RNA localization (GO:0006403)2.99758710
106dopaminergic neuron differentiation (GO:0071542)2.96268728
107negative regulation of sodium ion transport (GO:0010766)2.92468775
108negative regulation of DNA-templated transcription, elongation (GO:0032785)2.91449006
109negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.91449006
110protein complex biogenesis (GO:0070271)2.88373708
111vocalization behavior (GO:0071625)2.87107287
112protein localization to synapse (GO:0035418)2.86765081
113heparin metabolic process (GO:0030202)2.86259814
114heparin biosynthetic process (GO:0030210)2.86259814
115response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.86226563
116regulation of mesenchymal cell apoptotic process (GO:2001053)2.85528574
117nonmotile primary cilium assembly (GO:0035058)2.84473212
118ventricular cardiac muscle cell development (GO:0055015)2.83591860
119somite rostral/caudal axis specification (GO:0032525)2.83166788
120regulation of activation of Janus kinase activity (GO:0010533)2.81655901
121membrane hyperpolarization (GO:0060081)2.81524370
122negative regulation of smoothened signaling pathway (GO:0045879)2.81375701
123regulation of actin filament-based movement (GO:1903115)2.81341758
124lung-associated mesenchyme development (GO:0060484)2.81098484
125regulation of posttranscriptional gene silencing (GO:0060147)2.79924022
126regulation of gene silencing by miRNA (GO:0060964)2.79924022
127regulation of gene silencing by RNA (GO:0060966)2.79924022
128chaperone-mediated protein transport (GO:0072321)2.79653932
129motor neuron axon guidance (GO:0008045)2.78934228
130histone arginine methylation (GO:0034969)2.78880493
131outer ear morphogenesis (GO:0042473)2.77702637
132potassium ion import (GO:0010107)2.77659675
133DNA replication checkpoint (GO:0000076)2.76995830
134hindlimb morphogenesis (GO:0035137)2.76542289
135negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75065987
136mechanosensory behavior (GO:0007638)2.75032601
137negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74564465
138DNA damage response, detection of DNA damage (GO:0042769)2.74459572
139radial glial cell differentiation (GO:0060019)2.74182658
140ATP biosynthetic process (GO:0006754)2.74130809
141generation of neurons (GO:0048699)2.73901022
142negative chemotaxis (GO:0050919)2.71744635
143mitochondrial respiratory chain complex assembly (GO:0033108)2.71366202
144positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.71176645
145glycine metabolic process (GO:0006544)2.70586309
146anterior/posterior axis specification, embryo (GO:0008595)2.70566529
147histone exchange (GO:0043486)2.70355567
148presynaptic membrane organization (GO:0097090)2.70158300
149neuron migration (GO:0001764)2.70080762
150sequestering of actin monomers (GO:0042989)2.69285095
151hindbrain development (GO:0030902)2.68416950
152female gonad development (GO:0008585)2.67740779
153establishment of protein localization to membrane (GO:0090150)2.67661613
154retinal ganglion cell axon guidance (GO:0031290)2.66995757
155spliceosomal complex assembly (GO:0000245)2.66544856
156regulation of synapse organization (GO:0050807)2.65044721
157positive regulation of neurological system process (GO:0031646)2.65005916
158dendrite morphogenesis (GO:0048813)2.63757602
159positive regulation of action potential (GO:0045760)2.63301549
160cranial nerve development (GO:0021545)2.62875001
161regulation of timing of cell differentiation (GO:0048505)2.62274114
162nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.61668809
163microtubule depolymerization (GO:0007019)2.61336113
164sodium ion homeostasis (GO:0055078)2.61296729
165L-amino acid import (GO:0043092)2.60856131
166protein neddylation (GO:0045116)2.60774309
167intracellular protein transmembrane import (GO:0044743)2.60576869
168ribonucleoprotein complex biogenesis (GO:0022613)2.60116597
169mRNA splice site selection (GO:0006376)2.59853064
170limb bud formation (GO:0060174)2.59108522
171negative regulation of microtubule polymerization (GO:0031115)2.58574080
172hippocampus development (GO:0021766)2.57741412
173cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.56064770
174embryonic hindlimb morphogenesis (GO:0035116)2.56010194
175synapsis (GO:0007129)2.54710564
176establishment of protein localization to organelle (GO:0072594)2.49923728
177exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49564426
178DNA replication-independent nucleosome organization (GO:0034724)2.49314644
179DNA replication-independent nucleosome assembly (GO:0006336)2.49314644
180spliceosomal snRNP assembly (GO:0000387)2.49173327
181cellular component biogenesis (GO:0044085)2.48658708
182regulation of non-canonical Wnt signaling pathway (GO:2000050)2.46427625
183protein targeting (GO:0006605)2.46215169
184purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.45168736
185epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.44874084
186purine nucleoside triphosphate biosynthetic process (GO:0009145)2.43650709
187pituitary gland development (GO:0021983)2.43369180
188negative regulation of glial cell differentiation (GO:0045686)2.41926899
189ventricular septum development (GO:0003281)2.41417283
190positive regulation of oligodendrocyte differentiation (GO:0048714)2.40594931
191centriole replication (GO:0007099)2.40472282
192embryonic axis specification (GO:0000578)2.39353524
193tongue development (GO:0043586)2.39138059
194response to pheromone (GO:0019236)11.9524520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.04134398
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.08908666
3GBX2_23144817_ChIP-Seq_PC3_Human4.07558304
4E2F7_22180533_ChIP-Seq_HELA_Human3.89839840
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.84043402
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.56767183
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.29410079
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.26971906
9* EZH2_27304074_Chip-Seq_ESCs_Mouse3.07950533
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07288814
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.90830344
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87371697
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.87052067
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84748717
15* CBX2_27304074_Chip-Seq_ESCs_Mouse2.80338206
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75865499
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.74416057
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73291090
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.71190749
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.68227313
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.55148632
22* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.52820074
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47891600
24CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45358518
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37136413
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.36029290
27* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35635458
28* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35148024
29* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34732780
30* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33487046
31* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33487046
32* RNF2_27304074_Chip-Seq_NSC_Mouse2.29267740
33* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28198945
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23052140
35FUS_26573619_Chip-Seq_HEK293_Human2.22820118
36TAF15_26573619_Chip-Seq_HEK293_Human2.22141363
37* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15163879
38XRN2_22483619_ChIP-Seq_HELA_Human2.12041983
39TTF2_22483619_ChIP-Seq_HELA_Human2.10072432
40ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05029613
41MYC_18940864_ChIP-ChIP_HL60_Human2.04047943
42CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02494535
43RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.01900795
44ETS1_20019798_ChIP-Seq_JURKAT_Human2.01846548
45* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99214810
46* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99180346
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96369060
48* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.95829347
49AR_21572438_ChIP-Seq_LNCaP_Human1.94370938
50PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92595723
51* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89490093
52ELK1_19687146_ChIP-ChIP_HELA_Human1.88224142
53* REST_21632747_ChIP-Seq_MESCs_Mouse1.86523086
54EWS_26573619_Chip-Seq_HEK293_Human1.81403210
55ZNF274_21170338_ChIP-Seq_K562_Hela1.79479771
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.78735264
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78071418
58P300_19829295_ChIP-Seq_ESCs_Human1.77859897
59VDR_22108803_ChIP-Seq_LS180_Human1.74231244
60IGF1R_20145208_ChIP-Seq_DFB_Human1.67239390
61* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66694554
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.66146072
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65979363
64CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64715615
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58767099
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58196427
67* REST_18959480_ChIP-ChIP_MESCs_Mouse1.55005724
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53004517
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.48651171
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47816726
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.47786370
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46572779
73MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43583607
74* NANOG_16153702_ChIP-ChIP_HESCs_Human1.43461630
75RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41046630
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38888809
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38490419
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38241944
79IRF1_19129219_ChIP-ChIP_H3396_Human1.36459599
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34786985
81* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34057336
82* TP53_20018659_ChIP-ChIP_R1E_Mouse1.34051510
83CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32972924
84PIAS1_25552417_ChIP-Seq_VCAP_Human1.32232927
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31924122
86VDR_23849224_ChIP-Seq_CD4+_Human1.31123891
87DROSHA_22980978_ChIP-Seq_HELA_Human1.30469129
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27632772
89* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26566924
90* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25145141
91RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24672594
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22525268
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22525268
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22375365
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.21377003
96LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21169532
97FOXP3_21729870_ChIP-Seq_TREG_Human1.21127615
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19850385
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18889560
100E2F1_21310950_ChIP-Seq_MCF-7_Human1.17545614
101SMAD4_21799915_ChIP-Seq_A2780_Human1.17247158
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.16313259
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15375691
104* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.13528036
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09725725
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09418159
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08950445
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08309055
109* AR_25329375_ChIP-Seq_VCAP_Human1.07500458
110* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06371771
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.05863306
112NOTCH1_21737748_ChIP-Seq_TLL_Human1.05067750
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04871954
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04686173
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04298796
116ER_23166858_ChIP-Seq_MCF-7_Human1.04265376
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02983725
118* SOX2_16153702_ChIP-ChIP_HESCs_Human1.02727772
119ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01416061
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.01367482
121POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01275364
122* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00363806
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00304859
124TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98909373
125* AR_19668381_ChIP-Seq_PC3_Human0.98578324
126STAT3_23295773_ChIP-Seq_U87_Human0.98511154
127EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98474429
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.97563746
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.96970816
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96941576
131RUNX2_22187159_ChIP-Seq_PCA_Human0.96567107
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96129853
133P53_22387025_ChIP-Seq_ESCs_Mouse0.95534247
134* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95483525
135JUN_21703547_ChIP-Seq_K562_Human0.95036816
136KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95025970
137KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95025970
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95025970
139* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94933614
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94736038
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94473346
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93352038
143YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91799646
144E2F1_18555785_Chip-Seq_ESCs_Mouse0.91729406
145NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91017172
146GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90800222
147* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.90550197
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88822013
149HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88647142
150* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88401938
151ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88212160
152SUZ12_18555785_Chip-Seq_ESCs_Mouse0.88070574
153NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87949318
154* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87485814
155EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87438132
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86968533
157* ARNT_22903824_ChIP-Seq_MCF-7_Human0.86716693
158AHR_22903824_ChIP-Seq_MCF-7_Human0.86644963
159* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86550676
160SRF_21415370_ChIP-Seq_HL-1_Mouse0.86103405
161* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84307723
162CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83404050
163TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81476943
164POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.81388717
165* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.81063188

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.36253900
2MP0005423_abnormal_somatic_nervous5.16497953
3MP0009379_abnormal_foot_pigmentation4.80152605
4MP0005645_abnormal_hypothalamus_physiol4.64019157
5MP0008995_early_reproductive_senescence3.98530229
6MP0006276_abnormal_autonomic_nervous3.89112451
7MP0010030_abnormal_orbit_morphology3.37609160
8MP0003121_genomic_imprinting3.01658674
9MP0003283_abnormal_digestive_organ2.83843003
10MP0000778_abnormal_nervous_system2.79041871
11MP0003136_yellow_coat_color2.70858630
12MP0004270_analgesia2.58928031
13MP0002638_abnormal_pupillary_reflex2.46636519
14MP0006292_abnormal_olfactory_placode2.40261128
15MP0002822_catalepsy2.37468114
16MP0001984_abnormal_olfaction2.34789077
17MP0003880_abnormal_central_pattern2.32325469
18MP0001293_anophthalmia2.31902779
19MP0000566_synostosis2.24678917
20MP0009053_abnormal_anal_canal2.17782113
21MP0004859_abnormal_synaptic_plasticity2.10118766
22MP0002102_abnormal_ear_morphology2.06679340
23MP0003890_abnormal_embryonic-extraembry1.91788480
24MP0003635_abnormal_synaptic_transmissio1.91603395
25MP0001346_abnormal_lacrimal_gland1.88627665
26MP0001502_abnormal_circadian_rhythm1.86376760
27MP0005409_darkened_coat_color1.84393633
28MP0001529_abnormal_vocalization1.83900779
29* MP0002063_abnormal_learning/memory/cond1.83453587
30MP0003693_abnormal_embryo_hatching1.82823559
31MP0010386_abnormal_urinary_bladder1.79172607
32MP0004133_heterotaxia1.73965131
33MP0002697_abnormal_eye_size1.72949892
34MP0002572_abnormal_emotion/affect_behav1.72854568
35MP0001286_abnormal_eye_development1.65049046
36MP0000631_abnormal_neuroendocrine_gland1.64528126
37* MP0002557_abnormal_social/conspecific_i1.64447656
38MP0002277_abnormal_respiratory_mucosa1.63561022
39MP0010094_abnormal_chromosome_stability1.56184141
40MP0000049_abnormal_middle_ear1.53915245
41MP0008789_abnormal_olfactory_epithelium1.53431683
42MP0002184_abnormal_innervation1.52516299
43MP0001440_abnormal_grooming_behavior1.51591071
44MP0002249_abnormal_larynx_morphology1.51236849
45MP0003011_delayed_dark_adaptation1.51166708
46MP0004742_abnormal_vestibular_system1.49947738
47MP0005646_abnormal_pituitary_gland1.48108342
48MP0002734_abnormal_mechanical_nocicepti1.46570381
49MP0000537_abnormal_urethra_morphology1.46070389
50MP0001486_abnormal_startle_reflex1.41074787
51MP0000538_abnormal_urinary_bladder1.38271086
52MP0002938_white_spotting1.34185337
53MP0002272_abnormal_nervous_system1.34056185
54MP0001968_abnormal_touch/_nociception1.33464963
55MP0008058_abnormal_DNA_repair1.33427989
56MP0002653_abnormal_ependyma_morphology1.33378280
57MP0008932_abnormal_embryonic_tissue1.29617082
58MP0009745_abnormal_behavioral_response1.29223047
59MP0000026_abnormal_inner_ear1.28641082
60MP0005670_abnormal_white_adipose1.28470309
61MP0004885_abnormal_endolymph1.28102540
62MP0002160_abnormal_reproductive_system1.26673839
63MP0004858_abnormal_nervous_system1.23535201
64MP0000516_abnormal_urinary_system1.20441843
65MP0005367_renal/urinary_system_phenotyp1.20441843
66MP0003315_abnormal_perineum_morphology1.20124829
67MP0000955_abnormal_spinal_cord1.18803039
68MP0006072_abnormal_retinal_apoptosis1.18692332
69MP0002282_abnormal_trachea_morphology1.18654293
70MP0003942_abnormal_urinary_system1.18485035
71MP0002751_abnormal_autonomic_nervous1.16912576
72MP0002735_abnormal_chemical_nociception1.16806226
73MP0002733_abnormal_thermal_nociception1.15879358
74MP0005171_absent_coat_pigmentation1.15577180
75MP0003385_abnormal_body_wall1.14081415
76MP0004957_abnormal_blastocyst_morpholog1.14071273
77MP0003567_abnormal_fetal_cardiomyocyte1.14022391
78MP0003137_abnormal_impulse_conducting1.13887557
79MP0002064_seizures1.13313017
80MP0000462_abnormal_digestive_system1.10713045
81MP0002736_abnormal_nociception_after1.10168859
82MP0000569_abnormal_digit_pigmentation1.07439602
83MP0005084_abnormal_gallbladder_morpholo1.07381204
84MP0005391_vision/eye_phenotype1.07347058
85MP0002092_abnormal_eye_morphology1.07271010
86MP0002111_abnormal_tail_morphology1.06643782
87* MP0002152_abnormal_brain_morphology1.04069472
88MP0001963_abnormal_hearing_physiology1.01845007
89MP0002882_abnormal_neuron_morphology1.01801258
90MP0003077_abnormal_cell_cycle1.00959626
91* MP0002067_abnormal_sensory_capabilities1.00579036
92MP0001299_abnormal_eye_distance/0.99935374
93MP0003111_abnormal_nucleus_morphology0.98667572
94MP0002234_abnormal_pharynx_morphology0.97817450
95MP0005195_abnormal_posterior_eye0.97020101
96MP0004142_abnormal_muscle_tone0.96544218
97* MP0003861_abnormal_nervous_system0.94530254
98MP0003938_abnormal_ear_development0.92723239
99MP0002752_abnormal_somatic_nervous0.91111888
100MP0002928_abnormal_bile_duct0.90575333
101MP0000428_abnormal_craniofacial_morphol0.90037049
102MP0003786_premature_aging0.86784892
103MP0003718_maternal_effect0.86358771
104MP0002089_abnormal_postnatal_growth/wei0.86090847
105MP0001501_abnormal_sleep_pattern0.85936142
106MP0001970_abnormal_pain_threshold0.85834437
107MP0005253_abnormal_eye_physiology0.84308179
108* MP0002085_abnormal_embryonic_tissue0.83907697
109MP0002210_abnormal_sex_determination0.83839404
110MP0009046_muscle_twitch0.83480756
111MP0002095_abnormal_skin_pigmentation0.79960831
112MP0003119_abnormal_digestive_system0.78682517
113MP0001145_abnormal_male_reproductive0.78252743
114MP0002837_dystrophic_cardiac_calcinosis0.77278208
115MP0009250_abnormal_appendicular_skeleto0.75542002
116MP0000534_abnormal_ureter_morphology0.73735836
117MP0004145_abnormal_muscle_electrophysio0.73457575
118MP0003634_abnormal_glial_cell0.72964318
119MP0008057_abnormal_DNA_replication0.72951844
120MP0009697_abnormal_copulation0.72408915
121* MP0002066_abnormal_motor_capabilities/c0.72149783
122MP0003935_abnormal_craniofacial_develop0.71872485
123MP0003755_abnormal_palate_morphology0.71677309
124MP0005174_abnormal_tail_pigmentation0.71153367
125* MP0002084_abnormal_developmental_patter0.70683001
126MP0001905_abnormal_dopamine_level0.70604489
127MP0004134_abnormal_chest_morphology0.70257139
128MP0000762_abnormal_tongue_morphology0.70157461
129MP0003937_abnormal_limbs/digits/tail_de0.69713313
130MP0001324_abnormal_eye_pigmentation0.69182128
131MP0001485_abnormal_pinna_reflex0.68534985
132MP0000647_abnormal_sebaceous_gland0.68489556
133MP0005394_taste/olfaction_phenotype0.67828865
134MP0005499_abnormal_olfactory_system0.67828865
135MP0000653_abnormal_sex_gland0.67773045
136MP0005451_abnormal_body_composition0.66094897
137MP0002116_abnormal_craniofacial_bone0.65802240
138MP0002109_abnormal_limb_morphology0.64552261
139MP0001929_abnormal_gametogenesis0.64252923
140MP0004811_abnormal_neuron_physiology0.63496956
141* MP0002081_perinatal_lethality0.61762844
142MP0005377_hearing/vestibular/ear_phenot0.61084131
143MP0003878_abnormal_ear_physiology0.61084131
144MP0004924_abnormal_behavior0.59842183
145MP0005386_behavior/neurological_phenoty0.59842183
146MP0002932_abnormal_joint_morphology0.58193348
147MP0002233_abnormal_nose_morphology0.57344632

Predicted human phenotypes

RankGene SetZ-score
1Polyphagia (HP:0002591)7.98913867
2Failure to thrive in infancy (HP:0001531)6.91015407
3Reticulocytopenia (HP:0001896)5.82342769
4Hemiparesis (HP:0001269)5.28385935
5Sleep apnea (HP:0010535)4.77318159
6Abnormal eating behavior (HP:0100738)4.73209660
7Abnormal number of erythroid precursors (HP:0012131)4.60892709
8Abnormality of cells of the erythroid lineage (HP:0012130)4.53004479
9Abnormality of binocular vision (HP:0011514)4.13363063
10Diplopia (HP:0000651)4.13363063
11Abnormal hair whorl (HP:0010721)4.10858894
12Abnormality of the labia minora (HP:0012880)3.94342924
13Growth hormone deficiency (HP:0000824)3.86166595
14Esotropia (HP:0000565)3.73889190
15Oligodactyly (hands) (HP:0001180)3.70647318
16Macrocytic anemia (HP:0001972)3.40985871
17Hemiplegia (HP:0002301)3.36530533
18Rectovaginal fistula (HP:0000143)3.32373062
19Rectal fistula (HP:0100590)3.32373062
20Thyroid-stimulating hormone excess (HP:0002925)3.29725639
21Oligodactyly (HP:0012165)3.29080361
22Stenosis of the external auditory canal (HP:0000402)3.15979953
23Congenital, generalized hypertrichosis (HP:0004540)3.14938419
24Ectopic kidney (HP:0000086)3.14602820
25Anterior segment dysgenesis (HP:0007700)3.00415630
26Focal motor seizures (HP:0011153)2.97553728
27Absent thumb (HP:0009777)2.95237782
28Bilateral microphthalmos (HP:0007633)2.93066033
29Triphalangeal thumb (HP:0001199)2.92303827
30Acute necrotizing encephalopathy (HP:0006965)2.90561766
31Humeroradial synostosis (HP:0003041)2.87313055
32Synostosis involving the elbow (HP:0003938)2.87313055
33Exotropia (HP:0000577)2.85054735
34Abnormality of the axillary hair (HP:0100134)2.81641760
35Abnormality of secondary sexual hair (HP:0009888)2.81641760
36Intestinal fistula (HP:0100819)2.80351853
37Narrow nasal bridge (HP:0000446)2.79375551
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.78579866
39Pancreatic cysts (HP:0001737)2.76185306
40True hermaphroditism (HP:0010459)2.70188036
41Pancreatic fibrosis (HP:0100732)2.69619943
42Broad-based gait (HP:0002136)2.69348291
43Esophageal atresia (HP:0002032)2.69056729
44Vaginal fistula (HP:0004320)2.67978033
45Duplication of thumb phalanx (HP:0009942)2.67159045
46Short phalanx of the thumb (HP:0009660)2.67031957
47Pallor (HP:0000980)2.65870678
48Duplicated collecting system (HP:0000081)2.65753394
49Pendular nystagmus (HP:0012043)2.61296605
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.58648398
51Cortical dysplasia (HP:0002539)2.58483380
52Colon cancer (HP:0003003)2.58093689
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.56003992
54Abnormality of the renal collecting system (HP:0004742)2.54321873
55Carpal bone hypoplasia (HP:0001498)2.52968861
56Abnormal mitochondria in muscle tissue (HP:0008316)2.51614401
57Generalized tonic-clonic seizures (HP:0002069)2.48311568
58Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.48026385
59Partial duplication of thumb phalanx (HP:0009944)2.47410972
60Drooling (HP:0002307)2.47315687
61Excessive salivation (HP:0003781)2.47315687
62Oligomenorrhea (HP:0000876)2.46852296
63Mitochondrial inheritance (HP:0001427)2.46754007
64Specific learning disability (HP:0001328)2.43522682
65Sclerocornea (HP:0000647)2.41519245
66Chromsome breakage (HP:0040012)2.40441057
67Meckel diverticulum (HP:0002245)2.38882785
68Partial duplication of the phalanx of hand (HP:0009999)2.38683840
69Acute encephalopathy (HP:0006846)2.38602622
70Abnormality of the parietal bone (HP:0002696)2.37799298
71Septo-optic dysplasia (HP:0100842)2.36955190
72Small hand (HP:0200055)2.35378929
73Fibular aplasia (HP:0002990)2.34696681
74Epileptic encephalopathy (HP:0200134)2.32968732
75Hyperglycinemia (HP:0002154)2.30577215
76Rib fusion (HP:0000902)2.29004467
77Nephronophthisis (HP:0000090)2.27864587
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.27093820
79Short 1st metacarpal (HP:0010034)2.27093820
80Concave nail (HP:0001598)2.26914204
81Decreased muscle mass (HP:0003199)2.25987027
82Preaxial foot polydactyly (HP:0001841)2.25013406
83Horseshoe kidney (HP:0000085)2.24897218
84Progressive macrocephaly (HP:0004481)2.24781550
85Absent radius (HP:0003974)2.23647737
86Abnormality of the ileum (HP:0001549)2.23423483
87Gastrointestinal atresia (HP:0002589)2.23273744
88Protruding tongue (HP:0010808)2.22997069
89Hypoventilation (HP:0002791)2.22784526
90Short thumb (HP:0009778)2.22065229
91Molar tooth sign on MRI (HP:0002419)2.21804702
92Abnormality of midbrain morphology (HP:0002418)2.21804702
93Abnormality of the 4th metacarpal (HP:0010012)2.20406464
94Short hallux (HP:0010109)2.19981456
95Hypoplasia of the pons (HP:0012110)2.19893110
96Vertebral fusion (HP:0002948)2.16599069
97Abnormality of the septum pellucidum (HP:0007375)2.16006636
98Limb dystonia (HP:0002451)2.15928219
99Increased hepatocellular lipid droplets (HP:0006565)2.14568951
100Midline defect of the nose (HP:0004122)2.13958219
101Iris hypopigmentation (HP:0007730)2.13539049
102Optic nerve coloboma (HP:0000588)2.13146100
103Anal stenosis (HP:0002025)2.11919019
104Hepatic necrosis (HP:0002605)2.11687508
105Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11429009
1063-Methylglutaconic aciduria (HP:0003535)2.10615201
107Maternal diabetes (HP:0009800)2.10064527
108Aplasia/Hypoplasia of the hallux (HP:0008362)2.06951382
109Anophthalmia (HP:0000528)2.06802763
110Hemivertebrae (HP:0002937)2.06309387
111Hepatocellular necrosis (HP:0001404)2.06204978
112Abnormality of the pons (HP:0007361)2.06204396
113Labial hypoplasia (HP:0000066)2.05790065
114Narrow forehead (HP:0000341)2.03458607
115Aqueductal stenosis (HP:0002410)2.02979950
116Confusion (HP:0001289)2.02199003
117Inability to walk (HP:0002540)2.02030160
118Supranuclear gaze palsy (HP:0000605)2.02014039
119Aplasia involving bones of the extremities (HP:0009825)2.01938989
120Aplasia involving bones of the upper limbs (HP:0009823)2.01938989
121Aplasia of the phalanges of the hand (HP:0009802)2.01938989
122Birth length less than 3rd percentile (HP:0003561)1.99617661
123Medial flaring of the eyebrow (HP:0010747)1.97659195
124Lipid accumulation in hepatocytes (HP:0006561)1.97626302
125Abnormality of the 1st metacarpal (HP:0010009)1.97538507
126Morphological abnormality of the inner ear (HP:0011390)1.96969837
127Coronal craniosynostosis (HP:0004440)1.95927939
128Increased CSF lactate (HP:0002490)1.95290586
129Ankle clonus (HP:0011448)1.93681058
130Abnormality of the carotid arteries (HP:0005344)1.92555624
131Anencephaly (HP:0002323)1.92532589
132Progressive inability to walk (HP:0002505)1.92182659
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91797320
134Down-sloping shoulders (HP:0200021)1.90547290
135Febrile seizures (HP:0002373)1.88097784
136Neonatal respiratory distress (HP:0002643)1.88067032
137Dynein arm defect of respiratory motile cilia (HP:0012255)1.87763307
138Absent/shortened dynein arms (HP:0200106)1.87763307
139Abnormality of chromosome stability (HP:0003220)1.87504751
140Shoulder girdle muscle weakness (HP:0003547)1.87302738
141Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85882827
142Abnormal ciliary motility (HP:0012262)1.85133188
143Preaxial hand polydactyly (HP:0001177)1.85087600
144Short 4th metacarpal (HP:0010044)1.84282237
145Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84282237
146Abnormality of the renal medulla (HP:0100957)1.83968475
147Agitation (HP:0000713)1.83731851
148Abnormal number of incisors (HP:0011064)1.83161628
149Absent forearm bone (HP:0003953)1.82784430
150Aplasia involving forearm bones (HP:0009822)1.82784430
151Split foot (HP:0001839)1.81106752
152Morphological abnormality of the middle ear (HP:0008609)1.80941595
153Hypoplastic female external genitalia (HP:0012815)1.80327230
154Hypoplastic pelvis (HP:0008839)1.79652481
155Scrotal hypoplasia (HP:0000046)1.78756596
156Abnormal respiratory epithelium morphology (HP:0012253)1.78587631
157Abnormal respiratory motile cilium morphology (HP:0005938)1.78587631
158Hypoplastic left heart (HP:0004383)1.78341807
159Aplasia/hypoplasia of the uterus (HP:0008684)1.78041410
160Neoplasm of the oral cavity (HP:0100649)1.77312070
161Abnormality of cochlea (HP:0000375)1.75922233
162Nasal speech (HP:0001611)1.75749851
163Type II lissencephaly (HP:0007260)1.75463712
164Wide cranial sutures (HP:0010537)1.75250572
165Aplasia/Hypoplasia of the clavicles (HP:0006710)1.75243428
166Symphalangism affecting the phalanges of the hand (HP:0009773)1.74496104
167Absent septum pellucidum (HP:0001331)1.72334137
168Abnormality of DNA repair (HP:0003254)1.71701799
169Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.71374268
170Intestinal atresia (HP:0011100)1.71127767
171Abnormality of salivation (HP:0100755)1.69930165
172Widely patent fontanelles and sutures (HP:0004492)1.69573225
173Obsessive-compulsive behavior (HP:0000722)1.69487317
174Short middle phalanx of the 5th finger (HP:0004220)1.67070642
175Hip dysplasia (HP:0001385)1.67048059
176Slow-growing hair (HP:0002217)1.65642904
177Abnormality of hair growth rate (HP:0011363)1.65642904
178Hypogonadotrophic hypogonadism (HP:0000044)1.64837043
179Optic nerve hypoplasia (HP:0000609)1.63344591
180Neurofibrillary tangles (HP:0002185)1.61570091
181Fair hair (HP:0002286)1.61039869
182Lissencephaly (HP:0001339)1.60457410
183Hypoplasia of the brainstem (HP:0002365)1.60457307
184Aplasia/Hypoplasia of the brainstem (HP:0007362)1.60457307
185Absent speech (HP:0001344)1.59973454
186Open mouth (HP:0000194)1.59811280
187Aplasia cutis congenita (HP:0001057)1.59050099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.98396742
2TNIK5.00098464
3VRK24.84735983
4MKNK24.10105661
5NTRK23.88346609
6CDC73.63963242
7TAF13.63020599
8MKNK13.39375714
9EPHB23.26550129
10VRK13.17647398
11CASK3.07265268
12MARK13.05240640
13SIK32.89486492
14PASK2.75106934
15BCR2.59552252
16MAPK152.59521189
17NME12.48899813
18WEE12.43632918
19STK162.38425417
20MAPK132.13629294
21MAP2K71.91929286
22MAP3K121.86651112
23PLK31.85045647
24DYRK21.82077747
25UHMK11.81356960
26ZAK1.72901210
27MINK11.72865778
28MAP3K101.57611823
29CHEK21.53641313
30GRK11.51321868
31KSR11.50035638
32PNCK1.47359278
33TGFBR11.40837112
34FGFR21.39106523
35PHKG21.35591507
36PHKG11.35591507
37PLK41.35234522
38BRSK21.34396095
39CDK191.30121205
40ERBB41.27845615
41MAP2K41.23283346
42TSSK61.16864182
43TTK1.13697877
44ATR1.12353019
45SRPK11.10269826
46MAP3K41.09838646
47NUAK11.08935201
48EIF2AK21.06815122
49MAP3K91.05272167
50CCNB11.00879583
51MARK20.97592240
52PKN10.95708931
53CAMK1D0.94661479
54NEK20.92209910
55CDK90.89368832
56PLK10.88105037
57CDK180.87800747
58PINK10.83732048
59AKT20.83457006
60STK38L0.83156004
61INSRR0.81796035
62AURKB0.81401258
63CDK80.80862090
64BRD40.80670750
65CDK30.79933411
66BMPR1B0.79250708
67MAPKAPK50.78025557
68PRKCG0.75635841
69CAMK1G0.75599534
70STK40.74778981
71IRAK20.73799484
72CDK150.70423676
73ICK0.70374259
74ERBB20.69952864
75FGFR10.66483126
76NEK10.66231253
77NTRK30.65141335
78CDK11A0.65111796
79LMTK20.63123575
80CLK10.62690361
81ERBB30.62359423
82FES0.62312079
83DYRK1A0.62196057
84ADRBK20.59390822
85CDK50.59270074
86TYRO30.59127702
87BRSK10.58851401
88YES10.57763865
89DYRK30.57753795
90CDK70.57603001
91RPS6KA50.56810358
92CSNK2A10.54769808
93CHEK10.54203233
94FGFR40.54079566
95CDK140.53186730
96ATM0.49870838
97CSNK2A20.46786938
98MAP3K110.46758088
99PIM10.46443205
100PAK30.45245701
101ROCK10.45106155
102STK110.44990416
103CSNK1G30.44387995
104CDK20.43654741
105PRKCE0.43282101
106EEF2K0.41720241
107RPS6KA20.41595734
108ADRBK10.41499891
109PAK60.41226914
110CSNK1A1L0.41157452
111PLK20.41145124
112PRKDC0.40470211
113FYN0.40359388
114CSNK1A10.39763014
115MAPK90.39732146
116SGK20.39319821
117CDC42BPA0.39071973
118MUSK0.38810199
119MAPK120.38101351
120STK240.37219003
121DAPK30.37188353
122CAMK2A0.36567652
123CDK10.36028308
124CAMK10.35963536
125CSNK1G20.35925362
126PBK0.35230221
127CHUK0.35145932
128MAPK40.34740865
129FER0.34052158
130WNK40.33872680
131NLK0.33201833
132TAOK20.32332404
133LATS20.32166353
134CSNK1E0.31949814
135PRKAA10.31886812
136SGK10.30450399
137BUB10.29975815
138SGK4940.29744858
139SGK2230.29744858
140CDK40.29164312
141DYRK1B0.27946481
142IRAK10.27893262
143AURKA0.27774355
144GSK3B0.27473370
145PRKACB0.27435476
146PRKACA0.26508595
147ACVR1B0.26262457
148OXSR10.26153618
149MELK0.25797765
150EPHA40.24486597
151ROCK20.23968560
152PRKCB0.23683930
153TLK10.23550898
154CSNK1G10.22802844
155MAP2K60.22007931
156PRKCA0.21605151
157MAPK70.21570645

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.61679385
2Nicotine addiction_Homo sapiens_hsa050334.49910337
3Parkinsons disease_Homo sapiens_hsa050123.26503209
4Basal cell carcinoma_Homo sapiens_hsa052173.12073622
5Homologous recombination_Homo sapiens_hsa034402.88498438
6DNA replication_Homo sapiens_hsa030302.73759447
7Axon guidance_Homo sapiens_hsa043602.68846817
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.67699972
9Huntingtons disease_Homo sapiens_hsa050162.61254875
10Mismatch repair_Homo sapiens_hsa034302.51046348
11Hedgehog signaling pathway_Homo sapiens_hsa043402.50442866
12GABAergic synapse_Homo sapiens_hsa047272.25246467
13Alzheimers disease_Homo sapiens_hsa050102.21912182
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.14883051
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12622533
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.08600081
17Insulin secretion_Homo sapiens_hsa049112.04279309
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.02630508
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01674906
20Cardiac muscle contraction_Homo sapiens_hsa042601.99277037
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.94555118
22Protein export_Homo sapiens_hsa030601.94212901
23Proteasome_Homo sapiens_hsa030501.94038318
24Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.92241444
25Morphine addiction_Homo sapiens_hsa050321.86941864
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78260269
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.72175133
28Glutamatergic synapse_Homo sapiens_hsa047241.70643707
29Taste transduction_Homo sapiens_hsa047421.63908234
30Nitrogen metabolism_Homo sapiens_hsa009101.60983595
31Wnt signaling pathway_Homo sapiens_hsa043101.59986001
32Nucleotide excision repair_Homo sapiens_hsa034201.55868116
33Salivary secretion_Homo sapiens_hsa049701.55727805
34RNA degradation_Homo sapiens_hsa030181.47648025
35One carbon pool by folate_Homo sapiens_hsa006701.44218458
36Serotonergic synapse_Homo sapiens_hsa047261.40839306
37Gap junction_Homo sapiens_hsa045401.37045363
38Basal transcription factors_Homo sapiens_hsa030221.35803821
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.35591835
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33821176
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32937424
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32917495
43RNA transport_Homo sapiens_hsa030131.32902358
44Non-homologous end-joining_Homo sapiens_hsa034501.32313268
45Hippo signaling pathway_Homo sapiens_hsa043901.32126393
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31355097
47Renin secretion_Homo sapiens_hsa049241.28153380
48Cell cycle_Homo sapiens_hsa041101.26694322
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26602740
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.23951565
51Sulfur relay system_Homo sapiens_hsa041221.23375945
52TGF-beta signaling pathway_Homo sapiens_hsa043501.22898197
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21961394
54Synaptic vesicle cycle_Homo sapiens_hsa047211.19397132
55Fatty acid biosynthesis_Homo sapiens_hsa000611.19210258
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17205530
57Olfactory transduction_Homo sapiens_hsa047401.16863608
58Dilated cardiomyopathy_Homo sapiens_hsa054141.15622259
59Pyrimidine metabolism_Homo sapiens_hsa002401.15155316
60Melanogenesis_Homo sapiens_hsa049161.13864803
61Circadian entrainment_Homo sapiens_hsa047131.11125815
62Selenocompound metabolism_Homo sapiens_hsa004501.06783699
63Circadian rhythm_Homo sapiens_hsa047101.04895252
64Mineral absorption_Homo sapiens_hsa049781.04783747
65Notch signaling pathway_Homo sapiens_hsa043301.02449242
66Fatty acid metabolism_Homo sapiens_hsa012120.99222010
67Ether lipid metabolism_Homo sapiens_hsa005650.98987981
68Gastric acid secretion_Homo sapiens_hsa049710.98077297
69Purine metabolism_Homo sapiens_hsa002300.97506175
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96441814
71Calcium signaling pathway_Homo sapiens_hsa040200.95241128
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94546837
73Steroid biosynthesis_Homo sapiens_hsa001000.94458823
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.93984108
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.93692153
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92264084
77Autoimmune thyroid disease_Homo sapiens_hsa053200.91499196
78Fanconi anemia pathway_Homo sapiens_hsa034600.90963533
79Folate biosynthesis_Homo sapiens_hsa007900.89733341
80Phototransduction_Homo sapiens_hsa047440.83176075
81Butanoate metabolism_Homo sapiens_hsa006500.80554669
82Fatty acid elongation_Homo sapiens_hsa000620.78151168
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76640771
84Dopaminergic synapse_Homo sapiens_hsa047280.75260179
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74842346
86Vitamin digestion and absorption_Homo sapiens_hsa049770.74760320
87Pancreatic secretion_Homo sapiens_hsa049720.74664768
88Bile secretion_Homo sapiens_hsa049760.74401685
89Phagosome_Homo sapiens_hsa041450.72800355
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72577344
91Arginine and proline metabolism_Homo sapiens_hsa003300.72259632
92Renin-angiotensin system_Homo sapiens_hsa046140.70583503
93Oocyte meiosis_Homo sapiens_hsa041140.69708899
94Systemic lupus erythematosus_Homo sapiens_hsa053220.68801999
95Linoleic acid metabolism_Homo sapiens_hsa005910.66633650
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66625130
97Pyruvate metabolism_Homo sapiens_hsa006200.65366772
98Long-term depression_Homo sapiens_hsa047300.62159637
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61960578
100Spliceosome_Homo sapiens_hsa030400.61522305
101cAMP signaling pathway_Homo sapiens_hsa040240.59959960
102Propanoate metabolism_Homo sapiens_hsa006400.59354583
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.58876794
104MAPK signaling pathway_Homo sapiens_hsa040100.57810779
105Metabolic pathways_Homo sapiens_hsa011000.57512674
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.57471167
107Alcoholism_Homo sapiens_hsa050340.56943030
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55746188
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.54888128
110PPAR signaling pathway_Homo sapiens_hsa033200.54744445
111Ras signaling pathway_Homo sapiens_hsa040140.54597791
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54344123
113p53 signaling pathway_Homo sapiens_hsa041150.53625831
114Colorectal cancer_Homo sapiens_hsa052100.53556848
115Viral myocarditis_Homo sapiens_hsa054160.52946048
116Prion diseases_Homo sapiens_hsa050200.52542802
117Melanoma_Homo sapiens_hsa052180.52393310
118Cocaine addiction_Homo sapiens_hsa050300.51076530
119Base excision repair_Homo sapiens_hsa034100.50879704
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50580629
121Cholinergic synapse_Homo sapiens_hsa047250.50493525
122Arachidonic acid metabolism_Homo sapiens_hsa005900.50279492
123Oxidative phosphorylation_Homo sapiens_hsa001900.50123746
124Oxytocin signaling pathway_Homo sapiens_hsa049210.49039793
125Lysine degradation_Homo sapiens_hsa003100.48715079
126Chemical carcinogenesis_Homo sapiens_hsa052040.48376165
127Glutathione metabolism_Homo sapiens_hsa004800.47401680
128Tryptophan metabolism_Homo sapiens_hsa003800.46871764
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46394608
130alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46025588
131beta-Alanine metabolism_Homo sapiens_hsa004100.45990210
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45664129
133ErbB signaling pathway_Homo sapiens_hsa040120.44970203
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43668496
135RNA polymerase_Homo sapiens_hsa030200.43414320
136Dorso-ventral axis formation_Homo sapiens_hsa043200.42252817
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41885002
138Pathways in cancer_Homo sapiens_hsa052000.41849584
139Choline metabolism in cancer_Homo sapiens_hsa052310.41157750
140Fatty acid degradation_Homo sapiens_hsa000710.40344203
141Ovarian steroidogenesis_Homo sapiens_hsa049130.38403189
142mRNA surveillance pathway_Homo sapiens_hsa030150.38125204
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38021170
144Peroxisome_Homo sapiens_hsa041460.36439823
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36363021
146Fat digestion and absorption_Homo sapiens_hsa049750.26476241
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26445887
148Histidine metabolism_Homo sapiens_hsa003400.25670983
149Collecting duct acid secretion_Homo sapiens_hsa049660.24926262
150N-Glycan biosynthesis_Homo sapiens_hsa005100.24771257
151Retinol metabolism_Homo sapiens_hsa008300.24584079
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23140782
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22254934
154Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17602195
155Tyrosine metabolism_Homo sapiens_hsa003500.17510106

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